Electrodermal Orienting Response and Central Nervous SystemDopamine and Serotonin Activity in Schizophrenia
作者:
LENNART ÖHLUND,
LEIF LINDSTRÖM,
ARNE ÖHMAN,
期刊:
The Journal of Nervous and Mental Disease
(OVID Available online 1992)
卷期:
Volume 180,
issue 5
页码: 304-313
ISSN:0022-3018
年代: 1992
出版商: OVID
数据来源: OVID
摘要:
The present study was designed to examine the relationship between electrodermal activity and the levels of the dopamine metabolite homovanillic acid (HVA) and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid. Lumbar cerebrospinal fluid from 36 unmedicated and six medicated schizophrenic patients and 23 controls was analyzed by gas chromatograph-mass spectrometer. The schizophrenic patients and a group of 14 normal controls were presented with a series of orienting tones (1000 Hz, 80 db, 2-second duration) while electrodermal activity was monitored. For the patients, this occurred during an acute episode of schizophrenia. The results suggest an inverse relation between electrodermal activity and the CSF-level of HVA. Although the picture is not entirely consistent, electrodermal nonresponders appear to have normal HVA levels, while electrodermal responders have decreased levels compared with normal controls. There is also a relation between electrodermal activity and 5-HIAA, but this association is not as clear-cut as the one between electrodermal activity and HVA.
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