A two-step controlled nuclear fusion process utilizing doubly-isotopic boron hydrides (H-2 or H-3 combined with B-11), optionally driven by an e-beam/laser combination, is presented as an optimal approach for energy release via laser driven fusion. Among the large number of possible compounds, B4H10, B5H11, B9H15are listed as suitable analogs, while it remains feasible to select compounds with varying mass ratios of the desired isotopes. In the process primarily laser driven heavy hydrogen fusion is used as initiator for the more economical boron-11 fusion. The optional auxiliary technique, in itself a noteworthy process due to the combination of the e-beam and laser excitation, is of special significance in this case because of the electron deficient nature of the pellet compounds, whose topological properties are indicative of inertial confinement time improvements. No new experimental data on fusion is presented.