Successful Eradicating Treatment of Helicobacter Pylori in Patients with Chronic Gastritis: Gastric Les of Cytokines, Epidermal Growth Factor and Polyamines Before and After Therapy
作者:
MessaC.,
LeoA. Di,
GrecoB.,
CaradonnaL.,
AmatiL.,
LinsalataM.,
GiorgioI.,
JirilloE.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1996)
卷期:
Volume 18,
issue 1
页码: 1-13
ISSN:0892-3973
年代: 1996
DOI:10.3109/08923979609007106
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractIn 10 patients with Helicobacter pylori (HP) positive chronic gastritis, gastric mucosal content of lnterleukin (IL)-1βIL-8, Transforming Growth Factor (TGF)-β1, Epidermal Growth Factor (EGF) and Polyamines (putrescine, spermine and spermidine) was evaluated before and after eradicating treatment. Histologically, in all patients eradication of HP was accompanied by a marked reduction of the inflammmatory infiltrate. At the same time, at the end of the therapeutical regimen, elevated levels of IL-1β, IL-8, TGF-β1, putrescine and spermidine/spermine ratio significantly dropped, while EGF mucosal content, significantly increased.Results are discussed in terms of the reciprocal role of inflammatory cytokines, growth factors and polyamines in the evolution of the HP-associated chronic gastritis.
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