The Synergistic Effect of Trauma and Infection on Interleukin-1 but Not Tumor Necrosis Factor Liberation during Posttraumatic Gram-Negative Septicemia
作者:
O. Røkke,
A. Revhaug,
R. Seljelid,
O. Rekvig,
期刊:
European Surgical Research
(Karger Available online 1993)
卷期:
Volume 25,
issue 1
页码: 1-10
ISSN:0014-312X
年代: 1993
DOI:10.1159/000129251
出版商: S. Karger AG
关键词: Trauma;Septicemia;Interleukin-1;Tumor necrosis factor;Endotoxin
数据来源: Karger
摘要:
The release profiles of interleukin 1 (Il-1) and tumor necrosis factor (TNF) were studied during experimental Escherichia coli4 h) the Il-1 response. During peritonitis, a delayed (30 min) but otherwise similar Il-1-response was observed. TNF levels rose rapidly (+30 min) in all animals, and remained high throughout the experimental period (6 h). The trauma did not influence the TNF response. We conclude that a synergism exists between trauma and infection with regard to the magnitude of the Il-1 respon
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