Study of HPLC Retention behavior Of 1-Hydroxy-Imidazole-3-N-Oxides, Substituted Imidazoles, and Imidazole Derivatives Using Molecular and Adsorption Parameters
作者:
M.M. Dávila-Jiménez,
M.P. Elizalde-González,
S. García-Díaz,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 1998)
卷期:
Volume 21,
issue 11
页码: 1629-1647
ISSN:1082-6076
年代: 1998
DOI:10.1080/10826079808001249
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
High performance liquid chromatography (HPLC) was applied to study the behavior of a series of 1-hydroxy-imidazole-3-N-oxides (HIO) in solution. Some thermodynamic parameters influencing solute retention were determined from the temperature dependence of the capacity factor (k). A linear relation was derived between k and molecular parameters considering intermolecular association, which was predicted and confirmed. ΔGadsvalues are also highly correlated with connectivity index, molar refractivity and Van der Waals volumes. Retention data for twenty closely related imidazoles were measured and analyzed in relation to hydrophilic parameters.
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