Chemotherapy of Metastatic Soft Tissue Sarcoma with a Combination of Adriamycin and DTIC or Adriamycin and Ifosfamide
作者:
H.J. Weh,
M. Zügel,
D. Wingberg,
R. Schwarz,
C. Zornig,
M. Dietel,
D.K. Hossfeld,
期刊:
Onkologie
(Karger Available online 1990)
卷期:
Volume 13,
issue 6
页码: 448-452
ISSN:0378-584X
年代: 1990
DOI:10.1159/000216818
出版商: S. Karger GmbH
关键词: Metastatic soft tissue sarcomas;Adriamycin/DTIC;Adriamycin/ ifosfamide
数据来源: Karger
摘要:
Between 1982 and 1986, 38 patients with soft tissue sarcomas were treated with a combination of ADM/DTIC (group A), another 45 (group B) received ADM/IFO between 1986 and 1990. Clinical characteristics were comparable in both groups. Remission rate was 34 % in group A and 43 % in group B. Duration of remission was 10 months and median survival 13 months in both groups. Toxicity, especially myelotoxicity, was severe without marked differences between both groups. We conclude that adriamycin/DTIC and adriamycin/ifosfamide are both active regimens in metastatic soft tissue sarcomas, nevertheless, overall prognosis remains poor.
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