Immunological diagnosis of multiple myeloma in a medieval bone
作者:
C. Cattaneo,
K. Gelsthorpe,
P. Phillips,
T. Waldron,
J. R. Booth,
R. J. Sokol,
期刊:
International Journal of Osteoarchaeology
(WILEY Available online 1994)
卷期:
Volume 4,
issue 1
页码: 1-2
ISSN:1047-482X
年代: 1994
DOI:10.1002/oa.1390040102
出版商: John Wiley&Sons, Ltd.
关键词: Archaeology;ELISA;monoclonal antibodies;immunoglobulins;IgA;multiple myeloma
数据来源: WILEY
摘要:
AbstractAn inhibition enzyme‐linked immunosorbent assay using monoclonal antibodies has been used to confirm the diagnosis of IgA type multiple myeloma in a small fragment (<10 g) of cranium from a medieval female. Further testing by sodium dodecyl sulphate‐polyacrylamide gel electrophoresis and immunoblotting showed that the IgA was mainly polymeric, suggesting that the individual would have suffered from a hyperviscosity syndrome. This is the first time that immunological assays have been used to diagnose multiple myeloma in ancient human tissue and have permitted speculation on associated clinical sympt
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