This paper offers a preliminary conceptualization of the psychological structure of AIDS‐related attitudes among American adults and describes some of the social and psychological factors that affect those attitudes. Data were collected first from participants in focus groups in five U.S. cities and then from respondents in a national telephone survey. Two major psychological dimensions of attitudes were observed consistently. The first dimension, labeled COERCION/COMPASSION, includes judgments about the extent to which AIDS is viewed as highly contagious and requiring containment, through coercion if necessary. It also includes attributions of blame to people with AIDS. The second dimension, PRAGMATISM/MORALISM, includes judgments about the extent to which AIDS is viewed as controllable through research, public education and governmental sponsorship of behavior‐change programs. The two attitude dimensions are not highly correlated. Regression analyses suggest that the two dimensions have different social and psychological antecedents and that these antecedents differ between White and Black Americans. Using the two factors, a tentative typology of responses to the AIDS epidemic is presented. Implications for AIDS education and policy are discussed.