摘要:
Analysis of weak interactions involving fluorine: a comparative study of crystal packing of some benzodiazepinone drug intermediates and their non-fluorinated analogues M. D. Prasannaa and T. N. Guru Row*ab a Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India. E-mail: ssctng@sscu.iisc.ernet.in b Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560 012, India Received 30th May 2000, Accepted 9th August 2000, Published 18th August 2000 Weak interactions involving fluorine have been analyzed in terms of altered packing modes in the crystalline lattice in four benzodiazepinone drug intermediates which are determined by X-ray diffraction. Two of them are non-fluorinated and the other two are corresponding mono-fluorosubstituted derivatives.The compounds are 2-chloroacetamido-5-chlorobenzophenone (C 2H-1,4-benzadiazapin-2-one (C (C15H11ClN2OF). The conformational features in the first two compounds are essentially governed by strong intramolecular interactions. Specific C–H···F intermolecular interactions along with C–H··· interactions generate altered packing modes in fluorinated intermediates. The latter two compounds have strong N–H···O intermolecular hydrogen bonds as well. 15H11Cl212 FKORURDFHWDPLGRFKORUR IOXRUREHQ]RSKHQRQH &15H10Cl2FNO2), 7-chloro-1,3-dihydro-5-phenyl- 15H12ClN22 DQG
ISSN:1466-8033
DOI:10.1039/b004241m
出版商:RSC
年代:2000
数据来源: RSC