Coronary Artery Plaque Rapidly Induced by Local Electromagnetic Stimulation in the Baboon
作者:
H. Breuer,
J. Fincham,
P. Hinrichsen,
C.J. Uys,
H. Weich,
B. Reichart,
期刊:
European Surgical Research
(Karger Available online 1989)
卷期:
Volume 21,
issue 2
页码: 123-128
ISSN:0014-312X
年代: 1989
DOI:10.1159/000129012
出版商: S. Karger AG
关键词: Coronary artery;Electrical stimulation;Atherosclerotic plaque;Baboon;Stenosis;Diet;western
数据来源: Karger
摘要:
A reliable method has been developed to produce stenosis of the right coronary artery of baboons as a consequence of electrostimulation of the vessel at a chosen position. At that site a pair of electrodes were implanted and activated with a train of 9-volt pulses (length: 10 ms, separation: 100 ms) for 30 min, 5 days/week, up to 6 weeks. 13 animals were included in the experiment, 2 of those served as controls. Pathohistologically the structure of the artificially produced constrictions is similar to atherosclerotic lesions. On average the stenoses occupied 55% of the available lumen; total occlusion and no stenosis were observed in 1 case each.
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