Tolbutamide treatment of pregnant mice: Repeated administration reduces fetal lethality
作者:
Robert J. Belisle,
Sally Y. Long,
期刊:
Teratology
(WILEY Available online 1976)
卷期:
Volume 13,
issue 1
页码: 65-70
ISSN:0040-3709
年代: 1976
DOI:10.1002/tera.1420130111
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractPretreatment of pregnant BALB/c mice with several low doses of tolbutamidc protected against the fetolethal effects of a high dose. Pregnant mice were given single ip injections of 400 mg/kg in saline on day 13; 100 mg/kg/day on clays 10, 11, 12, and 13; or 100 mg/kg/day on days 10, 11, and 12 and 400 mg/kg on day 13. On day 16 the single‐treatment group had a significantly higher resorption rate than any other group. Fetolethality was not related to hypoglycemia. The protective effect of pretreatment may have been due to induction of maternal microsomal enzyme
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