Lack of effect of diphenylhydantoin ingestion on vesical transitional epithelium in the rat
作者:
D. F. McDonald,
期刊:
Journal of Surgical Oncology
(WILEY Available online 1969)
卷期:
Volume 1,
issue 1
页码: 77-79
ISSN:0022-4790
年代: 1969
DOI:10.1002/jso.2930010109
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractSeizure‐prone patients may be chronically treated with diphenylhydantoin, a mitogenic agent excreted in the urine. Chronic ingestion of diphenylhydantoin by 64 rats failed to demonstrate vesical epithelial tumor formation under conditions which demonstrate the tumorigenicity of other vesical carcinogens. Vesical neoplasms occurring in patients chronically ingesting diphenylhydantoin are probably co‐inciden
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