Four Years' Experience with Cyclosporin A in Pediatric Kidney Transplantation1
作者:
P. F. HOYER,
G. OFFNER,
B. S. OEMAR,
J. BRODEHL,
B. RINGE,
R. PICHLMAYR,
期刊:
Acta Pædiatrica
(WILEY Available online 1990)
卷期:
Volume 79,
issue 6‐7
页码: 622-629
ISSN:0803-5253
年代: 1990
DOI:10.1111/j.1651-2227.1990.tb11526.x
出版商: Blackwell Publishing Ltd
关键词: kidney transplantation;children;cyclosporin A;kidney function;hypertension;growth
数据来源: WILEY
摘要:
ABSTRACT.From 1982 to 1987 sixty‐three children were treated with cyclosporin A and low dose prednisolone after kidney transplantation. Patient survival rate at 4 years after transplantation was 98.3 %, survival rate of living related grafts 100 % (n = 10), and survival rate of cadaveric grafts 73 % (n = 53). Adequate cyclosporin blood levels were achieved in all children with a dosage regimen related to body surface area. Major concerns during the observation period were the loss of glomerular filtration rate from 51.8 to 40.5 ml/min/1.73 m2, a hypertension rate of 77.8 %, and hyperuricemia. Cyclosporin A‐side effects were mild. Infections occurred in 11.1 %. Growth retardation in prepu‐bertal children improved by 0.74 standard deviations of normal height, and in pubertal children by 0.51. We conclude that cyclosporin A treatment in children enables excellent long term graft survival rates with improved growth rehabilitation, however, the prevention of the cyclosporin associated nephrotoxicity and hypertension remains the major pr
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