This review covers significant work on drugs working on the intestine for the year up to June 1990. Developments in bile acid sequestrants and related drugs are discussed. Some novel properties of β-hydroxy-β-methylglutaryl coenzyme A reductase inhibitors are considered. Finally, the role of acyl coenzyme A: cholesterol acyltransferase, cholesteryl ester hydrolase and compounds affecting these enzymes in intestinal cholesterol absorption are assessed.