首页   按字顺浏览 期刊浏览 卷期浏览 Tolbutamide treatment of pregnant mice: Repeated administration reduces fetal lethality
Tolbutamide treatment of pregnant mice: Repeated administration reduces fetal lethality

 

作者: Robert J. Belisle,   Sally Y. Long,  

 

期刊: Teratology  (WILEY Available online 1976)
卷期: Volume 13, issue 1  

页码: 65-70

 

ISSN:0040-3709

 

年代: 1976

 

DOI:10.1002/tera.1420130111

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

数据来源: WILEY

 

摘要:

AbstractPretreatment of pregnant BALB/c mice with several low doses of tolbutamidc protected against the fetolethal effects of a high dose. Pregnant mice were given single ip injections of 400 mg/kg in saline on day 13; 100 mg/kg/day on clays 10, 11, 12, and 13; or 100 mg/kg/day on days 10, 11, and 12 and 400 mg/kg on day 13. On day 16 the single‐treatment group had a significantly higher resorption rate than any other group. Fetolethality was not related to hypoglycemia. The protective effect of pretreatment may have been due to induction of maternal microsomal enzyme

 

点击下载:  PDF (428KB)



返 回