Recurrence of Epithelial Ovarian Carcinoma after Clinical Remission
作者:
Fumitaka Kikkawa,
Michiyasu Kawai,
Kimio Mizuno,
Hisatake Ishikawa,
Masayoshi Kojima,
Osamu Maeda,
Koji Tamakoshi,
Nobuhiko Suganuma,
Yutaka Tomoda,
Sen-Ei Hattori,
Kazuo Kuzuya,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1994)
卷期:
Volume 38,
issue 1
页码: 65-69
ISSN:0378-7346
年代: 1994
DOI:10.1159/000292449
出版商: S. Karger AG
关键词: Recurrence;Ovarian carcinoma;Remission
数据来源: Karger
摘要:
One hundred and eighty-eight patients with epithelial ovarian carcinoma were treated with primary cytoreductive surgery and subsequent combination chemotherapy. The first recurrent findings such as sites and disease-free interval were analyzed in 141 patients who were clinically remitted 6 months after operation or chemotherapy. Fifty-seven cases had a recurrence. Five-year disease-free survival rates were 75, 72, 29, and 0% in stage I, II, III, and IV, respectively. Twenty-one of 22 patients with > 2 cm maximun residual tumor died, although they once achieved clinical remission. Significant differences were observed between histologic types, and the disease-free survival rate was lowest for serous cystadenocarcinoma. Nine of 15 stage IV patients with serous histology experienced remission, but none of the 8 in stage IV with other histologies did so, suggesting that serous adenocarcinoma is sensitive to chemotherapy and conducive to clinical remission. However, all stage IV patients in remission encountered a recurrence. Intra-abdominal cavity and lymph node were frequently the initial recurrent sites (38 and 27%, respectively). On the other hand, the incidence of distant recurrence was as high as 27%, and 8 of 16 cases with distant recurrence were stage I. Survival time after recurrence was not different among initial sites of recurrence and mean survival time was 15 months.
点击下载:
PDF
(2152KB)
返 回