SummaryNinety‐three cases of intoxication polyneuropathy occured among household workers exposed to excess concentrations of the n‐hexane vapor over several months or more.1The chief manifestation was polyneuropathy of glove‐and‐stocking type. According to the mode of involvement, they were classified into three groups: sensory polyneuropathy 53 cases, sensorimotor polyneuropathy 32 cases and sensorimotor polyneuropathy with amyotrophy 8 cases. Slight optic nerve involvements were observed in 8 cases. No symptoms or signs indicating lesions of the central nervous system and of spinal cord were discovered. In severely affected cases the symptoms progressed for about 2 months even after detachment from noxious environment.2No constant significant abnormalities were revealed in the laboratory examinations including urinalysis, complete blood counts, liver function tests, S T S and cerebrospinal fluid studies.3Biopsies of the peripheral nerve disclosed destruction of the myeline sheath with relatively well preserved axon. Muscle biopsies revealed that muscle tissue was largely replaced by fatty tissue and showed the features of neurogenic atrophy. Electromyography and conduction velocity of the peripheral nerve coincide with denervation and reinnervation processes of the nerve.4Characteristic features of this disease are discussed in comparison with other intoxication polyneuro