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Virus Inhibitory Effect of Combination of 9-(S)-(2,3-Dihydroxypropyl) Adenine and 6-Azauridine

 

作者: B. Rada,   A. Holý,  

 

期刊: Chemotherapy  （Karger Available online 1980）
卷期: Volume 26, issue 3  

页码: 184-190

 

ISSN:0009-3157

 

年代: 1980

 

DOI:10.1159/000237903

 

出版商: S. Karger AG

 

关键词: 9-(S)-(2;3-Dihydroxypropyl)adenine;6-Azauridine;Combination of antiviral substances;Vaccinia virus

 

数据来源: Karger

 

摘要:

Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in this paper, 3 showed medium activity against vaccinia virus, but none of them was as effective as (S)-DHPA in combination with AzUrd.

 

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