Complex Segregation Analysis of Hyperlipidemia in a Seattle Sample
作者:
Wick R. Williams,
J.M. Lalouel,
期刊:
Human Heredity
(Karger Available online 1982)
卷期:
Volume 32,
issue 1
页码: 24-36
ISSN:0001-5652
年代: 1982
DOI:10.1159/000153254
出版商: S. Karger AG
关键词: Hyperlipidemia;Cholesterol;Triglyceride
数据来源: Karger
摘要:
158 Seattle pedigrees selected through hyperlipidemic survivors of myocardial infarction were partitioned into nuclear families with pointers, and complex segregation analysis under a mixed model (major locus and multifactorial transmissible component) was performed on cholesterol and triglyceride measurements. Results confirm the existence of a dominant allele for hypercholesterolemia, whereas for triglyceride segregation of a major locus was not supported. Familial combined hyperlipidemia may be an artefact of multi-trait two-stage selection.
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