Autoradiographic Investigation of Effects of High-Dose Colchicine on Dentinogenesis in Rat Incisors
作者:
T.O. Nogueira,
T.M.T. Zorn,
T. Stene,
H.S. Koppang,
期刊:
Cells Tissues Organs
(Karger Available online 1988)
卷期:
Volume 133,
issue 1
页码: 45-49
ISSN:1422-6405
年代: 1988
DOI:10.1159/000146613
出版商: S. Karger AG
关键词: Dentinogenesis;Antimicrotubular agents;Colchicine
数据来源: Karger
摘要:
Twelve female Wistar rats received 1.5 mg/kg of colchicine (CLC) intravenously. Control animals were similarly injected with isotonic saline solution. The animals were killed 5 h, 24 h, 3 days and 7 days after injection. Ninety minutes prior to sacrifice, all animals received an intraperitoneal injection of 3H-proline. Autoradiograms of maxillary incisors showed that CLC increased the retention of the labeled precursor in the odontoblasts. It was also shown that the odontoblasts in the different sectors of the rat incisor present different sensitivities to the CLC action.
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