Effect of Recombinant Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) on Leukopenia in AIDS: A Study of Seven Cases
作者:
O.G. Ottmann,
F.-D. Goebel,
A. Ganser,
J.R. Bogner,
G. Seipelt,
M. Chatterjee,
E.B. Helm,
D. Hoelzer,
期刊:
Onkologie
(Karger Available online 1991)
卷期:
Volume 14,
issue 4
页码: 319-321
ISSN:0378-584X
年代: 1991
DOI:10.1159/000216999
出版商: S. Karger GmbH
关键词: Colony-stimulating factor;AIDS;Leukopenia;GM-CSF
数据来源: Karger
摘要:
Seven neutropenic patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) were treated with recombinant human GM-CSF in an attempt to reverse their leukopenia. Overall, treatment was associated with a rapid, substantial increase in neutrophilic granulocytes and a smaller increment in eosinophils and monocytes. No significant increase in platelets or reticulocytes was observed. Termination of treatment was associated with a rapid drop in the leukocyte count. While some patients with severely hypoplastic marrows did not respond to GM-CSF treatment, azidothymidine- or ganciclovir-induced neutropenia was reversed by concomitant administration of GM-CSF in others. This indicates that rhGM-CSF may be a valuable adjunct to antiviral therapy in ARC/ AIDS and requires further testing in controlled trials.
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