Sera from multiparous women and renal transplant recipients were screened for the presence of anti‐monocyte antibodies. Reactions caused by anti‐HLA antibodies were excluded by using panel cells that were HLA‐compatible with the antibody producers.Six sera with monocyte‐specific antibodies were identified, and at least two monocyte‐specific (probably allelic) antigens could be recognized.The perspective of the clinical significance of typing for monocyte‐specific antigens i