Propranolol Versus Diazepam in the Management of the Alcohol Withdrawal Syndrome: Double-Blind Controlled Trial
作者:
WornerT. M.,
期刊:
The American Journal of Drug and Alcohol Abuse
(Taylor Available online 1994)
卷期:
Volume 20,
issue 1
页码: 115-124
ISSN:0095-2990
年代: 1994
DOI:10.3109/00952999409084061
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Thirty-seven male alcoholics admitted electively for detoxification were randomized to treatment with either diazepam or propranolol. Subjects were comparable both in age and in duration and quantity of alcohol consumed. Admission laboratory parameters did not distinguish between the groups. Eleven subjects required no medication to control withdrawal signs/symptoms. Both groups showed improvement in blood pressure, pulse, and withdrawal tremor. None of the subjects randomized to diazepam manifested withdrawal seizures or hallucinations. By contrast, one subject in the propranolol group had a single withdrawal seizure. Another subject manifested increasing withdrawal that required parenteral paraldehyde treatment. Thus, this study confirms that a significant number of subjects admitted electively for alcohol withdrawal can be managed without medication. Minor tranquilizers still remain the“gold standard”for management of the withdrawal syndrome.
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