Frequent Overexpression of p53 in Dysgerminoma of the Ovary
作者:
J. Dietl,
H.-P. Horny,
E. Kaiserling,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1994)
卷期:
Volume 37,
issue 2
页码: 141-142
ISSN:0378-7346
年代: 1994
DOI:10.1159/000292543
出版商: S. Karger AG
关键词: Dysgerminoma;p53;Immunohistochemistry
数据来源: Karger
摘要:
The expression of p53 in 7 dysgerminomas of the ovary was investigated immunohistochemically with the monoclonal antibodies DAKO-p53/Do-7 and Dianova-p53/Do-l. All the tumors exhibited overexpression of p53 protein. Immunoreactive tumor cell nuclei amounted to more than 50% in 2 tumors, 10–50% in 2 tumors, and less than 10% in 3 tumors. No relationship was found between tumor stage and the degree of p53 expression. Overexpression of p53 thus appears to be very common in dysgerminoma, as it is in epithelial ovarian cancer.
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