Facile optical resolution of amino acid esters via hydrolysis by an industrial enzyme in organic solvents
作者:
Tatsuro Kijima,
Kouji Ohshima,
Hideo Kise,
期刊:
Journal of Chemical Technology&Biotechnology
(WILEY Available online 1994)
卷期:
Volume 59,
issue 1
页码: 61-65
ISSN:0268-2575
年代: 1994
DOI:10.1002/jctb.280590110
出版商: John Wiley&Sons, Ltd.
关键词: optical;resolution;amino acid ester;hydrolysis;Alcalase;protease;organic solvent
数据来源: WILEY
摘要:
AbstractRacemic amino acid esters were optically resolved via hydrolysis in organic solvents by the catalysis of an industrial alkaline protease, “Alcalase”. The products which were composed mainly of L‐amino acids were insoluble and easily separated by filtration. The activity of the enzyme and enantiomeric excess of the products were significantly dependent on the nature of solvent and the water content in the reaction media. Generally, high values of enantiomeric excess were obtained at low water contents. Many natural and unnatural amino acids were resolved by this m
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