This article reviews a number of advances in small intestinal motility that are of particular interest to clinicians. New methods involve studying relationships between contractions and transit and between luminal distension, tone, and sensation. Interactions between brain and gut are helping us understand how hypnosis helps alleviate symptoms, and treatment of transit failure with pacing or transplantation seems much more feasible than ever before. There is now evidence that duodenal ulcer disease is due to a motility disorder after all, and there are reports of prokinetic drugs that may eventually be used to treat it.