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Inhibition of the Membrane Localization of p21rasProteins by Lovastatin in Tumor Cells Possessing a Mutated N-rasGene

 

作者: Rainer Girgert,   Patrizia Marini,   Andrea Janessa,   Gemot Bruchelt,   Jorn Treuner,   Paul Schweizer,  

 

期刊: Oncology  （Karger Available online 1994）
卷期: Volume 51, issue 4  

页码: 320-322

 

ISSN:0030-2414

 

年代: 1994

 

DOI:10.1159/000227357

 

出版商: S. Karger AG

 

关键词: Acute myeloid leukemia;Neuroblastoma;N-ras;Farnesylation;Lovastatin

 

数据来源: Karger

 

摘要:

Mutated ras genes are found in a variety of human tumors. For biological activity the gene product p21 ras needs to be bound to the cell membrane by a farnesyl residue. Treatment of tumor cells with lovastatin reduces the availability of farnesyl pyrophosphate for the modification of the ras proteins. The membrane localization of p21 ras has been reduced by 30-36% after the tumor cells have grown in the presence of 10 μM lovastatin for 7 days. The extent of the inhibition depends on the growth kinetics of the cell lines.

 

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