Concentrations of Isotretinoin and the Arotinoid Ro 15-0778 in Plasma and Tissues of Hamsters and Rats
作者:
Floie M. Vane,
Sarita S. Chari,
James F. Hurley,
Stanley S. Shapiro,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1988)
卷期:
Volume 1,
issue 4
页码: 237-245
ISSN:1660-5527
年代: 1988
DOI:10.1159/000210781
出版商: S. Karger AG
关键词: Isotretinoin;Ro 15-0778;Retinoid;Skin concentrations;Plasma concentrations;Acne;Metabolism
数据来源: Karger
摘要:
The arotinoid Ro 15-0778 is a potent inhibitor of sebum secretion in rodents but not in humans, while isotretinoin (13-cis-retinoic acid, Accutane®) inhibits sebum secretion in rodents and humans. The concentrations of Ro 15-0778 and isotretinoin were determined in plasma and target tissues of castrated, testosterone-stimulated hamsters after oral and topical dosing and in castrated, testosterone-stimulated rats after oral dosing. Comparison of this concentration data to that obtained in the plasma and sebum of humans after dosing with Ro 15-00778 and with isotretinoin did not explain why Ro 15-0778 was a potent inhibitor of sebum production in rodents but not in humans
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