A Congenital Heart Defect inDrosophilaCaused by an Action-Potential Mutation
作者:
DowseHarold,
RingoJohn,
PowerJohn,
KinneyKurt,
WhiteLori,
期刊:
Journal of Neurogenetics
(Taylor Available online 1995)
卷期:
Volume 10,
issue 3
页码: 153-168
ISSN:0167-7063
年代: 1995
DOI:10.3109/01677069509083461
出版商: Taylor&Francis
关键词: Cardiac arrhythmia;heartbeat;spectral analysis no action potential mutant;period mutant
数据来源: Taylor
摘要:
The mutationno action potentialtemperature itive(napts) induces arrhythmia in the heartbeat ofDrosophila melanogasterlarvae at temperatures above 20°C; heartbeat becomes normally rhythmic again after a shift back to 20°C. For this phenotype,naptsis almost completely recessive to the wild type.naptsalso reduces the temperature-sensitivity of heart rate over a wide range of temperatures, for this phenotype,napts, is dominant over the wild type,naptscauses reversible paralysis in adults by epistatic effects on the expression ofparalytic, a gene encoding a voltage-dependent sodium channel. However, theparamutation, which induces paralysis in adults at 29°C, has no effect on larval heartbeat at temperatures between 20°and 37.5°C. Theperiodgene,contraearlier reports, has no effect on heartbeat.
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