首页   按字顺浏览 期刊浏览 卷期浏览 Effects of an Organosilicon Compound on the Tubular Apparatus of Rat Kidney
Effects of an Organosilicon Compound on the Tubular Apparatus of Rat Kidney

 

作者: Syed G. Haider,   Dorothea Rolauffs,   Hans Günter Goslar,   Oskar Stuhl,   Leonhard Birkofer,  

 

期刊: Cells Tissues Organs  (Karger Available online 1988)
卷期: Volume 131, issue 1  

页码: 9-12

 

ISSN:1422-6405

 

年代: 1988

 

DOI:10.1159/000146478

 

出版商: S. Karger AG

 

关键词: Organosilicone;Silicon organic compound;Kidney;Rat;Histology;Enzyme histochemistry

 

数据来源: Karger

 

摘要:

Male adult Wistar rats were treated for 8 weeks with an organosilicone [2,2-dimethyl-4-(chloromethyl)-1,3-dioxa-2-silacyclopentane] employing two different dosages (25 and 50 mg/kg body weight i.p. daily) and the changes in the tubular apparatus of the kidney were investigated employing histological and enzyme-histochemical methods. The effects, more pronounced at the higher dosage, were the following: The brush borders of the proximal tubules were stuck together and disintegrated; only few epithelial cells remained intact showing a decreased activity of nonspecific esterases and the increase of β-hydroxybutyric acid dehydrogenase. The nuclei of most of the epithelial cells in the distal tubules were dislocated towards the enlarged lumen and the cytoplasma showed a decrease of nonspecific esterases and an increase of β-hydroxybutyric acid dehydrogenase. The collagen fibers in the walls of the collecting tubules were dislocated and disintegrated with a discontinuous border of Mg2+-ATPase; the nuclei of the epithelial cells were pyknotic, the cytoplasma showed an increase of β-hydroxybutyric acid dehydrogenase. The induced changes were partially reversible after a recovery period of 8 wee

 

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