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Deficit of Cell-Mediated Immunity, Chromosomal Alterations and Defective DNA Repair in a Case of Dyskeratosis Congenita

 

作者: A. Giannetti,   S. Seidenari,  

 

期刊: Dermatology  （Karger Available online 1980）
卷期: Volume 160, issue 2  

页码: 113-117

 

ISSN:1018-8665

 

年代: 1980

 

DOI:10.1159/000250482

 

出版商: S. Karger AG

 

关键词: Immunity;Kariotype;DNA repair;Dyskeratosis congenita

 

数据来源: Karger

 

摘要:

A case of dyskeratosis congenita with depressed responsiveness to policlonal mitogens (PHA, Con-A, PKM) and negative skin tests (PPD, SK-SD, Candidin, Trichophytin) is reported. Chromatid breaks and reduction of the capacity of DNA repair were also present. The findings are discussed in relationship to the prognosis of dyskeratosis congenita.

 

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