Angiotensin II Suppkksion of Human Mononuclear Cell React I VI TY is Associated with Enhanced OKT8+Lymphocyie Thymidine Incorporation
作者:
SimonMichael R.,
EngelDavid E.,
We InstockJoel V.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1986)
卷期:
Volume 8,
issue 3
页码: 289-297
ISSN:0892-3973
年代: 1986
DOI:10.3109/08923978609026490
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractRecent evidence suggests that anglotens in II may participate in the regulation of Inflammation. We previously reported that anglotens in II in bits its human peripheral blood mononuclear cell reactivity and acts directly on lymphocytes. These observations are again confirmed. In addition, purified OKT8+but not OKT4+T cell suspensions stimulated with phytohemagg uniting revealed Increased thymidine incorporation when simultaneously cultured for 48 hours with angictensin II. These findings suggest that anglotens in II may Inhibit mononuclear cell thymidlne uptake through stimulator of suppresser lymphocytes contained within the OKTE+subpopulation.
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