The Role of Bile and Bile Acids in Bacterial Translocation in Obstructive Jaundice in Rats
作者:
J.W. Ding,
R. Andersson,
V. Soltesz,
R. Willén,
S. Bengmark,
期刊:
European Surgical Research
(Karger Available online 1993)
卷期:
Volume 25,
issue 1
页码: 11-19
ISSN:0014-312X
年代: 1993
DOI:10.1159/000129252
出版商: S. Karger AG
关键词: Obstructive jaundice;Cholestasis;Septicaemia;Endotoxin;Bile;Bile acid
数据来源: Karger
摘要:
Male Sprague-Dawley rats were randomly divided into five groups in which group 1 received a sham operation (controls), groups 2-5 underwent common bile duct ligation and transection 14 days before the experiments. Two days prior to the studies, animals in groups 1 and 2 received saline orally, while groups 3–5 received an oral administration of either cholic acid, deoxycholic acid or whole bile. Specimens were taken for bacterial culture, and blood was collected for endotoxin assay. The rate of positive bacterial cultures from mesenteric lymph nodes in jaundiced salinetreated animals was significantly higher (p < 0.05) as compared with both controls and the other jaundiced animals treated with either bile or bile acids. Assays were positive for endotoxin in the jaundiced salinetreated group, whereas they were negative in both controls and bile- or bile-acid-treated animals. We conclude that oral administration of cholic acid, deoxycholic acid or whole bile inhibited bacterial translocation and endotoxin absorption in obstructive jaundice in the ra
点击下载:
PDF
(1663KB)
返 回