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Immunoglobulin deposition in membranous glomerulonephritis: immunofluorescence and immuno‐election microscopy findings

 

作者: D. R. DAVIES,   J. R. TIGHE,   A. J. WING,   N. F. JONES,  

 

期刊: Histopathology  （WILEY Available online 1977）
卷期: Volume 1, issue 1  

页码: 39-52

 

ISSN:0309-0167

 

年代: 1977

 

DOI:10.1111/j.1365-2559.1977.tb01643.x

 

出版商: Blackwell Publishing Ltd

 

关键词: membranous glomerulonephritis;immunoglobulin;immunofluorescence;immunoperoxidase;immuno‐electron microscopy

 

数据来源: WILEY

 

摘要:

In a series of 250 renal biopsies (transplants excluded) the diagnosis of membranous glomerulonephritis was made in 22. This was done on light microscopy in 17, while the addition of immunofluorescence enabled the diagnosis to be made in a further five. Electron microscopy confirmed the diagnosis in all cases. Immunoperoxidase studies emphasized the basement membrane distribution of the deposits of immunoglobulin and the relative sparing of the mesangium. They showed at an ultrastructural level the presence of IgG in the deposits.

 

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