Inhibition of Aerobic Glycolysis in Normal and Neoplastic Lymphoid Cells Induced by Lonidamine [1-(2,4-Dichlorobenzyl)-I-H-indazol-3-carboxylic acid]
作者:
Pier Giorgio Natali,
Felice Salsano,
Marina Viora,
Anna Nista,
Walter Malorni,
Alessandro Marolla,
Cesare De Martino,
期刊:
Oncology
(Karger Available online 1984)
卷期:
Volume 41,
issue 1
页码: 7-14
ISSN:0030-2414
年代: 1984
DOI:10.1159/000225879
出版商: S. Karger AG
关键词: Lonidamine;Aerobic glycolysis;Human leukemia
数据来源: Karger
摘要:
The in vitro inhibitory activity of Lonidamine on the aerobic glycolysis of normal as well as leukemic lymphocytes has been investigated. The extent of the impairment of lactate production induced by Lonidamine on normal thymus (T)- and bone marrow (B)-derived lymphocytes was found to be dependent on their source of origin, i.e. residing or circulating pool. Among leukemia tested ‘null’ and B cell leukemias appeared the most affected metabolically by the compound. Administration in vivo of the drug to the patient with B cell chronic leukemia resulted in a decrease of lactate production by leukemic cells comparable to that induced in vitro. These metabolic changes were paralleled in normal, as well as in leukemic cells by ultrastruc-tural lesions, mainly confined to the mitochondrial compartm
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