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Pharmacogenetic Study with Diazepam in Twins

 

作者: Martin Alda,   Marta Dvořáková,   Marie Pošmurová,   Marie Baliková,   Petr Zvoiský,   Václav Filip,  

 

期刊: Neuropsychobiology  （Karger Available online 1987）
卷期: Volume 17, issue 1-2  

页码: 4-8

 

ISSN:0302-282X

 

年代: 1987

 

DOI:10.1159/000118332

 

出版商: S. Karger AG

 

关键词: Diazepam;Memory;Pharmacogenetics;Twin study

 

数据来源: Karger

 

摘要:

In a study with healthy volunteers (6 monozygotic and 4 dizygotic twin pairs) we followed up diazepam serum levels and psychotropic effects of diazepam after single-dose administration. We found that pharmacokinetic properties of diazepam as well as its influence on memory and performance are probably not under genetic control. On the other hand, genetic factors seem to contribute to effects of diazepam on affectivity.

 

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