Macrophage proliferation in atherosclerosis
作者:
Masakazu Sakai,
Shozo Kobori,
Akira Miyazaki,
Seikoh Horiuchi,
期刊:
Current Opinion in Lipidology
(OVID Available online 2000)
卷期:
Volume 11,
issue 5
页码: 503-509
ISSN:0957-9672
年代: 2000
出版商: OVID
数据来源: OVID
摘要:
Oxidized LDL can induce an increase in intracellular calcium concentration and the activation of protein kinase C in mouse peritoneal macrophages. The activation of protein kinase C leads to the release into the culture medium of granulocyte-macrophage colony-stimulating factor, which plays a priming role in oxidized LDL-induced macrophage proliferation. The expression of granulocyte-macrophage colony-stimulating factor in macrophages by oxidized LDL is positively regulated in the 5′-flanking region of granulocyte-macrophage colony-stimulating factor gene from sequence −169 to −160, but negatively regulated from −91 to −82. Granulocyte-macrophage colony-stimulating factor released by oxidized LDL from macrophages induces proliferation in autocrine or paracrine fashion via the activation of phosphatidylinositol 3-kinase. The capacity of oxidized LDL to induce macrophage proliferationin vitromay be involved in the enhanced progression of atherosclerosisin vivo.
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