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A Congenital Heart Defect inDrosophilaCaused by an Action-Potential Mutation

 

作者: DowseHarold,   RingoJohn,   PowerJohn,   KinneyKurt,   WhiteLori,  

 

期刊: Journal of Neurogenetics  (Taylor Available online 1995)
卷期: Volume 10, issue 3  

页码: 153-168

 

ISSN:0167-7063

 

年代: 1995

 

DOI:10.3109/01677069509083461

 

出版商: Taylor&Francis

 

关键词: Cardiac arrhythmia;heartbeat;spectral analysis no action potential mutant;period mutant

 

数据来源: Taylor

 

摘要:

The mutationno action potentialtemperature itive(napts) induces arrhythmia in the heartbeat ofDrosophila melanogasterlarvae at temperatures above 20°C; heartbeat becomes normally rhythmic again after a shift back to 20°C. For this phenotype,naptsis almost completely recessive to the wild type.naptsalso reduces the temperature-sensitivity of heart rate over a wide range of temperatures, for this phenotype,napts, is dominant over the wild type,naptscauses reversible paralysis in adults by epistatic effects on the expression ofparalytic, a gene encoding a voltage-dependent sodium channel. However, theparamutation, which induces paralysis in adults at 29°C, has no effect on larval heartbeat at temperatures between 20°and 37.5°C. Theperiodgene,contraearlier reports, has no effect on heartbeat.

 

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