VARIANTS OF Mta, THE MOUSE MATERNALLY TRANSMITTED ANTIGEN, DETERMINED BY THREE ALLELES OF THE EXTRACHROMOSOMAL GENEMtf
作者:
K. Fischer Lindahl,
B. Hausmann,
J.‐L. Guénet,
期刊:
International Journal of Immunogenetics
(WILEY Available online 1990)
卷期:
Volume 17,
issue 1‐2
页码: 29-41
ISSN:1744-3121
年代: 1990
DOI:10.1111/j.1744-313X.1990.tb00857.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SUMMARYTwo new forms of Mta, the maternally transmitted antigen of the mouse, were defined by cytotoxic T lymphocytes. One is found in laboratory mice carrying the β allele of the maternally transmitted factor,Mtf, which were previously thought to be Mta‐negative. The other is associated with a new allele,Mtfγ, and is found in wild mice from Toulouse. Like the common form of Mta, determined by the extrachromosomalMrfα, the new forms are also dependent on the α allele ofHmt, a chromosomal gene linked toH‐2. and are associated with β2‐microglobulin. Killers could be raised in all six combinations of a, β, and γ mice, showing that each form ofMtfdetermines a distinct (set of) epitope(s). We propose that the product of theHmtgene, a class I MHC antigen, presents a peptide derived from a mitochondrial gene product on the cell surface and thereby creates the target
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