Validity and Limitations of Rat Mesoappendix Bioassay Studies
作者:
Benjamin Zweifach,
Delilah Metz,
期刊:
Circulation Research
(OVID Available online 1955)
卷期:
Volume 3,
issue 2
页码: 121-132
ISSN:0009-7330
年代: 1955
出版商: OVID
数据来源: OVID
摘要:
Bioassay data obtained by the rat mesoappendix method lend themselves poorly to statistical representation. Sufficient reproducibility for quantitative estimation of the titer of vasoactive materials was achieved only with crystalline substances or purified biological extracts. Neither the duration of the displacement of epinephrine reactivity nor the magnitude of the shift in effective constrictor doses of epinephrine provided a satisfactory measure of vasoactivity in blood specimens. A prozone phenomenon, with agents such as Pitressin, histamine and ferritin was encountered with potentiating effects being elicited in high dose ranges and inhibitory effects in low dose ranges.
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