摘要:

Subject Index Page numbers only are given except for ‘Hot off the press’ articles for which issue numbers are also given (in parentheses). A A21459A 423 A21459B 423 abelomycin dehydro- 53 1 abeotaxane 252 abienol 133 Abies balsamea monoterpenoids 479 Abies grandis diterpenoids 135 monoterpene cyclases 119 Abies koreana lignans 52 Abies mariesii lignans 52 57 Abies marocana oligomeric lignans and neolignans 69 Abies pinsapo lignans 52 oligomeric lignans and neolignans 69 abietadiene 135 abietanes 249-250 abieta-8,1I 13-trien- 18-oic acid 15,16-dihydroxy- 249 abietic acid 135 250 abietic acid dehydro- NMR 249 rearrangement 249 abietic acid 15-hydroperoxydehydro- 249 Abraxas grossulariata sarmentosin 84 abscisic acid 132 analysis 146 abscisic acid fluoro- 146 1’,4’-trans-abscisic acid diol 132 Absidia glauca HMG-CoA reductase 1 12 abutiloside A 199 abyssinine-C 79 Acangelisia gusanlung berberines 392 secoberberines 393 Acanthella carteri hanishenol B iii(3) Acanthella cavernosa diterpenoids 254 Acanthopanax koreanum diterpenoids 250 Acanthoscelides obtectus essential oils 478 acarbose 445 Acaryochloris marina secondary metabolites 461 ACC oxidase 324 accuminolide 245 acetaldehyde oxime p-hydroxyphenyl- biosynthesis 366 acetamidine,N-[3-(aminomethyl)benzyl]- NO synthase inhibition vii(3) acetate fluoro- biosynthesis v(4) acetic acid hydroxy- biosynthesis 360 acetic acid 3’-hydroxy-y-ionylidene-,146 acetic acid iodo- 88 acetic acid phenyl- biosynthesis 360 acetic acid 2-O-sulfate phenyl- iv(4) acetogenins 267 iv(2) acetone neryl- 145 acetone phosphate dihydroxy- biosynthesis 113-1 14 acetophenone 84 acetophenone 2,4-dihydroxy- biosynthesis 553 acetophenone 3,4-dihydroxy- 95 acetophenone 2,6-dihydroxymethoxy- 94 acetophenone p-hydroxy- 93,95 acetovanillone 93 acetyl CoA carboxylase fatty acid biosynthesis 336-337 339 345 acetyl CoA:salutaridinol-7-O-acetyl-transferase.362 acetylenic acids brominated 270 Acherantia atropus tropane alkaloids 84 Achillea crithmifolia monoterpenoids 479 Achillea fragrantissima monoterpenoids 479 Achillea nobilis monoterpenoids 485 sesquiterpenes 156 Achilleapratensis sesquiterpenes 153 Achillea ptarmica monoterpenoids 494 Achyranthesfauriei oleanane saponins 672 achyranthosides 672 acids synthesis from nitriles Rhodococcus rhodochrous v(4) aclacinomycin A 100 acoforine 192 aconitine 191 192 aconitine deoxy- 192 aconitine N-oxide NMR 195 Aconitum callibotryon aporphines 397 Aconitum carmichaeli alkaloids 19 1 Aconitumfirmum aporphines 397 Aconitum hemslevanum alkaloids 191-192 Aconitum nagarum alkaloids 192 Aconitum spp.diterpenoid alkaloids 19 1 Aconitum vilmorinianum alkaloids 192 Aconitum vulparia aporphines 397 acorane 148-149 acoren-7a-01 148 ACP -see acyl carrier protein Acremonium spp. halymecins 461 acridine octahydro- 484 9( 10)-acridone X-ray crystal structure 19 acridone 1,3-dihydroxy- 10-methyl- 6 15 acridone 1,3-dihydroxy-N-methyl-,366 acridone 1,3,5-trihydroxy-2,4-diprenyl-, 6 14 acridone 1,3,5-trihydroxy- 10-methyl- 615 acridone 1,3,5-trihydroxy-N-methyl-, 614 acridone alkaloids 11-20 18-20,605-618 614-617 biological studies 616-61 7 biosynthesis 366 isolation and detection 6 15 occurrence 18-19,614-616 structures 18-19 614-616 synthesis 616-617 acridone synthase 366 acrifoline 615 acrignine-A 18 acrignines 61 5 acrimarine-F 6 17 acrimarine-N 18 acrimarines 61 5 acronycidine 11 acronycine 19 6 16 acronycine des-N-methyl- 616 acron ycine 1-oxo- 1,2-dihydro- 12-demethyl- 12- hydroxy- 615 acronydine 11 acrophyllidine 14 Actaea spicata aporphines 397 actamycin biosynthesis 441 actein 26-deoxy- 663 actinidine 85 actinidiolide dihydro- synthesis 158 Actinobacteria marine secondary metabolites 453 actinodaphnine 397 Actinodium cunninghamii monoterpenoids 479 Actinomadura spp.secondary metabolites 462 Actinomadura verrucosospora esperamicin 104 polyketides 533 541,542 actinomycetes fatty acid biosynthesis 353 phenazines 446 Actinoplanes spp. acarbose 445 bisindole alkaloids 423 Actinopygia agassiza triterpenoids 663 actinorhodin 526 Actinosynnemapretiosum ansamitocin 440 445 Acubaria undulata metabolites 28 1 acuminatuside 508 acyclodidemnin A 290 acyl ACP synthase fatty acid biosynthesis 338-339 acyl ACP thioesterases fatty acid biosynthesis 338 acyl carrier protein fatty acid biosynthesis 337 acyl CoA ACP transacylase fatty acid biosynthesis 337 acyl CoA:6-aminopenicillanic acid acyltransferase 368 Adalaria loveni metabolites 288 triterpenoids 664 Adalia bipunctata pyridone alkaloids 641 Adalia decempunctata pyridone alkaloids 641 adalinine 641 Adenocalymma alliaceum triterpenoids 674 Adenocarpus complicatus pyrrolizidine alkaloids 658 adenosine 198 Adenosma bracteosum monoterpenoids 479 Adenostyles alliariae pyrrolizidine alkaloids 65 8 Adenostyles glabra pyrrolizidine alkaloids 658 adenosylmethionine synthetase vi( 1) Adesmia aconcaguensis triterpenoids 675 Adhatoda vasica quinazoline alkaloids 16 613 Adina rubella triterpenoids 675 adlumidine 394 adociaquinones 279 Adocia spp.metabolites 279 adonixanthin-b-D-glucoside,26 1 adouetine-X N-desmethyl- 77 adouetine-Y’ 77 adouetine-Z 79 adoxosidic acid 121 adriamycin 99 adunctins 486 Aedes aegyptii diterpenoids 246 Aegle marmelos coumarins 465,466 aeglin 465 Aenictus spp. methyl anthranilate 85 Aeollanthus buchnerianus hydroxy fatty acids 93 aeruginosin iv(4) aesculetin 470 Aesculus hippocastanum monoterpenoids 479 A-factor streptomycetes 525 affinisine 565 aflatoxins 482 546 1-1 africanane 150-1 5 1 Alangiumpremnifolium sesquiterpenoids allodolicholactone synthesis 507 Afromomum pruinosum monoterpenoids I45 alloeophyllin 155 479 alanine isotope-labelled synthesis 205-2 12 allopumiliotoxin 267A 30 A fromum melegneta termite an tifeedan t alanine P-chloro- deutenated synthesis 214 all opumil io tox in 3 3 9A 30 activity 90 alanine 2,5-dihydrophenyl- biosynthesis allopumiliotoxins 29,623 Agaricus bisporus fatty acids 166 433 allothreonine synthesis 21 3 agarospirol synthesis 153 alanine phenyl- biosynthesis 433 alloyohimbane synthesis 565 Agelas clathrodes metabolites 270 alatoside-1 509 allyl alcohol 3,3-dimethyl- biosynthesis Agelas conifera metabolites 270 albene synthesis 148 59 1 agelasimine-A synthesis 279 albicanal 147 allylic acetoxylation androst-5-en- 17-one agelasimine-B synthesis 279 albicanol 287 374 agelasine A 279 synthesis 147 allyl p-methoxybenzoate oxidation 583 Agelas longissima metabolites 270,276 albine 33 35 almazole E 414 278 Albizia lebbeck oleanane saponins 672 Alnus glutinosa brassinosteroids 4 Agelas mauritiana metabolites 279 albiziasaponins 672 aloesaponarin 526 Agelas nakamurai metabolites 279 alboinin iii(3) Aloysia triphylla monoterpenoids 479 Agelas spp.fatty acids 17 1 Albophoma yamanashiensis indole alkaloids Alpinia breviligulata monoterpenoids 479 agelongine 276 42 1 alstonerine deoxy- 566 Agkistrodon halys blomhoffii fatty acids 163 alcyonin acetate 7-deacetoxy- 284 Alstonia angustifolia Aglaia harmsiana triterpenoids 663 Alcyonium aureum metabolites 285 angustimaline iv(2) Aglaia leucophylla triterpenoids 666 Alcyonium fauri monoterpenoid indole alkaloids 565 580 agnuside 509 metabolites 281 alstophylline 565 iv(2) Agrobacterium aurantiacum sesquiterpenes 145 Alstroemeria spp.tuliposides 93 astaxanthin 455 Alcyonium gracillimum metabolites 286 altemicidin 453 metabolites 261 Alcyonium patagonicum metabolites 286 Alternantheraphiloxeroides,oleanane Agrobacterium tumefaciens fatty acid aldecalmycin biosynthesis 544 triterpenoids 67 1 biosynthesis 348 aldohypaconitine 19 1 Alternaria solani polyketides 549 agroclavine synthesis 421 aldosterone synthesis from altemaric acid 549 ailanthoidol synthesis 70 11-deoxycorticosterone 379 alterobactin A 260 ailanthondol 70 alectrol 92 Alteromonas luteoviolacea metabolites 260 ajacine N-oxide NMR 195 aleuritolic acid 672 Alteromonas rava metabolites 259 ajaconine I93 aleuritolic acid 1 P,2a-dihydroxy- Alteromonas spp.rubrenoic acid C 455 ajmalicine 559 2,3-bis(p-hydroxybenzoyl) ester alysin A 247 biosynthesis 365 672 AM-2 77,78 ajmalicinine 559 aleuritolic acid 1 P-hydroxy- 672 amabiline 658 ajmalidine 565 aleuritolic acid 2a-hydroxy- amarogentin-B 509 ajm aline 565-5 68 3-(p-hydroxybenzoyl) esters 672 Amaryllidacae alkaloids 303-308 biosynthesis 365 algae marine secondary metabolites Amathia convoluta metabolites 286 ajmalinine 565 453464 ambelline 304 305 ajugacumbin G 247 Alicyclobacillus acidocaldarius ambelline 1 1-0-acetyl 304 305 Ajuga decumbens diterpenoids 247 cyclohexyl fatty acid biosynthesis 437 amblyone 666 Ajuga reptans 20-hydroxyecdysone iv(4) fatty acid biosynthesis 341 Ambrosia maritima monoterpenoids 479 ajugarin V 2a-hydroxy- 247 shikimic acid v(3) Ambrox synthesis 494 Akebia trifoliata oleanane saponins 672 Alicyclobacillus acidoterrestris amides synthesis from nitriles Rhodococcus aknadicine 400 cyclohexyl fatty acid biosynthesis 437 rhodochrous,v(4) aknadilactam 400 isopentenyl diphosphate 1 13 amino acids aknadinine 400 Alicyclobacillus caldarius pol yketides 536 cnidaria iv( 3) pharmacology 404 Alicyclobacillus cycloheptanicus cycloheptyl isotope-labelled synthesis 205-2 19 aknadinine 1 -nitro- 40 1,404 fatty acid biosynthesis 438 amino acid transferase amino acid synthesis akuammicine 568 Alicyclobacillusspp.206 synthesis 569 570 cycloheptyl fatty acid biosynthesis 438 &(L-a-aminoadipy1)cysteinyl-D-valine 323 akuammicine 19,20-dihydro- 569 fatty acid biosynthesis 336 -related protein 328 synthesis 570 Alisma orientalis triterpenoids 662 synthetase 328 akuammicine 19a,2Oa-epoxy- 568 alismol synthesis 156 1-amino-1-cyclopropanecarboxylicacid akuammidine 565 alizexol A 662 oxidase 323 NMR 565 alkaloid 223A iii(3) aminoDAHP synthesis 441 akuammiline 565 alkaloid 25 1F 30 aminoDHQ synthesis 441 akuammiline deacetyl- 565 alkaloid A58365B 627 aminoglycoside antibiotics biosynthesis akuammiline 16-epideacetyl- 565 alkaloid FK3000 400 368-370 Alalia armata saponins 672 alkaloids 87 3-amino-5-hydroxybenzoicacid synthase alamosenogenin 671 biosynthesis 359-372 Amycolatopsis mediterranei 441-443 alangiobussine 422 diterpenoid 19 1-203 gene 444-445 alangiobussinine 422 pharmacology 196 purification 442 alangiside 2’-0-feruloyl- 395 norditerpenoid 19 1 amino shikimate pathway 543 395 N-oxides 195 amino sugars 100 alangiside,2’-0-feruloyl-O-demethyl-, alangiside,2’-0-feruloyl-2-0-methyl-steroidal 191-203 aminotransferase amino acid synthesis 206 3-O-demethyl- 395 alkanoic acid o-cycloheptanyl- amitinol 85 115 alangiside 2’-0-[4-( 1,3-hydroxypropyloxy- biosynthesis 336 Ammi visnaga coumarins 467 3-0-methy1)cinnamoylI- 395 alkanoic acid o-cyclohexanyl- biosynthesis ammonium chloride alangiside,2-O-methyl-3-0-demethyl-, 395 336 (4-hydroxystyryl)trimethyl- 279 alangiside 2’-0-sinapoyl- 395 alkenes asymmetric dihydroxylation 582 Ammopiptanthus mongolicus alkaloids 34 alangiside,2’-0-sinapoyl-3-0-demethyl- allelopathy 92 Amni visnaga coumarins,‘ 466 395 alliacane 150-1 5 1 amoenolide K 246 alangiside,2’-0-sinapoyl-2-0-methyl-alliacol A synthesis 150 Amomum krevanh monoterpenoids 494 3-O-demethyl- 395 alliacolide synthesis 150 a-amorphane 149 Alangium bussyanum Alliaria petiolata tropaeolin 90 amoxycillin 309 bisindole alkaloids 422 alloaromadendrane biosynthesis from Amphiachyris amoena diterpenoids 246 emetine 395 aromadendrane 158 amphibians alkaloids 2630,623-625 Alangium lamarckii emetine 395 allocryptopine 393,405 amphibine 4 16 Alangiumplatanifolium iridoids 508 allocryptopine 13-OXO- 393 amphibine-H 79 1-2 Natural Products Reports 2997 Amphidinium cartheri dimethylsulfoniopropionate,459 Amphidinium klebsii metabolites 263 Amphidinium spp.metabolites 262 263 sesquiterpenoids 145 amphidinoketides 262 amphidinol 263 amphidinolideN 457 amphidinolides 262 iv(3) Amphidium spp. amphidinolides iv(3) Amphimedeon complanata fatty acids 167 amphimedine 641 Amphimedon compressa fatty acids 166 metabolites 274 Amphimedon spp. amphimic acid A iii(6) pyridone alkaloids 64 1 tryptamines 420 Amphimedon terpenensis fatty acid biosynthesis 344 fatty acids 17 1 amphimic acid A iii(6) amphitoxin 274 amphotericin B 106 mode of action 106 ampicillin 3 17 amurenine 397 Amycolatopsis mediterranei 3-amino-5-hydroxybenzoicacid synthase 441-443 rifamycinB 440 P-amyrin biosynthesis 592 Anabaena circinalis circinamide iv(4) A nabaenaflos-aquae anatoxin biosynthesis 360 fatty acids 165 tropane alkaloids 649 Anabaena spp.fatty acid biosynthesis 339 anabiline synthesis 307 Anadyomene stellata fatty acids 164 metabolites 263 anagyrine 33 34,35,628,629,630 Anagyrus foetida alkaloids 34,35 Analipus japonicus fatty acids 163 anastrephin synthesis 158 anatoxin-a 649 anatoxins biosynthesis 360-36 1 ancistrocladine 4’-O-demethyl- 388 ancistrocladine O-methyl- synthesis 388 Ancistrocladus tectorius naphthylisoquinolines 388 andersobine 193 andibenin B v(3) andilesin A v(3) andirolactone synthesis 494 andrachamine 643 Andrachne aspera piperidine alkaloids 643 andranginine synthesis 577 androgens partial synthesis 377-378 andrographol ide 246 androsta- 1,4-dien- 17-one 3-thioxo- rearrangement 376 5 a-androstane 17P-(N-alkylfomamide)-4-methyl- 4-aza-3-oxo- synthesis 378 5 a-androstane 17P-(N-arylformamide)-4-methyl- 4-aza-3-oxo- synthesis 378 androstan-17-one,2-carbox yethy loxime derivatives synthesis 378 5a-androstan-3-one 17P-acetoxy- la-methyl- dibromination 377 5a-androstan-6-one ethylidene-3a-(dimethylphenyl- si1oxy)- irradiation 375 Subject index 5a-androstan-11-one ethylidene-3a-(dimethylphenyl- si1oxy)- irradiation 375 androst-4-ene hydroboration 374 androst-5-ene-3P 17P-diacetate 7-(4-hydroxyphenyl)- synthesis 378 androst-4-ene-3,17-dione naphthol complexes 374 4-substituted synthesis 377 androst-4-ene-3,17-dione 7a-acetoxy-6P-azido- aromatase inhibition 377 androst-4-ene-3,17-dione, 6-alkyl- reactions 377 androst-4-ene-3,17-dione, 7-alkyl- synthesis 377 androst-4-ene-3,17-dione, 7-aryl- synthesis 377 androstenedione reaction with trimethylaluminium 375 androst-5-en- 17-one allylic acetoxylation 374 androst-5-en- 17-one 3P-acetoxy- conversion into digitoxigenin 380 androst-1-en-3-one 4P 17-dihydroxy- synthesis 377 Anemia phyllitidis gibberellin biosynthesis 25 1 Anemoclema glaucifolium saponins 672 anemoclemosides 67 1 Anemone spp.fatty acids 164 Aneura pinguis pinguisone 13 I sesquiterpenes 158 Angasomyrtus salina monoterpenoids 479 Angelica decursiva monoterpenoids 479 Angelica edulis coumarins 466 edulisin VI 467 Angelica gigas coumarins 465,466,467 decursin 465 Angelicapubescens coumarins 466 Angelica shikokiana coumarins 467 Angelica spp.coumarins 465 Angelica tuhou coumarins 465 angelicin synthesis 467,468 angelitriol 466 angelols 466 angucycline antibiotics 108 anguibactin 455 angustifoline 34,35 629 630 NMR 631 angustifolioside-A 508 angustifolioside-B 508 angustimaline iv(2) angustine dihydro- synthesis 416 Aniba canelilla monoterpenoids 479 animals alkaloids 658 animal interactions chemical ecology 83-86 chemical defence 84-85 fatty acid biosynthesis 349-353 polyketides 553 anisatin 148-149 Anisocycla jollyana aporphines 397 bisbenzylisoquinolines 390 anisotine 16 anisotine 3-hydroxy- 16 annasterol sulfate 28 1 Annona cherimola cheimoline iii(6) Annona muricata muridienin iv(2) Annona reticulata aporphines 397 oxoaporphines 399 Annona senegalensis aporphines 397 oxoaporphines 399 Annona spinescens benzylisoquinolines 389 berberines 392 Annona squamosa monoterpenoids 479 annonelliptine synthesis 389 Anogeissus acuminata lignans 46,52 anolignan C 52 anolignans 46 Anomala octiescostata buibailactone 85 anomalin configuration 467 anonaine 397 pharmacology 399 ansamitocin 440,445 biosynthesis 441 ansamycins biosynthesis 440 ansatrienin biosynthesis 433436,441 antazirine 270 Anthelia glauca diterpenoids 253 metabolites 285 antheliatin 253,285 Anthonomus grandis antifeedant activity 89 anthosamines 277 Anthosigmella spp metabolites 277 anthracyclines 99-101 anthranilate synthase 366 phenazine biosynthesis Pseudomonas spp.448 anthranilic acid biosynthesis 433 N-methylation 366 anthraquinone-2-carboxylicacid 3,8-dihydroxy-1-methyl- synthesis 526 anthraquinones 83,60 1 biosynthesis 592 isopentenyl diphosphate isomerase 598 antibiotic K-582A biosynthesis 328 antibiotic K-582B biosynthesis 328 antibody directed catalysis 10 1 antibody directed enzyme-prodrug therapy 101 Antidesma montana cyclopeptide alkaloids 80 antiferritin antibodies vi(5) antillatoxin 262,454 antiaquine 390 antiprogestins synthesis 379 Antirhea lucida bisindole alkaloids 422 antirrhinoside 86 123 Antirrhinum majus iridoids 123 antirrinide 6P-hydroxy- 508 7,8-epi-antirrinoside 508 antirrinoside 5-O-allosyl- 508 antofine 6-O-desmethyl- 3 1 antrocin 146 Antrodia cinnamomea sesquiterpenoids 146 ants alkaloids 26-30 623-625 apatite hydroxy- 88 apetatolide structure 470 Aphelandra tetragona aphelandrine biosynthesis 366 aphelandrine biosynthesis 366 aphidicolane 3a 16P-dihydroxy- 25 1 aphidicolanes 25 1 aphidicolin 25 1 synthesis 377 Aphiporus angulatus metabolites 294 aphyllidine 34 aphylline 33,631 Apiaceae spp.monoterpenoids 477 Apis mellifera feeding deterrents 92 Apium graveolens brassinosteroids 2,4 sedanenolide 89 aplasmomycins 453,525 biosynthesis 535 aplidiamine iv(3) Aplidiopsis spp.aplidiamine iv(3) aplidites 290 Aplidium longithorax longithorones iii(5) Aplidium spp. metabolites 290 Aplisina archeri fatty acids 165 aplyparvunin structure 287 aplyronines 287 Aplysia dactylomela metabolites 287 sesquiterpenes 148 Aplysiapawula metabolites 287 aplysiatoxin 454 aplysiatoxin debromo- 262,454 aplysillamides 270 aplysillin 277 Aplysinafistularisfulva,metabolites 277 Aplysis kurodai metabolites 287 apocodeine 2-fluoro- pharmacology 403 10’-apo-fucoxanthinal 263 12-apo-fucoxanthinal 263 12’-apo-fucoxanthinal 263 9’-apo-fucoxanthinone 263 1 3 ’-apo- fucoxanthinone 263 apogeissoschizine synthesis 562 apogeissoschizine 2,7-dihydroxy- synthesis 562 apogeissoschizine tetrahydro- synthesis 562 Apollonias barbujana lignans 54 apomorphine pharmacology 399 apomorphine 2-fluoro- pharmacology 403 apopinene synthesis 496 aporphines 397-399 dimeric 399 aporphines dioxo- 399 aporphines 0x0- 399 aporphinoid alkaloids 396-400 apotirucallanes 668 apovincine synthesis 578 appar icine 57 2-5 7 3 aquamycin biosynthesis 532 Aquilaria agallocha sesquiterpenes 155 Arabidopsis spp.brassinosteroids 5 fatty acid biosynthesis 347 Arabidopsis thaliana brassinosteroids 4 8 camalexin 94 diterpenoids 136 138 farnesyl diphosphate synthase 1 14 fatty acid biosynthesis 347 geranylgeranyl diphosphate synthase 1 15 HMG-CoA reductase 112 HMG-CoA synthases 1 12 arachidonic acid 164 biosynthesis 346,351 C-isotope labelled synthesis 173 arachidonic acid hydroxy- biosynthesis 344 arachidonic acid methylidene- synthesis 167 Arachis hypogaea phytoalexins 95 Arachisparaguaensis phenolics 87 aradecoside 67 2 aragusterols synthesis 281 382 Aralia armata oleanane saponins 672 Aralia bipinnata quinoline alkaloids 1 1 Aralia decaisneana oleanane saponins 672 Aralia elata oleanane saponins 672 aralionine-B 77 arbutin 93 Arbutus unedo iridoids 508 Archaea fatty acid biosynthesis 343 Archaebacteria secondary metabolites 455 Archangelica officinalis coumarins 465 Archangium gephyra quinoline alkaloids 607,609 Archilejeunea olivacea olivacene iv(3) arctigenin 44 Arctium lappa oligomeric lignans and neolignans 69 arcyroxocin A synthesis 425 ardeemin 17 18 ardeemin N-acetyl- 17 arenaranA 146 arenarans 279 arenarol 278 synthesis 147 arenastatin A 270 arginine clavulanic acid biosynthesis 320 isotope-labelled synthesis 2 15-2 17 arginine N2-acetyl- cephalosporin assay 328 arginine 4-hydroxy- biosynthesis 360 arglabin structure 156 argophyllin A 86 argyrolobine 34 Arillastrum gummiferum monoterpenoids 479 Arisarum vulgare pyrrolidine alkaloids 638 aristeromycin biosynthesis 369 aristolactam B-111 7-methoxy- 400 aristolactam I 9-hydroxy- 400 aristolactams 400 aristolane 157-1 58 aristolochene 125 aristolochene synthase 125 Aristolochia arcuata berberines 392 Aristolochia asclepiadifolia monoterpenoids 479 Aristolochia cinnabarina aristolochic acids 400 Aristolochia debilis sesquiterpenes 158 Aristolochia macrophylla diacylglycerol galactoside 90 A ristolochia manchurensis aristolochic acids 400 Aristolochia ovalifolia monoterpenoids 479 Aristolochia tubiflora aristolochic acids 400 aristolochic acids 84,90,400 binding to DNA 659 Aristotelia alkaloids 559 arjunolic acid 95 arjunolic acid 3-coumaroyl- 67 1 armatoside 672 armentomycin biosynthesis 37 1 armepavine 389 Arnebia euchroma lignans 44 Arnica angustifolia diterpenoids 245 sesquiterpenes 157 aromadendrane 157-1 58 biotransformation to alloaromadendrane 158 aromadendrene 133 aromatase inhibition 377 inhibitors synthesis 373 artabotrine 399 Artahotrys zeylanicus dioxoaporphines 399 oxoaporphines 399 arteannuin-B 128 arteether 149 artemeseole synthesis 485 Artemisia absinthum monoterpenoids 479 483 Artemisia annua arteannuin-B 128 monoterpenoids 479 sesquiterpenes 149 Artemisia argenta monoterpenoids 479 Artemisia dracunculus oviposition deterrents 9 1 Artemisia glabella sesquiterpenes 156 Artemisia gmelinii monoterpenoids 479 Artemisia hedini sesquiterpenes 153 Artemisia maritima monoterpenoids 479 Artemisia phaeolepis sesquiterpenes 152 Artemisia roxburghiana monoterpenoids 479 Artemisia salsoloides monoterpenoids 482 Artemisia sieberi monoterpenoids 479 494 Artemisia spp.monoterpenoids 479 Artemisia thuscula monoterpenoids 479 artemisinin 128 artemisinin P-dihydro- 149 artemisyl 485-486 arthrichitin v( 1) Arthriniumphaeospermum arthrichitin v( 1) Arthrohacter spp. fatty acid biosynthesis 34 1 artimisinin determination 149 Arum maculatum dimethyl disulfide 91 indole 91 Arundo donax antifeedant activity 89 Asarina scandens terpenoids 86 asarinin synthesis 56 asarinin 2’-hydroxy- 54 asarinol-C 477 asarinol-D 477 Asclepias curassavica flavonoids 90 oviposition stimulants 91 Ascochytapinodes pinolidoxin 92 Ascochyta pisi ascosalitoxin 93 ascomycin 536 biosynthesis 436 ascosalitoxin 93 Asiasarum sieboldi monoterpenoids 477 asimilobine 397 askendoside F 663 Aspalathus linearis phenylpyruvic acid glucoside v(2) asparagine isotope-labelled synthesis 2 1 5-2 1 7 aspartase amino acid synthesis 21 5 aspartic acid isotope-labelled synthesis 214-215 Aspergillus flavus monoterpenoids 482 polyketides 546 Aspergillus fumigatus metabolites 261 quinazoline alkaloids 612 tryptamines 418 tryptoquivaline alkaloids 461 Aspergillus giganteus carotenoids 601 Aspergillus japonicus asperparaline A iv(6) Aspergillus nidulans fatty acids 167 Aspergillus niger cyclopeptide alkaloids 80 fatty acids 164 monoterpenoids 482,487 Aspergillus ochraceus chlorocarolides 46 1 Aspergillus parasiticus polyketides 546 547 Aspergillus terreus polyketides 546 Aspergillus variecolor andibenin B v(3) sesterterpenoids 141 asperperaline A iv(6) asperuloside 508 asperuloside 6’-@p-~-glucosyl- 508 aspidofi-actinine 573 Aspidosperma ramiforum monoterpenoid indole alkaloids 559,579 aspidospermidine 573 synthesis 575 aspidospermidine 1,2-didehydro- synthesis 575 aspidospermidine N,-ethyl- synthesis 575 aspidospermine 573-577 asp id0 sperm io se 57 3 astaxanthin 455 astaxanthin-P-D-glucoside,260 astellatol 141 Asteraceae alkaloids 657,658 Asteraceae spp.fatty acid biosynthesis 348 Aster batangensis oleanane saponins 672 1-4 Natural Products Reports 2997 asterbatanosides 672 Aster hellidiastrum oleanane saponins 672 Aster farreri monoterpenoids 485 astericane 150-1 5 1 Asterolasia trymalioides coumarins 466 47 1 Aster tataricus monoterpenoids 498 Aster yunnanensis oleanane saponins 672 asteryunnanosides 672 astragalosides 663 Astragalus adsurgens triterpenoids 663 Astragalus alopecurus triterpenoids 663 Astragalus hoeticus swainsonine 23 Astragalus deflexa swainsonine 23 Astragalus dissectus triterpenoids 663 Astragalus ephemerotorum triterpenoids 663 Astragalus garhancillo swainsonine 23 Astragalus illini swainsonine 23 Astragalusjunin swainsonine 23 Astragalus kulahensis triterpenoids 663 Astragalus lentiginosus swainsonine 24 Astragalus memhranaceus triterpenoids 663 Astragalus mollissimus swainsonine 24 Astragaluspehuenches swainsonine 23 Astragalus polycanthus alkaloids 196 polycanthisine 30 Astragalus spp.swainsonine 23 triterpenoids 663 Astragalus strictus swainsonine 23 Astragalus laschkendicus triterpenoids 663 Astragalus trigonus triterpenoids 663 Astragalus variahilis swainsonine 23 Astroloma humifusum iridoids 508 Astropecten latespinosus metabolites 294 asukamycin 445 biosynthesis 434,445-446 atalaphylline N-methyl- 614,615 atalaphyllinine N-methyl- 614,615 atamestane synthesis 377 atanine 1 I 13 ATCC 20928-B 146 atheroline 399 atherospermidine 399 3p 16a-atisanediol 279 atisinium chloride 194 atomic force microscopy vi(5) atracurium physiology 389 atrenorin 84 Atrichum undulatum coumarins 466,47 1 472 Atropa belladonna tropane alkaloids 92 atropcangorosin A iv(3) aucherine 658 aucubin 9 1 122 509 aucubin 10-deoxy- 123 Augmentin 309,3 12 augustamine synthesis 307 aurachin C 14 aurachin D 14 auranticins 460 aurapten acetoxy- 465 aurapten epoxy- 465 aureolic acids 101-102 auricolic acid 178 Austrahaileya scandens monoterpenoids 479 austrodorin 288 Austrodoris kerguelenensis metabolites 288 Austromyrtus spp.monoterpenoids 479 Austrovenus stutchhuryi metabolites 288 autumnaline,7-O-benzyl-3’-O-methyl- oxidation 404 auxins analysis 146 avarol 5’-acetyl- 278 structure 147 avarol 2’,5’-diacetyl- 278 averantin synthesis 546 averantin 5’-hydroxy- 546 avermectin C-2”-a-fluoro- 102 avermectin C-2”-P-fluoro- 102 avermectin B 1,4”-epi-acetylamino- 4”-deoxy- 102 avermectin CHB 1 538 avermectins 102,537 13-epi-avermectins synthesis 102 Averrhoa carambola monoterpenoids 505 averufin 546 avian liver isopentenyl diphosphate isomerase 597 axamide-4 synthesis 153 axinastatin 1 274 Axinella cannabina metabolites 279 Axinella carteri metabolites 276 axinellamide 270 Axinella spp.metabolites 270 274 Axinella weltneri metabolites 281 triterpenoids 675 axinohydantoin debromo- 276 Axinyssa aplysinoides metabolites 279 sesquiterpenes 149 axisonitrile-4 279 synthesis 153 ayapin 465,470 8b-azaacenaphthylene 634 azaandrostane y-haloalkynyl- antiandrogenic activity 378 azaandrostane y-hydroxy- antiandrogenic activity 378 1 1-azaartemisinin synthesis 149 9-azabicyclo[4.2.llnonane 649 6-azacholest-4-en-3-one, synthesis 383 17-azacholesterol synthesis 383 Azadirachta indica triterpenoids 668 azadirachtin 89 synthesis 668 azadirachtin 1-desacyl- 669 11-azaestrone synthesis 383 azafluoranthenes 400 9b-azaphenalenes 634 9-azastearic acid methyl ester synthesis 170 4-azasteroids synthesis 383 17-azasteroids synthesis 383 azedirachin C 669 azepine alkaloids 637-65 1,647-648 azido sugars synthesis vi(6) azodicarboxamidetributylphosphine NJV,”,”-tetramethyl- Mitsunobu acylation cholestan alcohols 375 baccatin 111 10-deacetyl- 133 252 Baccharis dracunculifolia monoterpenoids 479 sesquiterpenes 149 152 Baccharis latifolia monoterpenoids 479 Baccharis salicifolia monoterpenoids 479 bacillariolides 458459 Bacillariophyceae secondary metabolites 458-459 Bacillus cereus cereulide 455 metabolites 260 monoterpenoids 486 Bacillus megaterium hydroxylation vi( 3) Bacillus pumilus metabolites 260 Bacillus spp.fatty acid biosynthesis 336 Bacillus stearothermophilus farnesyl diphosphate synthase 1 14 115 Bacillus subtilis fatty acid biosynthesis 339 polyketides 535 scutianines.79 bacircines 260 backebergine 387 baconipyrone C 553 bacteria fatty acid biosynthesis 336 marine secondary metabolites 453464 bafilomycin 535 Bahia schaflneri monoterpenoids 486 bakkane 153-155 4-epi-bakkenolide A synthesis 155 bakuchicin 467 Balanus amphitrite diterpenoids 254 Balanus halanoides fatty acids 165 Baleaperversa plant phenolics 84 Ballota aucheri diterpenoids 245 balsamiferone 468 baptifoline 34 36,629,630 bargustanine 390 bastadins 277 batatasin 111 93 batatasin 111 3’-methoxy- 93 batrachotoxin 201 Battus philenor diacylglycerol galactoside 90 batzelladines 274 Batzella spp. metabolites 274 batzelline C synthesis 419 bauerine B 415 Bazzania tridens sesquiterpenes 148 155 bellidiastroside 672 Bellis hernardii oleanane triterpenoids 67 1 bellisonic acid 67 1 Bemesia argentifolii sugar esters 9 1 bengamides 647 benkarlaol iii( 1 ) benzaldehyde 9 1 benzamide 4-hydroxy-3-nitroso- 446 benzamidine p-amino- NO synthase inhibition vii(3) benzastatins 607 609 benzene methoxy- 91 benzene 1,2,4-trimethoxy- 91 benzoic acid biosynthesis 437 benzoic acid 3-hydroxy- biosynthesis 437 benzoic acid p-amino- biosynthesis 539 benzoic acid 3-amino-4-hydroxy- 446 iv(1) benzoic acid 3 -amino-5 -hydroxy- 543 biosynthesis 433,440-443 benzomalvins 6 12 benzo[a]naphthacenequinone,biosynthesis 533 benzophenanthridines 395-396 benzopyrrocolines 391-392 benzoquinone 84 [4,6-b,c]benzothiazepines, steroidal synthesis 377 1,4-benzoxazine-3-0ne 2,4-dihydroxy-7-methoxy- biosynthesis iv(5) benzylisoquinoline alkaloids biosynthesis 361-363 benzyl propionate 84 berbamine 390 berbamunine 390 biosynthesis 361 berbamunine synthase 36 1 berberine 8-0xo- 392 berberine tetrahydro- 392-393 pharmacological effects 393 berberine chloride N-methyldihydro- 392 berberines 392,392-393,394-395 biosynthesis 363 pharmacological effects 393 Berberis aemulans berberines 392 bisbenzylisoquinolines 390 Berheris amurensis aporphines 397 berberines 392 Subject index bisbenzylisoquinolines 390 Berberis candidula berberines 392 Berberis glauca bisbenzylisoquinolines 390 Berberis heterobotrys aporphines 397 benzylisoquinolines 389 berberines 392 bisbenzylisoquinolines 390 Berberis heteropoda berberines 392 Berberis iliensis aporphines 397 berberines 392 Berberis integerrima aporphines 397 benzylisoquinolines 389,390 berberines 392 bisbenzylisoquinolines 390 Berberis numularis aporphines 397 benzylisoquinolines 390 berberines 392 bisbenzylisoquinolines 390 Berberis poirettii berberines 392 bisbenzylisoquinolines 390 Berberis pruinosa berberines 392 bisbenzylisoquinolines 390 Berberis sibirica berberines 392 bisbenzylisoquinolines 390 proaporphines 397 Berberis stolonifera benzylisoquinoline alkaloids 361 Berberis turcomanica aporphines 397 benzylisoquinolines 389 berberines 392 bisbenzylisoquinolines 390 isoquinoline alkaloids 387 388 Berberis virgetorum berberines 392 isoquinoline alkaloids 387 secoberberines 393 Berberis vulgaris aporphines 397 berberines 392 bisbenzylisoquinolines 390 berbermbine 392 berberrubine 8-0xo- 392 bergapten synthesis 469 bernardiosideB4 67 1 berninamycins biosynthesis 370-37 1 bernumicine 390 bernumidine 390 bernumine 390 berpodine 392 bersimosides 672 berteric acid 165 betavulgarin 95 Beta vulgaris betavulgarin 95 brassinosteroids 4 oleanane saponins 672 betavulgarosides 672 beticolins 55 1 Betula ermanii triterpenoids 666 Betulaplatyphylla phenolics 87 Betulapubescens phenolics 87 beyerane 1P-acetoxy- 15a 16a-epoxy- 25 1 beyerenes 135,25 1 bgugaine 638 bharatamine 392 393 bharhingine structure 570 bibenzyl 3,3’,5-trihydroxy- 552 bicoloridine 194 bicoloridine dehydro- 194 bicoloridine alcohol 194 bic yclofamesane 145- 147 bicyclofamesol synthesis 147 1-6 Natural Products Reports 1997 bicyclogennacrane 157-1 58 bicyclo[2.2.1 Iheptanes 27-hydroxylated NMR 498 bicyclo[ 2.2.1 Iheptenes 27-hydroxylated NMR 498 bicyclo[3.2.0]heptenes synthesis 504 bicyclo[2.2.2]octanone synthesis 494 Bidens pilosa diterpenoids 245 bifurcane 265 Bifurcaria bifurcata diterpenoids 245 metabolites 265 2,2’-biguaiazulenyl iii( 1) 2,2’-biindole synthesis 424 bile acids esterification microwaves 374 hydrolysis microwaves 374 partial synthesis 379-380 bilobalide detection 158 binankadsurin angeloyl- 6 1 biondinin A 67 bionidins 5 2 Biota orientalis fatty acids 164 biotin biosynthesis 354 biotin a-methyl- biosynthesis iv( 1) biotin carboxy carrier protein fatty acid biosynthesis 339 biotin carboxylase fatty acid biosynthesis 339 biphenyls 94 bipolal 153-155,461 bipolaramide synthesis 424 Bipolaris spp.bipolal 461 sesquiterpenes 153 bird toxins 88 bisabolane 147-148 P-bisabolene 128 bisabol-3-ene 12-hydroxy-2-oxo- 147 a-bisabolol 487 biscoumarins 473 biscryptolepine 423 3,24-bisepibrassinolide,8 3,24-bisepicastasterone,8 bis(fenchylidene) 505 bisindole alkaloids 421427,57948 1 bis-lactim ethers amino acid synthesis 208 bismagdalenic acid iii(3) bismurrayaquinone A synthesis 424 10,lO’-bisvindoline synthesis 575 bitter acids biosynthesis 592 blacknidine 193 blacknine 193 Blakeslea trispora HMG-CoA reductase 112 Blattella germanica HMG-CoA reductase 112 Bledius arenarius chemical defence 85 Bledius spectabilis chemical defence 85 Bledius spp.chemical defence 84 bleomycin A2 104 bleomycin Az demannosyl- 104 Blepharocalyx salicifolius monoterpenoids 479 blepharodol 673 blepharodol 7a-hydroxy- 673 Bletilla striata polyketides 553 Blumeae membranacea monoterpenoids 479 Blumea lacera triterpenoids 675 blumenol-A 505 boarioside 152 boehmenans 66 boeticol 666 Bohlmann bands 15 boldine 397 pharmacology 399 Bombyx mori fatty acid biosynthesis 35 1 isopentenyl diphosphate isomerase 597 bongkrekic acid 167 Boophilus microplus sesquiterpenes 149 Boraginaceae alkaloids 657-658 borneol glycosylation 498 mass spectra 498 oxidation 498 bornyl acetate synthesis 495 bornyl6-O-P-~-xylopyranosy1- P-D-glucopyranoside 498 boromycin 525 biosynthesis 535 Boronia algida coumarins 466,467 quinoline alkaloids 11 triterpenoids 666 Boronia coerulescens quinoline alkaloids 1 1 Boronia inornata quinoline alkaloids 11 Boronia megastigma sesquiterpenoids 145 borophycin biosynthesis 524 boschnialactone synthesis 507 bosistidine 614,615 bosistine 614 615 Bosistoa transversa acridone alkaloids 6 14 615 Bossiella orbigniana fatty acids 164 Boswellia carterri monoterpenoids 479 Boswellia serrata triterpenoids 674 botrydiane 150 botryllamides 290 Botryllus schlosseri metabolites 290 Botryllus spp.metabolites 290 botryococcene octahydro- 66 1 botryococcenes 125 Botryococcus braunii braunixanthin 1 iv(6) fatty acids 164 1ycapanerol iii( 4) sesquiterpenes 145 sesquiterpenoids 125 Botrytis cinerea 2,6-dihydroxymethoxyacetophenone,94 lettucenin A 95 phytoalexin response 93 sesquiterpenes 150 Bowdichia virgilioides alkaloids 34 brachyaconitine 192 Brachycaudus aconiti alkaloids 192 Brachycaudus napelli alkaloids 192 brasilane 15 7- 158 brasilidineA iii(6) Brassica campestris brassinosteroids 4 lignans 45 Brassicajuncea indole glucosinolates 88 Brassica napus brassinosteroids 1,4 fatty acid biosynthesis 347,348 indole glucosinolates 88 lipases 178 pollination 91 Brassica oleracea phytoalexins 93 Brassica rapa diterpenoids 138 indole glucosinolates 88 brassinin biosynthesis 365 brassinolide 3 5 6 7 8 biosynthesis from campesterol 6-7 discovery 1 structure 2 brassinolide 2-deoxy- 2 structure 2 brassinolide,23-U-~-~-glucopyranosyl- brassinosteroids 1-1 1 biological activities 7-8 biosynthesis 5-8 biosynthesis in intact seedlings 7 biosynthetic mutants 8 2,3-epoxy- synthesis 382 isolation.1-5 metabolism 8 occurrence 1-5 physiological action 5 structures 1 braunixanthin 1 iv(6) brevetoxin-3 263 brevetoxin A 456 brevetoxin B 457 biosynthesis 449 synthesis 263 brevetoxin B 1 288 brevetoxin B3 288 brevianamides vii(4) Brevibacteriumspp. fatty acid biosynthesis 335 brevitaxin 70 249 briarellins 253 285 Briareum asbestinum diterpenoids 253 metabolites 285 Briareum polyanthes diterpenoids 254 metabolites 283 bridgesigenin C 671 bromobactam 3 17 bromocodide 401 bromoxone 294 Broussonetia kazinoki pyrrolidine alkaloids 638 broussonetines 638 brown algae metabolites 264-266 browniine 193 browniine 14-dehydro- 193 browniine 14-O-acetate 193 Brucea antidysenterica quassinoids 669 Brucea javanica quassinoids 669 Brucea mollis tryptamines 41 8 bruceanols 669 bruceol 469 bruceollines 4 18 bruceosides 669 brucine assay 569 Brugmansia candida tropic acid biosynthesis 360 brunsbelline 304,305 Brunsvigia gregaria alkaloids 304 Brunsvigia josephinae alkaloids 305 bryononic acid 672 bryostatin 10 286 bryostatins v( 1) bryozoans metabolites 286 buchapine 606,608 Buddleia spp.sesquiterpenes 150 bufotoxin homologues synthesis 380 Bugula neritina bryostatins,v( 1) metabolites 286 buibailactone 85 bulbocapnine 397 bulgarsenine 658 Bulla gouldiana metabolites 288 bulnesol NMR 156 a-bungarotoxin pharmacology 196 buntanbismine 615 616 buphanidrine 304 305 buphanisine 304 305 307 Bupleurum falcatum monoterpenoids 487 Bupleurum fruticosum coumarins 466,471 Bupleurum salicifolium lignans 48,52 Bupleurum smithii oleanane saponins 672 oleanane triterpenoids 67 1 buprenorphine pharmacology 403,404 burchellin 67 Bursera delpechiana triterpenoids 674 burseran 44 Bursera simaruba lupane triterpenoids 669 busalicifol 52 busaliol 52 butane dibenzyl- 46-48 butanediol dibenzyl- 46-48 butanesulfonyl fluoride n-perfluoro- cholestanol fluorination 375 butanoic acid 4-[2-(2-formylvinyl)-3-hydroxy-5-oxocyclopentyl]- methyl ester 173 butanolactones biosynthesis 353 butanoyl ACP conversion to hexadecanoyl ACP 338 fatty acid biosynthesis 347 butylamine,N-methylbutanoyl2-methyl- 85 butyl isoligustrosidate 508 butyrolactones dibenzyl- 48,48-52 Buxus sempervirens alkaloids iii(4) C Cacospongia cJ linteiformis metabolites 280 Cacospongia mollior metabolites 281 cacospongionolide B 280 cacospongionolide B 25-deoxy- 280 cacospongionolide C 280 cactorein 93 cadalene 2,7-dihydroxy- 128 cadalene 7-methoxy- 1,2-dihydro- 128 149 cadalene 8,9-oxido- 149 cadambine 3a-dihydro- 559 cadensin G 5’-demethoxy- 70 cadina-4,10( 15)-dien-3-one 90 149 cadinanes 149,264 biosynthesis v(6) cadinanolide 130 Gcadinene 128 149 y-cadinene v(5) y-cadinene synthase v(5) Cadlina laevis metabolites 287 cadlinaldehyde iii(6) Cadlina luteomarginata cadlinaldehyde iii(6) metabolites 287 Cadlina pellucida metabolites 287 Caenorhabditis elegans quinoline alkaloids 13 Caesalpinia bonducella caesalpinin iii(6) caesalpinin iii(6) Caesulia axillaris monoterpenoids 479 CAF-603 14-hydroxy- 148 cafestol 250 cagayanin 46 calamenane 5,8-dihydroxy- 149 calamenene 128 calamenene 7-desmethyl-2-methoxy- synthesis 149 calamenene 7-hydroxy- 128 calamenene 10,12-peroxy- 149 Calamintha ashei menthofurans 92 Calamintha grandiflora monoterpenoids 479 Calamintha incana monoterpenoids 487 calanolides 465,470 pharmacological activity 470 structures 469 470 synthesis 470 Calceolaria dentata diterpenoids 25 1 Calceolaria hypericina diterpenoids 249 caledonin 290 calendic acid biosynthesis 346 Calendula officinalis fatty acid biosynthesis 346 calicheamiciny11’lo’ calicheamicins 103-104 calicoferols 285 Calicogorgia granulosa 2,2’-biguaiazulenyl iii( 1) Calipelta spp.callipeltoside A iii(2) callicladol 267,661 callipeltose iii(2) callipeltoside A iii(2) Callisternon linearis monoterpenoids 479 callyspinol 245,279 Callyspongia spinosissima diterpenoids 245 metabolites 279 calonectrin dihydroxy- 127 Calophyllum gracilipes gracilipene iii(5) Calophyllum lanigerum coumarins 466,470 Cal op hy 11um teysmanii coumarins 466,470 soulattrolide 465 Calophyllum teysmanni coumarins 470 calycanthine 427 calycotomine N-methyl- synthesis 387 calystegine A3 84 calystegine A3 649 calystegine Bz 649 calystegine Bz 23,84 87 calystegine B I 3-O-~-~-glucopyranosyl- 649 calystegines 83,648 Calyx niceaensis metabolites 281 Calyxpodatypa metabolites 270,281 camalexin 94 camaric acid 671 camaricinic acid 674 camarilic acid 67 1 camarinic acid 674 Camellia sinensis monoterpenoids 482 cameronic acid 165 campestanol 6 campestanol 6a-hydroxy- 6 campestanol 6-0xo- 6,7 campesterol 5 conversion into brassinolide 6-7 camphanes 498-503 camphanoyl iodide meso diol acylation 503 camphene 120 gas phase transformations 498 camphene w-acetyl- synthesis 498 P-campholenolactone dih ydro- hydroxylation 478 camphonanic acid synthesis 506 camphor 12 1,498 reactions 504 camphor 3-bromo- bromination 499 camphor 9-bromo- reactions 500 camphor 3,3-dibromo- bromination 499 camphor 3,9-dibromo- reactions 500 camphor 3-halo- NMR 498 camphor 4-methyl- synthesis 499 camphor 5-methylene- synthesis 499 camphor thio- irradiation 499 camphor 3,3,8-tribromo- reactions 499 camphorimines synthesis 501 camphorquinone synthesis 499 camphor- 10-sulfonic acid reactions 501 Camponotus hercuteanus 2,4-dimethyl-5-hexanolide,85 Camptotheca acuminata HMG-CoA reductase 1 12 camptothecin 584-588 camptothecin 20-O-acetyl- synthesis 586 camptothecin 7-(2-aminoethyl)- synthesis 587 camptothecin 20-desethyl- synthesis 587 camptothecin 10,l l-ethylenedioxy- synthesis 587 carnptothecin 10-hydroxy- synthesis 586 camptothecin 5-hydroxy- 14-nitro- synthesis 586 camptothecin 10-methoxy- synthesis 584 585 camptothecin,10,11-methylenedioxy- synthesis 587 camptothecin 14-nitro-20-O-acetyl- synthesis 586 canadine synthesis from tetrahydrocolumbamine 363 Subject index canadine chloride N-methyl- 392 Canaga odorata monoterpenoids 479 canarodial 673 canarol 673 canarol 7a-hydroxy- 673 candicidin biosynthesis 539 Candida albicans fatty acid synthetases 346 Candida antarctica monoterpenoids 483 Candida rugosa monoterpenoids 483 candidine synthesis 61 1 Canella winterana sesquiterpenoids 146 canescensterone 200 202 cangorosins structures iv(3) cannabinoids 5 11-5 13 biosynthesis 592 cannabinol hexahydro- 5 11 cannabinol,3-methoxy-A9-tetrahydro- analogue 51 1 cannabinol A’-tetrahydro- 5 1 1 cannabinol A*-tetrahydro- 5 11 cannabisin G 47 cannabisins 67 Cannabis sativa lignans 47 neolignans 67 Cantao parentum monoterpenoids 492 Cantharellus cibarius fatty acids 166 Cantharellus tubaeformis fatty acids 165 canthin-6-one alkaloids 4 18 carbocyclic analogue 4 18 capenosides 664 capensioside 122 Capnella thyrsoidea metabolites 285 Capnella thyrsoides diterpenoids 253 capnine biosynthesis 336 cappodocin 48 Capsicum annuum aristolochene 125 geranylgeranyl diphosphate synthase 115 capsidiol 93 125 Caput nigri triterpenoids 664 carane 3a,4a-epoxy- reaction with formic acid 504 caranes 503-504 caran-2-01 synthesis 504 carazostatin synthesis 413,414 13-~arbaartemisinin synthesis 149 12-~arbaeudistomin 41 6 carbamoyl phosphate synthase crystal structure v(5) carbapenem 309,311 carbazol-3 -one 4b,8 a-dih ydro- synthesis 414 carbazomycin B synthesis 414 carbinolamide 394 carbohydrates biologically active natural products 99-1 10 P-carboline 6-methoxy-2-methyl- 1,2,3,4-tetrahydro- 422 P-carboline tetrahydro- synthesis 578 carboline alkaloids 418 P-carbolines 4 16 carbonic anhydrase binding to hydroxamate inhibitors vii(3) inhibition vii(3) Carcinoscorpius rotundicauda fatty acids 164 Carcinus maenas ecdysteroids 89 cardenolides 83 84 cardinalins iv(4) car-2-ene synthesis 504 car-3-ene 91 120 biosynthesis 117 photolysis 504 car-3-ene synthase 503 carenols synthesis 504 carenones synthesis 504 caribenolide 1 262 Carica papaya danielone 95 lipases 178 carnegine 657 synthesis 387 carolides chloro- 461 carolignans 67 caronaldehydic acid hemiacetal 486 caronolide iv(2) carotane 148-149 9-cis-P-carotene 140 p-carotene 459 synthesis 505 carotenoids biosynthesis 601 Carpesium glossophyllum sesquiterpenes 151 Carpophilus freemani fatty acid biosynthesis 350 Carpophilus hemipterus fatty acid biosynthesis 350 Carthamus tinctorius bisindole alkaloids 422 carveol dihydro- 488 carvol reactions 492 carvone 487,488 Favorskii rearrangement 507 reaction with dichloroketene 494 synthesis 493 carvyl acetate dihydro- 488 caryophyllane 150 caryophyllene synthesis 150 casbene 133 Casearia clarkii,lignans 57 cassane 248 19(4+3)-abeo-~assane iii(6) Cassia grandis quinoline alkaloids 607 Cassia tora brassinosteroids 4 Castanea crenata brassinosteroids 1,4 castanospermine 21,25-26,621-623 synthesis 619 6-epi-castanospermine 623 castanospermine 6-butanoyl- 25 castanospermine 8-butanoyl- synthesis 622 castanospermine 6-deoxy- 622 castanospermine 8-deoxy- synthesis 622 castanospermine 6,7 -diacyl- 26 castanospermine-6-phosphate 25 Castanospermum australe indolizidine alkaloids 621 castasterone 1,3,6,7,8 biosynthesis 6 structure 2 castasterone 6-deoxo- 1,7 structure 2 castasterone 3-epi- 1a-hydroxy- structure 2 castasterone 1P-hydroxy- structure 2 Castelapolyandra,quassinoids 669 Castilleja integra monoterpenoids 507 Castilleja rhexifolia pyridine alkaloids 639 castor bean isopentenyl diphosphate isomerase 597 castor oil hydrogenation 173 catalpol 91 123,507 catalpol 6-deoxy- 508 catechol 5,6-dibromo- 277 catharanthine 578-579 biosynthesis 365 Catharanthus roseus brassinolide biosynthesis 6-7 brassinosteroids 1 2 3,4 HMG-CoA synthases 1 11 monoterpenoid indole alkaloids 559 monoterpenoids 487 terpenoid indole alkaloid biosynthesis 364 cathasterone 2 7 structure 2 Catimbium latilabre rnonoterpenoids 479 Catunaregam nilotica saponins 672 Caulerpa racemosa fatty acids 164 Caulerpa taxifolia metabolites 264 caulerpenyne 264 CC-1065 synthesis 427 ceanothamine-E 80 cebetins 551 cedrane 148- 149 a-cedrene rearrangement 149 cedrol biotransformation 149 8-epi-cedrol biotransformation 149 Cedrus deodara fatty acids 164 cedrusin 3’,4-di-O-methyl- 67 cefoperazone 3 17 celahinine A 639 Celastraceae maytansinoids 440 Celastrus angulatus sesquiterpenes 153 Celastrusflugellaris sesquiterpenes 1 53 Celastrus gemmatus sesquiterpenes 153 Celastrus hindsii pyridine alkaloids 639 sesquiterpenes 153 Celerina hefernani metabolites 294 celeromycalin 294 celhin A 639 cembranes 252-253 a-2,7,1l-cembratrien-4-01, 133 Centaurea aspera sesquiterpenes 15 1 Centaurea malacitana sesquiterpenes 15 1 Centaurea napifolia sesquiterpenes 15 1 Centratherum ritchiei fatty acids 166 centrolobol 87 Centrosema bracteosum triterpenoids 666 Ceonathus americanus c yclopeptide alkaloids 80 Cephaelis ipecactuanha iridoids 5 1 1 cephakicine 400 cephalariasaponin 672 Cephalaria transsylvanica oleanane saponins 672 cephalexin 309 Cephalodiscus gilchristi alkaloids 196 198 pharmacology 201 metabolites 294 cephaloridine 309 cephalosporanic acid 7-amino- acylation 310 cephalosporin 7a-formamido- 3 1 1 cephalosporin 7a-methoxy- 309,3 1 1 cephalosporin C 3 14 biosynthesis 368 cephalosporin C deacetoxy- 3 14 synthesis 21 1 cephalosporinC deacetoxy-3-carbamoyloxy- 3 14 cephalosporin C deacetyl- 314 cephalosporins 309 biosynthesis 321 Cephalosporium acremonium cephalosporin C biosynthesis 368 Cephalosporium aphidicola biotransformation cedrol 149 diterpenoids 251 cephalostatins 197 294 partial synthesis 373 pharmacology 201 synthesis 382 cephalotaxidine iii( 1) cephalotaxine 405 Cephalotaxus harringtonia cephalotaxidine iii( 1) cephamycins 309,3 1 1,322 cepharamine 400 cepharanone B 400 cepharanthine pharmacology 390 cepharasine 400 cephatonine 400 ceramides 28 1 Ceratocapnos heterocarpa cularines 390 Ceratodon purpureus fatty acid biosynthesis 346 ceratopicanol synthesis 150 Cercosporabeticola toxin structure 551 1-8 Natural Products Reports 1997 Cercospora cruenta 5P-cholan-24-oic acid 3a-hydroxy- sesquiterpenes 132 synthesis 380 sesqu iterpenoids 146 SP-cholan-24-oic acid Cercospora spp.polyketides 551 3a77a 12a 19-tetrahydroxy- cereulide 260,455 synthesis 379 Ceropgia juncea pyridone alkaloids 640 cholaphane synthesis 375 cerpegin 640 cholestan-3a-alcohols Mitsunobu acylation cerulenin 375 biosynthesis 346 cholestan-3~-alcohols Mitsunobu acylation fatty acid synthase inhibition 338 375 cerulenin 12-hexanyl- biosynthesis 346 cholestane 3a-hydroxy-4a-allyl- Cespitularia spp. metabolites 283 hypocholesterolemic agent 38 1 Cestrum nocturnum monoterpenoids 479 Sa-cholestane-7a,25-diol synthesis 375 cevadine 200 Sa,22aH,25aH-cholestane-3P,23a-diol, 5a,14a-cevanine-3a-hydroxy-6-one, 198 22,26-epimino-1@,23-epoxy-, 5a,14a-cevanine-3-one-6-O-~-glucoside 198 198 5a,22PH,25aH-cholestane-3P,23a-diol, a-chaconine 202 22,26-epimino- 1 @,23-epoxy- Chaenomeles speciosa monoterpenoids 479 198 Chaerophyllum macrospermum 5a-cholestane-3,6-dione, monoterpenoids 479 22,23-dihydroxy-24-methyl-, 3 Chaetomium cochliodes cholestane glycosides 108 diterpenoids 249 5a-cho1estane-3P75,6P, 15a,26-pentol sesquiterpenes 150 26-sulfate 294 Chainia purpurogena SS-228Y 453 cholestanes partial synthesis 380-383 chain length determining factor 523 SP-cholestan-26-oic acid chalcomoracin biosynthesis 594 3a,7a 12a-trihydroxy- cholic chalcones a-hydroxy- biosynthesis v(2) acid biosynthesis 382 chalcones 2-nitro- reductive cyclisation 605 cholestan-3P-01 fluorination 375 Chamaecyparis formosensis 5a-cholestan-3a-01, diterpenoids 249 22,23-dihydroxy-24-methyl-, 3 sesquiterpenes 15 1 Chamaecytisus austriacus alkaloids 629 5a-c holestan- 3 P-01 22,23-dihydroxy-24-methyl-,3 Chamaecytisus hirsutus alkaloids 34 35 5a-cholestan-6-one, Chamaecytisus proliferus alkaloids 629 22,23-dihydroxy-q,3P-epoxy-Chamaecytisus supinus alkaloids 629 24-methyl- 3 chamaejasmoside 473 5a-cholestan-3-one, chamigrane 148 22,23-dihydroxy-24-methyl-, 3 chasmaconitine 191 5a-cholestan-6-one, chasmanine 191 2a,3a,22,23-tetrahydroxy-chaulmoogric acid dihydro- 165 24-methyl- 1 Cheilolejeunea trifaria sesquiterpenes 147 SP-cholestan-26-oyl CoA cheimoline iii(6) 24-oxo-3a,7a 12a-trihydroxy- Cheirolophus spp.lignans 48 382 cheirotoxin 90 chelerythrine 395,396 5a-cholestan-7a-yl 4-(a-hydroxyphenylmethyl)phenyla physiological effects 396 cetate photolysis 375 chelidonine 395 Chelidonum majus cholest-5-ene 3P 16P-dihydroxy-24-methyl- alkaloids 396 286 24-methylene- 286 physiological effects 396 cholest-4-ene-3P76P-diol benzophenanthridines 395 cholest-4-ene-3,6-dione7NMR 373 berberines 392 cholest-4-en-3-ols methylation 374 chelonanthoside 508 cholest-4-en-3-one fluorination 375 chelonanthoside dihydro- 508 5a-cholest-8( 14)-en- 1s-one 3P-hydroxy- Chelonanthus chelonoides iridoids 508 synthesis 38 1 Chelonaplysilla spp.metabolites 27 6 cholest-4-en-3-one 7a-hydroxy- synthesis chelonin A 275 380 chemical ecology 83-98 cholestenopyrimidines circular dichroism Chenopodium ambrosioides 373 monoterpenoids 117 cholest-5-en-3~-yl4’-vinylbenzoate, crystal chilocorines 634 structure 374 Chilocorus cacti alkaloids 634 cholesterol 250 Chilopartellus spp. mutangin 89 biosynthesis chimanine D 12 iv(6) chimanines 607 15-oxos terols 37 3 chimonanthine 427 cholesterol 24-hydroxy- synthesis 382 Chironia krehsii iridoids 508 cholesterol-baccatin analogues synthesis chironoside 508 381 chivosazoles iv(6) cholesteryl acetate NMR 373 chloranthalactones 153 cholic acid 3P-amino- synthesis 379 Chloranthus juponicus sesquiterpenes 153 Chondrina clienta plant phenolics 84 chloriolin 46 1 Choricarpia leptopetala monoterpenoids a-chlorocodide 401 479 chlorogenic acid 90 Choricarpia subargentea monoterpenoids chlorophyll 592 479 biosynthesis 591 Chorilaena quercifolia coumarins 465 Chlorophyta green 459 466,470 chloroquine 607 chorismate v(3) chokol A synthesis 146 chorismate mutase 366 Subject index chorismic acid biosynthesis 341 436,437 448 Chosenia arbutifolia neolignans 66 oligomenc lignans and neolignans 69 chromenols 279 Chromista secondary metabolites 458 459 Chromobacterium violaceum violacein biosynthesis 364 Chromobacterium viscosum lipases 178 Chromodoris hamiltoni diterpenoids 254 metabolites 288 Chromolaena odorata monoterpenoids 479 chromomoric acid synthesis 169 chromomycinA3 101 chromone 5,7-dihydroxy- 93 Chrozophora obliqua diterpenoids 253 Chrysactinia mexicana monoterpenoids 479 chrysanthemic acid 12 1 synthesis 485 Chrysanthemum cinerariaefolium chrysanthemic acid 121 terpenoids 86 Chrysanthemum indicum monoterpenoids 479 Chrysanthemum parthenium monoterpenoids 498 Chrysanthemum segetum coumarins 465 chrysanthemyl 485486 chrysanthemyl alcohol 12 1 chrysanthemyl diphosphate 12 1 chrysin 93 Chrysocomapaucijlosculosa diterpenes 92 chrysogine 6 13 Chrysomapauciflosculosa sesquiterpenes 147 chrysomelidial 124 biosynthesis 507 chrysomolidial 84 Chrysophaeum taylori hormothamnione 459 Chrysophyceae secondary metabolites 458 Chrysophytes secondary metabolites 458 Chrysothamnus nauseasus terpenoids 86 chuanbeinone 198 chymotrypsin mechanism vi(4) cibaric acid 166 cichoriin determination 465 Cichorium intybus sesquiterpenes 15 1 ciguatoxin 296,457 ciliates secondary metabolites 457-458 Ciliophora secondary metabolites 457-458 cimicidanol 663 cimicidanol3-O-a-~-arabinoside, 663 cimicidol3-O-a-~-xyloside, 663 cimicifol 3-O-P-~-xyloside 663 Cimicifuga foetida triterpenoids 663 Cimicifuga simplex triterpenoids 663 cimicifugosides 663 cimicinol 3-O-P-~-xyloside 663 cimigenol 663 cimigenol3-O-P-~-glucoside, 663 cimigenol3-O-P-~-xyloside,25-anhydro- 663 cimiside F 663 Cinachyrella spp.fatty acids 164 steroid oximes iii(3) Cinchona alkaloids 581-584 lanthanoid salts 58 1 Cinchona robusta anthraquinones 60 1 isopentenyl diphosphate isomerase 597 cinchonidine lanthanoid salts 58 1 cineol 486,488 1,8-cineole 91 120 1,8-cineole synthase 1 17 cineverine 35 cinnamalde h yde 9 1 cinnamaldehyde p-hydroxy- 96 cinnamamide 90 cinnamic acid bis(methy1enedioxy)- 45 cinnamic acid hydroxy- 90 Cinnamomum albiforum monoterpenoids 479 Cinnamomum cambodianum monoterpenoids 479 Cinnamomum camphoru monoterpenoids 479 Cinnamomum sulphuratum monoterpenoids 479 Cinnamomum tamala monoterpenoids 479 Cinnamonumphilippinense,lignans 46 cinnamophilin 46 circinamide iv(4) cirensosides 669 Cissampelos pareira azafluoranthenes 400 Cissampelos sympodialis morphine alkaloids 400 Cistanche deserticola iridoids 508 Cistus populifolius diterpenoids 246 citbismine-A 18,615 citbismines 6 15 citpressine-11 18 citpressines 615 citracridone-I dihydroxy- 18 citracridone-11.6 14 citracridones 615 citramine 615 citrate synthase crystal structure v(6) citreoazopyrone iv(4) Citrofortunella mitis isopentenyl diphosphate transport 600 Citronella gongonia iridoids 508 citronellal 484 citronellol 482,483 metabolism 482 synthesis 483 citronellyl acetate 483 citropone-C 615 citrusamine 6 15 Citrus aurantium monoterpenoids 479 Citrus grandis acridone alkaloids 615,616 Citrus hassaku coumarins 466,473 citrusinines 615 Citrus limonia crenulatin 467 Citrus macroptera quinoline alkaloids 11 Citrus paradisi acridone alkaloids 18,6 I5 monoterpenoids 479 Citrus sinensis isopentenyl diphosphate isomerase 597 monoterpenoids 117,479,487 sesquiterpenes 132 Citrus unshiu brassinosteroids 4 monoterpenoids 116,486 Cladiella krempfi metabolites 286 Cladiella spp.metabolites 285 Cladobotryum varium quinazoline alkaloids 16 Cladocroce incurvata fatty acids 164 Cladophora vagabunda monoterpenoids 494 Clarkia breweri isopentenyl diphosphate isomerase 597 linalool biosynthesis 115 monoterpenoids 482 Clathria hasilana alkaloids 633 clathyrimine A 633 clathyrimine B 633 claudimerins 473 clausarinol 469 Clausena anisata indole alkaloids 413 Clausena excavata monoterpenoids 479 Clausena lansium indole alkaloids 413 clausenine structure 413 clausenol structure 413 clavalanine clavam biosynthesis 329 1-10 Natural Products Reports 2997 clavam-2-carboxylate clavam biosynthesis 329 clavaminate synthase 330 clavaminic acid 3 12 biosynthesis 321 330 clavaminic acid synthetase clavulanic acid biosynthesis 322 clavams biosynthesis 309-333 329-330 367 clavamycins 3 13 biosynthesis 330 Clavelina cylindrica metabolites 290 Clavelina lepadiformis metabolites 290,294 quinoline alkaloids 607 Clavelina picta alkaloids 633 metabolites 290 clavem 315 clavepictines 633 Claviceps purpurea ergot alkaloid biosynthesis 364 isopentenyl diphosphate isomerase 595 claviminate synthase 367 claviminic acid biosynthesis 366 clavizepine synthesis 391 clavulactones 281 clavulanic acid amides 314 biosynthesis 309-333 320-329,366-367 chemistry 314-317 derivatives 3 14-3 15 development 309-3 12 clavulanic acid dihydro- esters 3 14 clavulanic acid discovery 309-3 12 esterification 3 14 mode of action 3 18-3 19 structure 3 11 structure-activity relationships 3 16-3 17 synthesis 315-316 synthetic analogues 317-318 clavulanic acid 9-aminodeoxy- 3 17 clavulanic acid 9-deoxy- 3 14 sodium salt 317 Clavularia viridis metabolites 28 1 286 clavularin A synthesis 156 cleistanthanes 248 Cleistocalyx fullageri monoterpenoids 479 Cleistocalyx operculatus monoterpenoids 479 clematichinenol 470 clematichinensosides 672 Clematis chinensis coumarins 466,470 oleanane saponins 672 Clematis montana oleanane saponins 672 clematosides 672 clemontanosideE 672 cleomblynols 666 Cleome amblyocarpa triterpenoids 665 cleroda-4( 18) 13-diene- 15-oic acid 246 clerodanes 90,246-247 Clerodendrum indicum cleroindicin A iv(6) Clerodendrum inerme iridoids 508 clero-3,13( 14)-dien- 15-oic acid 246 cleroinidicinA iv(6) clerosterols 264 clinopodisides 67 1 Clinopodium chinensis oleanane triterpenoids 67 1 clionasterol synthesis 382 Clione antarctica metabolites 288 Clitoria ternatea plant defensins 93 clonidine analgesic effects 403 Clostridium butyricum fatty acid biosynthesis 341 cloxacillin 309 3 1 1 Clusia plukenetii plukenetione iii( 1) CNB-253 108 Cnicus benedictus sesquiterpenes 15 1 cnidaria amino acids iv(3) cocaine biosynthesis 359 cocaine meta-hydroxy- synthesis 648 coccinellid beetles alkaloids 634 Coccinia indica lupane triterpenoids 669 Cocculus hirsutus jamtinine 405 Cocculus trilobus morphine alkaloids 400 Cochliobolus spicifer cochliospicin A iii(5) polyketides 549 cochliospicinA iii(5) coclaurine 389 biosynthesis 362 coclaurine methyl- biosynthesis 363 coclaurine N-methyl- 389 biosynthesis 361 codeine biosynthesis 362 pharmacology 404 codeine dihydro- pharmacology 404 codeine:NADP oxidoreductase 362 codeinone biosynthesis 362 codeinone 7,7-diphenyldihydro- 402 codeinone 7-phenyldihydro- 402 Codium arabicum metabolites 264 coelenterates metabolites 281-286 colchiceine 404 colchicine 404 biosynthesis 363 colchicine 4-acetyl- 404 colchicine 4-formyl- 404 colchicine methyl- biosynthesis 363 colchicine thio- NMR 404 colchicoside thio- radioimmuno-assay 404 Colchicum ritchii colchicine 404 phenethylisoquinolines 404 Colchicum speciosum colchicine 404 Colchicum variegatum colchicine biosynthesis 363 coleon A 249 Coleus igniarius diterpenoids 249 Colletotrichum gloesporioides danielone 95 Colletotrichum musae phytoalexins 95 collinin epoxy- 470 collinusin 59 Collybia confluens sesquiterpenes 150 collybial 150 colneleic acid 174 synthesis 168 Colocasia antiquorum fatty acids 165 columbamine 392 columbamine tetrahydro- conversion into canadine 363 columbianetin 95 columbianetin 3-( 1’,1’-dimethylally1)- 468 columbianetin-p-D-glucoside 467 columbidine 192 Comhretum rotundifolium triterpenoids 666 comosivine 404,405 compactinervine 568 compound2 76 1,4-conadiene N-(N’-methylacetamid0)-3-0~0- 198 1,4,17(20)-conatriene 1 1a-acetoxy-N-demethyl-3-oxo- 198 concanomycin biosynthesis 535 condelphine 193 condyfoline synthesis 570 Condylactis gigantea metabolites 28 1 condylocarpine 14aH-hydroxy- 568 condylocarpine 14P-hydroxy- 568 confusameline 14,609 congorosin A iv(3) conidendrin 57 coniine 641 conocephalenol 158 Conophthorus resinosae pityol 85 consitutive antimicrobial defence 93 Consolida amhigua alkaloids 192 constanolactones 266 Constantinea simplex fatty acid biosynthesis 344 fatty acids 164 metabolites 266 convolutamydines 286 Conyza linearis diterpenoids 245 copalyl diphosphate 136 copalyl pyrophosphate ent-kaur- 16-ene biosynthesis 222 coptisine 392 coptisine dihydro- 393 coptisine 8-oxodihydro- 392 Coptis japonica neolignans 66 Corallina granfera fatty acids 164 Corallina mediterranea metabolites 266 cordifoliside D 247 cordioside 247 coriolic acid 15,16-didehydro- synthesis 168 coriolic acid synthesis 168 coriolin synthesis 494 corlumidine 394 cornigerin 404 cornigerine 3-O-demethyl- 404 Corollospora pulchella melinacidins 460 coronaridine 578 coronatine biosynthesis 21 1 Coronilla spp.coumarins 465 cortical steroids fluorinated NMR 373 corticosterone 1 1-deoxy- conversion into aldosterone 379 cortisol tetrahydro- crystal structure 373 Corydalis decumhens benzophenanthridines 396 phthalide-isoquinolines 394 protopines 393 secoberberines. 393 Coryda1is ma rchallia na ,aporp hines 397 corydamine 393,405 corydine 397 corydine chloride N-methyl- 397 corydine N-oxide 397 Corylus avellana fatty acids 165 Coryanthe alkaloids synthesis 560 corynantheidol 10-methoxy- synthesis 564 corynantheine.559-565 synthesis 560 corynantheol 1 0-methoxydihydro- synthesis 564 Corynascus setosus setosusin iv(2) Corynehacteriurn diphtheriae fatty acid biosynthesis 339 341 Corynehacteriurn sepedonicum fatty acids 164 Corynehacterium spp. fatty acid biosynthesis 340 corynemycolic acid biosynthesis 34 1 corypalline 387 corypalmine chloride N-methyl- 392 corysamine iodide N-methyl- crystal structure 392 corytuberine 397 cosalane synthesis 380 cossonidine 193 costaricine 390 Costridium hutyricxm fatty acid biosynthesis 338 costunolide IS1 costunolide dehydro- 15 1 Cotesia glomeruta induced chemical defence 89 Cotesia ruhesiula induced chemical defence 89 Cotinus coggygriu monoterpenoids 480 cottonseed oil hydrogenation 173 cotylenol 254 coumarin 7-acetoxy-5,6-dimethoxy- 466 47 1 coumarin 3-acyl-4-hydroxy- 472 coumarin 6-acyl-7-methoxy- 466 4-substituted synthesis 468 coumarin 7-( P-tert-alky1aminoalkoxy)-8-benzoyl-4-methyl- synthesis 47 3 coumarin alkyl-7-oxy- spectroscopy 465 coumarin 6-allyl-7-hydroxy- 466 coumarin 3-arylsulfonyl-4-hydroxy- psychopharmacological study 472 coumarin 3-chloro- synthesis 473 coumarin 3-cinnamoyl- 4-substituted 472 coumarin diazo- synthesis 473 coumarin 6,7-dihydroxy- synthesis 470 coumarin 7,8-dihydroxy- 472 coumarin 6,8-dihydroxy-5,7-dimethoxy- 47 1 coumarin 6,8-dihydroxy-7-methoxy- 466 47 I coumarin 7-(2,3-dihydroxy-3-methylbutyl-oxy)-5-hydroxy-6-methoxy-, 47 1 coumarin 5,8-dimethoxy- 466,472 coumarin 7-ethoxy-4-( 1-piperazinyl)- 473 coumarin geranyl- 469 coumarin 7-geranyloxy- 465 coumarin 7-hydroxy- 472 coumarin 3-hydroxy-6,7-dimethoxy- synthesis 470 coumarin 7-methoxy-8-hydroxy- 465 coumarin 4-methyl- 472 coumarin 5-methyl- 470 coumarin 5-methyl-7-hydroxy- 472 coumarin 4-phenoxy- synthesis 472 coumarin 4-phenyl- synthesis 470 coumarin 3-phenyl-6-methylstyril- 4- sub st it uted synthesis 472 coumarin 4-( 1-piperaziny1)- synthesis 473 coumarin 7-(3-piperidinopropoxy)-8-benzoyl-4-methyl- 473 coumarin 4-propyl- synthesis 470 coumarin 5,6,7,8-tetramethoxy- 47 1 coumarin 6,7,8-trihydroxy- 466,471 coumarin 5,6,7-trimethoxy- 465 coumarins 465475 5 ,7-dioxygenated 468470 6,7-dioxygenated 470 7,8-dioxygenated 470 disubstituted 7-oxygenated 468 identification 465 isopentenyl diphosphate isomerase 598 4-oxygenated 472 7-oxygenated 465 separation 465 C-substituted 7-oxygenated 466-467 5,6,7,8-tetraoxygenated,47 1 5,6,7-trioxygenated 47 1 5,7,8-trioxygenated 47 1 6,7,8-trioxygenated 47 1 coumarin-6-su1fono-N-amino acids synthesis 473 coumarrayin crystal structure 468 coumesetans 472 ent-CPP synthase 223 CPT-1 1 586 crambescidin 800 294 crassicaudine 192 crassicaudine 14-O-debenzoy1-84-deacetyl- 192 Cratoxylum cochinchineses hybrid lignans 70 Creatonotos transiens pyrrolizidine alkaloids 83 crellisin A 54 Cremanthodium ellisii lignans 54 crenatine-A 77 crenulatin 467 crenulide acetoxy- 265 m-cresol 85 p-cresol 85,91 criamides 270,416 Crihrochalina olemda bisindole alkaloids 424 metabolites 274 Cribrochalina spp.metabolites 274 Cribrochalina vasculum fatty acids 164 metabolites 270 cribrostatins 274 crinamidine 304 crinamine 304,305 crinane 3P 11 a-dihydroxy- 1,2-dehydro- 304,307 crinane 8-hydroxy-9-methoxy- 304,307 crinane 3P-methoxy-6a,11 P-dihydroxy- 1,2- dehydro- 304,307 crinasiadine N-methyl- 304 306 crinine 304,305 307 Crinum kirkii alkaloids 305 criocerine 577 Cristaria plicata metabolites 259 Crithidia fasciculata fatty acid biosynthesis 343 Crithmum maritunum monoterpenoids 480 crobarbatic acid synthesis 655 crooksidine 573 synthesis 575 crooksiine 580 Croton chilensis diterpenoids 246 crotonic acid 246 Croton matourensis diterpenoids 246 Crypthecodinium cohnii docosahexaenoic acid 456 Cryptococcus neoformans indole alkaloids 413 cryptolepine 4 I4 cryptolepine hydro- 414 Cryptolepis sanguinolenta bisindole alkaloids 423 indole alkaloids 414 Cryptomeria japonica sesquiterpenes 15 1 152 Cryptophyceae secondary metabolites 459 Cryptophyta secondary metabolites 459 cryptopleurine 3 1 synthesis 627 cryptopleurine 0x0- 3 I cryptoporic acid 131 cryptostyline-11 388 cryptotanshinone iv(4) cuauhtemone synthesis 153 cubenene 128 biosynthesis 149 v(5) cubenene synthase v(5) cubenol 4P,Sa-dihydroxy- 264 cubenol 4q,5a-dihydroxy- structure 149 cuben-3-one 264 cubensic acid 165 Cucumis sativus brassinosteroids 5 fatty acids 165 cucurbitac ins pharmacology 664 Cucurhita maxima brassinosteroids 5 diterpenoids 136 138 gibberellin biosynthesis 222 226 Cucurhita pepo monoterpenoids 487 cularidine 390 cularine dehydro- synthesis 39 1 cularine dioxo- synthesis 391 cularine hydroxy- 390 cularines 390-39 1 physiological effects 391 cumingianoside A 666 Cunila spicata monoterpenoids 505 Subject index 1-11 Cunninghamella elegans arteether 149 Cunninghamella spp.diterpenoids 249 cuparene 128 Cuphea lanceolata fatty acid biosynthesis 347 KAS III 347 Cupressus arizonica brassinosteroids 3 4 Cupressus hakeri sesquiterpenes 148 149 Cupressus macnahiana sesquiterpenes 149 Cupressus semprrvirens monoterpenoids 480 tropolone glucosides 95 curacin A 454 curacins 262 curcudiol 147 28 1 curcuhydroquinone-1-monoacetate 147 28 1 curculigine 70 Curculigo recurvata norlignans 70 a-curcumene 128 curcuphenol 147,281 curine 0,O-dimethyl- 390 Curtohacterium pusillum cyclohexyl fatty acid biosynthesis 437 cuscohygrine biosynthesis 359 Cuscuta chilensis alkaloids 629 Cuscuta chinensis lignans 54 Cuscuta reJlexa alkaloids 630 cutin biosynthesis 346 Cutleria multifda metabolites 264 Cyanchum hancockianum monoterpenoids 486 cyanobacteria fatty acid biosynthesis 336 secondary metabolites 454 cyanogenic glycosides biosynthesis 366 Cyathia leppifera triterpenoids 675 Cyathocalyx zeylanica diterpenoids 246 Cyhastela spp.tryptamines 416 cyclase I 120 cyclase 11 120 cyclase 111 120 c ycloalpigenins 663 cycloalpiosides 663 cycloartanes 663 cycloartan-24-one 3P,28-dihydroxy- 663 cycloart-24-ene-3P 16P,2 l-triol 663 c ycloartenol 663 cyclobrassinin biosynthesis 365 cyclobrassinone 93 cyclobutane- 1,3-diimine 2,2,4,4-tetramethyl-N,N-bis(2,6- dimethylpheny1)- 89 cyclocarioside I 666 cyclocariosides 665 Cyclocarya paliurus triterpenoids 665,666 cyclocitral synthesis 506 P-cyclocitral 9 1 4,9-cyclodauc-7-en- 14-01 iii(6) cyclodidemnamide 290 Cyclodiscus gahunensis diterpenoids 248 9,15-cyclo-GA biosynthesis 226 23 1 240 12,16-cyclo-GA4 biosynthesis 236 P-cyclogeraniol reactions 506 cyclogeranylketene reactions 506 cyclogeranyl sulfone reactions 506 cyclogeranyl tosylate reactions 506 c yc loheptane bios yn thesi s 433-440 cycloheptanecarboxylic acid biosynthesis 438 cyclohexa-I ,5-dienecarboxylicacid dihydroxy- biosynthesis 341 cyclohexa- 1,5-dienecarboxyIic acid 3,4-dihydroxy- 536 cyclohexane biosynthesis 433-440 cyclohexanecarbonyl CoA fatty acid biosynthesis 341 cyclohexanecarboxylic acid biosynthesis 433,536 cyclohexanecarboxylic acid 3,4-dihydroxy- 536 biosynthesis 436 cyclohexane- 1,3-dione biosynthesis 345 cyclohex-2-enecarbonyl CoA fatty acid biosynthesis 341 cyclohex-1-enecarboxylic acid 435 cyclohex-1-enecarboxylic acid 4,5-dihydroxy- 536 cyclohex-1-enylcarbonyl CoA reductase 436 cyclohex-2-enylcarbonyl CoA isomerization 436 cyclohexylcarbonyl CoA biosynthesis 436 o-cyclohexylundecanoic acid 434 cyclo-[4-methylprolinenorvaline],270 cyclomyltaylan-5a-ol 158 cyclopamine 202 cyclopentadiene menthyltetraphenyl- 489 cyclopentadiene neomenthyltetraphenyl- 489 cyclopenta[h]quinolizidinealkaloids 30 cyclopent-2-enone 4-methyl- synthesis 502 cyclopeptide alkaloids 75-82 antibacterial activity 79 antifungal activity 79-80 biological activity 79-80 biosynthesis 80-8 1 classification 75-77 sedative activity 79 structures 77 synthesis 79 tissue culture 80-8 1 cyclopinolenic acid synthesis 169 cyclopropane fatty acids synthesis 169 cyclopropene fatty acids synthesis I69 cyclorenierin A 145 cyclorenierins 279 cyclosantanal 148 cyclosiphonodictyol A bis(sulfato)- 147 27 8 Cyclotella cryptica fatty acid biosynthesis 344 cyclotheonamides 270 Cyclotrichium niveum monoterpenoids 480 Cydia pomonella pheromones 86 Cylasformicarius cadina-4,1O( 15)-dien-3-one 90 sesquiterpenes 149 cylindricines 290 cylindrocarine 12-demethoxy-N-acetyl- synthesis 576 Cylindrocarpon lucidum sesquiterpenes 145 cylindrol A 145 Cymhastela coralliophila metabolites 28 1 Cymhastela hooperi kelsoene iii(5) Cymhastela spp.metabolites 270 279 Cymhopogonflexuosus monoterpenoids 480 Cymhopogonjwarancusa monoterpenoids 480 Cymhopogon schoenanthus monoterpenoids 480 Cymhopogon spp. monoterpenoids 482 Cynanchum taiwanianum cynandiones iv(3) Cynanchum vincetoxicum phenanthroindolizidine alkaloids 31 cynandiones structures iv(3) Cynoglossum creticum pyrrolizidine alkaloids 657 Cynoglossum officinale alkaloids 87 pyrrolizidine alkaloid biosynthesis 361 pyrrolizidine alkaloids 658 cyperene iii(5) a-cyperone synthesis 494 Cyperus alopecuroides cyprotene iii(5) Cyperus iria fatty acids 166 Cyperus rotundus sesquiterpenes 149 cyprotene iii(5) cyproterone acetate supercritical fluid chromatography 374 cystathionine y-synthase amino acid synthesis 206 cysteamine S-(dec-3-ynoyl)-N-acetyl-,338 cysteine isotope-labelled synthesis 21 2-2 14 cysteine proteases inhibition vi(3) Cystoseiraceae diterpenoids 245 Cystoseira crinata diterpenoids 245 metabolites 265 Cystoseira mediterranea metabolites 265 cytisine 33 35 630 cytisine N-acetyl- 629 630 cytisine 1 1 -allyl- 629 cytisine N-formyl- 629 630 cytisine N-methyl- 34 35,629 cytisine sparteine 1Oa-hydroxymethyl- 34 cytisine- 12-acetic acid synthesis 37 cytisine alkaloids 32-37 628-633 analysis 628 chemical ecology 628-630 chemotaxonomy 628-630 detection 628,629 isolation 629 occurrence 628 spectroscopy 630-63 1 structures 630-63 1 synthesis 63 1 Cytisuspraecox alkaloids 34 35 cytochrorne P450cam complexation with putidaredoxin vi(6) cytogenin biosynthesis 533 cytokinins analysis 146 isopentenyl diphosphate isomerase 598 Cytophaga spp.fatty acid biosynthesis 336 Dactylanthus taylorii squalene 9 1 dactyline 394 399 Dactylocapnos torulosa berberines 392 394 dimeric aporphines 399 dactylol 287 synthesis 15 1 dactylomelynes 287 dactyloxene-B 287 dactyloxene-C 287 dactyloxenes synthesis 146 daechucyclopeptide-I 76 daechuine-S3 77 daechuine-S5 77 daechuine-S6 76 daechuine-S7 76 daechuine-S8-1 77 daechuine-S 10 75,76 daffodil isopentenyl diphosphate isomerase 597 Dahlia merckii plant defensins 93 DAHP synthase 444 daidzein 88 a-damascone synthesis 506 damirone A synthesis 419 damirone C 274 dammara-20,24-dien-28-oic acid 3P 16a-dihydroxy- 666 dammara-20,23-dien-3P-o1 25-hydroperoxy- 666 dammarane-3P 12P,20,24,25,28-hexoI 666 dammarane-3P 1 2P,20,24,25-pen t01 666 dammarane-3P,20,24,25-tetrol 666 dammarane triterpenoids 665-669 dammarenedio 11 666 dammar-22-ene-3P 12P,20,25-tetrol 666 dammar-23-ene-3P,20,25,26-tetrol 666 dammar-25-ene-3P,20,2 1,24-tetrol 666 danaidal 7-hydroxy- 83 Danaliella acidophila fatty acids 165 Danaus plexippus 1-12 Natural Products Reports 1997 flavonoids 90 delphisine N-oxide NMR 195 oviposition stimulants 91 delsemines 194 danielone 95 deltaline N-oxide NMR 195 danshenols iv(4) deltamethrin synthesis 486 Daphne mezereum linalool 91 delvaines 194 Daphniphyllum alkaloids synthesis iii(2) demecolcine 2-O-demethyl- 404 ent-darling ine 648 dendiculatin A 553 Datura candida tropane alkaloids 91 Dendrilla cactos metabolites 274 Datura innoxia scopolamine biosynthesis Dendrilla membranosa 359 diterpenoids 254 Datura stramonium metabolites 279 tigloyl-CoA seudotropine acyl transferase dendrillin 254,279 360 Dendrobatespumilio alkaloid 223A iii( 3) tropic acid biosynthesis 359 Dendrobeania murrayana metabolites 286 Datura wrightii tropane alkaloids 84 Dendrodoa grossularia Datylocapnos torulosa isoquinoline alboinin iii(3) alkaloids 387 metabolites 290 Daucus carota polyketides 55 1 dendrolasin 279 daunomycin 99 dendrolosin 91 DNA complex 100 Dendryphiella salina dendryphiellins 460 daunorubicin biosynthesis 53 1 dendryphiellins 460 daunorubicin 2 ’-p-fluoro- 10 1 denudatine 192 daunorubicine 405 2-deoxy sugars 101 dauricine pharmacology 390 6-deoxyerythronolide B synthase v(2) daurisoline 390 8-epi-deoxyloganic acid 122 deacetoxycephalosporin C synthase deplancheine synthesis 560 clavulanic acid biosynthesis 321 Deppea blumenaviensis monoterpenoid deacetoxycephalosporin synthase 368 indole alkaloids 559 deca-2,4-dienoic acid 5-hydroxy- deppeaninol 559 biosynthesis 346 depsides 83 decanoic acid biosynthesis 347 depsidones 83 decanoic acid 4-hydroxy- 179 Dermocybe cardinalis cardinalins iv(4) decanoic acid lo-(2-propylcyclopentyl)- Derris scandens coumarins 466 472 methyl ester synthesis 169 desaturase Synechocystis spp.339 decanoic acid 2,4,6,8-tetramethyl- desertomycin A biosynthesis 536 biosynthesis 353 desertomycin B biosynthesis 536 y-decanolactone 179 desertomycins 536 decanoyl ACP fatty acid biosynthesis 347 Desmapsama anchorata fatty acids 164 decares tric tines 548 desmarestene 264 350 Desmarestia aculeata metabolites 264 deca-2,4,6,8-tetraene-3,5,7-trimethyl- deca-3,5,7-triene 6-ethyl-4-methyl- Desmarestiafirma metabolites 264 biosynthesis 350 Desmia hornemanni metabolites 262 4-decenoic acid 3-methyl-8-hydroxy- Desmos cochinchinensis fatty acids 164 methyl ester 164 Desmos longifolia dec-2-enoyl ACP thioesters fatty acid aporphines 397 biosynthesis 338 oxoaporphines 399 dec-3-enoyl ACP 336 Detarium microcarpum dec-3-enoyl ACP thioesters fatty acid diterpenoids 246 biosynthesis 338 termite antifeedant activity 90 decorticasine 658 dethiabiotin biosynthesis 354 decumbenine B 396 deuterom ycetes decumbenine C 394 marine secondary metabolites 46M 1 decursin 465,467 terrestrial secondary metabolites 461 dehydrogenases amino acid synthesis 206 dextromethorphan analgesic effects 403 delaminomycin A biosynthesis 543 DHQ synthase 444 delaminomycin B 544 dhurrin biosynthesis 366 delaminomycin C 544 diabolic acid 164 delavinone 198 biosynthesis 177 delcosine 14-dehydro- 193 diaboline 12-hydroxy- 1 1 -methoxy- 568 delectinine 193 Diabrotica virgifera terpenoids 86 delelatine 193 diacholestanes structure 383 Deliseafimbriata metabolites 266 Diaphania nitidalis monoterpenoids 487 Delisea pulchra metabolites 266 diarctigenin 69 delnuttaline 193 194 diarrhetic shellfish poisoning toxins v( 1) delnuttidine 193 Diatomae secondary metabolites 458459 delnuttine 193 diatoms secondary metabolites 458459 delpheline 193 5-diazobenzo[b]fluorenes,biosynthesis 370 delphinine N-oxide NMR 195 dibenz[dfiazonine alkaloids biosynthesis Delphinium ajacis alkaloids 192 362 Delphinium albiflorum alkaloids 192-193 dibenzocyclooctene 60-62 Delphinium andersonii alkaloids 193 dibenzocyclooctene tetrahydro- 47 Delphinium cardiopetalum alkaloids 193 dibenzofurans 94 Delphinium cossonianum alkaloids 193 Dicentra spectabilis benzylisoquinoline Delphinium elatum alkaloids 193 alkaloid biosynthesis 36 1 Delphinium munzianum alkaloids 193 dicentrine 397 Delphinium nuttallianum alkaloids pharmacology 399 193-194,194 dichapetalin A 666 Delphiniumperegrinum alkaloids 194 Dichapetalum madagascariense Delphiniumpotaninii alkaloids 194 triterpenoids 666 Delphinium spp.diterpenoid alkaloids 19 1 Dichapetalum toxicarium fatty acids 172 Subject index diconiferyl alcohol dehydro- 45,66 Dicranolejeunea yoshinagana sesquiterpenes 158 dictamnine 11,606 609 Dictamnus dasycarpus quinoline alkaloids 11 Dictoya dichotoma monoterpenoids 487 Dictyodendrilla spp.metabolites 279 sesquiterpenes 145 dictyodendrillins 145 27 9 Dictyolomaperuviana quinoline alkaloids 605,606 dictyolomides 605,606 Dictyonella incisa metabolites 28 1 Dictyopteris delicatula metabolites 265 sesquiterpenes 149 Dictyopteris divaricata metabolites 265 a-dictyopterol synthesis 153 265 Dictyosphaeria sericea dictyosphaerin iii(2) dictyosphaerin iii(2) Dictyota crenulata metabolites 265 Dictyota dichotoma metabolites 265 didemnaketals 290 didemnenones 290 didemnimides iii(4) didemnin N 290 didemnins 290 didemnolines 290,415 Didemnum conchyliatum didemnimides iii(4) Didemnum molle metabolites 290 Didemnum rodriquesi metabolites 290 Didemnum spp.bisindole alkaloids 42 1 metabolites 290 tryptamines 41 5 Didemnum voeltzkowi metabolites 290 dienes dihydroxylation 583 1,6-diepicastanospermine125 6,8a-diepicastanospermine,25 8,8a-diepicastanospermine,1 -deoxy- 25 2,3 -diepicastasterone structure 2 3,24-diepicastasterone structure 2 2,3-diepidolichosterone,25-methyl- structure 3 1,2-diepilentiginosine 22 1,8a-diepislaframine 22 8,8a-diepiswainsonine 23 diferulic acid dehydro- ethyl ester 46 differolide 526 digitalis partial synthesis 380 digitoxigenin synthesis 380 digitoxigenin 3-glucoside 90 diglycerol tetraether dibiphytanyl- biosynthesis 343 dihomo-y-linolenic acid 178 dihydrodipicolinate reductase vii(4) dihydrodipicolinate synthase v(2) dihydrofolate reductase active site residues v(6) dih ydrox ylation alkenes 582 dienes 583 diisocyanoadociane 279 Dilleniapapuana oleanane triterpenoids 669 dillenic acid D 669 dillenic acid E 669 dimethylallyl diphosphate biosynthesis 112,591 in situ production 598 metabolic pools 599-600 transport 598,600 dimethyl disulfide 91 dimethyl sulfide 86,91 dimethyl trisulfide 91 dimorphecolic acid synthesis 168 Dimorphothecapluvialis fatty acids 165 1-13 Dinoflagellatea secondary metabolites 455-457 Dinophysis acuminata polyketides 544 Dinophysis fortii polyketides 544 Dinophysis spp.,okadaic acid 456 dinophysistoxin-1 14,15-dihydro- 270 dinophysistoxins 544 29,30-dinoroleanane- 13p 15p 16p,26-tetrol 67 1 Dinozoa secondary metabolites 455457 diolmycin A2 synthesis 414 dioncophylline C synthesis 388 Diospyros kakis coumarins 466,473 3,7-dioxabicyclo[ 3.3 .O]octane 2,6-diaryl- 54-56 dioxinoacrimarine-A 18 diphyllin 44 diplaziosides 675 Diplazium subsinuatum triterpenoids 675 Diplodiapinea tropolone glucosides 95 Diplolophium africanum monoterpenoids 480 Diplolophium buchananii coumarins 466,467 monoterpenoids 498 diplophy llin 153 dipocolinic acid 4-hydroxy-2,3,4,5-tetrahydro- v(2) diprenorphine pharmacology 403 Dipsacus japonicus oleanane saponins 672 Discariafebrifuga cyclopeptide alkaloids 80 Discaria longispina cyclopeptide alkaloids 80 discarine-C 78 discarine-D 77 78 discarine-E 77 discarine-F 77 discarine-G 78 discarine-H 78 discarine-K 78 discarine-L 78 discarine-X 77 Discodermia dissoluta metabolites 270 discodermolide 270 discorhabdin G 274 discorhabdins biosynthesis 371 discretamine 397 disorazoleAI,biosynthesis 524 dissectolideA 253,283 Distemonanthus benthamianus hybrid lignans 70 Disrylium racemosum brassinosteroids 3,4 diterpenes kaurenoid biotransformations 25 1 diterpenoids 133-140 245-258 bicyclic 245-247 macrocyclic 251-253 tetracyclic 250-25 1 tricyclic 247-250 2,4-dithiapentane 9 1 docetaxel 252 docosaheptaenoic acid 263 docosahexaenoic acid 456 dodeca-3,5-dienoic acid 7-hydroxy- biosynthesis 346 dodecanoic acid biosynthesis 336 dodecanoic acid epoxy- 179 dodec-7-en-1-yl acetate 85 86 doisynolic acid crystal structure 373 dolabelides 287 Dolabella auricularia metabolites 287 dolabellane 253 265 dolabellin 287 dolabrane 248 Dolabrifera dolabrifera dolabriferol iv( 1) dolabriferol iv( 1) dolastatin E 287 dolichantoside 559 1-14 Natural Products Reports 2997 dolicholide structure 2 Dolichos lablab brassinosteroids 4 oleanane triterpenoids 67 1 dolichosterone structure 3 dolichosterone 6-deoxo- structure 3 dolichosterone 2-deoxy-25-methyl- structure 3 dolichosterone 6-deoxy-25-methyl- structure 3 dolichosterone 23-0-P-~-glucopyranosyl-2-epi-25-methyl- 1 dolichosterone,23-0-~-~-glucopyranosyl-25-methyl- 1 8 dolichosterone,23-0-glucosyl-25-methyl- structure 3 dolichosterone 25-methyl- structure 3 domoic acid 458459 dopa decarboxylases decarboxylases 361 Doryphora sassafras monoterpenoids 480 downeyosides 294 doxorubicin 101 Dracaena reflexa monoterpenoids 480 dracunculifoliol synthesis 153 Drechslera avenue sesquiterpenes 153 dregamine 565 drimadiene synthesis 147 drimane sesquiterpenoids synthesis 494 drim-8( 12)-ene I47 Drosophila buzzatii fatty acid biosynthesis 349 Drummondita spp.sesquiterpenes 157 DTX-4 263 DTX-Sa 263 DTX-Sb 263 Ducrosia ismaelis cournarins 466,469 Dumasia truncata saponins 672 Dunaliella spp. @carotene 459 duocarmycin A synthesis 426,427 duocarmycin SA synthesis 426 duprezianane 148-149 149 durbinals 279 dynemicin 542 dynemicin A 541 dyshomoerythrine 404 dysidazirine 270 Dysidea arenaria metabolites 270,278 279 sesquiterpenoids 146 Dysidea etheria dysidiolide iii( 1) D ysidea frag i 1is fatty acids 164 metabolites 270 Dysidea herbacea dysiherbaine iii(5) metabolites 270 279 Dysidea incrustans metabolites 28 1 Dysidea spp.metabolites 277 Dysidea tupha metabolites 279 dysidiolide iii( I) dysiherbaine iii(5) Dysoxylum cumingianum triterpenoids 666 Dysoxylum spectabile 2-norbornanol 89 E eburnamenine 2 1 -epidihydro- synthesis 578 eburnamine 577 eburnamine 19-oxo- 577 eburnamonine 577 eburnamonine desethyl- synthesis 578 ecdysone 25-deoxy- synthesis 382 ecdysone 20-hydroxy- 89 acetylation 382 biosynthesis iv(4) ecdysone 20P-hydroxy- 373 ecdysone 22-acetate 20-hydroxy- 89 ecdysteroids 89 tandem mass spectrometry 373 ecdysterone dehydro- 286 ecgonine meta-hydroxybenzoy 1- synthesis 648 echihumiline 657 echinatine 83 658 echinatine 3’-acetyl- 657 echinatine 12-0-acetyl- 658 echinoderms metabolites 294 Echinophora tenuifolia monoterpenoids 480 Echium humile pyrrolizidine alkaloids 657 Ecteinascidia turbinata ecteinascidins iv( 1) ecteinascidins iv( 1) ectocarpene 264 Ectocarpus siliculosus metabolites 264 Ectyoplasia ferox fatty acids 164 edudione 282 eduenone 282 edulinine 606 edulitine 606 edunol 282 edunone 282 egenine 393 egonol synthesis 70 ehletianol C 69 ehletianol D 67 Ehretia ovalifolia neolignans 67 oligomeric lignans and neolignans 69 Eichhornia crassipes quinoline alkaloids 607 eicosa-5,9-dienoic acid 6-bromo- 281 eicosa- 12,14-dienoic acid 12,15-epoxy-13,14-dimethyl- eicosapentaenoic acid 164,459 eicos-3-en-1-yne 5-hydroxy- 16-methyl- 270 elaeocarpidine 416 Elaeodendron buchananii mutangin 89 elaiomycin biosynthesis 449 elatine pharmacology 196 elatosides 672 eleganolactone epoxy- 265 elemane 151 elema-1,3,11-trien-8,12-olide, 151 a-elemene synthesis 151,504 p-elemene synthesis 151 elemi gum monoterpenoids 486 elemol NMR 15 1 elenic acid 270 Elephas maximus pheromones 86 elicitins 93 elijopyrones 260 ellipticine 572-573 ellipticine Nb-acyldihydro- synthesis 572 ellipticine 9,ll -dihydroxy- synthesis 572 ellipticine 9-hydroxy- synthesis 572 ellipticinium salts 2-aminoethyl- synthesis 572 elminthosporin 55 1 Elsholtzia blanda monoterpenoids 480 Elsholtzia incisa monoterpenoids 480 elymoclavine synthesis 421 emarginatines 639 emarginatinine 639 Emericella desertorum coumarins 466,473 Emericella falconensis falconensoneA iii(6) emetine 395 Emil ian ia h uxley i eicos apen t aenoic acid 459 emmotin Z 152 emmottene 254,283 Empetrum nigrum antimicrobial agents 93 triterpenoids 662 Enantia chlorantha berberines 392 encecalin 86 Encelia farinosa terpenoids 86 Endospermum diadenum diterpenoids 248 enediyne antibiotics 102-104 enediynes 108,541 synthesis 36,63 1 enhydroecgonine 648 epilupinine (4’-hydroxy-3’-methoxy- enoylacylACP reductase fatty acid cinnamoy1)- 35 biosynthesis 338 epilupinine,3-methoxy-4-a-~-rhamnosyloxy-enshuol 267,661 cinnamoy1)- 34 Entandrophragma cylindricum squalene epilupinine (3 ’-methoxy-4’-a-~-rhamnosyl-triterpenoids 66 1 ox ycinnamoy1)- 35 Entandrophragma utile triterpenoids 668 epimagnolin A 54 Enterobacter cloacae P-lactamases 3 10 13-epimanoyl oxide 246 enterodiol 43 22,26-epiminocholest-5-en-~-ol, 200 enterolactone 43 epimodhephene synthesis 150 Enteromorpha intestinalis tryptamines 4 16 1 4-epimoss ambine ,synthesis 571 Enterospermum pruinosum saponins 672 epimyrtine 32,619 entilin D 668 3-epinaucleidinal 560 Enura amarinae phenolic glycosides 90 1-epinitraramine 647 enzymes fatty acid reactions 173-174 epinodosinol iii(4) Ephedra spp.quinoline alkaloids 11 Epipedobates bassleri quinoline alkaloids ephedrine dithio- synthesis 387 15 ephedrine estimation 387 Epipedobates tricolor pumiliotoxins 29 ephedrine N-methyl- configuration 387 Epipolaris kushimotoensis umabanol iii( 5) ephedrine thio- synthesis 387 20-epipseudovincadifformine,578 17-epiajmalicinine 559 epiraikovenal 158,263 3-epialeuritolic acid 2P-hydroxy- 672 ent-epiraikovenal 458 epialloyohimbine 18-hydroxy- 560 epirarisetenolide 458 epiandrosterone dehydro- crystal structure episamarcandin 465 373 3-epischelhammericine 404 epibaptifoline 629 630 16-episilicine 6-0xo- synthesis 566 567 epibatidine 29 7-episinococculine 402 structure 640 14-episinomenine 400 24-epibrassinolide 5,7,8 8a-epislaframine 22 structure 2 1 1 -epispathulenol 264 24-epibrassinolide epitaondiol 254,265 25-~-~-glucopyranosyloxy- 13-epitaxol synthesis 252 8 24-epibrassinolide 17-epitestosterone synthesis 378 26-P-~-glucopyranosyloxy- epithuriferic acid 59 8 24-epibrassinolide 25-hydroxy- 8 20-epiuleine synthesis 572,573 8a-epicastanospermine 25 19-epivoacristine 578 8-epicastanospermine 1 -deoxy- 25 3-epi-a-yohimbine 560 8a-epicastanospermine 6-deoxy- 25 epolactaene 261 2-epicastasterone structure 2 epoxidation steroid alkenes 374 3-epicastasterone 7 Equisetum arvense brassinosteroids 4 structure 2 Equisetum spp.fatty acids 167 3-epicastasterone 6-deoxo- structure 2 eremantholideA synthesis 15 1 24-epicastasterone 8 eremophila-9,11( 13)-dien-12-01 153 structure 2 Eremophila georgei 24-epicastasterone 6-deoxo- 2,3 cyclic diterpenoids iii(6) structure 2 sesquiterpenes 149 epicoriolin synthesis 494 eremophilanes 153-155 155,460 1-epicrassicaudine 191 5a-ergostan-6-one 3P,22-dihydroxy- 2 epicubenol 128 ergosterol mass spectrum 373 biosynthesis 128 149 ergot alkaloids 421 v(5) biosynthesis 364 epicyclosantanal 148 erigerolide 157 20-epidasycarpidone synthesis 572,573 Erigeron annuus putaminoxin 92 4’-epidaunomycin 100 erinacine E iii( 1) epididemnin A 290 Eriocrania cicatricella pheromones 86 3-epidolichosterone 2-deoxy-25-methyl- eriolanin synthesis 153 structure 3 Eriostemon brucei sesquiterpenes 157 2-epidolichosterone Eriostemon cymbiformis coumarins 466 23-0-glucosyl-25-methyl- 470 structure 3 Eriostemonfitzgeraldii sesquitespenes 155 2-epidolichosterone 25-methyl- structure 3 Eriostemon gardneri quinoline alkaloids 1 1 4’-epidoxorubicin 100 Eriostemon myoporoides coumarins 466 epielaeocarpidine 4 16 469 20-epiervatamine synthesis 567 Erodium cicutarium monoterpenoids 480 20-epiervatamine 19-hydroxy- synthesis erucic acid 164 567 ervatamine 19,20-didehydr0- synthesis 567 7-epifunicolideA 285 ervatamine synthesis 567 3-epigeissoschizine 56 1 Erwinia uredovora geranylgeranyl 3-epigibberellinAI 25 1 diphosphate synthase 1 15 3-epigibberellinA63 251 Erysinum cheiranthoides glucosinolates 90 13-epihomoverrucosane 254 Erysiphe graminis fatty acids 164 epiibogamine synthesis 578 Erythrina alkaloids 404-405 epijuvabione 147 D-erythritol 2-C-methyl- biosynthesis iv(5) Epilachna spp.pyrrolo[2,1 -b]oxazoIes iii(6) erythrodiene synthesis 158 281 Epilachna varivestis erythromycin 104,523 pyridone alkaloids 641 biosynthesis 435 pyrrolidine alkaloids 638 erythromycin A 533 8-epiloganic acid 508 erythromycinC &,-r-anhydro- 533 epilupinine 21 35 619,629 630 erythromycin PKS 533 Subject index Erythronium japonicum brassinosteroids 4 erythronolideB 6-deoxy- 523,533 biosynthesis 534 erythronolideB 5,6-dideoxy-S-oxo- 533 Erythropodium caribaeorum metabolites 28 1 Escallonia myrtoidea iridoids 508 Escherichia coli ACP synthetase 337 cyclopeptide alkaloids 79 fatty acid biosynthesis 336 cyclopropanated 338 fatty acid synthase 339 isopentenyl diphosphate 113 isopentenyl diphosphate isomerase 595 P-lactamases 310 marinostatins 455 menaquinones v(6) ubiquinones v(6) vitamin B6 biosynthesis v(2) Escholtziaspp.benzylisoquinoline alkaloid biosynthesis 362 esculentosides 672 esculetin determination 465 synthesis 470 E-selectin 99 Esenbeckia almawillia quinoline alkaloids 11,606 Esenbeckia grandflora coumarins 466,468 quinoline alkaloids 605,606 Esenbeckia hieronimi quinoline alkaloids 605,606 eseroline deoxy- synthesis 420 esmeraldic acid 446 esmeraldins 446 biosynthesis 447-448 esperamicin 102 104 esperamicinAI 54 1 542 esperamicin C 103 essential oils analysis 477 esters keto reduction Saccharomyces cereviciae,vi(2) 14a,15~t-[~Hlestra-4,9-dien-3-one 17a-cyanomethyl- 17P-hydroxy- synthesis 377 estradiol 16-(bromoalky1)- synthesis 376 estradiol 6,6-dimethyl- synthesis 376 estradiol 2-ethoxy- synthesis 376 estradiol 2-methoxy- pharmacology 376 estradiol 6-0x0- synthesis 376 estradiol 2-(prop- 1 -enyl)- synthesis 376 estradiol 17P-hydroxy steroid dehydrogenase 376 estradiols NMR 373 solid NMR 373 estranes partial synthesis 376-377 estra- 1,3,5( lo) 14-tetraen-1q-01 3-methoxy- epimerization 377 estra- 1,3,5( lO)-trien-7-0neoxime 3-methoxy-6a 17P-dihydroxy- synthesis 376 estra-1,3,5( lo)-trien-17-one 1 -mercapto-4-methyl- synthesis 376 A4-estren-3-one 19-nor- 17P-hydroxy- 17a-trifluoromethyl- synthesis 377 estrogen-15-N-acetylglucosaminide 15a-hydroxy- synthesis 376 estrogens 12a-amino- synthesis 376 estrogens 12a-aminomethyl- synthesis 376 estrone 3-methoxy- alkylation 375 estrone-3-acetate 1 1-0x0- 17-ethylene ketal synthesis 376 ethanolamines,bis(9-thiaoctadecanoy1)-phosphatidyl- biosynthesis 343 Ethulia conyzoides monoterpenoids 477 spiro-ethuliacoumarin 477 ethylamine,N-acyl-3,4-dihydroxyhenyl- 394 ethylamine P-phenyl- alkaloids 387-41 1 ethylene perchloro- 459 ethylene trichloro- 459 etoposide 44 etorphine dihydro- pharmacology 404 etorphine pharmacology 403,404 eubacteria fatty acid biosynthesis 336-343 pol yke tides 524-544 eucalyptone 157 Eucalyptus blakelyi monoterpenoids 505 Eucalyptus calmadulensis monoterpenoids 480 Eucalyptus denticulata monoterpenoids 480 Eucalyptus globulus sesquiterpenes 157 Eucalyptus goniocalyx monoterpenoids 480 Eucalyptus nitens monoterpenoids 480 Eucalyptus patens monoterpenoids 480 Eucalyptus perriniana monoterpenoids 486,498,504 Eucalyptus spp.leaf oils 478 terpenoids 86 Euchfoe hyantis nickel hyperaccumulation 86 Eucommia ulmoides monoterpenoids 505 eudesma-5,7(1l)-dien-&one synthesis 153 eudesmane 151-153 synthesis 494 eudesmane 10-desmethyl- 1 -methyl- 153 6-eudesmen-4a-01 synthesis 153 eudesmin synthesis 56 a-eudesmol NMR 153 P-eudesmol NMR 153 y-eudesmol NMR 153 Eudistoma rigida pyrrole alkaloids 637 eudistomins 415,416 eudistomin U structure 290 Eugenia brasifensis monoterpenoids 480 Eugeniaplicato-costata monoterpenoids 480 Eugenia schuechiana monoterpenoids 480 Euglena gracilis fatty acid biosynthesis 345 4a-methylsterols 455 Euglena spp.fatty acid biosynthesis 335 Euglenoidea secondary metabolites 455 Euglenoids secondary metabolites 455 Euglenozoa secondary metabolites 455 euglobal-B 1- 1 505 eukaryotic algae fatty acid biosynthesis 344-345 Eumycota secondary metabolites 45946 1 Eunicea laciniata diterpenoids 253 metabolites 282 Eunicea mammosa cembranes 252 metabolites 282 Eunicea tourneforti diterpenoids 253 metabolites 282 Eunicella cavolini metabolites 284 eunicellane iii(3) eunicellin 284 euonyminol synthesis 153 Euonymus japonicus sarmentosin 84 Euonymus spp.sesquiterpenes 153 eupatoriopicrin 157 Eupatorium portoricense pyrrolizidine alkaloids 658 Eupatorium stoechadosmum monoterpenoids 486 euphactins 253 19(10+9)-abeo-eupha-5,24-dien-$-ol 666 euphane triterpenoids 665-669 euphoractines 253 Euphorbia aleppica diterpenoids 253 Euphorbia boetica triterpenoids 666 Euphorbia calyptrata ergot alkaloids 421 Euphorbia lathyrus triterpenoids 663 Euphorbia micractina diterpenoids 253 Euphorbia myrsinites diterpenoids 253 Euphorbia paralias paralinone iii(3) Euphorbia prolifera diterpenoids 253 Euphorbia sequieriana diterpenoids 249 euphoreppines 253 Euplotes crassus euplotins 457 Euplotes focardii focardin 458 iii(2) Euplotes quinquecarenatus focardins 458 Euplotes raikovi metabolites 263 preraikovenal 457 sesquiterpenes 158 Euplotes rariseta rarisetenolide iii( 2) Euplotes vannus euplotins 457 euplotins 457 eupodienones 6 1 eupomatenoids NMR 66 Euryspongia rosea fatty acids 164 eusiderin 68 Eustigmatophyceae secondary metabolites 459 Eustigmatophytes secondary metabolites 459 Evodia fatraina quinoline alkaloids 11 Evodia meliaefolia quinoline alkaloids 606 Evodia merrillii furoquinoline alkaloids 608 quinoline alkaloids 606 Evodia roxburghiana furoquinoline alkaloids 608 quinoline alkaloids 606,608 Evodia rutaecarpa quinoline alkaloids 1 1 13 evodone synthesis 494 evolatine 11 evolitrine 11 evomeliaefolin 605,606 evomerrine 606,608 evoxine 606 mass spectroscopy 609 excelsioside 123 exochomine 634 Exserohalium turcicum monocenn 93 F F1839-A 146 Fagara nitida quinoline alkaloids 606 Fagara zanthoxyloides quinoline alkaloids 11,14 y-fagarine 11 14 606 fagaropsin 669 Fagaropsis glabra triterpenoids 669 Fagopyrum esculentium brassinosteroids 4 falconensoneA iii(6) fangchinoline 390 farinosin 86 Farfowia mollis fatty acids 165 farnesane 145 a-farnesene 91 145 P-farnesene 86 125 farnesiferolC structure 147,465 farnesolic acid 2,3-dihydro- terpenoids 86 farnesol phosphokinase 145 farnesyl diphosphate biosynthesis 1 14 59 1 farnesyl diphosphate synthase 1 14 farnesylgeranyl diphosphate synthase 1 15 farnesyl oleate 9-hydroxy- 145 farnesyl sulfone biomimetic cyclization 145 fascaplysin 424 Fascaplysinopsis reticulate fatty acids 165 Fascaplysinopsis spp.bisindole alkaloids 424 Fasciospongia cavernosa metabolites 280 fatty acid allene oxides biosynthesis 174 fatty acids 163-189 acetylenic 164 biosynthesis 346 synthesis 167 2-alkyl synthesis 167 4-alkyl synthesis 167 6-alkyl synthesis 167 autoxidation 173- 174 biosynthesis 177-179,335-358 books 163 branched-chain 164 carbocyclic synthesis 169-170 column chromatography 174 cyclic 164-165 cycloheptyl biosynthesis 438440 cyclohexyl biosynthesis 437438 cyclopropanated biosynthesis Escherichia coli 338 cyclopropane esters synthesis 169 dimethylated furan biosynthesis 348 epoxy synthesis 168 extraction 175 Fourier transform infrared spectroscopy 176 furan synthesis 170 furanoid 166 gas chromatography 175-1 76 halogenated 171-172 0-heterocyclic synthesis 169-170 high performance liquid chromatography 174-175 hydrogenation 173 3-hydroxy- biosynthesis 336 hydroxy C,*,synthesis 167-168 infrared spectroscopy 176 isotope-labelled synthesis 172- 173 mass spectrometry 176-1 77 methyl-branched synthesis 167 methyl esters synthesis gas chromatography 175 nitrogen-containing synthesis 170 NMR 176 occurrence 163-1 67 olefinic synthesis 167 oxa synthesis 168 0x0 synthesis 168 oxygenated 165-1 67 periodicals 163 peroxidation 173-1 74 physical properties 174 pyrazole synthesis 170 reviews 163 selenium-containing synthesis 171 structure 163-167 sulfur-containing synthesis 17 1 supercritical fluid chromatography 175 synthetic 167-1 73 tellurium-containing synthesis 17 1 thin layer chromatography 174 thiophene synthesis 171 unbranched 163-1 64 unusual synthesis 169-17 1 fatty acid synthetases fungi 345 fatty esters unsaturated hydrogenation 173 fatty hydroxamic acids synthesis 177 febrifugine 6 13 fellutamides 461 fench anes 504-5 05 fenchone biotransformations 504 fenchone- 10-sulfonic acid synthesis 504 fenchyl hydrazone reaction with tert-butyl methyl ketone 504 fernene 9a,1 la-epoxy- 675 ferruginol 249 ferruginol 1-0x0- 249 ferruginol 6-0xo- 249 1-16 Natural Products Reports 1997 fersoridin structure 148 fersorin structure 148 Ferula assafoetida coumarins 465,466 Ferula karakalensis sesquiterpenes 155 Ferula spp.sesquiterpenes 148 sesquiterpenoids 147 Festuca argentina lignans 54 filamentous actinomycetes polyketides 525 filic-4(23)-ene 3a,lOa-epoxy- 675 filiformin synthesis 148 filiformin debromo- synthesis 148 Filoboletus spp.fatty acids 165 fimbrolide synthesis 266 Fischerella ambigua bisindole alkaloids 424 Fissidens adianthoides fatty acids 164 fitterazine 294 FK-506 25,536 biosynthesis 436 FK-506,3 1 -0-desmethyl- 536 FK520 536 biosynthesis 436437 flavanoids biosynthesis genes 552 flavin reductase P Vibrio harveyi v( 1) Flavobacterium spp. metabolites 259 260 Flavobacterium uliginosum marinactam 455 flavochristamides 259 flavonoids biosynthesis 433 oviposition stimulants 90 flavonolignan 70 flavopereirine 560 synthesis 560 flavopereirine 5,6-dihydro- 560 Flexibacter spp. fatty acid biosynthesis 336 flexinine 304 fliederoside 123 flindersiamine 606 flindersine 7-methoxy- 606,608 flindersine N-methyl- 14 flindersine N-methyl-7-prenyloxy- 606,608 flindersine 7-prenyloxy- 606,608 flucloxacillin 309 Fluorensia cernua monoterpenoids 480 fluorine bioorganic chemistry v(4) Flustra foliacea metabolites 286 flustramides debromo- 286 flustramines debromo- 286 focardin 458 iii(2) focardin epoxy- 458 Foeniculum vulgare monoterpenoids 480 Fontanesia fortunei secoiridoids 123 Fontanesia phillyreoides iridoids 508 secoiridoids 123 formate dehydrogenase amino acid synthesis 206 formosanoxide 249 forskolin 246 synthesis 506 Forsythia europaea monoterpenoids 507 Forsythia koreana lignans 43 Forsythia spp.iridoids 121 lignans 43 45 Forsythia viridissima monoterpenoids 507 forsythide 12 1 forsythide 1 1-methyl- 121 fortesol 496 fragranol synthesis 477 frangufoline 79 frangufoline N-desmethyl- 77 frangulanine 75 fraxetin 471 Fraximus angustifolia iridoids 508 fraxinalacoside 508 fraxinol 465 Fraxinus excelsior secoiridoids 123 Fraxinus insularis iridoids 508 Subject index Fraxinus malacophylla iridoids 508 Fraxinus ornus iridoids 508 G ~ Fraxinus spp. oleosides 123 Fraxinus uhdei iridoids 508 GAI fraxuhdoside 508 biosynthesis 226,227,228,232,234,236 frechitine 191 stereochemistry 238 frenolicin 526 2P-hydroxylation 23 1 friedelane 673 metabolism 229,230 friedelane-3,7-dione 673 oxidases 236 friedelan-29-oic acid 2a-hydroxy-3-oxo- 3-epi-GAl metabolism 230 673 GA3 friedel-3-ene 674 biosynthesis 228,221,222,231,232,233 friedelin 674 metabolism 229,230,240 friedelin 7P,8P-epoxy- 673 GA4 Fritillaria ebeiensis diterpenoids 250 biosynthesis 226,228,231,232,234 Fritillaria maximowiczii metabolism 229,230 alkaloids 197 oxidases 236 indolizidine alkaloids 625 GA5 Fritillaria siechuanica alkaloids 198 200 biosynthesis 228,231,236 Fritillaria taipaiensis alkaloids 198 stereochemistry 238 Fritillaria yuminensis alkaloids 198 metabolism 229,230 fritillebic acid 250 GA6 biosynthesis 228 236 fritillebins 250 GAi frogs alkaloids 623 biosynthesis 228,232,233 240 Fromia monilis metabolites 294 stereochemistry 238 fromiamycalin 294 metabolism 229 Frullania spp.oleanane triterpenoids 671 GA8 fi-utoic acid 250 biosynthesis 228,231 9'-fucoxanthinone 145 stereochemistry 238 fudecalone 146 metabolism 229,230 Fuga poeciilonotus metabolites 294 GA9 fuhalol 265 biosynthesis 226,228,231,232,233 fuhalol deshydroxy- 265 233,234,236,239 fulvanin synthesis 146 metabolism 229,230 fumiquinazolines 26 1,4 18,46 1 oxidases 236 structures 612 GA9,2,3-dehydro- biosynthesis 228 fumitremorgin C demethoxy- 4 18 GA9,2P,3P-epoxy- biosynthesis 228 funebral 637 A1-GA9 biosynthesis 233 fungi GA11 biosynthesis 233 fatty acid biosynthesis 345-346 GA12 filamentous fatty acid biosynthesis 346 biosynthesis 23 1,234 marine secondary metabolites 453464 metabolism 230,234 polyketides 545-55 1 oxidases 236 secondary metabolites 45 9-46 1 GA12,2P-hydroxy- biosynthesis 23 1 funicolides 253 285 GA13 biosynthesis 228 233 Funiculina quadrangularis GA14 diterpenoids 253 biosynthesis 231,232,233,235 metabolites 285 metabolism 234 furan tetrahydro- 52-54 GA15 biosynthesis 226,233,234,236,239 furan-2-acetic acid 5-hexyltetrahydro- 179 GA15 12a-hydroxy- biosynthesis 23 1 furanether B synthesis 150 GA16 biosynthesis 232,233 furan fatty acids synthesis 170 GA17 furanocoumarins 88,95 biosynthesis 228,236,239 biosynthesis 592 metabolism 229,230 extraction 465 GA19 furanocoumarins dihydro- spectroscopy biosynthesis 235,236,239 465 stereochemistry 238 furanoditerpenes 245 metabolism 229,230 synthesis 279 oxidases 236 furanoterpenes sulfated 279 GA20 furo[2,3,4-kl]acridines,synthesis 61 7 biosynthesis 226,233,236,239 furodysin 279 metabolism 229,230 synthesis 158 oxidases 236 furoparadine 18 GA23 furoquinoline alkaloids 14 biosynthesis 228 rutaceous 608-609 oxidases 236 Fusarium culmorum GA24 monoterpenoids 478 biosynthesis 226,228,233,234,236,239 trichodiol 127 stereochemistry 238 Fusarium oxysporum phytoalexins 95 metabolism 229,230 Fusarium sporotrichioides oxidases 236 trichodiene synthase 126 GA25 biosynthesis 228,233,234,236,239 trichothecenes 127 GA25 12a-hydroxy- biosynthesis 231 Fusarium spp.halymecins 461 GA28 biosynthesis 228 Fusarium subglutinans diterpenoids 254 GA29 fuscol methyl ether 253 biosynthesis 228 236 fusicoccanes 254 metabolism 229,230 fusidane triterpenoids 662-665 GA32 biosynthesis 23 1 fuziline 191 GA34 metabolism 229 1-17 GA36 biosynthesis 228,233 GA37 biosynthesis 227,233 GA37 12a-hydroxy- biosynthesis 231 GA38 biosynthesis 227,228 GA39 biosynthesis 231 GA40 biosynthesis 233 GA43 12a-hydroxy- biosynthesis 231 GA44 biosynthesis 226,227,228,235,236,239 metabolism 229,230,231 oxidases 236 GA47 biosynthesis 232,233 GASI biosynthesis 228 GAs3 biosynthesis 227,228,235 metabolism 229,230,23 1 oxidases 236 GAs3 l5P-hydroxy- biosynthesis 231 GAB biosynthesis 231 GA71 biosynthesis 23 1 GA73 biosynthesis 23 1 GA75 biosynthesis 23 1 GAs6 biosynthesis 23 1 GAs8 biosynthesis 23 1 GA92 biosynthesis 240 GA95 metabolism 240 GA96 biosynthesis 23 1 GA97 biosynthesis 23 1 GA98 biosynthesis 23 1 GA99 biosynthesis 23 1 GAw biosynthesis 23 1 GA107 biosynthesis 23 1 GA C19,2P-hydroxylation 23 1 GA 9,ll -dehydro- biosynthesis 240 GA 9,11-didehydro- biosynthesis 226 23 1 GA 1 1 -hydroxy- biosynthesis 226 GA 15-hydroxy- biosynthesis 240 GA 15P-hydroxy- biosynthesis 226 GA 12a-hydroxy-C~ biosynthesis from 12a-hydroxy-Czo-GA 226 GA 12a-hydroxy-C20- conversion to 12a-hydroxy-Cls-GA 226 GAI 3-7-aldehyde biosynthesis 23 3 GAlz-aldehyde 136 biosynthesis 222 conversion to C19-GA 226 conversion to CzO-GA 226 metabolism 228 GA~aldehyde biosynthesis 23 1,232,235 GAss-aldehyde biosynthesis 227,235 GAlz-aldehyde 7-oxidase 235 GA13- 19,20-anhydride biosynthesis 233 gabaculine,3-amino-5-hydroxybenzoicacid synthase inhibition 442 gadain 49 gadesine dihydro- 194 GA-dioxygenases 235 GA12-2-en-7,19-diol biosynthesis 236 GAI -3P-O-glucoside biosynthesis 23 1 GA3-3P-O-glucoside biosynthesis 23 1 GA1-3P-0-glucuronic acid biosynthesis 231 gaigrandin 157 Gaillardia grandifora sesquiterpenes 157 galactostatin 645 galanthamine 304,305,306 synthesis 307 galanthamine 0-acetyl- 304,306 galanthamine N-demethyl- 304,305,306 galanthine 304 305,306 Galanthus elwesii alkaloids 305 galasine 304,305 Galbulimima baccata piperidine alkaloids 644 galcatin 46 galioside 10-benzoyl- 508 Galipea longifZora quinoline alkaloids 607 gallotannins 88 galwesine 304,305 galwesine 9-0-demethyl- 304 305 galwesine 16-hydroxy- 304,305 1-18 Natural Products Reports 1997 galwesine 16-hydroxy-9-0-demethyl- 304 305 Gambierdiscus toxicus ciguatoxin 457 gambieric acids 457 gambierol 457 16-gammacerene 676 Ganoderma applantum monoterpenoids 482 Ganoderma lucidum triterpenoids 662 Ganoderma mastoporurn sesquiterpenes 149 Ganoderma neogaponicum cryptoporic acid 131 ganomastenols 149 GA12 20-oxidase 235 GA15 3P-oxidase 235 GA 20-oxidases 236,239-240 GA oxidases 235 specificity 236 Garberia heterophylla diterpenoids 253 sesquiterpenes 156 garberic acid 253 garcilipene iii(5) gardendiol 508 CD spectra 507 Gardenia jasminoides iridoids 508 linalool 478 monoterpenoids 498 Gardenia lucida fatty acids 166 Gardeniaspp.3,4-secocycloartanes iv(2) gardenone 508 CD spectra 507 gardenoside 508 gardoside 7-0-p-hydroxybenzoyl- 509 Gastophysa viridula iridoids 124 gastrolactone synthesis 510 Gastrophysacyaneaspp. iridoids 5 10 Gastrophysa viridula 8-hydroxygeraniol 84 gauttegamerine biosynthesis 361 geese toxins 88 geibalansine 9-methoxy- 12 Geissman-Weiss lactone synthesis 655 geissoschizine stereostructure 561 synthesis 562 geissoschizine deformyl- conversion into geissoschizine 562 synthesis 561,571 geissoschizine 1 0-methoxy -16-deformyl- synthesis 564 geissoschizol 9-methoxy- 559 geissoschizol 10-methoxy- 559 geldanamycin biosynthesis 440,441,535 gelluisines 275 gelsamydine 19a-hydroxy- 565 gelsemide 7-deoxy- 508 gelsemide 9-deoxy- 508 gelsemine 565-568 synthesis 567 Gelsemium elegans iridoids 508 monoterpenoid indole alkaloids 565 Genipa americana monoterpenoids 507 genipin 51 1 geniposide deoxy- 5 10 geniposidic acid 123 Genista aucheri alkaloids 34 Genista carinalis alkaloids 34 Genista lobelii alkaloids 628,629 Genista salzmanii alkaloids 628 Genista spp.alkaloids 35 Gentiana depressa iridoids 508 Gentiana formosana iridoids 508 Gentiana macrophylla iridoids 508 Gentiana spp. monoterpenoids 507 geodiamolide G 270 geosmin dehydro- 132 geraniol 91,92,478,482,483,484 biosynthesis iv(5) epoxidation 483 osmylation 483 geraniol 8-hydroxy- 84 8-glucoside 84 geraniol 13-hydroxygeranyl- 245 geraniol dehydrogenase 482 geraniol 8-hydroxylase iridoid biosynthesis 124 geranyl acetate asymmetric dihydroxylation 483 geranyl diphosphate 482 biosynthesis 114,591 geranyl diphosphate synthase 114 geranyl esters synthesis 483 geranylgeranyl diphosphate biosynthesis 59 1 geranylgeranyl diphosphate synthase 1 15 geranylgeranylglyceryl phosphate synthase 115 geranylgeranyl pyrophosphate ent-kaur- 16-ene biosynthesis 222 geranyl pyrophosphate gibberellin biosynthesis 225 geranyl sulfonamides 483 geranyl 0-P-D-xylopyranosyl- P-D-ghcopyranoside 478 gerberinol 1 1-methyl- 473 germacra-3,10( 15)-diene acetoxy- 15 1,28 1 germacrane 15 1 germacrane A 149 germacra-3,5,10( 15)-triene acetoxy- 151 28 1 germacrene B 9 1 germacrene D v(5) germline antibody v(5) Gersernia fruiticosa fatty acid biosynthesis 344 gesneriodins 25 1 Gibberella fujikuroi diterpenoids 25 1 fatty acids 165 gibberellin biosynthesis stereochemistry 237-239 gibberellins 221 Gibberellal fujukuroi gibberellin biosynthesis 23 1-234 Gibberella pulicaris phytoalexins 96 gibberellic acid 201 gibberellin A1 biosynthesis 25 1 gibberellin A12 13-hydroxy- 251 gibberellin A82 251 gibberellins 25 1 biosynthesis 136,221-243 stereochemistry 237-239 glucosyl esters 25 1 metabolism 228-23 1 gibberellins 15-oxo- biosynthesis 25 1 GI-14721 lC 584 6-gingerol 90 Ginkgo biloba sesquiterpenes 158 ginkgolides biosynthesis 594 detection 158 glabrescol 661 glaucine 397 glaucine 0x0- physiological effects 399 glaucine pharmacology 399 Glaucium arabicum berberines 392 protopines 393 Glaucium corniculaturn aporphines 397 Glaucium flavum aporphines 397 benzylisoquinolines 389 phthalide-isoquinolines 394 protopines 393 glaucolide B reactions 15 1 glaziovine 397 Glechoma hederacea fatty acids 165 Gleichenia japonica diterpenoids 245 Gliocladium spp.bisindole alkaloids 427 GloboH vii(3) globulol I53 Gloephyllum ahietinum oospoglycol v(2) Gloephyllum odorattum monoterpenoids 482 Glomerella cingu la fa biotransformation cedrol 149 sesquiterpenes 145 147 158 glucodigifucoside 90 glucodigigulomethyloside 90 glucose dehydrogenase amino acid synthesis 206 glucose kinase gene Streptomyces coelicolor 444 glucosides cyano- 84 glunone 153 glutamate dehydrogenase amino acid synthesis 206,215 glutamic acid 4-alkylidene- isotope-labelled synthesis 2 10 glutamic acids isotope-labelled synthesis 206,214215 glutam ine isotope-1 abel led synthesis 215-217 glutaric acid 2-0xo- isotope-labelled synthesis 214 glycerate clavulanic acid biosynthesis 321 glycerol clavulanic acid biosynthesis 32 1 glycerol 2,3-diphytanyl- biosynthesis 343 glycerol geranylgeranyl- 245 glycerols monoacyl- synthesis 178 glycerols triacyl- biosynthesis 177 fatty acid composition determination 175 hydrolysis 177 glycine prop-2-ynyl- deuteriated synthesis 214 Glycine max brassinosteroids 5 glycoalkaloids 196 glycobiology 99 glycocitridine 605 606 608 glycocitrine-I 6 15 glycocitrine-11 61 6 glycofolinine 6 14,6 15 glycoluril tetramethyl- 354 glycopeptides I04 glycoside L-6d 672 Glycosmis citrifolia acridone alkaloids 614,615 quinoline alkaloids 605,606 Glycyrrhiza inflata oleanane saponins 672 Glycyrrhiza yunnanensis oleanane triterpenoids 67 1 glyfoline 19 glyyunnansapogenin 67 1 Gnoxys acostae sesquiterpenes 155 Gnoxys busifolia sesquiterpenes 155 gomisin A 45,48 gomisin 0,0-benzoyl- 61 Goniodoma pseudogonyaulax goniodomins 457 goniodomins 457 goniomitine synthesis 575 goniomitine 16-hydroxymethyl- synthesis 575 Gonocytisus angulatus alkaloids 629 Gonocytisus dirmilensis alkaloids 629 gonolactone A 662 Gonyaulaxpolyedra sulfonium compounds iv(5) 11-goriacerol 283 Gossypium barhadense sesquiterpenes 128 Gossypium hirsutum tj-cadinene 128 isopentenyl diphosphate isomerase 597 sesquiterpenes 149 153 gossypol 128 Gracilaria edulis metabolites 266 Gracilariopsis lemaneiformis Subject index fatty acids 165 166 12-1ipoxygenases 179 gracilins 279 grahamidiol 674 gramine 92 graminones 54 Gram negative bacteria fatty acid biosynthesis 336-339 polyketides 524-525 Gram positive bacteria fatty acid biosynthesis 339-343 polyketides 525-544 granaticin 528 grandirubrine 400 grandisinine 615 grandisol synthesis 477 gravelliferone 468 graveoline 3’,8-dimethoxy- 605 graveoline 3’-methoxy- 605 green algae metabolites 263-264 Grindelia tarapacana diterpenoids 245 grindelic acid 17-0xo- 92 grisabine dimethyl- 390 griseusin 528 grossularine- 1 290 grossularine- 1 N,N-didesmethyl- structure 423 grossularine-2 290 grossularines 414 Guaiane 155-157 guaian-6a 12-0lides 156 guaianolides 156 guaiaretic acid 3-0-methylnordihydro- 44 guaiol NMR 156 guia-3,10( 15)-dien-7,11 -epoxy-@acetate 28 1 guia-6,9-dien-4-01 28 1 guianin 67 gusanlung C 393 gusanlung D 392 gymnodimine 263 Gymnodinium breve brevetoxin A 456 metabolites 263 Gymnodinium spp.metabolites 263 Gynmodinium kowalevskii fatty acids 164 Gynocardia odorata diterpenoids 250 Gynostemma pentaphyllurn triterpenoids 666 Gynostemma yixingense triterpenoids 666 Gypsophila capillaris saponins 672 Gypsophila oldhamiana saponins 672 Habronestes bradleyii 6-methyl-5-hepten-2-one 85 Hacquetia epipactis oleanane saponins 672 hacquetia saponins 672 haemanthamine 303,304,306,307 haemanthidine 304 Haemanthus albiflos alkaloids 304 Haglophyton crooksii monoterpenoid indole alkaloids 580 halenaquinone biosynthesis 545 halichlorine 633 halicholactone 270 Halichondria cylindrata metabolites 270 274 Halichondria okadai alkaloids 633 metabolites 270 halichondrin B 270 Haliclona spp.metabolites 270,274,279 sesquiterpenoids 145 halicyclindramides 274 halicylindrosides 267 halimane 246 Halimium viscosum diterpenoids 245 halistatin 3 270 halisulfate 280 Halobacterium cutirubrum fatty acid biosynthesis 343 isopentenyl diphosphate 1 13 Halobacterium halobium lipid biosynthesis enzymes 1 15 halymecins 461 hamayne 304,305 hamayne 3-0-acetyl- 304,305 Hamigera taragensis metabolites 279 hamiltonins 288 Huminoea navicula metabolites 288 haminols 288 Handelia trichophylla sesquiterpenes 156 handelin structure 156 hanishenol B iii(3) 12-epi-hapalindoleQ isonitrile 262 12-epi-hapalindoles 262 Hapalosiphon laingii metabolites 262 hapepunine 3-0-P-cellobioside 197 haplaindole-Q synthesis 500 haplamine 606,608 haplodocin 48 haplomyrfolin 48 Haplopappus diplopappus diterpenoids 245 Haplophyllum cappadocium lignans 48,62 Haplophyllumperforatum quinoline alkaloids 606 607 Haplophyllumptilostylum lignans 48,57 Haplophyllum spp.quinoline alkaloids 14 Haplophyllum vulcanicum quinoline alkaloids 606 haplophytine 580 Haplophyton crooksii monoterpenoid indole alkaloids 560 565 568 573 haplopine 606 haploporic acid A 146 Haploporus odorus sesquiterpenoids 146 haplosamine 606,607 Haptomonoda secondary metabolites 459 harpagide 122 Harrisonia abyssinica 12P-acetoxyharrisonin iv(6) Harrisonia pegorata triterpenoids 668 harrisonin 12P-acetoxy- crystal structure iv(6) hamsonin iv(6) hasakol 466 hastanecine synthesis 653 hastanecine 7-angelyl- 658 hastanecine 9-angelyl- 658 Hebeloma senescens triterpenoids 662 hebelomic acids 662 Hedera helix monoterpenoids 480 oleanane saponins 672 Hedera taurica oleanane saponins 672 hedycariol 15 1 Hedychium coronarium monoterpenoids, 480 Heimia montana Lythraceae alkaloids 627 Heimia salicifolia Lythraceae alkaloids 32 heinsigenin A 664 heldrichinic acid 249 helenanin 157 Helenium spp.sesquiterpenes 157 Helianathus annuus brassinosteroids 4 heliangolides structures 151 Helianthus annuus scopoletin 95 sesquiterpenes 132 terpenoids 86 helibracteatine 657 helibracteatinine 657 helicascolides 460 Helicascus canaloanus helicascolides 460 Helicoverpa zea induced chemical defence 89 1-19 pheromones 86 heliosupine 657 heliosupine 3’-acetyl- 657 heliotridane synthesis 653 heliotridane dihydroxy- synthesis 655 heliotridine 658 heliotrine 83 Heliotropium arborescens pyrrolizidine alkaloids 657 Heliotropium bracteatum pyrrolizidine alkaloids 657 Heliotropium europaeum alkaloids 658 Heliotropium scabrum pyrrolizidine alkaloids 657 heliscabine 657 hemiasterlins 270 416 hemibrevetoxin B synthesis 263 hemigossypol 128 Hemimycale spp.metabolites 274 hemiterpenoids biosynthesis 1 12-1 13,59 1 heneeicos-4-en- 1-yne 3-hydroxy- 270 hennoxazole A 270 Henricia downeyae metabolites 294 hepoxilin B3,biosynthesis 344 hepoxilin B4 165 heptadeca-2,4-dienal 2-(tridecy1)- 266 heptadeca- 10,12-dienoic acid 10,13-epoxy- 170 heptadecanoic acid 17-iodo- C-isotope labelled synthesis 173 heptadecanoic acid 3-methyl- C-isotope labelled synthesis 173 heptadec- 1 O-en-2-one biosynthesis 349 heptane- 1,7-dioic acid biosynthesis 354 heptanoate 3-hydroxy-2-oxopropanoyl 7-methyl-3-oxo- biosynthesis 354 heptanoic acid 3,5-dihydroxy-2,4-dimethyl- lactonisation 534 heptano-5-lactone biosynthesis 534 heptan-2-one 9 1 heptelidic acid synthesis 149 hept-6-enoic acid 7-( 2-hexylcyclopentyl)- methyl ester synthesis 169 hept-4-en-2-01 86 hept-5-en-2-one 6-methyl- 85 Heracleum candicans coumarins 465 herbamide A 270 Herba violae coumarins 465 Hericium erinaceum erinacine E iii( 1) Heritiera ornithocephala sesquiterpenoids 148 hernandaline dehydro- 397 Hernandia nymphaeifolia aporphines 397 oxoaporphines 399 Hernandia sonora aporphines 397 bisbenzylisoquinolines 390 isoquinoline alkaloids 387 oxoaporphines 399 hernandonine 399 hernangerine oxo- 399 hernangerine chloride N-methyl- 397 hernangine oxo- 399 hernanymphine 399 Herniariafontanesii oleanane saponins 672 herniaria saponin A 672 herniarin 465 Herpes simplex eudistomins 4 16 Heteranthemis viscedehirta sesquiterpenes 151 heteratisine N-oxide NMR 195 heteroclitins 61,62 Heteronema erecta metabolites 28 1 heterophylloidine 192 heterophylloidine deacetyl- 192 heteroscyphone A 246 Heteroscyphus planus cadinanes v(6) cadinene v(5) cubenene 128 diterpenoids 134 247 sesquiterpenes 128 149 157 heteroscyphyic acid A biosynthesis 134 Heterosigma akashivo secondary metabolites 459 Heterosigma spp.secondary metabolites 459 Heterotheca inuloides sesquiterpenes 149 Heterotropa aspira flavonoids 90 heteroyohimbine 559-565 hetidine 192 hetisan- 13-yl acetate 6,9-dihydroxy-2-0~0- 194 hetisine 194 hetisine 1 1 -@acetate 193 hetisinone 194 Heuchera sanguinea plant defensins 93 Hevea brasiliensis HMG-CoA reductase 112 HMG-CoA synthases 1 11 hexacosanoic acid biosynthesis 340 hexacosanoic acid 2,4,6-trimethyl- biosynthesis 340 hexadeca- 1 1,13-dienoic acid biosynthesis 35 1 hexadeca-l,12-dien-l-o1, biosynthesis 351 hexadecane-1 ,16-dioic acid 7-hydroxy- 165 a,o-hexadecanedioic acid 8-hydroxy- 165 hexadecane- 1 -sulfonic acid 2-amino-3-hydroxy- 15-methyl- biosynthesis 336 hexadecanoic acid biosynthesis 339,343 351,353 hexadecanoic acid 14-methyl- 342 hexadecanoic acid 9,10-methylene- 164 hexadecanoic acid monomethyl- biosynthesis 350 hexadecanoyl ACP 336 synthesis from butanoyl ACP 338 hexadec-7-enoate biosynthesis 338 hexadec-6-enoic acid biosynthesis 348 hexadec- 1 1 -enoic acid biosynthesis 35 1 hexadec-9-enoyl ACP 336 hexadec-13-en-l l-ynoic acid biosynthesis 35 1 hexadec- 13-en- 1 1-ynyl acetate biosynthesis 35 1 hexadec- 1 1 -ynoic acid biosynthesis 35 1 hexanoic acid 4-hydroxy- biosynthesis 339 5-hexanolide 2,4-dimethyl- 85 hexanoyl ACP fatty acid biosynthesis 347 hex-3-enyl acetate 85 heyneanine 578 Hibiscus rosa-sinensis fatty acids 166 higenamine physiology 389 himachalane 149- 150 a-himachalane 149 himastatin structure 424 himbacin 644 himbeline 644 hinckdentine A synthesis 61 1 hinesol synthesis 153 hippadine 304 305 hippeastrine 304,306 Hippeastrum equestre alkaloids 306 Hippocratea excelsa sesquiterpenes 153 hippodamine 634 Hippophae rhamnoides fatty acids 166 Hippospongia metachromia metabolites 278 Hippospongia spp.hippospongic acid A iv( 1) taurospongin A iii(5) hippospongic acid A iv( 1) hirsutane 150-1 5 1 hirsuteine 559 hirsutene 3-hydroxy- synthesis 494 hirsutine 559 hirsutolide structure 15 1 hirtin 89 hispidol B 666 histidine 86 isotope-labelled synthesis 21 5-217 histidine P-hydroxy- nikkomycin biosynthesis 369 HMG-CoA reductase 1 12 HMG-CoA synthase 1 11 holamide 198 202 Holarrhenapubescens alkaloids 198,202 holidinine 404 holmioside 508 holomycin 314 Holothuraflorida triterpenoids 663 Holothuria scabra metabolites 294 homoanatoxin-a 650 homoaromoline 390 28-homobrassinolide 5 7 28-homocastasterone structure 3 homocereulide 260,455 28-homodolicholide structure 3 28-homodolichosterone structure 3 28-homodolichosterone 6-deoxo- structure 3 homoerysotrine 2,7-dihydro- 404 homoerythrina alkaloids 404405 homogentisic acid farnesyl- 145 homogynolide A synthesis 155 homoharringtonine 405 homokiol 44 homolycorine 303 304,306 homolycorine 8-O-demethyl- 303,304 homolycorine 9-O-demethyl- 304 305 307 homolycorine 5-methoxy-9-O-demethyl- 304,305 homoormosanine 34 B-homo-7-oxa-5a-cholestan-6-one 2a,3a,22,23-tetrahydroxy-24-methy 1- 1 B-homo-7-oxa-5a-pregnane-6,20-dione 2a,3P-dihydroxy- 8 homopiptanthine 34 homoprotoemetinol 395 homoshikimic acid 438 homospermidine biosynthesis v(6) homospermidine synthase 361 28-homoteasterone 2 3 structure 3 homotropane biosynthesis 641 28-homotyphasterol 2 3 structure 3 homovermcosan-5~-ol 279 hopane-20a,22-diol 675 hopanes biosynthesis 593 hopane triterpenoids 675 hopanoids biosynthesis 1 13 hopan-28,22-olide 24-hydroxy- 675 hordenine 304 305 pharmacology 387 Hordeum vulgare gibberellin biosynthesis 222,226 hormonal interactions 89 hormothamnin A 454 hormothamnione 459 hormothamnione 6-desmethoxy- 459 Hormothamnion enteromorphoides hormothamnin A 454 horsfiline synthesis 416 hostiine 569 hotrienol 485 Hovenia dulcis triterpenoids 665 hovenidulcigenin A 665 hov enidulc io sides 665 huajiaosimuline 608 human promyelocyte cells isopentenyl diphosphate isomerase 597 Humicola spp.xanthoquinodins 551 humulane 150-151 P-humulene 86 hyalic acid iii(2) 1-20 Natural Products Reports 1997 Hyalis argentea hyalic acid iii(2) hydnocarpic acid dihydro- 165 Hydnocarpus anthelmintica fatty acids 165 Hydrangea macrophylla iridoids 508 hydrastine oxo- 393 394 hydrastinine oxy- 387 hydrastinine chloride 387 h ydroboration androst-4-ene 3 74 Hydrocotyle ranunculoides oleanane triterpenoids 67 1 Hydrodictyon reticulatum brassinosteroids 4 hydrogenation fatty acids 173 hydrogen bonds n-facial vi(2) hydrogen cyanide 92 hydropyridone alkaloids 640-641 hydroquinone 93 hydroquinone geranylgeranyl- 245 hydroquinone 2-prenyl- sulfated 279 hydroxamate inhibitors binding to carbonic anhydrase vii(3) hydroxyacyl ACP dehydrase fatty acid biosynthesis 338 3-hydroxybutanoyl ACP fatty acid biosynthesis 338 hydroxydecanoyl ACP dehydrase 336 fatty acid biosynthesis 338 4-hydroxy-3-indolylmethylglucosinolate 88 13-hydroxylase GAIL 235 12a-hydroxylase GA12-aldehyde 235 3 P-hy drox ylases gibberel 1in bios ynthesis 236 h ydrox ylation steroids artificial P450 v(5) tyrosine hydroxylase v(3) 3 P-hydroxylation GA I 4-aldehyde 235 12a-hydroxylatio11 gibberellin biosynthesis 231 12P-hydroxylation gibberellin biosynthesis 23 1 1SP-hydroxylation gibberellin biosynthesis 23 1 3-hydroxy-3-methylglutaryl-CoA, 594 3-hydroxy-3-methylglutaryl-CoAreductase 95 3a-hydroxysteroid dehydrogenase 378 Hyella caespitosa metabolites 262 hyellazole synthesis 262,413,414 hygrolidins 535 hygroline 638 hymenialdisine 276 hymenialdisine 3-bromo- 276 hymenialdisine debromo- 276 hymenin 637 Hymenocallis expansa alkaloids 306 Hymenocallis littoralis alkaloids 303 306 Hymenocallis pedalis alkaloids 306 Hymenocallis sonorensis alkaloids 306 Hymenocallis speciosa alkaloids 306 hymenocardine 75 Hymenomonas spp.hymenosulphate 459 hymenosulphate 459 Hymenoxys rushyi sesquiterpenes 156 Hymenoxys suhintegra sesquiterpenes 157 hyoscyamine biosynthesis 359 360 Hyoscyamus muticus hyoscyamine biosynthesis 360 vetispiradiene synthase 125 hypaconitine I9 1 hypecorinine 393 hypecorinine 8-0xo- 393 Hypecoum erectum spirobenzylisoquinolines 394 hypecoumine 394 Hypecoum leptocarpum protopines 393 secoberberines 393 spirobenzylisoquinolines,394 Hypecoum leptocarpus benzophenanthridines 396 leptocarpine 405 Subject index Hypecoum procumbens indaconitine 19 1 protopines 393 indicine 657 secoberberines 393 indipane 149 hyperectine 394,405 indipone structure 149 Hyperiella dilatata metabolites 288 indolactam-5 7-geranyl- 5 1 1 Hypnea musciformis metabolites 267 indole 91 Hypochoeris radicata indole 6-chlorooctahydro- iv(4) phytoalexin 95 indole alkaloids sesquiterpenes 152 156 isoprenoid 42 1 Hypomyces auruntius hypomycetin v(6) monoterpenoid 559-590 hypomycetin biosynthesis v(6) non-monoterpenoid 4 13-429 hyptinin 57 indole-3 -carboxaldehyde 1,7-dimethyl- 262 Hyptis mutabilis monoterpenoids 480 indolic phytoalexins biosynthesis 365-366 Hyptis spicigera monoterpenoids 480 indolizidine 167B 29,623 Hyptis suaveolens monoterpenoids 480 indolizidine 195B 26 625 Hyptis verticillata indolizidine 207A 29 cadina-4,10( 15)-dien-3-one 90 indolizidine 209B 623 lignans 57 indolizidine 209D 28,623 hyrtiomanzamine 415 indolizidine 223AB 27,28 624 Hyrtios erecta tryptamines 415 indolizidine 5-alkyl- alkaloids 623-624 Hyrtios spp.indolizidine 3-butyl-5-(pent-4-enyl)-,625 metabolites 279 indolizidine 3-cyano- 28 sesquiterpenoids 147 indolizidine 5-cyano- 29 Hyssopus officinalis indolizidine 3,5-dialkyl- 619 hydroxylating enzyme 120 alkaloids 624-625 mono terpen oi ds 480 indolizidine 5,8-dialkyl- 29 alkaloids 623-624 indolizidine 1,7-dihydroxy- 620 I indolizidine dihydroxy- 22-23 indolizidine l-hydroxy- 22 Ianthella basta metabolites 277 indolizidine 8-hydroxy- 22 ibogamine 578-579 indolizidine 5-hydroxymethyl- 25 ibophyllidine desethyl- synthesis 578 indolizidine 5-methoxycarbonyl- 29 icetexane 249 indolizidine 5-methoxycarbonylmethyl- 29 ICI 139603 535 indolizidine monohydroxy- 22-23 biosynthesis indolizidine pentahydroxy- 24 icosa-5,7,9,14,17-pentaenoate 344 indolizidine 1,2,6-trihydroxy- 23 biosynthesis indolizidine 1,2,7-trihydroxy- 620 icosa-5,8,11,14,17-pentaenoate 344 indolizidine alkaloids 21-41 619-636 acid 1 1 -hydroxy- hydroxylated 22-26 62M23 icosa-5,8,12,14-tetraenoic biosynthesis 344 steroidal 625-626 icosatetraenoic acid hydroxy- biosynthesis indolizidines 344 3,5-disubstituted 26-28 Idea leuconoe alkaloids 658 5,8-disubstituted 28-29 Ideopsis similis alkaloids 90 5-monosubstituted 28-29 Idiosperman australiense bisindole indolizidin-8-ol l -hydroxymethy1- alkaloids 427 synthesis 631 idiospermuline 427 indolizomycin 21 Igernella spp.metabolites 280 indolo[2,3-a]carbazole synthesis 425 igernellin 280 indolopyridocoline synthesis 420 iguesterin 16P-hydroxy- 673 indoloquinazolines 61 1 iguesterin,7a-hydroxy-7,8-dihydro-,673 indoloquinolizidine synthesis 560 iguesterol 3-indolylmethyl glucosinolate 88 7a-hydroxy-6-0~0-7,8-didehydro-,y-indomycinone 260 673 induced chemical defence 88-89 iguesteroquinone 673 inermosides 508 ILA-1 675 inflasaponins 672 Ilex argentina triterpenoids 675 infuscatrienol iii( 1) Ilex dumosa oleanane saponins 672 ingamine A 274 Ilexparaguariensis triterpenoids 675 ingenamine F 274 ilimaquinone ingenamines 274 structure 278 inostamycin biosynthesis 540 synthesis 147 insect antifeedants 89-90 Illicium minwanense sesquiterpenes 149 insects fatty acid synthetases 349 Illicium simonsii insularoside 508 neolignans 67 intebrimine 390 oligomeric lignans and neolignans 69 intebrinine 390 Illicium tashiroi sesquiterpenes 149 integerrimine 658 illudane 150- 15 1 determination 658 imerrubrine 400 integerrinecic acid lactone synthesis 655 imidazolidinones amino acid synthesis 208 interiorins 62 imino sugars synthesis vi(6) intermedine 83 immunomycin 536 Innula aspera sesquiterpenes 157 immunophilins molecular recognition vi(6) Inula crithmoides monoterpenoids 486 Imperata cylindrica lignans 54 inuloidin 149 imperialine 198 invertebrates fatty acid biosynthesis 349 imperialine P-N-oxide 200 a-ionol dihydro- 505 incisterol 17-methyl- 28 1 p-lonol glycoside dihydro- 505 synthesis 382 a-ionol-P-D-glucoside 3-OXO- synthesis 505 incrustasterols 28 1 V-ionone cyclisation 506 a-ionone 505 iso-6-cassine synthesis 644 reactions 506 Isochrysis galbana polyunsaturated fatty synthesis 146,506 acids 459 p-ionone 505 Isochrysis spp.fatty acids 166 reactions 506 isoclavulanic acid 3 14 p-ionone epoxy- reactions 506 isocleomblynol 666 y-ionone synthesis 506 isocomane 150 ionones 505-506 isocomene synthesis 150 P-ionylideneacetaldehyde,synthesis 506 isocorydine 397 Iostophane heterophylla sesquiterpenes 147 pharmacology 399 iphionane 151-153 isocorydine N-oxide 397 ipolamide 6P-hydroxy- 84 isoculmorin 460 ipomeamarone synthesis 145 isocurculigine 70 Ipomoeapolpha swainsonine 23 isodictamnine 11 Ipomoea spp.isodomesticine 397 swainsonine 23 Isodon eriocalyx diterpenoids 251 tropane alkaloids 649 Isodon gesneroides diterpenoids 25 1 ipsdienol 85 115 Isodon loxothyrae diterpenoids 25 1 synthesis 485 Zsodon macrocalyx diterpenoids 25 1 ipsenol 85 1 15 Zsodon spp.diterpenoids 250 synthesis 485 isoeburnamine 577 Ips paraconfusus isoedunol 282 ipsdienol 85 isoeudistomin U structure 290,424 monoterpenoids 115 isofagaridine synthesis 396 Ipspini isoferprenin synthesis 472 ipsdienol 85 isoflavonoids isopentenyl diphosphate monoterpenoids 115 isomerase 598 Ircinia felix metabolites 280 isogalcatin 46 Ircinia spinulosa metabolites 279 isoguanine 3,7-dimethyl- 278 Ircinia spp. metabolites 281 isoharzandione iii(3) irenolone 95 isohyperectine 394,405 iridanes 507-5 11 isoimermbrine 400 8-epi-iridodial 122 isoiridomyrmecin synthesis 507 iridoid glycosides 507 isojacpaniculine 52 iridoids 86,91 121 isokotanin A synthesis 473 biosynthesis 124 23-isokuroyurinidine 197 monoterpenoid 84 isolactaranes 90 150-1 5 1 iridolinarin-A 508 isolepidozene 158 iridolinarin-B 508 isoleucine isotope-labelled synthesis iridolinarin-C 508 205-2 1 2 Zridomyrex purpureus isolimonene 495 6-methyl-5-hepten-2-one 85 isolimonylborolane synthesis 489 iridomyrmecin synthesis 507,510 isolongifolene synthesis 150 iridomyrmecin isodehydro- synthesis 507 isolongifolenedione synthesis 150 8-epi-indotrial 122 a-isolupanine 33 34,629 irinotecan 584,586 a-isolupanine 5,6-dehydro- 34 Iris germanica triterpenoids 675 isomagnolone 67 irisgermanicals 675 isomandapamate 253,254,283 Iris pallida monoterpenoids 505 isomenthone 119,487 irniine 638 isomintlactone 492 Zryanthera grandis hybrid lignans 70 isomitraphylline isomerization 563 iryantherins 70 isonishiandaside 507 isaindigotadine iii(6) isonitin 246 isatin 455 .isonitramine 646 Isatis indigotica isaindigotadine iii(6) isoocobullenone 67 Ismene spp. alkaloids 306 isopaeonisuffral 494 i soacan thodoral synthesis 1 47 isoparthenin dihydro- synthesis 157 isoagathenediol 249 isoparvifolinone synthesis 148 isoalangiside 395 isopatriscabrol 508 isoalangiside 0-methyl- 395 isopaulitin structure 157 isoalloalantolactone 151 isopavines caryachine 391 isoandrosterone dehydro- phosphatides isopenicillin 323 synthesis 377 isopenicillin N biosynthesis 367 isoapiosylskimmine 465 isopenicillin N synthase 367 isobaisseoside 470 clavulanic acid biosynthesis 321,323 isobaisseoside-4’-p-coumarate, 470 isopentenol biosynthesis 591 isobatzelline C synthesis 419 isopentenyl diphosphate:dimeth ylall yl isoboldine 397 diphosphate isomerase 1 13 1 15 isoboonein 508 isopentenyl diphosphate isoborneol biosynthesis 112,478 mass spectra 498 iv( 1) oxidation 498 metabolic pools 599-600 isobromotopsentin 275 transport 600 isocalysterols 281 isopentenyl diphosphate isomerase 59 1-603 synthesis 382 activity isocamphanes 498-503 assay 594-595 isocamphanone 3-bromo- reactions 504 regulation 598-60 1,600-60 1 isocangorosinA iv(3) characterization 595-597 isocapnellane 150-151 compartmentation 599 isocaryophyllene synthesis 150 mechanism 597-598 1-22 Natural Products Reports 1997 multienzyme complexes 599 plants regulatory role 598-599 isopetasine synthesis 155 isopichierenol 676 isopichierenyl acetate 676 i sopicropodop h y llone 59 isopimaradiene 134 135 22-isopimpifolidine 198 isopinocampheols 495 isopinocamphone 120 isopiperitenone 7-hydroxy- 1 19 isoplatydesmine 11,606 isopodophyllotoxin 59 isopolygamain 57 isoprene 478 biosynthesis 113,591 isoprene synthase 1 13 isoprenoids biosynthesis 478,591-603,592-594 iv(5) metabolism 478 isopnstimerin 111 673 isopteleflorine 607 isopteleflorine 3’-0-acetyl- 606 607 isopteropodine isomerization 563 isopulegol 484 conversion into mintlactone and isomintlactone 492 isopulegone chloro- synthesis 492 isopulo’ upone 28 8 isoquinoline benzyl- alkaloids 388-390 isoquinoline 1-benzyltetrahydro- synthesis 394 isoquinoline bisbenzyl- 390 isoquinoline,6,7-dimethoxy-3,4-dihydro- reactions 387 isoquinoline,5-methoxymethyl-8-h ydrox y-tetrahydro- synthesis 398 isoquinoline naphthyl- 388 isoquinoline phenethyl- 404 isoquinoline tetrahydro- synthesis 387 isoquinoline alkaloids 387-388,387-411 isoquinolinium salts 1-aryl-3,4-dihydro- 388 3-isoreserpine 564 isoretroisosenine 658 isoretuline N-deacetyl- 568 isorhamnetin 3-(glucosyl-~l+6-galactoside)-7-glucoside 90 isorosmarinine 658 isosalicifoline 48 isoschizandrin 48 isoscopoletin 465 isosinococculine 400 isositsirikine 559 a-isosparteine 37,629 P-isosparteine 34,35,629 isotalatizidine 192 isotenulin synthesis from tenulin 157 isoterpinolene conversion into isolimonylborolane 489 isotetrandrine 390 isothalicberine 390 isothalicberine 7-0-demethyl- 390 isothalicberine 0-methyl- 390 isothujone reaction with sulfuryl chloride 505 isotrichodermol 127 isotrichodiol 126 isotrichotriol 127 isotrilobine 390 isotussilagine 657,658 isotylocrebrine 31,90,626 isotylocrebrine 3-demethyl- 3 1 isotylocrebrine 3-demethyl-l4a-hydroxy-, 31 isotylocrebrine N-oxide 3 1 isotylocrebrine N-oxide 3-demethyl-l&-hydroxy- 3 1 isotylocrebrine N-oxide 14a-hydroxy- 31 isovallesiachotamine synthesis 562 isovelleral 130 isovellerol 130 isoverticine 198 isoxeniatines 285 isozingiberene synthesis 149 Ithomiinae spp.alkaloids 658 Zuicium micranthum monoterpenoids 480 ivangulin synthesis 153 ivermectin 102 ixerenol 673 Zxeris chinensis saponins 673 Ixora chinensis fatty acids 164 J jacoline 658 jacpaniculine 52 Jacquemontiapaniculata lignans 52 Jacquinia macrocarpa pollination 9 1 Jamesoniella autumnalis diterpenoids 247 norlignans 70 jamesoniellideD 247 jamtinine 405 japondipsaponinEl 672 japonilure 85 Jasminium sambac monoterpenoids 478 480 jasmonic acid 88 165 biosynthesis 362 Jasonia glutinosa sesquiterpene 153 jaspamide synthesis 4 16 Jatropha cilliata coumarins 466,47 1 jatrorhizine biosynthesis 363 jatrorrhizine 392 javanicin Z 669 javanicin Z dihydro- 669 javanicin Z hemiacetal 669 jervine 202 joannesialactone iii(4) Joannesia princeps joannesialactone iii(4) Jodina rhombifolia fatty acids 164 jojoba wax hydrogenation 173 josamycin 104 jubanine-B N-desmethyl- 77 Juglans nigra monoterpenoids 480 jujubogenin 666 julandine synthesis 627 Jungermania infusca infuscatrienol iii( 1) Jungermannia hyalina diterpenoids 246 junicedranol 158 Juniperus chinensis diterpenoids 249 Juniperus communis fatty acids 165 monoterpenoids 480 sesquiterpenes 15 1 Juniperus convallium monoterpenoids 480 Juniperus oxycedrus monoterpenoids 480 sesquiterpenes 158 Juniperusphoenicea diterpenoids 247 Juniperus przewalskii monoterpenoids 480 Juniperus rigida monoterpenoids 480 Juniperus saltuaria monoterpenoids 480 Junonia ceonia oviposition stimulants 91 junosine 615 justicidin 57 justicidin B 59 justicidin E 44 juvabione 147 juziphine 389 K kadsulignans 60,62 Kadsura coccinea lignans 60 Kadsura japonica lignans 61 kadsurenone 67 kahweol 250 kalihinenes 254,279 Kallichroma tethys isoculmorin 460 kallolide B 283 kalopanaxsaponins 672 Kalopanar sepemlobus oleanane saponins 672 kapakahine B 274,424 karaferin 155 karaferinin 155 karahana ether 484 karahanenone 489 karasamine 12P-hydroxy- 193 karasamine 1 -epi- 12P-hydroxy- 193 karasamine-84-acetate 193 karasamine-84-acetate l2P-hydroxy- 193 cis-karenin 674 trans-karenin 674 KAS 111 Cuphea lanceolata 347 kauluamine 274,424 kaura-6,16-dienoic acid gibberellin biosynthesis 225 kaurane 16P 19-dihydroxy- hydroxylation 25 1 ent-kaurane 90 kauranes 16,17-dihydroxy- 250 16P-kauranoic acid 17-isovalerate 250 kaur- 16-en- 194 gibberellin biosynthesis 225 kaur- 15-ene 14-hydroxy- 25 1 kaur-Sene 17-hydroxy- 250 kaur- 16-ene synthetase 223 kaur-16-ene 250 conversion to GA,*-aldehyde 224-226 gibberellin biosynthesis from 222 kaur-16-ene 14-hydroxy- 25 1 kaur- l6-ene 3P-hydroxy- 250 kaur- 16-ene 15-oxo- biotransformations 25 1 kaurenes 135 136,250-25 1 kaurenoic acid ent-7-hydroxy- 136 kaur-16-en- 19-oic acid 250 conversion to GA, 224 kaur- 16-en- 19-oic acid 6a,7a-dihydroxy- gibberellin biosynthesis 225 kaur- 16-en- 19-oic acid 15a-hydroxy-, metabolism 236 kaur- 16-en- 19-oic acid 7a-hydroxy- conversion to GA3 224 kaur- 16-en- 19-oic acid 1 ~-oxo- biotransformations 25 1 kaurenoids 224 kaur- 16-en- 19-01 conversion to GA, 224 gibberellin biosynthesis 225 kaurenolide 7P 12a-dihydroxy- gibberellin biosynthesis 225 kaurenolide 7P-hydroxy- gibberellin biosynthesis 225 kaurenolides 224 kealiiquinone synthesis 275 kedarcidin 108 kelsoene iii(5) keramamide A synthesis 416 keramides 270 ketones oxazinyl2-fury1 synthesis 492 khellactone 467 khellactone-3’-~-~-glucopyranoside, 467 khelmarin D 473 Kigelia pinnata iridoids 508 kinamycin C v(3) kinamycins 445 biosynthesis 370 structure 532 kinginoside 508 8-epi-kingiside 123 8-epi-kingisidic acid 123 kingisidic acid 508 kirkine 304,305 Kirkpatrickia variolosa metabolites 277 Klebsiella pneumoniae cyclopeptide alkaloids 79 P-lactamases 310 polyketides 536 KM-01 153 Kochia scoparia oleanane saponins 672 Koelreuteria henryi lignans 56 koelreuterin- 1 56 kogol 153 kokusaginine 11 14,606,607 konbamide synthesis 416 kopsamine N-oxide 574 kopsaporine 573 Kopsia deverrei monoterpenoid indole alkaloids 560 565 568 Kopsia macrophylla monoterpenoid indole alkaloids 565,580 Kopsia pauciflora monoterpenoid indole alkaloids 573,574,577,580 Kopsia tenuis monoterpenoid indole alkaloids 580 Kopsia teoi monoterpenoid indole alkaloids 565,573,574 kopsidasinine 1 2-methoxy -10-demethox y- 573 kopsinaline N-methoxycarbonyl- 11,12-dimethoxy- 574 kopsinaline N-methoxycarbony 1-12-methoxy- 574 kopsinaline N-methoxycarbonyl- 11,12-methylenedioxy- 574 kopsinganol 573 kopsingine 573,574 kopsinginine 573 kopsinginol 573 kopsinine 574 kopsinine 17a-hydroxy-l4,15-didehydro-, 573 kopsinine N-methoxycarbonyl- 12-methoxy- 16,17-didehydro- 574 kopsinitarine D 574 kopsinitarines 574 kopsinol 573 kopsoffine 580 koreanol 52 korupensamines 0-trimethyl- 388 koryoginsenosides 666 Krameria grayi norlignans 70 Krameria paucifolia norlignans 70 kreysigine 404 kreysigine N-oxide 404 kudzusaponins 672 Kuehneromyces spp.sesquiterpenoids 146 kuehneromycin A 146 kumausyne synthesis 267 kumusine 278 kuroyurinidine 197 Kyllingia erecta diterpenoids 245 kynurenic acid 6-hydroxy- 11 Kyrtuthrix maculans maculalactone iii( 1) L L-67 I 776 146 labda-8( 17),13-diene 246 labdanes 245-246 iii(3) labd-7-ene-3P 15-diol 245 labd- 13-ene-8a,l5-diol 245 labdenediol 134 lacinileneC 128 lactacystin biosynthesis 371 P-lactamases 309-3 10 inhibitors detection 3 10-3 11 p-lactams 309 biosynthesis 366-368 lactarane 90,150-151 Lactarium vellereus sesquiterpenes 130 Subject index 1-23 Lactarius lignyotus diterpenoids 245 Lactarius spp.lactarufin A 90 sesquiterpenes 150 lactarufinA 90 lactic acid 0-p-fluoroaryl- 488 lactic acid phenyl- hyoscyamine biosynthesis 360 tropic acid biosynthesis 359 Lactobacillusplantarum isopentenyl diphosphate 1 13 lactones synthesis from hydroxy nitriles v(2) Lactucafloridana sesquiterpenes 130 156 Lactuca saligna sesquiterpenes 156 Lactuca virosa sesquiterpenes 15 1 156 lactucin 8-desocy- 130 lactucin 8-0-acetate 1 1 ,I 3-dihydro- 130 laevidiene 287 Lagarostrobos colensoi homoerythrina alkaloids 404 Lagerstroemia speciosa fatty acids I66 Laggerapterodonta sesquiterpenes 152 lagochilin 246 Lagochilus hirsutissimus diterpenoids 246 lagochirzin 246 Lagoecia cuminoides monoterpenoids 480 laingolide 454 lamellarins 274 Laminaria spp.fatty acids 166 lanceomigine 565 landanomycin 5,6-anhydro- biosynthesis 532 landanomycin A biosynthesis 532 languidulane 247 lanigeraol 249 Lanius ludovicianus alkaloids 658 lanostane triterpenoids 662-665 lanosterol 663 synthesis 66 1 Lantana camara oleanane triterpenoids 67 1 triterpenoids 674 lantanoside 509 lanuginosine 399 lapidilectineB 580 lappaconitine N-deacetyl- 195 lappaconitine N-oxide NMR 195 lariciresinol 45,52 synthesis 54 lariciresinol 5-hydroxy- 52 lariciresinol 7-hydroxy- 52 Larrea tridentata lignans 44,46 57 Laserpitium latifolium sesquiterpenes 156 Lasioderma serricorne fatty acid biosynthesis 350 lasiol synthesis 485 Lasius meridionalis monoterpenoids 485 lasubine 32 Lathraea squamaria iridoids 508 lathyrine biosynthesis iv( 1) Lathyrus tingitanus lathyrine iv( 1) Latrunculia apicalis metabolites 274 Latrunculia spp.discorhabdin B biosynthesis 37 1 laucubin 10-0-acetyl- 508 laudanosoline structure 392 laukarlaol 249,267 laurane 148 laurediol 267 Laurella sempervirens bisbenzylisoquinolines 390 Laurencia calliclada squalene triterpenoids 66 1 Laurencia karlae benkarlaol iii( 1) diterpenoids 249 sesquiterpenoids 146 Laurencia majuscula metabolites 267 1-24 Natural Products Reports 1997 sesquiterpenes 148 sesquiterpenoids 148 Laurencia obtusa sesquiterpenoids 148 Laurencia omaezakiana metabolites 267 squalene triterpenoids 661 Laurencia paniculata metabolites 267 Laurencia spectabilis metabolites 266 Laurencia spp.metabolites 267 laurencin synthesis 267 laurencione 266 laurene synthesis 148 laureolol 0-methyl- 662 Laurilia tsugicola sesquiterpenes 150 laurolitsine 397 laurotetanine N-methyl- 397 laurotetantine 397 Lavandula luisieri a-neerodol 89 lavandulol 485 lavanduquinocin 4 13 laxoflorins 25 1 Ledum groenlandicum monoterpenoids 480 Ledum palustre monoterpenoids 480 Leiopathes spp.fatty acids 165 lennoxamine synthesis 394,395 lenticellarine 404 lentiginosine 22,620 synthesis 619 Leonotis ocymifolia diterpenoids 246 Leonurus persicus diterpenoids 245 leopersin A 245 lepadins 289 607,610 Lepechinafloribunda monoterpenoids 480 lepidimoide 92 leptocarpin structure 15 1 leptocarpine 393,405 Leptochloa dubia diterpenes 92 leptodactylone 465 leptosins 261,460 Leptosphaeria obiones obionin A 460 Leptosphaeria oraemaris leptosphaerin 460 leptospherodione 460 Leptosphaeria spp. leptosins 460 metabolites 261 leptosphaerin 460 leptospherodione 460 Leptothoracini pyrrolidine alkaloids 638 Lepus europaeus phenolics 87 Lepus timidus phenolics 87 leroyine 14-0-acetate 193 Lesquerella fendleri fatty acids 166 178 lesquerolic acid 178 estolides synthesis 178 lettucenin A 95 leucascandolideA 462 Leucascandra vaveolata secondary metabolites 462 Leucetta spp.metabolites 275 leucine isotope-labelled synthesis 205-2 12 leucine 53’-dihydroxy- isotope-labelled synthesis 210 leucine 5-flUOrO- isotope-labelled synthesis 210 leucine 5,5,5-trifluoro- synthesis 210 leucodin dehydro- 157 Leucojium autumnale alkaloids 306 leucomycin biosynthesis 535 leucophyllone 666 leucotamine 304,305 leucotamine 0-methyl- 304 305 leucoxylonine 397 leukotrienes 165 biosynthesis 35 1 Leuzea carthamoides ecdysteroids 89 LG-1 294 LG-2 294 Libocedrus plumosa lignans 44 lignans 43-74,4662 analysis 43-44 biological activity 44-45 biosynthesis 4546,433 hybrid 70 identification 43-44 metabolism 45-46 oligomeric 69 Lignincola laevis sphingosines 460 ligstral 508 ligstroside 123 Ligularia nelumbifolia sesquiterpenes 155 Ligularia przewalskii sesquiterpenes 155 Ligularia sagitta sesquiterpenes 155 Ligularia veitchiana oleanane triterpenoids 67 1 Ligularia veitchiania ligulaverinA iv( 1) ligulaverinA iv( 1) Ligusticum sinensis sesquiterpenes 147 ligustilone 147 Ligustrurnpenduncalare monoterpenoids 47 8 liguveitol 67 1 liguveitosideA 67 1 lilacoside 123 Lilium elegans brassinosteroids 4 Lilium longiflorum brassinosteroids 1,3,4 8 limacine 390 limacine 2’P-N-oxide 390 limacusine 2’P-N-oxide 390 limeolide 146 Lirneum pterocarpum sesqui terpenoids 146 limmettin 465 Limnophila rugosa oleanane triterpenoids 669 limonene 89,91,487,488 biosynthesis 116,486 reaction with acids 488 limonene epoxy- 489 limonene synthase 116 Limonia acidissima fatty acids 165 limonidilactone structure 245 limonin 89 linalool 85,91,482 analysis 483 biosynthesis 115 linalool dihydro- 484 linalool dihydroxy- 478 linalool 6,7-epoxy- biosynthesis 1 15 linalool oxide 91 linalool synthase 115,482 linalyl acetate 483 linalyl O-a-L-arabinopyranosyl- P-D-glucopyranoside 478 linalyl diphosphate biosynthesis 115 linalyl glucoside 478 linamarin biosynthesis 366 linaresine 39 1 linaresine dihydro- 391 Linaria dalmatica iridoids 508 Linaria genistifolia iridoids 508 Linaria japonica iridoids 508 monoterpenoids 482 505 Linaria peloponnesiaca iridoids 508 Linaria saxatilis diterpenoids 246 Linaria spp.iridoids 508 linaride 123 linarioloside 508 lindelane 151-153 Lindera benzoin monoterpenoids 480 Linderniapyxidaria oleanane saponins 672 linderniosides 672 lineatin synthesis 477 Lingusticum elatum coumarins 466,467 Linnophila heterophylla oleanane triterpenoids 67 1 linoleic acid biosynthesis 339,347,351 C-isotope labelled synthesis 173 linoleic acid 13-hydroperoxy- 174 linoleic acid hydroperoxide detection 173 linoleic acids 1I-substituted synthesis 167 a-linolenic acid biosynthesis 35 1 linolenic acid biosynthesis 347 deuterium-labelled synthesis 172 synthesis 167 y-linolenic acid 164 178 biosynthesis 339 y-linolenic acid 9-hydroperoxy- 174 Linum spp.lignans 43 liovil 52 lipases 483 microwave irradiation vi( 1) lipoaconitine 192 lipoic acid biosynthesis 335 lipopurealins 276 lipoxygenases 178 mechanism v(4) Lippia adoensis monoterpenoids 480 Lippia alba monoterpenoids 480 Lippia integrifolia monoterpenoids 480 sesquiterpenes 15 1 Lippia junelliana monoterpenoids 480 Lippia micromera monoterpenoids 480 Lippiapolystacha monoterpenoids 480 Lippia turbinata monoterpenoids 480 Liptogorgiapiccola fatty acids 164 liriodendrin 44 liriodenine 399 physiological effects 399 lissoclinamide synthesis 290 Lissoclinum fragile bisindole alkaloids 424 metabolites 290 Lissoclinum patella metabolites 290 Lissoclinum vareau metabolites 290 Lissoclinum voeltzkowi lissoketal iii(2) lissoketal iii(2) litcubine 39 1 392 litcubinine 391 392 litebamine 398,399 lithium menthenyl- synthesis 492 Lithothamnion calcareum fatty acids 165 Lithothamnion corallioides fatty acid biosynthesis 344 fatty acids 165 Litsea cubeba benzopyrrocolines 39 I monoterpenoids 480 Litsea garciae aporphines 397 benzylisoquinolines 389 littorine biosynthesis 360 tropic acid biosynthesis 359 loba-8,10,15,17-tetraen- 19-al 13-hydroxy- 285 loba-8,10,13( 15),16-tetraene 18-methoxy- 285 loba-8,10,16-trien-18-ol 13,15-epoxy- 285 Lobophytum hirsutum metabolites 285 Lobophytum pauciflorum diterpenoids 253 metabolites 285 Lobophytum spp.diterpenoids 253 lochneram 565 lochnerine 565 lochnerine 18-hydroxy- 565 loganic acid 7-O-benzoyl- 508 8-epi-loganic acid 7-O-p-hydroxybenzoyl- 509 loganin hydroxy- 5 10 loganin 7-keto- 123 8-epi-loganin synthesis 5 11 longifolane 149-150 longipinane 14% 150 longirabdolideD 251 Subject index Longitarsus jacobaeae pyrrolizidine alkaloids 87 longithorones iii(5) longoamide 278 Lonicera gracilipes coumarins 466,470 Lonicera morrowii iridoids 508 Lophocolea bidentata sesquiterpenes 15 1 lotusanine-A 77 lotusanine-B 79 lotusine-B 78 lotusine-C 78 lotusine-E 77 lotusine-F 76 lovenone 288,664 loxothyrin A 251 lucinone 152 lucyosides 672 ludaconitine 191 Luehdorj?a japonica flavonoids 90 Lufa cylindrica oleanane saponins 672 LufSariella spp.metabolites 280 luffariolide 280 Luidia clathrata metabolites 294 Luidia ludwigi metabolites 294 lukaniol A 290 lumazine 294 P-lumicornigerine 404 P-lumidemecolcine 404 lunacridine 12 lunacrinol 605,606 Lunaria annua fatty acids 177 lundurine B NMR 580 lupane triterpenoids 669 lupanine 33 34,35 629 lupanine dehydro- 34 lupanine 5,6-dehydro- 34,35,629,630 NMR 35 lupanine 3-hydroxy- 34 lupanine 3P-hydroxy- 34 lupanine 4-hydroxy- 629 lupanine 6a-hydroxy- 629,630 lupanine 13-hydroxy- 33,35,629 lupanine 13a-hydroxy- 629 lupanine 15P-hydroxy-17-0~0- 34 35 lupanine 13-oxo- conformation 63 I lupanine 17-oxo- 34,35 629 lupanine 13a-tigloyloxy- 35 lup-20( 29)-ene-23,28-dioic acid 3P-hydroxy- 669 lup-20( 29)-ene-24,28-dioic acid 3P-hydroxy- 669 lup-20(29)-ene-3P,23-diol,669 lup-20(29)-en-28-oic acid 3a,23-dihydroxy- 669 lup-20(29)-en-28-oic acid 3P,23-dihydroxy- 669 lupeol caffeate 669 lupinine 21,33 619 synthesis 36 lupinine alkaloids 32-37 628-633 analysis 628 chemical ecology 628430 chemotaxonomy 628-630 detection 628 629 isolation 629 occurrence 628 spectroscopy 630-63 1 structures 630-63 1 synthesis 63 1 Lupinus albus alkaloids 33,34 35,629,630 famesyl diphosphate synthase 114 geranylgeranyl diphosphate synthase 1 15 Lupinus angustifolius alkaloids 33,34 Lupinus arcticus alkaloids 34,35 Lupinus argenteus alkaloids 33,34 Lupinus bracteatus alkaloids 33 Lupinus hirsutus alkaloids 34,35 Lupinusparaguariensis alkaloids 33 Lupinuspolyphyllus alkaloids 33,34 35 Lupinus pusillus alkaloids 629 Lupinus spp.alkaloids 628 lusitanine 629 lusitanine dihydro- mass spectrometry 630 lycaconitine methyl- 193 pharmacology 196 synthesis 195-196 lycactonine methyl- 194 Lycium chinense tryptamines 416 lyciumin A conformation analysis 416 lycoconitine methyl- pharmacology 196 lycoctonine 192 Lycogala epidendrum pyrrole alkaloids 638 lycoglic acid dimethyl esters 424 lycopanerols iii(4) Lycopersicon esculente sesquiterpenes 133 Lycopersicon esculentum alkaloids 201 brassinosteroids 5 gibberellin biosynthesis 222 induced chemical defence 88 Lycopersicon hirsutum terpenoids 86 Lycopersiconpennellii sugar esters 91 Lycopersiconpimpinellifolium, alkaloids 198 Lycopodium spp.piperidine alkaloids 646 lycopsamine 83 lycoramine 304,306 lycoramine epi-N-demethyl- 304 306 y-lycorane synthesis 307 lycorenine 304,306 lycorenine 0-methyl- 304,306 lycorine 303,304,305,306,307 Lycoris sanguinea alkaloids 306 lyfoline 627 10-epi-lyfoline 627 Lygos raetam alkaloids 629,630,63 1 lyngbyacarbonate 262 Lyngbya majuscula metabolites 262 Lyngbya spp. secondary metabolites 454 lysergene 42 1 Lysicarpus angustifolius monoterpenoids 480 lysine biosynthesis v(6) isotope-labelled synthesis 215-217 lysolipin X biosynthesis 532 Lythraceae alkaloids 21 32,619,627 lythridine 627 M Maackia amunensis hybrid lignans 70 Maackia amurensis alkaloids 36 maackoline 70 maaliane 157 macarpine synthesis 396 machicendiol synthesis 70 machilin A 44 Machilus japonica lignans 52 macnabin 149 macrocalyxins 25 1 macrocarpamine 566 synthesis 580 macrolide antibiotics 104-106 macrolides side effects 106 macrophomic acid iv(2) macrosalhine methine anhydro- 566 macroside-A hydro- 508 macroside-B hydro- 508 maculalactone iii( 1) maculine 606 maculosidine 606 Maerua crassifolia sesquiterpenoids 145 magellanine 646 Magfnolia biondii lignans 52 magnoflorine 397,398 magnograndiolide I57 Magnolia biondii monoterpenoids 480 neolignans 67 Magnolia fargesii lignans 54 Magnolia grandiBora sesquiterpenes 15 1 Magnolia kobus aporphines 397 Magnolia obovata monoterpenoids 480 Magnolia oficinalis monoterpenoids 500 Magnolia soulangeana aporphines 397 Magnolia speciosa aporphines 397 Magnolia virginiana neolignans 43 magnoline pharmacology 399 magnolol monoterpenyl- synthesis 70,500 magnolol synthesis 67 magnoshinin 59 maitotoxin 263,457,537 majapol A 148 majapolane 147-148 majapol B 148 majapol C 148 majapol D 148 majapolene A 148 majapolene B 148 majapolenes 267 majapolols 267 majapolone 148,267 Majorana hortensis triterpenoids 675 Majorana syriaca essential oils 478 makaluvamine A synthesis 419 makaluvamines 274 makaluvic acids iv(2) makienones 262 malabaricanes 67 5 malagashanine 568 malagashanine 12-hydroxy- 568 malaysiastatin 274 malaysic acid 165 malekulatine 390 malonyl CoA ACP transacylase fatty acid biosynthesis 347 Malus domestica monoterpenoids 505 malyngamides 262 mamanine 13P-hydroxy- 36 Mamestra brassicae fatty acid biosynthesis 35 1 manadic acids 270 mandelate racemase v(3) Mangifera indica fatty acids 163 mannojirimycin 645 mannojirimycin deoxy- 645 mannonolactam 645 ent-manool 13-O-fI-xylopyranosyl- 245 manoyl oxide hydroxy- 246 manoyl oxide 16-hydroxy- 245 mansonine 304,306 mansonine N-demethyl- 304,306 mansumbin- 13( 17)-en-28-oic acid 3fI,16-dihydroxy- 666 manumycins 445 biosynthesis 445446,446 manzamenones 270 manzamine L stereostructure 420 manzamine X 274 mappicine synthesis 587 Maprounea africana saponins 672 Maprounea membrancea saponins 672 Marah macrocarpus gibberellin biosynthesis 222 226 marasmane 90 150-151 maravuic acid 246 marcellomycin 100 maremycins 260,416 marginolactones biosynthesis 536 marinactam 455 marine microorganisms secondary metabolites 453464 marine natural products 259-302 marinone 453 marinone debromo- 453 marinostatins 455 maritidine 8-O-demethyl- 303 304 Marjarana hortensis monoterpenoids 480 marmesin 95 marmesin-2 ’-@p-D-ghcopyranoside 2’-hydroxy- 467 marmesinine 467 marmin 465 marmin chloro- 465 marmin 7’-O-methyl- 465 marminal 465 marmbinone A 245 marmbinone B 245 Marrubium astracanicum diterpenoids 245 Marrubium polydon diterpenoids 245 marshdine 18 marshmine 18 615 matairesinol 43,44,45,48 matairesinol dimethyl ether NMR 48 matopensine 579 matrine 34,629 matrine alkaloids 32-37,628-633 analysis 628 chemical ecoloty 628-630 chemotaxonomy 628-630 detection 628 629 isolation 629 occurrence 628 spectroscopy 630-631 structures 63043 1 synthesis 631 matrine N-oxide 34 mauritines 79 79430,416 maytansine 440 maytansinoids 440 biosynthesis 445 maytenfolone 673 Maytenus blepharodes saponins 673 Maytenus boaria sesquiterpenes 153 Maytenus caniariensis saponins 673 Maytenus chuchuhuasca saponins 673 Maytenus diversifolia saponins 673 Maytenus emarginata pyndine alkaloids 639 Maytenus ilicifolia cangorosins iv(3) Maytenus spp.saponins 673 mayurone epoxide 148 mazusaponins 672,675 Mazus miquelii oleanane saponins 672 triterpenoids 675 MCF-7 tumour cells vii(3) MDL28574 26 Mechanitispolymnia tropane alkaloids 84 Meconopsis quintuplinerva berberines 392 mediterraneol B 265 mediterraneols tetramethyl- 265 Meerw ein-Ponndorf-Verley reduction steroid carbonyl compounds 375 megacerotonic acid 68 megallaninone 646 megaphone acetate 5-demethoxy- 67 Megaponera foetens N,N-dimethyluracil 85 megastigm-7-en-9-one 3-hydroxy- 145 Melaleuca alternifolia monoterpenoids 487 Melaleuca howeana monoterpenoids 480 Melaleuca leucadendron monoterpenoids 480 Melaleuca parvijlora monoterpenoids 480 melampolides structures 15 1 Melanoplus sanguinipes fatty acids 166 Melia azedarach azedarachin C 89 triterpenoids 669 meliacarpinin 669 melianinone 668 Melia toosendan triterpenoids 668 meliavolen 668 meliavolin 668 meliavolkenin 668 Melia volkensii triterpenoids 668 meliavolkensins 668 meliavolkin 668 Melicope semecarpifolia furoquinoline alkaloids 608 quinoline alkaloids 606 melilotosides 672 Melilotus albus oleanane saponins 672 Melilotus messanensis triterpenes 92 melinacidins 460 Melissa oficinalis monoterpenoids 478 mellein biosynthesis 553 mellein 6-hydroxy- 55 1 mellein 6-methoxy- 55 1 Melochia corchorifolia cyclopeptide alkaloids 80 melofoline 77 melonovine-A 77 meloxinenone 147 menaquinones 592 biosynthesis v(6) menaquinones dihydro- biosynthesis iv(5) Mennoniellaspp.sesquiterpenoids 146 Mentha arvensis monoterpenoids 477,486 p-menthane 1,2:4,8-diepoxy- 489 menthanes 486-494 Mentha piperita isopenten yl dipho spha te 599 monoterpenoids 119,487 Mentha pulegium dimethylallyl diphosphate 600 Mentha spicata monoterpenoids 116,486 Mentha spp. biosynthesis 478 monoterpenes biosynthesis 124 o-menthenes 488 menthofurans 92 synthesis 494 menthol 119,486,487,489,495 biosynthesis iv(5) production 489 menthone 92,119,486,487,489 deprotonation 492 reduction 492 menthone toluene-p-sulfonylhydrazone synthesis 492 menthyl acrylate Diels-Alder reaction 490 49 1 menthyl acrylate 8-phenyl- Diels-Alder reaction 491 menthyl arylacetate 8-phenyl- silyl acetals 49 1 menthyl esters 489 p-menthyl alcohols 488 menthyl phosphorodichloridite synthesis 490 mentzefoliol 508 mentzefoliol glucosyl- 508 Mentzelia cordifolia iridoids 508 mequinine 392 Merendera robus ta phenethylisoquinolines 404 proaporphines 397 merobustine 404 merobustinine 404 meroditerpenes 265 meromycolic acid biosynthesis 341 meroterpenoids biosynthesis 59 1 mersingines 574 mesaconitine 19 1 mescaline demethylation 387 mescengricin iv(4) messagenin 92 Metarhizium anisopliae indolizidine alkaloids 62042 1 swainsonine 23 methane monoxygenase active metal centre v(1) Methanobacterium thermoautotrophicum fatty acid biosynthesis 343 geranylgeranyl diphosphate synthase 1 15 lipid biosynthesis enzymes 115 1-24 Natural Products Reports 2997 Methanobacterium thermoformicicum gerany lgerany 1diphosphate synthase 115 9,lO-methanooctadecanoicacid biosynthesis 343 10,ll -methanotetradec- 10-enoic acid biosynthesis 349 methicillin 309 methionine biosynthesis v(6) isotope-labelled synthesis 21 2-214 methionine methyl- isotope-labelled synthesis 2 14 methyl 15-0-acetylisocupressate 246 methyl anthranilate 85 methyl 3-benzoylkatonoate 67 1 methyl 3-epi-betulinate 669 methyl bromide 458-459 methylbutanoyl CoA fatty acid biosynthesis 336 methyl cholate conversion into 3P-epimer 379 methyl dimorphecolate 165 synthesis 168 methyl hydroxybenzoate 84 methyl 3a-hydroxyolean- 18-en-28-oate 67 1 methyl linoleate autoxidation 173 deuterium-labelled synthesis 172 oxidation 174 methylmalonyl CoA mutase v(4) methyl 5,6-methylene-5-tetraicosenoate biosynthesis 341 methyl nicotinate 85 Methy lobacterium fujisawaense isopenteny1 diphosphate 1 13 methyl omphalate 148 methyl piperitol synthesis 56 methyl pluviatilol synthesis 56 2-methylpropanoyl ACP fatty acid biosynthesis 339 2-methylpropanoyl CoA fatty acid biosynthesis 336 methyl salicylate 9 1 methyl selenalaurate synthesis 17 1 methyl sterculate synthesis 169 methyl sterculate 2-hydroxy- synthesis 169 methyl telluralaurate synthesis 17 1 N-methyltransferase 366 methyl xanthoxylol synthesis 56 metopon pharmacology 404 Metrodoreaflavida coumarins 466,47 1 Metrodorea nigra quinoline alkaloids 606 m ev alon ate 5-di ph 0sp hate decarbox y1ase 113 mevalonate kinase 113 mevalonate 5-phosphate biosynthesis 112 mevalonic acid biosynthesis 1 1 1-1 12 conversion to ent-kaur-16-ene 222-224 gibberellin biosynthesis 222 mevinolin biosynthesis 546 mexoticin stereochemistry 468 michampanolide 157 Michelia champaca sesquiterpenes 157 Michelia nilagirira sesquiterpenes 15 1 microalgae green secondary metabolites 459 red secondary metabolites 459 Microbispora spp.fatty acids 167 micrococcin biosynthesis 370 microcolins 454 Microcos philippinensis piperidine alkaloids 644 Microcystis aeruginosa tryptamines 4 16 Micromeria fruticosa monoterpenoids 480 487 Micromonospora chersina polyketides 54 1 Micromonospora echinospora calicheamicins 103 Subject index Micromonospora griseorubida pol yketides biosynthesis 478 535 1,5-dienes reactions 478 Micromonospora spp.monoterpenyl6-O-P-~-apiofuranosy1-polyketides 536 P-D-glucopyranosides 477 secondary metabolites 462 Montanoa kanuinskii sesquiterpenes 150 microorganisms marine natural products Morina longifolia triterpenoids 674 259-263 morinoursolic acid A 675 micropine synthesis 644 morinoursolic acid B 674 Microsporum gypseum turpentine oil 478 morphinan alkaloids biosynthesis 362 Microtus aquestis phenolics 87 morphine Microtus ochrogaster tannins 87 analgesic effects 403 microviridins 4 16 biosynthesis 362 midecamycin 104 estimation 403 mifepristone synthesis 373 morphine 3-0-ethyl- pharmacology 404 Migdolus fryanus N-methylbutanoyl morphine 1O-oxo-6~-thiodihydrodeoxy- 2-methylbutylamine 85 pharmacology 402 Mikania ypacarayensis sesquiterpenes 15 1 morphine 7-phenyl- 402 milbemycins 537 morphine alkaloids 400-404 milonine 400 morphine 3-glucuronide mimosamycin 462 estimation 403 Mimosa pigra saponins 672 pharmacology 403 mimugenone 67 1 morphine 6-glucuronide mimusopgenone 67 1 estimation 403 mimusopin 672 pharmacology 404 Mimusops elengi morphine-6-glucuronide 3-0-ethyl- lupane triterpenoids 669 pharmacology 402 oleanane saponins 672 morphine-6-sulfate 3-0-acetyl- oleanane triterpenoids 67 1 pharmacology 403 mimusopsin 672 morphine 6-0-acetyl- pharmacology 403 mintlactone synthesis 492 morphine 6P-aminodeoxy- pharmacology Mintostachys andina monoterpenoids 480 402 minwanensin 149 morphine 6P-amino- 14-hydroxy- miocamycin 104 pharmacology 402 Mirabilis jalaba ocimene 9 1 morphine dihydro- pharmacology 403 miriamide 90 morphinone biosynthesis 362 miriamide 5-dehydroxy- 90 morphinone,4,5deoxy- 14-hydroxydihydro- miriamide 5-glucoside 90 pharmacology 402 misramine 397 morphinone 3-deoxy- 14-methoxy- mithramycin 101 102 N-phenethylnordihydro- mitomycin K synthesis 414 pharmacology 402 mitomycins 445 morphinone dihydro- pharmacology 404 biosynthesis 440 441 morphinone 14-hydroxydihydro- mitomysin 6-demethyl- synthesis 41 5 pharmacology 402 mitomysin 6-demethyl-6-halo- synthesis morphinone 5-methyldihydro- 415 pharmacology 404 mitosene azido- oxidation 414 morphinone 7-phenyl- 402 mitragynine pseudoindoxyl stereochemistry Morus spp.sanggenons iii(5) 563 mossambine synthesis 571 mitraphylline isomerization 563 motuporin 270 mitsugashiwalactone synthesis 5 10 muamvatin 553 Mitsunobu acylation cholestan alcohols 375 Mucor miehei lipases 483 MM19290 314 Mucor mucedo HMG-CoA reductase 1 12 modhephane 150 Mucorplumbeus diterpenoids 25 1 modhephene synthesis 150 mucronine-D 0-desmethyl- 77 moenomycin A 107 mucronines 79,7940 moenomycins structure-activity mulgediifoline 657,658 relationship 107 mullilam diol 486 molecular recognition vi(6) multiflor-7-ene 674 molluscs metabolites 286-288 multiflor-9( 1 1)-ene 674 molokinenone 279 multiflorine 33 34 35 momordins,2’-O-P-~-glucopyranosyl-, 672 multiflorine I1,12-seco-12,13-didehydro- monabactams 3 1 1 34,36 Monanchora arbuscula metabolites 274 munzianine 193 monankarins structures 472 munzinanone 193 Monascus anka coumarins 466,472 murayaquinone biosynthesis v(3) monensin 523,528 Muricella spp.metabolites 285 monensin A 540 muridienin iv(2) monocerin 93 Murraya euchrestifolia indole alkaloids 4 13 Monoclea forsteri fatty acids 165 Murraya exotica monocrotaline 659 coumarins 466,467 monocyclofamesane 145-147 triterpenoids 663 monomorine 27,625 Murraya koenigii monomorine I 26 monoterpenoids 480 monoterpene cyclases 119,478 sesquiterpenes 153 monoterpene dienes reaction with ozone murrayamines structures 413 47 8 murrayanolide 286 monoterpenes biosynthesis 124 Murrayapaniculata coumarins 465,466 monoterpene synthetases 478 467,468 monoterpenoids 92 115-124,477-522 Murrayellapericlados fatty acids 165 analysis 477 Musa acuminata phytoalexins 95 musanolones 95 Musca domestica fatty acid biosynthesis 350 muscone synthesis 500 musigadial 12a-acetal 9-deoxy- 146 Mussaenda pubescens oleanane saponins 672 triterpenoids 664,675 mussaendoside F 664 mussaendoside R 675 mussaendoside S 672 mussaenoside synthesis 5 1 1 mutactin 528 mutangin 89 mutifidene synthesis 264 muurolene 86 muzigaal 146 muzigadial 9-epideoxy- 146 muzigadial 12P-acetal,9-deoxy- 146 Mycale laxissima fatty acids 166 Mycale rotalis metabolites 267 mycalolides 28 1 mycobacteria fatty acid biosynthesis 335 336 Mycobacteria spp.fatty acid biosynthesis 339-341 Mycobacterium leprae fatty acid biosynthesis 339 Mycobacterium smegmatis fatty acid biosynthesis 339 Mycobacterium tuberculosis fatty acid biosynthesis 339 340 fatty acids 167 mycocerosic acids biosynthesis 340 mycocerosic acid synthase fatty acid biosynthesis 340 mycolic acids 340 biosynthesis 167 mycoside B 340 mycosporin-gly 28 1 mycotrienins biosynthesis 433 Mylia nuda nudenoic acid iii(2) Mylia taylorii sesquiterpenes 157 myoporone synthesis 145 myrcene 85,478,482 epoxidation 483 myrcene dihydro- ozonolysis 484 myrianthine-B 77 Myrianthus liberecus oleanane triterpenoids 671 myriantine-C N-desmethyl- 77 Myrmicaria eumenoides indolizidine alkaloids 26 mymicarin 237A 26 mymicarin 237B 26 Myrmica rubra steroidal alkaloids 84 Myrsine australis saponins 672 myrsinol 253 myrtenal 4-hydroxy- 494 myrtenol 120,494 Myrtillocactus geometrizans monoterpenoids 504 myrtine 21,32,619 myrtopsine 7,8-dimethoxy- 1 1 Mytilus edilis metabolites 288 myxobacteria polyketides 524 Myxococcus fulvus isopentenyl diphosphate 113 Myxococcus spp.fatty acid biosynthesis 336 Myxococcus virescens polyketides 545 quinoline alkaloids 607,609 myxol 260 rnyxovirescen A I 545 myxovirescin biosynthesis 449 N naamidines 274 nagilactones 246 glycosides 249 nakijinol 146,278 nakijiquinone C 147 nakijiquinones 278 nakitriol 262 nalbufine pharmacology 404 nalbuphine pharmacology 402 nalmefene pharmacology 404 naloxonazine pharmacology 404 naloxone pharmacokinetics 403 naltrexamine 6-N-cinnamoyl- pharmacology 404 naltrexamine,6-N-(p-nitrocinnamoy1)- pharmacology 404 naltrexone 7-benzylidene- pharmacology 402 naltrexone methyl- pharmacology 404 naltrexone pharmacology 404 naltrindole pharmacology 402,404 nanaomycin 526 nandigerine 397 Nannochloropsis spp.eicosapentaenoic acid 459 nantenine 0x0- 399 nantenine pharmacology 399 12-epi-napelline 192 12-epi-napelline dehydro- 192 naphthalene aryl- 5&60 naphthalene 4-hydroxyaryl- lignans 45 naphthol androst-4-en-3,17-dione complexes 374 naphthomycin 445 biosynthesis 441 naphthomycin A biosynthesis 543 naphthoquinone 84 naphthoquinones 249 naphthoquinones 6-alkyl- 84 narciclasine 303 304 306 narciclasine 7-deoxy- 304 306 narciclasine 7-deoxy-trans-dihydro- 304 306 narcissidine 304 306 narcissidine 3-0-acetyl- 304 306 narcissidine N-oxide 3-0-acetyl- 304 306 Narcissus primigenius alkaloids 303 Narcissus pseudonarcissus alkaloids 303 306 Narcissus tortuosus alkaloids 306 nardosinane 158 nardosin-1(10),11(13)-diene 12-hydroxy- 28 1 naringenin 93,95 narwedine 304,305,306 Natronobacteriumpharaonis farnesylgeranyl diphosphate synthase 115 natsucitrines 615 Nauclea idierrichii triterpenoids 675 Nauclea latifolia monoterpenoid indole alkaloids 560 Nauclea officinalis monoterpenoid indole alkaloids 560 nauclefine synthesis 41 6 naucleidinal synthesis 560 naucletine synthesis 416 Navanax inermis metabolites 288 navelbine NMR 580 Navicula spp.eicosapentaenoic acid 459 necic acids synthesis 655-657 necines synthesis 653-655 Necrodes surinamensis a-neerodol 89 Nectandra ramonensis aporphines 397 Nectandra salicifolia aporphines 397 benzylisoquinolines 389 bisbenzylisoquinolines 390 morphine alkaloids 400 proaporphines 397 neeflene 668 a-neerodol 89 nemedectins 537 nemorensic acid 657 nemorensine synthesis 656 neoacrimarine-C 615 neoacrimarine-E 18 neoalangiside 395 neoalangiside 0-demethyl- 395 Neoalsomitra integrifoliola triterpenoids 666 neoalsosides 666 neoambrosin synthesis 157 neoangustifolin iii(4) neoarctin B 69 neocarzinostatin 102 104 biosynthesis 541 neo-clerodanes 246 4( 18)-neocleroden- 15-oic acid 2a,3P-dihydroxy- 246 neocryptolepine 414,423 P-neodolabellenol 283 neohalicholactone 270 neoipecoside 395 neolalsogenins 666 neolignans 43-74,62-68 analysis 43-44 biological activity 44-45 biosynthesis 45-46 identification 4344 metabolism 4546 oligomeric 69 neoline 191 neoline 14-O-acetyl- 192 neoline 8-0-acetyl- 15a-hydroxy- 192 Neolitsea hiiranensis sesquiterpenes 15 1 Neolitsea villosa benzylisoquinolines 389 Neomeris annulata sesquiterpenes 152 neomrensic acids synthesis 656 neopinguisane 158 neopinone biosynthesis 362 neosarracine 658 neosiphoniamolide A 270 Neosiphonia superstes metabolites 270 Neouvaria acuminatissima diterpenoids 24 neover1-ucosan-5~-01,279 Nepeta caesarea monoterpenoids 480 Nepeta cataria plant phenolics 84 Nepeta discolor monoterpenoids 480 nepetalactol 85 hydrogenation 5 11 nepetalactone 85 nepetalactone dihydro- synthesis 5 10 Nepeta racemosa iridoids 121 monoterpenoids 48 1 Nepeta troodi monoterpenoids 48 1 Nepeta tuberosa tuberosa monoterpenoids 48 1 Nephila clavata tryptamines 416 nephilatoxin-7 synthesis 416 Nephthea albida oleanane triterpenoids 67 1 Nephthea chabroli metabolites 28 1 sesquiteIpenes 15 1 155 nephthol-A 281 nephthol-B 281 neplanicin A biosynthesis 369 Nerium oleander triterpenoids 674 Nerocallitropsis puncheri sesquiterpenes 153 nerol 9 1,482,484 epoxidation 483 nerolidol 145 neryl acetate asymmetric dihydroxylation 483 1-28 Natural Products Reports 2997 neryl butyrate 483 neryl isovalerate 483 neuraminic acid N-glycolyl- v(3) Neurospora crassa fatty acid biosynthesis 346 Nicandra physalodes tropane alkaloids 649 nickel hyperaccumulation 86 Pieris rapae 83 Nicotiana alata induced chemical defence 89 Nicotiana gossei sugar esters 9 1 Nicotiana spp.fatty acids 165 Nicotiana sylvestris nicotine 88 Nicotiana tabacum aristolochene 125 brassinosteroids 7 diterpenoids 133 induced chemical defence 89 monoterpenoids 487,494 505 Nicotiana umbratica sesquiterpenoids iii(6) nicotine 88,92 Nierembergia hippomanica pyrrolidine alkaloids 638 nigranoic acid dimethyl ester 663 nigrum-24-en-3-one 662 nkkomycins biosynthesis 368 Nilaparvata lugens schaftoside 90 nilotin 668 niphatesine C 274,638 Niphates spp.metabolites 274 pyridine alkaloids 638 nishiandaside structure 507 nitidanin 67 nitidine 396 synthesis 396 nitidine 0x0- synthesis 396 nitramine 646 nitraramine 647 Nitraria hillardieri spiropiperidine alkaloids 647 Nitraria komarovii quinazoline alkaloids 17 Nitraria schoheri spiropiperidine alkaloids 647 Nitraria spp.spiropiperidine alkaloids 647 nitrile hydrolase Rhodococcus rhodochrous J1 v(l) nitriles conversion into acids Rhodococcus rhodochrous v(4) conversion into amides Rhodococcus rhodochrous v(4) hydroxy conversion into lactones v(2) nitro compounds aromatic 84 nitrogenous microbial metabolites biosynthesis 359-372 Nitzschiapungens domoic acid 458-459 nivalenol 3-acetyldeoxy- 127 Nocardia hrasiliensis brasilidine A iii(6) nocardicins 31 1 nodakenine 6”-acetyl- 467 nodusmicin 531 nogalamycin 100 nojirimycin 645 nona-3,8-dienoic acid hydrogenation 173 nonanoic acid 8-amino-2-methyl-7-0~0- iv( 1) nona- 1,3,7-triene 4,8-dimethyl- 131 nona-2,4,6-triene 5-ethyl-3-methyl- biosynthesis 350 non-3-enoic acid synthesis 173 non-8-enoic acid synthesis 173 non-8-enoic acid 9-(2-butyIcyclopentyl)-, methyl ester synthesis 169 nopinone conversion into verbenone 496 noracronycine 19,617 noracronycine 5-hydroxy- 615 617 12-noralliacolide synthesis 150 noranonaine N-formyl- 398 Subject index norarmepavine 389 norbinaltorphimine pharmacology 404 28-norbrasinolide structure 3 norbutsanguinine 304,306 Norcardia spp.fatty acid biosynthesis 340 13-nor-2,6( 10)-carotadiene 148 28-norcastasterone 1 structure 3 28-norcastasterone 6-deoxo- 2 structure 3 norcepharadioneB 399 norcepharadione B 7-chloro- 399 norcepharadioneB N-methoxy- 399 norchrysomelidial 124 norcoclaurine biosynthesis 361 362 methylation 363 norconessine 198 norcorydine 397 norcorytuberine, N-methoxycarbonyl4,O-dimethyl- synthesis 398 norcryptostyline N-camphorsulfonyl- 388 norcryptostyline-I 388 norcryptostyline-11 388 nordicentrine 397 nordidemnin N 290 nordomesticine N-trifluoroacetyl- synthesis 389 norephedrine configuration 387 norerythronolide B 6-deoxy- biosynthesis 534 nor-C-fluorocurarimine 12-hydroxy- 1 1 -methoxy-N-acetyl- 568 nor-C-fluorocurarine 12-hydroxy-11 -methoxy- 568 norfluorocurarine synthesis 569,570 norglaucine N-ethox ycarbonyl- pharmacology 399 norgraveoline 12 synthesis 605 norhemangerine N-formyl- 397 norhygrine 638 norisoacronycine dihydro- synthesis 616 norisocorydine 397 norjuziphine 389 norlignans 70 2-norlimacine 390 2’-norlimacine 390 norlobelol-I %ethyl- absolute configuration 642 norloline 658 normacusin B NMR 565 normacusine-B 565 nomantenine N-formyl- 397 nomantenine 7-formyldehydro- 397 nomuciferine 398 nomuciferine dehydro- 398 nornuciferine N-formyl- 398 nornuciferine N-formyldehydro- 398 noroxyhydrastinine 387 1-norplagiodial 124 2-norplagiolactone I24 norpleiomutine 580 9-norpluviine 304 306 10-norpluviine 304 306 10-norpluviine 1-0-acetyl- 304,306 10-norpluviine 1 ,lo-diacetyl- 304,306 norpseudoephedrine configuration 387 norpseudotropine tropane biosynthesis 360 norpurpureine 397 norsalutaridine N-methoxy carbonyl- synthesis 403 norsanguinine 304,306 norsesquibenihol 15 1 norsolorinic acid biosynthesis 546 norstephalgine pharmacology 399 northebaine dihydro- biosynthesis 362 northebaine N-formyl- 401 norvaline 5-hydroxy-4-oxo- biosynthesis 214 norwilsonirine N-trifluoroacetyl- synthesis 389 nosiheptide biosynthesis 370 Nostoc linckia polyketides 524 NO synthase inhibition p-aminobenzamidine vii(3) Nothapodytes foetida monoterpenoid indole alkaloids 584 nothapodytines 584 Nothopanaxdavidii oleanane saponins 672 nuciferine 79 nucleoside antibiotics biosynthesis 368-370 nudenoic acid iii(2) nudicaulidine 194 nudicauline 14-deacetyl- 193 pharmacology 196 nudicauline pharmacology 196 nummularine-K 77 nummularine-0 77 nummularine-P 77 nummularine-R 76,77 nummularine-S 76 nummularines 79 nummularine-T 77 nystatin AI 106 0 oasomycin B biosynthesis 536 obaberine 390 obionin A 460 oblongine 389 oblonginine 200 oblongolide synthesis 147 oblongulide structure 470 obovamine 578 obscurinervine NMR 574 obscurinervinidine NMR 574 oceanapamine 146,279 Oceanapia spp.fatty acids 172 metabolites 279 sesquiterpenoids 146 Ochroma lagopus neolignans 67 ocimene 91 Ocimum keniense monoterpenoids 48 1 Ocimum tenuzj7orum monoterpenoids 48 1 Ocotea atirrensis benzylisoquinolines 389 Ocotea bullata neolignans 67 Ocotea corymbosa sesquiterpenes 153 Ocotea foetus lignans 52 Ocotea gomezii aporphines 397 Ocotea meziana aporphines 397 Ocotea vellosiana aporphines 397 benzylisoquinolines 389 ocoteine 397 ocotominarisine 397 octacosanoic acid 2,4,6,8-tetramethyl- 340 octadecadienoic acid hydroperoxy - synthesis 174 octadeca-9,12-dienoic acid biosynthesis 346 octadeca-9,ll -dienoic acid 15,16-epoxy-13-hydroxy-, biosynthesis 348 octadeca-9,ll -dienoic acid 13-hydroperoxy- 178 octadeca-9,1 I-dienoic acid 13-hydroxy- biosynthesis 346 octadeca- 10,12-dienoic acid 10,13-epoxy-1 1 -methyl- 166 octadeca-9,12-dien-6-ynoic acid biosynthesis 346 octadeca-7,9-diynoic acid hydroxy- synthesis 168 oc tadecanoate thioes ter 3-oxo-2-tetradecanyl- biosynthesis 341 octadecanoic acid biosynthesis 343 346 octadecanoic acid 9,12-epoxy- 13-phenylselenenyl- synthesis 171 octadecanoic acid methyl- biosynthesis 340 octadecanoic acid 11,12-methylene- 164 octadecanoic acid monomethyl- biosynthesis 350 octadeca-6,9,12,15-tetraenoic acid biosynthesis 346 octadeca-6,9,12-trienoate,biosynthesis 344 octadeca-8,10,12-trienoicacid biosynthesis 346 octadeca-9,11 Strienoic acid 13-hydroperoxy- biosynthesis 348 octadeca-9,11,15-trienoicacid 13-hydroxy- biosynthesis 348 octadeca-9,12,15-trienoicacid biosynthesis 346 octadeca-9,12,15-trien-6-ynoic acid biosynthesis 346 octadecenoic acid biosynthesis 340 343 octadecenoic acid 9,10 I3-trihydroxy- 174 octadecenoic acid 9,12,13-trihydroxy- 174 octadec-6-enoic acid biosynthesis 347 octadec-9-enoic acid biosynthesis 347 octadec-9-enoic acid 12,13-epoxy- 179 octadec-9-enoic acid 11,12-epoxy-13-hydroxy-,179 octadec-9-enoic acid hydroxy- 179 octadec-9-enoic acid 13-hydroxy- 12-0xo- 178 octadec-10-enoic acid 12,13-epoxy-9-hydroxy- 179 octadec- 10-enoic acid 9-hydroxy- 12-0xo- 178 octadec- 1 1 -enoic acid 9,10-epoxy-l3-hydroxy- 179 octadec- 12-enoic acid 9,10-epoxy- methyl ester synthesis 168 octadec- 12-enoic acid 10,11-epoxy-9-hydroxy- 179 octadec-9-en- 1-01 hydrogenation 173 octadecenoyl ACP 336 fatty acid biosynthesis 347 octadec-7-yn- 1-01 10-methyl- synthesis 167 octalactin A 453 octalones synthesis 494 octanes 2,6-dimethyl- 478485 octanoate 7-methyl-3-oxo- biosynthesis 354 octanoic acid 8-hydroxy- deuterium-labelled synthesis 172 octanoyl ACP fatty acid biosynthesis 347 ~-manno-2-octulosonate 8-phosphate 3-deoxy- biosynthesis 438 oct-1-yn-3-01 synthesis 168 oct-2-yn- 1-01 deuterium-labelled synthesis 172 Odocoileus hemionus terpenoids 86 odolide 250 Odontosyllis undecimdonta metabolites 294 oduline 304 306 oduline 0-methyl- 304,306 okadaic acid 456,535 biosynthesis 545 esters 263 oleana-l1,13(18)-diene-~,16P,21~,23,28- pentol.671 oleana-l1,13( 18)-diene-q,16P,23,28,30-pentol 671 oleana- 12,2 1-dien-28-oic acid 3P,23-dihydroxy- 67 1 oleana- 1 1,13( 18)-dien-28-oic acid 3 P-hydroxy- 67 1 oleanane 13P,28-epoxy- 671 1-30 Natural Products Reports 1997 oleanane saponins 672 oleanane triterpenoids 669-674 oleanan-28,13P-olide 3P,23-dihydroxy-1la 12a-epoxy- 67 1 oleandolide 8,8a-deoxy- biosynthesis 534 oleandomycin 104,535 olean-12-en-28-al,3P,22P,24-trihydroxy- 67 1 olean- I2-ene 674 olean- 13( 18)-ene 674 olean- 18-ene 674 olean-12-ene-3P,l la 16P,21a,23,28-hexol 671 olean-1 1 -ene-3P 15a 16a,21 P,22a-pentol 13P,28Oepoxy- 67 1 olean- 12-ene-2&3P,22a-triol 67 1 olean- 12-en-28-oic acid 2a,3 P-dihydroxy- 671 olean-12-en-28-oic acid 3&27-dihydroxy- 671 olean- 12-en-28-oic acid 1 P-hydroxy-3-oxo- 669 olean- 12-en-28-oic acid 3P-hydroxy-ll-oxo- 67 1 olean- 12-en-28-oic acid 3P,6P,23-trihydroxy- 674 olean- 12-en-30-oic acid 3-OXO- 669 olean- 12-en-3P-01 16P,28-epoxy- 67 1 olean- 13( 18)-en-3-one 28-hydroxy- 669 oleanolic acid pharmacology 661 oleayunnanoside 508 oleic acid biosynthesis 346 347 hydrogenation 173 oleiferins 46 oleoside dimethyl ester 123 oleoside 7-glucosyl- 11-methyl- 123 oleoside 11-methyl- 123 oleosides biosynthesis 123 oleuropein 123 oligosaccharides biological role 99 oligotetrahydrofuran peptides vi(2) olivacene iv(3) olivanic acid 309 3 1 1 structure 311 olivetolic acid 592 olivil 52 olivomycin A 101 omphalane 148 Omphalanthusfiliformis sesquiterpenes 148 omphamurin 468 Onchidium spp.metabolites 288 onchitriol I structure 288 Oncorhynchus nerka fatty acids 164 oncorhyncolide 455 545 oospoglycol v(2) Ophiocoma echinata metabolites 294 Ophiocoma scolopendrina metabolites 294 Ophiocoma wendti metabolites 294 Ophiocomina nigra metabolites 294 Ophionereis reticulata metabolites 294 Ophionotus victoriae metabolites 294 Ophiotrix fragilix metabolites 294 Ophiozona impressa metabolites 294 Ophiura texturata metabolites 294 Ophrys insectifera pollination 9 1 oplodiol epoxy- structure 153 Oplopanax japonicus lupane triterpenoids 669 oplopanaxosides 669 oppositane 151-153 synthesis 153 oreasterosides 294 Oreaster reticulatus metabolites 294 Oreina elongata pyrrolizidine alkaloids 84 Oreina melanocephala pyrrolizidine alkaloids 83 Oreina spp.alkaloids 658 pyrrolizidine alkaloids 83 Oreocnide rubescens monoterpenoids 505 Origanum hypericifolium monoterpenoids 48 1 Origanum marjorana essential oils 478 Origanum rotundifolium monoterpenoids 48 1 Origanum solymicum monoterpenoids 48 1 Origanum syriacum monoterpenoids 48 1 Orina spp. metabolites 275 onpavine biosynthesis 362 Orixa japonica flavonoids 90 quinoline alkaloids 606,607 Ormosia alkaloids 32-37 628-633 analysis 628 chemical ecology 628-630 chemotaxonomy 628-630 detection 628,629 isolation 629 occurrence 628 spectroscopy 630-63 1 structures 630-631 synthesis 63 1 omithine clavulanic acid biosynthesis 320 Ornithopus sativus brassinosteroids 3,4 8 omoside 508 Ornthogalum sandersiae cholestane glycosides 108 oroselol synthesis 467 oroselone synthesis 467 orotidine monophosphate decarboxylase vi(4) orsellinic acid synthase 546 oryzaleneF 95 oryzalexin D 135 oryzalexin E 135 oryzalexin S 95 oryzalexins 134 Oryza sativa brassinosteroids 3,4 diterpenoids 138,248 gibberellin biosynthesis 226 HMG-CoA reductase 112 Oscillatoria agardhii glycopeptides iv(4) Oscillatoria nigroviridis metabolites 262 oscillatoxin D 262 oscillatoxin D 30-methyl- 262 Osmanthus asiaticus iridoids 508 Ostericum grosseserratum monoterpenoids 48 1 Ostertagia circumcincta quinoline alkaloids 13 ostopanic acid synthesis 168 ostreocin D 263 Ostreopsis siamensis metabolites 263 palytoxin 457 OSW-1 108 othonnine 658 Otobaparvifolia sesquiterpenes 145 ouabain synthesis 380 ouregidione 399 ovatuside 508 ovigerine 397 ovigerine N-formyl- 397 ovigerine N-formyldehydro- 397 ovigerine N-hydroxy- 397 oviposition deterrents 90-91 stimulants 90-91 15-0xaandrost-4-en-3-one, 4-hydroxy- synthesis 377 15-oxaandrost-4-en-3-one, 4-methyl- synthesis 377 4-oxa- 1 -azabicyclo[ 3.2.0]heptane 7-OXO- 316 oxadiazinone iii(3) 6-oxa-5a-pregnane-3,20-dione, synthesis 378 20-oxasqualene 2,3-oxido- 662 5-oxatridec-2-enoic acid 3,8,12-trimethyl- ethyl ester synthesis 168 oxazinones amino acid synthesis 208 oxaziridines camphorsulfonyl- NMR 498 oxaziridines perfluoro-2,3-dialkyl- oxidative cleavage of methyl ethers of steroidal secondary alcohols 375 oxazolidinones amino acid synthesis 208 oxidase amino acid synthesis 206 2P-oxidases 235 3P-oxidases 235 7-oxidases 235 20-oxidases 235 11,19-0xidopregn-4-ene-3,20-dione 21-hydroxy- synthesis 379 p-oximene epoxidation 483 oxindoles 559-565 3-oxoacyl ACP reductase fatty acid biosynthesis 338 3-oxoacyl ACP synthase fatty acid biosynthesis 337-338 338,347 3-oxoacyl ACP synthetase 335 3-oxoacyl synthases 335 3-0~0butanoyl ACP 335 3-oxobutanoyl ACP synthase fatty acid biosynthesis 338 3-oxo-A5-steroid isomerase structure vi(4) oxyacanthine 390 oxylipins biosynthesis 344 oxypeucedanin ethanolate 469 oxyte tracy cl ine sequence 528 Oxytropis caerulea swainsonine 23 Oxytropis imbricata swainsonine 23 Oxytropis kansuensis alkaloids 34 swainsonine 23 Oxytropis ochrocephala alkaloids 33 swainsonine 23 Oxytropis sericea swainsonine 24 Oxytropis spp.swainsonine 23 P P450 artificial steroid hydroxylation v(5) pachanol A 673 Pachliopta aristolochiae sesquiterpenes 150 paclitaxel 252 paclobutrazol 250 pactamycin 445 biosynthesis 441 padocin 62 Paederia scandens iridoids 508 monoterpenoids 507 paederinin 508 Paederus fuscipes pederin 85 Paederus riparus pederin 85 Paeonia japonica oleanane triterpenoids 67 1 Paeonia sufiruticosa monoterpenoids 486,494 oleanane triterpenoids 671 paeoniflorigenone synthesis 494 paeonilactone-B synthesis 494 paeonilactone-C synthesis 494 paeonisothujone 486 paeonisuffral 494 paeonisuffrone 494 paeonisuffrone deoxy- 494 paeonisuffrone synthesis 494 Paganum harmala quinazoline alkaloids 613 palauolol 424 palicoside 559 paliurine-B 77 Subject index Paliurus rarnosissimus cyclopeptide alkaloids 80 pallescensin A synthesis 147 epi-pallescensin A synthesis 147 pallidin 416 palmatine 392 pharmacological effects 393 palmatine,7-bromoethoxybenzyltetrahydro- pharmacological effects 393 palmatine,7-~hlorobenzyltetrahydro-, pharmacological effects 393 palmatine tetrahydro- pharmacological effects 393 palmitic acid C-isotope labelled synthesis 173 palmitic acid fluoro- synthesis 172 palmitoleoyl ACP 336 palmitoyl ACP 336 Palythoa caribaeorum metabolites 28 1 Palythoa tuberculosa metabolites 28 1 palytoxin 263,457 Panax ginseng triterpenoids 666 pancratistatin 303 304 Pancratium maritimum alkaloids 306 307 pandernine 75 pangenensines 579 Panicum miliaceum germination 92 Papaver bracteatum morphinan alkaloid biosynthesis 362 papaverine physiology 389 Papaver somniferum morphinan alkaloid biosynthesis 362 Papilio spp.oviposition deterrents 91 Papilio xuthus flavonoids 90 parabenzoinol 52 Parabenzoin trilobum lignans 52 paraherquamide B synthesis 418 Paralemnalia thyrsoides sesquiterpenes 158 paralinone iii(3) Paramignya monophylla coumarins 466 469 Paraquilegia anemonoides aporphines 397 Parasitellaparasitica HMG-CoA reductase 112 parathylone 158 Parazoanthus spp.metabolites 286 pareitropone 400 parietin 84 parinaric acid deuterium-labelled synthesis 173 parishin A 156 Parnassius phoebus sarmentosin 84 Parraquilegia anemonoides bisbenzylisoquinolines 390 panyin iv(4) parthenin 157 synthesis 157 parthenolide 15 1 parvifolin synthesis 148 paspaline 421 paspaline B 421 Pastinaca sativa furanocoumarins 88 patchoulane 149 155-157 patchouli alcohol synthesis 157 patellamide F 290 patensin 672 pathylacton A 158 Patrinia scabra iridoids 508 patriscabrol 508 paucidactine A 21-deoxy- 574 paucidactines 574 pauciflorines 574 Paulownia tomentosa iridoids 123 508 monoterpenoids 507 pavines 391 paxilline 421 paxilline 12-desoxy- 42 1 paxinorol 421 PC-766B.535 PDll6198 531 PDll6740 531,532 pectenotoxin 11 270 pederin 85 Pedicularis alaschania iridoids 508 Pedicularis plicata iridoids 508 Pedroxillano spp. lipoxygenases 178 peganidine deoxy- 17 peganine 17 peganine dehydroxy- hydrochloride dihydrate 17 peganine deoxy- 17 peganine N-oxide 17 peganine N-oxide deoxy- 17 peganol 17 peguangxienin 467 Pelargonium citronellurn monoterpenoids 48 1 Pelargonium graveolens dimethylallyl diphosphate 600 isopentenyl diphosphate isomerase 601 Pelargonium grossularioides monoterpenoids 48 1 Pelargonium roseum monoterpenoids 482 Pelargonium sidoides coumarins 47 1 Pelargonium spp.tryptamines 4 16 Pellia endiviifolia diterpenoids 254 peltatin 57 P-peltatin 44 penam ethylidene- 3 15 penaresidin A 270 Penares spp. metabolites 270 penduline 390 penem 315 penem 6-triazolylmethylene- 3 18 penicillanic acid 6-amino- acylation 3 10 biosynthesis 368 penicillanic acid N-(carboxymethyl)-6-amino-,3 18 penicillanic acid 6p-i0do- 3 17 penicillanic acid sulfone 3 17 penicillin G 310 penicillin N 3 14 penicillins 309 biosynthesis 321,367-368 Penicillium atrovenetum 3-nitropropanoic acid biosynthesis 2 14 Penicillium citreo-viride citreoazopyrone, iv(4) Penicillium citrinum monoterpenoids 494 Penicillium cyclopium isopentenyl diphosphate isomerase 595 polyketides 546 Penicillium digitatum monoterpenoids 488 Penicillium fellutanum fellutamides 46 1 Penicillium palitans quinoline alkaloids 1 1 Penicillium patulum fatty acid biosynthesis 346 6-methylsalicylic acid 523 polyketides 545 Penicilliumpaxilli indole alkaloids 421 Penicillium roquefortii aristolochene synthase 125 Penicillium simplissimum polyketides 548 Penicillium spp.lipases 178 metabolites 26 1 penitremone biosynthesis 364 penostatins 461 tryptamines 416 Penicillium viridicatum quinoline alkaloids 11 penitremones biosynthesis 364 penitrems biosynthesis 364 penochalasins 4 16 penostatins 461 penprosides 482 penstemide 507 Penstemon acuminatus iridoids 508 Penstemon barrettiae iridoids 508 Penstemon ovatus iridoids 508 Penstemon parryi iridoids 508 Penstemon procerus monoterpenoids 482 Penstemon serrulatus monoterpenoids 507 pentacosa-5,9-dienoic acid 6-bromo- biosynthesis 344 pentadecanoic acid 14-methyl- biosynthesis pentadecanoic acid 3-methyl- 1 5-phenyl- C-isotope labelled synthesis 173 penta-2,4-dienals synthesis 168 pentalenene biosynthesis 125 pentanoate 3-hydroxy- biosynthesis 343 pent-2-en- 1,5-dioic acid 340 pent-4-enoic acid 5-(2-octylcyclopentyl)- methyl ester synthesis 169 perakine 565 biosynthesis 365 perakine dimethyl acetal 565 peregridinine 194 peregrine 193 194 peregrine 14-O-acetyl- 193 194 peregrine 14-O-benzoyl- 193 peregrine 10-hydroxy- 193 peregrine 14-O-methyl- 193 peregrine alcohol 194 perfamine 14 perforatinolone 668 pericyclivine NMR 565 pericyclivine 10-methoxy-N,-methyl- 565 Peridroma sansia hirtin 89 Perilla frutescens limonene synthase I 17 monoterpenoids 486 sesquiterpenes 128 perillene 91 perillyl alcohol synthesis 495 periplanone B synthesis 15 1 Perknaster fuscus metabolites 274 permissine 198 Perna canaliculus metabolites 288 peroxidase selective oxidation v(6) Perrottetia multijlora monoterpenoids 505 perrottetinen 5 I1 Persea tolimanensis monoterpenoids 48 1 persianone 245 Peschiera afinis monoterpenoid indole alkaloids 578 Pesduxayniass nacahterlla pyrrole alkaloids 637 pessoine 392 petasine 155 synthesis 155 Petasitis hybridus sesquiterpenes 155 Petasitis japonicus sesquiterpenes 155 Petasitis spp.sesquiterpenes 155 petroselinic acid 178 biosynthesis 347 Petrosiaficiformis metabolites 270 Petrosia spp. fatty acids 171 172 petrosin 37-38 petrosin A 38 petrosin B 38 Petteria ramentacea alkaloids 34,35 Peucedanum guangxiense coumarins 466 peguangxienin 467 Peucedanum japonicum coumarins 466 khellactone 467 Peucedanum ostruthium coumarins 466 469 Peucedanumpraeruptorum coumarins 466 467 Peucedanum spp. coumarins 465 Peucedanum zenkeri monoterpenoids 48 1 Phacelocarpus labillardieri metabolites 267 Phacelocarpuspeperocarpos metabolites 267 1-32 Natural Products Reports 1997 Phaedon amoraciae iridoids 124 Phaedon cochleariae iridoids 124 Phaeocystis pouchetii chemical signaling 86 Phaeodactylum tricornutum fatty acid biosynthesis 344 fatty acids 166 metabolites 263 Phaeophyta secondary metabolites 458,459 Phaeosphaeria spp.gibberellin 139 gibberellin biosynthesis 234 Phaeospheria spp. gibberellins 25 1 Phagnaton sinaicum monoterpenoids 48 1 Phakellia costata metabolites 274 Phakellia falabellata pyrrole alkaloids 637 Phakellia spp. metabolites 270 phakellistatins 274 Phallus impudicus dimethyl disulfide 91 monoterpenoids 48 1 phamine 304,306 Phanerochaete chrysosporium lignans 45 Phaphisiapallida tryptamines 4 16 Pharbitis purpurea brassinosteroids 4 phaseic acid 132 phaseic acid dihydro- 4’-O-glucoside 132 Phaseolus aurex brassinosteroids 5 Phaseolus coccineus gibberellin biosynthesis 226 Phaseolus lunatus sesquiterpenes 132 Phaseolus vulgaris brassinosteroids 1,4 5,7 diterpenoids 138 gibberellin biosynthesis 226 Phebalium spp.sesquiterpenes 157 phellamurin 90 a-phellandrene 486,488 P-phellandrene 1 17 120 Phellinus tremulae tremulenediol iv(6) Phellodendron amurense flavonoids 90 Phellodendron protenor flavonoids 90 Phellodendron xuthus flavonoids 90 phenanthrene 2,4,7-trihydroxy- 9,lO-dihydro- 552 phenanthrenes 399 phenanthridine 8,9-methylenedioxy- 304 306 phenanthroindolizidine alkaloids 3 1 626-627 phenanthroindolizidines 6 19 phenanthroquinolizidine alkaloids 3 1 626-627 phenazine alkaloids biosynthesis 366 phenazine-1-carboxylic acid bios ynthesis 366 phenazine- 1 -carboxylic acid 6-aceto- 448 phenazine-1-carboxylic acid 2-hydroxy- biosynthesis 366 phenazine- 1,6-dicarboxylic acid 447 phenazines biosynthesis 446-449 phenethyl acetate 9 1 phenolics 87 phenol phthiocerol 340 phenols o-dihydroxy- 92 phenylalanine isotope-labelled synthesis 205-2 12 pheromones 85-86 synthesis and bioactivity iii(5) philoxeroic acid 67 1 phleic acids 340 Phleum pratense fatty acids 167 Phlomis younghusbandii iridoids 508 phlorethol 265 Phoca hispida fatty acids 164 phomactins 261,460 Phoma putaminum putaminoxin 92 Phoma spp.metabolites 261 phomactins 460 polyketides 547 Phomopsis foeniculi monoterpenoids 482 Phorbas spp.metabolites 270 phorboxazoles 270 phosphatases isopentenyl diphosphate isomerase activity assay 594 phosphoglycolipids 107-108 structure-activity relationship 107-108 phosphomevalonate kinase 1 13 phosphoranesulfinyl bromide menthoxyphenylthioxo- 489 photooxonerol 482 phthalide-isoquinolines,394 p h ycops i senone 27 8 Phycopsis spp. metabolites 278 phyllamyricins 56 Phyllanthus myrtifolius lignans 56 Phyllogorgia dilatata metabolites 28 1 sesquiterpenes 158 Phyllophora nervosa fatty acids 164 phylloquinones 592 Physalis peruviana tropane alkaloids 649 physoperuvine 649 physostigmine synthesis 420 phytanic acids deuterium-labelled synthesis 172 phytoalexin response 93-96 phytoalexins biosynthesis 591 p hy tocas sanes 248 phytodienoic acid 12-0xo- 174 biosynthesis 362 deuterium-labelled 172 synthesis 169 phytoene biosynthesis 222 59 1 Phytolacca acinosa oleanane saponins 672 Phytolacca bogotensis saponins 672 Phytolaccapolyandra oleanane saponins 672 Phytolacca rivinoides saponins 672 Phytophthora cactorum elicitins 93 Phytophthora infestans indole alkaloids 41 3 phytoplankton marine natural products 259-263 p hy to toxins 92-93 phytuberin 155 phytuberol 93 phytyl heptanoate 245 PI-080 108 Picea abies monoterpene hydrocarbons 477 Picea jezoensis triterpenoids 676 Picea sitchensis brassinosteroids 4 essential oils 478 pichierene 676 pichierenone 676 piclavine A 290 piclavines 633 picrasinol D 669 Picrasma ailanthoides quassinoids 669 Picrasma javanica quassinoids 669 picrinine 565 picrinine 10-methoxy- 565 Picris hieracioides oleanane triterpenoids 671 triterpenoids 674,676 picropodophyllin 4’-demethyldeoxy- 57 picropodophyllone 59 Pieris brassicae induced chemical defence 89 oviposition deterrents 90 Pieris rapae chlorogenic acid 90 induced chemical defence 89 nickel hyperaccumulation 83,86 tropaeolin 90 pig liver isopentenyl diphosphate isomerase 595 piliformoic acid iv(4) pilosanone C 247 pimaradiene 135 pimaranes 247-248,250 pimeloyl CoA fatty acid biosynthesis 354 pimpifolidine 198 pinanes 494-498 oxidation 495 synthesis 495 pinene synthesis 494 a-pinene 120,495 epoxidation 496 oxidation 495 reduction 495 P-pinene 120 oxidation 495 pinene synthases 117,494 pinguisane 158 pinguisone 13 1 pinidine 643 biosynthesis 360-361 synthesis 503 pinitol 90 pinnaic acid 633 Pinna muricata alkaloids 633 metabolites 288 pinnatasterone 24-0-(pyrrole-2-carboxylate) 89,200 pinnatoxin A 288 pinocamphones 120,495 pinocarbone reaction with cycloheptatriene 496 pinocarveol 120,494 pinocarveyl hydroperoxide 494 pinocarvone synthesis 495 pinol 4a-hydroxy- synthesis 492 pinolenic acid 164 pinolidoxin 92 pinoresinol 45 synthesis 54 Pinus abies monoterpenes 478 Pinus contorta 3-carene 117 diterpenoids 135 monoterpene cyclases 119 monoterpenoids 503 P-phellandrene 117 Pinusflexibilis monoterpenoids 477 Pinus heldreichii monoterpenoids 48 1 Pinuspeuce monoterpenoids 48 1 Pinus pinaster P-famesene 125 isopentenyl diphosphate transport 600 Pinus ponderosa pinidine biosynthesis 360 piperidine alkaloids 643 Pinus pumila monoterpenoids 481 Pinus radiata isopentenyl diphosphate isomerase 597 Pinus sylvestris brassinosteroids 4 fatty acids 165 Pinus tabulaeformis monoterpenes 478 monoterpenoids 48 1 Pinus thunbergii brassinosteroids 4 Piper aduncum monoterpenoids 486 Piper clarkii lignans 52 piperdarine 641 piperdial 130 Piper gaudichaudianum monoterpenoids, 48 1 piperidine 24 1D 643 piperidine 4-hydroxy- 1-methyl- esterification 360 piperidine alkaloids 637-65 1 biosynthesis 539-361 piperitenone 1 19 piperitol demethyl- 54 piperitol 6’-hydroxy- 54 piperitol hydroxyisopentenyl ether 54 piperitone 487,488 Piper nikanianum monoterpenoids 48 1 Piper schmidtii neolignans 66 Piper tuberculatum piperidine alkaloids 64 1 pyridone alkaloids 640 Piper wightii lignans 52 piplaroxide 640 Piptostygma fugax triterpenoids 663 piscicidol F 668 piscidinol B 666 pisiferic acid 250 Pistia stratiotes sesquiterpenoids 145 Pisum sativum brassinosteroids 2,4 diterpenoids 136 gibberellin biosynthesis 222,226 prenyltransferases 600 Pittosporum balfourii monoterpenoids 48 1 pituranthoside 465 Pituranthos triradiatus coumarins 465,466 pityol 85 Pityophthorus spp.pityol 85 Placopecten magellanicus metabolites 288 plagichilines structures 157 Plagiocarpus axilluris alkaloids 629,630 Plagiocarpus spp. alkaloids 630 Plagiochasma rupestre sesquiterpenes 15 1 Plagiochila cristata diterpenoids 254 Plagiochila ovalifolia sesquiterpenes 157 plagiochiline A structure 157 Plagiodera versicolora 8-hydroxygeraniol 84 iridoids 124 plagiodial 84 124 biosynthesis 507 Plakinastrella spp. metabolites 270 plakoric acid 270 plakoridine A 638 plakoridine B 270 Plakortis halichondroides fatty acids 164 Plakortis spp.metabolites 270 pyrrolidine alkaloids 638 plakortolide 270 plancheine 14,15-didehydro- 560 planococcyl acetate synthesis 477 P1 antae green 459 secondary metabolites 459 Plantago lanceolata oviposition stimulants 91 plant-animal interactions 8692 plant defensin 93 plan-microbe interactions 92-96 plant-parasite interactions 92 plant phenolics 84 plant-plant interactions 92 plants fatty acid biosynthesis 346-348 polyketides 55 1-553 Plasmodium vickei petteri quinoline alkaloids 607 plastoquinones 592 Platanthera spp. pollination 91 Platanus acerifolia phytoalexins 95 platydesmine 11,606 platydesmine 7,8-dimethoxy- 11 platydesmine 8-methoxy- 12 platydesmine N-methyl- 1 1,606 platynecine synthesis 654 platynecine 9-angelyl- 658 platyphyllide synthesis 153 platyphylline 658 platyphylloside 87 plecomacrolides 535 Plectrunthus coleoides monoterpenoids 48 1 Plectranthus heteroensis diterpenoids 249 sesquiterpenes 158 Plectronia odorata cyclopeptide alkaloids 80 pleicarpamine 16-hydroxymethyl- 560 pleiocarpamine 560 Pleurobranchaea meckelii diterpenoids 245 metabolites 287 pleuromutilin 255 Pleurotusflabellatus monoterpenoids 482 Pleurotus sajorcaju monoterpenoids 482 Pleurotus spp.fatty acids 165 Plexaura homomalla fatty acids 164 plicatoside-A 508 plicatoside-B 508 Pluchea arguta sesquiterpenes 15 1 plukenetione iii( 1) Plumeria ohtusa iridoids 508 pluviatolide 48 Pocillopora damicornis metabolites 28 1 podocarpic acid 250 Podocarpus nagi diterpenoids 249 Podocarpus totara waihoensene iii(5) podopetaline 34 podophyllotoxin 43,44,45,57 synthesis 57 podophyllotoxin,4-0-butanoyl-4’-demethyl- 44 podophyllotoxin deoxy- 59 podoph yllotoxin 2P-hydroxy-4’-demethyldeoxy- 57 Podophyllum spp.podophyllotoxin 43 Podura aquatica poduran iii(4) poduran iii(4) Poecilanthe spp. alkaloids 630 Poecillastra laminaris metabolites 28 1 Poecillastra spp. metabolites 270 Pogonatum urnigerum fatty acids 164 pollination interactions 9 1-92 polyacetylenes fatty acid biosynthesis 348 Polyalthia cheliensis diterpenoids 246 Polyalthia longifolia diterpenoids 246 polyalthic acid 246 polyandrasides 67 2 polyandrol 669 polycanthisine 30-3 1 Polycarpa aurata bisindole alkaloids 423 Polycavernosa tsudai metabolites 266 polycavernosides 266 polycistrins 637 Polycitor spp.metabolites 290 pyrrole alkaloids 637 polycitrin A 290 polyenes 106107,539 mode of action 106-107 Polyfibrospongia spp. metabolites 270 polygalagenin 67 1 Polygala japonica oleanane saponins 672 oleanane triterpenoids 67 1 Polygala reinii oleanane saponins 672 polygalasaponins 67 1 672 Polygala senega oleanane saponins 672 polygodial synthesis 147 polygodial 3a-acetoxy- 146 polygodial 3P-acetoxy- 146 polygodial 12a-acetal 3P-acetoxy- 146 polygodial 12P-acetal,3P-acetoxy- 146 polygodial 12-dimethylacetal 3a-acetoxy- 146 polygonapholine iii(3) Polygonatum alte-lobatum pol ygonapholine iii(3) polyhydroxyalkanoates biosynthesis 339 pol yketides aromatic 526533 biosynthesis 523-556 non- aromatic 53 3-544 Subject index 1-33 Polymnia sonchifolia acetophenone phytoalexins 95 polyneuridine NMR 565 polyodonine 245 polyoxins biosynthesis 368 polysaccharides 459 Polytolypa hystricis triterpenoids 675 polytolypin 675 Polytrichum formosum coumarins 466 471,472 polyunsaturation fatty acid biosynthesis 336 Pometia eximia saponins 672 Populus tremuloides isoprene synthase 113 porantheridine 6 19 Poraqueiba guianensis sesquiterpenes 152 Poria COCOS triterpenoids 662 poricoic acids 662 Poronia piliformis piliformic acid iv(4) Porophyllum ruderale monoterpenoids 48 1 porosadienone synthesis 158 porosin synthesis 67 Porphyra spp.fatty acids 165 Porphyra umbilicalisau fatty acid biosynthesis 345 Porphyridium cruentum secondary metabolites 459 Portulaca pilosa diterpenoids 247 portulal 247 potanidine A 194 potanidine B 194 potanine 194 potassium permanganate:copper sulfate steroid alkene epoxidation 374 Poteriochromonas malhamensis enol sulfates 458 pradimycins biosynthesis 533 Prasinococcus capsulatus pol ysaccharides 459 Prasinophyta secondary metabolites 459 Prasinophytes secondary metabolites 459 prebiotic chemistry vi(6) precapnelladiene synthesis 150 precapnellane 15&15 1 predicentrine 397 prednisolone crystal structure 373 pregnacalciferol 20-0x0- synthesis 379 1,4-pregnadien-3-0ne 16a 17a-orthoacetate ethyl 2 1 -acetoxy- 1 1 P-hydroxy- crystal structure 373 pregnanes partial synthesis 378-379 X-ray studies 373 pregnan-20-one 2-amino-3-hydroxy- NMR 373 5P-pregnan-20-one 3a-hydroxy- des-A analogues synthesis 379 5a-pregnan-20-one 2a,3P,6P-trihydroxy- 8 5a-pregnan-20-one 3a,15P 17a-trihydroxy- synthesis 379 pregnenolone NMR 373 14P 1 7a-pregn55-en-20-one 3P-acetoxy- synthesis 379 pregn-4-en-3-one 4-amino-20-hydroxymethyl- synthesis 378 prehalenaquinone biosynthesis 545 prekinamycin 532 prelaureatin biosynthesis 267 premcoryoside 508 Premna corymbosa iridoids 508 prenyltransferases 114-1 15 594 preocoteine 397 prephenic acid biosynthesis 433 prepinnarterpene synthesis 153 preraikovenal 158,457 pre-sambucoin 127 presqualene diphosphate conversion into squalene iv(2) preuplotin 457 Preussia aurantiaca auranticins 460 1-34 Natural Products Reports 2997 Prianos spp.bisindole alkaloids 424 metabolites 274 Primula spp. fatty acids 164 prionanthoside 470 determination 465 prion disease vi(5) pristanic acid deuterium-labelled synthesis 172 Pristimera grahamii triterpenoids 674 pristinamycinIIA biosynthesis 370 pristinamycins biosynthesis 370-37 1 proaporphines 396-397 probotrydiane 150 Procambarus clarkii fatty acids 166 proclavaminic acid biosynthesis 32 1 367 clavam biosynthesis 329 proclavaminic acid amidino hydrolase 327 330 [~-Pro~]didemnin B 290 prodrugs 101 progesterone 6a-fluoro- synthesis 37 8 proline hydroxy- isotope-labelled synthesis 216 proline isotope-labelled synthesis 2 15-21 7 proline-4-hydroxylase 324 prolyl-4-hydroxylase 324 pronuciferine 397 propanoic acid aryloxyphenoxy- biosynthesis 345 propanoic acid 3-hydroxy-3-phenyl- synthesis 504 propanoic acid hitro- biosynthesis 214 prop-2-enal,3-(5-hydroxy-3-0~0-2-pentyl-cyclopenty1)- 173 propionate P-hydroxy- clavulanic acid biosynthesis 321,327 Propionibacteria spp.fatty acid biosynthesis 343 Prorocentrum lima metabolites 263 polyketides 544 Prorocentrum maculosum metabolites 263 Prorocentrum spp.okadaic acid 456 prostacyclins biosynthesis 35 1 353 prostaglandin H2,9,11-epidioxy- biosynthesis 353 prostaglandins biosynthesis 344 351 353 synthesis 494 Prostheceraeus villatus metabolites 290 quinoline alkaloids 607 610 proteases molecular recognition vi(6) protein nucleic acids vi(5) proteins folding vi(5) amino acid monitoring v( 1) Proteus spp. P-lactamases 310 protists fatty acid biosynthesis 343-345 polyketides 544-545 Protium tenuifolium lignans 48 protoberberine alkaloids biosynthesis 363 protocatechuic acid biosynthesis 442 protoemetinol 0-demethyl- 395 protoemetinol desmethyl- 422 protoilludane 150-15 1 protopine dihydro- 393 synthesis 394 protopine 8-0xo- 393 protopines 393-394 405 protoveratrines 84 protozoa fatty acid biosynthesis 343-344 marine secondary metabolites 453464 provitamin D 1a-hydroxy- isomerization 383 provulosides 675 Prunella vulgaris triterpenoids 675 Prunus prostrata monoterpenoids 505 Pryeria sinica sannentosin 84 prymnesin 2 459 Prymnesiophyta secondary metabolites 459 Prymnesiophytes secondary metabolites 459 Prymnesiumparvum prymnesin 2 459 Psammaplysilla purea metabolites 270 277 Psammocinia spp.metabolites 280 Psammoclema spp. metabolites 279 pseudans 609 pseudans 3-methyl- 609 Pseudaxinyssa spp. fatty acids 164 pseudilin pentabromo- 455 Pseudoaxinella spp.metabolites 274 pseudocalanolides structures 469 Pseudoceratina crassa metabolites 276 Pseudocheirusperegrinus terpenoids 86 pseudocordatolide 470 Pseudodistoma kanoko metabolites 289 piperidine alkaloids 642 Pseudodistoma spp. metabolites 289 pseudodistomin C 289 pseudodistomins 642 pseudoephedrine estimation 387 pseudoephedrine N-methyl- configuration 387 pseudoguaiane 155-1 57 Pseudolabrus japonicus quinazoline alkaloids 6 12 tryptamines 41 8 Pseudolarix kaempferi diterpenoids 254 pseudolycorine 304,306 Pseudomonas aeruginosa fatty acid biosynthesis 339 p-lactamases 310 Pseudomonas aureofaciens phenazine alkaloid biosynthesis 366 Pseudomonas cepacia fatty acids 164 lipases 178 quinoline alkaloids 607 Pseudomonas cichorii acetophenone phytoalexins 95 Pseudomonas cichorr indolic phytoalexin biosynthesis 365 Pseudomonas citronellolis fatty acid biosynthesis 339 Pseudomonas cocevenenans fatty acids 167 Pseudomonas maltophilia monoterpenoids 505 Pseudomonas mevalonii HMG-CoA reductase 1 12 Pseudomonas spp.fatty acid biosynthesis 336 phenazine biosynthesis 446 anthranilate synthase 448 thiotropocin 438 pseudopalmatine 392 Pseudopterogorgia acerosa metabolites 283 Pseudopterogorgia americana metabolites 281,286 sesquiterpenes 147 Pseudopterogorgia hummelinkii metabolites 286 Pseudopterogorgia kallos metabolites 283 Pseudopterogorgia rigida metabolites 28 1 Pseudopterogorgia spp.metabolites 286 pseudotropine esterification 360 Pseudotsuga menziesii 3-carene 117 pseudovincadifformine synthesis 578 Pseumonas spp. phenazines 447 Psidium guyanensis monoterpenoids 48 1 Psidium incanum monoterpenoids 48 1 Psidium luridum monoterpenoids 481 Psidiumpohlianum monoterpenoids 48 1 Psoralea coryfolia coumarins 466 psoralidin 465 Psoralea corylifolia bakuchicin 467 coumestans 472 psoralidin 465,472 psudolaric acid B 254 Psychodaphalaenoides p-cresol 91 Psyllium spp. monoterpenoids 507 ptaquiloside 150 ptaquilosin 150 pterin enzymes v(5) Pterocaulon alopecuroides coumarins 466 47 1 Pterocaulon halansae coumarins 47 1 Pterocaulonpurpurascens coumarins 466 47 1 Pterocaulon virgatum coumarins 466,47 1 pteraenone 288 pteropodine crystal structure 563 isomerization 563 ptilocaulin 8P-hydroxy- 274 Ptilocaulis spiculifer metabolites 274 ptilomycalin A 274 294 Ptilota filicina fatty acid biosynthesis 344 fatty acids 165 Ptychanthus striatus diterpenoids 245 ptychantins 245 Ptychodera spp.metabolites 294 puberulins 67 pubescine-A 77,79 pubescinine 198 202 Pueraria lohata oleanane saponins 672 pulegone 119,486,487 biosynthesis iv(5) reactions 492,507 reduction 493 Pulsatilla patens oleanane saponins 672 pulvomycin biosynthesis 449 pumiliotoxin 25 1D 30 pumiliotoxin 25 1H deoxy- 29 pumiliotoxin C 15,611 pumiliotoxins 29-30,623 pummeline 6 I5 pumpkin isopentenyl diphosphate isomerase 597 punicalagin 88 punicic acid 164 punjabine 0-methyl- 390 purealidins 276 purpurasolol 47 1 pusilatins structures iii( 1) putaminoxin 92 putidaredoxin complexation with cytochrome P450cam vi(6) putranjivadione 673 putrescine cinnamoyl- biosynthesis 360 putrescine homospermidine biosynthesis v(6) puupehenol 12-chloro- 279 puupehenol 21-chloro- 147 puupehenol 15-0xo- 147,279 Pyacantha coccinea lignans 52 Pycnanthemumfloridanum monoterpenoids 48 1 pycnanthine 657 Pycnogonum litorale ecdy steroids 89 pygmaeocane 249 pyocyanin 446 pyranocoumarins 469 pyrazolecarboxylic acids iv(6) pyrazole fatty esters synthesis 170 pyrethrins 86 pyrethroic acid synthesis 485 pyrethroidinin 156 pyrethroids 121 Pyricularia oryzae phytoalexins 95 pyridine alkaloids 63745 1 pyridine monoterpene alkaloids 639 Subject index pyrido[4,3,2-mn]acridinealkaloids 462 pyridoacridine alkaloids 290 pyridone alkaloids 640-641 pyrido[ 1,2u]quinolin-6-one 1,2,3,4,6,11-hexahydro-,605 pyrimidine 2-amino-4-carboxy- iv( 1) pyrocincholic acid 67 1 Pyrococcusfuriosus citrate synthase v(6) Pyrola grandflora pollination 9 1 a-pyrone 6-pentyl- biosynthesis 346 a-pyronene 506 pyrostatins 260 pyrrolam A synthesis 653 pyrrole alkaloids 637-651 pyrrolidine alkaloids 637-65 1 biosynthesis 539-36 1 pyrrolidin-2-one 1 -benzyl-5 -buty 1- 625 8a-pyrrolizidine 7P-angelyl- 1 -methylene- 658 8a-pyrrolizidine 7a-angel yl-1-methylene- 65 8 8a-pyrrolizidine 7P-hydroxy -1 -methylene- 658 8a-pyrrolizidine N-oxide a-angelyl-1-methylene- 658 8a-pyrrolizidine N-oxide 7P-hydroxy- 1-methylene- 658 pyrrolizidine alkaloids 87,653-660 animals 83 Asteraceae 658 biological studies 659 biosynthesis 36 1-363 pharmacology 65 9 pyrrolizidin-3-one 2-methyl- synthesis 654 pyrroloazepine 637 pyrroloiminoquinone alkaloids 462 pyrr010[2,1-b]oxazole iii(6) pyrr010[2,l-b]quinazoline alkaloids,NMR 16 Pyrus spp.arbutin 93 pyruvic acid phenyl- biosynthesis 433 glucoside v(2) Pythium aphaidermatum fatty acid biosynthesis 348 Pythium debaryanum cyclopeptide alkaloids 79 Pythium ultimum lipases 178 Quararibeafunebris pyrrole alkaloids 637 Quassia multiflora squalene triterpenoids 661 triterpenoids 666 quassinoids 41 8,669 quassiols 66 1 quercetin glycosides 90 quercetin triglycoside 90 quercus lactone synthesis 483 Quercus petraea fatty acids 165 quianhucoumarins 467 Na-quinaldyl D-arginine hydrochloride 607 Na-quinaldyl L-arginine 610 quinazoline alkaloids 11-20 16-18 605-618,611-614 isolation 16-17,611413 structure 17-18 synthesis 17-18 quinazolin-4(3H)-one 2-acetyl- 16 quinic acid caffeoyl- 84 quinic acid l-caffeoyl-4-deoxy- 87 quinidine lanthanoid salts 581 reductive cleavage 58 1 quinidine 10-bromo- 10,ll -dihydro- synthesis 58 1 quinidine 3’,4’-dihydro- 581 quinidine 1 ’,2’,3’,4’-tetrahydro- 5 81 quinine lanthanoid salts 581 metabolites 581 quinine 0-demethyl- 581 quinine 3-hydroxy- 581 quinine 2’-0xo- 581 quinine glucumnide 58 1 quinine N-oxide 581 quinol tetraprenyl- 245 quinolidomicin 536 quinolinecis-195A decahydro- 6 11 quinoline 4-hydroxymethyl- 607,609 quinoline 4-methoxy-2-phenyl- 607 quinoline 2-( 3,4-methylenedioxyphenyl-ethyl)- 607 quinoline 2-pentyl- 607 quinoline prenyl- 12-1 3 quinoline 2-propyl- 607 quinoline alkaloids 11-20,605-618 animals 610-611 biogenetically related 581-588 decahydro- 15-16 microbial 609-610 monoterpenoid 13-14 non-terpenoid 11-12,605-607 occurrence 11 sesquiterpenoid 13-14 terpenoid rutaceous 607408 quinoline-4-carbaldehyde,607,609 quinoline-4-carbaldoxime 607,609 quinoline-4-carboxylic acid 607,609 quinolinium iodide 1,4-dimethyl- 607 quinolin-2-one 4-methoxy- 606 quinolin-2-one 4-methoxy- 1-methyl- 606 quinolin-2-one 3-prenyl-4-prenyloxy- 606 608 quinolin-2-one 3,4,8-trimethoxy- 1 1 quinolin-4-one 2-alkyl- 1 1 alkaloids 605 quinolin-4-one 2-aryl- 11 alkaloids 605 synthesis from 2-nitrochalcones 605 quinolin-4-one 2,3-dicarbomethoxy- 1 -methyl- 606 quinolin-4-one 1,2-dimethyl- 606 quinolin-4-one 2-(hept-2-enyl)-3-methyl- 607,609 quinolin-4-one 2-heptyl-8-methoxy-1 -methyl- 1 1 quinolin-4-one 2-heptyl-3-methyl- 607 quinolin-4-one 2-hexyl-8-methoxy- 1 1 quinolin-4-one 8-methoxy-2-( 3-methoxy- 4,5-methylenedioxyphenyl)- 1 -methyl- 606 quinolin-4-one 2-( 3-methoxy-4,5-methylene-dioxypheny1)- 1-methyl- 606 quinolin-4-one 8-methoxy- l-methyl-2-pentyl- 1 1 quinolin-4-one 3-methyl-2-(non-2-enyl)- 607 quinolin-4-one 3-methyl-2-nonyl- 607 quinolin-4-one I-methyl-2-pentadecyl- 1 1 quinolin-4-one 3-methyl-4-pentyl- 607 quinolin-4-one 1-methyl-2-tridecyl-8-methoxy-, 11 quinolin-4-one 2-(nona-3,6-dienyl)- 605 quinolin-4-one 2-phenyl- 12 quinolinone alkaloids dimeric 14 non-terpenoid 1 1-12,605-607 quinolizidine alkaloids 2141,619-636 quinolizidine lactone biphenyl- 32 quinolizidinol phenyl- 32 quinolizidinyl p-coumarate phenyl- 32 quinones diterpenoid 249 quinuclidine alcohol 581 qunghaosu synthesis 496 qunjkiaoside-A 508 Rabdosia angustifolia diterpenoids iii(4) Rabdosia longituba diterpenoids 25 1 racemocine 658 racemodine 658 racemonine 658 racemozine 658 radarin A synthesis 421 Radulaperrottetii cannabinoids 5 1 1 raikovenal 158,457 ramiflorines 579 Ranunculaceae alkaloids 658 rapamycin biosynthesis 435,436437,536 Raphanus communis gibberellin biosynthesis 222 Raphanus sativus brassinosteroids 3,4 diterpenoids 138 gibberellin biosynthesis 25 1 HMG-CoA synthases 11 1 Raphidophyta secondary metabolites 459 Raphidophytes secondary metabolites 459 rarisetenolide 458 iii(2) rarisetenolide,1lt12-epoxy- 458 Raspailia spp.metabolites 270 raspailols 270 rastevione mesylate 150 Rathbunia alamosensis oleanane triterpenoids 67 1 Ratibida mexicana sesquiterpenes 15 1 raucaffricine biosynthesis 365 raucaffrinoline 565 raumacline biosynthesis 365 raumacline 2 1-hydroxy- biosynthesis 365 Rauwolfia grandiflora iridoids 508 Rauwolfia sellowii monoterpenoid indole alkaloids 565 568 Rauwolfia serpentina monoterpenoid indole alkaloids 559 oxidising enzymes 12 1 vomilenine biosynthesis 365 Rauwolfia sprucei monoterpenoid indole alkaloids 560,565,568 rebaudioside A 136 Reboulia hemisphaerica sesquiterpenes 149,158 Rebutia marsoneri sesquiterpenes 132 red algae metabolites 266-267 red oak gallotannin 88 reduction keto esters Saccharomyces cereviciae vi(2) reglin 249,671 reiniosides 672 remrefidine 397 reserpine reduction 563 synthesis 565 resorcinol 5-(8’-heptadecenyl)- 95 resveratrol 93 95 Retama spp.alkaloids 630 retamine 34,630 structure 63 1 retamine dehydro- 630 retamine I ~-oxo-,630 reticulatosides 294 reticuline 389 biosynthesis 361 conversion into salutaridine 362 Reticulitermes operatus termite antifeedant activity 90 Reticulitermes speratus diterpenoids 246 11 -cis-retinal 140 retinal synthesis 506 retinoic acid 140 synthesis 506 retinoids 139 140 retinol 139 202 retinol dehydro- 140 retonecine 657 retrodendrin 57 retroisosenine 657 658 retroisosenine oxy- 657 retronecine 658 retronecine 7-angelyl- 658 retronecine 9-angelyl- 658 retronecine 7-angelyl-9-acetyl- 657,658 retronecine 7-angelyl-9-senecioyl- 658 retrorsine 658,659 determination 658 retrorsine dihydro- 658 retuline N-deacetyl- 568 Retzia capensis iridoids 508 R hadinoceraea nodicornis steroidal alkaloids 84 Rhaphanus sativus HMG-CoA reductase 112 Rhaponticum uniforum sesquiterpenes 152 rhazinilam 573 Rhazya stricta monoterpenoid indole alkaloids 559,573 monoterpinoid indole alkaloids 570 Rheum rhabarbium lupane triterpenoids 669 Rhinanthus angustifolius iridoids 508 Rhizoctonia leguminicola indolizidine alkaloids 22 Rhizoctonia solani betavulgarin 95 5,7-dihydroxychromone 93 monoterpenoids 487 Rhizopus delemar lipases 178 Rhizopus nigricans sesquiterpenes 153 Rhizopus stolonifer diterpenoids 25 1 Rhodobacter spheroides spheroidenone v( 3) Rhodococcus rhodochrous J1 nitrile hydrolase v( 1) Rhodococcus ruber fatty acid biosynthesis 343 Rhodophyta secondary metabolites 459 Rhodospirillium rubrum diterpenoids 249 Rhodotorula rubra quinoline alkaloids 14 rhoifolinic acid methyl ester 606 Rhoipte lea chiliantha lupane triterpenoids 669 oleanane triterpenoids 67 1 triterpenoids 674 rhoiptelic acid 674 rhombifoline 34 35,629,630 NMR 35 rhombifoline tetrahydro- 34 35 Rhus coriaria monoterpenoids 48 1 Rhytidoponera chalbaea polyketides 553 ribalinine 11 606 Ribes nigrum fatty acids 164 ribonucleotide reductase active metal centre v(1) Riccardia crassa sesquiterpenoids 145 riccardiphenol 145 Ricinus communis diterpenoids 133 135 fatty acid biosynthesis 347 isopentenyl diphosphate isomerase 597 riddelline 658 Riesling acetal synthesis 506 rietone 145,281 rietone 8’-acetoxy- 145,281 rietone 8’-deoxy- 145 28 1 rifam ycin biosynthesis 440,44 1 molecular genetics 443-444 biosynthetic gene 442 rifamycin B biosynthesis 440 rigidin 637 rinderine 83 rinderine 3’-acetyl- 657 rishitin 93 96 155 rishitin 11,12-epoxy- 96 rishitin 13-hydroxy- 96 ritterazineK synthesis 382 ritterazines 198-1 99,290 pharmacology 201 Ritterella tokioka alkaloids 196 198-1 99 pharmacology 201 metabolites 294 RM18 526,528 RM18b 526 RM20 528 RM20b 528 RM20c 528 RNA prebiotic synthesis vi(6) Robinia pseudoacacia brassinosteroids 4 monoterpenoids 48 1 robustadial-A synthesis 496 robus tadial-B synthesis 496 robustamine 397 robustine 606 robustine N-hydroxy- 199-200,200 Roemeria hybrida proaporphines 397 roemerine 397 pharmacology 399 roemerine dehydro- pharmacology 399 Romalea guttata plant phenolics 84 Rosa centifolia monoterpenoids 48 1 Rosa taiwanensis triterpenoids 674 rosefuran synthesis 477 rosmarinine 658 v(3) rosmarinine-2-acetate 658 rotundifolic acid 666 roxiamines 606,608 rubellosides 675 rubernoic acid C 455 rubicunoside A 672 rubijervine 12P-hydroxy- 200 rubivirine 200 rubralins 668 Rubus pinfaensis triterpenoids 674 rugosanine-A 77 rugosanine-B 76 rugosanines 79 rugosinone 391 rugosinone dihydro- 391 rumphioside A 247 Ruspollia hypercrateriformis pyrrolidine alkaloids 638 Russula emetica sesquiterpenes 150 Russulaflavida triterpenoids 676 russulaflavidin 676 Rutaceae alkaloids 605 rutaecarpine 416,611 rutaecarpine 1-hydroxy- 416,611 pharmacology 4 16 rutaecarpine 7-hydroxy- 17 rutaecarpine 1-methoxy- 416,611 Ruta graveolens coumarins 466,470 N-methyltransferase 366 quinoline alkaloids 14 rutaretin synthesis 470 ruthenium tetroxide steroid alkene epoxidation 374 S sabialactone 67 1 sabianone 669 sabinene 89,9 1 120 photochemistry 505 reactions 505 Sabinia swinhoei oleanane triterpenoids 67 1 Saccharomyces cerevisiae keto ester reduction vi(2) polyketides 545 Saccharopolyspora erythraea fatty acid biosynthesis 337,339 342 352 1-36 Natural Products Reports 2997 polyketides 533 Saccharopolyspora hirsuta polyketides 53 1 Saccharum spp.fatty acid biosynthesis 348 sacculatane 254 sachaconitine 192 sachaconitine 14-O-acetyl- 192 sacridicene 66 1 saikaogeninQ 67 1 saikosapons 672 sakuranetin 93,95 Salacia beddomei lupane triterpenoids 669 salacianol 669 salacianone 669 salannal 669 salicifoline 48 salicin 84 salicortin 2’-O-acetyl- 90 salicylic acid 96 salicylic acid 6-methyl- 523 biosynthesis 545 fatty acid synthetases 345 salinamides 453 Salixpentandra phenolic glycosides 90 Salix sachalinensis lignans 52 neolignans 67 oligomeric lignans and neolignans 69 salprionin 249 salsolidine synthesis 388 salsolinol synthesis 388 saltivanine-K 76 salutaridine biosynthesis 361 synthesis from reticuline 362 salutaridinol biosynthesis 362 Salvia candicans diterpenoids 249 Salvia candidissima diterpenoids 249 Salvia cryptantha monoterpenoids 48 1 Salvia dorisiana monoterpenoids 48 1 Salvia heldrichiana diterpenoids 249 Salvia lanigera diterpenoids 249 Salvia miltiorrhiza danshenols iv(4) sesquiterpenes 15 1 Salvia napifolia diterpenoids 249 Salvia officinalis camphor 121 1,8-cineole synthase 117 monoterpene cyclases 120 monoterpenoids 477,494,498 pinene synthase 117 Salviaparryi parryin iv(4) Salvia pomifera monoterpenoids 48 1 Salvia prionitis diterpenoids 249 Salvia regla oleanane triterpenoids 671 Salvia sclarea monoterpenoids 48 1 salviasperanol 249 sambucoin 127 sandaracopimaradiene 134 135 sandaracopimaric acid 247 reactions 377 sandensolide 28 1 Sandoricum koetjape saponins 672 sandramycin 6 10 sanggenons structure iii(5) sanguinarine 395 physiological effects 396 sanguinarine 6-acetonyldihydro- 396 sanguinarine dihydro- 396 sanguinarine 6-methoxydihydro- 396 sanguinarine 6-0xo- 396 sanguinine 304,305,306 Sanguisorba minor 2,6-dihydroxymethoxy-acetophenone 94 sanjoinine-Ah1 79 sanjoinine-B 77 sanjoinine-D 78 sanjoinine-F 77 sanjoinine-G1 78 sanjoinine-G 1,O-methyl- sanjoinine-G2 79 sanjoinine-G2 77 P-santalene 148 epi-p-santalene 148 Santalum album sesquiterpenes 148 santolinyl 485486 sapelinD 661 saphenamycins 446 biosynthesis 44748 saphenic acid 446,448 Sapium japonicum fatty acids 167 saponins 672 sapriparaquinone ~-oxo- 249 Sarcococca vagans a- 199 sarcomegistine 11 14 Sarcomelicope dogniensis acridone alkaloids 6 15 quinoline alkaloids 605 606 Sarcomelicope megistophylla quinoline alkaloids 11 14 sarcophylline 390 Sarcophyton solidum diterpenoids 253 metabolites 283 Sarcophyton spp.metabolites 282 sarcotol 252 sarcotal acetate 282 sarcotol 252 282 sarcotol acetate 282 sargassumketone 264 Sargassum kjellmanianum metabolites 264 Sargassum spinuligerum metabolites 266 sarmentosin 84 sarpagan synthesis 565 sarpagine 565-568 &,-methosalt 565 sarracine 658 sarsolenone 253,283 sativanine-H 77 Satureja boliviana monoterpenoids 481 Satureja cilicia monoterpenoids 481 Satureja gilliesii monoterpenoids 486 Satureja odora monoterpenoids 48 1 Satureja pamiflora monoterpenoids 48 1 Satureja wiedemanniana monoterpenoids 48 1 saturejol acetyl- 486 saturejol isoacetyl- 486 Sauromatum guttatum dimethyl disulfide 9 1 savinin 49 saxitoxin 457 scalarin 25-dehydroxy- 12-epi-deacetyl- 28 1 scandenin 4,4’-di-O-methyl- 472 Scapania undulata scapaundulin B iii(3) scapaundulinB iii(3) Sch52900 427 Sch 52901 427 schaftoside 90 schelhammericine 404 schelhammericine,3-epi-12-hydroxy- 404 schelhammeridine dihydro- 405 schinicoumarin 472 schinilenol 470 schinindiol 470 schisantherins 60 Schismocarpus matudai iridoids 508 schismoside 121 schismoside 121 508 Schistosoma mansoni quinoline alkaloids 13 Schistostepium heptalobum monoterpenoids 48 1 Schizachrium scoparium diterpenes 92 Schizandra chinensis lignans 45,61 schizandrin 44 48 schizandrin deoxy- 47 synthesis 61 Schizanthus integrifolius pyrrolidine alkaloids 638 schizotenuin D 67 Schizothrix calcicola metabolites 262 schmiditin 66 scillarenin conversion into bufotoxin 380 sclaradial structure 28 1 sclareol 134 Sclerodoris tanya metabolites 288 sesquiterpenoids 146 Sclerotiurn rolfsii 5,7-dihydroxychromone 93 scoparone 465,470 scopolamine analgesic effects 403 biosynthesis 359 scopoletin 95 470 determination 465 scopolin 470 scoulerine biosynthesis 363 scoulerine 1 2-chloro- pharmacological effects 393 scrophaenoside- 1 508 scropheanoside-2 508 scropheanoside-3 508 Scrophularia korainensis iridoids 508 Scrophularia scorodonia iridoids 509 Scrophularia spicata iridoids 509 Scrophularia umbrosa iridoids 122 scutalpins 247 scutedrummonin 247 Scutellaria albida iridoids 123 monoterpenoids 507 Scutia buxifolia cyclopeptide alkaloids 80 scutianine-J 77 scutianines 79 79-80 scytophycin 462 Sebastes spp.fatty acids 164 sebiferine 400 sebiferine methiodide 402 Secale cereale brassinosteroids 3,4 secalosides iii(5) secalosides iii(5) secasterone 2 3 structure 2 synthesis 382 secoadociaquinones 279 secoakuammilan 566 8,14- secoandros tane oxidation 375 14,15-secoandrost-4-en-3-ones, crystal structure 378 secoaromadendrane 157 secoberberines 393 secobriarellin 285 secobryononic acid 672 secocadinane 130 secocaryophyllene 150 9,l l-secocholest-5-en-9-one-~, 1 1 -diol 22,23-methylene-23,24-dimethyl- 286 5,lO-secocholest-I( lO)-en-5-ones cyclization 375 5,lO-secocholest-1(lO)-en-%-yl acetate 5-oxo- irradiation 375 3,4-secocycloartanes iv(2) 16,17-secodammarane 665 secodine demethoxycarbonyltetrahydro- 573 synthesis 575 secoepiraikovenal 158,263 secofascaplysin synthesis 420 secogalioside 10-deoxy- 509 secohomoaromoline 390 secoiridoid glycosides 507 secoiridoids biosynthesis 123 secoisobryononic acid 672 secoisolariciresinol 43,45 secoisolariciresinol 4”-O-methyl-3’-O-demethyl- secojollyanine 390 Subject index 1-37 secolinarioside 508 secologanic acid 124 secologanin biosynthesis 364 3,4-secooleana-4(23) 18-dien-3-oic acid 669 secotetrandrine 390 secoxyloganin 123 securamines 419,420 Securflustra securifrons tryptamines 420 Securigera spp.coumarins 465 securines 420 sedacryptine synthesis 644 sedamine synthesis 642 sedanenolide 89 sedoheptulose 7-phosphate 445 sedridine 641,642 Sedum stenopetalum sarmentosin 84 segetalineE 41 6 segetalins 41 6 selina-3,11-dien-9-01 synthesis 153 a-selinene 153 p-selinene 153 sellowiine 565 senbusine 14-0-acetyl- 192 senbusine A 192 Senecio alloeophyllus sesquiterpenes 155 Senecio aquaticus pyrrolizidine alkaloids 65 8 Senecio callosus pyrrolizidine alkaloids 658 Senecio chrysocoma pyrrolizidine alkaloids 658 Senecio densiflorus sesquiterpenes 153 Senecio integrifolius pyrrolizidine alkaloids 65 8 Seneciojacalensis pyrrolizidine alkaloids 658 Seneciojacobaea pyrrolizidine alkaloids 87 Senecio linifolius pyrrolizidine alkaloids 658 Senecio macedonicus sesquiterpenes 155 Senecio mulgediifolius pyrrolizidine alkaloids 658 senecionine 658,659 determination 658 v(3) Senecio othonnae pyrrolizidine alkaloids 658 Seneciopalmensis sesquiterpenes 150 Senecio pseudaureus pyrrolizidine alkaloids 65 8 Seneciopseudo-orientalis pyrrolizidine alkaloids 658 Senecio pterophorus pyrrolizidine alkaloids 658 Senecio racemosus pyrrolizidine alkaloids 658 senecioracenine 658 Senecio schweinfurthii pyrrolizidine alkaloids 657 658 Senecio streptanthifolius pyrrolizidine alkaloids 658 Senecio triangularis pyrrolizidine alkaloids 658 Senecio vernalis pyrrolizidine alkaloids 658 Senecio vulgaris alkaloids 658 homospermidine biosynthesis v(6) pyrrolizidine alkaloids 657 seneciphylline 658 seneciphylline acetyl- 658 seneciphylline N-oxide 658 senegasaponins 672 senegins 672 senkirkine 657,658 septicine 21,619 sequoyitol 90 serine isotope-labelled synthesis 21 2-214 serine P-lactamases mechanism 3 10 serotonin 422 serpentene biosynthesis 543 serratene aldehyde 676 1-38 Natural Products Reports 1997 Serratia liquefaciens monoterpenoids 505 sesquiterpenes 157 Serratia marcescens P-lactamases 3 10 Sinularia sandensis metabolites 281 Serratia spp.fatty acid biosynthesis 336 Sinularia spp. metabolites 281,283 semcorone 350 sinulariolone 252 282 sermlatoside 507 Siphonaria zelandica polyketides 553 Serum acre piperidine alkaloids 641 siphonarins 553 sesame seeds antioxidative properties 45 Siphonodictyon coralliphagum sesamin synthesis 56 metabolites 278 sesamin dihydro- synthesis 54 sesquiterpenoids 147 sesaminone 52 sirenin 148 sesamolin NMR 54 Sitobion avenae nepetalactone 85 sesangolin NMR 54 sitosterol 1 seselin synthesis 468 p-sitosterol biosyn thesis 594 seselin 3 ’-epox yangelol yloxy-Skimmia caureola quinoline alkaloids 606 4’-acetoxy-3’,4’-dihydro-,467 Skimmia laureola triterpenoids 662 Seseli sibiricum coumarins 466,468 skimmianine 11 14,605 606 sesquicamphane 148 slaframine 21,619 sesquichamaenol synthesis 149 slaframine N-acetyl- 22 sesquimarocanols 69 SM-5887 101 sesquipinane 148 Srnenospongia aurea fatty acids 165 sesquipinsapols 69 Smyrnium perfoliatum coumarins 465 sesquiterpenoids 125-133 145-162 sodwanones 281,675 sessein 249 soladulcidine 198 sesterterpenoids 141 solamargine 199-200 200 Setaria italica coumarins 466,472 solamargine N-hydroxy- 199-200 setosusin iv(2) 15,16-seco-22aH,25PH-solanida-5,14-dien-sfondine synthesis 470 3P-ol O-P-D-glucopyranosyl-shanziside methyl ester 6’-0-benzoyl- 508 (l+)-P-D-xylopyranoside 197 shengmanol la-hydroxy- 663 solanidine 202,626 shidasterone synthesis 382 solanidine N-oxides mass spectra 373 shikimate dehydrogenase 444 solanine 83 gene 444 a-solanine 202 shikimate pathway Solanum abutiloides alkaloids 199 metabolites 366 Solanum aviculare alkaloids 201 unusual variants 433452 Solanum robustum alkaloids 199-200 shikimic acid 5-deoxy-5-amino- phenazine Solanum spp.steroidal alkaloids 83 biosynthesis 448 Solanum triste alkaloids 200 shikimic acid v(3) Solanum tuberosum shinanallylol 470 diterpenoids 136 shinonomenine 200 HMG-CoA reductase 1 12 shionane 675 Solanum vestissimum monoterpenoids 485 shionoside-C 498 solasidine N-hydroxy- 200 shizukaols 153 solasodine 202 6-shogaol 90 solasonine 199-200,200 sialyl Lewis X 99 solenopsin A 643 sibiricin stereochemistry 468 Solenopsis invicta piperidine alkaloids 643 sibirine 647 Solenostemon monostachys monoterpenoids, siderin acetate 7-demethyl- 472 48 1 Sideritis athoa monoterpenoids 48 1 solenposin-A 64 1 Sideritis hispida monoterpenoids 48 1 Solidago canadensis monoterpenoids 48 1 Sideritis massoniana coumarins 466,472 Solidago gramin ifolia Sideritis romana monoterpenoids 48 1 monoterpenoids 48 1 Sideroqlon foetidissimum oleanane sesquiterpenes 149 saponins 672 Solidago rugosa diterpenoids 249 sideroxylosides 672 Solidago virgaurea saponins 672 siechuantine 198 sollasin A synthesis 146 Silene jenisseensis saponins 672 songarosaponins 672 Silene rubicunda oleanane saponins 672 songoramine 19 1 silphinane 150 songorine 191 192 simonsinol 69 sonomolides 248 simulansamide 396 Sophora japonica saponins 672 physiological effects 396 sophoramine 34 simulansine 606 608 sophoranol 629 sinigrin 90 Sophora viciifolia alkaloids 34 sinoacutine 400 sophoridine 34 sinococculine 402,404 Sorangium cellulosum sinomendine 399 chivosazoles iv(6) sinomenine 0-benzyl- 401 polyketides 524 sinugibberol 252,281 Sorghum bicolor sinulariadione 28 1 dhurrin biosynthesis 366 Sinularia dissecta metabolites 283 diterpenoids 137 Sinulariaflexibilis sorgolactone 92 cembranes 252 soulattrolide 465 metabolites 28 1 synthesis 470 Sinularia gibberosa Souliea vaginata triterpenoids 663 cembranes 252 soybean oil hydrogenation 173 metabolites 281 Spaeranthus indicus cyclopeptide alkaloids Sinularia maxima 80 diterpenoids 254 sparteine 33 34 35,629,630 metabolites 28 1,283,286 enantioselective transformations.63 1-633 sparteine 2-cyano-2-methyl- 36 Spodoptera frugiperda fatty acid sparteine 2-cyano-2-phenyl- 63 1 biosynthesis 35 1 sparteine 11,12-dehydro- 34,629 Spodoptera littoralis sparteine dehydro- 34,629 alkaloids 658 sparteine 2,13-dioxo- 63 1 diterpenoids 246 sparteine dioxo- 34 fatty acid biosynthesis 349 sparteine 12a-hydroxy- configuration 63 1 phenolic metabolites 83 sparteine 13a-hydroxy- 34 phenolics 87 sparteine hydroxy- 34 plant phenolics 84 sparteine 17-oxo- 34,629,630 terpenoids 86 sparteine alkaloids 32-37,628-633 Spodoptera litura analysis 628 limonin 89 chemical ecology 628-630 phenolics 87 chemotaxonomy 628-630 Spodoptera urolepsis diterpenoids 247 detection 628,629 sponges metabolites 267-281 isolation 629 Spongia agaricina metabolites 287 occurrence 628 Spongionella gracilis metabolites 279 spectroscopy 630-63 1 Spongosorites spp.metabolites 275 structures 630-631 Sporothirixflocculosa fatty acids 164 synthesis 63 1 Sporothirix rugulosa fatty acids 164 sparteine perchlorate 2-cyano-2-methyl- 24c-squalamine 294 631 synthesis 380 spartioidine 658 squalamine 294 spartioidine acetyl- 658 squalamine desulfate 294 Spartium junceum alkaloids 34,35 synthesis 382 spatane 254 squalene 91 spat-13( 14j-ene biosynthesis 222 591 592 17,18-epoxy-5,16-dihydroxy-,265 biosynthesis from presqualene Spathelia glabrescens squalene diphosphate v(2) triterpenoids 66 1 squalene 2,3-oxido- cyclisation 661 spathulenol 13-hydroxy- 157 squalene epoxide cyclization 373 Spatoglossum pacificurn fatty acids 166 squalene triterpenoids 661-662 speciophylline isomerization 563 squalestatins 547 speciosine 404 Squalus acanthius metabolites 294 spegatrine 565 SS-228Y 453 spermidine homospermidine biosynthesis SS20846A 642 v(6j stachybotrins 461 spermostrychnine 569 Stachybotrys p-1839 sesquiterpenoids 146 spermostrychnine N-deacetyl- 568 Stachybotrys spp.stachybotrins 46 1 Sphaceloma spp.gibberellin biosynthesis Staphylococcus aureus 234 cyclopeptide alkaloids 79 Spheciospongia cuspidifera fatty acids 166 lipases 178 spheroidenone v(3) Staphylococcus carnosus isopentenyl sphingosine 267 diphosphate 113 spiciferinone 549 iii(5) Staphylococcus spp. fatty acid biosynthesis spicifemin 549 336 spiciferones 549 Stauranthus perforatus coumarins 466,467 Spilanthes acmella monoterpenoids 48 1 staurosporine Spinacea oleracea biosynthesis v(6) fatty acid biosynthesis 347 iv( 1) gibberellin biosynthesis 226 synthesis 424 spinosine 392 stealthin C v(3) Spiraea japonica alkaloids 194 stearic acid 18-fluoro-9,10-dihydroxy-, spiramines 194 synthesis 172 spiramycin 104 stearic acid 10-hydroxy- 178 Spirastrella cunctatrix metabolites 279 stearic acid hydroxy- synthesis 173 Spirastrella inconstans metabolites 267 stearic acid 10-keto- 178 spirobenzylisoquinolines,394 stearidonic acid 164 spirobicyclo[ 3.1 .O]hexane X-ray structure steganacin 44 373 steganangin 44 spirobrassinin biosynthesis 365 steganone 62 spirobrassinin 1-methoxy- 93 stegobinone biosynthesis 350 spirofomabuxine iii(4) Stegobium paniceum fatty acid biosynthesis spirojatamol synthesis 158 350 spirolides 288 Stellaria dichotoma tryptamines 41 5 spiro{oxathiolane-2,2’-dihydrotetrazoles] stellarines 415 synthesis 171 Stellera chamaejasmoside coumarins 466 spiropiperidine alkaloids 646-647 473 5a-spirosolane 3p-arnino- 200 Stemmadenia obovata monoterpenoid indole 5-spirosolene 3P-amino- 200 alkaloids 559,578 22aN-spirosol-5-en-N-01 stemofoline synthesis 653 3p-{ 0-a-L-rhamnopyranosyl-Stephania cepharantha morphine alkaloids ( 1+2)-0-[a-~-rhamnopyranosyl-400 ( 1+4)-~-~-glucopyranosyloxy} - Stephania sutchuenensis morphine alkaloids 200 40 1 Spodoptera alpha diterpenoids 247 stepholidine pharmacological effects 393 Spodoptera drummondii diterpenoids 247 sterculic acid dihydro- biosynthesis 343 Spodoptera exigua sterigmatocystin 547 azedarachin C 89 sterigmatocystin 0-methyl- 547 sedanenolide 89 stembergine 304,305 Subject index steroids alcohols reactions 374 alkenes reactions 374 alkoxymethylcarbonates synthesis 375 carbonyl compounds reactions 375 cyclic acetals cleavage 375 5,7-dienes synthesis 374 3,17-diones heat of formation 375 epoxides Tactions 374 4-fluoro-A -3-keto synthesis 375 heterocyclic partial synthesis 383 hydroxylation artificial P450 v(5) 1-0x0- reduction 375 partial synthesis 373-386,376-383 photochemical reactions 375 physical properties 373-374 polyhydroxy- NMR 373 polyhydroxylated tandem mass spectrometry 373 reactions 3 73-3 86,374-3 76 rearrangements 376 remote functionalization 375 spectrosopy 373-374 te trahy dropyrany 1 ethers cleavage 375 A5-steroids 3-hydroxy- oxidation 374 A16-steroids 17-iodo- synthesis 374 sterols biosynthesis 593 sterols 4a-methyl- 455,458459,459 sterols 1~-oxo-,cholesterol biosynthesis 373 stevensine 637 Stevia rebaudiana diterpenoids 136 Stevia serrata sesquiterpenes 150 Stevia subpubescens diterpenoids 250 Stevia viscida sesquiterpenes 150 steviol 136 Stigmella malella pheromones 86 stilbene biosynthesis genes 552 stilbericoside 122 Sroechospermum marginatum diterpenoids 254 metabolites 265 stolonolides 286 streptamine 2-deoxy- biosynthesis 370 Streptanthus polygaloides nickel hyperaccumulation 86 streptazolin biosynthesis 544 streptenol D 544 Streptomyces aerioufer isopentenyl diphosphate iv( 1j Streptomyces albulus polyketides 543 Streptomyces antibioticus clavam biosynthesis 329,367 esmeraldins 446 phenazines 448 polyketides 535 valclavam 3 13 Streptomyces avermitilis avermectins 102 polyketides 537 Streptomyces bernensis beminamycin biosynthesis 370 Streptomyces carzinostaticus neocarzinostatin lo4 polyketides 541 Streptomyces cattleya fluoroacetate biosynthesis v(4j fluorothreonine biosynthesis v(4 j Streptomyces chromofuscus alkaloids 627 Streptomyces cinnamonensis pol yketides 540 Streptomyces citricolor aristeromycin biosynthesis 369 Streptomyces clavuligerus clavams 309 clavulanic acid biosynthesis 320 367 gene libraries clavulanic acid biosynthesis 324 p-lactamases 3 11 metabolites 3 14 Streptomyces coelicolor glucose kinase gene 444 polyketides 526,531,534 Streptomyces collinus ansatrienin 445 ansatrienins 433 cyclohexyl fatty acid biosynthesis 437 enzymology 436 polyketides 536,543 Streptomyces cyaneogriseus pol yketides Streptomyces cyanogenus polyketides 532 Streptomycesfradiae polyketides 532,534 Streptomyces glaucescens polyketides 526 tetracenomycinC 528 Streptomyces griseojlavus mescengricin iv(4) Streptomyces griseus aplasmomycins 453 P-lactamases 3 1 1 Streptomyces hygroscopicus bisindole alkaloids 424 clavamycin 3 13 geldanamycin 440 polyketides 536 validamycin 445 Streptomyces jumonjinensis clavulanic acid 3 12 clavulanic acid biosynthesis 322 gene libraries clavulanic acid biosynthesis 324 Streptomyces katsurahamanensis clavulanic acid 3 12 clavulanic acid biosynthesis 322 gene libraries clavulanic acid biosynthesis 324 Streptomyces lactamdurans P-lactamases 31 1 Streptomyces lavendulae arteether 149 mimosamycin 462 mitomycin 445 Streptomyces lipmanii clavulanic acid biosynthesis 322 p-lactamases 3 11 Streptomyces longisporojlavus bisindole alkaloids 424 polyketides 541 Streptomyces murayamaensis 3-amino-4-hydroxybenzoic acid iv( 1) 4-hydroxy-3-nitrosobenzamide,446 kinamycin biosynthesis 370 kinamycin C v(3) murayaquinone v(3) polyketides.532 Streptomyces nitrosporeus quinoline alkaloids 607,609 Streptomyces nodosus asukamycin 434 Streptomyces olivaceus P-lactamases 3 1 1 pyrrolizidine alkaloids 653 Streptomyces phaeochromogenes polyketides 53 1 Streptomyces rimosus oxytetracycline 528 Streptomyces roseofulvus pol yketides 526 Streptomyces sioyaensis altemicidin 453 Streptomyces spp.epicubenol 128 fatty acid biosynthesis 336 lignans 52 54 metabolites 260 phenazines 446,447 piperidine alkaloids 642 polyenes 106 polyketides 543,544 tryptamines 416 Streptomyces staurosporeus staurosporine iv( 1) 1-40 Natural Products Reports 1997 Streptomyces tendae nikkom ycin biosynthesis 368 Streptomyces tsukubaensis polyketides 536 Streptomyces verticillus bleomycin 104 Streptomyces violaceoniger polyketides 532 Streptomyces virginiae fatty acid biosynthesis 353 polyketides 545 Streptomyces viridochromogenes indole alkaloids 4 13 Streptomycetaceae marine secondary metabolites 453 streptomycetes fatty acid biosynthesis 342 polyketides 525 streptomycin 525 streptothricin F biosynthesis 328 streptovaricin biosynthesis 44 1 Streptoverticillium baldacii polyketides 536 Streptoverticillium blastmyceticum iridoids 51 1 Streptoverticillium eurocidium polyketides 533 strictoside biosynthesis 592 strictosidine 559 biosynthesis 364 strictosidine 5-methoxycarbonyl- 559 Striga asiatica germination 92 Striga gesneroides alectrol 92 strigol 92 strigolactones 92 strychnine 568-57 1 assay 569 synthesis 57 1 strychnobrasiline 569 Strychnos alkaloids 559 Strychnos gossweileri monoterpenoid indole alkaloids 562 Strychnos guaianensis monoterpenoid indole alkaloids 559 Strychnos ignatii monoterpenoid indole alkaloids 569 Strychnos mellodora monoterpenoid indole alkaloids 559 Strychnos mostueoides monoterpenoid indole alkaloids 569 Strychnos myrtoides monoterpenoid indole alkaloids 568 Strychnos nux vomica monoterpenoid indole alkaloids 569 Strychnos panganensis monoterpenoid indole alkaloids 559 568 580 stylocheilamide 262 Stylocheilus longicauda metabolites 262 styloguanidine 276 styloguanidine bromo- 276 styloguanidine dibromo- 276 stylopeptide 1 274 Stylophorapistillata metabolites 281 stylopine 393 pharmacological effects 393 stylopine 8-0xo- 392 stylopine chloride N-methyl- 392 Stylotella aurantium metabolites 276 Stylotella spp.metabolites 274 stypoldione 265 Stypopodium flabellif orme diterpenoids 254 metabolites 265 Stypopodium zonale metabolites 265 styraxin 44 styrene epoxidation v(4) styrene 5-methoxy- oxidation 583 styrene 4-nitro- oxidation 583 suaveoline 565 synthesis 567 Subcoccinella24-punctata quinoline alkaloids 607,610 suberitenones 28 1 Suberites spp.metabolites 28 1 suberosin demethyl- 466 subglutinols 254 subpubescensoside 250 sugar esters oviposition stimulants 91 sulbactam 317 Sulfolobus acidocaldarius geranylgerany1 diphosphate synthase 115 sulfomycin v(2) sulfoniopropionate dimethyl- 459 sulfonium compounds biosynthesis iv(5) sulfur 95 sulfur trifluoride diethy lamido- reaction with steroidal C-17 acetylenic alcohols 375 sultamicillin 317 sultams amino acid synthesis 208 Swainsona canescens swainsonine 23 Swainsona galegifolia swainsonine 23 Swainsona kingii swainsonine 23 Swainsonaprocumbens swainsonine 23 Swainsona spp.swainsonine 23 swainsonine 21,23-25,87,619,620-621 swainsonine acetonide 23 sweroside 3’-acetyl- 508 Swertia panicea iridoids 509 swertiapunimarin 509 swinholideA 270 Sym biod in iu m spp. metabolites 263 zooxanthellatoxinA 456 symphytoxide B 672 Symphytum oflicinale oleanane saponins 672 Synechocystis spp. fatty acid biosynthesis 339 Syringa josikaea secoiridoids 123 syringaresinol 44 Syringa spp. oleosides 123 Syringa vulgaris secoiridoids 123 Syzygium samarangense lupane triterpenoids 669 szovitsamine N-oxide 404 T Tabernaemontana divaricata monoterpenoid indole alkaloids 573 terpenoid indole alkaloid biosynthesis 364 triterpenes 600 Tabernaemontana eglandulosa monoterpenoid indole alkaloids 578 tabernaemontanine 565 tabernulosine 12-demethoxy- 565 tabersonine biosynthesis 365 synthesis 576 tabersonine 1 O-nitro-3-oxo- 574 tacamine demethoxycarbonyl- synthesis 579 tacamine synthesis 578 Tachypleus gigas fatty acids 164 Tadania anhelans pyrazolecarbox ylic acids iv(6) Tagetes argentina monoterpenoids 48 1 Tagetes erecta monoterpenoids 48 1 Tagetes laxa monoterpenoids 48 1 Tagetes laxa cabrera monoterpenoids 48 1 Tagetes terniflora monoterpenoids 481 taipaienine 198 Taiwania cryptomerioides diterpenoids 249 taiwanin A 51 takaosamine 194 talatisamine 19 1 talcarpine 19,2O-didehydro- 10-methoxy - 565 Tanacetum densum sesquiterpenes 156 Tanacetum dolichophyllum monoterpenoids 48 1 Tanacetum gracile monoterpenoids 48 1 Tanacetum longifolium monoterpenoids 48 1 Tanacetum spp.sesquiterpenes 157 Tanacetum vulgare dimethylallyl diphosphate 600 sesquiterpenes 157 tannagine 400 tannic acid 87 tannins 87-88 tanshinone dihydro- iv(4) tanyolide A 146 tanyolides 288 Taonia atomaria diterpenoids 245 metabolites 264 sesquiterpenes 158 Taonia lacheana diterpenoids 245 metabolites 264 sesquiterpenes 158 tarapacanols 245 tarapacol 245 taraxerane 672 taraxer- 14-ene 674 Tarchonanthus camphoratus monoterpenoids 48 1 tartronic acid caffeoyl- 84 tashiromine synthesis 36 tashironin 149 taurine 659 tauro-pinnaic acid 633 tauroside 672 taurospongin A,iii(5) taxanes 251-252 taxayunnanines 252 taxayuntins 252 taxol 133 biosynthesis 252 synthesis 25 1,499 taxol 9-dihydro- 252 taxotere 252 Taxus baccata diterpenoids 252 lignans 46 Taxus baccta lignans 48 Taxus brevifolia diterpenoids 249 hybrid lignans 70 Taxus canadensis diterpenoids 252 Taxus chinensis taxanes 252 Taxus cuspidata taxanes 252 taxuspine D 252 Taxus wallichiana monoterpenoids 505 taxanes 252 Taxus yunnanensis taxanes 252 taylorione synthesis 157 tazettine 304 306 tazobactam 318 tchibangensines lO-methoxy-4’ 17dihydro- 579 Tcm D3 531 TcmF1 531 Tcm F2 531 teasterone 1,5,6,7 biosynthesis 6 structure 2 teasterone 3-dehydro- 2 3 biosynthesis 6 structure 2 teasterone 3-dehydro-6-deoxo- 2,3,7 structure 2 teasterone 6-deoxo- 2,3,7 structure 2 teasterone 3-0XO- 3 teasterone-2-myristate 1 teasterone-3-myristate 2,3 8 structure 2 tecleaverdoornine 11 Tecoma stans iridoids 5 11 Subject index tehuetone 15 1 te1ikov inone 399 Telitoxicum krukovii aporphines 398 dioxoaporphines 399 telobine 1,2-dehydro- 390 Telosma cordata monoterpenoids 481 tembetarine 389 Templetonia biloba alkaloids 630 tenuisineA 11,ll ’-dimethoxy- 580 tenuisine A 3,3’-dioxo- 580 tenuisines 580 tenulin conversion to isotenulin 157 tephyllone 15 1 tephyllone 9-hydroxy- 15 1 tephyllone 9-0x0- 15 1 Terminalia arjuna oleanane saponins 672 Terminalia bentzoe monoterpenoids 48 1 Terminalia oblongata tannins 88 terminalin 88 termine 34 35 terminolitin 672 terpendoles 421 terpenoid compounds c5425 biosynthesis 11 1-144 terpenoid indole alkaloids biosynthesis 364-265 terpenoids 86-87 457 biosynthesis 591 terpentecin 247 terpenyl glucosides synthesis 477 a-terpinene 117,495 oxidation 488 y-terpinene 117,488 terpinen-4-01 487 4-terpineol 9 1 a-terpineol 478,487,488 reactions 492 P-terpineol 488 &terpineol reactions 492 terpinolene 120 reaction with methyl acetoacetate 489 terpyridines synthesis 498 testosterone labelled synthesis 377 testosterone 17a-methyl-6P-hydroxy- synthesis 378 testosterone 5a-dihydro- synthesis 378 testosterone 6a-fluoro- synthesis 378 testosterone 1 1 P-fluoro-5a-dihydro- synthesis 378 testosterone 5a-reductase 378 inhibitors synthesis 373 tetracenomycin 526 tetracenomycin C biosynthesis 528 tetracosa-5,9-dienoic acid 6-bromo- biosynthesis 344 tetracosanoylCoA thioester fatty acid biosynthesis 339 tetracosenoic acid biosynthesis 34 1 tetradeca-9,ll-dien-1-yl acetate biosynthesis 349 tetradecanoate 13-methyl- biosynthesis 336 tetradecanoic acid biosynthesis 343 tetradecanoic acid 13-methyl- 342 tetradec-1 1-enoic acid biosynthesis 349 tetradec-4-enoic acid 7-methoxy- 262 tetradec-9-en- 1-yl acetate biosynthesis 349 Tetradium glabrifolium quinazoline alkaloids 17,612 quinoline alkaloids 605,606 Tetradium ruticarpum quinazoline alkaloids 17 tetrahydroberberine oxidase 363 tetrangulol 53 1 tetranortriterpenoids 668-669 Tetranychus urticae terpenoids 86 Tetraphispellucida coumarins 466,47 1 tetraphylline 564 Tetraponera spp.tetraponerines v(4) tetraponerines v(4) Tetraselmis subcordiformis dimethylsulfoniopropionate,459 Tetraselmis suecica polyunsaturated fatty acids 459 1,2,4,5-tetrazine-3-alkanoateesters hexahydro-3-alkyl-6-thioxo- synthesis 17 1 tetrodotoxin 5,6,11-trideoxy- 294 tetronasin biosynthesis 535 541 tetronic acid 280 teubetonin 247 teubrevins 247 teucorymbin 247 7-epi-teucrenone 151 Teucrium alyssifolium diterpenoids 247 Teucrium betonicum diterpenoids 247 Teucrium brevifolium diterpenoids 247 Teucrium corymbosum diterpenoids 247 Teucriumflavum monoterpenoids 48 1 Teucrium heterophyllum sesquiterpenes 15 1 Teucrium pollum sesquiterpenes 15 1 Teucrium racemosum diterpenoids 247 Teucrium spp.diterpenoids 247 Teucrium yemense diterpenoids 247 teucryemin 247 teuhetenone B 15 1 teuhircoside 5-deoxy- 508 teuracemin 247 Thalassiosira spp. eicosapentaenoic acid 459 thaliberine 0-methyl- 390 thalicmidine 397 thalicoside D 672 thalictosides 664 Thalictrum minus oleanane saponins 672 tetrahydroberberine oxidase 363 Thalictrum spp. triterpenoids 664 thalifendine 8-0xo- 392 thalmeline synthesis 389 Thaumetopoea pityocampa fatty acid biosynthesis 35 1 Thea sinensis brassinosteroids 4 thebaine 401 biosynthesis 362 thebaine 6-bromo-6-demethoxy- 40 1 thebaine 6-chloro-6-demethoxy- 40 1 thebaine 6-demethoxy- 401 thebaine,6a,7a-methylenedihydro- synthesis 401 thebaine,7-thiocyanato-6-demethoxy- pharmacology 402 Theobroma cacao hydrox yacetophenones 95 theonellamides 274 Theonella spp.metabolites 270 274 278 Theonella swinhoei metabolites 270 thermopsine 33,34 Thermotoga maritima fatty acids 164 Thespesiapopulnea gossypol biosynthesis 128 Thessalia theona iridoids 84 Thevetiaperuviana iridoids 509 2-thiabicyclo[ 2.2.1 ]hepta-5-ene synthesis 49 1 thia fatty acids synthesis 17 1 thialaurates synthesis 17 1 thiamine pyrophosphate v(2) thiastearates synthesis 17 1 thiazinotrienomycins 434 thienamycin 309 3 1 1 structure 3 1 1 Thiocystis violacea fatty acid biosynthesis 339 thiolactomycin fatty acid synthase inhibition 337,338 thiomarinols 259 thiophene fatty acids synthesis 171 thiostrepton biosynthesis 370 Thlaspi montanum nickel hyperaccumulation 86 Thorectandra choanoides diterpenoids 245 metabolites 279 threonic acid 235 threonine biosynthesis v(6) isotope-labelled synthesis 212-214 threonine fluoro- biosynthesis v(4) threonine 4-hydroxy- v(2) thromboxaneA2 biosynthesis 353 thromboxanes biosynthesis 35 1 thujane monoterpenes biosynthesis 124 thujanes 505 Thuja occidentalis lignans 48 monoterpenoids 48 1 a-thujene 9 1 reactions 505 thujone reaction with sulfuryl chloride 505 thujopsane 148 thujopsenol epoxide 148 thunaloside 122 509 Thunbergia alata capensioside 122 fatty acid biosynthesis 348 iridoids 509 monoterpenoids 507 thuriferic acid 59 thymol biosynthesis iv(5) hydrogenation 489 Thymus bornmuelleri monoterpenoids 48 1 Thymus cilicius monoterpenoids 482 Thymus decassatus monoterpenoids 482 Thymus longicaulus chaubardii monoterpenoids 482 Thymus serpylloides monoterpenoids 482 Thymus serpyllum essential oils 478 Thymus syriacus monoterpenoids 482 Thymus vulgaris monoterpenoids 117,478 thyrsenol A iii(3) thyrsiflorin 25 1 ticarcillin 309 3 I2 tifruticin 15-hydroxy-3-dehydrodesoxy-, 86 tigloyl-CoA:pseudotropineacyl transferase 360 Tigriopus californicus metabolites 263 Tillandsia recuwata triterpenoids 663 Tillandsia usneaides triterpenoids 663 Timentin 309,312 Timonius timon iridoids 509 tin allyltrimenthyl- 489 tin hexamenthyldi- synthesis 489 tin bromide trimenthyl- 489 tinosinesides 247 tinosponone 247 Tinospora cordifolia diterpenoids 247 20P-hydroxyecdysone 373 Tinospora rumphii diterpenoids 247 Tinospora sinensis diterpenoids 247 tirucallane 666 tithonin structure 15 1 tjipanazole D 424 tjipanazole F2 synthesis 425,426 tocopherols 592 toddacoumaquinone synthesis 468 toddaquinoline 11 todolactol A 52 todolactol B 57 m-toluamide N,N-diethyl- 488 p-toluquinone 84 toluquinone tetraprenyl- 245 tolytoxin 462 tomatidine 198 a-tomatine 201 tomato isopentenyl diphosphate isomerase 597 tomentolides synthesis 470 tomentoside 123,508 tomentoside 7-hydroxy- 508 Toona ciliata triterpenoids 668 toonacilin 12-deacetoxy- 668 topotecan 584 synthesis 585 Torreya taxifolia monoterpenoids 482 tortifolisine 198 tortusine 304,306 totarol 249 toxins animal plant origin 83-84 trachelogenin 44,49 trachycladine A 278 trachycladine 3 278 Trachycladus laevispirulifer metabolites 278 trachylobagibberellin 25 1 trachylobane 135 trachylobanic acid metabolism 236 Trachyopsis halichondroides metabolites 28 1 trametenolic acid 662 trametenolic acid dehydro- 662 transsylvanosides 672 tremulane 150-1 5 1 tremulenediol iv( 6) 8a-epi-tremulenolide synthesis 15 1 triacetic acid lactone 551 triacontanedioic acid 15,16-dimethyl- 164 biosynthesis 177 triacontanoic acid 15,16-dimethy1-30-glyceryloxy- 164 triacontanol 89 1,2,4-triazoline-3,5-dione, 4-phenyl- conversion into steroidal 5,7-dienes 374 Tribolium confusum lactarufinA 90 Trichilia hirta hirtin 89 Trichilia rubra triterpenoids 668 trichilinins 668 trichoacorenol 149 trichoaurantin 254 trichoaurantiolides 254 Trichocereus pachanoi oleanane triterpenoids 67 1 saponins 673 Trichoderma harzianum fatty acid biosynthesis 346 Trichoderma koningii sesquiterpenes 148 Trichoderma virens sesquiterpenes 148 Trichoderma viride cyclopeptide alkaloids 79 isoharzandione iii(3) trichodesmine 659 Tricholomu aurantium diterpenoids 254 Trichophyton vanbreuseghemii turpentine oil 478 Trichoplusia ni linalool 85 Trichosanthes bracteata fatty acids 163 Trichosanthes newifolia fatty acids 163 Trichosurus vulpecula monoterpenoids 486 trichothecane 148 trichothecene biosynthesis 133 trichothecene my cotoxins biosynthesis 126 Trichothecium roseurn trichodiol 127 trichotriol 127 tricin 89 tricyclic alkaloids hemiterpenoid 12-1 3 tridecanoic acid o-cyclohexyl- biosynthesis 437 tridecanoic acid 4,8,12-trimethyl- 164 tridecan-2-one bios ynthesis 349 tridec-4-enoic acid 13-cyclopent-2-enyl- 165 tridensane 153- 155 tridensenal synthesis 155 Tridentata marginata tridentatolA iii(2) tridentatol A,iii(2) Trididemnum cyanophorum metabolites 290 Trididemnum solidum metabolites 290 trienomycins 434 trifarane 147 trifarienols 147 Trifolium alexandrinum oleanane saponins 672 Trifolium repens phenethyl acetate 91 trifosides 672 triglycerides unsaturated deuteriation 173 trigonosides 663 trikentrin B synthesis 413 trilaurin melt crystallisation NMR 176 trilobine 390 trhyristin melt crystallisation NMR 176 25,26,27-trinordammaranes 665 trinoreremophilanes 460 triopamine iv( 1) Triopha catalinae triopamine iv( 1) triophamine iv(6) triophamine iv(6) 22,23,24-tripeibrassinolide,5 Tripterygium wilfordii diterpenoids 254 oleanane triterpenoids 671 saponins 673 sesquiterpenes 153 trisphaeridine 307 triterpenoids 66 1-679 2,3,5-trithiahexane 91 Triticum aestivum brassinosteroids 3,4 diterpenoids 136 HMG-CoA reductase 112 Trollius laxus pyrrolizidine alkaloids 658 tropaeolin 90 Tropaeolum majus chlorogenic acid 90 tropane 7~-acetoxy-3a-tigloyloxy- synthesis 648 tropane 3P-tigloyloxy- biosynthesis 360 tropane alkaloids 91,92,637-65 1 biosynthesis 359-360 tropic acid biosynthesis 359,360 tropine 3a-hydroxy- tropane biosynthesis 360 tropocin thio- biosynthesis 438 tropolones 95 Tropsentia roquensis fatty acids 166 tryprostatins 41 8 tryptamine N,N-dimethyl- 422 tryptamines biosynthesis 364 non-isoprenoid 4 15-420 tryptanthrin synthesis 61 1 Trypterigium wilfordii diterpenoids 249 saponins 673 triterpenoids 675 tryptolactone 675 tryptophan biosynthesis 433 isotope-labelled synthesis 21 5-217 tryptophan 2-bromo-5-hydroxy- synthesis 416 tryptophan 6-chloro5-hydroxy- synthesis 416 tryptophan dimethylallyl- biosynthesis 364 tryptophanase amino acid synthesis 206 tryptophan metabolites 364-366 tryptophan synthase amino acid synthesis 214 tryptoquivaline alkaloids 46 1 tscheschamine 76 tsitsixenicins 253 285 tsugicolines 150 Tu 1718B biosynthesis 329 Tubastrea faulkneri metabolites 281 1-42 Natural Products Reports 1997 tuberculostearic acid biosynthesis 340 synthesis 167 tuberine 483 tuberosinone 400 tubifolidine synthesis 569,570 tubifoline synthesis 569 570 tubifoline didehydro- synthesis 570 tubocurarine 390 tubotaiwine 568 tubulosine 395,422 tubulosine 9-O-demethyl- 395 tubulosine 0-demethyldeoxy- 395 tubulosine deoxy- 395,422 tubulosine deoxydesmethyl- 422 tubulosine 9-desmethyl- 422 tubulosine O-methyl- 395,422 Tulipa gesneriana brassinosteroids 4 Tulipa spp.tuliposides 93 tuliposides 93 tumulosic acid 3-epidehydro- 662 tunicamycin 3 14 tunicates 288-294 Turbinaria ornata fatty acids 164 turcberine synthesis 388 turkesterone 89 p-turmerone 147 turpentine oil 478 Turraeafloribunda triterpenoids 668 Turraea nilotica triterpenoids 668 Turraea spp.triterpenoids 668 tussilagine 657 658 Tussilagofa$ara pyrrolizidine alkaloids 657,658 tylocrebrine 6-demethyl- 3 1 tylopharine 7-demethyl- 90 Tylophora tanakae alkaloids 90 phenanthroindolizidine alkaloids 3 1,626 tylophorine 31,619 tylophorine 7-demethyl- 31,626 tylophorinine N-oxide 3 1 tylosin biosynthesis 535 Typha latifolia brassinosteroids 4 typhasterol 1,5,6,7 biosynthesis 6 structure 2 typhasterol 3-dehydro-6-deoxo- 7 typhasterol 6-deoxo- 2,3,7 structure 2 tyramine N-feruloyl- 305 tyrosinases sequence and structure vi(6) tyrosine biosynthesis 433 decarboxylases benzy lisoquinoline alkaloid biosynthesis 361 tyrosine N-hydroxy- biosynthesis 366 tyrosine isotope-labelled synthesis 21 2-214 tyrosine hydroxylase hydroxylation v(3) U ubiquinol 14 ubiquinone-8 biosynthesis 593 ubiquinones 592 biosynthesis v(6) udoteatrial synthesis 5 11 uhdoside-A 508 uhdoside-B 508 uleine 572-573 Ulva pertusa fatty acids 165 umabanol iii(5) umbelliferone 95 determination 465 Umbellularia californica allelopathy 92 fatty acid biosynthesis 347 monoterpenoids 505 umbellulone 505 Subject index uncargenin C 674 uncargenins 674 Uncaria elliptica triterpenoids 674 Uncaria rhynchophylla monoterpenoid indole alkaloids 559 triterpenoids 674 Uncaria thwaitesii triterpenoids 674 uncaric acid 674 uncarine F isomerization 563 undecanoic acid o-cycloheptyl- biosynthesis 438 undecanoic acid 1 1-cyclohexanyl- 341 undecanoic acid a-cyclohexyl- biosynthesis 437 undecanoic acid lo-( 1,3,2-diaza- phospholidin-2-one)- methyl ester synthesis 171 undecanoic acid lo-( 1,3,2-oxaza- phospholidin-2-one)- methyl ester synthesis 171 undeca-2,4,6,8-tetraene, 3,5-dimethyl-7-ethyl- biosynthesis 350 undeca-2,4,6,8-tetraene, 4,6,8-trimethyl- 350 undulatine 304 305 untenone 270 7-epi-uprolide C acetate 282 8-epi-uprolide A acetate 282 8-epi-uprolideB 282 uprolide A acetate 282 uprolide B 282 uprolide C 282 uprolide D 282 uprolide E acetate 282 uprolide F diacetate 282 uprolide G acetate 282 uprolides 252 uracil NJV-dimethyl- 85 urdamycin biosynthesis 532 urease mechanism vi(6) uracanic acid biosynthesis 369 Urolepis hecatantha sesquiterpenes 145 ursa-l2,19dienes 674 ursa-l2,18-dien-28-oic acid 2a,3P,23-trihydroxy- 674 ursane triterpenoids 674-675 urs- 12-ene-3a,24-diol 674 urs- 12-ene-2P,3P,22a-triol 674 urs- 12-ene-2P,3P,28-triol 674 urs- 12-en-24-oic acid 2a,3a-dihydroxy- 674 urs- 12-en-28-oic acid 3p 19a,24-trihydroxy- 675 urs- 12-en-28-oic acid 3P,6P 19-trihydroxy- 674 urs- 18-en-27-oic acid 3P-hydroxy- 674 18a-ursolic acid 674 3-epi-ursolic acid 675 ursolic acids pharmacology 661 Urtica dioica fatty acids 165 sesquiterpenoids 145 usambanoline 396 Ustilago maydis HMG-CoA reductase 1 12 Utricularia vulgaris iridoids 509 V Vaccaria segetalis tryptamines 4 16 vaccenic acid detection NMR 176 vaccenoic acid biosynthesis 35 1 cis-vaccenoyl ACP 336 vaganins 199 Vahlia capensis oleanane triterpenoids 669 vakhmatine 192 vakhmatine 13-O-acetyl- 192 valclavam 3 13 biosynthesis 329 valdiate 509 valerane 151-153 valerate 2-amino-5-hydroxy- clavulanic acid biosynthesis 320 Valerianafauriei sesquiterpenes 157 Valeriana jatamansi valerianoid A iii(5) Valeriana oficinalis sambucifolia iridoids 509 valerianoid A iii(5) validamycins 445 valine isotope-labelled synthesis 205-2 12 valiolone 445 vallesiachotamine synthesis 562 Valsa ambiens fatty acids 165 varacin 290 variabilin 280 variabilin 1 I-methyloctadecanoate 280 varicin 290 vasconine 304 vasconine 8-O-demethyl- 304 305 vasicine 16 17,613 vasicine deoxy- 17 vasicine dihydrodeoxy- 613 vasicinol 613 vasicinone 16 613 vasicinone deoxy- 61 3 vasicinone 7-methoxy- structure 61 3 vasicol 16 vasnetine 16 vebilocine 615 velleral 130 vellerol 130 Velloziaflavicans diterpenoids 248 Vellozia magdalenae bismagdalenic acid iii(3) Vepris bilocularis acridone alkaloids 6 15 quinoline alkaloids 606,608 Vepris heterophylla quinoline alkaloids 1 1 veramivirine 200 Veratrum album steroidal alkaloids 84 Veratrum lobelianum sesquiterpenoids 145 Veratrum oblongum alkaloids 200 Veratrum viride alkaloids 200 verbanone 494 Verbascum nigrum iridoids 509 Verbascum songaricum oleanane saponins 672 verbenol synthesis 494,495 verbenone reduction 494 synthesis 495,496 vermaline 12P-hydroxy- 200 vernodanol 8-desacyl- 15 1 vernolepin synthesis 151 vernolic acid 166 179 Vernonanthura amplexicaulis diterpenoids 250 Vernonia auriculifera sesquiterpenes 15 1 Vernonia galamensis fatty acids 166 lipases 178 Verongula gigantea fatty acids 165 Veronica anagallis-aquatica iridoids 509 verrucosanes 247,254 versicolorin B 546 versicolorone hydroxy- 546 versiconal hemiacetal acetate 546 vertebrates fatty acid biosynthesis 35 1-353 verticillin A 427 Verticillium dahlia sesquiterpenese 149 verticinone 198 vertine demethyl- 627 vetiselinene synthesis 153 vetisperane 153 vetispiradiene 125 Vibrio anguillarum anguibactin 455 Vibrio harveyi flavin reductase P v( 1) Viburnum lantana iridoids 509 Viburnum spp.monoterpenoids 507 Viburnum suspensum iridoids 509 Viburnum tinus monoterpenoids 507 Viciafaba brassinosteroids 4 Vicoa indica oleanane triterpenoids 671 vicogenin 67 1 Vigna anglaris brassinosteroids 5 Vigna radiata brassinosteroids 4 Vigna unguiculata alectrol 92 saponins 672 villalstonine 580 villatamines 290 vilmoridine 192 vilmorrianone 192 vinblastine synthesis 580 vinblastine 5’-noranhydro- 580 vincadifformine synthesis 57 1 576 578 vincadifformine 19-ethoxycarbonyl- 19-demethyl- synthesis 576 vincadifformine ~-oxo-,synthesis 576 vincadifformine 16-~hloroindolenine 5-c yano- rearrangement 57 5 vincamine 577-578 biosynthesis 365 synthesis 578 vincamine 11 -methoxy- synthesis 578 Vinca minor vincamine biosynthesis 365 vincine synthesis 578 vincotene 31 vindoline biosynthesis 365 vindoline deacetyl- biosynthesis 365 vindoline electrochemical oxidation 575 vinervinine 16-decarbornethoxy- 568 vinervinine decarbomethoxy-2,16-dihydro- 568 vinorine biosynthesis 365 violacein biosynthesis 364 Viola prionantha coumarins 466,470 viranamycins 535 virantmycin 609 virescenine 192 Virginiae buanolide A biosynthesis 353 virginiamycins biosynthesis 370-37 1,449 virginiamyin MI 545 viridicatin 11 607 viriolin 67 Virola michelii lignans 52 viscidines iii(6) vitamin B 1 biosynthesis v(5) vitamin B6 biosynthesis v(2) vitamin D analogues synthesis 373 partial synthesis 383 vitamin D3,25-hydroxy- monoglucuronides synthesis 383 Vitex agnus-castus iridoids 509 monoterpenoids 482 Vitex canescens alkaloids 200 pinnatasterone 89 Vitex cannabifolia monoterpenoids 507 Vitex limonifolia diterpenoids 245 Vitex negundo monoterpenoids 507 Vitex rotundifloria diterpenoids 246 Vitis vinifera isopentenyl diphosphate transport 600 phytoalexins 95 polyketides 552 vittatine 304 306 vittatine 1I-hydroxy- 304 305 voacangine 578 voachalotine NMR 565 voacristine 578 voafinidine 573 voafinine 573 voafinine N-methyl- 573 voalenine 573 vomilenine 565 biosynthesis 365 voucapan- 17P-oic acid 6a,7P-dihydroxy- 248 vularolide 157 vulgarolide synthesis 157 w waihoensene iii(5) Walsuria piscidia triterpenoids 666,668 warburganal synthesis 147 Wedeliapaludosa monoterpenoids 482 Wedelia trilobata monoterpenoids 482 wiedendiol A synthesis 147 wiedendiols 147,278 wikstromol 49 wilforol A 673 wilforol B 673 wilforol C 671 wilforol D 673 wistariasaponins 672 Wisteria brachybotrys oleanane saponins 67 2 woorenogenin 66 wyerone synthesis 170 wyerone dihydro- synthesis 170 X xanthane 155-1 57 2-epi-xanthanol 15-chloro- 157 Xanthium strumarium sesquiterpenes 157 Xanthornonas campestris sesquiterpenese 149 xanthoquinodins 55 1 xanthotoxin 88 xanthotoxin-5-sulfonamides,synthesis 473 xanthoxin 132 Xanthoxylum nitidum neolignans 67 xanthurenic acid 6 10 xanthyletin crystal structure 467 xanthyletin 3’-hydroxy- 467 Xenia elongata diterpenoids 253 metabolites 285 xeniaethers 285 Xenia spp.metabolites 285 xeniatine A 285 xeniatine A epoxide 285 xenicane 253 xeniolide-A 9-deoxy- 285 xeniolide-B deoxy- 253 xeniolide-B 9-deoxy- 285 Xenorhabdus bovienii indole alkaloids 41 3 Xenospongia wiedenmayeri metabolites 278 Xesetospongia spp. metabolites 270 xestobergsterol C 281 xestomanzamineA 274 xestomanzamines 274 xestoquinone biosynthesis 545 xestoquinone 15-chloro- 14-hydroxy- 279 xestoquinone 14-chloro- 15-hydroxy- 279 xestoquinone 14-methoxy- 279 xestoquinone 15-methoxy- 279 Xestospongia exigua polyketides 545 Xestospongia ingens metabolites 274 Xestospongia supra polyketides 545 Xestospongia spp.fatty acids 171 metabolites 270,274,279,28 1 Xestospongia wiedenmayeri sesquiterpenoids 147 xuxuarineAa 673 xuxuarineAP 7’,8’-dihydro- 673 Xylaria mali piliformic acid iv(4) Xylaria spp. fatty acids 165 Xylopia aethiopia termite antifeedant activity 90 Xylopia aethiopica diterpenoids 250 Xylopia frutescens diterpenoids 250 Xylopia nitida monoterpenoids 482 xylopine 397 pharmacology 399 xylopine 0x0- 399 xylopinine 393 D-xylulose 1-deoxy- v(2) Y Yalaha spp. coumarins 466 yangambin 44 synthesis 56 Yarrowia lipolytica fatty acid biosynthesis 346 yatein 44 yatein 4’-O-demethyl- 48 yeast isopentenyl diphosphate isomerase 595 yingzhaosu C synthesis 147 epi-yingzhaosuC synthesis 147 yixinoside A 666 yiyeliangwanosides 672 yohimbane synthesis 564 yohimbine 559-565,560 oxidative rearrangement 563 P-yohimbine 559,560 yohimbine pseudoindoxyl stereochemistry 563 P-yohimbine pseudoindoxy 1 stereochem istry 563 yomogi alcohol 485 yonarolide 283 YTR 830 318 ytramine N-feruloyl- 304 yubeiside 198 yuehchukene 424 yukocitrine 614 615 yukocitrine 4-(2-hydroxy-3-methyI- but-3-enyl)- 615 yunaconitine 192 Z zahavins 285 Zaluzania grayana sesquiterpenes 156 Zaluzianskya capensis iridoids 509 zaluzioside 509 zanthosimuline 13,608 Zanthoxylum ailanthoides norlignans 70 Zanthoxylum armatum monoterpenoids 482 Zanthoxylum bungeanum monoterpenoids 482 Zanthoxylum chalybeum quinoline alkaloids 606 Zanthoxylum chaylbeum aporphines 398 benzylisoquinolines 389 berberines 392 Zanthoxylum dissitum quinoline alkaloids 606 Zanthoxylum heitzii lignans 47 Zanthoxylum integrifolium quinazoline alkaloids 6 11 tryptamines 416 Zanthoxylum nitidum quinoline alkaloids 606 Zanthoxylumpetiolare lignans 54 Zanthoxylum regnellianum quinoline alkaloids 606 Zanthoxylum rhetsa monoterpenoids 486 Zanthoxylum schinifolium coumarins 465,466,470,472 furoquinoline alkaloids 609 Zanthoxylum simulans benzophenanthridines 396 1-44 Natural Products Reports 1997 quinoline alkaloids 11 606,608 Zanthoxylum spp.lignans 45 Zanthoxylum usamharense aporphines 398 benzophenanthridines 396 benzylisoquinolines 389 berberines 392 quinoline alkaloids 11 606 zaragozic acid A 547 Zea mays brassinosteroids 4 5 diterpenoids 137 138 germination 92 gibberellin biosynthesis 222 Zhumeria majdae diterpenoids 249 Zingiber oficinale monoterpenoids 482 zinnacitrin 151 Zinnia citrea sesquiterpenes 15 1 zizaene 149 zizyotin 666 Zizyphus jujuba cyclopeptide alkaloids 80 fatty acids 163 Zizyphus lotus cyclopeptide alkaloids 80 Zizyphus mauritiana tryptamines 416 Zizyphus mucronata cyclopeptide alkaloids 80 Zizyphus nummularia cyclopeptide alkaloids 80 Zizyphus oenoplea triterpenoids 666 Zizyphus rugosa cyclopeptide alkaloids 80 Zizyphus sativa cyclopeptide alkaloids 80 Zizyphus spina-christi cyclopeptide alkaloids 80 Zizyphus vulgaris cyclopeptide alkaloids 80 Zofiela marina zofimarin 460 zofimarin 460 Zonocerus variegatus pyrrolizidine alkaloids 83 zooxantellatoxins 263 zooxanthellatoxin A 456 Zopfiella marina zopfinol 460 zopfinol 460 zygadenine 3-acetyl- 84 zygadenine angeloyl- 200 zygadenine vanilloyl- 200 zygadenine veratroyl- 200 Zygomonas mohilis isopentenyl diphosphate 113 Zygophyllum album triterpenoids 675 Zygophyllum coccineum triterpenoids 675 Zygophyllum dumosum triterpenoids 675 zygophyloside F 675 Zyzzyafulginosus makaluvic acids iv(2) Zyzzyafuliginosa metabolites 274 Subject index 1-45 Index of authors cited Upright numerals show the page on which a reference appears litalic characters indicate the reference number on that page Abu-Zarga M.82/42 Agrawal S. 255110 2971136 2991281 Akisue G. 5211746 A Abu Zarga M. H. 4101439 Agren L. 971132 Akisue M. K. 5211746 Achari B. 1811184 6781134 Aguiar Z. 981186 Akita H. 159180 3001335 336 Acharyulu P. V. R. 1611215 Aguilar M. I. 159172 Akiyama E. 651188 Aach H. 1431211 241150 521I667 Aguinaldo A. M. 1601183 Akiyama M. 1601192 Aakeson J. 4091304 Achenbach H. 731141 7412 71 272 Agullo C. 5211698 Akiyama S. 4511102 Aal M. A. 5151206 676140 677168 Agyin J. K. 384176 Aklonis C. A. 3331204 Aamundstad. T. 4081235 395 400 Achola K. J. 5161243 Agyin K. 384177 Aknin M. 1811216 Aarkawa Y . 3321125 Achs E. 1861623 Agzamova M. A. 676124 25 26 Akoh C. C. 1881817 818 819 857 Aaron J. J. 5181465 AchyuthaRao S. 650133 Aharoni N. 981198 199 1891909 5161282 284 285 Aarsland A.1831418. 421 Acklin P. 588129 Aharonowitz Y.,24311 91 Akpagana K. 5151141 Abacherli C. 218166 Ackman R. G. 1811183 201 Ahmad A. 82/19 Akssira M. 5191553 Abad A. 5211698 1861675 676 Ahmad F. 1831337 342 396 Akunyili D. N. 5221767 Abad J.-L. 676113 Acosta R. D. 202111 Ahmad I. 182/260 Akutagawa S. 5131.5 Abad M. J. 1621317 475184 Actis L. A. 463125 Ahmad Jr. M. S. 1831426 428 Akutsu K. 462122 Abalov A. 406145 Adachi A. 109138 Ahmad M. B. 1831394 396 405 Al-Aboudi A. 82/42 Abarca G. E. 5161226 Adachi K. 296136 4631105 4641109 407 1841431 432 443 Alam M. 463191 96. 588110 Abas S. A, 428190 Adachi Y.,3331214 Ahmad R. 1821260 Alamercery S. 5141137 Abbas S. A. 2981241 Adam G. 913 7 13 14 25. 28 29 Ahmad V. U. 1611223 650118 Alami M.5181457 Abbi J. D. 218153 38 50 10199 100 101 102 651182 6781182 6791204 Alankus-Caliskan 6781149 Abbot E. M. 2191104 3851200 677180 97 Ahmad Y.,589161 Ala-Peijari M. 1811173 1831359 Abbott F. V.. 4091295 Adam K. P. 741273 Ahmed A. A, 159153 1621303 311 Alarcon J. 1611252 Abbott T. P. 1891899 Adamczeski M. 1811218 2981177 474125 5 13/34 5 161258 Al-awar R. A. 651162 Abboud K. A.. 3011489 Adamczyk M. 3851175 Ahmed A. F. 474120 Alaya A. L. 1611213 Abburra R. E. 5161240 Adams C. M. 1601122 Ahmed M. 5151204 Al-Azizi M. M. 401102 Abd E. A, 4751113 Adams H. 5181404 5201633 Ahmed M. A. 1831404 Albanese A. 4081208 Abdalla S. 1611256 Adams J. 1801123 Ahmed S. M. 1831337 Albers-Schonberg G.. 330135 44 46 Abdallah 0. M. 401106 1611258 Adams L. 3001380 3011459 Ahmed S.P 39/58 59 Albertini A. M. 555183 303116 Adams R. P. 5151166 168 169 I70 Ahmed W. 677198 Albertini E. 650140 Abdel Aziz E.. 659133 Adams W. W. 383134 Ahmed Z. H. 5551110 Alberts A W. 356113 30 40 48 50 Abdel Sattar E. 401102 Addaemensah I. 5 151141 Ahn H. S. 159148 2991249 Albizati K. F. 5201602 65014 Abdel-Azim H. 5 161250 Addae-Mensah I. 677168 Ahn K. H. 5201630 Albone K. S. 2411103 2421104 112 Abdel-Fattah H. 635183 Addeo F. 1871728 730 Ahn K. S. 474137 Albrand M. 25511 7 Abdel-Fattah M. S. 659144 Adebajo A. C. 42716 Ahn Y. 451llI5 116 Albrecht M. 141148 6031140 Abdel-Galil F. M. 82/46 Adeboya M. O. 1821240 Ahond A. 159139 65015 Albrecht P. 3861215. 6791247 Abd-el-Ghani A, 721112 Adekenov S. M. 1621297 298 299 Ahrens H. 401150 636197 Albrizio S.2981201 Abdel-Hafez 0.M. 4751113 307 322 325 Ahsan M.. 2013 4 Albuquerque M. L. C. 4091340 Abdel-Halim 0.B. 635174 83 Adhikari S. 731156 157 180 Ahtee L. 4091354 Alcaraz M. J. 2971110 Abdel-Kader M. S. 2561106 Adibatti N. A, 650150 Ahuja J. R. 5211666 Alchanati I. 1431163 1601123 Abdul-Hajj Y. J. 3841115 Adil Q. 6191224 Aibara S. 6791237 Alder L. 1821245 Abdullaev N. D. 405113 22 23 31 Adinolfi M . 29912 78 Aidoo K. A, 3331217 Alducin E. 159185 406155 60 63 111 112 Adlard M. W. 39/21 22 635115 Aiello A. 2981235 Alencar J. W. 5151216 5161239 256 Abduilah M. I. 1861653 Adlercreutz H. 71/17 18 37 38 40 Aigner R. 475197 Alewood P. F. 405119 Abdullah R. M. 676131 41 Aihara T. 741276 Alexakis A. 1821316 Abe F. 40190 731150 971113 Adlercreutz P. 1881863 Aikens J.1851540 Alexander D. C. 333121 7 1601183 5221796 635159 60 Adlington R. M. 218169 3321128 Aimi N. 5221762 773 58814 15 27 Alexander D. L. 3851179 Abe H. 919 11 12. 17 19 20 26 178 179 193 3331211 31 Alexander M. R. 2971153 27 30 44 48 49 59 63 1431213 Adlof R. O. 1841467 468 478 Aippersbach S. 331186 Alexander S. 40513 4 24 1/47 48 1861628 630 632 633 634 Airoa J. L. 160l180 Alexeev D. 3581245 Abe I. 4291122 Adoutte A. 46212 Aitken S. M. 142163 64 84 Alford A. R. 677177 Abe M. 1441217 618169 Adriaens P. 2 1718 Aituganov K. A. 1621298 Al-Hasan R. H. 1811164 Abegaz B. 5151177 Add G. O. 677177 Aitzetmueller K. 180l108 1811155 Ah A. A. 731148 Abeles R. H. 141149 3331205 Advokat C. 4081280 156 1851576 Ah M. 6791228 356160 Adzei T. 5161229 Aiyama R. 5901133 Ali M.A, 5161299 Abeles R. H. 602162 100 Aebi J. D. 218137 Aizawa T. 12/50 Ah S. M. 2571186 Abell C. 1431207 Afaque S. 1831426 Aizdaicher N. A. 181l160 Alibes R. 513115 Abiko M. 142171 15816 Afek V. 981198 199 Aizenstein M. L. 4071201 Alihaud G. P. 3561101 Abondo R. 514186 Afifi M. S. 5221802 Aizpurua J. M. 5201644 Alikov V. B. 1621307 Abou-Mansour E. 3011447 456 Afonina 0.M. 1811188 189 Ajito K. 109168 Abou-Mour A, 514154 Aftab K. 203134 Akagi Y. 463127 Alikulov R. V. 4101440 Abouzei M. A. 5161271 Agami C. 5181468 Akahori A. 676118 19 Allais D. P. 255174 Abraham E.. 3321157 Agarwal K. 1431169 Akaji M. 5161265 5221757 Allakhverdiez A. I. 5171396 Abraham E. C. 330112 Agarwal R. 1831405 407 1841443 Akamatsu M. 2561143 Allan R. A, 96/29 Abraham E. P. 330116 6791231 Akamatsu Y.356181 Allan R. D. 4291130 Abraham J. 3841110 Agarwal S. G. 618161 Akasaka K. 1851595 Allaoud S. 5161299 Abraham S. 3581223 224 225 Agarwal S. K. 462112 5141112 Akasuka T. 981190 192 193 Allen B. E. 6031122 Abraham S. P. 463196 650159 1431206 1601192 Allen C. S. 3021494 3851198 Abraham T. W. 37119 Akazawa K. 650113 Allen D. G. 401130. 331198 Abraham W.-R. 618135 Agarwal V. 384153 Akee R. K. 2981221 Allen K. G. 603l11.5 Abrahamsson K. 463186 Agatsuma M. 2421165 Abram S. 4081265 Agelopoulos N. G. 97187 Akermark B. 1821320 Allen S. H. G. 356173 Abrams S. R. 1431186 Ageta H. 255113 6771118 6791214 Akgul A. 5151193 Allen T. 618122 3011433 Abramson N. L. 1831425 215. 222 238 245 246 Akhila A. 1431165 3841117 Allen T. M. 2981180 187 239 Abrell L.4631102 106 Aggarwal V. K. 5191549 Akiba K-Y. 5181428 2991296 2991297 3001416 428148 Abujder D. 5141108 Agharahimi M. R. 741250 5201603 Akiba S. 406171 676147 Abul-Hajj Y. J. 384187 Agno A, 4101378 404 Akimoto K. 1881869 870 871 872 Allgaier H. 450167 Abumrad N. N. 4101394 Agostinho S. M. M. 677l81 875 59011 33 Alling D. W. 4101384 Abu-Mustafa E. A, 159153 474125 AgranoK B. W. 602130 31 59 Akimoto M. 1811220 1881882 Alluri M. R. 55.5158 Aburada M.. 72150 Agrawal P. K. 11/20 2561113 Akimov Yu. A. 6781167 168 Allwine E. J. 514158 Aburaki S. 555166 38314 7 Akino H. 1611270 2991279 Almarsson O. 1881853 3581250 Index of authors cited 1-47 Almonacid L. N. 731160 Almtorp G. T. 72199 Alo B. 3011459 Alonso J. J. P. 5211699 Alonso S. J. 731160 Alonso W.R. 141111 142197 98 99 102 Alpin R. T. 3321142 Al-Rehaily A. J. 405136 Al-Said M. S. 401102 Al-Shurbaji A. 1831422 Altamini W. 406154 Altan E. 450154 Altarejos J. 159159 3001411 5 151167 Al-Tawaha C. 6781146 Altmann T. 10198 39/35 Alvarado S. I. 4751106 Alvarenga N. L. 6791209 210 Alvares-Maltha C. R. 256180 Alvarez C. 1861695 Alvarez J. G. 179123 Alvarez L. A. 3011421 423 Alvarez M. 218176 428168 Alvarez-Cisneros C. 159187 Alvarez-Manzaneda E. 1621349 Alvarez-Manzaneda E. J. 5171312 Alves R. J. 1611229 Al-Warkeel A A. M. 4071150 Al-Yahya M. A. 82122 Alzueta A. 4071190 Amagaya S. 71/19 40512 Amaike M. 5211704 Amann R. 588128 Amann T. 371131 Amano S. 2971116 117 Amano Y. 2571220 221 3001373 3 74 Amat M.588114 589158 Ambid C. 142157 602153 Ambler R. P. 330125 3321133 Ambroise L. 589196 Ambrus G. 383133 Amedio Jr J. C. 659114 Amemiya M. 555167 5561134 Amendola A. A, 4101422 Amer A. 12l100 Amico V. 25514 296181 83 297196 Amin H. M. 4101379 Amira R. 650110 Ammar A. 406154 Ammermdnn E. 82172 Amos H. E. 3919 Amputch M. A. 5181425 Amrhein N. 372157 Amundson C. H. 1871790 Amurrio D. 6361122 Amy C. M. 3581206 211 Anac O. 5111323 Anai T. 981148 Anake K. 255175 Anand R. C. 618176 Ananta I. 203149 Anantachoke C. 255175 Anastasis P. 602139 40 57 Ancel J. E. 5211709 Anday E. K. 4091340 Anders IJ. 1601154 Anderse K. J. 618122 Andersen G. 4081279 Andersen I. 372174 Andersen J.F. 555177 78 Andersen P. 1881809 Andersen R. A. 1851558 Andersen R. J. 8119 10 296177 2981180 187 196 204 239 3001409 416 3011433 428148 43/24 5561151 676147 Anderson A. J. 3571113 Anderson B. 60116 Anderson E. 4081275 Anderson I. 3321189 Anderson J. C. 97/60 Anderson J. D. 241124 Anderson J. L. 1621312 Anderson K. S. 4511119 Anderson M. G. 4511101 I03 Anderson M. S. 602179 Anderson P. E. 602168 Anderson S. K. 97157 Anderson W. A, 5161283 Anderson W. K. 39/47 Andersson I. 2431190 Andersson M. 142175 Andersson P. E. 1861665 Andersson S. M. 1841512 Ando A. 5891114 Ando C. 44919 Ando H. 38511 77 Ando K. 255156 Ando M. 1601203 1611220 2.53 Ando N . 20123 Ando T. 3581201 Ando Y. 1861638 639 641 5561163 Andoh T.6781163 Andolfi A. 981153 Andrade C. H. S. 589197 Andrade-Gordon P. 2981185 Andre G. 1851596 1891908 Andreef M. 41 11460 Andreotti A. H. 109157 Andrew E. R. 383114 Andrews C. W. 589156 Andrews D. M. 5201649 Andrews J. M. 3311111 Andrzejewska-Golec E. 5211714 Anekwe G. E. 3571124 Ang H. L. 1441238 Angenot L. 58812 5 55 Angerhofer C. K. 405135 4281104 Angennann J. 635120 Angers P. 158130 Angiolini L. 5891113 Angle S. R. 3912 Anh N. G. 741231 Anh N. H. 741239 Anil H. 6781149 186 Aniol M. 514155 Anisimov A. V. 5161294 Anisomova E. A. 5191517 Aniszewski T. 40197 118 I99 Anjaneyulu A. S. R. 731186 16011 76 1621334 18 11209 2571225 2581239 3001337 339 343 344 372 386 3011482 Anjaneyulu V.2571210 226 3001360 Anke H. 1811219 Anke T. 159141 1601154 1811227 Annand R. R. 356152 Annoura H. 2981231 Annunziata R. 428143 475198 5201591 592 6 18/30 Ansari G. A. S. 1851575 Ansari M. H. 1831396 407 426 1841431 432 1841432 Ansarin M. 371111 4071195 Anthoni U. 3001391 428169 6781199 Anthonsen T. 1851579 Antkowiack W. Z. 5201591 592 Antolic A. 5221805 Anton I. A. 4511118 Anton R. 428188 6781180 197 Antoni G. 219199 Antonian E. 1871791 Antonious M. S. 414115 Antonsen K. 4081279 Anttila U. 588122 23 Antunes 0.A. C.,256179 5181411 Anulewicz R. 383123 27 Anuradha S. 589173 Ahman J. 39/77 635144 45 Asen P. 3 511135 Aoe K. 2991297 Aoki H. 255113 450139 Aoki K. 2981226 588125 6791240 Aoki M.6771122 Aoki S. 2981181 205 Aoki T. 406143 Aoki Y. 676133 36 Aoyagi A. 405120 Aoyagi K. 141130 Aoyagi S. 39130 36 93 618144 45 46 63412 635161 62 635162 Aoyagi T. 296129 618178 Aoyagi Y. 741276 65913 Aoyama H. 677151 Aoyama T. 296129 Aoyama Y. 721118 Aparicio J. F. 450120 45 46 55315 74 555174 Apelgren L. D. 3851189 Aphaijitt S. 255121 Apparu M. 1841489 Appel H. M. 97/80 Appelberg U. 5201646 Appelqvist L. A. 7118 9 Appendino G. 2561151 153 163 164 170 185 475198 5211687 Appleford N. E. J. 1441226 2421122 Ara R. 5141108 Ara Y. 72174 Araujo Pereira M. M. M. 39113 Arai H. 427123 Arai M. 1861662 5221809 Arai T. 450136 5 161244 5201629 521I663 Arai Y. 5201634 652 6791215 238 Arakawa M.3001402 4641116 Arakawa O. 4071196 Araki S. 5171329 373 Arantes S. F. 475187 Arao K. 1601203 Arao T. 3571130 131 6781162 Arar G. 741228 Arase T. 158112 650151 52 Arasu L. 589175 Arazny Z. 405118 Arbain D. 82/45 Arbouai J. 406179 Arbuzov B. A. 5181448 Arcamone F. 109123 24 Archavlis A.. 1871713 25518 297194 Archbold R. 9811 78 Archelas A. 5161279 Archer R. A. 3851189 Archer S. 4101402 Arciniegas A. 659121 Ardisson J. 6361101 Aregullin M. 1621318 Arencibia T. 384179 Argenti L. 159177 78 Argoni D. 602154 Argyriadou N. 514181 Arias J. M. 1611260 255133 34 35 Ariga T. 450164 Arigoni D. 1421108 1871787 5161272 Arihara S. 741235 241 243 2991314 6781134 Arima M. 918 22 58 60 Arimoto H.3011420 474122 Arimoto M. 72/48 Aripov K. N. 20147 48 618162 63 Aripova S. F. 660162 Arisawa M. 33 11119 Arison B. 450144 5551102 55611 75 I76 Arison B. H. 109149 330135 46 Arison N. H. 330144 Ariza-Espinar L. 5 1511 75 I79 Armitage I. M. 356137 Armstrong D. 3851170 Armstrong D. J. 1861688 1871718 Armstrong J. A. 2012 3 4 8 1621293 333 474126 475152 66 78 677155 Armstrong M. P. 1881847 Arnason J. T. 97194 Arnaud A. 1881812 Arnaud R. 5201586 Arndt R. R. 20142 Arnell J. C. 3321168 372171 Arno M. 5211698 Arnold D. R. 5191512 Arnold H. J. 5151194 Arnold K. 588128 Arnold N. 5151194 Arnone A. 1601167 384163 5561186 Arona R. 159179 Arondel V. 3571176 Aronoff S. C. 3311117 Arrebola M. L.5161252 Arreguy-San Miguel B. 5161292 Arriaga F. J. 676116 Arro M. 141135 43 Arrondale R. F. 96121 Arrowsmith D. A. 10180 Arruda A. C. 475193 Arruda M. S. 43/93 Arruda M. S. P. 731164 617118 Arrudo A. C. 617118 Arsenault G. P. 24211 74 175 I76 Arsequell G. 1831349 353 3571188 190 3581199 Arslanian M. J. 3571145 Arslanian R. L. 741266 2561107 Arteaga J. M. 1611221 Arya M. 4091319 Asaad A. M. 676131 Asada C. 142185 Asai A. 4291125 Asai I. 5171355 Asai M. 331152 450181 82 45 111 02 145 Asaka Y. 255173 Asakawa S. 9119 20 Asakawa T. 1621336 Asakawa Y. 20154 159168 69 99 1621291 335 345 348 230 255120 48 55 2571229 4281103 4751117 5221810 618169 75 650113 6771122 6791207 Asaki H. 255152 Asakura T.741276 Asami A. 40512 Asami M. 2971164 38511 77 Asano N. 6511112 Asao N. 51 81430 Asao T. 1611220 Asaoka M. 1611270 1621328 2991279 63611 I0 Asari F. 1811203 Asari T. 296167 68 463139 Asberom T. 651185 Ascenso J. 256182 Ascenso J. R. 677165 Aschauer H. 356155 Aschenbach H. 4081215 Asen P. A. 1891887 Asfaw N. 5151177 Ashizawa T. 427123 Asibal C. F. 659139 Asiedu D. 1831422 Asiedu D. K. 1831415 Aslanov K. A. 255128 40 Aso M. 5181482 Asoh K. 158111 Asoh T. 618141 Assaf M. W.,731148 Assaf S. 1851562 Assante G. 5561186 Asselineau C. P. 356189 Aster S. 3861225 Astles D. P. 474128 475154 Asturias J. A. 5551115 Asuami J. I. 406172 Asuda I. Y. 5221777 Asunka S. A. 677168 Atarashi T. 20155 Atchison K.7311 97 Ateya A. 659133 Ateya A.-M. 635177 Athayde M. L. 6791229 Atkinson J. G. 1801123 Atkinson R. 514173 Atsuya T. 407l171 Atta F. M. 514191 Attalla H. 71/18 Atta-ur-Rahman 82/42 50 256196 589161 74 Attenborough S. 981168 Attgalle A. B. 6361134 65011 7 18 Attucci S. 142163 64 84 Au K. G. 4521185 Aubt J. 635191 Aube J. 2571179 186 Aubert F. 1841483 484 Aubourg S. P. 1871730 733 Audran G. 5211702 Audran J.-C. 20112 Auger S. 384171 99 I00 August P. 4511133 136 August R. A, 218160 61 Augustine R.L. 5891115 1-48 Natural Product Reports 1997 Aulbekov S. A. 255140 Bailey N. A. 5181404 Baranovskii A. V. 3851196 Bass C. G. 2981240 Bassani V. L. 5151152 Aursand M.. 1871729 731 732 Bailey P.D. 589151 Baras A. 406153 Austin H. 1881807 Bailey T. R. 3841109 Barata L. E. S. 72165 131146 Basset J. M. 5161301 Ausubel F. M.. 241145 Baillargeon M. W. 1871794 796 659145 46 Basso E. A. 5191563 Authier L. 384191 1881826 827 832 Baratti J. 1881885 Basson D. S. I861680 Auzi A. A. 618168 Baillie L. C. 203122 Barba I. 5 181480 Bastiaans H. M. M. 2981186 Avalos J. 1441259 Baird M. S. 1831351 352 356198 Barbarulo M. V. 463169 Bastida J. 30311 8 9 20 428188 Avdiushko S. 141139 6031128 Bajpai P. 1881877 879 Barber A. D. 618159 Bastos J. K. 71111 Aversa M. C. 5201633 Bajpai P. K. 1881877 879 Barboni L. 401128 82120 2561151 Bastow K. F. 11131 Avery M. A. 1601140 Bakare O. 1831408 409 2571152 163 170 5211687 Basu A, 6361113 Ada C. 296123 1841429 1861701 704 Barbosa L.C. A. 741238 Batabyal A. 20146 Avilov D. V. 218179 Baker A. J. M. 96145 Barbosa-Filho J. M. 401103 71143 Batenhorst R. L. 4101379 Avron M. 463184 Baker B. J. 2581234 2981212 243 4081223 Bates R. B. 71145 Awad E. S. 3511145 2991283 3001380 41 7 Barcellona S. 3511105 Bates R. W. 141275 Awen B. Z. 5191531 30 1I41 8 463162 Barco A. 650140 Batista C. V. F. 588140 Awl R. A, 1851546 Baker C. H. 676111 Bardon A, 2561119 Batista O. 1621343 256193 Batista T. G. 5151216 Axelrod B. 1801144 1851557 Baker D. C. 475174 75 Bargar T. M. 40186 Barges V. 1611240 243 Batley M. 2571198 3001345 Axelsson B. S. 218190 91 Baker F. C. 1821264 Axten J. 428176 Baker J. A. 141150 602129 Barion J. 5221791 Batlzer B. 3311108 Barjavel M. J. 4081270 4091286 Batna A.1821268 1831390 391 392 Ayafor F. J. 256178 Baker J. T. 2991290 Ayala J. 1101104 Baker M. A. 635126 Barke R. A. 4091344 Batra M. S. 5201621 Ayanoglu E. 1841455 2911156 Baker M. E. 10170 77 82 95 Barkhash V. A. 1591109 514177 Batsuren D. 4151118 Aycard J. P. 5151158 3331220 5 161305 5 171383 5 191574 Battaglia C. 4101413 Battershill C. N. 1841451 452 Aydinlioglu A. 635170 659140 Baker R. 650132 39 5211711 712 357112 7 128 312194 Aydogdu S. 142156 602151 Baker R. W. 5201651 Barkman T. 5 151220 Aydogmus Z. 2911124 Bakkali E. H. 406179 Barlas J. 1831403 Baty J. D. 1851597 Ayet G. 401123 125 635167 Bakker H. J. 2431192 Barlow S. A, 241127 Bauer F. 721100 Ayorinde F. O. 1821261 Bakogeogou E. 4091364 Barnathan G. 1811176 179 180 Bauer I. 296159 60 Ayres D.C. 72192 Bakshi R. K. 3861225 196 197 Baum E. 296157 427114 Ayukawa A, 602155 Bakthavachalam V. 6511110 Barnea A. 97169 Baum G.. 427112 Azoulay. M. 3581247 Balacs T. 51319 Barnes C. L. 2571196 199 3001347 Baumann A, 1611259 1621309 Azuma M. 428141 Balakhane E. 4111452 Baronowsky E. 356153 5 171.328 Azzaro M. 1611212 Balakrishna K. 6181127 6791226 Barr G. A. 4091296 Baumann H. 39164 180191 Balakrishna L. 650150 Barr R. J. 303114 Baumann P. 406178 Balansard G. 1611271 5221792 Barr S. A. 20125 31 32 Baumberg S. 312183 6791234 Barraclough P. 2191113 Baumel P. 401104 635182 Balaschak M. S. 2971153 Barragan A, 1601194 161121 7 Baumert A, 312160 61 Balasubramanian S. 3851162 5 151167 Baumgarten S. 6181157 Baaliouamer A, 5 141137 Balazy M. 1871773 Barrero A.F. 731130 141261 262 Baur A. 96120 Baart J. 218120 2191118 Balcells L. 141135 159159 16011 94 21 7 1621349 Baur B. 96120 Baba J. 9132 33 34 35 Balchin M. L. 428147 300141I 5 151167 5 111312 Baur R. 971117 Baba N. 1611210 Baldenius K. U. 109161 Barrets A. J. 330127 Baxter H. C. 3581244 245 Baba T. 356190 5561181 Balderrama L. 61711 Barrett J. F. 589/69 70 Baxter R. L. 2191104 2561100 Babu J. M. 2911135 Baldessari A, 1891907 384157 Barrie S. E. 3851135 3581244 245 312194 Bach T. J. 14113 4 21 22 32 5 171380 Barrish J. C. 1831368 Baykousheva S. P. 1801146 5 13142 602121 22 Baldew A. U. 2191121 Barroso J. G. 5141101 5151195 Bayquen A. V. 651187 Bacher A, 602158 Baldwin I. T. 96147 97173 74 Barrot M. 1831353 1841466 Bazzocchi I. L. 6791209 210 Bacher M. 611114 Baldwin J.E. 218169 80 2191114 3571190 3581200 Beach D. H. 3571124 Bachmann H. 4281104 2431190 3321128 157 166 178 Barrow C. J. 618155 56 611179 Beak P. 401154 6361103. 104 105 Bachmann P. 371115 635176 179 181 188 189 193 196 Barrow K. D. 2561109 106 109 111 113 Bachovchin W. W. 2191119 3331209 211 212 223 224 228 Barrow R. A, 1811192 Beal A. M. 97166 Back K. 1431143 146 312174 75 77 78 Barrows L. R. 2991262 3011449 Beal M. H. 981179 Back T. G. 3851199 3861231 Bali Y. 202115 Barry J. F. 4291109 Beale A. S. 33016,7 5201583 Balk-Bindseil W. 296130 428159 Barstad H. 1881843 Beale J. M. 3561102. 311133 450124 Backhaus R. A. 30313 4 14 Ball R. G. 650139 Barszcz B. 1621301 25 26 4511110 151 156 157 Backvall J. E. 1821299 Ballas L. M. 4281101 Bartel P. L. 555147 5 5 5/47 55 Badalbaeva T.A. 255128 Ballio A, 3571105 Bartelt R. J. 3581195 196 Beale M. H. 241174. 241188 Badar Y. 589161 Baltanas M. A. 180189 Barth W. E. 3311105 2431198 2561114 Baden D. G. 296170 463140 Bambagiotti-Alberti M. 11114 15 Barthe P. 1431186 Beaman B. L. 1871783 Bader G.,6191202 85 Bartlett M. R. 39150 51 Bean M. F. 2981207 Badillo A. 142181 Bamberg D. v. 451/139 Bartlett S. E. 4091358 Bearder J. R. 203122 241161 74 Badoc A, 1431131. 132 133 513146 Bamford M. J. 10816 Bartley G. E. 142182 83 24211 72 173 178 179 183 193 47 48 Ban N. 1611274 4631101 Bartley J. 1601168 199 Badre A. 3011447 456 Banaigs B. 25516 8 297194 101 Bartley J. P. 514198 Beare-Kogers J. L. 1861687 Bae M. 40711 71 102 3011447 3011456 Bartnik E. 10815 Baek E. 2991312 Banandha K.K. 3841110 Barton D. H. R. 39113 371122 Beastall G. H. 463132 Baenziger J. E. 1871786 Banavali N. 450135 5 191508 Beaucourt J. P. 1841483 484 Baer H. H. 109130 Bandoh H. 635149 51 Barton G. J. 2431190 3321189 Beaudry B. 406146. 4081259 Baertschi S. W. 1851569 Banerjee A. 6791213 372174 Beaulieu P. L. 218186 Baetas A. C. S. 2019 475193 Banerjee A. K. 1611238 Bartoszeck M. 303112 13 Beaupcre D. 635133 Bag B. G. 3851165 Banerjee S. 38511 76 Bartroli J. 218168 Beavers L. S. 3851189 Bagby M. O. 1821304 305 1811742 Banerji A, 255159 Bartsch W. 1811224 Beccalli E. M. 42711.5 1891892 8Y3 894 895 899 Bangert F. 1831375 Baruah R. N. 5141122 129 5161237 Becerra B. 141143 Baggaley K. H. 331170 3321162 Bankova W. 1101102 Barzu O. 217116 Becerra J. 1611252 163 169 170 173.178 179 193 Bankovic V. 5161225 Basabe P. 159158 60 255150 51 Becicka B. T. 5181459 196 3331197 198 200 209 211 Banks M. R. 5201631 Basak A. 3321158 177 3331216 Beck D. 5551111 212 215 Banner W. K. 5221812 Base J. 1851610 Beck J. 3511151 5561156 157 Baggiolini E. G. 1831368 Banon J. 5181480 Baser K. H. C. 5141113 138 Beck K.-F. 3511151. 3581212 213 Bagryanskaya I. Y. 1621299 Bansal V. 4151114 5151144 171 188 191 193 198 Beck W. 5891108 2511200 199 200 201 219 222 5161224 Becker A. M. 4511142 Bagshawe K. D.. 109133 Banstola K. P. 671175 Bahuguna R. P. 6781152 Banthorpe D. V. 82/75 514176 227 231 232 248 249 251 253 Becker B. 5161230 Bahuguna S. 514170 602132 61 6031115 119,120 121. 5 111353 Becker H. 141273 1431177 1601175 Basher R.4091339 1611246 1621346 255172 2581231 Bai D. 650143 44 122 141 142 Basiladze M. 21 8123 5891121 Bai Y. 20141. 202110 14 16 203121 Bantignies B. 142157 602153 5 14/59 659122 Banville D. L. 109139 Basile D. V. 1431170 Beckert R. 384183 84 Basilio A. 256177 Beckham C. J. 660159 Baig M. A, 82175 Bao K. 5551116 Baikenova G. G. 636194 Bao P. Q. 5151187 Baskaran S. 12160 Beckman A. L. 4081263 Bailey C. R. 3321164 3331198 Barabee E. B. 3331210 Baskunov B. P. 20117 Beckman J. K. 1841514 Bailey D. T.. 741266 2561107 Baraldi P. G. 4291124 Basnet P. 4071147 Bedorf N. 617120 Index of authors cited Beebe J. M. 1801104 1851603 604 Beppu T. 553116 17 554120 21 Beecher C. W. W. 405114 5 5 5/82 Beeve J. L. 96113 Beran M. 41 11460 Begum S. 203134 5221785 Berchthold G.A. 4521185 6171124 6781125 6791224 227 Berdeaux O. 1841492 Beholz L. G. 651190 Berecibar A. 39145 Behrendt L. 218157 Bereman R. D. 401142 Beifuss U. 5 17/31 7 Beremand P. D. 3571157 Beiner D. 383124 Berenbaum M. R. 91172 Beis S. H. 5151222 Berendsohn W. 256191 Beiswenger C. 4011183 Berentsveig V. V. 5161294 Beke G. 4071163 Berenyi S. 4081238 257 Belair S. 2571155 Bergamasco B. 4081204 Belcour B. 5211692 Bergasa N. V. 4101384 Belem-Pinheiro M.-L. 58815 Berge R. K. 1831415 418 419 420 Belikov V. M. 218126 421 422 Belin J.-M. 3571152 5211691 Berger A, 1811165 Belknap J. K. 4081276 Berger D. 463147 Bell A. A. 1431163 1601123 Berger H. J. F. F. 218178 1611236 Berger M. 1881846 Bell K. 4081239 Berger R. 1891898 Bell M.R. 384162 Berger R. G. 1601173 1811165 Bell R. N. 1421112 5 161280 Bell S. J. 428142 Berger S. 383113 Bellakhdar J. 514187 Bergheim S. 1851579 Bellamy F. 1821292 1831362 363 Bergler H. 356155 Belle D. D. 5891100 101 Bergman J. P. 3861225 Belleau F. 5 1511 72 Bergman R. G. 109154 Belles X. 141119 20 27 Bergmann J. 4101415 Bellevue F. H. 3851169 Bergmann R. G. 5561131 Bellevue 111 F. H. 3021495 Bergon M. 4081256 Bellina F. 159177 78 Bergon P. 4511115 116 117 Bellis J. M. 3321161 Bergonon S. 30311 Bellomaria B. 401128 5 141104 Bergquist K. E. 256178 5 1 511 94 Bergquist P. R. 2991298 Bellosta V. 1611263 Bergseth S. 1831416 417 418 Bellur N. S. 5211666 Bergstrom G. 971118 Belmont M. R. 406145 Bergstrom J. D. 55611 76 Belmont S. E.40179 Bergstrom L. G. 971133 138 Belokon Y. N. 218179 Bergter L. 5 181411 Belova G. A. 20149 Beriashvili T. V. 5161276 Belton P. S. 1861695 Berkett N. 3011428 Beltran F. J. 5191505 506 507 Bermejo A. 406179 Belyaeva M. G. 5181448 Bermejo J. 159152 1601180 588111 Bemis D. L. 1811169 296179 617121 Benage B. 589163 Bermejo P. 1621317 475184 Benaim J.-Y. 25516 Bermejo R. 40511 Ben-Amotz A. 463184 Bermejo-Gonzalez F. 39112 Benaokm J.-Y. 2911101 Bernan V. S. 296128 4641113 Benayahu Y. 2571222 2991299 313 Bernard E. M. 38511 70 3001377 3011452 650110 Bernard-Dagan C. 6031124 6791241 Bernardi A. 415187 5191548 Bendall J. G. 255144 256181 Bernardi L. 3851174 Benedetti-Doctorovich V. 4071191 Bernardi R. 384163 Benedict C. R. 1431163 1601123 Bernardinelli G.2971120 Benetti S. 650140 Bernart M. W. 1811235 1821243 Benevelli F. 2581237 2971113 3571133 Beney C. 3841111 Bernasconi R. 401127 Bengtsson A. 40517 Bernays E. A. 9616 Bengtsson J. 40517 Bernotas R. C. 39160 Bengtsson J. P. 40517 Bernstein M. A. 5221811 Benharref A. 1601142 Berque I. 6361101 Benhye S. 4081254 255 Berranger T. 5201625 Benjelloun N. R.,651163 Berree F. 5201623 Benn M. H. 202114 16 659122 24 Berrio L. F. 63517 Bennani Y. L. 1821321 Berry D. L. 660174 Bennasar M.-L. 588124 26 43 44 Berry P. D. 3311101 103 589/48 49 50 Berstein E. R. 21114 Benner J. P. 41 11457 Berstein P. A. 1841503 Benner S. A. J. 3581249 Bertazzoli C. 109125 Bennett G. J. 141267 Bertelli A. 4091324 341 Bennett J. W. 5561162 Bertoli A. 475186 Bennett M.H. 981181 182 Beruabe M. 97197 Bennua-Skalmowski B. 384161 Besanzon G. S. 451196 Benosman A. 677166 Bespalov A. Yu. 4091290 Benotti P. N. 1441250 Besra G. S. 1821283 356185 97 Bensch W. 5181454 Bessiere J. M. 255117 514186 95 Bensch W. R. 3851189 5151150 152 205 212 5161261 Benson R. J. 241184 Besson M. 5181397 Bensoussan M. 3511152 Bessonova I. A. 61716 618132 Bentivoglio A. 4081208 660162 Bentley K. W. 4061108 Bessoule J. J. 1801147 3571171 Bentley M. D. 677177 78 Best E. A. 356164 Bentley P. H. 3311101 102 103 Besterman J. M. 255122 5901137 Bento E. de S. 1611229 Bestmann H. J. 3581191 5151146 Bento J. M. S. 96/32 Bestmann H. J. 96127 28 1611283 Benveniste P. 141134 Bestwick C. S. 981181 Benz S. K. 110199 Bestwick L.981182 Beppu T. 3581238 Betancor C. 384180 1-50 Natural Product Reports 1997 Bethel D. 5201649 Betts T. J. 513128 Betzer J.-F.,6511116 Beutelmann P. 1811186 3571155 Beutler J. A. 159186 2971131 142 6791206 Bevalot F. 2015 414126 Beveridge D. L. 109163 Bevitt D. J. 356176 3581221 555170 Bewley C. A, 4641111 Beyer P. 602134 65 60311 14 Beynon P. 450185 Beyou A, 141130 Bezuglov V. V. 1811160 Bhadbhade M. 2971135 Bhakuni D. S. 82/38 58 3571122 55611 44 Bhakuni R. S. 2571182 Bhalay G. 618147 Bhalerao U. T. 1821322 1831340 Bhamidipati R. S. 1611241 297193 5 161297 5 181464 Bhandari K. 331164 Bhandaru S. 3851212 213 Bharathi S. N. 63415 Bhargava A. N. 4081270 Bhargava H. N. 4091286 305 4 101406 Bhat H.K. 1851575 Bhat K. L. 8115 82163 Bhat P. V. 1441243 247 Bhatnagar D. 5561161 162 166 167 169 Bhattacharjee J. 47415 Bhattacharya A. K. 5151159 Bhattacharya P. K. 618166 Bhattacharya S. K. 4091303 Bhattacharyya D. K. 1881808 Bhattacharyya M. K. 141136 Bhattacharyya P. 42115 Bhattacharyya S. 1881808 Bhattaracharya B. J. 406196 Bhattarai K. M. 384170 Bhonsie J. B. 1601129 Bhotmange M. G. 1881825 Bhounsule N. J. 1611267 Bhushan V. 5891124 125 Bhutani K. K. 6191228 Bi J. L. 97181 Biala R. G. 589155 Biallab A. 1 101107 Bian D. 4081274 Bian S. 41 11461 Bian T. Y. 4091320 Bianchini G. M. 602127 Bianchini J. P. 1611212 Bianco A. 5211713 5221787 Bibb M. J. 554129 30 31 38 Bick I. R. C. 82153 6511102 Bickelhaupt F.5211665 Bicknell W. 108117 Bidlak J. M. 4101402 Bidya Sagar M. 383130 Biediger R. J. 5201598 Bieger D. 4091329 Bienestock J. 41 01377 Bienewald F. 5191530 Bieraugel H. 428178 Bierman U. 1831377 378 Biermann J. 82137 44 48 56 Biermann U. 1831374. 379 380 381 382 Bierner M. W. 1621311 Biesemans M. 383111 Bigelow G. E. 4101429 431 435 Bignami G. 1431200 1441254 Bignell C. M. 5161262 Bijpost E. A. 5211665 Bilfinger M. 91168 Bilfinger T. V. 4091314 Bilia A. R. 731126 4081218 475186 5211686 5221774 Billard C. 463176 Billen J. 96/26 Biller A, 96110 Billimoria A. D. 618151 Billings E. 3321141 Bills G. F. 15817 1591101 Binderup E. 3311108 Bindseil K. U. 555187 93 Biondi E. 5141104 Birch A.555l117 Birch R. H. F. 4101385 Bird A. E. 3321161 Bird M. 10816 Birdi K. S. 180164 Birge C. H. 356149 Birnbaum J. 330143 46 Bis S. J. 6511114 Bisagni E. 20158 618179 80 Bisch D. 372191 Bishop J. K. B. 1851583 Bishop M. J. 4641118 Bishop R. 5211674 Bisht K. S. 721121 125 144 232 233 234 Bisseret P. 602147 Bissoue A. N. 474126 Bittiger H. 406178 Bittman R. 1821303 3851190 Bjelakovic M. 384173 Bjoerkman S. 4091304 Bjoerneboe A. 4101400 Bjorkheim I. 3851186 Bjorklund J. A. 371133 Black K. D. 1871708 Blackburn J. M. 312175 Blackman A. J. 296119 56 2971128 3011434 Blackman A. J. 96149 Blackmeer A, 971108 Blackwell A. 97/92 Blair I. A. 1841482 Blake A. J. 2561100 5201631 Blake G.4071183 Blake K. 721113 Blanc V. M. 141151 602198 Blanche F. 372191 Blanco G. 555149 50 Blanco J. L. 55611 70 Blanco J. M. 5181407 Blaney W. M. 97160 159159 255151 300141 I Blank S. 218156 Blankespoor C. L. 650117 Blanpin O. 82171 Blanz P. 450154 Blase F. R. 428182 Blaser D. 218183 Blasko G. 650135 46 Blaskovich M. A, 218187 Blaszczyk K. 384182 Blay G. 1611240 243 244 Blazevic N. 5161246 255 Blechert S. 1431181 159166 311127 Blee E. 1851556 565 566 1891900 Blee E. 3571181 Bleecker A. B. 2421119 Blein J.-P. 5561190 Bliard C. 109151 3011457 428197 67617 Blizzard T. A, 109149 52 88 Bloch K. 356153 61 77 Bloch R. 39166 1821319 5201645 Block D. 1841463 Block K. 3321194 Blokhin A. 5221782 Blokhin A.V. 371119 651176 Blomberg L. G. 1861664 665 666 602168 Blomquist C. 3581197 Blomquist G. J. 96135 142194 3 5111 85 186 35811 97 Blomstrom A. C. 1881823 Bloor S. J. 2991263 41 11457 Blosyk E. 971103 1601165 1621323 Blount J. F. 3001355 331181 Blows W. M. 5561174 Blum M. S. 96/21 Blume A. 450158 Blunt J. W. 97/96 372194 Boatman P. D. 5201598 Boaventura M. A. D. 2561122 129 Bobbitt J. M. 411157 Bobik E. 1861661 Bobzin S. C. 2981225 Boche G. 6361114 Bochet C. G. 651179 Bockholt H. 555159 Bork W. R. 158114 474117 Brahmachari G. 6771123 Brown A. G. 33012 8 9 10 37 38 Bocskei Z. 383133 Borkosky S. 2561119 Brajtburg J. 109196 47 331187 88 96 Boczon W. 401132 133 134 135 Bornscheuer U. T. 1881839 844 Brambilla U.1601167 Brown A. M. 3331203 149 635186 Boronat A. 141132 35 43 44 Bramlage W. J. 1841517 Brown A. R. 5201631 Bodd E. 4101400 Borovkov V. V. 384145 Bramley P. M. 6031139 Brown D. 331172 Boddy I. K. 651166 Borovok H. 2431191 Branch S. A. 6031142 Brown D. M. 6191205 Bode J. W. 721111 Borowiak T. 401139 140 635184 Brandi A. 39115 17 635111 12 13. Brown D. S. 5551122 Boden C. D. J. 3011444 85 86 14 Brown E. 721102 141257 258 Bodnaryk R. P. 97175 Borowski E. 1101100 I01 Brandon S. 96149 Brown E. G.,6511121 Bodo B. 650120 21 6181126 Borquez J. 255149 Brandt V. 58812 Brown G. D. 14311 74 Body D. R. 180187 Borschberg H.-J. 588129 Branfman A. R. 450180 Brown H. C. 5191539 540 541 Boe G. 1431211 Borsodi A. 4081240 Brantley S. E. 1841444 2971155 542 543 545 Boeck L.D. 33011 331183 Borup-Grochtmann I. 4521188 Braquet P. 11125,26 Brown H. E. 4091346 Boeglin W. E. 1851569 5561150 Brash A. R. 1851569 Brown J. T. 602119 Boehm J. C. 3841106 107 108 Bosch J. 428144 588114 24 26 43 Bratovanov S. 5201581 Brown Jr. K. S. 3911 Boerman M. H. E. M. 1441239 44 589148 49 50 58 59 60 Bratz M. 2911126 Brown K. R. 109144 Boettner F. E. 30314 Boschung A. F. 5191495 Brauchli R. 1611275 5211693 Brown K. S. 659145 46 660153 Boeykens M. 2971114 475189 95 Bose G. 24 1I50 Braun A. R. 4071200 Brown M. S. 450149 50 659132 Boge T. C. 2571192 Bosser A. 5211691 Braun R. 5181478 Brown P. R. 179134 1801104 107 Boger D. 109177 79 Bostock R. M. 141139 6031127 128 Bravo F. H. 5221752 1851590 603 604 Boger D. L. 618137 38 4081222 Bothast R. J.3321155 Bravo R. V. F. 81115 Brown R. F. C. 4511142 4291124 126 Bothma C. 981158 Bray D. H. 4061115 Brown R. P. 3321142 Bogucki D. E. 731196 Boto A, 384180 Braz-Filho H. R. 677162 Browne E. N. C. 5191520 521 Bohlendorf B. 617120 Botsoglou N. A. 1851519 Braz-Filho R. 589197 Browse J. 1811148 Bohlke M. 405135 Bottalico A. 981153 154 155 Breau M. L. 2991295 Bruck F. M. 3571162 Bohlmann J. 20128 372162 Bottger D. 1101102 107 Breazeale S. A. 4511117 Bruckner B. 1811217 Bohm G. A, 450120 48 Bouchara J. P. 514194 Brechany E. Y.,1811167 215 Brueggemeier R. W. 3841121 122 Bohm W. 602169 Boucher J. F. 3918 1861626 636 1871763 764 Bruenger E. 602177 6031116 Bohnert J. C. 589165 Boucher R. R. 4081263 Breckenridge G. H. McG. 186/627 Brufani M. 450175 84 Bohsako A. 5891114 Boudi A.3851143 Breeden L. 4091315 Brugger R. 3581237 Boiko S. S. 4091342 Bouille G. 109194 Breen A. L. 2981207 Bruice T. C. 358/250 Boitiaux J. P. 5161301 Bouillet C. T. 5191496 Breitenbucher J. G. 3912 Bruin J. 97188 Boito S. G. 4071164 Boukouvalas J. 159182 Breitmaier E. 1601156 1611284 Bruix M. 616116 Bok S.-H.,2991312 Boulanger A. 3011447 456 255132 405115 4011148 650115 Brukwicki T. 401137 635187 Bokanga M. 312166 Boulanger W. A. 475172 Bremer J. 1831417 418 420 Brumby T. 5221814 Bokichev V. H. 4081227 Boullais C. 1841484 2571193 Bremner J. M. 4011202 Brummel M. 1851592 3571167 Bol D. J. 514196 Boulton D. A. 141118 Brennan J. P. 589188 Brunel J. M. 5181408 Bol W. 5211718 Boumzebra M. 51915.53 Brennan T. M. 39154 55 56 57 Bruner S. D. 159165 2991254 Boland W.1421127 128 14311 79 Bourauel T. 659136 Brenneisen R. 1611280 Brunet E. 5201621 180 181 182 296184 85 297186 Bourdele J. L. 513115 Brenner D. G. 3311120 3321139 Bruneton J. 677166 Bourdy G. 2981223 2991266 Brenner M. L. 2421137 159 Brungs P. H. 2981185 Bolessa E. A. 3851161 Bourgeois M-J. 5191528 Breuer J. 1621309 5171328 5181484 Bruni A. 474112 Bolikal D. 2571191 Bourguet-Kondracki M. L. 427126 Breuer M. 4511116. 139 Brunke E. J. 159188 Boll P. M. 721121 125 144 232 Boury-Esnault N. 1811176 Brian P. 555149 50 Brunner H. 5 181399 233 234 Bourzat J.-D. 5901134 Brideau C. 71146 Bruno I. 2981223 2991266 Bollag D. M. 731183 Bousquet L. 5191533 Bridges A. M. 3511109 110 Bruno M. 1601195 255164 65 67 Bologa M. 217116 Boustie J. 617190 Bridges C. G.39154 55 56 57 58 70 463169 Bolognesi M. 4081247 Boutin J.-P. 660157 59 Brunow G. 72158 59 Boltanski A. 3321156 174 Bouvard M. P. 4101411 Briggs S. L. 4101401 Bruns W. 1601157 Bolton G. C.. 331198 Bouvier M. 41 11448 Bright G. M. 109186 Brussee J. 60119 Bolton R. 5201626 Boven E. 109134 Brillet-Fernandez C. 39166 Bruton G. 331189 Bombarda I. 5151158 Bovens M. 5181443 Brindle P. A. 6031125 Bryan P. 3011479 481 Bombardelli E. 2571163 185 371136 Bovomsombat P. 5201601 Brindley D. N. 356177 Bryan P. J. 3001417 3011418 463162 Bonaccorsi P. 5201633 Bowden B. F. 3001355 3011465 Bringer-Meyer S. 602128 Bryan R. F. 450179 Bonasera T. A. 3841126 3851140 Bowen D. H. 240111 241167 Bringhen A. O. 33211 78 179 Bryans J. S. 33211 78 179 3331211 Bonavida B. 71125 26 Bowen K.M. 39152 53 Bringmann G. 1841513 405129 Bryant C. 1431142 Bond T. J. 40180 Bowers M. D. 911119 428195 Bryant R. 6181198 Bondarenko-Gheorghiu L. 384181 Bowers M. M. 82166 Brito I. 981178 186 255149 Bryson T. A. 5201589 Bondesson U. 217110 Bowers R. J. 660159 Brito J. A. O. 617118 Buang H. 4011139 Bondoux D. 4101411 Bowers W. S. 97196 5161259 Brito-Palma F. M. S. 255169 Buchanan M. S. 4281103 Bonetti S. 659138 Bowman R. M. 20126 Briwn P. I. 109132 Buchardt O. 71124 Bongianni F. 4101380 Box S. J. 330140 42 Brl A. 4511169 Buchbauer G. 514172 85 118 Bongiorni L. 46211 Boy K. G. 158125 Brl M. 4511170 5 1511 64 21 4 Boniforti L. 3571105 Boyd D. R. 20125 32 Brlik J. 589187 Buchs A. 1811228 Bonin M. 588137 Boyd K. G. 158127 991267 3001414 Broadbear J. 4101416 Buchwald S.L. 40178 4641117 Bonjoch J. 589159 60 99 Boyd M. H. 159197 Broadbent T. A. 8118 Bucio M. A. 428171 Bonnard I. 3011447 Boyd M. R. 159186 203127 28 29 Brock C. P. 383131 Buckingham J. 44913 Bonner D. P. 331153 2971130 131 142 153 2981191 Brock M. L. 109181 Buckl P. R. 45211 79 Boom T. V. 355112 192 193 194 195 218 2991328 Brock T. D. 109181 35519 450153 Buckle D. R. 1831361 Boon R. J. 33016 7 3011440 483 484 485 30313 55319 Bucknall G. A. 602161 6031121 Booser D. J. 108113 475168. 70 71 61 714 Brockelmann M. 6791244 Buckner J. S. 3581231 Boot A. J. 1861693 6791206 Brocksom T. J. 5181447 Budesinsky M. 91191 158120 Booth Jr. J. R. 3571177 Boyd R. S. 96142 43 44 Brocksom U. 5 181447 1611205 1621323 4071167 Boother P. 41 11457 Boyer F.-D. 6511115 Brodschelm W.371127 Buesa C. 141119 20 27 Boppre M. 96110 660152 Boyer S. H. 109167 Brodsky M. 4101405 Buevich A. V. 159167 Boralle N. 475187 Boykow G. C. 2991249 Broekaert W. F. 981167 168 169 Bugbee W. M. 1811205 Borch-Jensen C. 1861652 Boynton J. A. 384151 I12 Brogden R. N. 3311107 Bugge A. 4081235 Borchorakova H. 4071151 167 Boys C. W. G. 3581245 Broka C. A. 462115 650130 Buhler M. 180191 Bordell M. M. 3841116 Boys M. L. 6361106 Brooks G. 331189 90 99 100 101 Buhmann M. 5211672 Borden J. H. 96/33 Bozza P. T. 71143 102 103 Buist P. H. 1831410 411 412 413 Borden N. 4091308 Br S. 5221814 Brooks P. R. 5211674 414 1851573 1891905 Borders D. B. 109156 555158 Bracher F. 2981203 650125 58 Brooks S. C. 3841105 Buitelaar J. 4101408 Bordoloi D. N. 5141139 Brachet-Cota A.L. 3851141 Brookshire K. W. 109169 Buketova G. K. 1621299 Borer B. C. 428178 Bradbrook I. D. 3311109 Broom N. J. P. 3311122 Bulboaca G. H. 358/246 Borges J. 1601204 Brader G. 617114 Brophy J. J. 514183 92 96 106 Bulej P. 4081241 253 Borgeson B. 4631106 Bradesi P. 5171371 107 121 133 5151142 182 197 Bull H. G. 3861225 Borg-Karlson A. K. 971128 132 Brady P. A, 5891110 Broquet C. 71125 Bull S. D. 5111341 5181450 135 137 513130 36 5151207 Braekman J. C. 296154 2981208 Broschard R. W. 450183 Bullard C. 5211660 Borillas W. 405136 462116 61 8/26 6361132 650155 Brossner D. 588130 Bullivant L. 5181397 Index of authors cited 1-51 Bullock M. W. 5551110 Caceres-Cortes J. 109122 Bullock W. H. 2971126 Cachet T. 109192 Bu’Lock J. D. 450156 60 63 Cadavid M.4071190 Bulow N. 1611218 Cadogan J. I. G.,5201631 Bulsing J. M. 555191 Caelles C. 141135 Bumbasirevic B. 41 11454 Caffrey P. 450120 55315 68 70 74 Bumol T. F. 3851189 Cafieri I:. 2971139 2981228 246 Bumulka M. 1601181 2991293 Bunick G. J. 3581216 Cahiez G. 5181457 Bunning T. J. 383134 Cahoon E. B. 3571174 175 180 Bunton C. A, 602197 Cai D. 406182 Buono G. 1881885 5181408 Cai H. 4291124 676120 6791205 Burandt C. L. 71111 Cai K. 4081258 Burbage P. W. 5151176 Cai M. S. 203132 Burbano C. 401123 125 131 Cai P. 1601187 635167 Cai Y. 4281102 6781164 165 Burbott A. J. 6031118 Cai Z. 5191510 Burch M. T. 3001362 Cain A. N. I601202 Burczyk J. 6781157 Caira M. R. 589154 Burden B. J. 97178 Cairns N. 414128 475154 Burger U. 5221800 Calais I.255124 Burgess E. M. 4071191 Caldera S. 71145 Burgess J. P. 4081243 Calderari G. 218154 Burgess J. R. 1811168 Caldwell S. E. 1851534 Burgess K. 6361126 Calera M. R. 1611213 Burgess L. E. 618167 Calhoun D. H. 4521181 Burgoyne D. L. 2981196 371118 Calk I. 5211714 5221750 751 754 Burkard M. 428136 803 Burke B. A. 1811208 Callahan P. 96147 Burmester A. 141128 Callinan A. J. 5181402 Burnett R. J. 141133 Calvey E. M. 1801111 Burns J. J. 11145 Calvo R. 401125 131 406144 Burres N. S. 5561171 Calzada F. 1611251 Burrier R. E. 159148 2991249 Camara B. 142181 602188. 89 Burrows C. J. 3851167 Camatte S. 406153 Burton G. 3851141 150 Cambie R. C. 255144 256181 112 Bury S. M. 3581245 298 Busby R. C. 3321186 372172 Cambon A. I611212 Busby R.W. 3321186 3331218 229 Cameron D.W. 9161 372169 72 Cammack J. H. 2991331 Buschinger A 650119 Cammue B. P. A, 981167 169 Buschmann H. 1601182 1621314 Campaigni E. E. 677191 Bush E. J. 731194 Campana C. F. 1601136 Bush K. 330122 23 24 331153 118 Campbell A. C. 38319 Busmann D. 5161280 Campbell D. R. 71139 Buss A. D. 372183 85 Campbell J. R. 1841486 Buss V. 141252 Campbell J. R. R. 4521182 Bussiere J. L. 4091312 Campbell W. E. 30318 Butelman E. R. 4091348 Campi E. M. 618165 Butkiewicz E. A, 141118 Campoli-Richards D. M. 3311107 Butler A. 1811168 296133 3571121 Camponovo F. F. 1621357 5561143 Camporesi E. M. 4101379 Butler B. D. 1821261 Campos K. R. 6361115 Butler J. H. 463168 Campos M. 4071190 474114 Butler L. G. 97163 64 981149 152 Campos N.141135 44 Butler M. 2191119 Butler M. J. 3321164 554131 Camps F. 1831349 350 353 Butler M. S. 2981216 240 1841458 459 466 3511187 188 Butler P. I. 1831348 189 190 3581198 199 200 Butsugan Y. 5161303 5171329 Canary J. W. 3021494 3851198 Butterfield D. A. 4101390 Cane D. E. 14118 142197 108 Butterworth D. 33012 39 143l141 142 147 148 149 150 Butterworth P. H. W. 356161 151 152 159 160 161 450173 Buttery R. G. 96137 5 1612 72 5 5 316 5 54/24 5 55173 Bycheck I. A. 1811188 189 5561202 Bycroft B. W. 1431153 154 Caniato R. 47414 3 3211 4 7 I51 Canigueral S. 514187 5161229 Bye R. 1611213 Cannarsa G. 741274 Byistro V. K. 635192 Cannell R. J. P. 5561172 173 Byrdwell W. C. 1871780 Canonne P. 158130 Byrne K. 450144 5551102 55611 75 Canteenwala T.A, 5181438 Byrne L. T. 4081233 Canto P. 401126 Byun H. S. 1821303 Cantoral J. M. 1601155 Cantoreggi S. 218157 Cao A. 4061118 C Cao D. 203139 Cao G. 5191524 Caamano O. 5 181407 Cao Y. 4081252 Caballero G. M. 384158 Cao Y. P. 406177 Caballero J. L. 554146 Cao Z. 5201627 5901135 Cabella G. 5201628 Capasso. R. 981153 154 155 Cabello F. 475183 Capiello A, 474111 Cabral J. A, 12/81 Capon R. J. 96129 15814 1611232 Cabras M. A. 5191551 1811192 25519 296120 2971129 Cabrera A, 415187 2981215 216 224 2991269 Cabrera G. M. 676142 43 29912 70 282 300 30 1I466 Cabrera R. 1601153 Capozzi G. 5 191534 Cabuslay R. 428190 Cappelletti E. M. 47414 Cacciari B. 4291124 Capperucchi A, 5191534 1-52 Natural Product Reports 1997 Cappon J. J. 218/20 22 2 1911I I 118 Capron M.A. 650153 Capson T. L. 4641113 Carabedian C. 296131 Caram J. A, 5171380 Carballeira N. M. 1811153 162 166 175 177 195 198,199 234 1821247 248 250 251 1841449 450 2971157 2991326 Carboni J. 2571184 Carda M. 5161270 Carde J.-P. 1431131 132 133 5 1 3/46 47 48 Cardellicchio C. 5191527 Cardellina 11 J. H. 159186 97 257122 7 296150 552971130 131 142 153 2991328 3001358 3011435 440 61714 6361130 6791206 Cardellina J. H. 475168 70 71 Cardena W. Q. G. 9811 78 Cardenas J. 255145 256194 105 Cardenas J. 6771121 Cardona F. 635114 Cardona G. 981188 Cardona L. 1611243 Cardono G. 981186 Caretta D. 4081208 Caretti D. 5891113 Carey D. B. 401110 Carey E. M. 3581226 Carey J. S.1601164 Carlini C. 5891113 Carlson D. 5201595 Carlson H. A. 383137 Carlson K. D. 1821265 Carlson K. E. 384192 93 Carlson P. H. J. 513119 Carlson T. J. 35711 77 Carmack A, 677191 Carman R. M. 255138 5171341 342 343 393 5 181450 Carmeli S. 9811 98 199 Carneiro da Cunha M. T. M. 401103 Carney J. R. 4511158 Carniti G. 428191 Carnuccio R. 2981228 Caron C. 20112 26 2571154 155 Carotenuto A,. 2991307 Carp F. 1421110 Carpenter G. W. 4091315 317 Carpita A. 159177 78 Carpy A. 71122 255143 Carr D. J. J. 4091315 317 Carr G. 5191525 Carrachas P. 3321192 Carre J. B. 3011476 Carrel J. E. 660148 Carretero J. C. 635132 Carrick F. N. 5171341 Carroll A. C. 731145 Carroll A. R. 12171 220 221 3011451 465 Carroll F.I. 303123 4081243 650141 Carroll M. 450132 Carroll M. E. 4101437 Carroll P. 82166 Carroll P. J. 5201638 Carroll T. R. 2981221 Carson M. 4521181 Carson W. G. 911120 Carss S. A, 383112 Cartayrade A, 602154 Carte B. 2981207 Carter C. A. G. 67618 677169 Cartwright S. J. 3311112 3321135 Carugo O. 2581237 Carvalho E. S. 636196 659110 Carver J. P. 635126 Cary J. W. 5561162 166 Casabuono A. S. 731158 Casadevall E. 1811206 Casals N. 141120 Casanova J. 5171371 Casapullo A. 2991315 Casas J. 676113 Casati R. 3561102 450124. 25 Casazza A. M. 109124 25 2571184 Casiraghi G. 39110 63413 Caspar H. 255169 Casper C. H. 650155 Cass Q. B. 741238 Cassady J. M. 1811182 6031103 65012 Cassagne C. 1801147 3571171 Cassano A.E. 180189 Cassar L. 20119 Cassels R. 3321166 173 178 179 3 33/21 1 Cassetta E. 4081208 Cassidy P. J. 330145 46 Castaiieda-Acosta J. I601202 Castaiiera P. 1601153 Castafio A. M. 39172 Castaldi M. 4101413 Castanas E. 4091364 Castedo L. 406198 100 102 103 4071159 4081211 Castellaro S. J. 241176 Castelluccio F. 3001413 Castillo L. V. 1611271 Castillo M. 5 171346 6791243 Castro M. A. 7117 21 22 23 88 188 291 255147 Castro-Faria-Neto H. C. 71143 Casuscelli F. 65917 Catalan C. A. N. 15811 1601170 184 1621306 2561119 Catalano S. 5221774 Catelan C. A. N. 731171 Catena J. 589199 Cates R. G. 589180 6771109 67811 96 Catherall E. 331164 Catino J. J. 109169 Cativiela C. 5 181416 427 5201635 Catsoulacos P.3861242 Cattaneo-Vietti R. 3001413 Cauduro A. D. 5151152 Cava M. P. 2981213 618151 Cave A. 405130 4071187 Cavalheiro A. J. 731136 265 Cavaliero C. M. F. 474114 5151154 Cavazza M. 4101444 Cave A. 731168 2971102 5161257 Cavell B. D. 241162 Cavender P. L. 241139 Caveney S. 2017 Cavicchioli M. 384163 Cavinato A. G. 1861692 Caviness G. O. 1851527 Ceccarelli N. 241169 Cecchini C. 5211686 Celerier J. P. 39168 635157 Celimene C. 39167 635153 54 Celmer W. D. 5561202 Cenini S. 20119 618130 Centeno M. L. 158133 Centurion 0.M. T. 384152 Cepoi L. 463185 Cerda-Garcia-Rojas C. M. 1601143 144 145 170 1621306 2971141 Cerda-Olmedo E. 1441259 Cernaj P. 513139 Cerny I. 3851134 149 Cerny R. L. 2981192.193 194 195 Cerreta F. 5201596 Cesarotti E. 1861643 Ch Man Y. B. 1881815 Ch R. 474116 Cha J. S. 5191546 547 Cha K.-H. 5901138 139 Cha 0.J. 5181482 Chabala J. C. 1831367 Chabinya M. L. 383134 Chackalamannil S. 159155 2991250 65 1/85 Chadha R. 463148 Chae Y.-A. 1421103 104 5171365 Chaffey M. B. 241161 Chagonda L. 5161230 Chagwedera T. E. 4071178 Chai H. 20115 407l178 Chai H. B. 255122 2561125 Chai W. 356188 Chai X. 1441239 240 Chain E.. 330112 Charon J. 1431135 Chen R. Y. 159171 5201612 Chinh T. D. 514188 89 90 116 Chairul 6791207 Charrouf Z. 6781158 Chen R.-X. 731132 117 Chakrabarti D. 635190 Charulpong P. 97/90 203145 Chen S. 5151174 Chinyanganya F. 5161230 Chakrabarty M. 20146 Chasan R. 1441257 Chen S.H. 2571184 190 Chiou C. M. 405134 Chakraborti A. 4091303 42715 Chassaing G.,218141 42 43 Chen S. T.. 218129 Chiou W.-F. 428146 6181.54 Chakraborty S. 2561118 Chater K. F. 555149 50 Chen S. Z. 203143 Chirala S. S. 3571143 144 3581208 Chakravarty A. K. 3851176 Chatterjee M. 3851176 5561168 Chen T, 450152 5551101 209 222 Chalchat J. C. 5151208 Chatterjee S. 1821276 Chen T. S. S. 553112 13 14 Chirva V. Ya. 6781156 183 Chalker B. E.. 2991329 Chattopadhyay A. 1811204 5561176 Chisholm J. D.. 4291115 Chamberlin A. R. 218170 635130 1821280 285 Chen W. M. 2571160 Chistner D. F. 109155 Chambers. A. F. 602193 Chattopadhyay S. 1811184 2571161 Chen X. 5181470 Chitkul B. 97190 203145 Chambers M. S. 650132 39 164 Chen X. J. 5161279 Chittawong V. 911100 Champaneri H.R.. 4751103 Chatzopolou P. S. 5 151165 Chen X. K. 6781176 Chiu C. T. 5211728 Champe S. P. 1821310 Chau J. H. L. 3861231 Chen X. M. 4081217 Chiu M.-H. 677156 57 Chamulitrat W. 1851549 Chau P. L. 5161294 Chen X.-Y. 1431164 Chiung Y.-M. 731132 Chamy M. C. 256187 135 Chau S. H. 1841438 441 1861705 Chen Y. 39133 1431164 4061117 Chmiel A, 5 13150 51 Chan C.-C. 71/46 1871741 764 5141124 5151183 5181415 Cho H. 356157 102 450125 26 72 Chan F. Y. 650155 Chaudhry A. 1821265 5 191552 6781155 4511157 Chan H. W.3 2191104 Chaudhuri S. 4511118 Chen Y. A, 4081278 Cho H. G. 411158 160 Chan J. A, 3011467 Chaudhuri S. K. 1591115 6791205 Chen Y. C. 5221759 760 Cho K.-H. 3851187 Chan K. L. 1601135 Chauviere G. 618174 Chen Y.-J. 2981205 Cho S.-J. 71/30 31 5201641 Chan T.Y. 406192 Chauvin M. 4091287 4101434 Chen Y. P. 131152 Cho W. O. 411158 160 Chan Y.-Y.. 2016 67. 406192 Chavakula R. 3001387 Chen Y.-P 6791214 Cho Y.-S. 5901138 139 5891127 Chavan S. P. 5181445 Chen Y. X. 1431171 Chobanov N. G. 4091342 Chanatry J. A.. 217117 Chaves M. C. D. O. 651161 Chen Y. Y. 406191 Chodounska H. 3851132 Chand T. 159179 Chavez J. P. 1611233 Chen Y.-Z. 20216 5171327 Choe Y. S. 3841125 126 140 Chandon M. 406153 Chavez R. G.,10195 Chen Z. 4071153 5171313 5201610 Choi C. Y. 356168 Chandra A.. 71/10 Chayet L.,602177 676123 Choi C. Y. C. 1811165 Chandrasekharan J. 405124 Chazin W. J. 109165 Chen Z. Y. 1871744 Choi D. 141139 6031127 128 Chanegriha N.. 5141137 Che C. T. 72151 731140 4081226 Chenal T. 5181446 Choi H. D. 3321176 Chang B. 3861225 Che J.406176 Cheng A. K. L. 1871720 Choi M. S. 2571169 Chang C. 677171 72 73 74 Cheah K. Y. 1841505 506 Cheng. D. 406190 5191558 Choi S-A. 5181433 Chang C. C.. 5211739 555173 Cheav. S. L. 4751105 Cheng D. L. 1611228 Choi S.-N. 401142 Chang C. J. 450122 4511106 Cheda A. K. 405128 Cheng H. 676111 Choi Y. C. 1871765 766 767 Chang C.-J.. 731183 81116 553112 Cheeke P. R. 660175 Cheng I. W. 159144 Choi Y.-H. 9152 55 13 14 15 5561133 Chelmobit’ko V. A. 405133 4071180 Cheng J. 71127 65018 Choi Y. S. 4081272 Chang C. P.. 40186. 5211728 737 Chelucci G.,5191551 556 Cheng J.-F. 2911146 Chojnacki T.. 142175 Chang C. T. 474142 Chemla F. 5211701 Cheng J. K. 1611228 Chommadov B. 4071176 Chang F.-C. 61715 618153 Chemli R. 82126 47 Cheng J.-T. 20130 Chordia M. D. 2571178 Chang F.R.. 4071177 Chen A, 142177 78 79 88 Cheng K.-F. 428199 Chory J. 10196 97 Chang G.-Y. 71142 Chen B. Z. 4071154 Cheng K. L. 1871721 Choshi T. 3011461 462 427111 18 Chang H. 47413 Chen C. 3841127 41 11461 Cheng X. 2571181 Chou C. C. 4071124 Chang H.-C.. 6791214 Chen C. C. 731152 741212 4061105 Cheng X.-C. 4631102 555151 52 53 Chou H. M. 6031103 Chang ti. L. 4071131 4631105 5221755 756 759 760 Cheng Y.-C. 71127 28 30 31 Chou H.-N. 463151 5561147 Chang J. 635138 Chen C. F. 1611249 Cheng Y. S. 1611209 256185 86 Chou J. C. 96152 Chang J. S. 3011442 Chen C.-F. 20145 428146 5891127 102 Chou T. 3011426 6361129 Chang K. 4071189 618154 650127 6791208 Cheng Y.3 72198 6791220 Chou. T.-C. 20161 4281101 5191499 Chang L. C.. 383122 Chen C. H. 3321140 405134 Cheng Z. 5191510 500 501 Chang M.D.-T.. 3321185 186 4 101417 650127 Chengappa S. 10180 Chou W.-C. 659116 372172 Chen C.-H. 650126 Chenieux J.-C. 20112 Chou Y.-L. 428138 Chang M. H.. 72197 Chen C. K. 4061105 Chern C.-Y. 5891127 Choudhary M. I. 971100 256196 Chang M. N.. 183J367 Chen C. M. 406139 Chernenko G. F. 1611235 255142 3571178 Chang N-C. 5211728 737 738 73 9 Chen C. S. 1871788 Cheron M. 1101101 Choudhry S. C. 46215 Chang P.-C. 554119 Chcn C. T. 47416 Cherry P. C. 331193 3321180 Choudhury A, 1811184 Chang P.-K. 5561162 Chen C. Y. 4071165 Cheruvallath Z. S. 25711 75 Choudhury S. R. 1811202 Chang P. S. I851594 Chen. C. Z. 5201611 Chester S. T. 3917 Chowdhury A. R. 5141110 Chang Q. 677164 Chen C.-X. 6781175 Chesters N. C. J. E. 371110 12 13 Chowdhury B. K. 20151 42715 Chang S.-J.2991276 Chen D. F. 741216 217 Cheung M.-K. 428199 Chrest F. J. 635138 Chang S. L. 4091313. 321 Chen D. H. 677164 Cheung Y. K. 1841438 439 440 Christeller J. T. 97183 Chang T. K. 20130 Chen D. Y. 6771107 1871741 764 Christen M. 1801142 Chang Y. J. 677159 Chen F. 4071138 Chevalier D. 6511111 Christen P. 4511126 5221800 Changfu X. 3011490 Chen F. H. 1611247 Chew F. C. 971115 Christensen B. G.,330144 Chao C. C. 4091322 Chen G. 42713 Chew S. Y. 5191520 522 523 Christensen D. J. 602175 6031102 Chao L. 3841101 Chen H. 731162 1611276 3011426 Chhabra B. R. 1621305 105 Chapa A. M. 63517 5 17/33 7 Chhabra S. C. 30319 Christenson L. P. 981166 Chaparro A. 256187 Chen H.-J. 39142 43 428177 Chi D. Y. 383126 3841126 3851140 Christiansen C. 1591117 5161235 Chapell B.J.. 6361112 Chen H.-X. 71127 Chi H. J. 514193 Christianson D. W. 1431149 Chapkin R. S. I801138 Chen I. S. 405116 34 4071165 171 Chi Y.-I. 141137 Christie N. D. 3011485 Chapman D.. 1801121 182 4081214 428145 474124 42 Chiacchio U. 65917 Christie W. W. 179133 1801109 Chapman G. W. 5141119 Chen I.& 20115 30 741247 270 Chiadmi M. 3851143 1811167 215 1851589 599 Chapman R. F. 9616 61718 17 19 618134 52 53 Chiang H.-C. 2011 159144 47413 1861624 625 626 627 629 631 Chapman S. R. 4081268 677170 Chiang H.-H. 2421124 636 640 671 1871763 764 768 Chapman-Smith A. 356124 Chen J. 5181453 Chiang M. Y.,2571195 3001342 Christner D. F. 109164 Chappell J. 14115 6 38 1431143 Chen J.-H. 618137 38 Chiang Y. C. P. 1831367 Christoffersen R. E. 1421113 146 241142 513144 602124 Chen J.J. 405116 4071182 4081214 Chiaroni A. 39145 25711 72 Christophersen A. S. 4081235 6031130 131 132. 133 Chen J.-L. 463165 Chiasera. G.,2571208 3001370 4 1 01400 Chappey 0..41 11448. 453 Chen J. M. 406159 46411 I4 Christophersen C. 3001391 428169 Chapuis. C. 5211693 Chen J. R. 1591103 Chiba T. 1841515 6361128 6781199 Chapuis. J.-C.. 2971169 Chen K. 741246 Chibisova T. 474138 Christopoulou. C. N.. 1861618 619 Chardigny J. M.. 1821295 296 Chen K. S. 4071177 Chicharro M. 40511 620 1841493 Chen K.-T. 20145 Chida M. 1431145 Christov V.. 401100 Charles B. 5 161257 Chen L. 4061104 5171337 Chida N. 428182 4511146 651191 Chrzanowska M. 4071120 Charlier. H. A, 141117 Chen L. J. 4071143 103 Chu C.-S. 588135 Charlton J. L..731196 Chen M. Y. 5181422 Chien H.T. 5141128 Chu F. S.,5561166 Charlwood B.V. 513152 602119 Chen P. 5 151181 Chifundera K. 741274 Chu G.,5151166 650143 44 6031115 119 Chen Q.. 408/283 518l410 Chihara M. 1821257 4641109 Chu G.-H. 635155 Charlwood K. A.. 602119 Chen Q. H. 5201607 Childs S. R. 4091350 Chu G-L., 5151168 169 170 Charnas R. L.. 3321137 138 Chen Q. P. 474110 475179 Chimichi S. 72185 Chu H. Y. 5201609 Charnock. J. M. 96145 Chen R. H. 5561171 Chin C. K. 3571178 Chu J. 4291118 Index of authors cited 1-53 Chu M. 4291129 Coca G. P. 5211699 Chu X. J. 1831356 357 Cochran J. E. 731190 Chua N.-H. 141134 Cochran S. 1841446 Chubinidze D. V. 5161276 Cockburn A, 331163 Chubinidze V. V. 5161276 Codina C. 30311 8 9 20 Chuck J. A, 2561109 35516 Coello-Coello J. 37 1149 Chueh F.4071138 Coenen H. H. 1841463 Chugtai M. I. D. 82119 Coeregh I. 5201646 Chuiko V. A, 5191514 Coetzee P. S. 3011430 Chulalaksananukul W. 5161286 Coffman H. R. 141150 602129 94 Chulia A. J. 255/74 Cofield D.. 3001380 Chulia S. 4071187 Coggins J. R. 4511118 Chuliam A. J. 5221763 Coghlan A, 971107 Chunchatprasert L. 589/68 Cohen D. E. 971120 Chung C. K. 635/52 Cohen E. 4101414 Chung H. S. 4751100 Cohen G. 2431191 Chung M. I. 5221764 Cohen J. D. 9/69 Chung Y. J. 5201643 Cohen P.,463137 Chunha W. R. 1601189 Cohen S. 1881881 Church D. F. 1851532 Cohen S. N. 554119 Church N. J. 219193 94 Cohen T. 371122 Chye M.-L. 141134 Cohen Z. 1881880 881 Ciara M. R. 383122 Coiffard L. 463178 Ciaroni A, 159139 Cojocaru M. 98/196 Ciavatta M.L. 255115 3001412 Colacchio T. A, 4091323 Cicchi S. 39115 17 635111 12 13 Colada M. I. 4101410 Cichacz Z. 2981191 192 Colbv. S. M.. 142198 Cid M. M. 4071159 Colcfausure G. C. 9/66 Ciereszko L. S. 463166 Cole B. J. W. 677178 Cifelli S. 109150 Cole M. 33012 36 39 Cihlar R. L. 3571150 Cole M. D. 981164 Cimanga K. 427117 Cole S. C. J. 372178 Cimarusti C. M. 331153 54 Coleman A. A, 82175 Ciminiello P. 2981201 234 2991319 Coleman A. W. 513133 Cimino G. 255/15 2971154 Coleman J. E. 2981180 428148 3001364. 408 412 413 3011421 Coleman J. P. 3851168 422 423 Coleman K. 331158 59 121 Cimino G. 3571134 Coleman P. J. 3001356 Cimis G. 3861225 Coll. J.. 3581198 Cintas-Moreno P. 218145 Coll; J.'C. 3001355 3011454 465 Cioffi C. L. 3021495 3851169 428186 Cioffi E.A, 356138 Coll M.-D. 589158 Cioni P. L. 5161233 Collh J. 463186 Cipres I. 5181446 Collado I. G. 1601155 Ciufolini M. A, 3011463 464 Colletti S. L. 109177. 79 4641118 5901132 Collier P. J. 5891116 Ckless K. 4071132 Collin G. 514180 108 515/172 189 Claeys M. 427117 Collington E. W. 5201649 Claire C. 463178 Collins J. C. 2981218 4081282 Claon P. A, 5161284 285 Collins M. A, 384189 Clapp C. H. 1841486 Colombo A. L. 554145 Clardy J. 971100 46216 8 463195 Colombo M. L. 4061114 4071166 102 5181485 5561200 Colson K. L. 1101109 Clark A. M. 2581240 Colwell L. 5561176 Clark C. W. 589162 Comai K. 1851581 Clark D. A. 39/52 53 Comar D. 219198 Clark G. S. 5171395 Comb D. G. 463/31 Clark W. D. 2981178 Combaut G. 3011447. 456 Clark W.M. 428182 Combes D. 5161286 Clarke S. N. 4101367 Combrink K. D. 741254 255 Clarke T. 1831348 Cometa M. F. 5211717 Clarkson J. R. 5151197 Comins D. L. 20137 5901140 Clase J. A, 5551122 618149 50 63411 651162 63 67 Clastre M. 142157 602153 Commercon A, 5901134 Clauss M. 3571138 Comoe L. 20112 Claveria L. E. 4071199 Comotti A, 5191548 Clayton M. T. 1821261 Compagnone R. S. 1591120 Clayton S. C. 650134 2991277 Clayton W. 1811238 Compton D. R. 5221812 Cleland W. W. 602133 Comte G. 255174 Clements S. L. 981189 Conard J. L. 39165 Clerici F. 41 11447 Concepcion G. P. 2991262 Clerivet A, 981185 Condoret J. S. 5161286 Cleve A, 3851144 Cone M. C. 372187 4511150. 158 Clevel T. E. 5561161 162 166 167 159 555156 58 169 Confalonieri G. 513118 Clifton I.J. 2431190 3321189 Conforti F. D. 1851608 372174 Coniglio J. G. 180178 Clissold D. 180183 Conkerton E. J. 1881813 Clive D. L. J. 1601160 635165 Connolly J. D. 72169 1621345 Clouse S. D. 10170 77 78 81 82 5 171346 6781127 95 Connolly S. 2971152 Clouston P. D. 4081210 Connors N. C. 555147 Cmielewska P. C. 4081281 Conover M. A, 159148 2991249 Coan P. S. 300/363 Conroy E. 4071197 Coates J. B. 3321178 179 Conserva L. M. 2019 475/55 61712 Coates R. M. 142196 107 241139 Conte M. H. 1851583 75 5191489 490 Conte M. R. 2991307 Cobar 0. M. 2571223 3001367 368 Conti A, 5151178 1-54 Natural Product Reports 1997 Convigton C. D. 475170 71 Cook D. R. 406150 Cook G. R. 650149 651190 Cook I. F. 2431192 Cook J. M. 428133 37. 55. 56 589145 Cook Jr.J. C. 911 Cook L. R. 463141 Cooke. C. J.. 981203 Cooke; D. 3841109 Cooke S. T. 10819 Cool 1.G. 159198 116 513138 Coolbaugh R. C. 1431214 241125 27 64. 81 Coolbear T. 602115 Cooney B. 971119 Coop A, 4081230 Cooper A. J. L. 217115 Cooper C. 1881857 Cooper D. 331163 Cooper D. I. 331162 Cooper M. M. 42711'9 Cooper R. 618155 56 660171 677179 Cooper R. A, 660159 65 69 Cooper R. M. 981179 Cooper T. G. 39149 1861698 Copes 1.C. 1861633 Coran S. A, 71114 15 72185 Corbett D. F. 330138 41 331194 Corcoran D. 3581234 Corcoran E. E. 2971113 3001340 Corcuera L. J. 981146 Corda M. 4101380 Cordeiro R. S. B. 71143 Cordell G. A, 20159 72182 83 89 95 731140 255122 256199 123 125,126 2571216 4071178 588141 618177 78 6781138 139 140 141 143 144 Cordero F.M. 39/15 17 635111. 12 Corey E. J. 15818 159184,1611214 1811172 1831335 2421169 2991286 5201610 5891118 119 120 122 123 650133 676111 Cori O. 602197 Coria F. 4071199 Corley E. 1831425 Corliss J. O. 46214 Cornell L. 296160 3011465 Cornett C. 6781192 199 Cornforth J. W. 356122 23 Cornforth R. H. 602170 Cornish K. 6031108 Correia C. R. D. 256179 636196 659110 Corsaro A. 65917 Corsaro M. M. 5161271 6771110 Corserva L.M. 731143 Cort J. R. 428166 Cortes D. 731168 406179 4071187 Cortes J. 356176 3581221 450120 Cosentino. 1.M.. 71144 Cosgrove J. P. 1851532 Cosimelli B. 72185 Cossy. J. 1601169 1611263 Costa J. 39/36 Costa P. R. R. 721110 5181411 Costantino V.2971138 140 Costello C. E. 96121 Cosulich D. B. 450183 Cote J. 3841130 Cotgreave I. A, 4071188 Cotrim H. C. 5151195 Cottando C. I621296 Couch D. B. 4091316 Couderc F. 1871777 Coudret J-L. 5191502 Couillerot E. 20112 Couladouros E. A, 2561148 257/183 Coulais Y. 4081256 Coulombe R. A. 660172 73 Coulson A. F. W. 3311112 3321135 Coulton S. 3311122 Counter J. A. 5211674 Courseille C. 383128 Court J. J. 618148 Court W. A. 450179 80 Courtney A. K. 428177 Courtois D. 5211692 Coussio J. D. 475189 95 Coustal S. 3851146 Coutterez C. 2571187 Couture A, 650116 Coval S. J. 159148 2991249 Cove 1. H. 372183 Covey D. F. 3851137 138 151 152 Covey J. E. 1841501 Coville P. F. 5891109 Cowan A.K. 1431184 185 Cowden W. B. 39150 51 52 53 Cox A. D. 1811210 Cox. D. A,. 3311109 Cox E. D. 428133 Cox P. J. 6791217 Crabtree G. R. 109167 Cragg G. 241155 2421177 Crain S. M. 4091330 4101382 Cramer C. L. 141145 6031136 Cramer F. 602169 Cramp R. 3311116 Cranmer A. M. 3571180 Cranmer 111 L. D. 463136 Crast Jr. L. B. 3311113 Craveiro A. A, 5161239 256 Craven L. A, 514192 Cravotto G. 2561151 2571185 2581242 475198 Crawford I. P. 4521183 Crawford L. 203151 Creach A. 1801147 3571171 Cremlyn R. J. 5201587 Crespi-Perellino N. 428184 Cretney W. J. 67611 Creveling R. K. 1881868 Crews P. 158123 28 1811218 2971159 29811 77 178,2981241 261 268 272 4631102 106 6361127 Criado 1.M. 5551114 Criddle R.S. 3561100 Crighton C. 971118 Crilley M. M. L. 1821314 Crispino A, 2991265 308 309 3001364 Critcher D. J. 2971152 Crock J. E. 142199 Crockett R. 5191497 Croisy A. 618180 Croker S. J. 2421159 2561114 Crombie L. 1831358 360 1841469 470 1851552 570 571 1881886 3 5711 54 Cronan J. M. 2571227 3001358 Cronan Jr. J. E. 355110 12 356124 25 28 29 37 43 47 56 57 58 59 3571163 Cronstein B. 4111452 Crook S. 1831403 Crooks P. A, 4101390 Croom D. K. 5901137 Croom Jr. E. M. 5161254 Croom Jr. W. J. 3916 7 9 63516 7 Crosa J. H. 463125 Cross B. E. 240116 17 18 20 23 53 72 241171 2421184 2431195 Croteau R. 14112 7 11 12 142191 92 97 98 99 100 101 105 106 107 108 109 110 111 129 130. 1431197 198 208 209 210 1441251 252 241149 513141 43 45 49 5 14/63 5 161272 274 5 161274 5 191489 490 562 5201656 5211677 602116 52 66 60311 17 118 Croteau R.B. 142196 Crothers D. M. 109158 Crouch N. P. 218169 3321178 179 193 Crouch R. C. 296170 3021496 589156 Crout D. H. G. 1801142 Crowell D. N. 60115 Croxen R. 141129 Crozier A,. 9160 241168. 101 102 Crul J. L. 406148 Crull G. B. 5201589 Cruskie Jr. M. P. 3011488 489 Cruz H. N. 71143 Csakai Z. 384146 48 Csaky A. G. 1831383 5181412 423 Csanadi J. J. 384190 Cseko I. B. 5141100 Csorvassy I. 4081229 Cuadrado C. 401123 125 131 Cudic M. 5191565 Cuellar R. 141138 Cuerva J. M. 39172 262 Cueto M. A. 141118 Cui C.-B. 428162 Cui L. 406193 4081252 6781135 Cui Y. X. 2571214 Cui Z.6781155 Cui Z.-H. 427124 6791201 Cullen T. 4081275 Culpepper J. S. 2981213 Cumming J. G. 29811 71 Cunat A. C. 5211698 Cundliffe E. 555181 Cunha A. N. 5151215 216 Cunliffe W. J. 1441242 Cunnane S. C. 1871744 Cunningham C. L. 4101376 Cuny G. D. 40178 Cuomo V. 463188 99 Cupp-Vickery J. R. 555179 Cuq F. 981156 Curley Jr. R. W. 219195 Curotto J. E. 256177 Curran D. P. 5181431 5201647 5891128 5901129. 636111 1 Curran T. D. 3851139 Currens M. J. 6791206 Currie G. 2971129 3011466 Currie G. J. 1871781. 782 Currie S. A. 330133 43 45 Curtis J. M. 296163 65 3011427 Curtis P. J. 241117 Cushing T. D. 428164 Cushman M. 384185 38511 78 589169 70 Custodio R. 660154 Cutshall N. S. 1611255 Cuzzoni A.555183 Cy J. P. 5161301 Cybulska B. 1101100 101 Czarniecki M. 159155 2991250 Czarnocki Z. 405118 Czempinski K. 141128 Czerwinski A, 1 IOIIOI Czygan F.-C.,401104 514154 635169. 75 76 78 82 Czyzewska E. 42713 D da Cunha A. P. 5151154 Da-Cunha E. V. L. 4081223 651161 Daffe M. 356186 87 93 Dagaut J. 1871760 Dagnino D. 371142 D’Agnolo G.. 356141. 42 Dahlke B. J. 4751106 Dahuron N. 5201624 Dai L. 5151163 Dai S. 406184 4071140 141 142 Dai W.-M. 109153 Dai X. P. 20214 Daido M. 677195 Dailey Jr R. G. 450180 Daimon A, 741222 Dale C. M. 1831351 Dale S. 141143 D’Alesandro C. 3851181 Daley D. C. 650133 Dalietos D. 296150 Dallery L.. 384195 Dalley N. K. 1611276 Dallmann H. G. 1851573 1891905 Dallner G.142175 90 60116 Daloze D. 96118 296154 2981208 462116 618126 6361132 650155 Daly J. W. 20133. 34 39162 40183 635141 651175 660150 Daly M. V. 4101385 Damberg M. 44915 6 4511140 D’Ambrosio M. 1811236 1821241 2571207 208 296182 3001369 370 463188 46411 I2 Dammertz W. 4071121 D’Amours R. H. 4091289 Damtoft S. 1421115 116 117 118 119 120 121 122 123,124 125 126 5211719 720 721 745 5221749 753 778 788 790 797 799 806 Dancer J. E. 356135 Danell K. 97159 Daneshtalab M. 731197 d’Angelo J. 589196 Danheiser R. L. 475163 Danieli B. 589181 91 Danielson S. J. 356192 Daniewski W. M. 971103 1601165 181 197 677182 Danikiewicz D. 677182 Danikiewicz W. 1601181 Danis S. J. 450121 5551106 Danishefeky S. 109158 62 67 70 Danishefsky S.J. 20152 2561149 3851184 185 42811 01 Danjo H. 5171377 Danks T. N. 5201626 D’Annibale A. 5211742 Dao T. H. 5151186 Daoud W. 406154 Daoust D. 330145 Dapiaggi A. 5161289 291 da Ponte M. N. 5171374 Darbie L. G. 2571181 Darges J. 3001380 Darl G. 450153 Darnaedi D. 676141 Darnay B. G. 141126 40 Da Rocha A. F. I. 58815 Darrow R. A. 1851525 Darwish H. M. 3851142 Das B. 72168 80 84 2571153 3851206 Das P. C. 635127 Das P. R. 4291129 6781198 Das S. 1821246 Dasaradhi L. 181322 340 Dasdia T. 109124 da Silva C. S. R. 4071201 Da Silva M. F. D. G. F. 731164 da Silva M. F. das G. F. 61719 677181 Da Silva M. S. 731143 da Silva-Planeta C. 4071201 Datta A. 2571176 180 Daulatabad D.181252 253 Dauphin-Villemant C. 3851204 D’Auria M. V. 1811213 2981179 30 114 77 46411 I5 Daves G. D. 96140 Daviau T. R. 2571227 3001358 David J. M. 741236 David P. A. 1861657 David S. T. 82174 Davidson B. S. 296115 28 3011449 455 427125 Davies A. 555191 124 125 Davies A B. 555191. 124 125 Davies D. H. 555191 Davies G. J. 109121 Davies H. G. 109143 5551105 Davies J. E. D. 1831409 Davies L. R. 406196 Davies N. W. 96149 5151149 Davies P. J. 1441218 241166 2421138 Davies R. J. 651185 Davies S. G. 5201651 618147 Davies-Coleman M. T. 15813 257121 9 2991332 30013 78 30 1 I430 Davila-Huerta G. 1601122 Davin L. B. 7113 4 72154 Davioud E. 3851146 Davis A. M. 401109 Davis A. P. 384170 Davis B. D. 4511121 Davis B.E. 331198 Davis D. R. 602192 Davis F. A, 2971145 5201638 648 Davis G. D. 1431162 1591121 1601122 Davis H. M. 3571160 Davis N. E. 331183 Davis R. 618164 Davis S. C. 372177 Davis T. P. 4081209 Davison M. 3321173 3331200 Davisson V. J. 142168 69 1431164 602171 72 73 Davletina G. R. 5171381 Dawe R. D. 1871745 Dawes E. A. 3571113 Dawson G. W. 1421113 114 Dawson J. H. 5201589 Dawson M. J. 372183 85 55611 72 173 Dawson R. M. 241138 Day H. M. 5211728 Dayal B. 384155 De Alcenar J. L. 4081223 De Angelis F. 463169 Deans S. G. 514199 De Araujo-Junior J. X. 651161 de Azevedo E. G. 5171374 de Bellis P. 2571152 Debenedetti S. L. 475189 95 De Biasi S. 4091341 Debitus C. 1811179 213 2981179 220 2991266 3011419 439 476 450177 4641112 115 De Boeck B.660155 56 de Boer-Hlupa V. 602123 Debrauwer L. 6791234 Debray M. 41 11453 De Brosse C. 2981207 Debrunner B. 1611279 280 De Bruyne T. 42711 7 Debussche L. 372191 de Buyck L. 1811225 1831338 5 161230 de C. Bayma J. 255132 2561122 De Caprio J. L. 4101374 de Carlos C. 4101410 De Carolis E. 371146 de Carvalho M. G. 677162 Decker E. A. 1861681 Decker H. 553118 Decker H. 554135 43 44 Declercq J. P. 660156 De Clercq E. 3851178 de Diego J. M. G-F. 5201580 Dedon P. C. 109170 71 Dedouzy J. C. 1101100 Deem-Dickson L. 971130 Deerberg J. 218149 de Faria A. R. 636196 659110 de Feo V. 5141136 Deffieux G. 1431131 132 133 513146 47 48 Deflre A, 5201586 de Franca L.F. 255132 de Freitas A. S. W. 1841448 296164 de Freitas M. R. 4081223 de Gala S. 3851185 Degas M. 4101411 Degerbeck F. 217112 13 De Giulio A, 2971110 2991265 308 309 3001364 Degl’Innocenti A. 5 191534 Degnan B. M. 3011443 de Goede A. T. J. W. 2191121 de Groot A. 741252 971108 1431194 5181476 477 de Groot Ae. 1601177 178 16 11244 1621332 de Groot P. 96133 de Gutierrez A. N. 15811 de Guzman F. S. 4641108 Degwert U. 4511151 De Haan B. 1851601 Dehghani A, 20137 Dehmlow E. V. 650148 Dehnicke S. 5201582 Deinhard G. 450116 54 68 de Kanter F. J. J. 5211665 Deki K. 3011431 432 651172 73 De Kimpe N. 2971114 475189 651198 DeKruiff B. 110198 del Olmo E. 731202 203 291 del R. Cuenca M.731171 de la Cuadra C. 401123 125 131 Delaforge M. 109193 94 de la Fuente G.,202111 13 17 303120 58819 deLage C. 255174 Delamarche I. 1831388 de la Moya-Cerero S. 5201580 521I669 de Lampasona M. E. P. 1601170 Delaney T. P. 981204 de la Rosa R. I. 1811168 de la Torre M. C. 1621343 255164 65 67 69 70 256193 de Lange B. 5181409 Delaude C. 58812 3 Delaware D. L. 4511108 de L. Bordignon S. A, 1811191 del Carmen Reyes M. 1821309 del Corral J. M. 255147 del Corral J. M. Miguel 731291 Del Fiore G. 219198 Delforge M. 109195 Delgada G. 5141123 Delgado A. 1831350 1841459 Delgado G. 159172 618129 de Lima R. A. 5221787 Delius J. D. 4071194 dell Amico N. 159177 Dell C. 1831348 Della Greca M. 158118 1821244 6771110 Dellacassa E.515121 7 Dellar J. E. 981164 delle Monache F. 82140 61713 6791243 Delmas M. 20110 Delmond B. 5161292 Delmond D. 5211695 DeLong E. F. 1841444 2971155 Delourme D. 142162 602190 Delrot S. 141125 Delsedine M. 4081204 de Luca A. 5221787 DeLuca H. F. 3851142 Deluca M. E. 3851181 DeLuca V. 371124 25 45 46 De Lucia R. 4071201 Demain A. L. 450143 47 555196 98 99 Demandre C. 1871785 de March P. 2971122 de Marcheville H. 51318 De Marco A, 109124. 25 DeMarco A. C. 2191103 De Marino S. 3011476 Demarne F. 5141131 5151143 203 213 5 161245 DeMattei J. A. 463141 Dembitsky V. M. 180175 76 18 11187 188 189 190 223 Demel R. A, 110198 Demetriadou A. K. 5551125 Demharter A. 5181419 Demin P.M. 1801127 Demirbuker M. 1861664 665 666 Demirdamar R. 5181437 Demissew S. 513140 Demnitz F. W. J. 159154 474121 de Morgensztern C. M. 406161 de Mori M. 4081205 Demoulin V. 296154 462116 Demoz A, 1831415 Demuner A. J. 741238 De Napoli L. 2991278 DenariC J. 6511111 Denayer R. 513124 Denbow C. J. 141145 6031136 Deng C. H. 1611234 Deng F. X. 1611254 Deng G. 3851170 Deng J. 296134 5201627 Deng Q. 5171309 Deng S. 4071153 Deng Z. 4081212 5551116 Index of authors cited Deng Z. J. 405121 Dewick P. M. 7116 14111 1431153 Denhardt D. T. 602193 154 372155 55311 5 Denholm A. A. 677183 de Wit D. 1811225 1831338 Deniau E. 650116 Dey I. 6791213 Denike J. K. 3851155 Deyl Z. 1851610 DeNinno M. P. 384139 Dezeny G.5561176 Denis J. N. 2571187 Dezeuze A. 514195 Denisenko 0. N. 405133 4071180 Dhal R. 72172 73 102 741257 258 Denisenko V. A, 741269 Dhar K. L. 6791225 Denkova R. 4091343 Dhar R. K. 5191544 Denmark S. E. 411156 Dharmasena P. 589168 Dennis D. T. 240112 241154 602196 Dhe-Paganon S. 141149 Dennis J. W. 635126 Dhimane H. 39167 635/53 54 Denny W. A. 108115 Dhonge V. D. 5181445 Denoya C. D. 450135 D’Honneur G. 406151 de Nys R. 2971119 Dhotke U. P. 5191539 540 541 de Oliveira A. B. 1611229 2561129 542 de Oliveira D. F. 5171382 Diakite D. 428149 de Oliveira E. R. 5181467 Diallo A. O. 4071160 428187 de Oliveira F. 5211746 Dias L. C. 39173 40195 de Oliveira G. G. 1611229 Diaz F. J. 81/12 de Pascual-Teresa B. 731151. 202 Diaz J. G. 731171 2561119 203 Diaz J.G. 15811 1601184 189 195 Depentori D. 296182 1621304 Depew K. M. 20152 Diaz-de-Villegas M. D. 5201635 Depezay J. C. 180196 1821318 Diaz-Lanza A. M. 5221792 Depoorteere I. 109192 Di Blasio B. 2991278 de Pooter H. L. 5161230 Di Braccio M. 4751115 Derbesy M. 5161288 Dick M. R. 40186 Derewenda Z. S. 356139 Dicke M. 97184 87 88 De Riccardis F. 2991322 3011480 Dickens J. C. 96137 3851209 Dickey R. W. 296170 3021496 Derien A, 463178 Dickinson A. H. 4081261 de Rijk T. 1811225 1831338 Dickinson S. D. 4101376 DeRisi C. 650140 Diczfalusy U. 1801133 De Roeck-Holtzhauer Y. 463178 Didillon B. 5161301 De Rosa M. 180193 1811207 Dieffenbacher A. I79121 DeRosa M. 450156 60 63 Diehl B. W. K. 1871722 De Rosa S. 159151 2971110 Diekelmann G.179142 2991257 258 2991265 308 309 Dierashvili M. 218123 3001364 Dietel P. 1821273 1831389 Derrick I. 4101416 Dieterich P. 2191112 113 Derridj S. 660157 Dietrich A, 513131 Derrien M. 1101103 104 Dietrich H. 514172 Deruere J. 142181 Dietrich H.-J. 4291117 Dery C. V. 555148 Diez A, 589172 86 Desai H. K. 20218 9 12 203121 Diez D. 255151 de Samblanx G. W. 981168 Diez D. 159158 De Schrijver R. 1851588 Diez-Martin D. 1591102 Descoins C. 3581198 3581202 Di Fazio C. 4101385 Descomps B. 1871744 Digate R. 450135 De Sena C. 2991309 Digel M. 82144 Deshpande M. S.,4291113 Di Giulio A M. 4091324 341 Deshpe P. P. 475174 75 Dillon M. P. 659115 Deshpe V. J. 4751111 Dillon V. M. 981191 de Silva E. D. 2981180 187 Dils R. 3581226 227 3011433 428148 618122 Dilts S.B. 514158 de Silva J. 10180 Dimach M. B. 971116 de Silva L. B. 255153 Dimitri-Konaklieva S. 5191486 de Simone F. 677158 Dimitrov V. 5201581 590 Desjardins A. E. 1431155 156 157 Dimke M. 5191538 188 189 Dimroth P. 5561158 Deslauriers H. 5141108 5151189 Dinan L. N. 3851205 Deslongchamps P. 2561133 Ding L.-S. 20216 Desmaele D. 589196 Ding W.-D. 4641113 Desmarais D. 555148 Ding X. 82170 Desoky E. K. 475153 676144 Dini F. 1621350 296178 d’Estaintot B. L. 108111 Dini F. 463155 56 57 60 61 63 de Suzzoni S. 2571193 64 de Tommasi N. 677158 Dini Z. 1611250 Dettner K. 96122 23 24 1421127 Dionne P. 38315 128 5211718 Diosady L. L. 1841497 498 503 Detzel A, 971139 Dirig D. M. 4081269 Deus-Neumann B. 371126 Discafani C.4641113 Deutzmann R. 372161 Dischinger Jr H. C. 5561167 Devagiri G. M. 474116 Disselkamp R. 21714 Devalla S. 1831340 Dittrich B. 141132 Deverre J.-R. 588112 Dittrich H. 371134 Devi S. 82122 24 27 29 31 Divakar S. 1861696 5181435 de Vivar A. R. 1601162 5171349 52015 78 579 659121 23 Dix T. A. 1851540 Devlin F. J. 5191572 Dixon B. R. 1611214 Devlin J. P. 6511119 Dixon R. A. 141136 Devraj R. 589169 70 Diyabalanage T. K. K. 6791216 Devrauwer L. 1611271 Djerassi C. 1811193 194 1841455 de Vries A. H. M. 5201619 241119 2971156 299131 7 318 De Vries T. J. 4091325 332 359 676122 . De Waal A. 371141 Djermanovic M. 1621313 de Waard P. 1811225 Djermanovic V. 1621313 1-56 Natural Product Reports 1997 Djuric V. J. 4101377 Djuricic B. 41 11454 Dmitrenok A.S. 2991323 324 3011448 Dmitrienko G. I. 555157 Doan H. D. 1821295 296 Dobler S. 96111 659143 Dobner B. 1841464 Dobson G. 1861636 Dockerill B. 2421182 2431200 D’Ocon M. P. 4071187 Doddrell D. M. 5551124 Doemling A. 3861241 Doenicke A. 4091356 Doepke W. 303112 13 Doerffling K. 1431187 Doerner P. W. 141131 Dogan O. 5201640 Dogbo O. 602188 Doherty A. 3331198 Doi M. 296142 3011441 428163 6 181j8 Doi Y. 158124 296176 3011431 356167 651173 74 Doke N. 6031126 Dolan S. C. 241176 Dolenga M. P. 3861225 Dolidze A. V. 5161304 Doller D. 651/85 Dolling U.-H. 3841129 Dollmann B. 5211705 Dolmazon R. 255117 18 Dolz H. 1611206 Dominguez C. 1831383 Dominguez D. 406198 100 102 103 4071159 Dominguez X.A. 731141 741271 2 72 Dommisse R. 741252 Domoto H. 731161 Domoto N. 462121 Donadio S. 3581220 450119 554123 555171 72 76 80 Donath J. 1431179 180 181 Donato A. 5161300 302 Donbek D. L. 303114 Dondoni A. 6361125 651189 92 Dong H. 1831356 357 4511155 Dong H. Q. 159181 Donike M. 3841124 Donovan C. M. 2561139 Donze C. 513133 Doonan H. J. 6031121 Doonan S. 602132 6031121 Dorado J. M. 1611257 Dorado M. M. 731130 741261 262 Doran J. C. 331186 Doran P. M. 203148 49 Dore J. C. 401120 635179 Doring D. 1621347 Dormanen M. C. 3861216 Dorofeeva 0.V. 4751108 Dorow R. L. 218133 Dorsaz A.-C. 2981192 193 Dorta R. L. 3851191 Dosanjh G. 5191525 Dosch D. C. 555147 Doskotch R. W. 255129 30 31 Dosoretz C.G. 1851562 Doss G. A. 2991318 dos Santos E. N. 5191515 dos Santos M. L. 5171315 dos Santos P. F. 5211660 Dostal J. 4071167 168 Dostal K. 4071169 Dotson K. D. 1851602 Douay D. L. 5191496 Doubek D. L. 203129 2981194 195 218 240 3011485 Doughty K. J. 97176 77 Douglas D. J. 463170 Doumenq P. 1811179 Doussot J. 384195 Dowd P. 5181466 Dowd P. F. 3581195 Down G. H. 241174 Downing D. T. 1821249 Doyle F. P. 330113 Doyle M. P. 721111 65911 Doyle T. 109169 1101109 Doyle T. W. 109155 63 64 428193 5561129 Drach V. S. 3851195 Dragan V. A. 159167 Drak J. 109158 Drake D. J. 3321193 Draper P. 356188 3851171 Drautz H. 5561132 Dreboldt S. 981170 Dreher R. K. 356/62 Dreikhorn S. 256177 Dress R.K. 6361119 Drevon C. A. 1831419 422 Drewes S. E. 741245 5181426 Dreyer G. B. 475168 Drieze J. M. 4101436 Droescher P. 384197 103 Drouet P. 1881883 Drozdz B. 971103 1601165 181 1611205 Drukarch B. 4091328 355 4101403 Du H. 6361109 Du L. 372166 Du X. 5191512 Du Z. 1841517 Duan H. 5151145 Duan J. J.-W. 463141 Duan Z. 401109 Duarte A. 1621343 256193 Duarte J. 4071199 Duax W. L. 3841122 Dubacq J. P. 1871785 DuBay W. J. 513110 589198 Dube D. 71146 Dubery I. A. 981158 Dubois J. 2571177 Dubose K. K. 20141 Dubowchik G. M. 3851183 Duce I. R. 109146 Ducharme Y. 71146 Ducrot P.-H. 5561190 Duddeck H. 1101105 383120 21 635188 6781195 Duddeck W. S. 47412 Dudley R. L. 1821306 Dudson E. J. 109121 Dueben B.D. 96136 Dueker S. R. 660164 Duenas J. 2561130 Duester G. 1441237 238 Duffault J. M. 1821316 Duffey S. S. 97179 Duffield A. R. 255138 Duffin G. R. 55318 5561185 Duffin K. L. 1871779 Dufresne C. 203129 2981195 3011485 5221811 Duh C. Y. 2571195 296180 3001342 474142 Duhamel L. 5211709 Duhamel P. 5211709 Duhan S. P. S. 5141112 Duine J. A. 141123 602123 Duke C. C. 4291130 Duke R. K. 4291130 Dukes D. 3841105 Dumas F. 1441247 Dumas J. 180196 Dunca J. H. 3011487 Duncan A. J. 514166 Duncan J. 450122 Duncan J. D. 241144 Dung N. X. 514188 89 90116 117 125 126 128 132 134 5151187 5 171351 Dunkel R. 589180 Dunkle E. 2191119 Dunlop P. J. 5161262 Dunn M. K. 203152 Duo L. 96149 Dupont L.5191532 Duque C. 2991301 302 5171326 Durand X. 218163 Duran-Patron R. 1601155 Durant A. 651165 Dureault A. 1821318 Durette P. 3861225 Durley R. C. 2421176 DuroviC R. 635166 Ehlers D. 47411 7 Elvevoll E. O. 1881843 Eto H. 463194 101 Durrani S. 41 11462 Ehmke A, 96/11 659143 Elyakov G.B. 296131 4641110 Etoh H. 1611274 Durst F. 1891902 Ehret C. 5211692 El-Zayat A. A. E. 1821310 Euler K. L. 588110 Dusci L. J. 401130 Eibl H. 1881858 Emerson D. L. 5901137 Evans D. A. 218133 68 6361115 Dussault P. 1851542 Eibler E. 40191 Emiliano A. 181/153 234 1841449 Evans D. R. 372183 Dussault P. H. 1851541 Eich E. 721122 Emken E. A. 1841467 468 477 Evans J. R. 331172 Duthaler R. O. 21713 Eicher T. 1621339 1861632 633 691 1871780 Evans M. B. 1801116 Dutkiewicz G.401140 Eick S. 1851592 Emmerling M .,6 18164 Evans M. G. 5901137 Dutra-Behrens M. 406167 Eilert U. 20128 372162 Emori E. 5211663 Evans P. H. 5161259 Dutschewska H. 401101 635166 Einhorn J. 1821316 3581198 Emslie N. D. 5181426 Evans R. 240115 241135 40 Dutta P. K. 1811184 5561190 Enache L. A. 3021494 3851198 2421181 182 197 Dutton C. J. 5551112 113 Eisenach J. C. 40519 Encinar J. M. 5191505 506 507 Evans T. A. 20125 32 Dutton H. J. 1861669 Eisenbach N. 475149 Enders D. 158113 Evestigneeva R. P. 180166 Duvaldestin P. 406151 Eisenreich W. 602158 Endo A, 141146 159143 Evidente A. 981153 154 155 Dwaihy R. L. 39144 Eisner T. 6361134 65011 7 660148 Endo K. 5221776 5 1612 71 Dwek R. 10817 Eissenberg T. 4101435 Endo M. 2981227 4071184 Evstatieva L.N. 1611285 Dwight R. 46218 Ejeta G. 981149 Endo T. 142170 71 72 15816 Ewing D. F. 3571113 Dwivedi S. P. D. 82130 34 Ejima D. 463127 602163 Ewing E. E. 1441218 Dwivedy I. 3841123 Ekdahl A. 463186 Endreb S. 371148 58814 Ewing J. C. 1851532 Dworkin S. I. 4091350 Ekimoto H. 3001402 4641116 Engel M. H. 3011442 Extire M. 741217 D’yachuk 0.G. 2991323 Ekundayo O. 6031115 120 Engewald W. 5 151209 Eynard T. 1841492 493 D’yakonov A. L. 20149 50 618163 El-Ahmad Y. 4101397 Engle C. A. 3331216 Ezer N. 5 161229 Dyas L. 101103 El Akawi Z. 1441248 Engler T. A. 741254 255 Dyck B. P. 5201583 Elangovan S. P. 5191573 Englert E. 97168 Dykstra L. A. 4091298 310 El-Ashmawy I. M. 4091338 Englert J. 6781197 Dyulgerov A. S. 5141135 el-Batouti N. 5191532 English A. R. 3311105 F Dzhazin K.A, 1621307 322 325 Elbein A. D. 39116 20 38 48 Englund F. B. 971128 ~~ ~ Dzhenilev U. M. 4081227 97156 6511113 Englund F. O. 5151207 Dziadulewicz E. 21 8157 Elbert T. 1841488 Enjuto M. 141135 Fabre S. 4291106 Dziewanowska K. 3571157 El-Dahmy S. 659133 Enna M. 6361124 Fabrias G. 1831349 1831353 el-Dahmy S. I. 5151206 Enomoto S. 4631107 1841466 3571187 188 189 190 El-Daly E. 4091306 Enriquez R. G. 159185 3581199 200 Elde R. 4091334 Enrui R. 5211687 Facchini P. J. 371124 25 E Elder H. V. 5211680 Entzeroth M. 296156 Facke T. 383113 Eldoksch H. A. 659144 Enwall C. E. L. 2991291 Fadnavis N. W. 1821322 Eache P. I. 3851189 Eldredge G. S. 2991262 Epperson J. R. 411161 Fagart J. 3851146 Eagles J. 9811 75 176 177 El-Ela M. A. 1621311 Erazo G.S. 635168 Fahlstadius P. 1821259 1831336 Earl A. J. 3321165 168 372171 Elenkov I. 5191486 Erdelmeier C. A. J. 731140 5 171348 1861684 1891903 Earl J. M. 3331206 el-Fatah H. 5151206 5221798 Faini F. 602197 6791243 Eary C. T. 1851541 El-Feraly F. S. 255166 Erdemgil F. Z. 5151144 Fairchild C. A. 2571184 189 Easton C. J. 1821298 218174 El-Fizga N. K. 1851607 Erdman T. R. 2991253 296160 3011465 Eastwood P. R. 1601171 3001400 Elgamal M. 82157 Eremin S. V. 4751104 Faitg T. 6511116 Ebata M. 651193 Elgamal M. H. E. 6781195 6791236 Erfle J. D. 356172 Fajardo V. 406161 Ebata T. 5 13116 5201636 El-Gammal M. 406154 Ergan F. 1851596 1891908 659128 Fakunaga N. 356119 Ebbesen P. 71124 Elgar M. A, 96129 Erickson K. L. 2971131 142 Falbe J. 180191 Ebeling A. 356155 El Hafa H.3841104 2981191 Falch B. S. 4281104 Eberly L. 4521183 El-Hamdy A. H. 1851607 Erickson M. C. 1881819 Falck J. R. 1811233 462114 Ebert-Khosla S. 55314 554125 26 Elias R. 1611271 Ericksonn K. L. 159186 Faleev N. G. 218126 27 28 29 32 Eliason R. 474138 Ericson L. 97159 Falgueyret J. P. 71/46 1821293 Ebisawa Y. 3001394 el-Idrissi M. 5181449 Ericsson J. 142175 90 6031110 Falick A. M. 82169 Eceizabarrena C. C. 650114 Eliseeva L. M. 405133 Eriksson U. 1441241 Falkenberg D. 61713 Echavarren A. M. 39172 Elisseou M. E. 1841481 Eris C. 255168 Falkenhagen H. 371147 Echeverri F. 981178 186 188 El-Jack M. 6031139 Erkel G. 159141 5201582 Fall R. 142152 53 60114 Eckardt K. 555155 El Jamili H. 1601142 Ermayanti T. M. 39123 Fall R. R. 241143 356163 Eckert J. W. 981200 5171369 El-Jissry M.A, 82146 Ermin N. 5151198 200 Famiglini G. 474111 Eckhardt G. 82125 30 34 57 73 el-Kashouy E. A, 5171366 Emst A. 428173 Fan D. 255137 74 Elkihel L. 3851182 Ernst B. P. 731205 Fan P. 1601140 Ecklund P.R. 241127 Elkin R. G. 97164 Ernst L. 659146 Fang D. F. 2561125 Ecroyd C. E. 971127 El-Komos M. E. 4091287 Ernster L. 60116 Fang H. 5151145 Eda S. 4511167 El-Lakany A. M. 2561106 Emst-Fonberg M. L. 3571140 Fang J. M. 72198 1611209 256185 Edberg S. 40517 Ellenberger S. R. 1421112 Erra F. 463156 86 102 5181422 659116 17 18 Ede R. M. 428181 Ellestad G. A. 109162 4641113 Ertan M. 5181437 6791220 Edgar J. 660149 Elliger C. A. 98/197 Esaki N. 219197 Fang L. 141130 Editorial 110lIIO Elliot K. 4101405 Escoubas P. 721124 971101 255146 Fang Q. C. 2571160 162 167 Edstrom E.D. 65019 Elliott J. M. 1851601 2561115 Fang S. D. 256192 Edwards C. M. 109191 Ellman J. A, 218133 Escribano F. C. 109151 Fang S. Y. 6791230 Edwards E. 981147 El-Maghraby M. A. 514191 Eskala P. 109148 49 50 Fang W. S. 2571160 Edwards J. 3331197 228 Elmaleh D. R. 1841461 Espaillat J. R. 5151180 Fang X. 677171 Edwards J. M. 40194 635164 El’man A. R. 5181400 Espinar L. A. 1601190 5151157 Fang X. H. 6781135 Edwards M. I. 721119 el-Mansour A. 5161301 5161228 240 Fang Z. 5201613 6781136 Edwards M. W.. 651175 El Marini A. 3321175 Espinoza B. G. C. 731141 Fanwick P. E. 384185 677171 72 Edwards 0. E. 6511119 Elmer J. S. 10179 Esposito B. F. 4101379 Fargeas V. 6361101 Edwards P. A, 142165 6031110 el-Missiry M. M. 5161250 Esquivel B. 255145 63 71 2561104 Farmer B.L. 383134 Edwards R. 981184 202 475183 el Modafar C. 981185 Es-Saady D. 255174 Farmer B. T. 462112 5561185 Elmore S. W. 5201600 Essar D. W. 4521183 Farmer S. W. 981165 Edwards R. L. 1821239 240 El-Olemy M. M. 401102 Egan L. A. 3331218 22 225 229 El-Razek M. H. A. 1621303 Essenberg M. 1431162 1591121 Farmer T. 331157 3321130 131 1601122 Farnsworth A. R. 405135 372169 73 El-Saadawi W. E. 1811164 Estaban J. L. 5151157 175 5161226 Farnsworth N. A, 255122 Egashira M. 428183 Esteban M. D. 971145 Farnsworth N. R. 72166 40711 78 Egerton J. R. 109149 50 El Sayed K. A. 203144 Estell R. E. 5151153 Farouz-Grant F. 4081247 Eggerer H. 141147 602130 31 59 El-Sebakhy N. 676131 Estevez J. C. 4081211 Farrag H. A. 4751112 Eggermont K. 981169 Elsey K. D.5171367 Faruk E. A. 3321147 Eggers S. H. 20142 el-Shahed F. A. 5161250 Estevez R. J. 4081211 Faskhutdinov M. F.. 405123 31 Eggert J. H. 451191 92 El-Shanawani M. A. 731148 Estevez V. A. 109161 406160 Eggleston D. S. 741229 El-Shazly A. 635177 659133 37 Estevez-Braun A, 72176 86 90 Fasth K.-J. 218158 59 Eglington A. J. 330138 41 Elson S. 331149 82 129 Fastrez J. 3321127 Eglinton G. 240110 67619 Elson S. W. 331170 71 3321143 Estevez-Reyes R. 72176 86 90 129 Fathi-Afshar R. 2991296 297 Egner R. 3571146 144 145 146 147 151 162 163 Estrella A. 159158 Fatica M. G. 1851611 Eguchi T. 218172 166 I73 178 179 193 196 Esumi Y.,981194 Fatima K. 589161 Ehler D. S. 2 19/96 122 3331197 198 200 209 212 215 Etherington T. 45211 77 Fattorusso E. 296181 96 2971138 Index of authors cited 1-57 139 140 2981201 228 234 235 Ferreira N.P. 602178 246 2991293 307 319 Ferrer A. 141132 43 Faucher D. 372191 Ferrero B. 4081204 Fauchet V. 5161292 Fem P. H. 72165 731146 Faul M. M. 4291108 Fesik S. W. 219195 Faulkner D. J. 158125 27 1591120 Fett D. 3581191 2581235 29611 2 3 4 5 6 7 8 Feyerbend C.,4101407 9 10 11 12 33 2971141 144 Fiala R. R. 5551110 2981207 211 225 2991267 277 Fiallega G. 1601186 303 3001414 415 3011467 468 Fianese V. 5191527 4281105 4641111 65014 Fiaschi R. 384188 92 93 94 Faure R. 1611212 271 5221792 Fid F. 5151206 6791234 Fiedler K. 96119 Fava A. 659112 Field J. S. 741245 Favre-Bonvin J. 5141137 Field R. A. 2191114 3321188 Fawcett T. 3571169 Field S. J. 2191106 107 Fay L. 1871754 Fielding L.38319 Fayed A. H. H. 4091338 Fields A. 4101425 Fazio C. 1601195 255165 67 70 Fiet J. 3851143 Fazylov S. D. 401148 635192 Fiez-Vandal P. Y. 4101397 Feairheller S. H. 1881829 Figueiredo A. C. 5151195 Fedeli W. 450175 Figueiredo M. R. 25512 Federavo T. A, 9611 7 Figueras F. 5181416 Federici E. 1611230 6781194 Figueredo A. C. 5141101 Fedoreyev S. A. 4641110 Filer C. W. 331162 98 Fedorov P. I. 5191517 Filho A. A. 82140 Fedrizzi G. 38511 74 Filho A. W. 5151178 Feeny P. 96116 971112 117 Filho H. C. A. 721110 Feghih R. 109191 Filho R. B. 731143 Fehlhaber H.-W. 82159 1101102 Filho U. F. L. 721110 105 106 107 Filho W. W. 72181 Fehling E. 1871784 Filiatrault M. J. 2981240 Fehr C. 5211696 700 Filippich L. J. 97167 Fehrenbach F. J. 1881858 Filippini R.47414 Fei X. S. 635156 Findlay J. A. 463173 Feinendegen L. E. 1841490 Finer J. 2991253 Feito I. 158133 Fingola F. F. 514171 Felici A. 3321128 Fink A. L. 3321136 Felicio J. D. 5221807 Finkelstein M. 428166 Feliz M. 2981197 Finkelstein R. R. 1431193 Felklova M. 513139 Finn M. F. 331189 Fellows L. E. 635122 36 Finn M. J. 331197 Felton G. W. 97181 82 Finn R. D. 41 11446 Feltrauer J. 406178 Finnegan I. M. 4081273 Feneau-Dupont J. 660156 Fiorentino A. 158118 6771110 Fenet B. 1821295 Firdous A. J. 4071181 Feng Q. C. 4071154 Firdous S. 4061101 6781125 Feng R. 203132 Firestone D. 1861685 Feng W. 20215 Firestone R. A. 3851183 Feng Z. 1431182 Firl J. 1851550 Fenical W. 1lOlI10 296127 297198 Firman K. 475161 104 106 3001334 340 362 375 Fischer H.D. 971144 301I43 7 445 46216 8 10 I9 Fischer N. H. 971141. 143 144 Fennen J. 5221814 1431175 159170 1601202 1621310 Fenwick A. E. 1831361 316 256188 2571224 514169 Feringa B. L. 71135 721117 Fischer-Lui I. 297186 5 181409 520161 9 Fish W. R. 3571124 Fernandez B. 158133 Fisher J. 331159 3321137 Fernandez-Caiion J. M. 372179 Fisher J. F. 3851179 Fernadez-Martin F. 1851609 Fisher M. H. 109145 48 49 50 52 Fernandes A. M. A. P. 72/65 Fisher N. S. 463172 Fernandes J. 677181 Fishkin M. D. 4101422 Fernandes J. B. 731164 61719 Fishman A. 1821277 Fernandes L. 3001338 Fitch D. M. 428182 Fernandez I. 731153 Fitjer L. 1601150 152 Fernandez I. I621300 Fitz L. D. 40515 Fernandez J. 5561146 152 Fitz W. 1871787 Fernandez J. A. 589169 70 Fitzi R.218152 57 Fernandez J. B. 15812 Fitzpatrick K. 40516 Fernandez J. M. 303120 63517 Fitzsimmons B. 1801125 Fernandez L. 1621344 Fitzsimons B. C. 1431152 Fernandez L. I. 4071190 Fkyerat A, 2571187 Fernandez R. 2981197 Flamini G. 5 161233 5221774 Fernandez-Guasti A. 4101409 Flanagan D. M. 82163 64 68 Fernandez-Martin R. 1441259 Flatau S. 303112 13 Fernandez Mateos A, 3841116 Flath R. A, 96137 Fernandez-Moreno M. A. 554146 Flavin M. T. 475172 Fernez F. 5181407 Fleet G. W. J. 450123 6511112 Fernez-Matellano L. 5221792 Fleischer A, 514182 Feron G. 142157 Fleischer Z. 514182 Ferraina R. A, 1851574 Flemming S. 384172 5171322 Ferrari E. 4081205 5 181462 Ferrari P. 159145 Fletcher S. R. 650132 39 Ferrari P. 428191 Fletouris D. J.1851519 Ferraz H. M. C. 5181447 467 Fletton R. A, 331172 383112 Ferreira A. G. 15812 Fleurant A. 39168 635157 Ferreira D. 741264 Fleuriet A. 981185 Ferreira J. F. S. 1601133 134 Flint D. H. 3581243 246 Ferreira M. J. U. 677165 Flippen-Anderson J. L. 911 1-58 Natural Product Reports 1997 Flood J. 981179 Florentin D. 3581247 Flores E. 255163 Flores H. E. 3571183 371116 Flores M. 2561104 Floss H. G. 1441253 3561102 3571103 104 371113 33 44914 450122 24 25 26 27 28 29 30 32 33 50 51 61 69 70 72 45 11106 110 115 116. I17 123 127 129 130 133 134 135 136 138 151 155 156,157 160 173 4521180 192 194 462118 553112 13 14 15 555147 5561133 6031103 Floyd D. M. 331153 Fludzinski P. I621330 Flygare J. A. 513111 Flynn E. H.109182 83 Flynn G.A. 3851139 Fochem H. 180191 Focke M. 3571138 156 Foddai S. 5211717 5221752 Foderaro T. A. 2991262 Foglia T. A. 1861642 813 829 832 833 Foglio M. H. 1441237 238 Fojtik J. P. 3021495 3851169 Foldes F. F. 406143 Foldesiova V. 158120 Foley W. J. 96149 Fonck E. 372150 Fondekar K. P. 4751119 Fong H. H. S. 731140 6791205 Font J. 2971122 513115 Font L. M. 5201621 Fontana A. 3001408 Fontana G. A, 4101380 Font-Bardia M. 589172 Fontina S. S. 5141101 Foor F. 5551108 Forche E. 617120 Fordos J. 4511164 Forenza S. 109169 5561129 Forgo P. 383110 Formelli F. 109/24 25 Forns P. 589172 86 Forrest A. K. 372177 Forrest Jr. J. N. 3011493 Forskov T. 1881809 Forster P. I. 5141106 107 121 5151182 Forsyth C.J. 159169 1621354 30 1143 7 Fortes A. G. 5191535 Fortunak J. D. 5901130 131 Forzy L. 1811158 Fosberry A. P. 3321168 372171 Foster G. 5561174 Foster L. M. 71132 158122 Fotsis T. 71117 18 41 Fouraste I. 20114 677190 Fourie P. C. 1861680 Fournet A. 20124 405130 514194 6 18/31 Fournier F. 383115 Fournier G. 5 161257 Foutoullakis M. 6031103 Fox A. W. 4101379 Fox B. G. 3571172 3581236 Fox C. 371133 Fox D. N. A. 40185 Fox K. M. 3571112 450127 33 34 Frades J. M. 5191505 506 507 Fraga B. M. 1611221 2561128 475196 Frahm A. W. 30317 Fraile A. G. 5201580 5211669 Fraile J. M. 5181416 Fraioli S. 405110 Fraisse D. J. 5151151 Franchi G. 109124 Francis M. J. 6031119 Francis T. A. 1841446 3011467 Francisco C.2971102 3011447 456 Francke W. 39164 96138 39 Francois I. 741229 FranCois I. 330110 Franich R. A. 971127 Frank B. L. 109155 64 Frankel E. N. 180188 1841494 510 544 545 546 1871805 Franki N. 4091319 Franklin A. S. 635142 Frankshun R. A. 109152 Franssen M. C. R. 1601177 178 Fransson B. 217112 13 38 Franzblau S. G. 256188 Franzyk H. 1421116 123 124 125 126 5211719 5221753 788 Frappier F. 3581247 589157 Fratini A. V. 383134 Frechette Y. 159182 Fredenhagen A. 4281102 4291121 Frederiksen L. B. 1421117 5211721 5221797 Frederiksen S. M. 650128 Fredrickson E. L. 5151153 Freedman T. B. 40513. 4 Freeman J. W. 6031132 Freer I. 602139 40 57 Freiberg L. 109191 Freire de Carvaiho L. D. A. 203124 Freire R.3851191 Freitag R. 1881839 Freitas J. C. B. R. 514171 Frelek J. 383119 French E. C. 5151180 French L. G. 5191555 French S. J. 356123 51 Frennesson D. B. 4291113 Frenzel T. 371133 Frere J.-H. 3321128 Frere J.-M. 330128 29 Fresneda P. M. 3011458 Frey D. 4081215 Frey P. A. 356160 Freyer A. J. 2981207 4061101 40711 83 Frias I. 72/49 Fricke C. 1601147 Friedrich D. 651195 96 Fngerio M. 38511 74 Frignoli R. 39117 635111 Friis P. 971125 Frimpong K. 141126 41 42 Fritea M. 401124 Fritsch N. 2971106 Frobel K. 4511144 Frode R. 650112 6791244 Froehlich R. 5201659 Froemming K. 475149 Froestl W. 406178 Froetschel M. A. 3916 9 63516 Frohberg L. 82159 Frohlich R. 401152 Frolow F. 3011452 650110 Fromm M.F. 4101399 Frommer W. 4511147 Fronczek F. R. 971144 1621310 2571224 Froschauer G. 4081239 Frost J. W. 4511120 Fruchier A, 255118 Frydman V. M. 24211 79 Frye L. L. 3021495 3851169 Fryhle C. 4511123 Fu H. 55314 554127 32 Fu J. 6781128 Fu S. 5191513 Fu X. 255137 2981241 3001384 Fu Y. F. 406139 Fuchikami Y. 5171363 Fuchino H. 677160 Fuchs P. L. 3011471 3851210 211 212 213 214 Fuchs P. N. 4081267 Fuchsbichler S. 356155 Fuente M. C. de la 4061103 Fuentes E. R. 255119 Fuerst J. 5181399 Fuerst Z. 4081240 Fuhrer H. 384178 81 451194 Fuhrhop J. H. 1801141 Fuji K. 2571156 428170 Fujihara Y. 514168 74 5171378 379 5211661 662 Fujii A, 731207 428140 5201634 Furukawa H. 20153 54 55 56 Gan X.-H.71126 14 3571116 127 128 5561138 200 201 Fujii K. 741253 42719 475164 I17 61 8/69 70 72 Gancher S. T. 4081207 Garthwaite I. 428181 Gand E. 1591107 Fujii T. 1851530 2991297 3851197 73 75 81 5211730 Furukawa J. 3571148 450165 Gandier S. 4071203 Garwin J. L. 356143 Fujikoto Y. 3851193 Furukawa K. 5 161244 Ganem B. 4521186 Gary-Bobo C. M. 1101100 Fujimaki K. 296168 463139 Furukawa M. 677194 Gang D. R. 96148 Garzon M. J. 33211 75 Fujimori K. 218182 Furukawa N. 5 181405 Gangadhar A. 1831345 Gaset A. 180198 Fujimori T. 1441249 1821257 Furukawa Y. 296126 1841508 1861674 GaSiC O. 635166 Fujimoto H. 427111 5561179 181 Furumai T. 555161 62 63 64 65. Gangan V. D. 255159 Gaskin J. F. 971142 Fujimoto K. 1821313 1841515 66 Gange D. 109166 Gaskin P.1431215 221 226 231 240113 241158 59 60 76 88 91, 296126 Furuno T. 1601149 256183 Gangul S. 1831424 Ganguli B. N. I821276 94 103 2421105 112 113 122 Fujimoto T. 72191 Furuta H. 1621291 Ganguli S. 3571126 38511 76 127 128 129 130 135 146 152, Fujimoto. Y. 9146 1881848 255152 Furuta T. 2191120 5181421 2991301 302 6771100 6781200 Furuya K. 296137 463190 93 97 Gani D. 218130 31 3321160 153 154 159 161 162 164 176 Fujioka S. 1016 18 52 53 54 55 100 Gant T. G. 159184 179 2431194 198 202 2561114 85 86 87 89 90 93 94 2421128 Furuya M. 2421163 166 Gantier J. C. 20124 618131 139 141 142 152 153 Furuya T. 14311 78 1591113 Ganz I. 5181412 Gasparri M. G. 5211680 Fujioka T. 4081237 677170 5 171339 5 181414 5 191560 561 Ganper D. 1601173 Gassen M. 1841513 Gao B.5151211 Gassmann G. 296185 Fujisaka K. 1441217 5211668 676130 Fujisaki S. 602142 Fuse T. 20123 35711 76 Gao C.-Y. 427124 Gasson B. C.,331199 3321161 Fujisawa A. 5171321 Fusitani N. 1841453 203136 37 38 Gao H. 384167 Gastaldo L. 428191 Fujisawa T. 218182 2581241 2971137 Gao J. 5221779 780 Gatch M. B. 4091348 4101415 Gao J.-H. 6781143 6791230 Gatilov Y. V. 1591109 299 322 Fujishima Y. 3321193 3331224 2981183 184 199 200 244 6781188 2991280 3011469 470 463127 Gao M. 741252 6781160 2571200 Fujisuka H. 513113 Futatsuishi Y. 2561127 Gao P. 4081234 Gauglitz Jr. E. J. 1861648 649 Gaul K. L. 660149 Fujita A, 1611274 4631101 Futatsuya F. 101104 Gao Q. 25711 73 Fujita H. 5171325 Fyge A, 4091304 Gao X. 109140 74 75 Gaur S. 5201631 Fujita M. 1431168 1601124 3011472 Gao X.F. 676121 Gavagnin M. 2971154 3001408 413 Fujita S. 677156 57 Gao Y. 6511110 Gavazzi G. 5561196 Fujita T. 255125 2561120 124 G Gao Y. G. 109119 20 Gavifio R. 659121 383118 513135 5161265 5171344 Gaoxiong R. 474147 Gavilanes J. G. 3571184 5221757 789 Garay M. 2981242 Gavin J. A. 202111 Fujiwara H. 513137 Ga N. 635179 Garbarino J. A, 1611230 2561135 Gavino R. 1611211 Fujiwara K. 2971116 117 Gabetta B. 2561151 2571152 163 87 Gavrilyuk 0.A. 514177 Garbe W. 3581191 Gawdzik J. 474119 Fukami H. 96116 971106 660147 5211687 Garcia-Granados A. 1611260 Gawley R. E. 296170 463140 Fukamiya N. 4751117 677192 93 Gable R. W. 405127 95 Gaboury. J. A. 731138 154 Garcai J. I. 5181416 Gaydou E. M. 1811176 197 216 Fukata F. 46219 Gacs-Baitz E. 6791243 Garcez W.405137 1871713 5151158 Fukazawa Y. 3001365 Gadski R. A. 3851189 Garcia A, 4061100 102 Gazaliev A. M. 401146 147 148 635192 93 94 95 Fukuchi I. 5181441 Gaefvert E. 256184 Garcia B. 731153 Fukuda N. 255161 Gaffield W. 203125 53 Garcia B. 1611240 243 Ge. X. 406168 Fukuda T. 1441249 Gaffney T. 372163 4521184 Garcia C. L. 1611240 Ge Y. T. 5211740 Garcia E. 406144 Gebler J. C. 371137 3851175 Fukui H. 241173 5181430 Gafni M. 4101425 Fukui M. 463142 Gage D. A. 1441225 2421121 123 Garcia F. M. 4071199 Gedde-Dahl A. 1831419 Fukui N. 428135 139 159 256194 5151220 5161247 Garcia H. S. 1871790 Gedris T. E. 255175 Garcia J. I. 5181427 Geethanjali Y. 4751110 Fukui Y. 9162 6771121 Fukumoto K. 159193 94 1621353 Gagnon H. 5151141 Garcia M. A. 5211669 Geewananda Y.A. 20159 3001341 428183 61 8141 Gaiday N. V. 1811174 Garcia M-E. 55611 70 Geib S. J. 5181431 Fukunaga Y. 4101370 Gaillard E. 2015 Garcia M. L. 1591101 Geiger A. 4511169 I70 Fukuoka M. 218128 Gainsford G. J. 635135 Garcia M. M. 4091346 Geiger H. 475190 91 Fukushi E. 1611265 Galagovsky L. R. 384152 Garcia M. R. 5221752 635168 Geiser F. O. 1861656 Fukushi Y. 981183 I611224 Galambosi B. 5 151160 Garcia P. 383115 Geissler H. 5221814 Fukushima C.. 721101 Galand N. 401120 Garcia P. A. 71/23 Geissman T. A. 24211 77 Fukuyama K.. 5561181 Galeffi C. 741274 1611230 589153 Garcia Y. I611260 Geiwiz J. 2561110 Fukuyama. T. 589152 6781194 Garcia-Garcia F. 981188 Gekker G. 4091322 Fukuyama Y . 15911I1 Galfre A, 5211694 Garcia-Granados A, 255133 34 35 Gelbard A. S.217115 Fukuyo E. 554122 Galindo J. 5211696 700 2561130 Gelbaum J. A. 659139 Fukuzawa K. 1851530 Galizzi A. 555183 Garcia-Gravalos M. D. 71121 22 Gelbaum L. T. 659138 677177 78 Fukuzawa S. 203136 37 38 Gallagher D. J. 6361103 104 109 23 Gelin M. 3851182 1851535 537. 3011426 469 470 Gallagher M. D. S. 981181 Garcia-Jacas N. 72179 Gellerstadt G. 741242 Full G. 5211705 Gallagher P. F. 660149 Garcia-Lliso V. 72179 Genazzini A. D. 4101413 Fullas F. 6791205 Gallagher T. 40185 63414 651166 Garcia-Martinez J. L. 2561141 Genazzini A. R. 4101413 'Fuller R. W. 475170 71 Gallant M. 4281101 Fulmor W. 450183 Gallardo F. 41 11455 Garcia-Rojas C. M. C. 2561121 Geng Z. 5181410 Fulop V. 2431190 Galle A. M. 1871785 Garcia-Rubio S. 589160 Gennari C. 5181418 5191548 Fiilop V.3321189 372174 Galleni H. 3321128 Garcia-Zafra S. 3011458 Genova E. M. 5 151161 Fulston M. 3321173 3331197 200 Gallexot P. 5181397 Garci-Vallejo M. C. 51511 79 Gentile F. 4291129 Gardea-Torresdey J. L. 5 151153 Gentile L. N. 5201598 Fulton D. C. 6031135 137 Galligan J. J. 4101401 Fumero B. 4071193 Gallo G. G. 450185 Gardner H. W. 981201 1801143 Georg G. I. 2571175 176 179 180 Funabashi H. 3571148 Gallo M. 676142 1851564 186 192 Funabashi T. 3861228 Gallon A. A, I871774 Garg H. S. 255110 2971136 Georgieva A. 29711 14 Funada M. 4091293 Gallon J. R. 6511121 2991281 Georgieva T. 5 191486 Funada T. 1871798 799 1881860 Gally H. U. 356137 Garg P. 4091319 Georgopapadakou N. H. 331153 Funayama S. 449111 12 450113 14 Galonnier R. 1811197 Garg S. N. 5141112 Geraci L.S. 589163 4511167 617110 618177 78 Galons H. 3851143 Gariboldi P. 82/20 2571152 163 Geralds R. S. 296145 Fung S. Y. 60118 9 Galt R. H. B. 240116 241117 18 164 676131 Gerard H. C. 1811221 1821306 Funk C. l421111 1431209 210 20 52 53 72 2421184 Garlaschelli L. 5 161291 67611 7 Gerhardt B. 1801134 5 191562 Galushko S. V. 218179 Garneau F. X. 2571155 5 151141 Gerke R. 1601150 Fuqua W. C.. 462123 Galvagno S. 5 161300 Garner A. C. 5171342 Gerlach H. 296151 Galvan A, 4101378 404 Garner C. M. 5181439 Germain G. 5191532 Furamai T. 555160 Galvan M. F. 475196 Garner P. 5201640 Furber M. 2421164 166 167 168 Galvez J. A. 5201635 German E. 4091341 2561145 Galzy P. 1881812 Garofalo L. M. 3861220 German J. B. 1861699 1881868 Furihata K.. 42717 44917 8 9 Gambacorta A. 180193 1811207 Garraffo H.M. 20133 34. 651175 1891898 45 11168 5 551104 450156 60 63 Garreau R. 384195 Gershenzon J. 14112 1421130 Furneaux R. H. 39146 635135 Gamble w. R. 6791239 Garrido J. L. 1871747 5 13/41 43 45 60211 6 Furstner A, 2981217 Games D. E. I861653 Garrido M. 1611284 Gerst N. 3851188 Fiirstner A. 20121. 428173 Gamilov Y. V. 1611235 Garrido N. M. 159160 255116 Gerth K. 4521187 5561149 617120 Furstoss R. 5161279 Gamoh K. 9116 24 47 57 63 Garry R. P. 5151208 Gerwick W. H. 1811169 212 232 Furu P. 67811 92 Gan T. 589145 102 Garson M. J. 1841451 452 296113 235 237 1821242. 243 255 258 Index of authors cited 1-59 1891887 897 296143 44 45 47 48 52 53 79 2971104 106 111 113 3571118 123 132 133 135 136 3581203 462112 13 463165 81 5561140 145 Gerzon K.109182 Gessan J. P. 5181471 Gesser H. D. 1801131 Gewain K. M. 450121 5551106 107 108 109 Gfeller H. 96113 Gharbi-Benarous J. 109194 95 Gharpure M. M. 2571178 Ghazali H. M. 1881815 Ghedira K. 82126 47 Ghiara C. 71114 15 Ghini A. A. 3851141 Ghisalba O. 450186 451193 94 95 98 Ghoneim M. 41 11451 Ghosal M. 1601146 Ghosh A, 1811184 Ghosh A. C. 5141129 Ghosh L. 39114 63519 Ghosh R. K. 2561118 Ghosh S. 513112 Ghoshdastidar P. P. 618166 Ghuman M. A, 588110 Giacchino J. L. 4091333 Giacobbe R. A, 1591101 Giacomelli G. 5191551 Giacomello G. 450175 Giacopello S. 3851181 Giamalva D. H. 1851532 Gianetto P. 5201633 Gianfagna T. 2421140 Giangrandi C. 4081204 Giannellini V. 71114 Giannini J.L. 1611286 Gibbons N. 4091319 Gibbons P. H. 450121 5551106 108 Gibbons S. 2013 Giberti G. C. 6791229 Gibson K. H. 1811238 Gibson K. J. 35711 79 Gibson R. 218176 2191122 Gibson S. 3571176 Gibson S. P. 5551112 Gieb S. J. 5201647 Giessrnan T. A, 241155 Giez I. 96119 97161 Gigante B. 256182 Gijsen H. J. 1621332 Gijsen H. J. M. 1431194 Gijzen M. 514163 Gil G. 5211660 Gil J. A. 5551114 Gil R. R. 72182 83 2571216 Gilani A. 203134 Gilbert E. J. 4291116 Gilbert J. 1431153 154 Gilfoyle D. J. 219194 Gilkison I. S. 1851593 Gill S. 401127 Gillan F. T. 1811193 Gillard J. W. 71146 Gillett J. 331170 71 3321151 162 163 Gillum A. M. 3331204 618155 59 Gilrnore C. J. 450179 Gilmore J. 721119 Gilrnour S.J. 241190 2421119 127 146 Gilpin M. L. 331195 101 102 103 Gil-Turnes M. S. 462119 Gimbert Y. 2571187 Gimenez A, 159141 Giner J-L. 5561127 676122 Giordan M. 660154 Giordano A. 2991322 3851209 Giordano F. 384144 Giorgi M. 1601142 Giori A. 5161289 Giovannini R. 635110 Girard A. E. 3311105 Girard C. 5201645 Girard Y. 71/46 Giraud R. 4081256 Girault J.-P. 109195 3851204 Girault P. J. 109194 Girg M. 1101106 Gitlesen T. 1881863 Giudicianni I. 1871730 Giuffro S. E. 5221752 Giuliani F. 109125 Gladu P. K. 463174 Glasi S. 1611259 162/309 Glasl S. 5171328 Glaude. R. P. 109186 Gleason W. B. 4081247 Gleba Y. 58814 Gledhill L. 1431153 Gleizes M. 1431135 Glendenning L. 463177 Gleye J. 20114 677190 Glinski J.A. 659139 Glitho A. I. 5151141 Gloer J. B. 42712b 463189 92 98 4641108 6791239 Glombitza K.-W. 2971108 109 Glover V. 4091303 Glushenkova A. I. 1821262 263 Gmeiner P. 3914 5 Gnabre J. 71145 Gnecco D. 159185 Goad L. J. 101103 Goasdoue N. 1861695 Godard A. 3011459 427127 28 29 6 50156 5 7 Godbole H. M. 474133 475157 Godchaux 111 W. 356120 Goddard R. 5191530 5201582 Godde A. 218122 Goderis I. 981168 Godtfredsen W. O. 3311108 Goegelman R. T. 330134 43 46 Goeren N. 1621315 Goerger M. M. 1841480 Goetz M. 5201586 Goff D. 81/11 18 Gogonea C. 1601151 Goh K.-C. 3331223 224 Goh S. H. 1881821 Goins K. 159149 1601140 2991260 Goiny M. 4091353 Goldberg I. 2571222 2991313 30013 77 30 11452 650110 6791241 Goldberg I.H. 109173 74 75 5 5611 2 7 Goldfine H. 356153 I01 Goldin B. R. 71141 Golding B. T. 1821314 Coldman A, 3331199 Goldmann A. 6511111 Goldsack Ci. 5141133 Goldsack R. J. 514183 92 96 106 107 121 133 5151142 182 197 Goldstein B. P. 428191 Golebiewski W. M. 3851178 Golebiowski A, 39144 Golik J. 109155 64 69 71 110l109 25711 73 296172 428193 5561129 Golobov M. 3321128 Golz A, 3571156 Gornes E. C. 5151178 Gomes E. T. 20114 Gomez A, 255150 51 Gomez A, 159158 Gornez Arrayas R. 635132 Gornez D. D. P. M. 159160 Gomez-Barrios M. L. 14311 75 1621316 Gomez-Perez B. 159160 G6mez-Pardo E. 372180 Gomez M. 1101104 Gomez M. A. 475195 Gomez-Laurito J. 405136 Gomez-Paloma L. 109168 Gomi K.421123 4291123 125 Gomulka M. 1601197 Goncalves L. A. G. 1851576 Gondol D. 1601185 Gong F. 372163 4521184 Gong G. 5 191545 Gong Q. 4101391 Gonzalez A. G. 72176 86 90 129 160 159152 1601180 5211684 58819 11 617121 6791209 210 Gonzalez C. 2571204 3001353 Gonzalez E. 2571204 3001353 Gonzalez F. 5161270 Gonzalez J. 1881807 Gonzalez M. 4101388 Gonzalez M. D. 650114 Gonzalez P. 2561128 Gonzalez R. R. 5211699 Gonzalez-Coloma A. 721124 16011 53 Gonzalez-Moreno A, 4071195 Gonzalez-Perez J. A. 731129 Gonzalez Sierra M. 81112 16 56 Good L. A. 635131 Goodacre J. 331187 88 Goodman H. M. 241145 2421124 Goodman J. M. 5191548 5561201 Goodman J. P. 96151 Goodman M. M. I841460 Goodridge A. G. 3581210 Goodwin T.W. 463132 Goose C. 4101403 Goosey M. W. 141129 Gopal R. 5151185 Gopalakrishnan G. 97195 Gopichand Y. 2991291 3001395 Gora J. 5151221 5161235 Goralski C. T. 5191550 Gorbach S. L. 71141 Gorbacheva L. A. 6791203 Gordaliza M. 7117 21 22 23 88 188 291 1601174 255147 Gordiano F. 2971123 Gordon J. A, 1801128 Gordon M. M. 659138 Gore J. 5 181413 Gore M. P. 4511158 555158 Gore P. M. 10816 Goren N. 1601187 1611227 Gorharn P. R. 6511119 Gorio A, 4091324 341 Gorlach J. 602149 Gorline S. H. 981156 Gorman M. 33011 7 Gorner T. 1861658 Gornicki P. 356165 Gorovoi P. G. 406160 Gorrison H. 218177 Gorst-Allman C. P. 1821274 553115 Gortz H.-D. 4641119 Gorun V. 217116 Gorunovic M. S. 5151208 Gosalbo L.1831349 353 3571188 189 190 Gosavi K. 2971135 Gosling P. A, 5161293 Gosmann G. 6791232 Gosney I. 5201631 Goss P. E. 635126 Gosse-Kobo B. 1821327 Goswami A. 5171340 Goswami K. N. 475148 618161 Goti A, 39115 17 635111 12 13 14 Goto H. 1601151 Goto J. 384198 Goto M. 450140 5171359 Goto T. 1861662 663 296158 45013 7 38 39 5 551100 Gotoh M. 71134 77 Gotor V. 1871801 Gottlieb H. E. 981196 15812 Gottlieb 0.R. 12187 93 131147 741236 265 15812 1611233 25512 Gottstein W. J. 3311113 Gotz P. H. 589166 Goudie A. C. 5551112 Goulart M. 0.F. 1611229 Gould A. E. 450114 Gould R. O. 2561100 Gould S. J. 3331213 372187 88 45 11150 158 159 160 162 555151 52 53 56 58 Goulding T. 5891116 Gourlay G. K. 4081281 Gournelis D.82135 36 Goux W. J. 2191105 Govindachari T. R. 97195 677167 Govindan G. 2571205 Govindan G. H. 3001354 Govindan M. 2571205 2981241 3001354 Gowan E. 96150 Goyal S. 741256 Gozler B. 741228 Gozler B. 61717 Gozler R. 12178 Gozler T. 72178 741228 303110 I1 Gozler T. 61717 Grabarczyk H. 1601181 197 I611205 Grabber J. H. 72162 Grabias B. 5221768 Grabley S. 651168 Grabowska M. 475180 Grabowski E. J. J. 3841129 Grace K. J. S. 5221813 Gracia A, 2971122 Graebe J. E. 14111 1431211 1441222 224 226 232 233 24018 11 12 241126 30 33 50 58 59 63 65 67 68 70 77 82 87 88 89 90 93 94 95 96 97,98 99 100 101 2421106 108 110 118 120 122 2431189 Graenicher F.. 5221800 Graeve C. 6361100 Graham A.C. 109188 Graham R. G. 3311113 Grahm L. 3851178 Graille J. 1881806 811 812 861 Gramajo H. 554138 Grampovnik D. J. 25711 74 Grancai D. 158120 Grandclaudon P. 650116 Grandgirard A, 180197 1821296 I861613 Grant D. M. 1611276 589180 6771109 6781196 Grasdalen H. 1871729 731 732 Grau R. J. 180189 Grausem B. 141134 Gravalos D. G. 71136 731130 16011 94 29811 73 Gravalos M. D. G. 2991313 6791241 Gravier-Pelletier C. 180196 Gray A. I. 2013 4 1621333 255127 4081223 475166 92 514199 651161 6771105 Gray G. A, 20126 Gray G. N. 159186 2971131 6791206 Gray G. R. 356191 92 Gray J. C. 60211 7 Gray R. T. 356123 Gray S. M. 39165 Graydon W. F. 1841503 Grayer R. G. 981191 Grayer R. J. 971105 981159 Grayson D.H. 51311 2 Graziani E. I. 3001416 676147 Grazini M. V. A. 5181447 Grebnev B. B. 3011448 Greca M. D. 741230 Grechkin A. N. 1851561 Greco M. N. 2981185 Cree R. I821327 Green B. 555168 Green D. L. C. 39111 81 Green J. R. 2421164 Green R. 356139 Green R. H. 109143 5551105 Green S. P. 741225 Green T. R. 602196 Greene A. E. 2571187 Greene B. M. 109144 Greene H. L. 1841514 Greenspan A. D. 356156 Greenspan M. D. 356113 Greenwald R. B. 2571191 Greenwood S. L. 2191104 Greewald M. K. 4101435 Greger H. 617114 Gregor V. E. 618164 Gregory L. E. 10171 Grehan B. 1831352 Grehl M. 401152 153 1-60 Natural Product Reports 1997 Grehn L. 217110 11 12 13 Gueritte-Voegelein F. 2571172 177 Gussev C. 1601196 Hall D.G. 2561133 218/38 2 1911 10 Guerra D. J. 3571157 Gusta L. V. 10183 Hall J. G. 108115 5171356 Greibrokk T. 1801112 Guerra F. M. 1611257 Gustafson K. R. 159197 2971130 Hall P. de la M. 4081281 Greiner I. 589187 Guerrero A, 1831350 1841459 2991328 3011440 Hall R. M. 55611 72 173 Greinwald R. 401126 635169 73 35811 98 Gustafson K. V. 4091357 Hall T. W. 3311115 75 76 78 659140 Guerrero P. P. 2571198 3001345 Gustafson L. L. 4091304 Hallahan D. L. 1421113 114 134 Grenade H. R. 3021496 Guerriero A. 1811236 1821241 Gut S. 659114 Haller J. 401150 636199 Gri G. 555183 2571207 208 296182 2991271 Guthrie J. W. 1861656 Hallman M. 1841512 Gridnev Y. 4751107 3001369 370 463188 99 464/112 Gutierrez C. 1601153 Hallock Y. F. 2971153 Grieco P. A. 589198 677191 Guette J.P. 384195 Gutierrez E. 1611206 Halloin J. M. 981197. 1861698 Griego J. 218176 Gueugnot S. 1821301 Gutierrez M. C. 981184 Halls S. C.. 96148 Grierson D. S.. 588113 Guezennec J. 1871760 Gutierrez-Mellado M. C. 475183 Haltiwanger R. C.. 741229 4081213 Griese E. U. 4101399 Guggisberg A. 372167 Gutman A. L. 3321156 174 450179 Griesser U. J. 659130 Guilhem J. 65015 Gutowski J. A. 602132 61 Hama Y. 1851522 Griffin D. R. J. 331158 121 Guilhon G. M. 475155 Guurjar M. K. 405128 Hamabuchi S. 2981214 428167 Griffin J. F. 4081247 Guilhon G. M. P. 61712 Guv E. R. 4091295 Hamada H. 1601122. 5171363 Griffin J. P. 3331228 Guilhon G. M. S. P. 2019 Guvenc A. 5151219 Hamada M. 449110 450115 Griffin K. E. 33016 7 Guillaume D. 6781180 197 Guy A. 384195 4511172 5211722 5561135 Griffiths K.71116 6791229 232 Guy R. K. 2561148 150 2571183 Hamada T. 5211661 Griffiths P. G.. 9161 Guillerm G. 3581247 Guyot M. 3011460 427126 Hamada Y. 296134 3011441 Griffiths R. C. 6511112 Guillermo J. A, 5211684 Guyre P. M. 4091323 Hamagashira N. 635/24 Griggs D. L.. 2421116 Guillermo. R. 2561128 Guzman C. A. 5151157 175 179 Hamalainen E. K. 71141 Grillo T. A, 981188 Guillier F. 650156 57 5 161228 238 240 Hamann M. T. 159149 2991260 Grimaud J.. 1881811 Guillory J. K. 383122 Gygax. D. 451195 463162 Grimwade J.. 2981212 Guilloton M. 141125 Gynther J. 474113 Hamasaki T. 5561163 165 179 Grinenko. G. S.. 384145 Guimaraes A. M. 589197 Gyulai S. 4081238 180 181 Grinsteiner T. J. 203150 Guinaudeau H. 405135 5 14194 Hamberg M. 1801129 145 Grisebach H. 601111 Guindon.Y. 1801123 1831336 1851551 553 554 555 Grishkovets V. I. 6781156 167 168 Guirimand F. 4101434 H 563 567 568 1861684 1891887 183 6791203 Gujurata T. L. 5161278 888 896 3571132 133 135 136 Grivas K. 4081230 Gulacar F. O. 1811228 Hambley T. W. 4291130 Grochowicz L. K. 39153 Gulakowski R. J. 475170 71 Ha S. 450130 50 51 61 70 Hamburger M.. 5211747 Grochowicz P. M. 39152 53 Gulati K. 4091361 4511123 5551120 121 Hamed S. 41 11451 Grogan M. J. 5891123 Gulavita N. K. 2981242 Haak U. 96127 Hamel E. 2571188 384186 Groger D. 372160 61 618160 Gulden K.-P. 428195 Habeck T. 16011 72 4091298 Hamerski D. 6031138 Groger. S. 371133 4521191 Guldner A. 5211688 Haber A. 451190 555188 Hamidah S. 1881815 Gromova A. S. 6781185 Gulick P. J. 142163 64 84 Habermann A.K. 5201655 Hamill R. L. 33011 331183 Gronert B. J. 406150 Gullhn F. 428144 Habermehl G. 406167 Hamilton I. 3331197 Gronowitz S. 1821279 Gulliford S. P. 4511175 Habibi Z. 2561103 Hamilton J. G. 1851581 Groot A, 5181475 Gulliver B. S. 3571168 Habib-Rehman 589161 74 Hamilton J. G. C. 1421114 Gros E. G. 1891907 384152 57 58 Gumalka M. 971103 1601165 Habimana J-B. 5151150 Hamilton J. T. G. I841456 5 171380 Gumbinger H. G. 4071175 Habrylo S. 5191570 Hamilton N. 38319 Grosch W. 1851550 Gumulka M. 677182 Habsuda J. 618165 Hamilton-Kemp T. K.,1851558 Grosche M. 5191503 Gumusel B. 5181437 Habtermariam S. 255127 Hamit H. 2991300 Gross D. 9811 72 173 Gunasekera M. 29811 75 Hachiken H. 589167 Hammann. P. 651168 Gross E. K. M. 618167 Gunasekera S. P. 2981175 6501.59 Hacksell U.5201646 Hammer J. 218176 Gross L. M.. 356166 Gunatilake A. A. L. 4081213 Hadar Y. 1851562 Hammerschmidt R.. 9811 74 Gross M. L.. 1871776 Gunawardana P. 20159 Hadero A. 4521183 Hammes G. G. 3581207 218 Grosselindemann E.. 241133 Gunawardena N. 3581191 Hadi A. H. A, 405/25. 588/37 Hammond D. L. 4091294 Gundidza M. 5 161230 677166 Hammond E. G. 1841511 Grosso N. R.. 5161238 240 Guner H. 2971124 Hadida S. 588114 Hammond G. B. 5181459 Grostic M. F.. 450178 Gunji H. 555178 Hadjiakhoondi A, 5161257 Hammond M. W. 386/216 Grosz M. 5141100 Gunning P. 97194 Hadjieva P. 5191486 Hammouda F. M. 5161250 Groszek G. 2981232. 233 303114 Gunsberg S. 3571145 Hadju E. 2981208 Hamowy A. S. 4101430 Grote J. 3851175 Gunstone F. D. 17914 9 180181 Haffner C. 3861226 Hampp R..602150 Grote R. 4511144 65912 120 1861669 1871706 707 708 Hafner E. W. 5551111 Hamraoui A. 514165 Groth I. 971132 709 710 712 714 715 717 723 Hagaman E. W. 81/16 Han B. H. 741260 82121 41 Groth J. 971118 726 727 734 743 Hagashita S. 296140 Han G.-Q. 731134. 135 Groth U. 218134 Gunther G. 1611250 Hagelstein. P. 602149 Han H. J. 5901138. 139 Grothaus P. 1431200 1441254 Giinther S. 3571138 Hagesawa T. 450181 Han K. 256190 Grotjahn D. B. 303125 Gunzler V. 3321187 Hagget J. 255116 Han M. 3851152 Grove J. F. 1431190. 241117 Gunzler V. A, 3321182 Hagglund I. 1861664 Han X.. 4081252 Grove M. D.. 911 23 Guo C. 1831339 Haginiwa J. 5221773 Han Y. 2991295 Gruber K. 5 151220 Guo L. 3021494 3581197 Hagishita S. 218166 Han Y. N. 82141 Grue M. R. 660160 61 3851198 406183 Hagler.Jr. W. M. 3916 7 9 Hanaki A. 635121 Grundemann E. 303112 13 Guo T. 5191511 635/6 7 Hanaoka M. 4071172 6511104. 105 Grundon. M. F. 20126 31. 32 Guo W. 5161266 Hahn F. M. 602191 Hanauske-Abel H. M. 3321182 6 18/33 Guo X. 71127 28 Hahn R. 4071175 Hanck C.. 981151 Grunler J. 142190 Guo Y.. 2971154 5151163 210 Hahn S. K. 1841455 Hand B. H. 1591108 Grzybowska J. 1101101 Guo Z. 96/51 1431195 201 202 Hai T. 101100 Handa R. J. 4091351 Gschwend. P. M. 463167 Gupta A. K. 3861237 Haibara K. 450182 Handjieva N. V. 618126 Gu J. 109174 Gupta J. 6791228 Haidour A. 731130 741261 262 Hanefeld U.. 462118 Gu P. 3581197 Gupta K. C. 384153 Hailes H. C. 5551119 120 121 Haneishi T. 5211730 Gu Z. 677171 72. 73 74 Gupta K. R. 6771104 Hain R. 9811 71 Hanessian S. 10813 Guan F.406173 Gupta M. 6791210 Haino. T. 3011426 Hang L.. 384167 Guan M. 10174 Gupta M. M. 5161258 Haisma H. J. 109134 Hanhinen P. 588116. 18 19 22 23 Guarnieri W. 401150 153 636197 Gupta M. P. 5211684 617121 Hajdu J. 24311 90 3321189 372174 36 Guay J. 71146 406146 Gupta R. 3861233 234 Hakamata H. 159193 Hanis T. 185/610 Gudbjarnason S.. 1881810 Gupta R. K. 40189 203126 38316 Haken J. K. 1801116 Hanisch F.-G. 10818 Gudehithlu. K. P.. 4091305 Gupta S. 721121 741232 Hakk H. 1821300 Hanley. A. B. 2191104 Gudmestad. N. C.. 1811205 Gupta V. 109166 Hakuta T.. 186/654 Hanley K. M. 6031133 Hale R. S. 3571107 5561172 173 Hannemann K. 1821267 1851538 Gudmundsson B. 0..1881853 Gupta V. K. 475158 618161 Hale T. I. 4511126 Hanners J. L. 218176 219196 122 Guella G.1621350 296178 2981220 Gupta Y. K. 255152 Halim A. F.. 203144 4061116 Hano Y. 602155 56 2991271. 427116. 463155 56 57 58 Gurek F. 2571216 474120 635183 Hanover J. W. 5161247 60 61 63 64. 4641114 Gurib-Fakim A, 5141131 5151143 Halinska A. 1441218 241166 Guenard D.. 25711 72 177 213 5 161245 Hanquet B. 6791201 2421138 Guentert M.. 5211705 Gurjar M. K. 39114 1821330 63519 Haliwell J. E. 4521182 Hanscomb G. 33012 39 Hansen C. E. 1811163 Guerche P.. 1871785 Gurr M. I. 180161 Halkier B. A, 372164 65 66 Hansen H. F.. 71124 Guerero R. 659129 Gurudutt K. N. 5171386 Hall A. F. 10182 Hansen H. J. 4101443. 41 11445 Index of authors cited 1-61 Hansen J. J. 4101437 Hansen K. 3311108 Hansenne M. 4071195 Hanski C. 10818 Hanson J. R. 1591107 240115 16 241117 18 20 35 37 40 57 72 24211 80 181 182 183 184 2431197 200 25511 2561129 134 38311 38 384142 51 112 Hanson K.M. 2981241 Hanson K. R. 4521195 Hanson M. 383135 36 Hansske F. 1601154 Hansson T. 1431176 1601166 Hansson U. 1821279 Hantash F. M. 1811164 Hanzawa Y. 3851194 Hao X.-J.,203120 255154 428170 Hao Y. 4111461 Hapke H. J. 405111 Hara H. 406140 4071184 Hara M. 371135 Hara N. 255152 2991302 6771100 6781200 Hara S. 1851528 462120 22 Hara Y. 1821257 Harabe T. 1821326 Harada A, 9155 Harada E. 5 171347 5 191488 Harada H. 296140 Harada K. 5151156 Harada N. 1611264 2991264 5561154 Harada S. 3851194 Harada T. 5181440 Harada Y. 4081282 Haraldsson G. G. 1881810 853 1891910 Harayama Y.40711 71 Harborne J. B. 9611 2 3 4 5 97169 105 981159 161 162 175 176 177 191 331187 88 89 95 122 Harden D. 589171 Harder P. A. 1421113 Hardie D. G. 141143 1801139 Hardie J. 96130 31 Harding W. W. 67614 Hardt I. H. 1601147 1621342 Hare J. D. 97199 Hareau-Vittini G.,2991305 306 Hargreaves J. A. 141129 Haribal M. 971110 Haris P. I. 1801121 Harlan R. E. 4091346 Harlos K. 2431190 3321189 372174 Harmatha J. 97191 Harms K. 6361114 Haro D. 141120 Harper D. B. 180184 1841456 Harper J. K. 589180 Harper K. K. 158127 Harper M. K. 2981211 2991267 Harraz F. M. 475164 677153 Harrewijn P. 971122 Harris A. 240114 Harris C. H. 1851608 Harris D. J. 401130 Harris J. M. 3851161 Harris M. A. 331189 97 122 Harris R.K. 383112 Harris R. V. 3321195 Harris T. M. 1851569 Harrison L. J. 741268 1611219 1621345 Harrison P. 3581251 252 Harrison P. J. 296177 Harrison R. 109171 Harry B. S. 39/60 Hart D. J. 651184 Hart J. A. 218170 Hart T. W. 1801122 Hartleb I. 6781181 Hartley O. 635135 Hartley S. E. 514166 Hartley T. G. 618168 Hartmann E. 1811186 3571155 Hartmann R. 5211683 Hartmann R. W. 3841120 Hartmann S. 356198 Hartmann T. 96110 11,371120 659141 43 46 660151 63 Hartmans K. J. 5171370 Hartsel S. C. 110199 Hartsuck J. A. 241122 Hartwick R. A. 179134 Hartwig W. 218134 Hartz R. A. 428182 Haruna M. 20153 5211676 Harusawa S. 428141 Harvey P. J. 1431163 1601123 Harvey W. E. 2421179 Harwood J. L. 180161 356135 3571164 Harwood J.S. 96121 Harwood L. M. 474128 475154 Hasan C. S. M. 4071181 Hasan M. 383120 21 Hasbun C. 97194 Hase A. 1811173 1831359 Hase S. 635124 Hase T. 71117 18 38 1821256 1831359 2571220 221 3001373 374 3011424 425 3851133 5221804 Hase T. A, 71141 Hasegawa A, 10818 Hasegawa K. 981148 Hasegawa M. 96134 Hasegawa T. 72/77 Hasegawa T. 16 11288 463194 555164 65 66 Haselkorn R. 356165 Hasen A. J. 4081235 Hasha D. L. 5191550 Hashem M. A. 159156 Hashidoko Y. 1601192 Hashiguchi S. 428140 Hashiguchi Y. 4101394 Hashimoto G. 5211746 Hashimoto H. 1851586 587 3571149 Hashimoto K. 463127 513135 5 191567 Hashimoto M. 331150 450139 40 5551100 Hashimoto S. 1601179 5161244 Hashimoto T.20154 159168 160l126 1621335 336 348 255120 55 2571229 4281103 475111 7 6 18/69 75 650113 Hashimoto Y. 741237 263 5171314 Hashimura K. 659111 Hashish N. E. 4061116 Hashizuka T. 1611208 Hashizume R. 1871798 Haslam E. 44911 Haslinger E. 8111 2561110 Ill 6781157 Hassam S. 6031103 Hassan A. M. 555158 Hassanali A. 97198 5151196 5 161243 677177 78 Hassanien M. M. 514191 HaDlacher M. 3571141 Hasson E. P. 241179 Hastings J. W. 463135 36 Hasumi K. 141146 159143 Hata T. 296126 37 4511149 4631100 Hatakeda K. 1861662 Hatakeyama S. 428158 5181473 474 Hatam N. A. R. 255126 Hatanaka A. 1811150 222 Hatanaka H. 450137 38 39 40 5551100 Hatanaka Y. 1591104 4081237 Hatano A, 1591113 Hatano K. 1841485 4511102 4751117 Hatch M.W. 1421105 Hatfield R. D. 72162 Hathout Y. 3571152 Hatogai K. 159180 3001336 Hatori A, 741276 Hatori M. 555160 62 65 66 Hatsui T. 1611272 273 5171394 Hatton I. K. 2421179 Hattori K. 5201593 Hattori M. 741216 21 7 474123 Hattori T. 331155 Hatzoglou A. 4091364 Hau C. K. 256186 Hauck C. 981150 Haufe G. 5191503 Haughey H. M. 4101396 Havel R. 180177 Haver H. 5221798 Havstad K. M. 5151153 Havukkala I. 462122 Hawes G. B. 2991290 Hawker J. 241157 2421180 Hawkins C. J. 3011443 Hawthorne J. N. 179124 Hay M. E. 462119 Hayaashi I. 3331214 Hayakawa Y. 4511168 5551104 Hayamizu K. 1861700 Hayasaka T. 109136 Hayashi A. 1801119 Hayashi H. 731132 4291110 5181424 5221809 Hayashi K.72170 463175 513135 676145 Hayashi M . 5 191492 Hayashi N. 40190 971111 113 160l141 635159 60 660147 Hayashi S. 2991275 Hayashi T. 371138 463190 97 Hayashi Y. 401155 741222 159140 6361128 Hayashida M. 3331214 Hayatsu K. 741276 Haycock P. R. 1871744 Haydock S. F. 356176 3581221 450120 45 46 Hayes D. G. 1881824 854 859 Hayes E. C. 109145 Haynes R. K. 1601138 Haynes U. J. 3311113 Hazarika A. K. 5141129 Haze S.-I. 3581242 Hazebroek J. P. 241164 Hazell A. C. 72199 He C. H. 2571160 162 167 3011490 He H. 3001380 406180 He H. M. 406189 He H.-M. 384185 86 He J.-Y.,372193 He L. 4101391 6771116 He M. 617112 He Q. Y. 406174 He R.-Y. 9/68 He W. Y. 2571162 6781176 He X. 617112 He X.-G. 4511106 5561133 He Y.5151183 5211748 He Z. 5211726 5221793 He Z. D. 5161265 5221756 757 He Z. Y. 6771107 He Z.-S. 6791230 Heath R. R. 96136 97186 123 Heathcock C. H. 411161 2571194 Heavers A. D. 1831358 1841469 Heble M. R. 635128 Hebler-Klintz M. 1101107 Heck J. V. 109188 1831367 Heckendorn R. 384178 Hecker E. 2571213 Hedaya S. D. 4091338 Hedden P. 1441222 224 226 229 232 233 Hedge M. 3841115 Hedner T. 4091288 Heer J. P. 5201649 Heffer M. 4091304 Heffner R. J. 82165 67 Hefner J. 1441251 252 Hegardt F. G. 141119 20 27 Hegarty P. K. 602119 Hegde V. R. 6781198 Hegedus L. S. 218173 Hehenkamp J. J. J. 2191117 Heide L. 450172 4511136 Heidepriem R. W. 38318 Heijnen. J. J. 372150 Heiker F.-R.,4511148 Heiman A.S. 3851147 Heimscheidt T. 371118 Heinanen M. 5201659 Heine J. N. 463162 Heinrich M. 731185 Heinstein P. 1431164 602186 Heintze A. 142156 602149 51 Heinz E. 1871722 3571173 Heinz H. J. 179142 Heinzmann B. M. 6781177 Heisler T. 650160 Heldal J. A. 1841494 Helentjaris T. 1441220 241186 Helfrich W. 1801141 Hellman U. 1441241 Hellou J. 3001409 Hellstrom I. 109132 Hellstrom K. E. 109132 Helm D. 5561189 Helmchen G. 158132 Helmke E. 296130 428159 Helmke H. 636197 Helms G. L. 1591101 Helquist P. 1821320 Hemamalini P. 5181461 Hemamalini S. 297188 Hemling M. 3011467 Hemming F. W. 179124 Hemptinne J. L. 650155 Hemscheidt T. 371117 553111 35/90 65 11122 Henderson I. 218188 Hendlin D. 330133 43 45 Hendolin H.4081277 Hendra P. J. 1861694 Hendriksen S. J. 4091333 Hendry G. A. F. 981147 Henin F. 5201615 Henion J. D. 1871779 Henke H. 428136 Hennig B. 1861681 Hennig H. 5191503 Hennig P. 5 151209 Henning U. 602130 31 59 Henningson P. J. 1811205 Henrichs C. 635178 Henrici A. 721122 Henrikson K. P. 356173 Henriques A. T. 5151152 212 588140 Henriques J. A. P. 4071132 Henriques S. A. 659145 Henry K. J. 589198 Hense T. 401150 636199 Hensens 0. D. 1591101 330144 55611 2 7 Henson L. G. 4101379 Hepburn P. 3321129 Hepperle M. 2571180 Herald C. L. 203129 2981195 3001393 30 11485 Herald D. L. 2981191 218 Herbert C. M. 109188 Herbert R. B. 37111 2 3 4 5 6 7 32 44 372183 4101441 4511175 45211 77 178 I79 Herbert R.H. 650139 Herce M. D. 5561170 Herczegh P. 39132 45 Heredia A, 4101378 404 Herling H. 1871722 Herlt J. A. 451199 Hermes J. D. 141118 Herms D. A. 96146 Hernandez A, 650142 Hernandez C. 555184 85 86 Hernandez J. 72149 Hernandez J. D. 2561121 Hernandez J. D. 1601143 144 145 1621306 Hernandez K. M. D. 96136 Hernandez L. 40511 Hernandez M. 4091331 Hernandez M. G. 2561128 Hernandez M. G. 1611221 475196 Hernandez R. 384180 Hernandez S. 330133 43 45 Hernandez-Bautista B. 1611213 Hernandez-Galan R. 1601155 1-62 Natural Product Reports 1997 Hernandez-Ortega S. 255163 Hirata A. 462122 Hogg R. W. 1811193 Hoppe I. 401150 6361114 2561104 Hirata T. 5171361 363 385 Hogge L. R. 1431186 Hoppe P.602149 Hernez C. T. 5211699 5 191492 60213 7 Hohmann J. 1611250 Hopper E. L. 1431175 1621316 Hernqvist L. 1801101 Hirata Y. 2991294 330 463179 Hohn T. M. 1431140 141 150 152 Hopwood D. A. 4511131 554125 Herrera-Marschitz M. 4091353 65 1/70 155 156 157 188 189 26 27 28 29 30 31 32 46 Herrick I. W. 1851527 Hirayae K. 462122 Hokfelt T. 4091336 5551116 5 5314 Herrmann K. M. 372156 Hirobe C. 677187 Hokland B. M. 1831416 Hoquemiller R. 731168 Herrmann R.. 5191565 5211670 Hirohara M. 6791238 Hol T. 4091297 Horbach S. 142154 602128 45 Herrold R. E. 4511151 156 Hiroi K. 5171316 320 321 Holden J. L. 1841452 3571128 Hori M. 449110 450115 Herslof B. G. 17914 1861631 Hirokawa T. 514168 Holderna-Natkaniec K. 5 19/570 Hori T. 74/21 7 Herve M. 1101100 Hirono S. 6771102 571 Hone M.2551'20 Herz W. 15811 1601184 189 195 Hirose M. 406195 Holdom K. S. 5551111 112 Horiguchi Y. 20123 1621304 255175 25611 19 Hirose T. 5171359 Holeman M. 514165 Horii S. 4511145 Herzberg O. 3321140 Hirota H. 2581241 2981244 Holker J. S. E. 5561187 Horikawa H. 721120 Herzberg R. P. 2981207 2991280 Holl G. S. 46211 7 Horinouchi S. 3581238 553116 17 Herzog R. 82137 39 48 51 Hirota T. 3861228 Holl N. D. 4641111 554120 21 555182 Hesbacher S. 96/19 20 Hirotani M. 14311 78 1591113 Holland D. L. 1811238 Hormer M. 5151188 Hesketh A. R. 1431153 154 676130 Holland H. L. 3841119 Horn M. H. 741245 Hesse M. 72178 741228 303110 11 Hiroya K. 589195 6511117 659111 Holland S. 331170 3321162 163 Home D. A. 65017 372167 68 5201590 61717 Hirsch S. 2981209 3011474 166 3331215 Hornemann U.450187 451191 92 Hester J. 41 11460 Hirschberg D. L. 109132 Holldebler B. 96127 28 141 Hethelyi E. B. 5141100 Hirshfield J. 330144 Hollenbeak K. H. 2991291 3001397 Hornfeldt K. 218159 Heumann A. 5171372 5191533 Hirsinger F. 180191 Holley B. W. 5551111 Homing S. 3841124 Hewkin C. T. 5191548 Hirst G. C. 651194 Holliman F. G. 45 111 75 45211 77 Horns S. 1601157 Hezari M. 1431197 198 1441251 Hirukawa T. 1821328 1831341 178 179 Horrobin D. F. 180182 1871804 252 Hiruta O. 1851548 Hollingsworth R. I. 1811185 Hortobagyi G. N. 108113 Hibbard B. 3917 8 Hisamatsu M. 384160 Hollomon D. W. 1811170 Horton P. A, 158123. 28 298/241 Hibberd A. D. 39152 53 Hisatomi S. 5211661 Holloway P. J. 1811170 2991261 268 2 72 Hibi T. 462122 Hisham A. 6771100 Holloway P.W. 3581204 602180 81 Horvat R. J. 5141119 5171367 Hibino S. 3011461 462 427111 18 Hitchcock P. B. 2561129 383138 Holloway S. J. 3571154 Horvath J. 384146 47 48 Hida T. 72150 384142 Hollstein U.,45111 74 45211 76 Horvath L. A. 356136 Hidalgo F. J. 1831343 402 Hitotsuyanagi Y. 731207 208 209 Hollywood R. 1861687 Hosamani K. M. 1821252 Hiegemann M. 1101107 4081224 232 Holman R. T. 1861669 Hose S. 514154 Hiermann A. 474129 Hitz W. D. 3571177 Holmberg K. 1881823 849 Hoshi M. 39127 Hierro M. T. G. 1851609 Hiyakumachi M. 5171364 Holme H. S. 513/19 Hoshino O. 406140 4071184 Higa T. 29811 73 3011490 Hiyoshi N. 2991264 Holmer G. 1851520 1881814 Hoshino T. 1431144 145 1881820 Higashi A. 3581240 241 Hjalten J. 97159 Holmes A. B. 635147 371138 676114 Higashi K.1431145 Hjieva N. 5221769 772 Holmes C. F. B. 2981187 463137 Hoskuldsson P. A. 1881810 Higashi S. 1441217 Hjortso M. A, 1431175 1621316 Holmes D. S. 10816 Hosny M. 522l750 751 754 Higashidate S. 1861650 Ho D. K. 1811182 Holms W. H. 3331197 Hosoi S. 4111458 459 Higashide E. 450181 Ho F. C. 474135 475160 Holspoer F. 4091308 Hosokawa N. 449110 450115 Higashiyama K. 401141 Ho M.-F. 3321148 150 152 Holthuijzen J. 513122 Hosomi A. 5181441 444 Higgens C. E. 33011 331183 84 Ho S. N. 109167 Holton R. A. 2561149 5201598 Hosomi K. 513137 Higuchi K. 10191 Ho T. L. 1601130 1621355 2991273 Holub M. 161120.5 1621323 Hosoyama H. 2571158 159 Higuchi R. 2571218 3001376 394 Hoad G. V. 2421164 Holz Jr. G. G. 3571124 Hospital S. 1831350 184/459 30 11472 4 73 Hoang T. D. 463196 Holzer K.P. 3581207 Hossain C. F. 4751102 Higuchi T. 71113 72/55 Hobbs L. 2981215 2991300 Homann K. 635120 Hossain M. B. 2991291 3011442 Higuchi Y. 142185 Hobbs S. C. 650132 39 Homberger K. 372/67 428190 463125 91 5561189 Hildebrand D. F. 141139 1851558 Hoberg M. 1841451 3571127 Homer R. J. 218127 Hossain M. S. 4071181 6031128 Hobert K. 1101102 106 107 Honda G. 255125 5221789 Hostettmann K. 1621357 5211747 Hildebrandt L. 4091323 Hoch J. 3581213 Honda H. 450136 Hosztafi S. 4081229 236 254 255 Hiler 11 G. D. 1881817 Hockerstedt K. A. V. 71/41 Honda K. 40190 241141 257 Hill J. M. 372185 Hocquemiller R. 20124 61 8131 Honda K. 971111 113 1601141 Hotta Y. 3851177 Hill Jr. C. G. I871790 Hodge J. S. 1621327 635159 60 660147 Hou C. T. 1891889 890 893 894 Hill R.J. I871786 Hodgson D. M. 6361116 117 Honda T. 39/27 72196 109177 Hou C. Y. 522l794 Hill R. K. 218166 450131 Hodgson J. E. 3321165 166 167 513117 659113 Hou G. 5151211 Hill S. E. 428193 168 372171 Honda Y. 5181430 Hou R. S. 2571195 3001342 Hillebrand D. 82/53 Hodgson P. K. G. 5201631 Hondi A. A, 4101390 Hou W. Y. 4081278 Hillemann H. 4511163 Hodson H. F. 384169 Hong B.-C. 659118 Houba P. H. J. 109134 Hiller K. 6781130 146 6791202 Hoebel B. G. 4091360 Hong H. 651167 Houck M. A. 6361134 Hills M. J. 1881835 862 864 865 Hoeck A. C. 2191118 Hong S. 474147 Houghton P. J. 428147 5221767 Hiltmann A. 1101102 105 Hoeglund P. 4101393 Hong S. H. 4071152 House A. P. N. 5151142 Hiltunen R. V. K. 5161281 Hoegy S. E. 401144 Hong S. L. 1611247 House R. V. 4101406 Himes R.H. 2571176 192 Hoehn M. M. 33011 331183 Hong X. 203120 Houser R. P. 5181442 Himmelreich H. 741231 Hoemann M. Z. 2571179 186 Hong Y. H. 4071122 Housley T. L. 97164 Himmelreich U.,741239 677197 Hoernecke R. 4091356 Honjo C. 9119 Houston T. A. 3331218 372169 Hino A. 3001393 Hoerr D. C. 1861644 Honma K. 2971149 2981236 237 Houze J. B. 516/296 Hino H. 406143 Hofer A. 97168 428174 Hovenier R. 2561116 Hino T. 428135 Hofer O. 731167 617114 Honma T. 4291107 Howard S. 39141 Hinomoto T.. 296171 Hofert P. H. 731200 Hoock Ch. 384166 Howarth 0.W. 741238 38317 Hintz H. P. J. 450180 Hofle G. 4521187 463154 553110 Hood J. D. 33012 40 42 Howarth T. T. 330137 38 41 Hintze F. 401150 5561149 61 7/20 Hooft R. W. W. 383129 331187 88 89 94 95 96 99 Hinze C. 650/12 Hogenauer G. 356/55 Hoogmartens J.109192 Howe J. 602/86 Hiraga Y. 142158 95 5161273 Hohne E. 618160 Hoogsteen K. 1601158 330144 Howell A. L. 4091323 5171354 377 Holder S. 371127 Hook D. J. 44914 Howells J. D. C. 96/45 Hirai K. 4071192 Hoffman G. 179141 Hooper A. M. 5551113 Howie G. A. 450180 Hirai N. 72157 741240 981187 Hoffmann D. 731205 4511137 138 Hooper G. H. 15813 Hrazdina G. 6031112 158136 37 Hoffmann E. de 4071167 Hooper G. J. 2571219 2991332 Hsaio J.-J. 2011 Hirai Y. 6771102 Hoffmann H. M. R. 5191516 519 3001378 30 11430 Hsieh C. Y. 4081278 Hiraishi S. 5211708 5891106 107 Hooper J. N. A. 15814 2981194 Hsieh H.-P. 3851167 Hiraki Y. 406172 Hoffmann J. J. 255119 195 215 218 224 240 2991270 Hsieh M. T. 4071138 Hirakoso K. 72147 Hoffmann K. E. 4091310 300 Hsieh R. H.1801130 Hirama M. 39131. 651188 Hoffmann L. 296154 462116 Hootele C. 651164 65 83 Hsieh R. J. 1851533 Hiramatsu H. 721120 Hoffmann M. 1621314 5161293 Hopfmann T. 296157 427113 14 Hsu H. Y. 731152 Hiramoto S. 44919 Hoffmann R. W. 6361119 Hopia A. I. 1851524 HSU,K.-S. 618173 Hirano J. 1871798 799 1881860 Hoffmeister H. 1861622 Hopke J. 1431181 HSU,L-F. 5211728 738 739 Hirano M. 555161 Hofmann U. 4101399 Hopkins T. 3011481 Hsu N. 1841497 498 Hirano T. 71134 Hofstead S. J. 1101109 Hoppe D. 401150. 151 152 153 Hsu V. L. 296152 462113 Hirasawa K.. 5171316 Hoge J. H. C. 602114 636197 98 99 100 114 Hu B. H. 6781135 Index of authors cited 1-63 Hu G. 4071144 Hulya A, 5181437 Hu J. 4071188 5211710 Humbert T. 1841489 Hu J. F. 6771120 Hume S. D. 1421106 Hu L.5171307 Humphrey G. R. 386/227 Hu M. 6781191 Humphrey J. M. 218170 Hu M. L. 1841510 Humphrey P. E. 5561171 Hu Q. 5171388 Humphreys V. M. 255116 Hu S. 4091322 Hunaiti A. R. 3571106 Hu S.-F. 588141 Huneck S. 255148 Hu T. 1841448 296163 64 65 Hung N. V. 58819 3011427 463138 5191575 Hung S. M. 5201609 611 Hu W. 5201605 606 Hunt E. 331189 90 91 97 99 100 Hu X. E. 1811182 101 102 103 Hu X.-Q. 401116 117 Hunt J. A, 39126 Hu Y. 3851137 138 151 152 Hunt M. B. 97196 450161 4511160 Hunter J. E. 40186 589163 Hu Y. F. 4071146 Hunter L. M. 1811218 Hu Z. 5 191511 5551116 Hunter M. D. 97170 Hu Z. L. 1811228 Hunter N. R. 1801131 6511119 Hua D. H. 63415 635131 Hunter P. A. 331159 60 65 104 Huan J. 660175 Hunter W. N. 108111 Huang A.-C.20129 Huopalahti R. 1861659 660 Huang B. 5181410 5201607 Hupperts A, 20121 2981217 Huang C. H. 1801140 Hur C. U. 72197 Huang D. F. 650131 Hurst D. T. 20139 Huang F. M. 4061105 Husain S. 1871716 384153 Huang F. Y. 4071191 677177 78 Husband S. 4081230 231 Huang H. 10814 159169 1621354 Huser N. 651181 4071137 Hussaini F. A. 741232 Huang J. 1431172 Hussein N. S. 1621303 311 Huang J. K. 1891899 Hussey C. E. 1421112 Huang K. X. 1881818 819 4071146 Husson G. P. 30316 Huang L. 55611 76 Husson H.-P. 58817 12 37 Huang M. F. 5211727 635150 6511102 Huang M. Q. 1811159 Hutchings D. E. 4101430 Huang M.-Y. 731132 Hutchinson C. R. 4511124 553118 Huang P. Q. 5211697 635156 554135 36 37 38 39 40 41 42 Huang Q. 20140 731135 1591104 43 44 45 555177 78 Huang R.C. 97193 677185 86 88 Hutchinson J. H. 71146 Huang R. C. C. 71145 Hutchison M. 241174 2431194 Huang S. 1101109 2571190 Huth A. 427130 296159 60 Huttly A. K. 1441226 2421122 Huang S.-C.,618171 Huttner G.,6361123 Huang W. 4071140 141 Hutton C. A. 218174 Huang W.-Y. 3571143 3581208 209 Huu T. N. 58819 Huang X. 2571209 3001357 Huxtable R. J. 660159 65 66 67 Huang X. P. 971104 115 68 69 70 71 Huang Y. 67619 I0 Hvattum E. 1831416 418 Huang Y. L. 731152 Hwang C.-S. 3581232 Huang Y. S. 1871804 Hwang I. 2421124 Huang Z. 4071140 141 Hwang S. H. 4071122 157 Huang Z. H. 1871748 749 750 Hwang Y. S. 158138 5211675 751 752 756 759 770 Hy X. 5201654 Huargliang Y. 5151181 Hyakutake H. 981194 Hubbard B. R. 1431148 Hylands P. J. 4061115 602158 Hubbell C.L. 4091292 4101422 Hymansky A. 4101405 Huber G. 1101102 107 Hyun J. W. 4751100 Huber R. 1811207 Hyun K.-H. 9131 Huber S. K. 5201599 Hyvarinen H. 1811183 Huber U. 1431182 Hyvonen L. E. T. 1851524 Huber W. 1861667 Huber-Patz U. 5181472 478 Huch V. 2581231 I Hudhomme P. 218163 Hudson B. S. 1841480 Hudson J. K. 1861648 649 Iacazio G. 1881885 Huefner A. 2561111 Iadarola M . J. 4091336 Huel C. 618179 Iason G.,97157 Huet J. C. 981157 Iason G. R. 514166 Huether M. J. 4091357 Iavorone C. 5211742 Huff B. 82162 69 Iba K. 3571176 Huffman J. W. 5221812 Ibberson P. N. 4521178 Hufford C. D. 1601136 2581240 Ibe S. 1611220 Hufschmid E. 4101398 Ibhi S. 160JI69 Hug P. 4281102 Ibraheim Z. Z. 401106 158117 Hugh-Block M. 6781157 16 11258 Hughes C.E. 4091298 Ibraheim R. K. 142163 64 84 Hughes D. W.. 3841104 601110 Hughes J. V. 3841109 Iccho K. 602137 Hughes L. R. 635147 Ichiba T. 1841454 2971160 29811 73 206 248 428194 Hughes M. A. 1851554 568 Ichihara A. 1811220 296158 Hughes S. H. 475173 55611 83 I84 Hugly S. 3571176 Ichihara Y. 731208 203127 28 Huguet J. 1821309 2971169 2981194 Huh H. 371131 3001389 390 3011483 Huh M. G. 4091299 Ichii H. 1421106 Hui H. 5151211 Ichikawa Y. 1441244 Hui S. C. G. 406191 92 Ichimaru M. 20116 406138 617115 Hulst R. 40516 Ichimoto I. 5141130 1-64 Natural Product Reports 1997 Ichinohe Y. 384154 Ichinose K. 554146 Ida Y. 6771102 6781133 Idetsuki H. 515/156 Ideura N. 6771102 Ido T. 1841462 485 Idoji M. 676135 Idrissi A.I. 514187 Iengo A. 2991278 Ifuku O. 3581242 Igarashi J. 109126 Igarashi T. 463177 Igawa T. 2571221 Iggo J. A. 5891116 Iglesias J. 514187 Iglesias L. E. 1891907 Iglesias T. 3011439 Iguchi H. 1841516 Iguchi K. 2571211 2991316 327 3001359 385 Ihara M. 1621353 3001341 428183 Iida A. 255125 2561120 Iida H. 39170 Iida S. 1841485 Iijima Y. 296137 4631100 Iinuma H. 5561134 Iinuma M. 255162 513134 Iinuma N. 450115 Iio T. 1851531 Iitaka Y. 1621329 4511172 Iizuka Y. 72153 Ijiro K. 1881848 Ikai A. 35513 Ikariya T. 428140 Ikeda C. 555160 Ikeda D. 46217 Ikeda I. 42714 Ikeda K. 1611210 Ikeda M. 731187 9121 27 1871775 383118 41 11459 Ikeda S. 1611272 Ikeda Y. 5171361 Ikegamu S. 16011 79 Ikegawa S.3851156 Ikekama N. 450/16 Ikekawa N. 9111 21 26 27 30 40 46 48 49 58 10176 84 Ikematsu Y. 5171363 Ikemoto H. 4641109 Ikemoto N. 109162 70 Ikeno S. 449110 Ikeya Y. 71119 72170 108 741214 218 1611253 513135 Ikhiri K. 159139 Ikota N. 635121 Ikushima Y. 1861662 663 Ikuta A. 6771108 6781187 Ikuta H. 4081232 Ila H. 3861237 Ilarslan R. 202113 Ileiva E. I. 5221769 Ilett K. F. 401130 Iliceto G.,4081205 Ilieva E. 5221772 Ilkoy E. 383133 Ilyas M. 4751120 Ilyasov A. V. 1851561 Imada A. 331152 Imada C. 296129 462120 Imagawa H. 158111 Imai A. 5171329 Imai S. 741253 256198 101 4511168 Imai T. 5171330 72153 Imai Y. 3581233 Imaishi H. 1431145 Imaizumi S. 356190 Imamura K. 677193 Imamura P.M. 1611239 Imanaka H. 450139 Imanishi T. 2561131 Imbs A. B. 1811160 174 178 1861672 Imre S. 2971124 Imtiaz U. 3321141 Imunara N. 450138 In Y. 2981205 3011441 4071119 Ina K. 1611274 4631101 5161263 266 Inaba K. 428174 Inaba S. 741276 Inabe H. 4101387 Inada A. 676141 6791237 Inada Y. 1881837 Inagaki J. 5161263 264 Inamori Y. 72148 Inamura N. 4631105 Inatomi N. 109190 Inatomi Y. 676141 6791237 Indep M. A. 1611267 Indo M. 5181398 Ine O. 1621356 Ingledew W. M. 4521182 Ingram T. J. 241183 2421135 136 Inman W. 2991272 Innis S. M. 1811149 Innocenti G. 47414 Ino C. 1431178 1591113 Inokoshi J. 3571149 Inou M. 203129 Inoue A. 1601192 296166 463144 Inoue H. 1431136 137 138 139 15815 Inoue K.5161265 5221755 756 757 Inoue M. 296141 3011485 618157 6791246 Inoue N. 4101370 Inoue S. 2971164 3011486 589190 Inoue S-I. 5161298 Inoue T. 9152 54 10189 90 94 2561131 513113 514174 5171379 Inoue Y. 109136 5181432 Inouye M. 555182 Inouye Y. 1601161 Intert F. 513122 Inturrisi C. E. 4101405 Inubushi A. 2571159 Invernizzi A. G. 2581236 237 Iodice C. 2971110 2991265 308 309 3001364 3011476 479 480 481 Ione K. G. 5191574 Ioneda T. 1871783 Iossifona T. 5221758 Iouzalen L. 4071160 428187 Ip S. P. 72151 Irel C. M. 46218 4641113 Ireland C. M. 1811214 2971143 2991262 3011437 449 465 Iribar J. 255143 Irie H. 731173 428158 5181473 474 5211733 Irie K. 5221809 Irie T. 297192 Irngartinger H. 5181472 478 Irschik H.553110 617120 Irwin D. 41 11457 Isaacson R. E. 109186 Isaev M. I. 676124 25 26 27 29 32 Isakov V. V. 3011448 Isamukhamedov A. Sh. 1821263 Ishibashi E. 676114 Ishibashi H. 731187 1611261 Ishibashi M. 9124 158124 1841447 296161 76 2971146 158 162 163 2981202 2991304 3011431 432 3571117 463152 79 5561139 650122 24 650124 65 1/70 72 73 74 Ishibashi Y. 463142 Ishibashi Y. S. 65018 Ishida H. 981187 3011428 3861219 Ishida N. 109172 3311115 Ishida S. 296166 71 463144 Ishida T. 2981205 3011441 4071119 5171311 6791246 Ishida Y. 463150 Ishigaki T. 3001402 403 4641116 Ishiguro K. 1591115 Ishihara J. 2971127 Ishihara M. 1811150 Ishii H. 741247 4071170 171 474124 475162 61711 7 618134 Ishii K.1821266 Ishii S. 677194 Ishii T. 1881882 Ishikawa F. 659113 Ishikawa M. 7311 74 Ishikawa T. 741247 1431167 168 Iwata C. 2561131 132 651169 Jardillier J.-C. 20112 Jiang T. Y.,1621315 203 204 1601124 125 407l170 Iwata M. 406172 Jareonkitmongkol S. 1881874 876 Jiang X. 406182 171 474124 475162 61718 17 Iwata R. 1841462 485 Jares-Erijman E. A. 3011475 Jiang Y.,5191552 5201605 613 627 6 18/34 Iwata-Reuyl D. 3321184 216 221 Jarman C. D. 10180 Jiang Y. Z. 5201606 611 Ishikawa Y.. 731159 229 Jarman M. 3851135 Jiang Z. D. 18 11232 237 1821258 Ishikura M. 428198 Iwatsuki K. 2421161 Jarowicki K. 5201639 3571133 462112 677196 6791222 Ishimara K. 5201653 Iyer M. R. 72160 Jarreau F.-X. 81113 14 16 58 Jiao R. 4511111 Ishimoto T. 406171 Iyer R. R. 1831334 Jarrin J.981184 Jiao Y. I811220 Ishiwata H. 3001405 Izawa M. 297192 450182 Jarving I. 3571129 Jimenez A. 255151 Ishiwata K. 1841462 Izumi S. 5171361 385 5191492 Jarvis A. G. 2561134 Jimenez C. 1811218 Ishiyama T. 555178 Izumi T. 4291110 Jarvis W. R. I811202 Jimenez I. A. 6791209 210 Ishizaka H. 3861219 Izumida H. 2981227 463129 Jaskiw G. E. 4071200 JimCnez J.-M. 588124 Ishizaki M. 589195 Izuta S. 296125 Jaspars M. 158123 2991261 Jimenez L. S. 427121 22 Ishizaki T. 2971164 Izzo I. 2991322 3851209 Jasperse J. L. 1861616 Jimenez M. 1611207 Ishizuaka M. 5561134 Jaun B. 602154 Jimenez R. 406144 Ishizuka M.. 555167 Jawanda G. S. I621305 Jimeno M. 255170 Ishizuka T. 5201629 Jaworski J. G. 3571159 165 166 Jimeno M. L. 6781129 J Islam K. 159145 Jayashankar R.588139 Jiminez A, 255150 Ismail I. I. 4751113 Jayasinghe L. R. 2571179 186 Jiminez I. A. 5211684 Ismail S. I. 5161250 Jachmanian 1881866 659114 6781200 6791216 Jiminez J. 5161252 Isman M. B. 97194 Jack W. E. 463131 Jayasree J. 5171392 5191526 Jin G. Z. 405121 4071136 143 144 Isobe M. 2981206 428194 Jackowski S. 355110 356145 46 47 Jayasree V. 39114 63519 145 146 Isobe R. 255161 3011473 6781162 3 571163 Jayatilake G. S. 2981243 463162 Jin L. 5181453 Isoda S. 6771102 Jackson B. D. 96125 Jean F. I. 2571155 5141108 Jin Q. 5151210 Isoe S. 5181401 5211740 Jackson C. M. 5551119 5 151141 189 Jin W. 406173 Isogai K. 1611220 Jackson D. 331162 63 Jeannin L. 428131 Jin W.-Z. 4511152 Isohata T. 71/13 55 Jackson G. J. 2431198 Jedlicki E. 602197 Jin X. L. 2571162 Isono K.296138 428162 Jackson L. L. 3581192 193 194 Jefferies P. R. 241138 2431192 Jin Y.,5221793 Isotani S. 1841507 Jackson M. 1801121 330133 43 45 Jeffery D. J. 331198 Jin Z.. 4511111 Isozaki Y.,1611210 555172 97 55611 71 Jeffery T. 1821301 Jin Z. J. 2571212 Israilov I. A. 4071180 Jackson R. F. W. 218181 Jefford C. W. 39171 75 40176 Jinadasa S. 1601135 Itabashi Y. 1861637. 641 Jackson R. H. 159150 2991259 3011436 635146 48 Jindal D. P. 3841110 3861232 233 Itagaki F. 2981189 Jackson W. R. 618165 Jeffrey B. S. J. 1861635 234 Itagaki K. 463127 Jackson Y. A. 475181 Jegovov A,,4081253 Jing Z. 5 1511 74 Itahana H. 1621328 Jacob G. 602197 Jehan C. M. 1821253 Jing Z. X. 676120 It6 S. 39131 Jacobs H. 650154 67614 Jenck J. 5181446 Jirik V. 4101442 Ito C. 20153 54 55 56 42719 Jacobs H.J. C. 3861218 Jencks W. P. 356160 Jirovetz L. 514172 85 118 5151164 475164 117. 618169 70 72 73 75 Jacobs M. R. 3311117 Jenkins G. N.,372184 85 214 81 Jacobs R. S. 1811168 169 296179 Jenkins R. 40180 256177 Jirovsky I. 650137 Ito D. I. 142158 95 5161273 Jacobson U. 1621331 677182 Jenkins R. G. 15817 Joannou G. E. 3851145 5 171354 Jacqmain E. 2571155 Jenners L. 677183 Jobamputra V. 331161 Ito H. 731161 3321125 6791242 Jacquier M.-J. 58813 Jennewein H. K. 4081239 Jo Davisson V. 356152 Ito K. 731187 5211676 6361121 Jacquin E. 3581202 Jennings B. H. 1881817 Johansson I. 41Ol400 Ito M. 5211708 589162 Jadhav P. K. 39140 4521192 Jennings J. C. 1431214 241181 Johenning S. 3311117 Ito S. 1861662 2991330 384159 Jaeger W. 514172 Jennings P. W.. 5191538 John P.3321181 45 11149 52 11731 732 Jaen J. C.. 618164 Jensen B. 1861652 Johne S. 20138 Ito T. 1851586 587 463194 5171377 Jaenicke L. 296185 297187 Jensen B. L. 5191555 Johne S. 618160 Ito Y. 428154 Jahan N.,677198 Jensen E. 2411102 2421143 145 Johnson A.D. 3916 Itoh A. 4071161 162 5211743 Jain D. C. 1601137 38314 7 156 Johnson B. F. 462115 5221808 Jain N., 4751101 Jensen J. 3001391 Johnson C. R. 39144 3011491 Itoh M. 5181401 5561191 192 194 Jain P. 40183 Jensen M. S. l8l1211 2971112 6511114 Itoh T. 2991317 Jain S. C. 731125 Jensen P. R. 296127 46218 10 Johnson D. W. 1821297 1841465 Itoh Z. 109189 90 Jain V. K. 3861230 Jensen R. A. 4521181 6031112 Johnson J. 2571182 Itokawa H. 731208 209 1621302 Jakob U. 5211688 Jensen R. B. 71/24 Johnson J. H. 331154 329 337 3001390 393 4081221 Jakobsen 11.B. 971124 125 Jensen R. G. 1851574 Johnson M. A, 1421102 224 232 428150 51 52 677187 Jakuipovic J. 1611252 278 255123 Jensen S. 20122 731144 741232 Johnson P. L. 40186 6791211 256191 103 2571185 406167 Jensen S. E. 331186 3321190 Johnson R. D. 451190 555188 Itou M. 5211704 5 141108 5 191487 333121 7 372170 Johnson R. E. 4101435 Itsuno S. 6361121 Jalal M. A. F. 463125 5561189 Jensen S. M. 5171338 Johnson R. K. 2981207 Iturburu M. 5201644 Jalonen J. 1871771 Jensen S. R. 142/115 116 117 118 Johnson S. B. 1861669 Ivanof A. 217116 James A. T. 3321195 3581235 119 121 122 123 123 125 126 Johnson T. 0..651194 Ivanova D. I.. 4751104 James J. C. 296172 5211719 721 745 5221749 753 Johnston G. A. R. 4291130 Ivanovska N.,4081216 James L.F. 635125 660178 778 788 790 797 799 Johnston J. N.,2971118 Ivessa A. S. 3571141 James P. R. 110197 Jeong J. U. 3011471 3851211 214 Johnston K. 2571184 Ivorra M. D. 4071187 James T. D. 3851180 Jeong T.-S. 2991312 Johnston K. A, 2571189 Iwadare T. 384154 Jamieson D. D. 462117 Jeong Y.C. 72197 Iwagawa T. 1611266 97193 Jamil J. 2571212 Jerkovich G. 1611250 Johnstone C. 1621338 2571202 220 3001346 373 374 Jamwal M. 41 11456 Jerrell J. P. 1851602 Johnstone R. A. W.. 5191535 5211716 5221804 677176 85 86 Janairo G. C. 2571198 3001345 Jeschke W. D. 635182 Jokela R. 588118 22 23 33 42 88 Janaki S. N.,1591105 Jeske F. 256191 Jolivet C. 20158 618179 80 Iwai Y. 159142 4281100 4511149 Janc J. W. 3331222 225 372173 Jessen C. U. 1421119 121 Jolly V. 4751109 Iwakuma T..39131 Jandeleit B. 158113 Jew S.-S. 5901138 139 Joly A. 142165 Iwami M. 450137 Jandke J. 1851572 Jha. A. 741233 Jommi. G. 5201597 5201628 Iwamoto C.. 741248 Janes J. F. 514176 Ji, N.-N. 67811 71 Jona H.. 4291107 Iwamura M.. 5181421 Janez P. 406197 Ji R. R. 4091336 Jonasson C. A. M. 618165 Iwasa J. 1611210 Jang E. B. 96137 Ji Y.Y.,158138 Jondiko I. J. O. 97198 Iwasa K. 407l119 Janick J. 1601133 134 Jia C. 513127 Jones A. D.. 203147 Iwasa T. 4511145 Janin Y. L. 588113 Jia Z. 5221779 780 6771109 111 Jones A. L.. 356135 Iwasaki K. 449111 450113 Jankowski C. K. 109195 1611207 6781169. 196 Jones D. D. 5561200 Iwasaki S. 2571158 3571148 450165 Janousek Z. 660155 56 Jia Z. J. 731162 1611276 277 Jones D. N. 384189. 5201633 5 5611 28 Janout V. 38511 70 Jones D.R. 2981176 Jansen B. J. M. 5181475 476 477 1621292 2571214 215 Iwasaki T. 72147. 101 103 115 Jansen F. J. H. M. 2191121 Jiang A. 384177 Jones D. W. 731193 194 Jiang H. 4071127 Jones. E. A,. 4101384 116 120 731176. 178 191 192 Jansen J. F. G. A. 71135 721117 199 206 255156 5201619 Jiang K. 159198 I16 Jones E. B. G. 463191 96 Iwasawa N. 109158 Jansen R. 553110 617120 Jiang M. 406183 84 4071140 141 Jones M. G. 6511112 Iwase. Y. 40190. 635160 Janssen E. 20121 96128 142 Jones P. G. 1621347 5891107 Iwashima A, 5221809 JBrstian C. L. 6781192 Jiang M. X. 406188 Jones P. H. 109184 Iwashima M. 2991327 3001385 Jaouen G. 384/91 104 Jiang P. 5 151173 Jones P.-J. 356138 Iwashita J. 5201629 Jaouen M. 109194 Jiang S. 660155 56 Jones R. M. 406152 Index of authors cited 1-65 Jones R.R. 109154 Kader J. C. 1871785 Jones T. H. 20133 Kader M. S. A. 96117 Jones W. 20157 Kadkhodayan S. 5201589 Jong T. T. 42718 5201612 Kadota I. 296175 Jordaan A. 20142 Kadota S. 203143 4071147 676137 Jordan K. N. 3571107 Kadouri-Puchot C. 5181468 Jordan P. M. 5561155 159 Kadoya M. 6781148 178 179 Jorge Z. D. 1611257 Kagamihara Y.,5181440 Jorgensen L. 1871729 Kagan V. E. 180151 Jorgensen W. L. J. 383137 Kagasaki T. 296126 Joris B. 330129 Kagayama M. 741243 Jork H. 1611237 Kahan F. M. 330143 44 Jorrin J. 475183 Kahan J. S. 330143 44 Joseph M. 1871785 Kahl J. L. 1851527 Joseph S. P. 618149 50 Kahlos K. 5161281 63411 65 1/62 Kahn P. H. 1601169 Joseph-Nathan P. 20146 159187 Kahne D. 109159 66 16011 43 144 145,170 1621306 Kahne D.E. 109141 57 2561121 428171 Kai L. 406185 Josephs J. L. 475169 Kaib M. 39164 Joshi A. K. 35514 5 3581214 215 Kaimal T. N. B. 1881816 Joshi B. S. 20141 20218 9 10 Kainosho M. 218128 75 372192 6 1 8l5Y Kaiser B. 401151 Joshi V. C. 356116 Kaiser C. R. 5191563 Josien H. 218141 5891128 5901129 Kaiser M. 1101102 Jossang A. 428149 650120 21 Kaiser R. 9617 Jost S. 2571187 Kaji H. 3861222 Josten I. 650112 Kaji M. 1841507 Joubert C. 3841111 Kajimoto G. 1811151 152 1871761 Joulain D. 513123 762 769 Joule J. A. 427119 428168 Kajimoto T. 218189 Joullie M. M. 8115. 6 82163 64 65 Kajiura I. 20156 66 67 68 70 Kajiwara M. 3581242 Journee G.,218177 Kajiwara T. 1811150 222 Jowett D. C. 4101424 Kajiyama K. 257121I 3001359 Joyce G.F. 109160 61 Kajiyama S. 5221809 Joyner H. H. 5221812 Kakela R. 1811183 Juagdan E. G. 2971161 Kakeya H. 296138 428162 Juarez-Martinez G. 475151 Kakinuma K. 2 18/72 372186 Juaristi E. 218155 450116 Jucgla A, 41 11455 Kakinuma S. 555163 64 65 66 Ju-ichi M. 20153 54 55 56 475164 Kakisawa H. 1811203 2981209 1I 7 6 18169 70 72 75 81 3011474 5171364 Julia M. 5211701 Kakiuchi K. 2911103 Julkanen-Tiitto R. 971114 Kakoi H. 3011486 589190 Juma F. D. 20116 406138 617115 Kaku Y.,406141 Jun W. 1881828 Kakushima M. 555160 62 66 Junack M. Z. 372182 Kalaus G. 589187 94 June H. J. 4101429 Kalck P. 5181446 Jung D. I. 1421107 5191490 Kale V. 1861674 Jung G. 450167 Kalechits G. V. 5201576 Jung J. H. 731166 2971168 3001383 Kalemba D. 1591114 5151221 Jung K.H. 372152 5 161235 236 Jung M. 475190 91 Kalidindi R. S. 2971161 Jung S. 1811185 Kalinin A. V. 65911 Jung W. J. 33211 76 Kalinin V. N. 4081228 Jungalwala F. B. 1801106 Kalinovskaya N. I. 296131 Junge B. 4511147 148 Kalinowski H. O. 1611237 Junge D. 3914 5 Kallio H. 1861647 659 660 Jung-Youl P. 296175 1871781 782 5151160 Junior P. 5161268 Kalluri P. 1831398 406 Junjappa H. 3861237 Kaloga M. 721122 475149 Juntilla O. 2421143 144 145 Kalomiri M. 5191549 Junzo J. 6711102 Kalsi P. S. 1621305 Jurayi J. 589170 Kalter K. 3001380 Jurenitsch J. 1611259 162/309 Kaltia S. 1811173 1831359 3011424 5 171328 6781157 425 Jurenka R. A. 3581202 Kalushkov P. 618126 Jurka J. 618167 Kalvoda J. 384178 81 Jursik T. 1861670 Kalyuzhny A. 4091334 Just B.406153 Kam M. 109139 Justice D. E. 6511118 Kam T.-S. 588138 39 589173 75 Jutila M. 1871771 76 78 79 103 Juvonen R. 414113 Kamada K. 158115 16 Jyothirmayi N. 1861696 Kamaev F. G. 255141 Kamakshi C. 731137 Karnal A, 731197 K Kamalaprija P. 5221800 Kamal-Eldin A. 7118 9 Kabat M. M. 38511 73 Kamano Y.,203129 2981191 3001389 390 393 3011485 Kabbara J. 384172 5171322 5181462 Kamat V. P. 5171352 Kabbe K. 463154 Kabieva S. K. 635193 Kamba M. 383118 Kabo G. Y. 5171375 Kamchonwongpaisan S. 5 181485 Kabuto C. 5201636 Kameda K. 3581210 Kameda N. 384154 Kaczka E. A. 330144 Kaczorowski G. J. 1591101 Kameda Y. 741248 4511145 Kadama O. 1601192 Kamei J. 4101432 Kadan G. 72178 Kamei K. 2561131 1-66 Natural Product Reports 1997 Kamel A.1611222 Kamel M. S. 401107 731148 Kameoka H. 731159 165 169 15819 159174 106 1621340 255136 5151184 5 171364 Kamernitsky A. V. 3851153 154 Kameswaran L. 650150 Kamigauchi M. 3011441 4071119 Kamikubo T. 159190 589185 Kamimura M. 1881841 Kamisaka Y. 1851548 1881873 Kamiya K. 6771108 Kamiya T. 331150 Kamiya Y. 1431212 213 1441227 228 236 24019 241146 47 48 87 98 99 100 2421107 110 111 114 2431186 2561137 Kamiyama M. J. 109137 Kamiza M. 384141 Kammerer L. 371127 Kamperdick C. 677180 Kamura A. 1841516 Kan C. 588112 6511102 Kan Y.,20154 741235 158111 25 5/48 2571229 296166 67 68 463139 463144 618169 75 Kanahisa K. 981146 Kanai K. 39127 Kanai Y.,676148 677149 Kanakhin A. V. 635193 Kanbe T.450115 Kanda A. 2561132 Kanda F. 2981202 650124 Kanda Y. 4291123 125 Kande K. M. 4011179 Kandem D. P. 5151220 Kandem P. D. 5161247 Kaneda K. 356190 Kaneda T. 356121 450162 Kaneko C. 5181414 Kaneko K. 4071184 676114 Kaneko M. 4091307 Kanematsu K. 5181482 1611242 2991287 4081242 246 42714 Kanemura T. 428158 Kaneniwa M. 1851543 Kaneto H. 4101427 Kaneuchi S. 41 11458 Kan-Fan C. 58817 37 Kang H. 406184 4071142 Kang J. 411158 159 160 Kang M. S. 39154 56 57 58 59 60 635140 Kang M.-C. 46215 Kang P. M. 618124 36 Kang S. H. 635117 Kang S. S. 731166 4751100 Kang S. T. 1871795 Kang T. S. 635152 Kang Y.H. 741260 Kann N. 1821320 Kannangara G. S. K. 5221813 Kannenberg E. 450158 Kano S. 1601163 Kanodia S.4751114 Kanoh N. 2971127 Kantarjian H. 41 11460 Kantoci D. 2981232 233 Kanya T. C. S. 1811161 Kanyinda B. 406157 58 Kao C. M. 55316 555175 Kaouadji M. 5221763 Kapadia G. J. 82152 Kapil R. S. 255/57 58 Kaplan L. 450144 5551102 5561175 Kaplan M. A. C. 25512 Kappe T. 475197 Karady S. 1831425 Karanja P. N. 1611210 Karasawa T. 5171325 Karawya M. S. 6781195 Karb M. J. 96/47 Kardos-Balogh Z. 650135 46 Kareira P. 96141 Karhunen P. 12/59 Karie J. M. 1601140 Karikas G. A. 5211744 Karim A. 450179 80 5161299 Karim N. 589171 Karimov A. 405113 22 23 31 32 406155 56 60 62 63 65 66 111 4071123 Karimov Z. 1621308 Karinen K. 5891101 Kariya S. 1611261 Karlberg A. T. 256184 Karlicek R. 47419 Karlsson A.450188 Karmat S. P. 159183 Karolak-Wojciechowska J. 159192 Karp F. 141112 Karpha T. K. 1601146 Karst F. 141125 142162 602190 Karstens W. F. J. 218178 Kartner A, 3915 Kasahara H. 731159 165 169 Kasai M. 427123 Kasai R. 731148 255160 2571206 5221784 671156 57 6781132 147 Kasai T. 5171331 Kasal A. 3851132 166 Kasch H. 384166 Kasenov R. Z. 401148 635192 Kasetani Y. 255173 Kashem M. A. 3581218 Kashibe M. 1811222 Kashihara H. 182/313 Kashima C. 5181441 444 Kashiwaba N. 4081225 Kashiwada Y.,71131 44 677170 Kashiwagi Y. 411157 Kashman Y.,650110 6791206 241 Kaska D. D. 3321187 Kasmi H. 5191553 Kaspar H. F. 296169 3011428 429 Kasradze V. G. 5161304 Kass E. 401122 Kastelle A. 371113 Kastner R.E. 331184 Kastner U. 1611259 1621309 5 171328 Kasturi R. 3581208 Kasutoori U. 462121 Kasuya Y. 2191120 Katagiri M. 5221784 Katahira E. J. 142198 Katamura S. 5211740 Katan M. B. 2561116 Kataoka H. 3581201 Kataoka K. 5211731 Kataoka O. 6511104 105 Kataoka T. 1601203 Katayama M. 2191120 Katayama N. 331156 Katayama T. 72156 Kates M. 3571114 Kato A. 20116 406138 617115 Kato D. 72196 Kato H. 981192 1431206 1601192 2981244 Kato K. 5211746 Kato L. 58816 Kato M. 741240 1601193 5191531 Kato M. J. 7114 72187 731136,147 Kato N. 9110 2581232 3321125 Kato S. 1441249 Kato T. 182/328 1831341 2981227 331155 5161303 588125 Katori T. 29711 70 Katsiotis S. T. 5151165 Katsuhara T. 513135 5211741 6 3415 67 912 12 Katsuki H.602141 42 Katsuki Y.,602136 Katsumata A. 428183 Katsumata M. 6781133 Katsumata S. 4101371 Katsumi M. 9165 2421152 Kattah A. E. 4101441 Katz A. 20217 Katz L. 3581220 450119 55316 554123 555171 72 75 76 80 Katzenellenbogen J. A. 383126 384186 92 93 125 126 3851140 589169 Katzir I. 5161287 5171357 358 5191559 Kauffman C. A, 296127 Kauffman J. A. 2981185 Kempka M. 383114 Kiguchi T. 651171 King M.-L. 650126 27 Kauffman R. F. 3851189 Kendrick W. D. 4101385 Kigure K. 1431168 1601124 King R. M. 1611278 Kaufmann T. S. 5171384 Kenig M. 331185 Kihara M. 303115 King T. J. 330137 331182 87 88 Kaul B. L. 4111456 Kenigs V. 4091313 Kihara N. 2981181 95 Kaul P. N. 5151159 Keniry M. A. 109139 Kiji J. 1841507 Kinghorn A.4071178 Kaul V. K. 5141118 5161242 269 Kenji M. 475150 Kikori Y. 6361110 Kinghorn A. D. 255122 67613 Kauppinen R. 5191529 5201659 Kennard O. 108111 Kikuchi K. 1611220 3851170 6791205 Kauschmann A. 10198 Kennedy A. I. 514199 Kikuchi M. 731170 1611281 282 Kingsley S. D. 3841109 Kaussmann E. U. 8112 82173 74 Kennedy E. 3561102 450125 26 475177 5221775 Kingston D. G. I. 1441255 2571178 Kauten R. J. I861699 Kennedy G. D. 589171 Kikuchi S. 356174 78 79 80 188 189 205 3001354 4081213 Kavka P. 4081245 Kenney P. T. M. 383116 Kikuchi T. 20140 741216 21 7 4521188 5 561150 169 Kawabata H. 3851180 Kennish J. M. 1851585 1431205 1591104 255153 2971162 Kini F. 5151158 Kawabata J. 1611265 Kent M. C. 741266 2561107 4081237 676118 19 Kinjo J. 6781162 188 193 Kawabe S.513137 Keon J. P. R. 141129 Kikuchi Y. 65018 Kinney A. J. 35711 77 Kawabe T. 42714 Keppens M. 651198 Kikugawa K. 1851521 Kinney W. A. 3021494 495 Kawada M. 5551118 Kerber V. A. 5151178 Killar L. M. 677179 38511 69 I98 Kawada S. Z. 255156 Kercher T. 65916 Killday K. B. 159150 2991259 Kino T. 450137 38 39 40 5551100 Kawae T. 1431167 203 205 Keriko J. M. 1611210 Kille P. 356135 Kinoshita A, 1871761 Kawaguchi A, 356144 3571148 Kern F. 96127 28 Kilpelainen I. 72158 59 Kinoshita H. 741235 450155 65 5191488 Kernan M. R. 2991298 Kim B. H. 5201641 643 Kinoshita K. 6111113 114 Kawaguchi H. 475164 618172 Kerr A. F. 1841509 Kim B. K. 4751100 Kinoshita M. 463190 Kawahara N. 5181424 Kerr M. A. 5221813 Kim C. 406195 Kinoshita T. 474135 475160 61 Kawai A. 5901133 Kerr R.G. 676123 Kim C.-G. 4511115 116 122 123 Kinsella J. E. 1801130 1851533 Kawai K. 401141 296141 618157 Kerr W. J. 161338 Kim C. H. 463150 618124 Kint S. 514162 Kawai K. I. 4751121 6771113 Kerrola K. 5151160 Kim C.-J. 618125 Kintaka K. 331152 Kawai N. 474130 Kersten R. 659136 Kim C. S. 971106 660147 Kinter C. M. 4081248 Kawai S. 72177 Keshavarz T. 39121 22 635115 Kim D. 513114 Kintya P. K. 6781167 168 Kawaide H. 1441235 236 2431186 Keshet G.,4101414 Kim D. H. 4071157 Kintzinger J. P. 3861215 187 2561136 137 Kessler H. 2981198 Kim D.-I. 3851187 Kinugawa T. 5221810 Kawaii S. 1431144 Kessler J. 4101443 Kim D.-S. 677159 Kinzel J. 71118 Kawakami H. 513116 Kest B. 4081276 Kim E. J. 5191546 547 Kinzy W. 218122 Kawakami T. 1601193 Kester A. 981169 Kim E.-S.,554131 Kirby L.C. 3851168 Kawakita K. 1431158 Kesternich V. 1611206 Kim G. T. 635117 Kirch J. 635169 Kawamura M. 159176 89 5181473 Kettner J. 1431187 Kim H. B. 5201598 Kirchmeier M. J. 4511162 4 74 Kettunen S. 5191566 Kim H. S. 2561117 514193 Kirihata M. 5141130 651177 Kawamura Y. 384159 Ketzinel S. 2571222 3001377 Kim H.-J. 5901138 139 Kirimer N. 5 151188 5 161224 227 Kawanami S.. 5201652 Keudell K. C. 1891899 Kim H.-S. 3851187 4071133 232 248 249 Kawanishi K.. 72166 Keusgen M. 2971108 109 Kim H. Y.,1801118 Kirk J. M. 218181 Kawasaki C. 474141 Keyes M. C. 5181442 Kim H.-Y. 660172 73 Kirk K. 1861697 Kawasaki I. 2981222 Khaitboev M. K. 255141 Kim I. J. 3851184 185,4071122 Kirkiacharian S. 4751105 Kawasaki N. 428174 Khalifa A. S. 401102 Kim I.-C. 3851187 Kirkman L.M. 71139 Kawasaki S. 406172 Khalifa S. I. 1601136 Kim J. 4091299 Kirkup M. P. 296155 Kawasaki T. 428196 Khalifa Y. 5221754 Kim J. B. 4071125 5191520 Kirmizigiil S. 6781186 Kawase N. 299/297 Khalil M. A, 3851148 Kim J. H. 4071125. 157 6771119 Kirschning A. 4511115 116 117 Kawashima H. 1881869 870 871 Khamidov I. 406166 Kim J. I. 411159 Kirst G. O. 463182 872 874 875 Khamlach M. K. 721102 Kim J.-K. 5901138 139 Kirst H. A, 109187 Kawate T. 428134 35 Khan A. A. 5181426 Kim J. M. 5191546 547 Kirtany J. K. 4751119 Kawauchi H. 3331214 Khan I. A. 5211682 6791219 Kim J.-P. 618125 Kiryu M. 3001405 Kawazoe K. 463175 Khan J. A, 218160 61 63 Kim J. S. 731166 Kise N. 721118 Kawka S. 474119 Khan K. 6361122 Kim K. K. 1431216 Kishi M. P. 981188 Kayano Y. 405112 Khan K.M. 383121 Kim K. S. 5201641 Kishi T. 450181 82 Kayser F. 383111 Khan M. 1841443 Kim L. J. 3851188 Kishi Y. 203150 462115 463135 36 Kayser O. 475188 Khan M. N. 4081233 Kim M. G. 5901138 139 41 46 Kazakhova E. K. 5171381 Khan M. W. Y. 1831407 Kim M. R. 1851560 Kishida E. 1841516 Kazeminski M. 5171390 Khan N. 1811200 Kim M. S. 217117 218127 Kishida M. 741253 Kaziro Y. 109137 Khan R. M. A. 82123 Kim N. J. 4071122 Kishikawa E. 20123 Kazlauskas R. 2971121 128 Khanm K. M. 383120 Kim S. 3011471 3851210 214 Kishikawa K. 4081282 Kazlov N. G. 5211673 Khanna R. K. 5141110 5201598 Kishimoto J. 3581242 Kearns P. S. 3011454 428186 Khanna R. N. 4751114 Kim S. K. 4071122 Kishioka S. 4101370 Keating M. 41 11460 Khare M. K. 6791233 Kim S.-K. 9140. 41. 42 43 59 62 Kishiro K.I861682 Keeler R. F. 203125 53 Kharkwal H. 5141102 5151192 10192 Kisic A. 3851188 Kehagia K. 3861241 Khatoon R. 1611223 Kim S.-O. 1421104 Kisiel W. 1601200 1621301 Kehr J. 4091353 Khaw L. E. 450120 45 46 Kim S. U. 1421103 5171365 Kisor D. F. 406145 Kehrer J. P. 451191 141 Khien P. V. 5141128 60311 03 Kita I. 5181444 Keith D. D. 3311114 Khilevich A, 475172 Kim S. W. 2561131 2561132 372152 Kita Y. 46219 514175 5171391 Kelecom A. 1621344 3001338 Khodair A. I. 5161250 Kim S. Y. 4071157 Kitabayashi M. 6791215 Keller E. 5 181409 Khodakov G. V. 6781167 168 Kim T. S. 1611255 296145 296146 Kitagawa I. 29711 70 2981181 182 Keller G. 6031110 Khoi T. T. 5141134 Kim W.-G. 618125 205 230 463175 51 71311 347 Keller N. P. 5561166 167 Khokhar I. 82119 Kim Y. 401142 356134 3571158 5 191488 5561154 Keller P.J. 450122 4511151 553115 Khosla C. 55314 6 554125 26 27 Kim Y.-G. 731128 Kitagawa S. 650123 Keller R. K. 602174 28 29 32 555175 Kim Y. H. 731166 2561117 Kitahara M. 4511172 Keller W. J. 40/109 Khripach V. A. 3851195 196 202 4081272 Kitahara T. 46219 Keller-Schierlein,W. 4511140 169 Khuong-Huu F. 25711 72 Kimbara N. 5 17/385 Kitahata L. M. 4081282 170 Kiang Y. Z. 5201612 Kimmins F. M. 971105 Kitajima M. 522/762 58814 15 27 Kellett M. 331173 Kibayashi C. 20136 39130 70 Kimpe N. D. 475195 31 Kellner R. L. L. 96124 40184 93 405120 61 8144 45 46 Kimura A. 3851156 Kitamura M. 5161298 5201618 Kellogg R. M.. 71135 40516 63412 63 5/61 62 Kimura M . 406169 4081225 Kitanaka K. 2981230 Kelly M. T. 463124 5561151 Kibby J. J.451199 100. 103 Kimura N. 72196 Kitano K. 331152 Kelly N. M. 218118 19 67 Kida I. 158115 Kimura S. 3331214 Kitazume T. 218185 Kelly W. 3321195 Kiddle G. A. 97176 77 Kimura T. 1621329 255161 296139 Kitching W. 5 181452 Kelly-Borges M. 159149 1841454 Kiddle J. J. 39111 40181 428141 Kite G. C. 971129 971131 635122 2971160 161 Kido M. 2981230 Kimura T. 5181405 36 2981190 206. 248 2991260 428192 Kido T. 5171361 Kimura Y. 428160 5561180 Kito M. 1871802 94 Kieser T. 5551116 Kindl H. 981171 5561198 Kitsuwa T. 9127 30 Kelstrup E. 36/23 Kiessling L. L. 5561130 King A. 159148 2991249 Kittakoop P. 6511121 Kem W. R. 3011347 Kiewitt I. 1881835 862 864 865 King A. G. 6361133 Kitteringham J. 5901131 Kempe R. 5201655 Kifayatullah M. 1871716 King A. O. 1831425 Kittur M. H.1811154 Kemper F. H.. 4071175 Kigawa M. 5211741 King C.-H. R. 635134 Kiuchi F. 41 11458 Kemper K. 1861622 Kigoshi H. 2971151 3001403 King M. L. 1611249 Kivcak B. 741228 303110 I1 Index of authors cited 1-47 Kiviranta J. L. J. 5161281 Kobayashi J. 158124 159147 Kivirikko K. I. 3321187 1841447 2571158. 159 296125 61 Kiyono H. 3851194 76 2971146 2911149 158 162 Kiyosawa S. 981190 163 2981189 202 236 237 Kiyota N. 1441249 2991251 252 294 304 314 Kiyotani T. 6791215 3011431 432 3571117 428174 Kizawa Y.,5561191 195 463152 79 103 5561139 Kizito S. A. 38318 Kobayashi K. 131198 2981176 Kizu H. 3001389 390 6511112 45211 92 5 14/75 6031103 6781151 Kobayashi M. 731173 209 1441221 Klaebe A. 981156 231 180l102 24 1191 2421107 114 Klages A.L. 356143 129 130 131 160 161 2571210 Klee H. J. 10179 2911170 2981181 182 205 230 Kleiman R. 1821265 1881824 854 2991294 3001360 37 1133 38313 859 463175 5561154 Klein D.. 296154 462116 Kobayashi N. 1851587 Klein F. K. 81111 Kobayashi S. 109178 1861700 Klein H. 3581213 303115 Klein L. L. 109191 2571174 Kobayashi T. 463133 415182 Klein R. A, 3851168 Kobayashi Y. 1821315 Klein S. 6361120 Kobe J. 1841496 Kleinig H. 602126 65 6031106 107 Kobek K. 3571138 5891117 114 I23 Kobyashi H. 650/24 Klicka K. D. 5171341 342 Kobyashi J. 65018 22 24 651170 Klima J. 1851610 72 73 74 Kling M. R. 1821298 Koch. B. 372164 Klingstedt T. 1821279 Koch B. M. 312165 Klinotova E. 38511 71 Koch K. 450149 Klir P. 1851610 Koch M. 20113 82136 611111 Klix H. 2981187 6 18/74 Klockars G.K. 971119 Kocienski P. 2991305 5201639 Klohr S. E. 5561129 2991306 6361102 Klopfenstein W. E. 1891899 Kodaira A. 159140 3511164 Kodama K. 1811150 Kluepfel D. 450184 Kodama M. 1591111 463149 Kluge H. 651168 Kodama O. 981190 192 193 Kluge S. 1601150 1431206 Klumpp G. W. 5211665 Kodama Y. 5171373 Klute W. 6361119 Kodera N. 6791214 Klutz B. W. 4091350 Kodoma M. 3001365 676133 36 Klyne W. 240116 Koehn F. 462111 Klyuev N. A. 4071155 Koenig M. 5221783 Knani M. 142155 602146 Koepke T. 513131 5181454 Knapp Jr. F. F. 1841460 Koepp A. 1441251 Knapp R. J. 4101423 Koepp A. E. 142197 102 1431198 Knauer B. 384165 Koga J. 255176 Knauf V. C. 356164 Koga N. 3581242 Kneifel H. 255132 Koga Y. 2971107 Knez Z. 1881845 Koh D.1621320 Knight B. 401142 Koh H. F. 1871711 Knight D. W. 401143 Koh H. S. 971106 Knizhnikov V. A, 5211673 Kohda H. 58818 Knoch F. 25711 71 Kohlmiinzer S. 1601200 Knoche H. W. 356175 Kohlwein S. D.. 3511141 Knolker H.-J. 296157 427112 13 14 Kohn G. 1811186 3511155 Knopf F. C. 1601202 Kohout L. 3851166 Knopp B. 659131 Kohsaka M. 450139 Knops L. 2581238 Kohyo Y. 4071192 Knothe G. 1821304 305 1871742 Koide K. 1881882 4081242 428165 1891894 671194 6781169 Knowles D. J. C. 3311116 Koike Y.,401111 Knowles J. R. 3321132 137 138 Koiso Y. 2571158 450165 139 4511119 I20 Koivistoinen P. E. 1851524 Knox J. R. 241138 2431192 3321141 Koiwai A. 1811229 Knudsen A. D. 6781192 Koizumi. C. 1871778 Knudsen J. T. 971136 Koizumi T. 5 181429 5201634 652 Knudsen L.T. 971134 Kojima A. 428160 Knudsen T. B. 1421119 Kojima F. 296129 Knudson J. 3581228 Kojima M. 1811231 Knuhl G. 158132 Kojima R. 1441249 Knutsson P. G. 91158 Kojima T. 1851521 KO D.-H. 3851148 Kojo S. 1841516 KO F. N. 4071177 189 428145 Kokke W. C. 1841446 2981207 414124 42 Kokki H. 4081277 KO F.-N. 11142 618134 52 Kokpol U. 971100 KO K. M. 72151 Kokubun T. 981161 162 175 176 KO K-Y. 5181433 177 KO S.-B. 5891128 5901129 Kokzhaleva B. Z. 636195 KO S. H. 5191499 500 501 Kol O. 6181158 KO S. Y. 650138 Kolasin T. 4081241 253 Koarai T. 9136 Kolattukudy P. E. 356174 83 84 Koba S. 9140 3511106 3581231 232 Kobaru S. 555160 Kolbe A. 10199 101 102 Kobasyashi J. 159146 Kolczewski S. 401150 636197 Kobata K. I601163 Kolehmainen E.5201659 Kobayashi E. 4291123 125 4291125 Kolehmainen E. T. 3851160 Kobayashi G. S. 109196 Kolehmainen J. 911114 Kobayashi H. 2981202 474118 31 Kolemainen E. 5191529 564 32 5561128 Kolisis F. N. 1881839 1-68 Natural Product Reports 1997 Koljak R. 3571129 Kollar L. 384146 47 48 Kollenz G. 356155 Koller C. 41 11460 Kolodziej H. 475188 Kolodziej P. A. 3581249 Kolodziejczyk K. 255117 18 Kolpak M. X. 4521188 5561150 Koltun D. O. 1601159 Komagata K. 450155 Komai K. 5211722 Komatsu H. 109168 Komatsu Y. 6791212 Komatsuzaki N. 5181420 Kombrink E. 981160 Komiyama K. 3001389 390 449111 12 450113. 4511167 589179 Komiyama N. 555163 Komoda A. 384160 Komoda Y. 450179 80 Komori T. 255161 3011472 331150 Komoriya S. 406140 Konaklieva M.1811167 Konat R. K. 2981198 Konatchiev A. N. 5151161 Koncz C. 10198 Koncz-Kalman Z. 10198 Kondo E. 331155 Kondo F. 384149 Kondo H. 356126 Kondo J. 1851587 Kondo K. 72147 131206 1611216 Kondo M. 463190 5221809 Kondo N. 6111113 114 Kondo S. 3331214 5211740 Kondo T. 1811231 296167 3001405 Kondo Y. 4291128 Kondoh K. 4631103 Kondoh T. 1601151 Kondratenko A. E. 6781156 Kondrat’ev P. N. 5201608 Kone K. G. 5211711 Kong F. 2981180 2981196 204 428148 Kong L. Y. 414144 45 46 Kong M. 2571162 Kong W. A. 356162 Kong Y.C. 72151 Kongsaeree P. 5181485 Konig W. A, 331176 Konig A, 450120 45 46 Konig G. M. 1591119 291191 119 120 2991292 4281104 Konig W. A. 1601147 1611218 1621342 450166 Koning G.M. 42112~ Konings A. W. T. 71135 Konishi H. 731198 Konishi K. 4631107 Konishi M. 5561128 Konkoy C. S. 4081209 Konno C. 731140 Konno H. 635137 Konno K. 384149 Kono M. 421123 Kono Y. 981194 Konoshima T. 5211676 Konosu S. 463153 Kontani T. 5201634 Konuklugil B. 71/33 Konukol S. 303122 Koomans H. A. 4101386 Koomen G. J. 5171351 6511101 Koornneef M. 2421155 Kopitzka R. W. 2581234 2991283 Kopycki W. J. 71/11 Koraleva V. 981169 Korchagina D. V. 1591109 514177 5161305 5111383 5211712 Kordragina D. V. 5191574 Koreeda M. 3851201 Korenaga T. 142173 1431136 137 138 3851193 Koritala. S. 1891892 893 Kormachev V. V. 5191517 Kornprobst J. M. 1811176 179 180 196 197 216 Korth J.. 1841509 Korth K.L. 141136 602127 Korvola J. 5191529 52016.59 Korzun B. P. 588111 Kosaka T. 1621328 2981236 Kosaka Y. 10191 9141 4071158 Koseki K. 513116 Kosela S. 6791207 Koser S. 5191516 519 Koshimizu K. 72/57 741240 981187 158137 241173 5221809 Koshimura H. 1611208 Koshino H. 5211689 Koshioka M. 1441230 2561140 Koshioka N. 2421147 Koskinen A. M. P. 401107 5191504 Kosmeijer-Schuil T. G. 2561116 Kosten T. A. 4101374 Kostenyuk I. 58814 Koster W. H. 331153 Kostova I. 5221758 Kostova K. 5201581 590 Kosuge S. 2981202 650124 Kosuge T. 3011428 Kosuge Y. 1851580 Kosugi H. 1851521 Kosugi Y. 1881838 Kotake K. I. 415162 Kotarski S. F. 3917 Kothari P. 41 1/446 Koths K. E. 356175 Kotian P. L. 650141 Kotsuki H.427120 Kottayil S. 4101390 Kotthaus M. 401152 Kotting J. 1881858 Kotzias D. 514160 Kou X. 1611276 Koudate T. 218172 Koudou J. 5 161261 Koumaglo K. H. 5151141 Koumura N. 296175 Kouno I. I311 73 141248 5211733 617196 Kouroupis P. 4101443 41 11445 Kova B. 5191568 Kovacs I. 39132 45 Koval’skaya S. S. 5201576 5211673 Kovchagina D. F. 5211711 Kover W. B. 5171382 Kovtun G. A, 5171387 Kowal C. 553115 Kowalski J. 602193 Kowalski P. 47418 Koyama A. 58818 Koyama H. 159168 1621348 Koyama K. 6771113 114 Koyama T. 142159 60 61 72 1431136 137 138 139 15815 602136 83 85 95 6031104 Koyama Y. 450136 Koyamatsu T. 1821266 Koyano T. 589179 Koyuncu M. 5 15/21 9 5 161249 251 Koza T. 1851612 Kozai Y.,450181 Kozaka Y.4091307 Kozarich J. W. 109155 64 76 Kozbar E. A, 5211711 Kozikowski A. P. 651184 Koziol B. 401132 133 134 135 Kozler M. V. 96139 Kozlov N. G. 5201576 Kozlovsky A. G. 2011 7 Kozlowski J. F. 356152 Kozuka M. 5211676 Krach K. M. 9811 70 Kraeutler B. 5 171308 Kraft-Klaunzer P. 2561145 Kragl U. 218122 Krajnc E. I. 4091309 Krajnc-Franken M. A. M. 4091309 Kramer R. A. 4641113 Kramer. T. H. 4091289 Kramer U. 96145 Krasokhin V. B. 2991324 Krassnig R. 4081239 Kraus G. A, 5181463 Kraus P. F. X. 371123 Kraus R. 1811224 Kulanthaivel P. 3001380 Kusaka T. 1871775 356178 79 80 Lai S. 20213 Krause E.. 9811 71 Kulbelka W. 1611259 Kusano A. 676135 Laihia K. 5191529 564 5201659 Krause H. 428173 Kulesh N.I. 741269 Kusano G. 650123 35 Laine C. 588122 23 Krauss G. 101101 Kuleva L. V. 514184 Kushida K. 296140 Laine M. 141145 6031136 Kravtchenko D. 474138 Kulikova L. E. 3851153 Kushiyama E. 4081242 Laing W. A. 97183 Krawiec M. 255168 Kulkarni B. A, 1811204 1821280 Kushwaha R. K. S. 514170 LaIuppa J. C. 218725 2191102 Krebs B. 1611262 285 Kiismenoglu $. 659128 Lajide L. 721124 971101 255146 Krebs H. C. 255132 Kulkarni D. G. 5211666 Kusono A, 676134 2561115 Kreh M. 30312. 17. I9 Kulkarni M. S. 474133 475157 Kusono G. 676134 Lajis N. H. 4081233 Kreifels S. 1851542 Kulkarni R. H. 5151185 Kustrak D. 5161255 5221805 Lajoie G. A. 218187 Kreis P. 513129 Kulkarni S. A, 474133 Kusumi T. 1811203 2981209 LaJunen M. 5191504. 5201658 Kreisberg-Zakarin R. 2431191 Kul'kova N.V. 5171396 3011474 Lakin E. E. 5181436 Kreishman G. P. 1871718 Kullenberg B. 971132 Kutcha R. D. 3331205 Lakshmaiah G. 3841119 Krempp E. 6781197 Kulothungan C. 650150 Kutchan T. M. 37118 23 27 34 Lakshmanan A. J. 659134 35 Kren. V.. 428184 85 Kulshreshtha D. K. 677199 Kutney J. P. 5211681 Lakshmi V. 2991255 Krepps B.. 475170 71 Kumabe M. 676145 Kutulya L. A. 5181436 Lakshmikantham M. V. 2981213 Kretzschmar G. 10815 Kumagai H. 555167 Kuwada T. 3011461 462 427118 Lakshminarayana G.. 1811154 Kreuz K. 602165 6031123 Kumagai K. 109172 Kuwahara J. 201.56 1821302 324 1831345 1841495 Kricke P. 651168 Kumar D. 20120 731186 Kuwahara Y. 660147 508 1861674 1881816 Krief A, 5171333 335 Kumar G. J. 6771100 Kuwajima H. 5221755 756 Lal A. R. 2991298 Kriegel J. 405118 Kumar K.R. 3001343 Kuwano H. 296137 4631100 Lal M. 475158 Krinsky N. I.. 1441250 Kumar N. V. 2981207 Kuziora M. A. 3571144 Lallem J-Y. 5181417 5211706 Krisans S. K.. 6031110 Kumar R. 731125 1601136 589148 Kuzma J. 142152 55611 90 Krischke W. 450157 68 Kumar R. A. 109162 70 Kuzmina N. A, 218179 Lallemand J. Y. 3581198 6511115 Krishna M. M. 2571210 3001360 Kumar S. 1621305 3581229 230 Kuznetsov V. P. 5181436 116 Krishna P. 10183 Kumar V. 1601198 1621331 384162 Kuznetsova 0.B. 218123 Lam. C. C.. 1871735 736 737 738 Krishna P. R.. 1821325 42716 475167 Kuznetsova T.. 4641110 739 740 742 Krishnaiah D. 1841500 Kumarathasan R. 1801131 Kuznetsova T. A. 296131 Lam C. K. 1831398 Krishnakumari B. 5 171336 Kumaresan S. 3841119 Kwak S. S. 1441227 228 2421110. Lam H. P.303113 Krishnamurthy. G. 4641113 Kumari G. N. K. 97195 677167 Ill 114 2571169 372152 Lam K. S. 428193 5561129 Krishna Murthy M. V. R. 2571225 Kumeda Y. 296142 428163 618158 Kwak Y. S. 513114 Lam S. 372163 4521184 Krishnan B. 109164 5561129 Kiindig E. P. 6361122 Kwan C. Y. 406191 Lam W. K. 1841455 Krishnan B. J.. 109155 Kundsen J. T. 971126 138 Kwoczak R. 1851584 Lam W. L. K. 1831346 Krishnan B. S.. 428193 Kundu A. B. 1601188 6781127 226 Kwon B.-M. 2991312 Lam Y. 450133 34 Krishnan G. 589171 Kunhara M. 15816 Kwon M.-A, 401142 Lamarque A. L. 5161238 Krishnasamy V. 5 191573 Kunieda T. 5201629 Kwon 0.O. 5191546 547 Lamarti A. 1431131 132 133 Krishnaswamy N. R.. 1601191 Kunigami T. 42717 Kwon T. 3851147 513146 47 48 Krock K. A, 513126 Kunisch F. 1101105 Ky P.T.. 58819 Lamaty G. 514186 5151152 205 Kroese H. W.. 971127 Kunitomo J. 20155 Kyle D. J. 463187 212 5161234 261 Krohn K.. 384165 Kuntz M. 142181 Kyogoku Y. 2981230 Lamaty G. E. 5151150 Krol W. J. 3321171 172 177 184 Kunze A. 96153 Kyokawa Y. 9119 20 Lamazouere A-M. 5 191532 Krone. B. 331174 Kunze B. 617120 Kyossev Z. N. 39148 Lamb B. K. 514158 Kroon J. 383129 Kuo C. L. 4071124 Kyosseva S. V. 39148 Lamb C. J. 141131 Kroon P. A,. 142179 6031135 137 Kuo L. H. 5181431 Kyouda M. 514174 5171378 Lamb P. B. 4081244 Kroszczynski W. 383123 KUO L.-M. Y. 650127 Kyratzis I.. 5171356 Lambardini J. 40711 73 Kroumova A. B. 35517 KUO,S.-C. 2016 29 Kysilka R. 1851612 Lamberson C. R. 1431148 Krstic. N. 384181 Kuo Y. 1611249 Lamberti P. 4081205 Krueger. C.. 5 17/31 9 5201582 Kuo Y.H. 731152 1611249 650126 Lamboley S. 2981171 Krueger. G. G.. 4101396 27 6791208 Lambropoulos J. 40711 91 L Krug P. J. 158125 3001414 Kuoh C.-S. 618153 73 Lame M. W. 660164 Kruggel F. I101105 Kuono I. 5221777 Lamidi M. 6791234 Kruk. C. 303122 Kupchan S. M. 450179 80 Laakso P. 1861629 640 647 659 Lamont R. B. 255122 Krull R. E. 5221782 Kurahashi K. 372190 660 Lamparczyk H. 47418 Krupadanam. G. L. D. 475199 Kuraishi S. 10173 Laatsch H. 731205 296130. 428159 Lampe J. 71/17 Krush A, 5161256 Kuramoto M. 296132 463126 462118 Lampe J. W. 71137 39 Ksebati M. B. 3011442 6361128 129 Labarre S. 82136 Lampel J. S. 555147 Ku Y. 1851526 Kuramshin R. A, 1851561 Labaudiniere R. 1841471 Lampi A. M. 1851524 Kubanek J. 3011433. 618122 Kurano N. 463183 4641109 Labbe C.5171346 Lampman R. L. 971130 Kubelka W.. 1621309 5171328 Kurantz M. J. 1851584 Labelle M. 1821293 Lan T. 4071134 Kubicki M.. 401140 635186 Kurasawa S. 462/7 Labeque R. 1851536 Lancaster J. E. 450183 Kubo A, 298121 9 Kurata T. 514175 5171391 La Bora D. 4101434 Lancini G. 450185 Kubo H. 401141 Kurcuoglu M. 51 71353 Laboret F. 2561134 Lancini G. C. 450184 Kubo I. 1591115 Kurek-Tyrlik A. 2991321 3851208 Laboute P. 65015 Kubo T. 5181428 Kurihara H. 384198 Labrecque J. 1441243 247 Landais Y. 72172 Kubo Y. 1591115 5161295 Kurihara M. 142170 71 588131 Labrie F. 3841114 127 128 130 Landman O. 2431191 Kubota M. 5201653 Kurihara T. 428141 65913 I3I Landmesser N. G. 635134 Kubota T. 255173 Kuriki T. 2991264 5561154 Lacailte-Dubois M.-A. 6791201 Landolt P. J. 96136 Kubota Y.5181430 Kurkcuoglu M. 5 151198 Lacave C. S. 356193 95 96 99 Lane S. J. 5561174 Kuc J. A, 6031129 Kurkjian R. 4751105 Lachance P. A, 141118 Laneelle G. 356193 95 96 Kucera R. 463131 Kuroda A. 450138 40 5551100 Lackey K. 5901137 Laneelle M.-A. 356186 93 95 Kucherenko A. 475172 Kuroda H. 71/13 72155 La Clair J. J. 1601158 Laney M. 2981241 428190 Kuck N. 109156 Kuroda S. 6361121 Lacroix A. 1441243 247 Lanfranchi G. 5 161289 Kudelski A. 450141 Kuroda T. 72/47 731206 2561131 Lacroute F. 142162 Lang R. W. 2991317 Kudo. K. 5171314 Kuroda Y. 2561124 Ladam P. 109194 95 Lsng S. S. 141145 6031136 Kuehn H. 1821245 Kuronen P. 3011425 Ladeveze V. 602190 Lange G. L. I621296 Kuehne M. E.. 589164 65 89 105 Kurosaki. F. 5561191 192 193 194 Ladisch M. R. 372181 Lange 0.L. 96119 97161 Kuenzer H. 384196 102 195 Ladwa P. H. 5181438 Lange T. 14111 1441222 223 224 Kueppers H. 5 I71338 Kurosawa E. 297192 Laessoe T. 1821240 226 232 233 Kuftinec J. 5161255 Kurosawa H. 2971103 LaFever R. E. 1421100 1431198 Lange U. 159166 Kuhn P. J. 6031125 Kurosawa T. 3851156 I92 208 4511162 Kuhn P.. 39166 Kurose N. 5 181429 5201652 Lafont R. 3851204 Langebartels R. 9811 71 Lagarde M. 1801137 Langenheim J. H. 9618 971142 Kuhnl K.. 21719 Kurosu M. 2981182 60 113 Lagarias J. C. 81111 18 Langford M. 10182 Kuhnt C.. 9/25 Kurowska A, 5221768 Lage M. 1611262 Kuhnt M. 731185 Kuroyanagi M. 6781131 173 Lagneau N. 635131 Langholz P. I881809 Kukhar V. P.. 218179 Kurth C. D. 4091340 Lahlou E. 9811 78 Langley D. R. 109163. 1101109 Kuklev D.V.. 181l160 174 1861672 Kurtz H. A. 296131 Lahloub M. F. 474120 5221802 Langley P. F. 331162 63 Kukovinets 0.S. 5161304 Kurucu S. 5151219 Lai J.-Y..462114 Langlois N. 5201624 Kuksis A. 180179 114 1861668 Kurz J. 4511148 Lai M. C. 5201609 Langlois Y. 428175 520162.5 Kula J. 5191.537 Kurzer M. S. 71137 38 Lai R. 5191533 Langrand G. 1881885 Index of authors cited Lankiewicz L. 2 18138 2 1911 I0 Lankin D. C. 72195 Lansbury P. T. 1601158 Lanser A. C. 1861691 1891891 895 899 Lanza A. M. D. 1611271 Lanzetta R. 981153 154 5161271 Lanzotti V. 1811207 2991307 Lao A.-N.,203133 Lao H. B. 1831393 1861702 Laorden M.L. 4091300 Laplace G. 635133 Laplante S. 3841130 Lappalainen K. V. 3851160 Lara A. 1621349 5151167 Larcheveque M.3851204 Laronze J.-Y. 428131 588132 Larsen L. K. 553111 555190 Larsen R. M. 1841451 3571127 Larson D. L. 4081247 Larson S. M. 4111446 Larsson K. 180146 Lartey P. A. 109191 Laschat S. 5 171318 319 Lason W. 4091352 Lassaba E. 1601142 Lassak E. V. 5141114 5151142 Lassota P. 4641113 Last R. L. 981174 Lastra E. 218173 Lathbury D. 40185 63414 Latvala A. 303110 I1 Latypov S. K. 1851561 Latyshev A. S. 1861672 Latyshev N. A. 1811160 174 178 Lau C. K. 5221811 Lau R. C. M. 372189 4511153 Lau S.-M. C. 1421113 Laudora V. 91191 Laue E. D. 555191 124 125 Laumen K. 1881846 Launay J. M. 4101411 Laurent E. 4101397 Laurent R. 5151167 192 243 Laurent S. J. 5151151 Laus G. 588130 Lausch R. 1881839 Lauterwein J.5171318 Laux T. 3581212 Lavaud C. 61111 677190 Lavayre J. 2981223 2991266 Lavidis N. A. 4091326 327 Lavilla R. 428144 Lavin M. F. 3011443 Law J. H. 356181 Lawlor E. J. 3321166 168 312171 Lawrence B. M. 5151218 5161254 Lawrence C. C. 2191114 3321188 Lawrence C. M. 141137 Lawson A. M. 356188 Lawson D. M. 971120 Lawson M. P. 1811194 Lay Y.-Y. 39/74 Laya-Mimo M. 1611238 Laydoo R. S. 3001361 Layer H. 82/44 Lazar D. 383128 Lazar G. 4511140 Lazar L. 2911114 Lazaro A. 589148 Lazaro R. 33211 75 Lazarus C. M. 2421116 Lazny R. 6511107 108 Leach D. N. 5171356 Leadbetter E. R. 356120 Leadlay P. F. 356132 76 3571107 108 109 110 3581221 55315 555168 69 70 74 113 119 120 121 Leadley P. F. 450120 45 46 48 51 Leal W.S. 96132 34 Lebada R. 659131 Le Bail M. 39167 635153 Le Bars D. 1841489 Lebedev M. Y. 5161294 LeBel N. A. 74/2-50 520f603 Le Berre F. 1821318 Lebl M. 3851166 Leboyer M. 410l411 5161257 Lebrun A. 72/72 Lebrun S. 650116 Leclaire M. 5211706 Leclercq P. A. 514188 89 90 116 117 122 125 126 127 128 132 134 139 5151187 237 5161237 LeCloux D. D. 5181442 Ledent P. 330129 Ledermann A. 428195 Ledon H. 1881812 Lee A. Y. 2971113 Lee C. 6 18/64 Lee C. K. 256185 Lee C.-O. 2971168 Lee D. S. 5201609 612 Lee D. W. 618159 Lee E. 72197 3001396 5211734 635143 52 Lee E. Y. 356168 Lee G. P. 6361116 Lee H. 731128 133 141244 Lee H. J. 1421103 104 3851147 148 5111365 Lee H. L. 1831368 Lee I.Q. 1851541 542 Lee I. S. 255122 61613 Lee J. C. 2571230 Lee J. E. 1101109 Lee J. H. 411159 Lee J. J. 2561117 553115 Lee J. P. 4511106 151 5561133 Lee J. Y. 5201643 Lee K. 40518 Lee K. H. 1611249 5221759 Lee K. J.-H. 11127 Lee K. K. 3011451 5901138 139 Lee K. Y. 1621355 Lee K.-H. 71/27 28 29 30 31 44 741246 6 18/25 650126 27 677170 92 93 6791208 Lee K.-M. 2191108 Lee K.-Y. 2991273 Lee M. 42714 Lee M. D. 109156 Lee M. H. 1861692 Lee M. K. 4071133 Lee M. S. 428193 4521190 5561148 Lee N. C. 659115 Lee N. M. 4091334 Lee S. 401154 4511155 5201630 6361105 Lee S. E. 1101109 5551111 Lee S. G. 5191494 Lee S. H. 1591101 Lee S. J. 4011125 Lee S. K. 6791205 Lee S. S. 405134 4061104 105 Lee S. S. C.1881847 Lee S. W. 2561117 4071125 Lee S.-L. 3581243 Lee S.-S. 731182 82133 Lee T. D. 96140 Lee T. W. 1861661 Lee V. 3331212 Lee V. E. 3311118 Lee Y. R. 474140 Lee Y. W. 4081268 Leenders R. G. G. 109134 Leeper F. J. 39141 555191 124 Lees L. J. 3311109 Leeson P. D. 218130 31 Leet J. E. 2981195 428193 Leete E. 37119 LeFevre J. W. 4521188 5561150 Le Gall T. 1821331 Leger J. M. 255143 Le Gouill C. 555148 Legoy M. D. 1881883 Legr A.-M. 463142 Le Guen V. 5181468 Lei J. 6781136 Lei S. 406190 Leibfritz D. 401138 635189 Leighton B. N. 405126 Leinonen A, 3851133 Leiser A. 5551117 Leisinger K. F. 1831369 Leistner E. 4511116 138 139 Leitao Filho H. F. 58816 Leitich J. 450184 Leitinger B. 356155 Leitner P.L. 5901137 Lellouche J. P. 1841483 484 Lemaire C. 219198 Lemaire J. 5201586 LeMaster D. M. 211117 218124 25 27 2 191102 Le MBnez P. 6361101 Le Men-Olivier L. 20112 82126 47 4061109 58813 Le Merrer Y. 180196 Lemiere G. 741252 Lemieux R. U. 10811 4521193 Lemmich E. 6181192 Lemmich J. 474136 5191557 Lemos T. L. G. 589197 Lenain V. 12172 Lennon I. C. 5551120 121 122 123 Lenton J. R. 2431202 2561114 Lenz R. 371128 29 30 Leon C. 971131 Leonard A. 2981212 Leoncini G. 4751115 Leone D. 651185 Le Page-Degivry M.-T. 1431186 le Peletier F. 5161301 Lepingle A. 651l111 Lepoivre J. 741252 LeQuesne P. W. 65013 Le Quere J. L. 1831354 1861636 Leri G. 5211702 Leriverend C. 5201596 Lerner A. 3321141 Leroy Y.6181158 197 Lerpiniere J. 650138 Lesburg C. A, 1431149 Leskiw B. K. 331186 Leskova G. V. 4101438 Leslie M. G. 1831403 Lesma E. 4091341 Lesma G. 589181 91 Lessinger L. 3001382 Lessire R. 1801147 3511171 Lester J. B. 450120 Letavic M. A. 741254 255 2991286 Letourneux Y. 3851182 Lett R. M. 40186 Leu S.-L. I41246 Leu Y.-L. 12/67 5891127 617119 Leung D. W. Y. 1821281 1831393 Leung M. K. 4091314 Leuschner C. 602149 Lever J. R. 4081248 Levet R. 5211706 Levi C. 1811179 Levin R. I. 4111452 Levina I. S. 3851153 154 Levine L. 463133 Levington J. S. 46213 Levisalles J. 384164 Levkovich M. G. 405113 22 23 31 406155 60 63 111 Levy E. J. 1861656 Levy J. 588132 Levy-Frebault V. V. 356187 Lew F.T. 241156 Lewer P. 2431130 Lewin A. H. 303123 4081243 244 Lewin G. 589182 84 635176 Lewinsohn E. 142191 92 1431210 514163 5161274 Lewinsohn W. 513149 Lewis B. A. 96150 Lewis J. R. 303121 30315 Lewis J. W. 4081230 231 4101416 Lewis M. I. 2421106 1.59 I64 Lewis N. G. 7113 4 72/54 1431197 198 1441251 252 Lewis N. J. 5191535 Lewis P. A. 650154 67614 Lewis R. N. A. H. 450159 Ley S. V. 5551119 120 121 122 123 677183 Leysen J. E. 4091328 355 Leza J. C. 4091363 Lhommet G. 39167 68 635153 54 57 Li B. 2571156 Li C. 3011434 Li C. J. 676138 Li D. 1611276 406186 4071128 589180 6771109 6781196 Li D. G. 406181 Li E. 2581240 Li F. 406190 Li G.-Y. 427124 Li H. 1841453 2971137 2981200 299131 7 384143 4071134 4081217 5151149 162 555179 Li H-Y 218172 5891103 Li J.401113 10197 42113 514159 5 181415 6781155 Li J. X. 203143 616137 Li K. 4111461 Li K. S. 635143 Li L. 131210 211 1441225 2421121 123 2571174 Li L. N. 141215 299131 7 677152 63 Li N. 3841122 Li P. 40519 Li Q. 731195 4061118 Li R. 1831423 424 3511126 Li R. M. 2561120 Li S. 384143 408121 2 Li S.-J. 356125 Li T. 109168 1611245 406190 5181470 Li W. S. 1601199 Li X. 141215 3001384 3841127 128 130 131 406180 4071135 4101423 474144 45 46 5 141124 5 151183 5 111345 5221765 616146 Li X.-C. 6181132 Li X. F. 406189 Li X. Y. 4091320 Li Y. 1431171 192 1611245 1841447 2971158 3001351 414144 45 5181470 5191513 521 5201613 65915 Li Y. C. 1611254 Li Y.H. 616138 Li Z. 203139 384167 4081258 Lia Z. J. 1611234 Liang F. 5201598 Liang G. Y. 6111107 Liang J. 5561200 Liang J. H. 1861651 Liang L. 6781164 165 Liang T.-C. 555173 Liang X. 2571188 189 Liang X. T. 2511162 167 6781189 190 Liao C.-C. 588135 Liao J.-F. 428146 618154 Liao Y. 428177 Liard M. C. 5211739 Liaw C.-C. 296180 Liaw Y. C. 109119 20 Liberra K. 296116 Libert V. 218177 Librando V. 65917 Lichtental H. K. 241151 Lichtenthaler H. K. 3571138 156 Lichter W. 6791227 Liddell J. R. 65919 25 26 27 42 660160 61 Lidert Z. 635147 Lidstroem P. J. 3841126 Lie Ken Jie M. S. F. 180199 1811165 1821281 287 1831346 347 364 365 384 385 386 387 393 395 397 398 399 400 401 406 408 409 1841429 436 437 438 439 440 441 1861669 701 702 703 704 70.5 1871720 721 735 736 737 738 739 740 741 742 763 764,765 766 767 800 803 1891906 Liebergeshell M.356169 70 Lieberknecht A. 8 111 Liebson I. R. 4101435 Liedl B. E. 911120 Liedvogel B. 602118 6031107 Lien C. A, 40614.5 Lienard P. 741227 Lienhart A. 406153 Liesch J. M. 1591101 256177 1-70 Natural Product Reports I997 Light D. M. 96/37 Lithgow A. N. 159158 Loidl-Stahlhofen A. 1851538 539 Lu Z. Z. 731140 Liguori T. 410141.5 Little C. H. A. 9/59 Loike J. D. 72/92 Lua L. 4091337 Lill R. E. 372194 Little D. B. 1421106 Lond F. 40514 Lubo A. M. 428172 Lillard? D. A, 1881817 Little P. D. 5181425 Long B. H. 109169 2571184 189 Lucaccioni F. 513124 Lille U. 3571129 Littler B.J. 651166 Long D. R. 6031141 Lucarain L. 3011476 Lilley R. 96/31 Litvinovskaya R.P. 3851195 196 Long K. 2571209 3001357 Lucas M. J. 1601174 Lim A. 5201630 Liu A. 2981185 Longhrin J. 97185 Luczak L. 5181406 Lim C. K. 71112 Liu B. N. 1871748 749 750 751 Longley R. E. 2981175 462111 Lucke S. 3571151 Lim C. L. 4081210 759 Longley R. P. 4521182 Ludovic M. 3321192 Lim H.-J. 6361126 Liu C. 401154 109168 451l111 Lontsi D. 6181126 Ludwig R. 3851180 Lim J. 635143 Liu G. 2991303 5201605 627 Look S. A. 3001362 Lue W. M. 4101417 Lim P. Y. R. 4101430 589152 Looman A. 5141101 Lueers J. 463182 Lim S. 2981174 Liu G. Q. 406177 Loomis W. D. 6031117 118 Luengo J. M. 312176 Lim T. K. 2981224 3011466 Liu G-L. 5201606 Loosli H.-R. 331177 Lugtenberg J. 218120 21 22 78 Lim Y.-H.1421104 5111365 Liu H. 20217 2911145 5891128 Lopes J. L. C. 1601189 2191111 116 117 118 121 Liman M. D. 383138 384142 Liu H. J. 159163 406181 Lopes N. 7114 Lugue F. J. 30319 Limat D. 6361108 Liu H-J. 5191520 521 522 523 Lopes 0.C. 1861678 Lugue L. E. 406161 Limbert M. 110l102 Liu H.-T. 2011 Lopez A. 1821242 Luibrand R. T. 2991253 Lin C. H. 5201647 5221764 Liu H.-W. 4511124 125 Lopez C. 1881838 Luis J. G. 981178 186 188 Lin C. M. 2571188 195 3001342 Liu J. 1431163 1601123 175 Lopez H. 121123 Luiten R. J. H. 2191118 1611246. 247 474118 5151173 Lopez J. A. 405136 Luk K. 331199 Lin C. Y. 3581230 67612 Lopez J. L. 71136 731151 255143 Lukacs G. 39/45 109/51 555189 Lin D. 406188 Liu J. H. 474131 32 5201598 Lopez J.-L. 131291 Lukanov L. K. 4011156 Lin F. T. 405136 Liu J.-J.463148 Lopez L. 5191527 Lukas S. E. 4101436 Lin F. Y. 4011189 Liu J. R. 2571169 312152 Lopez M. 981186 Lukashova E. A. 384145 Lin G. 2561146 Liu J.-R. 731132 Lopez M. 1601180 Luke G. P. 6511106 Lin H.-S. 3851189 Liu J.-S. 731210 211 Lopez M. L. 731291 Lumin S. 1811233 Lin J. 5151145 Liu K. 312193 Lopez M. R. 1821248 Lund C. 4081279 Lin J. T. 218185 Liu K. C. S. C. 731182 Lopez-Perez J. L. 131202 203 Lund E. 3851186 Lin L. 4011153 Liu K. J. 1881850 Lopez-Vazquez M. L. 71122 23 Lundquist K. 741242 Lin L.-C. 20145 Liu K. S. 1861677 Lopusinski A. 5 181406 Lunge U. 16U338 Lin L-J. 5211675 Liu L. 1611245 4091329 5141111 Lord M. D. 3001401 Luo C. 406170 Lin L. Z. 256199 123 125 126 5 19/51I Lorenc L. 384173 78 81 Luo G. 55316 Lin L.-Z. 72189 588141 6781138 Liu M.-Y.72/98 Lorenz M. 1421127 128 5211718 Luo H. S. 6111115 139 140 141 143 144 Liu P. S. 39160 Lorenz W. 4091356 Luo L. 4091336 Lin M. 5891112 Liu R.. 428155 56 Lorenzen K. 159141 Luo S. 5161263 266 Lin M. J. 4101417 Liu S. W. 5191554 5201594 Lorenzi R. 241169 Luo s.-Q.,72/89 Lin M. T. 4071138 Liu T. 4071129 130 Lorenzo P. 4091363 Luo Y. 5221795 6191205 Lin M.-T. 731182 218171 Liu W. 331153 3581207 4081226 Loreto F. 514157 60111 Lurcott S. M. 1861656 Lin P. 256199 5 181451 Lors M. D. 158131 Lusi A. 109148 49 Lin S. 15818 1611254 5191513 Liu W. G. 5171340 Lortie L. 406146 4081259 Lusk W. J. 24U140 Lin S. L. 4291129 Liu X. 406170 77 4071202 5191511 Losch S. 5181481 Luthra R. 142193 1431169 5161275 Lin T. 6791245 246 Liu X.-J. 141246 Loswick A.C. 40517 Luthria D. L. 1801146 1841476 Lin T.-P. 20129 Liu X.-P. 3841115 Lothstein L. 109128 1871753 Lin W. 38316 4091299 Liu Y. 406186 5221765 793 Lotina-Hennsen B. 1611213 Liitke-Brinkhaus F. 6031106 107 Lin W. C. 4071131 55611 60 Lotowski Z. 3861238 239 Lutskii V. I. 6781185 Lin W. H. 203132 2561102 Liu Y. L. 5221794 Lotter H. 72/95 2971124 Lutz A. 5211685 Lin X. 1871804 406187 Liu Y.-L. 2016 Lou D. 41 11450 Lutz G. P. 6361109 Lin Y. 406175 Liu Y.-Q. 671159 6181132 Lou F. C. 4081219 220 Lutz R.J. 60117 Lin Y. C. 474124 Liu Y. Y. 1841491 Lou H. X. 5111345 Liitzow M. 602134 6031114 Lin Y.-C. 618134 Liu Z. 1611276 5221779 780 Lou Z. 5211748 Luu H. V. 5141134 Lin Y-T. 5201642 6771109 6781196 LOU Z.-C. 421124 474110 79 LUU-DUC, C. 1841489 3841111 Lin Y.Y. 296172 Liu Z. Y. 1831356 357 LOU Z.-C. 6781160 6791201 Luu-The V. 3841100 Lin Z. W. 2561123 125 126 Livant P. 38318 Loughran M. S. 55315 Luxen A. 219198 Linan E. 255133 34 35 Live D. H. 296133 Loughrin J. H. 91/86 Luzina 0. A. 5211712 Lindberg G. 4091301 Livermore D. M. 3321126 Louis C. 651164 Luzzani M. 589191 Lindeman S. V. 1621298 Livinghouse T. 65916 Loukis A, 514181 Luzzio M. J. 590113 7 Linden A. 255124 303110 11 Livingstone R. 51313 Lounasmaa M. 588116 18 19 22 Lwe W. 5151177 196 5161243 41 11445 5201623 Livni E. 1841461 23 33 36 42 589195 100 I01 Lynch J. E. 3311105 Lindquist N. 30 1 1437 Lizarbe M. A. 3571184 Lourdusamy M. 3841114 131 Lynch K. O. 741254 Lindquist U. 296116 Lizasoain I. 4091363 Lovas S. 4081236 Lynch V. 721111 Ling D. 514l111 Ljungberg H.3581202 Love B. E. 428132 5201585 604 Lynch V. M. 39/43 Ling L. 4291127 Llabres G. 58812 5 Lovell J. M. 427119 Lynen F. 3571142 5561158 60U30. Ling T.-T. 109162 Llau M. E. 4081206 Lovely C. J. 3841121 31 59 Ling Y. 38316 Llobel F. 4091300 Lovering F. E. 303124 Lynn B. 463140 Lingens F. 4521176 Lloyd. H.A. 82/52 Lowden P. S. 450148 51 Lynn S. 5561172 173 Lingham R. B.. 15817 Lloyd M. D. 1431148 149 3321166 Lowinger T. B. 4291118 Lyske D. T. 4091310 Link J. T. 2561149 4281101 178 179 196 3331211 212 Lown J. W. 4291127 5901136 Lytollis W. 1831351 Linker U. 1831371 372 Lo H. M. 4071189 Loyola L. A. 255149 Linko R. R.. 1861659 660 Lo S. F. 4511124 Loyola-Vargas V. M. 371149 Linn B. O. 109148 49 Lo V. N. 5141125 126 Lozanova A. V. 159167 M Linn C.405114 Loayza I. 5141108 Lrum L. R. 5141109 Linner K. M. 4101419 Lobkosky E. 4631102 Lu C. C. 1611232 2991269 Linney I. D. 650138 Lobkovsky E. 2571230 2991262 Lu G. 5171313 Ma D. 4081252 Lins A. P. 5221807 Lobstein A. 6781180 197 Lu G. H. 406159 Ma K. 158126 2561108 2571209 Linsert Jr H.. 463/87 Lodwig S. N. 218146 47 48 Lu H. 406186 4071153 2971132 2991274 3001357 428161 Linstrumelle G. 1821301 2191101 122 Lu H. M. 406181 6181137 139 145 150 Linz J. E. 5561162 Loeffler S. 371126 Lu L. 109171 6781164 165 Ma L. B. 1611247 6771115 Lipponen S. 588116 Loes L. M. X. 4061110 Lu M. C. 20115 Ma S. J. 1591112 Lipscomb W. N. 241122 Lofsted C. 3581202 Lu Q. 463159 Ma W.-Y. 731204 Lipshutz B. H. 82/62 69 Lofstedt C. 96139 Lu S.-F. 3841101 Ma X. 255122 4081252 Lipska B.K. 4071200 Logie C. G. 659125 26 27 660160 Lu T. 256188 Ma Y. 5201605 606 Ma Y.-L. 731134 135 Liras P. 332lI49 192 5551115 61 Lu T. J. 5191554 5201594 Maat L. 4081228 Lis A. 5151221 Lognay G. 650155 Lu X. 1831339 Mabelis R. P. 555191 Lis-Balchin M. 5151147 Loh H. H. 4091344 Lu X. J. 6031105 Mabry T. J. 1621303 311 Lisgarten D. R. 383111 32 Loh K.-Y. 589173 Lu X. Q. 4101426 Macalintal C. 3311118 Lisgarten J. 383111 32 Loh T.-P. 650133 Lu Y. 5201595 McAlpine J. B. 450119 555171 72 Lisheng D. 2021.5 Lohray B. B. 5891124 I25 Lu Z. 4511111 76 97 Lithgow A. M. 159160 255150 51 Lohse O. 5181455 Lu Z.-H. 39129 40176 635118 19 McArthur C. 97166 Index of authors cited 1-71 McArthur H. A. I. 450149 50 55511I1 Macbeth J. 296160 Maccioni S.5161233 McCaffrey E. J. 3011443 McCall P. J. 97185 McCall R. 2571186 McCamey D. A, 4511174 McCapra F. 219194 241121 McCarthy K. 82162 McCarthy K. E. 82169 McCarthy M. J. 1861699 McCarthy S. G. 1881826 McCaskill D. 602152 66 McChesney J. D. 71111 203144 McClintock J. 3011479 481 McClintock J. B. 463162 McCloskey P. J. 618148 McCluer R. H. 1801106 McClure D. B. 3851189 McClure K. J. 71145 McComb J. A. 39123 McCombie S. W. 4291111 MacConnell J. 55611 76 McConnell 0. J. 2981209 McCormick A, 240110 McCormick J. L. 61714 McCormick K. D. 65011 7 McCormick S. P. 981201 1431155 156 157 158 188 189 MacCreadie J. M. 4081263 McCrimmon D. 3011493 McCrudden K. 1821282 McCubbin Q. J. 618165 McDaniel R.55314 554125 26 28 29 McDonald F. J. 3001398 399 McDonald I. A. 4511100 McDonald L. A, 3011465 4641113 McDonald M. G. 4521180 McDonald R. E. 1861688 689 1811718 Macdonald R. W. 67611 McDonald Y. M. 40515 Macek K. 1851610 McElhaney R. N. 450159 McElhaneyfeser G. E. 3511150 McEnroe F. J. 297198 3001334 McFarlane A. K. 5201637 McFarlane C. S. 71146 McFarlane I. J. 39125 2191104 MacFarlane J. K. 463167 McGarvey D. J. 14117 142198 24 1I49 McGeady P. 142196 109 McGiff J. C. 1801136 McGlinchey M. 3841104 McGrath M. 602178 McGregor D. N. 3311113 McGuire R. 38319 McGuire S. M. 5561164 Machado E. C. 82/40 49 Machado M. I. L. 5161239 256 Machev K. 40711 79 Machida K. 5221775 Machiex J. J. 981185 Machinek R.4511140 Machulla H. J. 1841490 Maciarello M. J. 5141105 109 5151155 I 76 180 223 Macias F. A, 971141 143 145 159170 514169 McIlwaine D. B. 3331208 218 372169 McInnes A. G. 2421175 176 553115 McIntyre G. 5901137 McIver L. A. 3581244 Mackenzie A. 6031139 Mackenzie L. 296169 McKenzie R. A. 39120 91156 65111I3 McKague A. B. 1841457 McKee T. C. 46218 475168 70 71 61714 McKeon T. A. 3571153 McKervey M. A, 6181171 McKetty P. T. 514179 McKie J. A, 4291124 126 McKinley T. C. 3571183 McKitty A. A. 3021495 3851169 McKnight T. J. 141133 Macku C. 5141115 McLachlan J. L. 296165 463138 555192 5561153 617171 72 73 74 McLaughlin J. P. 4101402 McLean M. G. 372194 McLean S. 96149 159173 2971148 3001333 361 381 650154 61614.8,677169 MacNeil D. J. 450121 5551106 107 108 109 MacNeil T. 450121 5551106 107 108 109 McMahon J. B. 475170 71 McMahon R. E. 109183 McManus M. T. 91183 McManus 0.B. 1591101 MacMillan D. W. C. 3001366 MacMillan J. 1431215 1441221 231 24012 5 7 10 11 13 241158 59 60 61 62 67 70 74 76 88 91 93 94 103 2421104 105 112 113 115 117 127 128 129 130 131 132 133 135 136 146 152 153 154 158 161 162 171 173 176 178 179 183 2431193 194 196 199 201 2561139 142 McMorris T. C. 10170 77 81 82 95 97 McNab H. 474139 McNeill G. P. 1881828 831 842 851 McNelis E. 5201601 McNulty J. 428139 McPhail A. T. 71129 741246 383124 McPherson M. 39155 McRee D. E. 356133 McRudden K. 356182 Madar Z. 981196 Madden J.L. 5151149 Madden M. C. 1861697 Madduri K. 553118 554145 Madec C. 450159 Madge D. J. 384169 Madgwick S. A, 20127 Madigan M. T. 35519 55319 Madinaveitia A. 202111 58819 11 6 17121 Madono T. 159146 47 2991251 252 Madrid L. H. 158123 2991261 Madsen P. 4101381 Madulid D. A. 255122 Madyastha K. M. 5161278 Maeda H. 1851523 Maeda K. 731198 1601161 1861642 45 11166 172 Maeda M. 1601193 462120 Maeda S. 72163 64 141251 4091335 Maeda T. 2971147 Maekh S. K. 6511100 Maerz L. 39135 Maes D. 383111 32 Maestri D. M. 5161228 238 240 Mafoti R. 218171 Magae J. 1601203 Magalhaes G. 677162 Magalhaes G. C. 5171315 Magano J. 1831383 Magee T. V. 1621330 Maggio J. E. 1101105 Magnier E. 428175 Magno S.296181 297196 2981201 234 2991307 319 Magnuson K. 355110 Magnuson S. R. 1601160 Magnusson G. 131139 Magotra D. K. 618161 Magrath J. 141149 Maguire N. M. 1881884 Mahajan B. 6791225 Mahajanshetty C. S. 1811154 Mahajnah Y. 2991293 Mahaman I. 159139 Mahara R. 3851156 Mahato S. B. 67711 I7 Mahiques M. M. 255147 Mahler R. 1831373 376 Mahling J. A, 415159 Mahmood C. 1821252 Mahmoud A-L. E. 5161277 Mahmound A. A. 513134 Mahmout Y.,255117 Mahon M. F. 40185 Mahran G. H. 5171366 Mai S. 2981207 Maia J. G. 475155 Maia J. G. S. 2019 1611229 61712 Maidment M. 38319 Maier I. 296184 Maier M. S. 3011478 384156 57 Maier W. 372160 61 Maiese W. M. 4641113 Maillard M. P. 1621357 Maille. N. 6511111 Maillo M.A, 159157 3001410 Maimirani M. 3861236 Maindreville M. 588132 Maiti D. K. 618166 Maiti G. 731156 157 180 Maiti M. 40711 74 Maiti S. N. 3311115 Maitland D. J. 1821239 240 Maitra S. K. 3581229 Maitra U. 3851162 164 165 Majak W. 401109 202114 659122 Majchrzak-KuczyfiSka U. 401136 635188 Majer Z. 588128 Majerus P. W. 356130 40 48 50 Majetich G. 384174 Majewski M. 1601152 6511107 108 Majidi L. 5181449 Majinda R. R. T. 6771105 Major D. A. 372194 Makabe K. 463153 Makalaska M. 4091343 Makarieva T. N. 2991323 324 301I448 Makela S. I. 71140 Makela T. 71/17 18 38 Makela T. H. 71141 Makhmudov M. K. 20147 48 1621324 Makhnach S. A, 5211673 Maki S. 475164 618172 Maki S. L. 2421137 Maki Y. 142170 71 72 15816 Makkinnon S.97194 Makleit S. 4081229 257 Maksimov 0.B. 141269 Malaivijitnond S. 4091362 Malan E. 741264 Malarz J. 1601200 Malatynska E. 4101423 Malcata F. X. 1871790 Malcolm J. M. 2411102 Malcomson M. E. 71145 Maldaner A. O. 39173 95 Maldonado E. 1601186 1611207 211 256194 6171121 Maldonado M. E. 1811166 177 195 198 Maldonado-Mendoza I. E. 141133 Mali R. S. 475156 111 Malich A. 1601150 Malik A. 611198 Malikov V. M. 1591100 1621294 Malkavaara P. 5191529 Mallarapu G. R. 6791223 Mallavadhani U. V. 1811209 Mallavarapu G. R. 5151159 185 Mallea M. 650120 Mallet A. I. 356185 Mallet J. F. 1871713 Malloch D. 6191239 Malmborg P. 218158 Malone J. F. 20125 32 Malone W. 1861661 Malosio M.L. 4091324 Malpartida F. 554146 Malpass J. R. 6511118 Malpert J. H. 5181463 Malterud K. E. 1851579 Maltsev I. I. 4641110 Malyer H. 5161248 Mamber S. W. 2571184 Mamdapur V. R. 1811204 1821280 285 1831334 Mamedova S. A. 5141120 Mamer O. 2571154 155 Mamiya Y. 383118 Manabe T. 65913 Manavathu S. A, 3321141 Mancera C. 1601186 Mancilla A. 255149 Mancini I. 2981220 2991271 421116 4641114 Mandava N. 911 Mandava N. B. 914 64 66 67 10171 Mander L. N. 1441230 24016 2421147 159 164 165 166 167 168 170 2431198 2561140 144 145 Manders L. 2421149 Mandville G. 39166 Mangani F. 474111 Manglano E. 5 111350 Mangold H. K. 1801100 Mangoni A. 2971138 139 140 2981228 246 2991293 319 Mani V. V. S. 1831366 M anickavasagar R .3 84/42 Manitto P. 602113 Mann J. 1831348 6031115 I20 Manna T. K. 6771123 Mannarelli S. J. 3571125 Manners G. D. 203123 Manning J. K. 109156 Mannkian A, 91186 Manns D. 5181484 5211683 Mano H. 1441249 Mansell H. L. 6511120 Mansfield J. W. 981181 182 Mansilla H. 1611206 Mansion M. 981157 Mansuy D. 109193 Mantellier P. 2571187 Mantis A. J. 1851519 Mantle P. G. 371139 Mantsch H. H. 450159 Manttari P. 5201659 Manukian A, 971123 Manzaneda E. A. 159159 3001411 Manzi A. 401128 Mao J. 4081262 Mao S.-S. 3321150 153 I71 Mar W. 6791205 Maranda L. 296159 60 Marat K. 38316 Marazzi G. 38511 74 Marc A. P. 4751106 Marc F. 5211695 Marcantoni E. 635110 Marcelo-Curto M. J. 256182 Marchand J.81113 14 82154 Marchand-Brynaert J. 3321127 Marchesini A. 427115 Marchesini G. 3841129 Marcireau C. 602190 Marco J. A, 72179 5161270 5171350 5191487 Marcos I. S. 159158 60 102 255116 50 51 Marcos M. 650142 Marcou L. 1881812 Mardarowicz M. 474119 Marder R. 25711 77 Marecak D. M. 1831410 411 412 413 414 Marek D. 635133 Marek I. 6361120 Marek R. 4071168 Mares P. 1801115 Margari L. 4081205 Margiatto G. M. 109149 52 Margulis L. 46213 Mariano P. S. 401144 Marigo G. 602153 Maring C. J. 2571174 Marinho L. C. 401103 Marion C. 514195 Mark G. 5141100 Mark G. P. 4091360 Markgraf J. H. 428166 1-72 Natural Product Reports 1997 Markkanen M. H. 71141 Maruyama K. 1871797 1881830 Matsunaga H.5201629 Meguro H. 1851595 Markowicz W. S. 159192 296168 463139 Matsunaga K. 731163 Mehdi S. 4511120 Marks T. J. 65915 Maruyama M. 1601193 Matsunaga S. 1841453 203136 37 Mehri H. 4011160 428187 Markus A, 1101102 107 Marx F. 1871755 38 2971137 2981183 184 199 Mehta G. 20135 1611215 5211667 Marlier M. 650155 Maryanoff B. E. 2981185 200 3011469 470 463127 6791248 618143 Marlin B. R. 5221812 Maryniak D. M. 5201589 Matsunaga T. 405112 Mehta P. K. 4511126 Marner F.-J. 296150 85 Mas M. 4071193 Matsuo A, 2431193 2991275 Mehta V. D. 20125 Marnett L. J. 1851536 556 3571181 Masamune T. 1611287 297192 3851158 Meier R.-M. 451197 Marotta E. 513118 Masaoka T. 12/56 Matsuo F. 2971103 Meijer A. H. 311141 602114 Marquais S. 5181457 Mascaretti 0. A. 81112 16 82/56 Matsuo K.158112 650151 52 Meinke P. T. 109145 Marquardt V. 913 Maslonek K. A. 4091310 Matsuo Y. 2971133 134 61615 6 Meinwald J. 6361133 134 65011 7 Marques M. F. S. 58816 Mason J. M. 39146 635135 Matsuoka H. 406172 18 Marquet A. 3581247 3851146 Mason R. P. 1851549 Matsuoka K. 1821256 Meissner C. 401121 Marr I. M. 514176 Massa J. S. 255166 Matsuoka T. 9136 Meister W. 1811772 Marr J. 1841448 296164 Massanet G. M. 1611257 Matsushima Y. 1611289 Meklati B-Y. 5141137 Marron B. E. 1841481 Massiot G. 3011457 4061109 Matsushita H. 131172 513116 Mekonnen B. 462114 Marsais F. 3011459 427127 28 29 42111 428197 58813 61711 67617 Matsushita K. 589167 Mekouar K. 589196 650156 57 Masters J. J. 2561149 33016 Matsushita M. 428158 Meksuriyen D. 731140 Marsch M. 6361114 Mastrocola A.R. 5901130 131 Matsushita S. 186161 7 Melchert H. U. 1861622 Marschall H. 158114 1591114 117 Masuda H. 12163 64 741251 Matsushita T. 296141 42 428163 Mele G. 5191527 I 6 11269 5 141103 5 161235 236 5221766 4631104 6 18/57 58 Mele S. 5211686 269 Masuda K. 159143 449111 6791222 Matsushita Y. 20155 618169 Melenski E. 650137 Marschoff C. M. 5171380 245 246 Matsuura H. 981165 Melhaoui A. 650120 21 Marsden A. F. A. 55315 555174 Masuda M. 2911133 134 67615 6 Matsuura M. 2971170 Meliboev S. 406162 Marsden S. P. 20152 Masuda T. 981180 2571202 Matsuura S. 72148 Mellerio G. 676117 Marsh E. N. 3321183 185 3001346 414130 Matsuya T. 4091335 4511149 Mellinger M. 5901130 131 Marsh K. 109191 Masui H. 1811231 Matsuyama Y. 5561163 Mello N. K. 4101415 436 Marshall J. A, 3001363 513110 Masukawa A.142172 Matsuzaki K. 312192 5561188 Melloni P. 3851174 6511106 Masuma R. 159142 Matsuzaki Y. 71/19,40512 Mellor J. M. 3861229 Marshall M. S. 60115 Masushige S. 1441249 Mattana J. 4091319 Mellor L. C. 218169 Marshall S. 4081275 Mata J. M. 330133 45 Matthews M. 330121 Melville C. 555151 Marsili A. 131126. 4081218 5211686 Mata R. 1611213 251 Matthijs G. 109192 Melville C. R. 372187 88 4511150 Marsura. A. 384111I Matagne A. 330128 Mattia C. A. 159151 2991257 258 158 159 160 555156 Martens S. N. 96142 43 44 Mataix A. L. 4071199 309 311 Melzak R. 4081267 Martichonok V. 3581191 Matamoros R. 5 181425 Mattiacci L. 97184 Menachery M. D. 4011183 Martin A, 218141 42 43 3851191 Mateos A. F. 5211699 Mattiasson B. 1881863 Mencia-Huerta J. M. 71125 26 Martin C.5561196 Matern U. 6031137 138 Mattson W. J. 96146 Mendelson J. H. 4101436 Martin C. E. 3571178 Matha B. 2981198 Matusch R. 731200 30312 17 19 Mendez P. 635167 Martin G. E. 296170 3021496 Mathee S. 30318 Matzuk A. 109148 49 Mendez C. 555149 50 84 85 589156 104 Mathela C. S. 5141102 5151146 192 Mau C. J. D. 1431196 Mendoza L. 255112 Martin J. F. 3321149 175 192 Mathenge S. 659124 Maulshagen A. 1101107 Mendoza Y. A. 1811228 Martin J. F. 5551114. 115 Mathenge S. G. 20116 406138 Maurelli S. 3011479 Mendy F. 1811744 Martin M. 97168 1851605 611115 Maurer W. 5211735 Menelaou M. A, 971143 144 Martin M. I. 4101410 Mather L. E. 4101368 Maurya R. 255157. 58 159170 Martin M. T. 427126 589157 Mathias K. 158138 Maurya S. K. 82123 28 671161 Menezes A. S. 82/43 6181126 Mathivanan P.3851164 Mavar-Manga H. 58815 Menezes M. A. C. 514171 Martin P. 5211694 Mathur H. H. 2971135 Mavi S. 5211747 Menezes R. F. 109177 Martin P. R. 3321191 Mathur J. 10198 Mavlyankulova Z. I. 255128 Meng F. 406174 Martin R. J. 109147 Mathur M. 356184 Max F. 1811191 Meng Q. 4111461 Martin R. L. 405127 Mathur R. K. 5141139 Max W. 96119 Meng X.-Z. 401112 116 117 Martin S. 731202 Matikainen J. 1811173 1831359 Maxwell A, 203142 Meng Z. 6711116 Martin S. F. 39142 43 428177 3011424 425 Maxwell J. R. 463180 Menge U. 1881839 589162 63 Matlock M. G. 1861686 Maxwell R. J. 1851584 Mengliev A. S. 255140 Martin T. S. 255160 Mato C. 12/86 Maxwell S. 660171 Menhard B.,602158 Martin U. 4101398 Matos F. J. A, 5161239 256 Mayer D. J. 4081262 Menna M. 2981235 Martinelli E.450185 451189 Matos H. A. 5111374 Mayer F. 356170 Mentermans W. D. F. 405119 52 1I664 Matsko T. H. 589165 Mayer G.,4291114 Menut C. 5 14186 5 151150 152 205 Martinez A. 255133. 34 35 Matson J. A. 1101109 428193 Mayer J. 5191570 212 5161234 261 2561130 2991301 302 Matsubara M. 602l83 Mayer K. K. 40191 Menziani-Andreoli E. 414112 Martinez A, 1611260 Matsubara T. 1801119 Mayer M. 555194 5561136 177 I78 Merand Y. 3841131 Martinez A. G. 5201580 Matsuda C. 428154 4631107 Mayer R. 1621343 405115 Mercadante L. 5 161300 302 Martinez E. 554146 Matsuda H. 428153 617151 Mayes D. M. 1861692 Merchan F. L. 6361125 Martinez J. R. 5141115 6781148 153 178 179 Mayoral J. A. 5181416 427 Mercier M. F. 474126 Martinez L. E. 5171376 Matsuda N. 475177 5221775 Mayrargue J.20124 Mercola M. 203152 Martinez R. 1611206 Matsuda S. P. T. 616111 Mayumi K. 10172 Merello S. 39134 Martinez T. 3571187 Matsuda Y. 4511172 Maze F. 1811746 Martinez de la Ossa E. 1861667 Matsudaira T. 4291128 Mazerski J. 1101101 Mericli A. H. 12182,83 Martinez-Gonzalez J. 141119 20 27 Matsuhira M. 6791238 Mazliak P. 1871785 Meriqli A. H. 20219 13 Martini M. C. 11/37 39 Matsui J. 520f616 617 5891111 Mazur A. W. 1881847 Mericli F. 12182 83 Meriqli F. 20219 13 Martini N. 35111 70 Matsui K. 1811150 222 Mazur J. 415180 Martinko J. M. 35519 55319 Matsui M. 5201634 Mazur P. 1821310 Merienne C. 428175 Martinkus K. J. 3331213 Matsukawa Y. 296175 Mauarella L. 2991311 Merifeld E. 651179 80 Martin-Lopez M. J. 39112 Matsuki Y. 384198 Mazzei R. A. 5221787 Merifield E.5201650 Martins J. C.. 383111 Matsumori N. 296162 463137 Mazzei T. 109180 Merino E. F. 401114 5161228 Martins M. A, 71/43 Matsumoto F. 5151156 Mazzola E. P. 296170 Merino M. 731202 203 Marton J. 4081229 Matsumoto G. 463195 Mbairaroua O. 513121 Merino P. 6361125 651189 Martonfi P. 513139 Matsumoto G. K. 2971167 Mbark A. N. 6181158 Merkuza V. M. 82156 Martyn J. A. J. 406195 97 Matsumoto H. 131132 2981184 M’Boungou-M’Passi A. 5201615 Merlini L. 5561186 Marubayashi N. 5221777 677170 Matsumoto K. 1861646 2991316 Mead E. W. 5211715 Merrer Y. Le 1821318 Marui S. 109190 331155 513116 Meada T. 97/99 Merriman G. D. 3861229 Marumo S. 9/26 27 48 4081217 Matsumoto R. 5561179 180 Medarde M. 71136 1601174 255143 Merritt K. D. 2191114 3331209 Marumoto R. 6791244 Matsumoto S.3011472 473 Medina E. 81117 Merritt L. A. 96131 Maruno M. 71/19 721104 105 106 Matsumoto T. 741253 256198 101 Medina I. 1871728 730 733 747 Merson-Davis L. A, 555181 107 108 109 12/70 741214 223 127 372151 5221789 Medina R. 21719 Mesentsev A. S. 450184 224 1611253 256189 40512 Matsumura E. 72148 296141 Medina-Bolivar F. 311116 Messana I. 141274 5 13/35 52 11741 6791212 240 463194 618157 Medoff G. 109196 Messeguer A. 1841458 676113 Marusawa H. 450140 5551100 Matsumura H. 256198 Meerow A. W. 30313. 14 Messenger A. J. 4511165 Maruta Y. 981183 1611224 Matsumura S. 356177 Mega T. 635124 Mestres T. 1611221 Maruyama J. 731173 Matsumura Y. 721118 218165 Megges R. 3851172 Metcalf R. L. 971130 Index of authors cited 1-73 Metz B. 3861215 Metz P.1611262 Metzger J. D. 241164 2421141 Metzger J. O. 1821278 1831369 370 371 372 373 374 375 376 377 378 379 380 381 382 Metzger P. 1811206 5201596 Meudt W. J. 9169 Meulman P. A. 450177 Meunier B. 20127 Meusel D. 1881852 Mewett K. N. 4291130 Meyer A. 6781146 Meyer D. 981158 Meyer E. 33211 74 Meyer K. D. 1611231 Meyer M. 4511140 Meyer M. W. 97165 Meyer T. 4281102 Meyer W. E. 450183 Meyers A. I. 39169 Meyers A. I. 159195 4061106. 107 651197 Mhaskar S. V. 218171 Mhaskar S. Y. 1821302 307 324 1831366 Mhin B. J. 5201641 Mi A. 5191552 Mi A. Q. 5201611 612 Mi J. F. 5211727 Mi Y. 41 11461 Miana G. A. 82125 29 60 Miao K. L. 1611253 6771112 6791212 Miao S. 2981239 Miao Z. C. 6781160 Micetich R.C. 731197 Micetich R. G. 3311115 Michael J. P. 618128 63518 Michaels P. J. 3571183 Michalski J. 5181406 5201584 Michne W. F. 3841109 Mickel A. 21 8/77 Micouin L. 1811216 Midland M. M. 3861216 Midland S. L. 97199 981200 297199 Mieczkowski J. B. 405118 Miersch O. 1811217 1851555 Mierzwa R. 159148 2991249 Miesink R. J. M. 4091297 Miettinen J. 588133 Miguel M. D. 5151178 Miguel 0. G. 5151178 Mihailovic M. Lj. 384173 78 81 Mihaliak C. 513145 Mihaliak C.A. 141112 Mihan S. 5891108 Mihara T. 255125 Mihashi K. 677170 Miikki L. 589195 Mikami S. 296125 Mikami Y. 2971149 Mikamiyama H. 2561132 Mikhailov V. V. 4641110 Mikhailova M. V. 1811169 296179 Mikhal‘skaya T. Yu. 4071126 Mikhova B. 47412 5221758 6781195 Miki I.602141 Miki M. 1851530 Miki W. 296135 462121 463129 Miki Y. 589167 Mikkelsen J. D. 981170 Mikkola T. 4091354 Mikus G. 4101399 Milanova R. 256190 Milanovic M. 1621313 Milat M.-L. 5561190 Milenkov B. K. 5141135 Miles C. O. 428179 81 Miles D. H. 971100 Miles E. W. 4511128 Mil’grom E. 405131 Mil’grom E. G. 296131 4751118 618/32 Mil’grom Y. M. 296131 Miljkovic D. A. 384190 Miljovic D. 383128 Mill S. 651165 83 Millan J. G. 97199 Millar A. P. 5191525 Millar J. G. 158110 Miller A. K. 330143 Miller C. 1881807 Miller D. D. 218155 Miller J. G. 96136 Miller J. R. 372178 Miller K. L. 5151218 Miller M. W. 39144 3011491 Miller R. 1601140 Miller R. A. 3861227 Miller S. A. 635130 Miller S.L. 159173 2971148 3001333 361 381 67618 677169 Miller S. P. F. 3331207 Miller T. 330146 Miller T. A, 82169 Miller T. W. 330134 43 Millet J. 1831363 Mills K. A. 1851534 Mills N. S. 5171376 Milne K. 2191104 Milner D. J. 5181404 Milner N. P. 10188 Milone A. 2991265 3001364 Milone C. 5161302 Mimura N. 5171325 Min L. 5181470 Min S. J. 5191546 547 Min Z. D. 474144 45 46 Minale L. 1811213 296118 2981179 2991266 315 3011476 477 479 480 481 450163 4641115 Minami M. 4101371 Minami T. 40711 72 Minematsu T. 5171347 6791248 Minetti M. 4091318 Ming C. H. 255162 Ming L. C. 5151178 Ming L. M. 1611249 Minghetti A. 428184 Mini E. 109180 Minich M. 1841491 Minimatsu M. 4071198 Minks A. K. 971122 Minksztym K.2991321 3851208 Minnaard A. J. 1601177 Minnikin D. E. 1821282 283 284 356182 85 97 98 Mino M. 1851530 Minoura K. 296140 42 428154 428163 463194 107 618158 676135 Mintz M. 5221811 Mioskowski C. 1821292 1831362 363 1891902 Mirajkar A. M. 1821252 253 Miralles J. 18 111 76 179 196 216 Miramonti J. 372181 Miranda-Ham M. L. 371149 Miric A. 41 11454 Miro M. 677150 Misawa M. 4091293 4101420 Misawa N. 142180 Mishra M. 1621319 Mishra P. 180174 Misra I. 141116 17 5161258 Misra S. 1811184 Misra T. N. 6791221 Missling C. 5891108 Mistry K. M. 1831360 Mitaku S. 617111 618174 Mitamura K. 3861222 Mitani M. 981193 Mitchell P. J. 650132 Mitchell S. J. 3001355 Mithani S. 555157 Mitome H. 2991320 3851207 Mitrasov Y.N. 5191517 Mitrovic A. D. 4291130 Mitscher L. A. 2571186 Mitsuhashi H. 721104 105 106 107 108 109 741218 219 223 224 5211741 Mitsunaga K. 428165 Mitt T. 1831368 Mittag M. 3571147 55317 Mitzutani J. 721124 Miura J. 618139 Miura M. 6361124 Miura S. 1441244 Miura Y. 741247 617117 Miyabe Y. 588115 Miyachi S. 463183 4641109 Miyagishima T. 721101 Miyahara K. 6781132 Miyakawa J. 981190 Miyake T. 7311 78 372192 651193 6791242 Miyakoshi M. 6771102 Miyakoshi T. 5 13120 5201593 Miyamoto K. 5181428 Miyamoto K.-I. 72150 Miyamoto T. 2571218 296141 30013 76 394 30 1I4 73 46311 04 6 18/57 Miyano S. 731189 Miyaoka H. 2971165 2991320 3 581242 38 5/20 7 Miyase T. 731172 6781131 163 166 173 I74 Miyashiro H.74/21 7 463183 4641109 Miyashita K. 1851543 544 545 546 1871805 Miyashita M. 731159 165 169 173 384149 428158 5211733 Miyashita T. 406140 Miyata J. 159193 94 Miyata M. 3851158 Miyata S. 450138 Miyauchi N. 475182 Miyazaki K. 109172 Miyazaki Y. 1601179 Miyazawa M. 15819 159174 106 1621340 255136 Miyazawa M. 5151184 5171364 Miynihan H. A, 4101416 Miyoshi-Saitoh M. 5561128 Mizen L. 331164 Miziorko H. M. 141116 17 Mizoshiri H. 5221777 Mizuguchi T. 4101387 Mizukami F. 1841505 506 Mizuki K. 677170 Mizung H. 741217 Mizuno A. 474141 Mizuno K. 3581239 4511145 Mizuno S. 356190 475150 Mizusaki T. 741276 Mizuta E. 450182 Mizutani J. 971101 981183 1431144 145 1611224 265 255146 2561115 Mobashery S.3321141 Moc T. V. 39168 Mocaer E. 4071197 Mocanu A. 217116 Mocek U. 1441253 3561102 371133 450125 26 45111 73 Mochales S. 330133 43 Mock D. L. 45211 76 Modi S. R. 4751103 Mody N. H. 3571143 Moelgaard P. 5221799 Moeller M. H. 5211672 Moeller S. 384183 Moellering Jr. R. C. 330132 Moerland J. 4081235 4101395 400 Moffett M. W. 39163 Moghaddam M. 3571132 Moghaddam M. F. 1891897 Mogil J. S. 4081276 Mohakhud P. K. 741256 Mohamadi F. 5 191487 Mohamed A. H. 3571143 Mohamed K. M. 2571206 6781147 Mohamed M. H. 401106 107 Mohammad F. V. 6781182 6791204 Mohammed B. S. 1801146 Mohammed M. E. M. 4091338 Mohan K. C. 3001343 Mohan R. 428138 Moharram S. M. 6511105 Moine G. 1811158 Moiseenkov S.M. 159167 Mok P. H. L. 514179 Molad Y. 41 11452 Molander G. 3001400 Molander G. A. 1601164 171 Molangui T. 5151150 Molchanov L. V. 20147 48 618162 63 Moldow R. L. 4091313 Moldvai I. 589192 650135 46 Mole S. 97163 Molero A. 1861667 Molina P. 3011458 Molina P. E. 4101394 Molinaro A, 741230 Molinatti P. 20112 Molinero A. A. 1441255 Molinski T. F. 1811214 1841444 2971143 155 29811 72 247 3001388 3011449 Molitor T. W. 4091311 322 357 Mollema C. 971122 Maller B. L. 372164 65 66 Mollerup J. 1861652 Molli J. S. 5211680 Mollo E. 3001408 Molloy K. C. 40185 Molnar I. 450120 45 46 Molyneux R. J. 39116 20 24 38 39 97156 635125 6511113 659132 660174 78 Momose K. 6031109 Momose T. 635149 51 6361131 651177 86 Momose Y.4071147 Monaco P. 741230 158118 1821244 6771110 Monaghan R. L. 330145 450144 5551102 5561176 Monde K. 372153 54 Monden T. 1611287 Moneti G. 71115 Money T. 5201588 Moneyron H. 5201586 Monitto C. L. 4091340 Monseur X. 82154 Monsigny M. 109131 Montagnac A. 405125 Montamat F. 141125 Montastruc J. L. 4081206 Montastruc P. 4081206 Montaudon E. 5191528 Monteiro A. M. 1441234 2421151 Montenegro D. A. 296128 Monteserin M. C. 3851150 Montet D. 1881806 811 812 861 Monti H. 5211702 Monti J. P. 5211702 Montiel-Smith S. 384150 Montrozier H. L. 356189 Monypenny D. 4511101 Monzo-Oltra H. 1601152 Moody C. M. 218160 61 62 64 Moody J. O. 4061115 Moon B. H. 463162 Moon C.-K.731128 Moon J-H. 5161263 264 Moon K. 141130 Moon S.-S. 618124 36 Moore B. S. 3561102 3571103 104 450125 26 28 29 49 61 69 70 Moore C. J. 5181452 Moore D. D. 203152 Moore K. S. 3011493 Moore M. 256190 Moore M. H. 108111 109121 Moore R. E. 296150 55 56 371118 553111 90 Moore S. A. 1801128 Moore T. C. 241124 25 27 Mootoo D. R. 203142 Moo-Young M. 5 161283 Moquin-Pattey C.,3011460 Mora G. A, 405135 Moran G. 1601144 Morales A. 5171326 Morales G. 255149 Morales M. 4101378 404 Morales N. R. 1601145 Morales R. 1811153 Morales-Rios M. S. 428171 Morales-Ros M. S. 20146 Moralles J. 1811197 1-74 Natural Product Reports 1997 Moratti S. C.,255144 Mortreux A. 5161299 Mummery R. 96/15 Miiiirisepp A.-M.3571129 Mordini A. 5 191534 Morzycki J. W. 3861224 238 239 Munakata K. 9126 Muyard F. 2015 474126 Mordue A. J. 97192 Moseley W. M. 3918 Munakata Y. 1891904 Muzart J. 5201615 Moreau P. 1801147 35711 71 Moskova M. 3851155 Munavu R. M. 659124 Muzquiz H. 635167 Morehouse K. M. 1851526 Moskowitz H. 20124 Munchhof M. J. 39169 Muzquiz M. 401123 125 131 Moreira E. A. 5151178 Mod A. 513129 31 5181454 Miinck E. 35711 72 Mve-Mba C. E. 5151205 5161234 Morel A. F. 81115 82137 39 40 Moslein E. M. 602130 Munday-Finch S. C. 428179 81 Mville G. 5201645 43 44 48 49 50 51 Moss C. J. 981147 Municio A. M. 3571184 Mwange J. W. 5151196 5 161243 Morelli I. 731126 4081218 475186 Moss J. 4091356 451194 Munos M.-H. 20124 618131 Myasoedov N. F. 218123 5 161233,521 1686 5221774 Mosser H.C. 4081263 Munoz O. 650115 Myers A. G. 2421169 Moreno P. R. H. 371140 43 Mosset P. 1821327 1831388 Muiioz O. 1611230 Myers D. 180156 Moreno-Murillo B. 406161 Mosslemin-Kupaii M. H. 255123 Munoz-Collazos S. 5151189 Myher B. 203151 Moreno-Valenzuela O. 37 1/49 Mossman B. C. 5181439 Munro D. 401109 Myher J. J. 1801114 1861668 Moresca D. 5181418 Mossoba M. M. 1861688 689 Munro M. H. G. 372194 Myllyla R. 3321187 Moreton R. S. 180170 Mostardeiro M. A. 82143 Munsoor M. 1611256 Mynderse J. S. 296150 55 56 Moretti C. 61711 Motamedi H. 450152 554139 43 Muolo D. 4101380 Myrnes B. 1881843 Moretti R. 218135 36 40 5551101 Murahashi S. 618142 Morgan D. O. 1841470 1851552 Motel A, 3571138 602121 Murai A. 1611287 288 296167 68 570 571 1881886 Motherwell W. B. 5201657 2971116 I17 127 463139 Morgan E.D. 96125 26 Motles E. 4101388 Murai K. 6511103 N Morgan K. M. 589151 Motoo S. 5201652 Murakami K. 2561131 132 513137 ~ Morgan N. 218169 Mototani Y. 1431166 5 151184 589190 676148 677149 Morgant G. 589182 Mottadelli S. 41 11447 Murakami M. 428153 463153 Nabeta K. 1431158 166 167 168 Morgenlie S. 4081235 Motyka L. 589165 5 18/41 4 177 191 203 204 205 1601124 Morgenstern M. R. 450135 Moubasher M. H. 4071150 Murakami N. 1811226 3851177 125 1621346 Morgenstern T. 1611252 Moudachiroo M. 5151141 5171347 5191488 677151 6781148 Nable R. 6031130 Mori A, 5171329 Moulis C. 20114 153 178 179 Nacci A. 5191527 Mori K. 9140. 159175 1611268 289 Moulis G. 677190 Murakami T. 6781148 153 178 Nadinic E. L. 475189 95 2971107 147 51317 5171331 Mouloungui Z.180198 179 Nadizadeh H. 5201598 5211704 554122 Moulton Sr. K. J. 1841494 Murakoshi I. 40198 99 106 Ill Nadkarni K. K. 159183 47415 Mori S. 42714 Mour A. H. 4751112 113 141 635183 Niiesch J. 451193 95 98 Mori T. 4101420 Mousdale D. M. 3331197 Murakoshi Y . 406169 Naeed A. 5221785 Moriarty R. 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J. 65918 52 53 2971111 3571133 3581203 Morris D. G. 5191566 Muller C. 96153 296151 Murray R.D. H. 47411 462113 Morris J. 3331198 Muller D. 1101102 105 107 Murtagh A. J. 4101441 Nagnan P. 3581202 Morris J. L. G. 4081210 Muller D. G. 296185 Murtaugh M. P. 4091311 Nagoya I. 6711119 Morris L. J. 3321195 Miiller G. 3571147 151 55317 Murthi K. N. 5201598 Nagoya T. 1431168 1601124 Morris R. E. 450142 5561157 Murthy M. V. R. K. 3001372 3001404 Morris S. A. 256177 3571108 Miiller J. C. 331181 Murzin D. Y. 5171396 Nagpal P. 10196 97 Morris T. W. 356124 Muller J. G. 3851167 Musial S. T. 109169 Naguib M. 406154 Morrison A. 24111 7 Muller L. 4511147 I48 Musser S. M. 3021496 Nagy F. 10198 Nagy G. 1611250 Morrison H. 384176 77 5201595 Muller M. 4511134 Mustafa J. 1831404 428 1841430 Naheed S. 1811200 Morrison P. J. 3311109 Miiller R.,4511135 433 434 435 443 Nahrstedt A.4071175 Morrison W. R. 1851599 Muller S. 981150 151 Mustafin A. G.,4091345 Naidu B. N. 401145 Morrissey M. M. 428138 Miiller W. E. 401129 Musza L. M. 677179 Naik H. B. 4751103 Morse D. 463135 Muller W. E. G.,2981229 Muth A, 6361123 Naik J. T. 371139 Mortimore M. P. 589162 63 Mullin C. A. 96152 Muto N. 555182 Nair M. G. 71110 1811208 Morton J. F. 82152 Multari G. 6781194 Mutschler M. A. 971120 Nair M. S. R. 1431170 Morton M. S. 71116 Mulzer J. 427130 Mutsuzaki T. 1811229 Nair V. 3851163 Index of authors cited 1-75 Naito T. 651171 Naitoh K. 3011431 651173 Najera C.,5171324 Naka Y. 731207 Nakachiyama M. 72150 Nakagawa A. 372192 450116 45 111 49 156 555189 Nakagawa K. 2981226 Nakagawa M. 428134 35 Nakagawa S.,9151 Nakagawa T.4101371 Nakagawa Y. 331155 Nakahara A. 5211716 Nakahara S. 2981219 Nakahara T. 1851548 1881873 Nakai A. 3311115 Nakai H. 296140 Nakai M. 4631107 Nakajima A. 3001349 Nakajima H. 5561163 179 180 181 Nakajima N. 411156 219197 Nakajima R. 5161264 266 Nakajima S. 161/2IO Nakajima Y. 731161 Nakamata H. 159194 1861615 Nakamoto T. 651169 Nakamura F. 4101427 Nakamura H. 296167 68 2991294 4511172 463135 36 39 79 651170 Nakamura I. 1601126 255155 2971103 Nakamura K. 9111 Nakamura M. 1881830 3001406 407 4081237 677193 Nakamura S. 9120 255136 2571202 3001346 4511166 Nakamura T. 109138 1601149 1851522 523 203140 256183 Nakamura Y. 218175 677176 Nakan M. 3851207 Nakane K. 3001407 Nakanishi H.1841485 Nakanishi K. 9/10 1821310 296172 4521190 5561148 Nakanishi T. 676141 6791237 Nakanishi Y. 981183 1611224 Nakano H. 1871797 255156 3851192 Nakano K. 676148 677149 Nakano M. 2991320 Nakano T. 159157 3001410 Nakao H. 384160 Nakao Y. 2981183 190 248 428192 Nakashima K. 159199 1621345 6771122 Nakata D. A. 1431214 241181 Nakata M. 2971103 Nakatani I. 3861222 Nakatani K. 5211740 Nakatani M. 97193 1611266 1821256 2571202 3001346 5211716 677176 85 86 88 Nakaya N. 1851580 Nakayama H. 5181405 554137 Nakayama M. 9112 13 14 17 31. 36 731132 1851529 2421149 162 166 297189 2991275 5 171344 Nakayama N. 144121 7 677176 Nakayama S. 1871797 1881830 Nakayama T. 1811151 152 1871761 762,769 3861228 Nakazato Y.1601192 Nallin-Omstead M. 55611 75 Namba S. 384/98 Namba T. 741216 21 7 203143 4071147 474123 676137 Nambara T. 384198 Nambiar K. P. 3581249 Nambu M. 296145 46 Namera A. 58818 Namiki K. 1831341 Namiki M. 72153 Nan F. 1611245 5181470 Nanayakkara N. P. D. 71111 Nandanan E. 5891124 125 Nanduri S. 677175 Nangia A, 5181458 5211729 Nankai H. 15819 159174 106 Nantermet P. G. 2561148 2571183 463148 Nanya S. 1441217 Naoki H. 2971115 3011429 383118 677188 Naoshima Y. 1891904 Naota T. 618142 Napoli J. L. 1441239 240 248 Napolitano E. 384188 92 93 94 Napolitano G. E. 1801113 186/676 Narantuya S. 4751118 Narasimhan C. 141116 Narayan M. S. 5201579 Narayanan C. S. 5171368 392 5 191526 Narita N.5171311 Narita Y. 555164 Narjes F. 5171332 Narukawa Y. 218173 Naruse M. 20136 39130 618144 45 Narushima M. 9119 Nascimento J. 1621343 Nash R. J. 39124 58 59 96112 635122 36 65 1 1112 Nasini G. 1601167 5561186 Nasir H. 1591107 Nasir M. A. 651182 Nassar M. I. 159153 474/25 Nasu S. S. 159149 2991260 Nath S. C. 5141129 139 Natkaniec I. 5191570 571 Natori S. 4751119 Natori Y. 44917 Natsume M. 9119 20 4291122 650136 Nauteil G. 65015 Navarro A. 1611207 Navarro E. 731160 Navarro M. C. 5161252 Navasimhan N. S.,97195 Naya N. 463150 Naya Y. 383118 Nayler J. H. C. 330113 14 Nazabadioko S. 3011457 428197 Nazhimitdinova N. N. 1591100 Ncube I. 1881863 N’Diaye I. 427116 Ndiaye S. A. 5181465 Ne L.4091329 Neal R. J. 3321168 372171 Neal T. 602172 Neal T. R. 142168 Necco A. 109124 Nedea M. E. 2571154 I55 Needham J. 463124 38 555192 5561151 153 Neef G. 3851144 Neethling D. C. 602178 Nefedov 0.M. 4081227 Neff W. E. 1851544 545 546 Negi A. S. 3841123 Negishi R. 20123 Negri J. T. 158131 3001401 Negro A. 3321175 Negron V. 1821247 250 Negueruela A. V. 97197 Negus S. S. 4091348 4101415 Neh H. 384172 517/322 5181462 Neil E. 41 11453 Nellans H. N. 109191 Nelson A. J. 141131 Nelson L. A. K. 159163 Nelson M. 1611286 Nemecek J. 428185 Nemere I. 3861216 Nemeth K. 10198 Nemori R. 241173 Nemoto H. 159193 94 5181430 Nemoto T. 3001406 407 Nencini P. 405110 Neri G. 5161300 302 Neri P.2571203 291197 Nerle J. C. 406151 Nessler C. L. 141133 5561197 Nestby P. 4091325 328 332 355 359 Nester J. E. 2421167 Nethaji M. 475148 Neto J. O. 677181 Neto M. A. 5151215 216 Netting A. G. 1851591 Neuenschwander M. 1611279 280 Neugebauer W. 158119 Neuhaus M. 1601154 Neuman R. S. 4091329 Neumann H. C.,3841109 Neumeyer J. L. 6511110 Neurath H. 330126 Nevado M. V. 3851150 Neville C. F. 20131 32 618133 Nevitt G. A. 96141 Newall C. E. 331192 93 3321180 Newborg M. F. 109186 Newkome G. R. 450131 Newman K. A, 463167 Newmann J. R. 4081263 Newton G. G. F. 330116 Newton M. G. 618159 Newton R. D. 981203 Nezan E. 463176 Ng J. C. 1601168 Ng K. H. 72151 Ng S. 1871711 Ng S. C. 5191569 Ngadjui B. T.256178 Nganga J. 406138 Nganga J. N. 20116 617115 Ngnokam D. 67617 Ngooi T. K. 1881840 Ngouele S. 72169 Ngounou N. F. 6781126 Nguyen B. T. 5141127 Nguyen L. T. 3331203 Nguyen Q. C. 5151186 Nguyen T. T. H. 3851171 Nguyen X. D. 5141127 Nguyen-Huy D. 589182 Ni L. 4511111 Niac G. 217116 Nicaise 0.J.-C.,411156 Nicholls I. A. 589/111 Nichols M. L. 4081274 Nicholson L. W. 5191550 Nicholson N. H. 331170 71 3321159 162 163 169 170 173 178 179 196 33311 97 198 200 215 Nick A, 6771106 Nickisch K. 384172 5171322 5 181462 Nicolaou K. C. 109153 60 61 65 68 1801124 126 1821312 1841481 2561148 150 2571183 296173 74 2981185 5561126 Nicolas G.,6781180 Nicolau K. C.,463145 48 Nicolaus B. 1811207 Nicolaus-Dechamp N.5181397 Nicoletti D. 3851141 Nicoletti M. 1611230 5211717 5221752 774 787 589153 Nicoletti R. 463169 Nie R. 203139 5221795 Nie R.-L. 677156 57 Nie X. 2561146 Nieger M. 2581238 405115 Nielsen B. 3311108 Nielsen B. J. 1421115 5211745 5221788 790 Nielsen J. B.. 450144 5551102 Nielsen J. E. 981170 Nielsen J. K. 971125 Nielsen K. K. 9811 70 Nielsen P. E. 71124 Nielsen P. H. 3001391 428169 Nielson S. E. 6781199 Nieri E. 4081218 Nies A. S. 1871773 Niessen W. M. A. 60119 Nieto D. A. 1601162 659123 Nieuwenhuis S. A. M. 5181471 Nihira T. 3581239 240 241 Nijhof G. J. 4101408 Nikaido T. 6781169 Niki E. 1851547 Nikiforov A, 514185 5151164 214 Nikishin G. I. 3851154 Nikitina G. V. 3851153 Nikolic N.A. 6361103 Nikolov B. 4091343 Nikolova-Damyanova B. 1861631 Nilanonta C. 5181485 Nilso M. R. 4081243 Nilsson B. 1861648 Nilsson J. L. G. 256184 Nilsson L. A. 971135 137 513136 Nilsson U. 256184 Nilsson W. B. 1861649 Nimgirawath K. 255121 Nimtz M. 6781130 146 Ning S. 4511116 132 133 Ninomiya I. 651171 Nirmala K. 4751110 Nishada R. 660147 Nishi A. 20140 1591104 5561191 192 194 195 Nishi K. 1821269 Nishi M. 6791237 Nishi T. 4291126 Nishi Y. 1441217 Nishibe S. 72152 475182 5221754 Nishida A. 5181424 Nishida I. 356144 Nishida K. 428170 Nishida M. 5181424 Nishida R. 96114 15 16 971109 Nishida S.,4101370 5171330 Nishigaya K. 741247 61 711 7 Nishijima K. 406172 Nishijima M. 4631105 Nishijima T.1441230 2421147 2561140 Nishijo Z. 4071119 Nishikawa K. 406172 Nishikawa N. 101104 105 5211746 Nishimura H. 1611253 Nishimura K. 4081224 232 Nishimura M. 35711 76 Nishimura T. 1601203 4291107 Nishino H. 5221809 Nishino T. 142159 85 602141 42 84 85 95 Nishio M. 5171373 Nishio T. 1881841 651177 Nishitani K. 1611261 4081282 Nishitani T. 72147 103 120 731206 Nishito A. 40711 72 Nishiuchi T. 35711 76 Nishiya K. 1621329 Nishiyama F. 9146 Nishiyama K. 218128 75 Nishiyama M. 450139 Nishiyama S. 3011420 Nishiyama T. 1891904 Nishiyama Y. 20116 406138 617115 Nishizawa M. 71144 158111 Nishizawa Y. 462122 Nitta W. 58814 Nitta Y. 5891117 Niu F. D. 2561123 126 Niu X. 4071142 Niu Z. 406184 Nivoliers F.650156 57 Niwa H. 2971150. 151 Niwa M. 5201618 Niwa S. I. 184/505 506 Niwa T. 5201636 Niwano M. 5211689 Niyaz N. M. 475167 Njar V. C. O. 3841120 6031142 Njinkoue J. M. 1811179 Nobilec E. 514155 Noble D. 372183 55611 72 173 174 Nobutoshi N. 5221766 Noda M. 1871761 Noda Y. 4071119 Node M. 428170 Noe. M. C. 15818 159184 5891118 119 120 122 123 Noe R. 5171319 Noel F. 11143 Noel J. P. 1841484 492 493 25711 93 Noelte R. J. M. 5161293 Noguchi T. 4511168 5191561 Nogueira R. T. 1611239 Nogura M. A, 4071187 1-76 Natural Product Reports 1997 Nohara I. 5151156 Ocana F. A. 5161252 Ohnmeiss T. E. 97174 Okumura Y. 2571229 3011420 Nohara K. 2421166 Occi J. L. 450121 5551106 107 108 Ohno M. 109178 4081246 474122 Ohno T.5201634 Okuno S. 5221809 Nohara T. 731161 203130 40 Ochi M. 427120 5221796 635158 676145 Ochiai H. 1611208 Ohnuma S. 142185 Okuro K. 6361124 6181162 188 193 Ochiai K. 255156 Ohrai K. 1611216 Okuyama E. 475194 102 Okuyama H. 1431158 166 167 Nolen Jr. E. G. 428182 Ochocka R. J. 47418 Ohrui H. 1851595 Nolte M. 5201582 O’Connor D. 650147 Ohsaki A, 255173 177 203 204 205 1601124 125 Noltemeyer M. 1601150 Odajima T. 371138 Ohshima T. 721104 106 107 1621346 1871778 41 11458 Okuyama K. 1431168 Nomoto K. 428154 4631107 Oden P. C. 2421148 Nomura A. 1861655 Odinokov V. N. 5161304 Ohsuka S. 3321125 Okuyama T. 1861615 474141 Nomura M. 72150 514168 74 Odontiadis J. 4081281 Ohta A, 741276 65913 475182 5 171378 379 52 11661 662 Oehlschlager A. C.96133 Ohta M. 3321125 428182 Olano C. 555185 6361124 Oelrichs B. P. 91167 1601168 Ohta S. 142158 95 2981222 Olden K. 635127 Nomura T. 602155 56 Oelsen H. L. 4101381 5161273 5 171354 Oldfield A. 1811238 Nomura Y. 3851156 Oesterhelt G. 1811158 1871772 Ohta T. 1601193 2981202 5161298 Oldham N. 96126 Nonaka G. 71144 Oettmeier W. 20127 65018 24 Olesker A. 39145 109151 Noorwala M. 6781182 6791204 Offen P. 3011467 Ohtaguchi K. 1881882 Olias J. M. 1851557 559 1881867 Noriaki K. 406169 Ofterdinger-Daegel S. 5 161268 Ohtaki Y. 72150 Olimov V. 406162 Norin T. 513130 5211736 677182 5211714 5221768 Ohtani A. 72147 Oliva I. M. 1591102. 255116 Norman A. W. 3861216 Oganesyan E. T. 4751107 Ohtani I. 2981206 209 3011474 Oliveira A. B. 2561122 Normansell 1. D. 3321164 Ogasawara K.7311 79 159176 89 Ohtani I. I. 428194 Oliveira E. 5221792 Normant J.-F. 6361120 90 4291112 5181460 589185 95 Ohtani K. 731148 255160 2571206 Oliveira F. M. 475155 61712 Norrby P.-O. 5891121 651199 117 659111 5221784 677156 57 6781147 Oliveira-Campos A. M. F. 589168 Norris D. M. 97178 Ogasawara N. 255176 Ohtani M. 4511149 Oliver J. S. 1431148. 150 Norris J. N. 1811169 296179 Ogata K. 635183 6781191 Ohto C. 142185 Oliver R. M. 3571145 Norskov-Lauritsen N. 71124 Ogata T. 463149 Ohtomo H. 3861228 Oliver R. S. 3321146 147 Norte M. 5561146 152 Ogawa K. 1851586 3311115 Ohya, K. 5901133 Oliver-Smith D. 589165 Norton K. 241123 53 2431195 Ogawa N. 255176 Ohya Y. 109135 Oliviera E. R. 5171389 Nose M. 72191 Ogawa S. 1611208 408/242 4511146 Ohyabu N. 2981182 Oliw E.H. 1801135 Notaro G. 2971123 Ogawa S. 651191 103 Oi S. 142176 Oliynyk M. 450120 Nour M. 1841492 Oger J-M. 514194 Oikawa H. 5561184 Ollivier E. 6791234 Nourse P. N. 602178 Ogeto J. O. 20116 406138 617115 Oinuma H. 463141 Ollivier R. 4101397 Novak I. 5191568 569 Ogibin Y. N. 3851154 Oishi T. 39131 Olmsted S. L. 4081249 Novelli A. 109180 Ogihara Y. 72191 Oiwamoto M. 741253 Olsen C. E. 911124 125 721121 Novgorodova N. Y. 6511100 Ogiku T. 721101 116 120 176 191 Ojala W. H. 4081247 731125 141232 233 234 5221799 Novotny M. 1861657 199 206 4291126 Ojida A. 5181482 6781192 Nowak D. 4101402 Ogilvie R. T. 401109 Ojika M. 3001402 404 405 406 Olsen J. E. 2421145 Nowogrocki G. 635133 Ogimi C. 5221786 407 4641116 Olsen J. G. 35516 Noyori R. 428140 51316 Ogino T. 6191212 Ojo B.20151 Olsen R. L. 1881843 51 61298 5201618 Ogino Y.,9141 10185 86 Oka K. 11134 Olson E. C. 450178 Nozaki H. 731131 291189 2991275 Ogita T. 463197 Oka S. 2191100 Olsson B. 1811201 Nozaki Y. 331156 O’Grandy E. 1861687 Oka T.-A.,1431216 Olsson M. J. 1441242 Nozawa A, 3011428 Ogrel A, 218121 Okabe K. 650136 Oltra J. E. 1601194 1611217 Nozawa K. 4751121 Oguntimein G. B. 5161283 Okabe M. 3861220 5 151167 Nozoe S. 1601193 2981202 617110 Ogur T. 1591115 Okabe N. 618139 Omar S. 2981197 6 18177 78 65018 24 Ogura K. 142159 60 61 70 71 72 Okada G. 296138 428162 Omar S. M. 4091287 Nuccio M. L. 356166 73 74 1431136 137 138 139 Okada K. 9140 3011486 406143 O’Mathuna D. P. 255129 30 31 Nue H. 330131 15815 6 428160 449111 12 450113 589190 Omori S. 731127 401113 5211722 Nuhn P.1841464 Ogura K. 602136 82 83 84 85 95 Okada M. 72170 141218 Omote K. 9124 47 57 Nuho Y. 731161 60311 04 Okada N. 5211689 Omoto T. 5171355 Nukaya H. 3011428 Ogura M. 2971103 Okada Y. 1821266 474141 475182 Omura M. 20153 54 55 56 415164 Nukina M. 9121 Ogura Y. 159180 3001336 46217 9 463128 618169 70 72 75 Nukui S. 39119 Oh H. J. 411160 Okaishi Y. 731189 1881848 Omura S. 109189 90 159142 Numai T. 4101387 Oh S. H. 3851187 Okajima H. 1821266 3571149 372192 428180 100 Numata A, 296139 40 41 42 O’Hagan D. 180184 1841456 Okami Y. 296129 Omura S. 450114 16 4511149 156 298121 9 428154 63 463194 104 1881822 35511 11 371110. 12 13 Okamoto J. 1861641 167 554130 555189 5561188 107 513120 618157 58 55312 8 5561185 Okamoto M. 741240 3851197 Oiiaderra M.3571184 Numazawa M. 384141 113 118 Ohashi K. 474122 K. 5171311 4081246 Onbeowiak J. C. 109169 Nunei C. S. 4511141 Ohashi M. 72177 Okamoto N. 9116 47 Onderka D. K. 450132 Nunogaki K. 1851580 Ohashi T. 1441249 Okamoto Y. 1621335 475194 Ondra P. 4101442 Nunogaki Y.. 1851580 Ohba M. 2991297 5211730 Okamura H. 97193 1611266 O’Neill B. C. 218118 Nurkenov 0. A, 401146 147 Ohguchi A. 72174 75 2571202 2581232 3001346 677176 O’Neill M. J. 255122 635193. 94 Ohi K. 474122 85 86 88 Ong A. 180163 Nussbaumer. A. 331177 Ohigashi H. 158136 Okamura K. 2991297 5191567 Onishi S. 20155 Nutsu K. 513135 Ohira M. 514161 Okamura W. H. 3861216 217 Ono H. 71119 142172 331156 40512 Nutt J. G. 4081207 Ohira S. 297189 659114 Okano K. 513116 Ono M. 96134 159180 3001335 Nutt R. F. 8116 Ohira T.514161 Okano M. 4751117 677192 93 95 3001336 406169 4081225 5 181428 Nuutinen L. 4081277 Ohishi H. 296141 428141 4631104 Okano T. 1841507 5181432 Ono T. 618173 Nuzillard J.-M. 82126 47 58813 618157 Okasha S. 4091306 Onodera R. 4071192 Nwosu C. V.. 1881857 Ohizumi Y. 731163 296167 68 Okazaki H. 331156 Onorato E. 2561130 Nyasse B. 218138 2971146 2981202 2991294 463139 Okazaki T. 46219 Onorato M. E. 255133 35 Nylander I. 4091349 353 79 650124 651170 O’Keefe D. P. 1421113 Onose R. 428162 Nystrom G. J. 5561161 Ohkata K. 5181428 Oki T. 555160 61 62 63 64 65 Ontsuka H. 1611242 Nystrom J. E. 1821299 Ohkawa H. 1431145 66 5561128 Onur M. A. 72178 303110 I1 Nze-Ekekang L. 6791234 Ohkawa K. 981183 1611224 Okino T. 2581241 2991280 428153 Ooishi Y. 6791245 Ohkubo M.4291107 Okorn D. M. 4101376 Ookawa N. 741214 Ohkubo T. 1611270 1621328 Oksuz S. 2571216 Oosterhaven K. 5 171370 2991279 Oksiiz S. 1621304 677153 Ootsu K. 450181 Ohlani K. 6781132 Oku A. 5181440 Oppolzer W. 218135 36 39 40 44 Oba M. 218128 75 Ohlrogge J. B. 1811148 35518 Oku H. 635124 45 49 450176 5201650 651178 79 Obata S. 142159 60 61 3571137 157 159 161 166 174 Okubo K. 6771119 80 175 180 Oppong I. V. 677168 Oberhansli W. E.. 2991290 Ohmiya S. 40198 141 Okuda H. 475150 Oberti J. C. 1601190 Okuda O. 2561131 132 Orahi K. Y. 1601136 Obitz P. 371148 Ohmizu H. 721115. 116 731176 Okuda R. 9144 Orallo F. 4071190 O’Brien E. 5561187 178 191 192 199 206 Okuda R. K. 3011490 Orduna A. 5 181483 O’Brien P. 6361118 Ohmoto S. 4291110 Okuda S. 3571148 450155 65 O’Reilly J.M. 3841122 O’Brien P. A, 39123 Ohmoto T. 428165 677194 Okudaira M. 463190 93 450137 38 Oreja E. 5201621 O’Brien S. 41 11460 Ohmura E. 203140 39 Oreski B. 5901136 Ocampo A, 301/439 Ohnishi S. 677192 Okumura K. 1851586 587 Organisciak D. T. 1851525 Index of authors cited 1-77 Oriaku E. T. 3851147 Ozarslan O. 5181437 Oriala J. 462113 Ozawa R. A. 3581201 Orians C. M. 97162 Ozawa S. 731127 128 133 741237 Oribe M. 1841516 244 263 Oriente G. 296181 297196 Ozqelik H. 20219 Orihara Y. 5171339 5191560 561 Ozden T. 401105 5211668 Ozek T. 5141113 5151188 191 193 Oritani T. 1431183 158134 35 199 200 219 222 5161224 231 Orito K. 7311 74 175 384175 232 248 5171353 Orjala J. 296147 52 5171348 Ozen H. C. 5211687 Oron Y. 4101425 Orozco M.30319 Orr A. 474128 Orr B. 741229 P Ortea J. 3001408 Ortega A. 1601186 1611207 211 256194 6771121 Pacciaroni A. del V. 1601190 Ortego F. 5161259 Pace R. 2571152 Ortiz B. 159185 Pace-Asciak C. R. 179140 1801127 Oruganti R. 2571182 Pacey M. S. 5551112 Ory J. P. 406148 Pachaly P. 474127 5221791 Osa T. 411157 Pacifici R. 4091318 Osabe M. 142159 Packer L. 180163 Osada H. 296138 428162 Packman L. C. 555168 Osagie A, 401123 125 Patzel M. 428177 Osawa E. 1601151 5181482 Padha N. 475148 Osawa K. 1621337 Padilla A, 5561146 152 Osawa M. 5181442 Padmkumari K. P. 5171368 Osborn R. W. 981167 168 169 Padnikar S. K. 159183 Osborne M. G. 6031142 Padolina W. G. 1601183 Osborne N. F. 3311122 Padwa A. 731190 589193 Oshibe M. 3841113 3841118 Paetow M.401150 152 Oshima K. 255176 Page J. W. 331158 121 Oshima M. 450164 Page P. C. B. 5201649 Oshima Y. 2971167 3011427 Page S. W. 1861688 Oshino N. 3581233 Pagliarin R. 5201597 628 Osifchin E. 4101375 Pai B. R. 731149 Osman S. F. 1811221 1821306 Pai J. 6781198 1871719 Pai J. K. 159148 2991249 Osman S. M. 1821260 1831337 394 Paik W. H. 4751100 404 428 1841430 433 434 435 Pailo M. de Q. 405130 442 Pain G. 5181418 Ossipov M. H. 4081274 Pairas G. 3861242 Oster M. O. 241136 Pais M. 405125 Osterberg E. 1881823 Pais M. S. S. 5151195 Ostlind D. A. 109148 50 Pays M. 81/13 14 16 82154 58,71 Osuga H. 5201620 622 Paiva N. L. 141136 450143 47 O’Sullivan B. M. 39120 97156 555196 98 99 6511113 Pajunen A, 72158 O’Sullivan J. 3331204 Pak H.H. 513132 Osumi K. 2971125 Pak Y-P. 5181433 Otaka N. 1601203 44917 8 9 Paknikar S. K. 47415 4751119 Otani M. 4511149 5 171352 Otani T. 5171378 731132 Pakrashi S. C. 1811184 Otani Y. 6361129 Pal B. C. 635166 6781134 O’Toole K. J. 218190 91 Pal S. K. 1601146 Otsuka H. 158115 16 2561127 Palacios P. S. 475189 5 161267 5221770 771 786 Palagiano E. 3011476 479 481 6031103 Palazzino G. 741274 589153 Otsuka M. 109178 Palibroda N. 217116 Otten S. L. 553118 Palic R. 5161225 Ottenheijm H. C. J. 2981186 Palinkas J. J. 5141100 Ottow E. 3851144 427130 Pallavicini M. 1861643 Otvos F. 4081236 254 255 Palme M. H. 5201588 OU B.-X. 6781171 OU,J.-C. 6791208 Palmer C. J. 475169 Ouafik L’H. 4091364 Palmer N. J. 218181 Ouchi T. 109135 Palmer R. A. 383111 32 Oulad-Ali A.6781180 Palmisano G. 2581242 428143 Oursel A. 1871785 475198 618130 Ouyang Y. 428165 Palo R. T. 97157 Ovek T. 5151144 Paloma L. G. 109165 1811213 Overkleeft H. S. 635129 2981179 3011477 481 4641115 Overman L. E. 40187 2971126 Palomino P. L. 5171312 2981210 3001366 463147 Palomo C. 5201623 644 Overman L. E. 635142 651194 Palovinka M. P. 1591109 Overton J. 981191 Paltauf F. 180180 3571141 Overton K. H. 602139 40 57 Pamboukdian N. 6511111 Owen D. 2561144 Pampusch M. S. 4091311 Owen D. J. 2421159 Pan L. T. 2561126 Owen E. 3571124 Pan T.-M. 741212 Owen E. S. E. 5551123 Pan T.-Y. 618177 78 Owen H. 4081281 Pan X. 2561146 5201654 Owen N. L. 1611276 589180 Pan X.-F. 635118 19 6771109 6781196 Pan Z.-F. 39129 Oya N. 58814 Pancrazi A.6361101 Oyama N. 2421165 168 170 Pandey D. P. 677161 25 611 44 Pandey G. 635190 Ozaki T. 303115 Pandey H. S. 6791221 1-78 Natural Product Reports 1997 Pandey V. B. 8114 82122 24 25 27 28 29 30 31 32 34 60 677161 6781184 Pandit U. K. 303122 428178 635129 Pang D. W. 4071143 Pang G. 39153 Pang G.-L. 65913 Pang G. P. 4081219 Pang Y. 406193 Pang Z. 1431176 1811219 1821254 4071127 137 139 Panigot M. J. 219195 Panneerselvan K. 475151 Pannek J.-B. 427112 Pannell C. 97169 Pannell L. K. 2571227 3001358 Pansegrau P. D. 4511119 Pansini M. 2981234 235 299131 9 Pant A. K. 5151146 Panter K. E. 39124 39 203123 635125 660178 Pantke-Bocker S. 297186 Pantoleo T. 4101380 Panu A. M. 202110 Paolillo L. 1871728 730 Paolucci C.659112 Papageorgiou A, 3861242 Papageorgiou G. E. 1851519 Papaj D. 971112 Papastergiou F. 255123 Papazoglou G. 372167 Pape H. 372182 4511151 Papeo G. 428143 Papin N. 741257 258 Papke T. 2981203 650125 58 Paquete L. A. 158131 1621320 255139 2971100 118 3001401 5191509 5201599 600 635134 65 1195 96 Paradkar M. V. 474133 475157 Paradkur A. S. 3321190 372170 Paranhos A. 474114 Pare P. W. 72154 Parish C. R. 39150 51 Parish E. J. 3831843 Park B. B. 618136 Park C. M. 3001396 Park C. Y. 5161290 Park H. 2571192 Park J. C. 202112 Park J.-D. 9131 Park J. G. 4751100 Park J.-G. 63415 635131 Park J. H. 82121 Park J. N. 4081228 Park K. 159164 2991256 Park K.-H. 9131 45 51 Park K. S.618124 Park M. H. 82121 41 Park M. K. 741260 Park P.-u. 462115 Park S.-H. 1421103 104 5171365 Park T. K. 3851184 185 Park W. M. 5201641 Park Y. B. 3851187 Park Y. G. 2571169 Park Y. S. 6361106 Parker C. E. 1801117 Parker J. 35519 55319 Parker L. A. 4091366 4101367 Parker W. L. 331153 Parkin K. L. 1851601 Parlow J. J. 5211707 Parmar V. S. 721121 731125 144 741232 233 234 Parodi A. J. 39134 371112 Parra A. 1611260 255133 2561130 Parry A. 981184 Parry A. D. 981202 141114 Parry D. L. 3011443 Parry R.J. 218171 4521189 Parthasarathy M. R. 741256 Partho P. D. 97195 Partington E. T. 1831410 Partis R. A, 635138 Parveen M. 4751120 Parvez M. 3861231 5201583 Paryzek Z 384182 Pascal Jr. R. A. 1831423 424 3571125 126 Paschke C.1601150 Pasha M. K. 1831342 1841442 Pasqual M. 4071132 Passacantilli P. 5221787 Passaniti A. 635138 Passarella D. 589158 81 91 Passeggio A. 3011422 423 Passreiter C. M. 1601185 Passreitter C. M. 255114 Pasteels J. M. 96111 18 618126 6361132 650155 659143 Pasternak G. W. 4081266 Pastuszak I. 39116 Patel D. 4081239 240 Patel D. J. 108116 109140 42 62 70 Patel M. 2991249 Patel M. G. 4291129 6781198 Patel N. 3311111 Patel N. A. 4091321 Paternostro M. P. 1601195 Paterson I. 29811 71 5191548 5561201 Pathak A. K. 71120 1601137 38314 7 Pathirana C. 3001340 462110 Pati H. N. 741234 Patil A. D. 1841446 2981207 463173 Patil P. A. 10195 Patir S. 589166 Patissou J. 4641115 Patnaik G.K. 3841110 Paton R. M. 1831403 Patra B. 3861237 Patra D. 513112 Patrick G. L. 2421168 Patrick J. B. 450183 Patrick M. 39122 Patrick M. S. 39121 635115 Patsalides E. 1841509 Pattanaprateep P. 3851203 Pattenden G. 3011444 Patterson G. M. L. 553111 555190 Patterson G. W. 463174 Patterson H. B. W. 180144 Patton S. 450135 Paul E. G. 8118 Paul G. K. 296162 Paul J. M. 5201626 Paul V. J. 1611231 2971115 Paula V. F. 741238 Paulsen H. 6361100 Paulsen R. E. 4101395 Paulvannan K. 463148 Pauly G. 1431135 Pavlek Z. 4081253 Pavlovic V. 384173 78 Pawlak J. M. 3851189 Pawlik J. R. 2981201 3571120 55611 42 Paya M. 2971110 Payne D. J. 3311116 Payne G. A. 5561161 162 Payne J. A, 5141119 Pazirandeh M.3581208 Pchelkin V. P. 1851577 578 Pearce C. M. 97167 Pearce D. W. 2421143 Pearson M. J. 33019 Pearson W. H. 40192 303124 Peat A. J. 4641117 Pecchi S. 5191534 Pechulis A. D. 3021495 3851169 Pecnik S. 1881845 Pedersen C. N. 1831418 Pedersen M. 463186 Pedersen S. B. 1881814 Pedone C. 2991278 Pedreros S. 255149 Pedro J. R. 731153 1611240 243 1621300 Pedro L. G. 5141101 Pedrosa R. 218135 Peerless A. C. J. 371114 15 Peeters A. J. M. 1441225 2421123 Peeters P. 30319 Pegram J. J. 158110 Petasis N. A. 1801126 Pidacks C. 450183 Plotkine M. 4091286 Pehk T. 217110 11 3571129 Pete J. P. 5201615 Piepponen T. P. 4091354 Plourde G. L. 2991295 Pei Y. H. 474145 46 Peter H. 331175 Pierce H. D. 96133 Plugar V. N.1821263 618163 Peiser G. 158138 Peter H. H. 4281102 4291121 Pierce T. L. 4101369 Plumet J. 1831383 Peiser C. D. 1421112 Peters A, 296185 Piercey J. E. 5561174 Plumet M. H. 4101411 Pejanovic V. M. 383128 384190 Peters A. F. 297186 Pieri F. 4751105 Plummer J. L. 4081281 Pelaez C. 981186 Peters B. M. 2971159 Piermatti O. 5211664 Plunkett A. O. 65011 Pelaez-Lamamie de Clairac R. Peters D. D. 618150 Pierpoint C. 1821314 Pluzhnikov V. A. 5171387 71I36 Peters J. P. 3917 Pierrot M. 1601142 Pniewska B. 383123. 27 Pelczer I. 1611250 Peters T. L. 109192 Piers E. 2991295 Poch G. K. 463189 92 98 Pelissier Y . 5 14/95 Peterson A. 109191 Pierson 111 L. S. 372163 4521184 Pocklington W. D. 119121 Pelizzoni F. 616131 Peterson D. H. 450177 Piet D. P. 1601177 178 Podanyi B. 4071163 Pella Lucia T.M. C. 96132 Peterson J. K. 5111367 Pieters L. 741252 42711 7 Podesta J. C. 5181403 Pellegrini M. 25518 297194 Peterson P. K. 4091322 Pietra F. 1621350 1811236 1821241 Podojil M. 1851598 Pelletier G. 1871785 Peterson R. E. 1821304 305 2571207 208 296121 78 82 Poehlmann S. 4101418 Pelletier S. W. 20218 9 10 12 1891894 899 2981220 271 3001369 370 Poggi M. 4751115 203121 23 Peterson R. P. 110199 4101444 427116 463134 55 56 57 Pogrebnyak A. V. 4151107 Pelletier S. W. 20141 618159 Petiard V. 5211692 58 60 61 63 64 88 99 4641112 Pohlan S. 463154 Pelter A, 721112 113 114 119 Petithory J. R. 3581217 114 Pohnert G. 296184 297186 731137. 181 195 204 Petitprez M. 981156 Pietraforte D. 4091318 Pohost G. M. 1861697 Pen X. 616115 Peto C. A, 10196 Pietro F.46211 Poirel C. 5181417 Peiia R. C. 635168 Petraglia F. 4101413 Pietrzak P. 401136 Poirier D. 38315 384171 99 100 Peiialva M. A, 312179 80 Petri A. 5891126 Pigge F. C.,6511109 Poisson D. 4751105 Peiia Rodriguez L. M. 6111101 Petricic J. 5161246 Pighini M. 463164 Poisson J.-F. 6361120 Penco S. 109124 Petrini M. 635110 Pihlaja K. 5191566 Pokorny F. 405129 Pendri A. 2511191 Petroski R. J. 3581196 Piironen V. I. 1851524 Pol O. 4081271 Peng G. 4081220 Petrovic J. 383128 Pika J. 2581235 2991303 3001415 Polach K. J. 218124 25 Peng H. 1611277 Petrovic J. A. 384190 3011468 Polasek M. 47419 Peng H. R. 1621292 Petrsen B. O. 428169 Pike M. M. 1861697 Polasek M. 428184 Peng J. 38318 Petrusieqicz K. M. 5181434 Pike R. K. 6511119 Polashock J. J. 35711 78 Peng J.R. 6111115 Petter R. C. 5891112 Pilati T. 2581242 421115 Polborn K. 3011453 5891108 Peng S. 4071140 141 Petterson D. S. 401130 Pili R. 635138 650111 Peng W. S. 5201612 Pettit G. R. 203127 28 29 Pillai S. 5201640 Poley C. S. 5221782 Peng X. 406176 Pettit 111 G. R. 30313 4 14 Pillai S. K. 2981213 Policastro P. P. 4521185 Pengsuparp T. 2511216 475173 Pettit R. K. 2981240 Pilli R. A. 39173 40195 65914 Pollak F. C. 16011 73 Penn N. W. 4081264 Petuch B. 5561176 Pilo-Veloso D. 256180 Pollaud G. 296175 Pennington A. J. 109147 Petzold U. 917 Pimenov M. G. 1621294 Pollini G. P. 650140 Penny M . 2431202 Peyri J. 41 11455 Pina I. C. 2571196 197 199 Pollio A, 182/244 Penrose A. 3321151 Pezzanite J. O. 463195 20115 72166 300134 7 348 Pollmann K. 6791236 Pepe C. 1871760 255122 2561125 2571216 4011178 Pina M.1881806 811 812 861 Polniaszek R. P. 40179 428142 Perales A, 1601204 1621326 25516 i9 4281104 475173 Pinard E. 2971100 651195 96 Polo E. I621300 70 2561128 Pezzuto J. M. 6791205 Piiieiro-Nuiiez M. M. 671191 Pomeroy M. 96117 Perani P. 555183 Pfander H. 158129 Pinel R. 514165 Pomilio A. B. 131158 650114 Peraza-Sanchez S. R. 6771101 Pfeffer P. E. 1811221 1871719 Pinette M. 4101418 Pomonis J. G. 1821300 Perdue M. H. 4101377 Pfeffer W. D. 602168 Ping L. 141274 Pomponi S. A. 2981242 2991249 Pereda A, 555149 50 Pfeilsticker K. 1871755 Pingal R. 203142 Ponce M. A, 5171380 Peredy M. K. 589187 Pfer H. 5211703 Pinheiro A. L. 677181 Ponglux D. 5221762 Pereira E. R.. 4291106 Pfister J. A, 39124 Pinheiro S. 721110 Ponnamperuma K. 1431207 Perelongo F..2561151 Pfister M. 414117 Pini D. 5891126 Ponsford R. J. 331187 88 96 Perera S. D. 5211671 Pflieger P. 1891902 Piniella J. F. 5201632 Ponzone C. 371136 Peres Y. 5181446 Pflueger T. 660158 Pink C. R. 6031141 Poolinski M. J. 255131 Pereyra C. 1861667 Pham L. H. 303112 Pinkerton F. D. 3851188 Poon M. K. T. 72151 Perez A. G. 1851559 1881867 Pham T. H. 5151148 Pintauro P. N. 1841502 Popa N. P. 514177 Perez A. L. 5171349 Pham V. K. 5141127 Pinter S. 1861621 Popescu G. 1441240 Perez A. L. 1601162. 659121 23 Phare N. A. 475156 Pinto A. C. 256179 Popjak G. 602170 80 81 Perez C. 731160 588113 Pharis R. P. 9159 2421143 I76 Pinto G. 1821244 Popkov A. A, 1811178 Perez J. 29811 79 Phife D. W. 159148 2991249 Pinto M. M. 255175 Popot M. A. 383115 Perez J.A, 72149 Philipov S. 4011179 4081216 Pinto Ricardo C. P. 39136 Popov S. 5191486 5221769 772 Perez M. G.. 384156 Philipp P. 96138 39 Piovan A. 47414 PopoviC M. 635166 Perez-Alonso M. J. 5151157 175 Philippe H. 46212 Piovano M. 1611230 256187 135 Poralla K. 356162 3571103 450116 179 Philippini C. 159154 474121 Piovetti L. 25516 8 297194 101 26 28 54 57 58 61. 66 67 68 Pkrez-Esteban B. 312180 Phillips A. L. 1441226 2421105 122 Pio~zi,F. 255164. 65 67 70 69 70 Perez-Lopez J. A, 40511 125 2431198 Pirani J. R. 131164 Pordesimo E. O. 2981238 Perez-Rodriguez I.. 4011193 Phillips R. S. 5161282 Pires de Lima D. 635165 Porreca F. 4101421 Perez-Soler R.. 109127 Phillipson J. D. 372158 59 Pis J. 731195 91191 3851204 Porte A. M. 6361126 Perfetti M. T. 1821319 Phinney B.O. 1441221 231 24011 Pistelli L. 4081218 475186 Porter E. A, 39158 59 96112 Pericas M. A, 5201632 7 241131 55 60 61 74 91 103 Pitel D. W. 2421174 Porter J. W. 602133 87 Periti P. 109180 2421127 128. 129 130 131 152 Pitkanen 0.M. 1841512 Porter N. A. 1851534 Perkins E. G.. 1831355 1851602 153 154 156 157 158 161 171 Pitlik J. 3331227 Porter R. B. R. 971102 1601127 1861618 619 620 621 673 173 177 178 179 183 2431193 Pittman Jr. C. U. 5191515 Portoghese P. L. 4081234 247 249 Perler F. 463131 194 196 199 2561139 142 Piulachs M.-D. 141119 20 27 4101419 421 Perlman K. L.. 3851142 Phuong N. M. 677180 Pizza C. 617158 Porzel A. 10199 101 102. 981173 Pernich D. J. 40186 Piacente S. 671158 Pizzarello A. 1821282 356182 203135 255126 Pernollet J. C.. 981157 Piatelli M.1621341 Pizzo F. 5211664 Poso A, 414113 Perrella D. 405110 Piatrelli M. 25515 2511203 296181 Pizzolato G. 1831368 Posorske L. 1881807 Perrett S. 20111 291190 96 97 Planchenault D. 12173 Poss A. J. 384168 Perrin J. L. 1861645 Piatti M. 555183 Planchuelo A. M. 401114 115 Post-Beittenmiller D.. 3511166 Perromat G.. 677166 Picasso S. 39117 33 635111 14 Plank C. 514172 Post-Beittenmiller M. A. 3571159 Perrone D. 651189 92 Piccialli V. 2971123 2991284 285 Plat M. 4071160 428187 Postels H.-T. 331176 Perrut M. 1861658 384144 Platt M. W. 406149 Posthumus M. A, 91184 87 Perry D. 635116 Picciano M. F. 1851602 Plattner J. J. 109191 2511174 Potacek M. 4011167 Perry D. N. 3851189 Pichersky E. 14 1/51 142191 92 Plattner R. D. 9123 981189 Potchen E. J. 1861698 Perry N.B. 71132 158122 5 1612 74 602198 1891893 895 899 3581195 Potgieter M. 4511104 108 109 Persson C. 4101393 Pichot W. 4071195 Platzer N. 39168 1861695 Pothier J. 401120 635179 Persson M. 5 13130 Picken D. 602139 57 Plazibat M. 5161246 Potier P. 159139 25711 77 65015 Perveen S.. 383121 Picker M. J. 4091298 Pleasance S. 1841448 Potnis P. V. 4071185 Pervez M. 202116 Pickett J. A, 96130. 31 97176 Plenevaux A. 2 19/98 Potter G. A, 3851135 Perz-Alonso M. J. 5161226 14211 13 I I4 Plessner T. 5891106 Potterat O. I621357 Pesic P. 5 I61225 Piclet G. 463176 Pliam N. B. 2571230 Potts A. 40514 Index of authors cited 1-79 Potts B. C. M. 2981207 3011467 Potts G. D. 20157 Pouler A. 371136 Pouliot R. 159182 Poullain D. 1841492 493 Poulos A. 180186 1821298,1841465 Poulos T.L. 555179 Poulter C. D. 141150 142166 67 68 69 77 78 79 86 87 88 371137 463130 602129 35 67 71 72 73 75 76 79 91 92 94 99 6031101 102 105 Poupat C. 159139 65015 Pour M. 2421165 2561145 Pournaghash S. 4101433 Pouzar V. 3851134 149 Poveda A. M. 5201621 Poveda L. J. 405135 Powderly W. G. 109196 Powell D. 3851165 Powell D. R. 2991255 Powell R. G. 981189 Power B. M. 401130 Pozetti G. L. 475187 Praange T. 5561190 Prabhakar S. 428172 Prabhakaran J. 3851163 Prabhakaran P. C. 1431159 Prabhanjan H. 10813 Pradhan A, 4751109 Pradhan B. P. 2561118 Pradhan P. 255159 Pradhan V. 4751109 Prager R. 65016 Prager R. H. 650160 Prakash C. 1841482 Prakash C. V. S. 1601176 1811209 3001337 Prakash O.20120 Pramanik B. 1821277 Pramod K. 1591105 Prange T. 384179 3851191 Pras N. 7115 35 Prasad A. K. 721121 125 741233 234 Prasad C. 6791221 Prasad R. 180174 Prasuna G. 5181458 5211729 Prates H. T. 5201587 Pratesi F. 109125 Prather T. R. 2971153 Pratt R. F. 3321134 Praud A. 25516 2971101 Praveen M. 20135 618143 Preiser F. A. 109148 Prelog V. 450176 84 Premachran U. 5561171 Prescot A. G. 3331219 Prescott A. G. 2431188 Prescott D. J. 356131 Presgrave 0. A. F. 514171 Presle L. 731142 Prestegard J. H. 356134 36 37 38 3571158 Preston C. M. 1841444 2971155 Preston K. L. 4101429 431 Previtera L. 741230 158118 1821244 6771110 Prevost J. 1861613 Prevot A. 1861645 Priano L. 4081204 Price D.D. 4081262 Priebe W. 109127 28 Priest R. 10816 Priestley N. D. 4521191 Prikrylova V. 428185 Prince M. E. 5181439 Principe P. 71125 Principe P. A. 331153 Probert J. 218118 Procter G. R. 741229 65918 Proctor R. H. 1431140 141 157 189 Prodger J. C. 10816 1621320 Proenca A. 474114 Profitt J. 602179 Proksch P. 401104 96119 20 53 61 2981229 635182 Prome J.-C. 356199 Pronzato R. 2991308 Props C. 40711 73 Prosser A. R.. 1861689 Protais P. 406179 4071197 Proteank A. T. 97185 Proteau P. J. 1821255 3571133 3581203 463165 Protiva J. 3851171 Protiva M. 38511 71 Protopopova M. N. 721111 Proulx J. 141138 Provis-Schwede A. 514198 Provost J. 3011476 Prudhomme M. 4291106 Pruess D. L. 331173 81 Pryce R.J. 240110 Pryor W. A, 1851532 1871774 Przemycka D. 971103 Przesmycka D. 1601165 Przewlocka B. 4091352 Przewlocki R. 4091352 Przybyl A. K. 401108 137 Ptaszynika K. 971103 1601165 Ptock A. 20121 428173 Pu H. Y. 202118 203119 Puar M. S. 20141 159148 1821277 202110 2991249 383124 4291129 6781198 Puchberger M. 5171308 Puchta V. 1821267 270 271 272 2 74 Pugh E. L. 3571114 Puglisi M. P. 553111 555190 Puig M. 4081271 Pujar G. S. 474116 Pulatova M. P. 255128 Pulatova T. P. 255128 Puliti R. 159151 2991257 258 309 311 Purdon B. 39152 Pusch F. J. 1861669 Pusset J. 20113 82136 617111 6 1812 7 74 65015 Pusset M. 65015 Puterka G. J. 971121 Putievski E. 514164 5161287 5 171357 358 5 191559 Putter I.330134 Py S. 25711 72 Pylkkanen L. H. 71140 Pyre B. J. 97176 Pysarevsky A P. 218179 Pyun H. J. 5191489 490 Pyun H.-J. 1421107 Pyun H.-Y. 142196 Q Q. Lin G. 4751116 Qauasmeh R. 1611256 Qi A. 406184 Qi Z. 406194 Qian L. 41 11461 Qian Z.-Z. 203130 635158 Qiang W. 1851526 Qiao L. 427124 Qiao X. 5201654 Qiao Z.-S. 677187 Qin B . 41 01372 47411 0 475179 Qin B. Y. 4101426 Qin G. 255137 676146 6781150 I70 Qin G-W. 4521190 475176 5211727 5221761 5561148 Qin W. Z. 1611253 256189 6771112 6791212 240 in X. 5141111 5151183 Zingying Z. 2971122 Qiu M. 203139 Qixin L. 474147 Qu A. 4071142 Qu X. 40514 Qu Z. 406176 Queckenberg 0. R. 30317 Queguiner G. 3011459 Queguiner G.,427127 28 29 650156 57 Queiroz E.F. 405130 Queiroz M. J. R. P. 589168 Quek W. L. 1611219 Quemard A. 356196 Quesada T. G. 731130 Quetin-Leclerq J. 58815 Quevauviller M. A. 82171 Qui Y. 29811 76 Quideau S. 72161 62 Quigley G. J. 108110 Quigley S. 109191 Quijano L. 971144 1601148 Quilici D. R. 96135 142194 Quilliam M. A. 1841448 296164 30 11427 Quinn D. M. 1831427 Quinn R. J. 1841445 2971121 Quinoa E. 1811218 2981197 30 1 I439 Quinones W. 981186 188 Quintero-Cortes L. 384150 Quinto A. M. 401128 Quinton P. 1821331 Quirion J.-C. 741227 428188 58817 12 37 6511102 Quiros L. M. 555186 Quiros M. 1871801 Quivy J. 3841104 Qureshi M. M. 82150 Qureshi N. 356194 Quyen L. 383117 R Raadstroem M. 40517 Raap J. 218120.21 78 2191111 116 117 118 Rabasco D. 5201621 Rabelink T. J. 4101386 Rabenhorst J. 331175 Rabiller C. 1871746 Rabinowitz M. H. 2981210 Rabot S. 371114 I5 Rada P. V. 4091360 Radbil B. A. 255142 Radcliffe R. W. 109188 Radeke H. S. 159165 2991254 Rademacher W. 241195 2431185 Radhakrishna P. 1831344 Radivoy G. E. 5181403 Radko C. D. 971116 Radwan S. S. 1811164 Raevski N. I. 218179 Rafaiani G. 2561151 25711 70 Raffaelli A. 71114 15 Rafferty J. B. 3571169 Rafik W. 428188 Ragaini F. 20119 Ragasa C. Y. 25513 Ragg E. 5561186 Raghavan S. 4281101 Ragnarsson U. 217110 11 12 13 218138 2191110 Ragunathan N. 40513 4 513126 Raguso R. A, 142192 5161274 Raharivelomanana P. 1611212 Raharjo S. 1841518 Rahbaek L.428169 Rahimizadeh M. 40182 Rahman A, 3001395 Rahman N. A. 3861216 Raikhel N. V. 981169 Raina S. 676112 Rainuzzo J. R. 1871732 Rainwater D. L. 356174 83 Raje P. S. 428132 Rajendiran C. 731149 Rajitha B. 4151110 Rajkumar A. B. 1801131 Rajnikant 618161 Rajnikant V. 475158 Raju B. L. 3001371 Raju K. V. S. 2571225 3001344 372 3011482 Raju N. P. 1871716 Rajzer D. 47418 Rakhimova B. B. 1621307 Rakoff H. 1841467 472 473 474 475 479 Raldugin V. A, 2571194 200 201 Rali T. 5 171348 52 11682 5221798 6771106 6791219 Ralph J. 72161 62 Ralphs M. H. 39124 Rama F. 513118 Rama Rao A. V. 383130 Ramirez A. 588143 44 Ramachandran V. N. 618133 Rama-Devi T. 741275 Ramadoss C. S. 1861696 Ramaiah P. 158110 Ramalingam K.2191108 Ramamoorthy T. P. 255171 2561104 Ramana D. K. 405128 Ramana M. M. V. 4071185 Ramaswamy S. 96133 Ramchran P. V. 5191543 545 Ramesar N. 741245 Ramesh S. 5151159 185 Ramji N. 1601191 Ramner V. V. 5181448 Ramos J. M. 159159 3001411 Ramos-Valdivia A. C. 602164 89 Rampersaud A. A. 3851189 Ramphal J. Y. 1801126 1821312 Ramsden J. A. 5181404 Ramsden J. D. 981179 Ramser M. N. 428177 Ramsey A. J. 3581244 245 Ramsey D. L. 5171376 Ramsey L. M. J. 97164 Ramsey T. M. 109179 Ramsey U. P. 463170 Ranaivosata J. L. 1611263 Randall S. K. 60115 Randhawa Z. I. 3581206 211 Rando R. R. 1441245 246 Randrianarivelojosia M. 589157 Rang D. D. 514188 89 90 116 117 Rangan V. S. 3581206 Ranheim T.1831419 Rani K. 1431165 Ranieri R. L. 4511141 Ranzugliz P. 25611 51 Rao A. B. 5171336 Rao A. V. R. 1821311 325 405128 Rao B. B. 6791226 Rao B. R. B. 5151159 Rao B. V. 1831340 2571225 Rao B. V. S. K. 1821286 Rao B. Y. 1881825 Rao C. B. 159196 3001371 Rao D. V. 159196 Rao G. P. 5171368 Rao G. S. R. S. 1591105 Rao G. V. 3001343 372 3011482 Rao J. V. 2981245 Rao K. 384155 Rao K. M. C. A, 2571210 226 3001360 Rao K. N. 2571226 Rao K. V. 2571182 Rao M. 406194 Rao M. K. 4751110 Rao M. N. 475199 Rao P. 3851165 Rao P. B. 5211729 Rao P. D. 588135 Rao R. B. 6781127 Rao S. 5171386 Rao S. M. 1821329 Rao S. P. 72180 84 2571153 Rao S. R. 3001387 Rao T. C. 1841508 1861674 Rao T. P. 2991310 Rao U.M. 3861235 Rao V. U. M. 3861236 Rapaccini S. 5891126 Rapala J. 371117 6511122 Raper C. 4101369 Raphael R. A. 159154 474121 Rapoport H. 81111 18 650142 Raposo M. M. M. 589168 Rapp M. 4291106 Raquet X. 330129 Rasazza J. P. N. 5171340 Raschke T. 1601128 Rasco B. A. 1861692 1-80 Natural Product Reports 1997 Rascol O. 4081206 Reed J. R. 3581197 Reynaud D. 1801127 Rios J. J. 1851557 559 Rasheed T. 41 11462 Reeder A. Y. 3851145 Reynolds K. A. 3561102 3571111 Rios M. B. 4111460 Rashid M. A. 159197 1621333 Rees H. H. 10188 112 450125 26 27 33 34 35 49 Rios M. Y. 5141123 618129 2971130 2991328 3011440 Rees S. B. 981168 169 50 55318 5551103 Riou D. 3011481 Rashid N. 383120 21 Reese P. B. 911102 1601127 Reynolds W. F. 159173 85 203142 Riov J.981196 Rashkes Y. 4751118 Reeve A. J. 4081261 2971148 3001333 361 381 650154 Ripel E. 4101400 Rashkes Y. V. 1821262 263 296131 Reeve D. W. 1841457 67614 8 677169 Ripka S. 3571151 5561156 6 18132 Regan A. C. 650134 Rezanka T. 180185 1811187 188 Ripperger H. 141239 203135 41 Rashkes Y. W. 3011448 Regen S. L. 3851170 189 190 223 1821275 1851598 Risbridger G. D. 3331200 Rashkes Ya. 6781185 Reger H. 40191 612 614 Risdahl J. M. 4091311 357 Raskkes Ya. V. 405131 Reggio P. H. 5221812 Rezende C. M. 256179 Risk M. 296172 Rasmusen H. 4081279 Regimbal J-M. 514180 Reznicek G. 6781157 Rispens M. T. 5181409 Rasmussen B. A. 3311118 Reginato G. 5191534 Rhee J. S. 1851594 1871795 Rissanen K. 51915229 5201659 Rasmussen L. E. L. 96140 Regnault-Roger C. 514165 Rhee Y.H. 12197 Rissom B. 1601150 Rasoanaivo P. 20110 589153 57 Regnier A. 2015 Rhein F. Q. 4081280 Ritchie G. A. F. 555191 124 125 6781194 Rehfuss R. 109169 Rhiens G. 1601131 Rittammer R. A. R. 3331217 Rassu G. 39110 63413 Rehman H. 5171336 Rho J.-R. 2991312 3001383 Rittner R. 5191563 Rastogi V. K. 741256 Rehnberg N. 731139 Rhodes R. E. 330144 Ritzau M. 5561132 Rasulova K. A. 61716 Reibenspies J. 218132 Rhodes S. H. 1851591 Rivalle C. 20158 618179 80 Ratcliffe R. W.. 330144 Reibman J. 41 11452 Riba M. 3581198 Rivas F. 1611260 255134 Ratet N. 372191 Reich S. D. 10819 Ribar B. 383125 Rivett D. A. 2421183 Rath N. 635182 Reichelt J. L. 46211 7 Ribeiro A. A. 2991288 289 Rivory L. P. 5901134 Rathnum M. L. 331153 Reichenbach H. 553110 617120 Ribeiro C. M. R.5181447 Rizwi I. 3321136 Ratledge C. 1821283 356197 98 Reichert H. 5181472 Ribiero L. P. 5181411 Rizzacasa M. A. 405126 27 602143 Reid G. 218118 2991305 Ribon V. 3321156 Rizzi G. 5201597 Ratnayake M. 5171369 Reid J. B. 241183 2421135 136 Ribot E. 1861613 Rizzo C. J. 450114 Ratnayake W. M. N. 1811201 Reid J. S. 10180 Ricci A, 5191534 Riuo J. D. 475172 1861675 676 687 690 Reid L. D. 4101421 422 Riccio R. 1811213 296118 Rizzone M. 4081204 Raub M. F. 3011435 6361130 Reid R. G. 218119 67 2981223 2991266 3011476 477 Roach P. L. 2431190 3321189 Raudot V. 141122 Reid R. T. 296133 479 480 372174 Rauf A. 1831394. 405 428 1841433 Reif H. J. 981171 Rice D. W. 3571169 Roay R. 3841123 434 435 442 443 Reif 0.W. 1881839 Rice J. W. 109/75 Robards K. 1841509 Rauscher J.5151146 Reil E. 20127 Rice R. E. 96137 Robert J. 5901134 Ravelo A. G. 5211684 6791209 210 Reilly E. M. 4751106 Rice W. G. 3851178 Roberts B. E. 1611214 Ravelomanantsoa N. 20110 Reimann E. 4071121 Rich A. 108110 3581246 Roberts B. P. 514179 Ravichran R. 5181435 Rein K. S. 296170 Rich P. R. 20127 Roberts D. 428168 Ravid U. 514164 5161287 Rein K. S. 463140 Richard B. 82147 Roberts G. A. 356176 555169 5 171357 358. 5 191559 Rein T. 1821320 Richards R. W. 240114 Roberts J. D. 635127 Ravikumar K.. 383130 Reina M. 1601153 202111 58819 Richardson C. 97165 Roberts L. M. 5561157 Ravinchran R. 5201578 Reinecke T. 5561198 Richardson D. C. 356133 Roberts L. R. 5201657 Rawle N. W. 1851597 Reiner J. 474129 Richardson D. R. 971143 Roberts M. A. 463165 Rawleigh J. M. 4101437 Reis F.A. M. 81115 Richardson G. R. 1431184 185 Roberts M. F. 372158 59 4071150 Rawlings B. J. 110197. 55311 555168 Reisch J. 20160 42716 618133 Richardson J. S. 356133 450143 47 555196 98 99 Rawlings N. D.. 330127 Reisener H. J. 981195 Richardson P. F. 1881884 Roberts S. M. 1881884 Rawlinson N. S. 3321168 372171 Reis F. de A. M. 58816 Riche C. 39145 2571172 Robertson L. E. 41 11460 Ray J. A, 741256 Reish J. 474143 Richheimer S. L. 741266 2561107 Robeson D. J. 5561189 Ray J. E. 741254 Reissig H.-U. 635120 Richi C. 159139 Robien W. 1611259 1621309 Ray R. 3861223 Reith M. 3571139 Richli U. 1871754 5 171328 Ray S. 3841123 Reitz R. C. 3581197 Richmond M. H. 330120 Robin J.-P. 71125 26 72172 73 Ray S. M. 296172 Relafio E. 3571184 Richomme P. 514194 677166 Robins D.J. 401100 659119 20 Ray T. K. 356159 Remy F. 405125 Richter M. 5191518 Robins R. J. 311110 12 13 14 15 Rayle D. L. 10181 Ren J. 5201585 604 Richter W. J. 451194 Robinson C. H. 3841120 Rayner A. C. 5171343 393 Ren Q. 5151163 Rick C. M. 203147 Robinson D. R. 241128 29 Raza S. M. 6771124 6781125 Renaboles M. D. 3571185 186 Rickards R. W. 451199 100 101 Robinson H. 109118 19 20 Razakova D. M. 618132 Renard G. 1881811 102 103 I42 Robinson J. A. 3917 8 3321160 Read G. 1881884 Renard P. 428131 Ridell M. 356185 4521196 55511 I7 Read J. S. 1881863 Renard P-Y. 5181417 Rideout H. 4091366 Robinson P. D. 635131 Read R. W. 741221 2571198 Renata E. 2571185 Rideout J. A. 2991329 3011454 Robinson R. W. 1621312 3001345 651187 Renaud J. 2571183 463148 428186 Robles M.1621318 Reading C. 33012 36 331157 60 Rench L. 2191105 Rieck A. 1601147 1611218 1621342 Roblot F. 405130 85 3321129 130 131 Renger B. 1851582 Ried L. D. 4091292 Robredo L. M. 635167 Ream J. E. 4511119 Renhowe P. A. 2981210 463147 Riedel A. 142156 602151 Roby J. 6361107 Reamer R. A. 3841129 Renner L. 3571142 Riedel M. 5171319 Roby M. R. 650129 Reardon J. E.. 602162 100 Renoux B. 5181471 Riedl I. 1871722 Rocca P. 3011459 Rebachyk N. M. 3011448 Rentsch D. 61717 Riedner U. 1821278 I831370 Rocca P. 421127 28 29 Rebbolledo F. 1871801 Renwick J. A. A. 971104 110 115 Riendeau D. 71146 1821293 Roccatagliata A. J. 3011478 Recasens C. 4101411 116 Riera A, 5201632 Rocchiccioli F. 81114 Recchia P. A, 218124 Renz H. 4071121 Rigby J. H. 6511109 Rocco C. 2571203 297197 Rech R.H. 4101401 Repke K. R. H. 3851172 Righi P. 513118 Rochet P. 5181413 Rech S. B. 588/40 Rescifina A, 65917 Riguera R. 2981197 3011419 439 Rock C. O. 355110 28 29 45 46 Rechka J. A, 463180 Resende M. L. V. 981179 Rikimaru M. 109172 47 3511163 Redaelli S. 109124 Reshetilova T. A. 20117 Rikuta K-i. 5201593 Roclofs W. L. 96140 Redden P. R. 187/804 Resnat G. 384163 Riley A. L. 4101433 Roddick J. G. 10174 75 76 Reddy A. S. 1821330 356166 Respaud M.-J. 677190 Rilk R. 158114 Roden B. A. 651195 96 Reddy E. R. 180195 1821311 Retamar J. A. 5211680 Rilling H. C. 602177 99 6031116 Roder E. 2571157 Reddy G. D. 635190 Retey J. 4521196 Rim K. S. 513132 Roder H. 3011493 Reddy G. V. 2971145 Retsema J. A. 3311105 Rimando A. M. 72166 Rodewald U. 5211672 Reddy J. P.741255 Reunanen M. 5151210 Rimanoczy A,,4091302 Rodfer J. S. 4101437 Reddy K. L. N. 1821323 Reutel I. 82155 Rimoldi J. M. 1441255 Rodger C. 384162 Reddy M. M. 383130 Reutrakul V. 72166 Rimpler H. 731185 Rodrigues P. J. 405124 Reddy S. M.. 4751110 Reuveni R. 514164 Rinehart J. T. 1851608 Rodriguez A. D. 2571196 197 199 Reddy S. P. I821323 Revill W. P. 356132 3571108 109 Rinehart Jr K. L. 450174 78 204 217 223 29611 7 3001347 Redei G. P. 10198 110 451190 105 107 108 109 152 348 353 367 368 Reder E. 650119 Rewcastle G. W. 2991331 153 555188 Rodriguez A. 158133 Redlich H. 1601157 Reyes D. 660149 Rinehart K. L. 296124 2971166 Rodriguez B. 1621343 Redline R. 3581234 Reyes E. D. 1811199 234 250 3011446 475 372189 Rodriguez B. 255164 65 67 69 70 Redman A. M. 5171306 Reyes H.R. 1871790 Ringe K. 1621347 256193 Reed A. R. 2981177 Reyes M. 2991326 Riordan P. D. 651166 Rodriguez C. 5141123 Reed J. K. 462111 Reyes R. 2561121 Rios C. T. 1601148 Rodriguez E. 1621318 Index of authors cited 1-81 Rodriguez F. 6791210 Rodriguez G. 4011159 Rodriguez I. 1601194 1861695 Rodriguez J. 3011419 Rodriguez J. B. 5 171380 Rodriguez J. G. 1601204 1621326 1811175 234 Rodriguez M. S. 384180 Rodriguez-Hahn L. 255145 71 2561105 Rodriguez-Manzo G. 4101409 Rodriguez-Sasiain J. M. 46/44 Rodriguez-Ubis J. C. 5201621 Rodriguez-Ubis J. C. 1601204 Roduner E. 5191497 Rodwell V. W. 141126 40 41 42 Roeder E. 659129 36 58 Roelofs W. L. 3581202 Roemer J. 3841103 Roenneberg T. 463136 Roeske W. R. 4101423 Roessler P.G. 3571137 Roest J. M. V. 677191 Rogalska E. 6031103 Roganov G. N. 5171 375 Rogers C. B. 617154 Rogers H. J. 3311109 356188 Rogers M. 3011493 Rogers M. J. 3581234 Rogers R. D. 1601136 Rogers S. V. 55318 5561185 Roglans A. 6361112 Rogler J. C. 97164 Rogler J. G. 97/63 Roh E.-Y. 5901138 139 Rohl F. 331175 Rohm K. H. 2191109 Rohmer M. 142155 241151 602128 46 47. 48 Rohr J. 1101108 555154 55 59 Rohrer S. P. 109145 Rohwedder W. K. 911 Roininen H. 971114 Roitch U. 4521176 Roja G. 635128 Rojas D. R. 2571196 3001347 Rojas M. 981186 Rojatkar S. R. 677189 Rojo I. 6361125 Rojo J. A. 1831355 1861673 Rokach J. 1801123 125 1821293 Rokosz L. L. 141118 Roldan J. 981178 Rolinson G. N.33012 15 39 Rollins D. E. 4101396 Rollman O. 1441242 Roma G. 4751115 Romagnoli C. 474112 Romagnoli R. 650140 Roman L. N. 1601143 Roman L. U. 1601144 145 2561121 Roman M. 46216 Romanovskya V. N. 4071126 Romeo G. 65917 Romeo R. 65917 Romero A. A. 4091321 Romero J. 72149 3321149 Romero R. M. 372158 59 Romming H.-J. 356198 Rood S. 1441229 2421142 Rood S. B. 1441219 258 2421150 Roos P. H. 371131 Ropers H.-J. 241159 Ropson N. 5171335 Roque 0. L. 5151154 Rorig L. R. 5151212 Rosankiewicz J. R. 356188 Roschangar F. 5901132 Roschger P. 475197 Rose A. F. 296149 Rose I. A. 4521195 Rose J. E. 218130 31 Rose M. E. 6781186 Rose W. C. 2571184 Roseberry L. 971112 Rosell G. 1831350 Rosen M. I. 4101374 Rosenberg C.6511111 Rosenberg I. E. 109155 64 Rosenfeld I. S. 356141 42 Rosenmund P. 589166 Rosenstock G. 4081279 Rosenthal I. 1851526 Rosini G. 513118 Ross H. N. M. 3321168 372171 Ross J. H. 635175 78 Rossi G. C. 4081266 Rossi L. M. 4111447 Rossi P. 1811163 Rossi R. 159177 78 Rossignol M. 981156 Rossini C. 5151217 Rossiter J. T. 981181 182 Rossman P. 3311114 Roth G. P. 2571190 Roth H. D. 5211678 Rothchild J. 4511101 103 Rother A. 40194 635163 64 Rothofsky M. L. 4291129 Rothschild M. 96112 14 15 971118 Rotshteyn Y. 4081260 Roucouz A. 5161299 Roumestant M. L. 3321175 5191553 Roush W. R. 39/26 Roussakis C. 2991315 3011481 4641115 Roussel P. G. 3851205 Rouveix B. 4091365 Rowan M. G. 981179 602161 6031121 Rowan S.J. 5891110 Rowell-Rahier M. 96/11 659143 Rowlands M. G. 3851135 Rowlands R. T. 3321164 Rowley E. K. 109184 Roy A, 3861223 4091361 Roy K. 1821276 Roy R. 2561118 Roy S. 4091344 Roy S. C. 731156 157 180 Royer D. 588132 Royer J. 635150 Royo A. J. 5181427 Rubach K. 1861622 Rubenstein S. M. 1431199 2511168 Rubin D. 1811171 Rubin E. J. 1811171 Rubin L. J. 1841497 498 Rubio Gonzalez R. 3841116 Rubiralta M. 589172 86 Ruby C. L. 450121 5551106 Riicker G. 6781184 Rudd B. A. M. 372183. 85 Ruddock J. C. 5551112 Rudi A. 2571222 2991299 313 3001377 3011452 6791241 Rudic V. 463185 Rudino-Pinera E. 475151 Rudisill D. E. 3851139 Rudler H. 1861695 6031109 Rudnicki S. M. 1431148 Rudolf P.R. 519/550 Ruecker G. 1621309 405115 5 171328 5 181484 Ruecker R. 4071148 Rueffer M. 371133 Ruegger H. 5221803 Ruggeri M. 383124 Ruhland T. 384196 Rui H. 676130 Ruiz M. 1841459 4011199 Ruiz P. 71/21 1601194 Ruiz-Mesia L. 202113 17 Rumbero A. 676116 6781129 Rummakko P. 72159 Rumyantseva E. E. 4751108 Rundquist M. 142175 Rupp R. H. 1821276 Riisch J. 5561157 Rush C. P. 372185 Russ P. 44915 6 Russell G. B. 97196 Russell M. A. H. 4101407 Russell N. J. 356119 Russell R. M. 1441250 Russowsky D. 65914 Rustaiyan A. 255123 2561103 5 141103 5 191487 Rustan A. C. 1831419 420 422 Ruswinkle L. J. 330144 Rutiralta M. 30319 Rutjes F. P. J. T. 296173 74 463145 Rutledge P. S. 255144 2561112 Rutzler K.C. 2981195 Ruveda E. A, 81112 15 16 82156 Ruvinov S. B. 218126 Ryan C. W. 330117 Ryan K. 463136 Ryan K. A. 384109 Ryan R. O. 3571186 Rybalova T. V. 1591109 Rychlewska U. 1611205 1621323 Rycroft D. 602140 57 Rycroft D. S. 1621345 Rymerson R. R. 1851573 S Saa C. 4071159 Saad H. E. A. 4061116 4071149 474120 Saar J. 450168 Saaristo J. 1861659 Sabelis M. W. 97188 Sabol M. R. 40186 Saboureau A. 635154 Sabri N. N. 2561106 Sabri S. 82142 1611256 Sabry D. Y. 474115 Sacchettini J. C. 142167 Sacchi R. 1811728 730 733 Sacco M. 10183 Sachdev-Gupta K. 971112 116 Sada K. 3851158 Sada T. 427111 Sadanandan E. V. 2981213 Saddler G. S. 428191 Sadeghi-Jorabshi H. 1861694 Sadiq S. 2511212 Sadler I.602139 Sadownik A, 38511 70 Sadowski D. 4081276 Saeed M. T. 1841430 432 433 434 435 442 Saewe J. 4091301 Saez J. 731168 Saez V. 10816 Safaev M. A, 255141 Safonova E. Y. 1851561 Sagami H. 142173 74 1431136 137 138 139 15815 602182 Sagar K. S. 1621334 2581239 3001339 343 386 Sagara T. 4081242 246 Sagrero-Nieves L. 514197 98 Saha B. N. 5141139 Saha J. K. 5901140 Sahai M. 255152 Sahashi Y. 1881820 Sahm H. 142154 55 602128 45 46 48 Sahpaz S. 731168 Sahu N. P. 6771117 Sai H. 721120 Saidia B. 1841511 Saidkhodzhaev A. I. 1591100 1621294 Saigo K. 5171314 Saimoto H. 10185 86 9151 52 Saini R. K. 20120 Saino K. 6781188 Saint-Jalmes B. 741227 Saionz K. W. 618137 Sais G. 41 11455 Saito E.618142 Saito H. 9130 427123 4291123 Saito K. 40198 99 111 141 142160 61 71 15816 635183 Saito M. 159189 1861650 4291125 Saito N. 1861662 663 4071192 Saito T. 10190 1431213 241147 48 40711 70 Saito Y. 1881837 356167 4091307 Saitoh A. 4101432 Saitoh H. 67811 74 Saitoh K. 450155 555160 61 62 63 64 65 Saitoh T. 1431205 Saitoh Y. 1611261 Saka H. 2421107 Saka Y. 2971165 Sakabe T. 6171119 Sakagami H. 589185 Sakai H. 2981181 Sakai K. 159143 1821313 326 Sakai M. 4631105 Sakai R. 2971166 3011446 475 Sakai S. 5221773 58814 27 31 Sakai S-I. 5221762 Sakaki K. 1861654 655 Sakaki T. 3571131 Sakakibara I. 72170 Sakakibara J. 1811226 3851177 428189 Sakakibara K. 5171373 Sakakibara M. 9140 Sakakura A. 3001403 Sakamaki H.384154 Sakamoto M. 1611287 2561101 Sakamoto S. 463149 Sakamoto T. 2991287 4291128 Sakamoto Y. 428141 Sakarai A, 2421107 Sakata K. 1611274 4631101 5161263 266 Sakazaki R. 331155 Sakharova I. S. 218126 Sako Y. 463150 Saku N. P. 6781169 Sakuda S. 3581239 240 241 Sakui N. 5171355 360 Sakuma A, 1811151 Sakuma K. 2991331 Sakura S. 4091307 Sakurai A. 916 18 45 51 52 53 54 55 10185 86 87 89 90 93 94 981194 1431213 1441227 228 24 1/47 24211 10 I14 Sakurai M. 109138 Sakurai N. 10173 1611254 676133. 36 Salakhutdinov N. F. 5161305 5 171383 5 191574 521 I71 I 712 Salas J. A. 555149 84 85 86 Salas J. E. 555150 Salatelli E. 5891113 Salaun J. P. 1891902 Salazar J. A. 384179 Salazar-Aguilar N.E. 6771101 Saleh S. 1841482 Saleh Ajaz M. 82142 Salem N. 1801118 Salen G. 38455 Salidat M. C. R. 410/403 Salido S. 159159 3001411 Salih A. 6781192 Salin F. 1431135 Saliot A. 1871760 Saliou C. 39168 635157 Sall T. 1811197 Salomon C. E. 2971144 Salomon I. I. 4511121 Salowe S. P. 3321158 177 183 184 Salutin V. I. 5201608 Salvadori P. 5891126 Salvatella L. 5 181427 Sam K. M. 3841100 Samad S. A. 1841504 Samadizadeh M. 2561103 Saman D. 3851132 160 Samaniego W. N. 5171380 Samb A. 181/197 Samel N. 3571129 Saminathan S. 16011 98 1621331 Samizu K. 7311 79 589185 Sammes P. G. 82158 Sammons R. D. 4511119 Samuelson H. 4091288 Sancelme M. 4291106 Sancenon F. 5191487 Sanchez A. A. 255171 Sanchez F.J. 1841458 Sanchez H. 741271 Sanchez M. J. 2421105 1-82 Natural Product Reports 1997 Sanchez V. H. 731141 Satake M. 296166 69 71 3011429 Schenkel E. P. 1811191 6781177 Scholz S. 3851144 Sanchez Y. 1591115 463143 43 44 475194 229 232 Scholz T. 4071121 Sanchez P. 97/94 1611213 Satake T. 1851586 6111108 Scheper T. 1881839 Schomberg E. D. 4101383 Sanchez-Arreola E. 1601143 Satchwell P. 721113 Scherkenbeck J. 1101102 Schon R. 38511 72 Sanchez-Baeza F. 676113 Sathyamoorthy N. 356194 602187 Scherkenbeck U. 1101105 Schonewolf M. 555155 Sanchez-Ferrando F. 2581233 Sathyanarayana S. 588114 Scherrmann J. H. 4091286 Schoofs G. M. 660174 2971105 Sato A. 296137 463193 97 100 Scherrmann J. M. G. 4081270 Schoolev Y. N. 4091311 Sanchez-Tames R. 158133 Sato F.1821315 4111448 453 Schooley D. A. 1821264 Sanders C. 141138 Sato J. 4291128 Scheuer P. J. 159149 1841454 Schoonhoven L. M. 971108 Sanders J. K. M. 5891110 Sato K. 1611288 296122 49 2971160 161 2981173 Schopke T. 6781130 146 Sanders T. A. B. 180192 Sato M. 296173 74 3851192 NO 206 221 248 299~53 260 Schorr R. 3571147 55317 Sandham D. A. 651197 4101371 463145 5171359 5181414 3011451 490 428192 94 Schraudolf H. 2421168 24211 70 Sandler M. 4091303 Sato N. 2991301 Scheurbrandt G. 356153 2561144 145 Sandmann G. 141148 142180 Sato R. 3581233 Schewe T. 182/245 Schreglmann R. 3581213 602120 6031140 Sato S. 72/96 384175 463149 Schickli C. 218155 Schreiber G. J. 109132 Sandor P. 741245 Sato T. 1441249 296140 406171 Schieberle P. 1851550 Schreiber K. 38311 7 Sandouk P.4091286 41 11448 Sato Y. 1611268 2421160 I61 Schiegetz J. 71146 Schreiber S. L. 109167 2981188 Sandoval-Ramirez J. 384150 Satoh H. 142170 Schiehser G. A. 463195 5561130 Sandri J. 1821288 289 294 Satoh I. 3011438 449111 Schiff J. A. 463133 Schreier P. 158119 21 5 171326 Sands T. H. 331183 Satoh T. 677160 Schiff P. L. 405136 5211685. 688 705 San Feliciano A. 7117 21 22 23 Satoh Y. 2421166 6781133 Schildknecht H. 981150 151 Schreier P. H. 9811 71 36 12188 731151 188 202 203 Sattar E. Z. 255166 Schilling E. E. 1621314 Schrijvers R. 16011 78 1611244 16011 74 255143 47 Satterwhite D. M. 602160 Schiltz E. 5561156 Schripsema J. 371142 588140 Sangwan R. S. 142193 1431169 Sattigeri J. A. 1611290 Schinzer D. 1621347 Schroder F. 39164 5 1612 75 Sattler I. 1611236 4511157 Schlapbach A.5191548 Schroder K. 4511143 144 San Jose M. A. 4071199 Satyanarayana C. 159196 Schlatmann J. E. 372150 Schroeder D. R. 1101109,428193 San Martin A, 2581233 2971105 Satyanarayana Y. 3861235 240 Schlecker W. 427130 Schroeder J. D. 3841109 San-Martin-Clark O. 4091363 Sauerbrei B. 4511116 Schleyer M. 2571222 2991299 313 Schroepfer G. J. 3851188 Sano H. 4631105 Sauerwein M. 401129 3001377 3011452 650110 6791241 Schroepfer Jr. G. J. 3321194 Sano M. 2971167 Sauliner M. G. 109132 4291113 Schlosser M. 6361108 Schuber F. 1851556 565 566 Sano N. 41 11449 Sauriol F. 2571154 155 Schlottfeldt J. L. 4071132 1891900 3571181 Sano T. 20123 406169 4081225 Sauvain M. 61711 Schmalhofer W. A. 1591101 Schubert-Zsilavecz M. 474129 41 11458,459 Saux M. 255174 Schmaus G.159188 Schuch R. 1881856 3571162 167 Sansano J. M. 5171324 Savage T. J. 1421101 105 106 Schmeda-Hirschmann G. 406167 Schuchardt U. 1861678 Sanson G. D. 97166 514/63 5201656 Schmeider D. 97168 Schuermann W. 514160 Santacroce C. 2991278 Savarese J. 406145 47 Schmeiser H. H. 660177 Schuh K. H. 4101429 Santa-Maria. G. 1851609 Savona G. 255164 65 70 Schmeller T. 401129 Schuler G. 450135 Santana A. E. G. 475155 61712 Sawa R. 5561135 Schmelz E. A. 97174 Schiiller H.-J. 3571146 Santana J. M. H. 475196 Sawa T. 555167 5561135 Schmelzer K. 9811 71 Schulte E. 1851600 1861679 Santani D. D. 40189 203126 Sawa Y. 1431216 Schmid J. 372157 Schulte G. K. 29811 75 Santes C. M. 2561141 Sawada H. 1851529 Schmidbauer S. B. 5211735 Schult’s S. E. 4081227 Santisuk T.72166 Sawada M. 96/34 Schmidhammer H. 4081228 239 Schultz A. G. 4101402 618148 Santos L. 256182 Sawada S. 5901133 240 250 251 Schultz G. 142156 602149 51 Santos P. F. 428172 Sawant S. G. 4091316 Schmidt B. 650112 Schultz J. C. 97170 Santti R. S. S. 71140 Sawyer D. C. 4101401 Schmidt D. D. 4511147 148 Schultz L. W. 3001382 Sanyal G. 141118 Sawyer L. 3581245 Schmidt E. N. 1611235 255142 Schultz W. E. 1841490 Sanyal I. 3581243 246 Saxana G. 981165 Schmidt E. W. 2981211 4281105 Schultze W. 514154 Sanz J. 91/97 5 1511 79 Saxena V. K. 1621319 Schmidt F. 96138 219198 Schultze-Siebert D. 602149 Sanz L. C. 1851557 559 1881867 Saxton J. E. 58811 7 20 21 589146 Schmidt G. 428136 Schulunegger U. P. 96113 Sanz-Cervera J. F. 72179 428164 47 77 88 Schmidt G. R. 1841518 Schulz G.513122 5221814 5 171350 5 19/48 7 Sayer J. 331164 Schmidt H. 35711 73 Schulz H. 1801132 Sapi J. 42711. 428131 Sayo T. 142158 Schmidt H. L. 21719 Schulz S. 660147 Saporovskaya M. B. 218126 Sayrac T. 5181437 Schmidt J. 9113. 14 25 28 29 37 Schulz T. F. 39137 Saraf A. S. 4751107 Scappino L. A. 356165 38 50 101102 981173 1811217 Schulze K. 5201655 Sarangi A. 731125 Scarzella L. 4081204 1851572 2561138 38311 7 677197 Schumacher R. W. 296128 3011455 Sarda P. 109151 Schabdach H. 384140 Schmidt J. E. 4101384 427125 Sarg T.,659133. 37 Schacht M. 1421122 Schmidt J. M. 203129 Schumaker D. 463154 Sarikardasoglou S. 5141138 Schafer H. J. 4071186 Schmidt M. 4081284 Schumann G. 555155 Sarkar. B. R. 38511 76 Schaeffer C. 589182 84 Schmidt P. G. 650159 Schutte A. L.635181 Sarkar S. 1841500 Schaeffer J. M. 109145 48 Schmidt R. J. 3851189 Schwab J. M. 356152 Sarker S. D. 2012 8 1621293 Schaeffer P. 6791247 Schmidt R. M. 372182 Schwartz B. 2981229 475152 66 78 92 677155 Schaenzer W. 3841124 Schmidt R. R. 475159 Schwartz D. P. 1871719 Sarma N. S. 3001387 Schafer P. H. 218124 Schmidt T. 5191530 Schwartz R. E. 256177 Sarne Y. 4101425 Schafer P. M. 217117 Schmidt T. J. 162f321 255114 Schwartz S. 241192 Sarrette B.. 30316 Schaffner U. 96113 Schmidt U. 8111 82/61 428157 Schwartzman M. L. 1801136 Sarshar. S. 650133 676111 Schaffner W. 6781154 Schmidtsdorff W. 1881809 Schwarz G. 5 181469 Sartori G. 450188 Schaffrath U. 981195 Schmidz F. J. 650159 Schwarz J. B. 159195 Sasai H. 39119 5211663 Schaller H. 141134 Schmith V. D. 406145 Schwarz M.602154 Sasaki H. 6771112 Schamberger J. 5201582 Schmitt D. 6031138 Schwarz S. 384197 Sasaki K. 3861228 450178 Schaner A. M. 3581192 Schmitz F. J. 2981238 241 2991255 Schwarzenbach R. P. 463172 Sasaki M. 6361121 Schantl D. 474129 263 291 3001384 3011442 428190 Schwarz-Koske R. 21719 Sasaki T. 731174. 175 1841447 Schanus E. G. 1851527 Schmook F. P. 450184 Schwas D. E. 660174 2571159 2971158 2981181 202 Schapoval E. E. S. 5151152 Schneider B. 10199 100 101 102 Schwecke T. 450120 45 46 237 2991304 3011472 44917 8 9 Schardl C. L. 371137 Schneider C. 255132 650115 Schwede W. 38 511 44 650124 Scharrer B. 4091314 Schneider F. 1801147 Schweimer A, 1441222 2421108 Sasaki Y. 4281100 Schatzman R. C. 2981241 428190 Schneider G. 2421156 2561138 Schweizer E. 3571147 151 55317 Sasao S.618142 Schaumann E. 5 171332 Schneider J. A, 9110 5561156 157 Sasaya T. 731128 133 174 175 Schechter I. 241132 34 Schneider M. P. 1881846 Schweizer M. 3581212 213 5561157 741237 244 263 Schechter S. E. 241164 Schneider S. 1841513 5141103 Schwender J. 241151 Sashida Y. 6781191 Scheeren H. W. 109134 Schnell B. 475197 Schwenen L. 241168. 90 101 Sasho M. 46219 Scheffer J. J. C. 5141101 5151195 Schoenwitz R. 514160 Schwerdtfeger J. 401150 Saski T. 651170 5111370 60 118 9 Schoffelmeer A. N. N. 4091325 328 Schwieger R. 159156 Sassa T.. 9/21 27 1441235 236 Scheffold R. 291188 332 355 359 4101403 Schwinn A. 676140 2431186 187 2561136 137 Scheinkoenig J. 1821268 272 Schofield C. J. 218180 2191114 Schwope I. 159156 1621352 Sasse J. M. 9/61 64 67 Scheinkonig J.3571182 2431190 3321128 142 166 178 Scienza A. 5561196 Sastry C. V. M.. 731186 Scheinpfing H. 981195 179 181 188 189,196 Scilimati A. 1881840 Sastry G. S. R. 1871716 Schell J. 10198 3331209 211 212 223 224 228 Scofield A. M. 635122 36 Sastry M. 109142 Schemedes A. 1851520 372174 77 Scolnik P. A. 142182 83 Sata N. U. 2981248 Scheneider K. 1611269 Schollkopf U. 218134 Scora R. W. 5151204 Index of authors cited 1-83 Scott A. I. 1611236 241121 5171363 Scott J. A. 6791239 Scott J. L. 3851159 Scott K. N. 3011487 Scott L.,1601187 1621315 Scott R. H. 109146 Scott R. W. 411161 Scott W. J. 159164 2991256 5181459 Scotti C. 555183 Screglmann R. 3581212 Scriba G. K. E. 3851136 Scribe P. 1871760 Scroder H.6181157 Searle M. S. 108115 17 Searle P. A. 29811 72 247 3001388 Seaton N. 3571112 Seaton P. J. 589189 Seawright A. A. 660176 Sebastian A. 4101402 Sebedio J. L. 180197 1821295 296 1831354 1841492 493 1861613 636 Secker N. H. 4101381 Secor H. V. 21714 Sedgewick B. 356122 23 51 Sedlock D. M. 618155 Sedmera P. 4011151 4081253 428184 Sedrati L. 20113 Seebach D. 218137 51 52 53 54 55 56 57 83 Seeger R. 20212 Seeman J. I. 21714 Seemann M. 241151. 602128 Seepersaud M. 203142 Seeram N. P. 650154 Seff K. 401142 296155 Sefton A. M. 109185 Segall €I. J. 660164 Segura. R. G. 406198 Sehgal S. N. 450141 Sehlapelo B. M. 741245 Seiber G. 1101105 1101102 106 107 Seifert K. 255126 384140 5221781 783 801 6181181 6791236 Seigel P.M. 1851573 Seino K. 4091335 Seitz T. 6361123 Sejbal J. 3851171 Seki H. 741247 5221773 61118 17 Seki M. 121103 141247 Seki (nCe Imai) M. 611117 Seki T. 296169 2911115 5171373 Sekine T. 401111 635183 Sekiya A. 3851157 Seldes A. M. 3011478 3851181 676142 43 Selenghe D. 401101 Sellen M. 1821299 406154 Sellier N.M. 5191496 Sello G. 5201628 Selva E. 428191 Selvakumar N. N. 1591105 Selvapalam N. 618176 Semadeni P. A. 158129 5211703 Sembdner G. 1811217 1851555 Semenov A. A. 6181185 Sempere A. 4011199 Sen A. 40711 74 Sen S. 671l117 Senard J. M. 4081206 Senatore F. 5141136 Senba H. 6791248 Senda N. 291189 Sener B. 303122 6781182 Sener R. 659128 Sengupta P. K. 2991291 Senior I.J. 1811170 Senn G. 588130 Sensi P. 450184 Senter P. D. 109132 Seo Y. 2991312 325 3001379 383 Sepsi A. 4081238 Sepulchre C. 1821292 362 363 Sepulveda J. A. 1821251 Sepulveda-Boza S. 1611284 Seraphin D. 589164 Serban A, 3011442 Serebrennikova G. A, 180166 Serebryakov E. P. 5161304 Serghini K. 475183 Serhan C. N. 1801126 1841481 Serit M. 475173 Serpeel M. J. 4081275 Serra R. 513118 Serramedan B. 5211695 Serrano-Carreon L. 3571152 Serre L. 356139 Serric A. 4101389 Sers-Loehr J. 463125 Servat F. 1881812 Servel M.-O. 463178 Servettaz O. 255164 Sesin D. F. 3011437 Sestanj K. 650137 Seta K. 1861615 Setala H. 12158 Seth S. 1811714 727 Sethi V. K. 6791225 Sethuraman V. 5211678 Setlow B.3581234 Seto H. 2421149 2431198 2561136,143 42117 44917 8 9 45 111 08 168 55511 04 Seto S. 602184 85 95 6031104 Sevenet T. 20113 Skvenet T. 588112 37 617111 6 18127 677166 Severns R. M. 3011490 Severson R. F. 911121 1431201 Sewell T. J. 3331211 Sewon P. 1811157 Sexmero M. J. 159158 Seybold S. J. 96135 142194 Sezik E. 255125 5221789 Sgaramella R. P. 514197 Shaaban M. A. 659144 Shaari K. 731184 Shafer R. H. 109139 Shaffiee A. 450144 52 5551101 102 Shah A. H. 8114 82122 23 25 27 29 30 31 34 60 Shah D. H. 602133 Shah D. O. 1881849 Shah G. C. 5141102 Shah S. A. 218124 25 Shahan Y. 4091291 Shahi A. K. 5141140 Shaker K. H. 6191236 Shakhidoyatov K. M. 20149 Shakirov M. M. 2571194 200 201 Shakirov R.405113 22 31 32 406155 56 60 62 63 65 66 111 112 113 Shakirov R. 660162 Shalabi F. 1811162 177 1821247 1841450 Shalabi F. 2911157 Shalaby A. 47511 12 Shales D. M. 3311117 Shaltakov S. N. 1621298 325 Shamma M. 4061101 Sham’yanov T. D. 1621324 Shan Z. 4091319 450 Shang L. J. 255154 Shankaran K. 109188 Shanklin J. 3511172. 174 180 3581236 Shanmuganathan K. 5191555 Shanmugasundaram S. 659134 35 Shannon P. V. R. 589168 Shantha N. C. 1801103 113 1861681 Shao B. 6781150 Shao B. P. 415176 Shao C. 6781161 Shao L. P. 256184 Shao M. 514159 Shao R. 5171334 Shao Y. 5191558 6781137 138 139 140 141 142 143 144 145 Shapiro J. A. 971120 Shapiro L. H. 46213 Shapiro M. 5891112 Sharaf M. H. M. 405136 Share A.C. 401143 Sharkey T. D. 514157 60111 Sharma G. V. M. 1821323 329 Sharma K. D. 1831407 Sharma M. L. 159179 5141110 Sharma N. 3861233 234 Sharma N. D. 20125 Sharma N.K. 721121 144 141233 1851606 Sharma P. K. 3841117 Sharma R. P. 1601137 2571161 164 38317 Sharma S. C. 6791221 Sharp B. M. 4101419 Sharp H. J. 6511112 Sharp M. J. 40187 Sharpless B. K. 5161290 Sharpless K. B. 1821321 218188 5891121 Shashkov A. S. 6181156 167 168 183 Shastri P. N. 1881825 Shattuck-Eidens D. M. 1421112 Shaushekov Z. K. 1621307 Shavita Y. 4101414 Shaw A. K. 5201579 677199 Shaw B. A. 296177 Shaw B. L. 5211671 Shaw J. F. 1881850 Shaw J. J. 96144 Shaw L. 4091340 Shaw R.S. 741245 Shawe T. T. 39165 Shawl A.S. 5161241 Shcherbukhin V. V. 1591109 Shearer C. A. 4641108 Sheen W.-S. 141270 428145 474142 6 18152 Sheinkman A. K. 475172 Shekharam T. 1821308 Sheldon P. J. 555172 Sheldrake P. W. 4101441 Shelly J. 3001395 Shen B. 554136 37 38 40 41 42 Shen C.-C. 741212 Shen F. J. 6111120 Shen K. F. 4091330 4101382 Shen L. G. 677164 Shen M. Y. 6511102 Shen P. Q. 2561126 Shen T. Y. 650131 Shen W. 5201647 Shen X. 428161 616128 Shen Y . 406175 Shen Y.-C. 3011463 464 4641118 Shen Z. 1431173 2991289 Sheng C. 2421159 Sheng W. S. 4091322 Sheppard R. N. 311139 Sheridan J. B. 45211 77 188 Sherman D. H. 554129 30 31 Sherwin P. F. 241175 3851137 I38 Sheu J.-H. 296180 Sheu S. J. 47416 Shi D. 5151210 Shi J. G. 2571214 2511215 Shi L.W. 474110 Shi W. 142195 5111354 Shi X. 6361134 650118 Shi Y. 4071130 Shia G. A, 384168 Shibahara A. 1811151 152 1871761 762 769 Shibakami M. 3851157 Shibamoto A. 119136 Shibamoto T. 5141115 Shibano M. 650123 616134 35 6031103 Shibaoka H. 10172 2191120 Shibasaki M. 39119 1611216 268 5211663 Shibata D. 1801144 Shibata H. 1431216 159140 1601163 Shibata K. 255173 Shibata S. S. 1861617 Shibata T. 3001407 Shibutani H. 141253 Shibuya H. 5171311 Shibuya M. 731163 4511115 Shibuya T. 602195 Shida A. 101104 105 Shida N. 1591111 5201636 Shieh H.-L. 12195 Shields L. S. 450174 Shiels C. J. 39165 Shigematsu N. 296139 Shigemori H. 159146 47 2571158 159 296125 2981189 2991251 252 304 314 4631103 Shigihara T.2561136 Shih T. L. 109149 218168 Shih Y.-Z. 141212 Shikano M. 6361129 Shim J. H. 142197 108 1431151 152 5 161272 Shimada A. 20134 428160 Shimada H. 6781200 Shimada K. 3861222 44914 Shimada M. 11113 72155,731155 Shimada Y. 1811797 1881830 Shimamura H. 255136 6781151 Shimazaki T. 1821315 Shimazu A. 44917 5221755 756 Shimazwa R. 3571148 Shimiza K. 676135 Shimizu A. 2981214 428167 Shimizu H. 159175 Shimizu K. 5171329 Shimizu M. 218182 5211722 Shimizu S. 1821269 1881869 870 871 872 874 875 876 878 42117 Shimizu Y. 296159 60 3511115 463151 71 5561137 147 Shimoda H. 671151 Shimoda K. 5191492 Shimohigashi Y. 4081246 Shimoi Y. 5 171361 Shimomoto N. 421120 Shimomura K. 5171355 Shimomura O.463135 Shimoni M. 514164 Shimonishi Y. 296125 2981189 Shimosaki A. 618139 Shimoyama N. 1311 74 Shimura H. 2991316 Shimura M. 255176 Shin H. 1611255 1831427 Shin J. 2991312 325 3001379 383 Shin K. 4291112 5 13/14 Shinde S. L. 1611267 Shindo M . 5201598 Shindo T. 463193 Shing T. K. M. 159161 62 450123 Shingu K. 6181132 Shingu T. 255125 2571156 296140 41 42 303115 428163 463194 104 618157 58 676118 19 Shinkai K. 1811152 Shinkai S. 3851180 Shinmen Y. 1881869 870 871 872 875 Shinohara M. 1841485 Shinonaga H. 2991314 Shinozaki F. 3011441 Shinozaki M. 12157 Shinozuka T. 6361110 Shintani D. K. 3511161 Shin-ya K. 42717 5551104 Shiobara Y.,5211746 Shioiri T. 296134 3011441 5891114 Shiojima K.255113 6111118 6191214 245 246 6781174 Shiozawa H. 296126 Shiragami N. 635139 Shirahashi H. 1811226 Shirai K. 5181420 Shirai R. 428182 Shirakawa S. 109138 Shirasaka N. 1821269 1881878 Shirata A. 312154 Shirata K. 5211689 Shiro M. 1601179 1611242 2571220 221 3001373 374 331155 3851194 4751121 5201634 Shirota O. 428151 52 6191211 Shishibori T. 241141 Shishido K. 1621356 Shito T. 588115 Shivalkar S. A. 1611267 Shizuri Y. 296136 2981227 1-84 Natural Product Reports 1997 Shoemaker R. H. 2971153 Simmons C. J. 296155 Slattery M. 463162 Sokolov M. Y. I861614 Shoji J. 331155 6771103 6781133 Simoes F. 1621343 256193 Slavik J. 406164 4071167 Sole D. 589159 60 Shoji N. 2991314 Simolike G. C. 3011467 Slavik V.4071168 Solans X. 589172 Shone R. L. 475172 Simon A. 1441241 255174 Slavikova L. 406164 Soldaat L. L. 660157 Shoolery J. N. 650159 Simon B. 1601154 1811227 Slavin J. L. 71/37 39 Solel Z. 981196 Shoop W. L. 109149 52 Simon C.,4081229 236 254 255 Slavov V. 406151 Solem M. L. I811232 Shorshnev S. 474138 Simon E. 1821267 Sleeter R. T. 1861686 Soler E. 142157 602153 Shpatov A. V. 2571200 201 Simon H. 1421128 5211718 Sliniger P. J. 3321155 Solhuber M. 415184 Shu C-K. 5151218 5161254 Simon J. E. 1601133 134 Slocombe B. 33016 7 Solich P. 47419 Shu R. G. 617152 63 Simon J. W. 3571169 Slomp G.. 450178 Soliman F. M. 5171366 Shu Y. 514173 Simon K. 383/33 Slusarchyk W. A. 331153 Soliman H. S. M. 6781195 Shubina E. E. 1811223 Simon L. D. 20133 Smaldone D. 384144 Solladie G.5181455 635155 651181 Shukla V. K. S. 1801105 Simona S. 5201581 Small C. J. 556/200 Solladie-Cavallo A. 5 181412 423 1811215 1881834 836 Simoneau C. 1861699 Smart Y. C. 39152 Soloshonok V. A. 218179 Shukla Y. N. 82138 52 Simonet A. M. 971145 Smidovnik A. 1841496 Solovieva A. B. 384145 Shvets V. I. 4751104 Simoni R. O. 3561100 Smiley D. W. M. 1421113 114 Solovyeva T. F. 2011 7 Shyur H.-J. 2016 Simonin P. 142155 602146 Smiley K. L. 3321154 155 Somei M. 2981214 226 428167 96 Si J. Y. 677164 Simonsen S. H. 721111 Smit W. A, 1601159 4291110 Sia G.-L. 741267 Simpson M. J. 1831351 Smith A. J. 5181404 Somemiya K. 520161 7 Siahaan T. J. 82169 Simpson T. D. 1851564 Smith A. L. 5561126 635147 Someno T. 5561134 Siame B. A,. 981149 Simpson T. J. 1441260 35512 55313 Smith A.M. 218169 Somers D. A, 2561139 Sibbesen O. 372164 65 5561187 Smith B. A. 5181402 Somerville C. 35711 72 176 Sibbittt R. R.. 4521176 Sims J. J. 97199 981200 297199 Smith B. C. 463174 Somerville C. R. 1811148 Sibi M. P. 731138 154 Sin K. S. 474127 5221791 Smith B. M. 109168 Somerville S. C. 9811 74 Sica D. 2911123 2991284 285 31 7 Sinclair P. J. 218132 Smith C. C. 5201598 Somfai P. 40177 635144 45 384144 Sindelar R. D. 5171384 Smith C. J. 981203 Sommechai C. 91190 203145 Sicinski R. R. 3851142 3861221 Sindkhedkar M. D. 475156 Smith C. K. 109121 Sommer H. 5211705 Siddiqui A. H. 3861235 236 240 Sinensky M. 60117 Smith D. G. 24211 75 I76 Sommerfeld P. 401150 Siddiqui A. U. 3851188 3861235 Sing S. M. 3841114 Smith D. L. 671171 72 73 Somoza C. 5201.598 236 240 Singaram B.5191550 Smith E. H. 1851571 Somssich I. E. 981160 Siddiqui B. S. 203134 5221785 Singh A, 731125 475158 Smith G. D. 4101392 Son J.-K. 2191108 6771124 6781125 6791224 227 Singh A. K. 255152 2561113 Smith G. V. 5191536 Sonawane H. R. 5211666 Siddiqui I. R.. 6791231 383130 5151146 Smith H. 240114 Sondengam B. L. 6781126 Siddiqui M. A, 650157 Singh B. 82132 5161242 6781184 Smith I. C. P. 1871786 Sone H. 3001405 Siddiqui M. R. H. 1841504 Singh C. P. 1881849 Smith 111 A. B. 2981176 428182 Song D. K. 4081272 Siddiqui M. S. I831426 Singh G. 5171368 450114 Song J. 383131 Siddiqui S.. 203134 5221785 Singh H. 3841110 Smith J. A. 109165 Song J.-I. 3001379 383 6771124 6781125 6791224 227 Singh I. B. 3861234 Smith J. A. C. 96145 Song L. 142166 Siddiqui S.F. I831337 Singh J. 40189 1621345 203126 Smith J. D. 2981171 Song M. 2561146 Sidebottom P. J.. 5561174 6791231 Smith J. L. 330135 Song Q. 1431175 1621316 Sides. G. D. 109187 Singh J. M. 474116 Smith K. C. 2191103 Song R. 5191536 Siegel T. 1101102 107 Singh J. P. 82127 31 671161 Smith M. T. 4091358 4101392 Song W. C. 1811238 1851569 Siegner A. 5561156 Singh N. P. 3861230 Smith N. D. 6361102 Song Y.-H. 141134 Sielecki T. M. 4061106 107 Singh P. 401142 Smith R. A, 401109 Song Y.-N. 731183 Siemann H. J. 384197 Singh P. D. 331154 Smith R. M. 450179 80 Sonmez U. 256196 Siemiarczuk A. 384176 Singh R. S. 5141129 6791221 231 Smith S. 35514 5 3581206 211 Sonnenberg H. 475149 Siemsen L. 109130 Singh S. 3841127 128 214 215 217 223 224 225 Sonnet P. E. 1821306 1871719 792 Sienkiewicz K..3011436 635146 Singh S. B. 15817 602139 40 57 Smith T. E. 588134 794 796 1881813 828 829 831 Siergiejczyk. L. 3 861239 Singh S. M. 3841130 131 Smith. V. A. 2421104 115 117 832 833 851 Sierra J. 372167 Singh S. P. 20120 Smith V. M. 2421112 113 Sonobe H. 383118 Sieskind 0..3861215 Singh V. 1601151 676111 Smith W. B. 5191493 Sonoke. S. 1431216 Sigal M. V.. 109182 Singh V. K. 676112 Smrz M. 1851610 Sood R. P. 5161242 Siggaard-Anderson M. 35516 Singh V. P. 82123 28 6781184 Smyth M. M. 5141114 Sopchak A. M. 4101379 Sigurdsson S. Th. 188l810 Singhal P. C. 4091319 Snajberk K. 513138 Sophie H. N. 4101408 Sih C. J. 1871788 1881840 Singh-Sangwan N. 142193 1431169 Snapper M. L. 159165 2991254 Soranzo C. 109124 Sikora M. 5191537 5161275 Snatzke G.383120 21 588128 Sorensen H. 331/108 Sikorski. J. A,. 4511119 Singleton D. A, 5171306 Sneddon J. M. 1811182 Sorey S. D. 555155 Silfer J. A, 3011442 Sinnwell V. 39164 Sneeden A. T.. 450180 Sorgente M. G. 1.58118 Silks 111 L. A, 2191122 Sipahimalani A. J. 255159 Sneiders A, 463133 Soriano-Ferrufino J. 5151189 Silks L. A. 218146 2191119 Sipila J. 72159 Snider B. B. 463159 Soriano-Garcia M. 415151 Sills M. A.. 159t50 2981242 2991259 Siqueira J. B. G. 72181 Snider. J. V. 71/44 Soru E. 3331201 202 Silva D. H. S. 741265 Sirakov L. 408/285 Snieckus V. 6361112 650157 Sosa V. E. 1601190 Silva D. J. 109141 Sirakova I. 4081285 Snook M. E. 96121 Sothy N. 5141125 126 Silva G. L. 40711 78 Siro. M. 2571202 3001346 428143 Snustad D. C. 218173 Sotiropoulos J. 5191532 Silva M.82158 1611252 5201597 628 Snyder J. C. 96151 Silva M. G. V. 5161239 256 Sisti N. J. 5901130 131 Snyder J. K. 1601187 1621315 Soto F. 1611213 Silva M. V. 406198 Sitkowski J. 617182 Snyder L. B. 2561149 Soto J. 255111 Silvan A. M. 475184 Siverns M. 240115 Snyder W. C. 4511153 Soto. R. P. 3321128 Silvani A, 589181 91 Sivik M. R. 5191509 Sobey W. J. 3321188 Sotobayashi. H. 109/38 Silveira E. R.. 5151215 216 Sivonen K. 371117 6511122 Sobh M. 41 11451 Sotoma G. 428160 Silver G. M. 142153. 60114 Skagerlind P. 1881849 Sobolov M. 3321154 Soulet B. 5211695 Silver J. 6781198 Skala P. 1831410 1851573 Sobotik R. 4081241 253 Soulie J. 6511116 Silverman K. C. 15817 Skaltsounis A.-L. 20113 82136 Sobral M. E. 5151152 Souser M. L. 3331204 Silverman L. S. 3331216 61 711 I 74 Socci E.P. 383134 Southey E. A.. 372183 Sim C. J. 2971168 Skaro-Milic A. 41 11454 Soccolini. F. 5191551 Southgate R.. 33019. 331149 3321144 Sim G. A, 241121 Skiba P. J. 3581193 194 Soda K. 21715 219197 Southon I. W. 44913 Sim K. L. 635116 Skinner D. D. 450135 Sodano G. 2991322 3011422 Souto M. L. 5561152 Sim K.-M. 588139 Sklenar V. 4071168 3571134 3851209 Soutome T. 2991264 Sim K.-Y. 741267 268 Skoda-Foldes R. 384146 47 48 Sodeoka M. 39119 1611216 Sovova H. 5191518 Sim. W. S. 474137 Skolik J. 401132 133 136 635188 Soe T. 428134 35 Spande T. F. 20133. 34 40183 Simanek V. 4071151 4101442 Skorepa J. 1861670 Soejarto D. D. 731140. 255122 3011435 6361130 Simao S. M. 677162 Skorve J. 1831415 422 405135 475173 Spanevello R. A, 1841481 Sime J. T. 331170. 3321162 163 Skrede S.1831416 419 420 Soetens P. 618126 Spangel R.. 4091308 169 170 3331215 Skryabina Z. E. 5201608 Sofos J. N. 1841518 Spanu P. 63413 Simeon A, 3571146 Skrypczak E. 5211723 Soh K. 256198 101 Sparvoli F. 5561196 Simidu IT.,462120 Skrzypczak L. 521/723 Sohaibani M. 406154 Spassov G. 618135 Simmonds M. S. J. 97160 159159 Skulberg 0. M. 371117 6511122 Sohng J.-K. 1431148 Spassov S. 5221772 255151 3001411 Slabas A. R. 3571168 169 Sok D. E. 1851560 Spassov S. L. 5221769 Simmonds P.. 6791216 Slater J. L. 1801140 Sokoll M. D. 406196 Spatafora C. 1621341 25515. 297190 Index of authors cited 1-85 Spatz L. 3581234 Spear S. R. 330142 Spector A. A. 1801128 Spector D. M. 3571144 Spector R. G. 3311109 Speedie M. K. 450133 35 Speek A.J. 186/693 Speicher A. 1621339 Speight P. 677179 Speisky H. 4071188 Spence P. L. 4291118 Spencer A. K. 356137 56 Spencer G. F. 911 514167 5181456 Spencer J. B. 5561155 159 Spencer P. A. 2 18/90 2 18/91 2 19194 Spener F. 1851592 3571162 167 Spengel S. M. 6781154 Spengler B. 9/29 37 38 Spengler B. G. 9113 Spenser I. D. 218184 Sperry S. 6361127 Spessard G. O. 1611286 Spevak P. 3311115 Spickett C. M. 1431207 Spinella A. 2991322 3011421. 422 423 3851209 Spinelli J. 1861648 Spirikhin L. V. 5161304 Spiro R. G. 635123 Spiteller G. 1811224 1821267 268 270 271 272 273 274 1831389 390 391 392 1851538 539 572 Spiteller G. 81117 3571182 Spitzer V. 1811191 1871755 757 758 Spitzner D. 588128 Spivey A.C. 218180 Sponsel V. M. 1441256 2421126 132 133 134 146 2431196 Sporer F. 401129 Spratt B. G. 331161 Spraul M. 1621314 Spray C. A. 2191113 Spray C. R. 1441221 231 241160 91 2421127 128 129 130 131 152 153 154 156 161 2561139 142 Spreafico F. 553115 Sprecher H. 1801146 1841476 1871753 Sprengeler P. A. 428182 Sprikrishna A. 5181461 Spring O. 1601182 1621303 314 Springer J. P. 296149 Springer T. A. 10812 Spruijt M. M. 4091297 Spurgeon S. L. 602187 Sreenivas M. 4751110 Srere P. A, 6031111 Sridhar N. 3841110 Sridhar R. 1881816 Srikrishna A, 159191 1611290 Srimannarayana G. 475199 Srinivas D. 1821308 Srinivas K. V. N. S. 72168 80 2571153 3851206 Srinivas P. 51 11386 Sripada P. K. 1841487 Srirangam J.K. 2981191 Srivastava R. 677199 Srivastava R. P. 5111384 Srivastava S. D. 474134 415185 Srivastava S. K. 20218 474134 475185 Staby A. 1861652 Stadlbauer W. 475197 Stafford H. A. 6031113 Stahl B. 971136 Stahl M. 428195 Stahl R. 588129 Stahl U. 1891900 Stahl-Biskup E. 513122 Stain F. 4091286 Staley A. L. 4511105 153 St. Andre A. F. 588111 Stange R. R. 981200 Stangl A. 4081240 Stani G. 5161246 Stanislas E. 20114 Stankovic S. 383128 Stankovic S. M. 384190 Stanton K. J. 5191509 Stapleton J. A. 4101407 Stapley E. O. 330133 43 45 Stapley E. P. 330146 Stappenbeck F. 659115 Stark A. 1101102 107 Stark W. M. 33011 Starkmann B. A. 218162 Starratt A. 2017 Stashenko E. 5141115 Stasi S. 660149 Stassi D.555180 Stassinopoulos A. 109173 74 75 Stathopulos I. 3581213 Statkova-Abeghe S. M. 405117 Staudifer K. M. 4081266 Stauffer D. M. 3581249 Staunton J. 3571108 109 110 450120 45 46 48 51 55315 555168 69 70 74 91 113 119 120 121 123 124 125 Staver M. J. 450119 555171 76 80 Stavric B. 6511119 Stecca K. L. 3511177 Steele C. L. 1431210 Steele D. L. 33211 71 Stefanelli S. 159145 Stefani G. M. 256180 Stefano G. B. 4091314 Stefanov K. 1811167 1861626 Stefanovic M. 1621313 Steffan B. 2581238 618140 650112 6191244 Steffens G. L. 911 Steffens H. 4101383 Steffens J. J. 5 171340 Stegelmeier B. L. 39138 39 635125 660178 Steglich W. 159141 2581238 3011453 4291114 650111 12 6791244 Steidle J. L. M.96123 Steigel A. 1621321 Stein H. 1101105 Stein Z. 2511222 2991313 3001377 3011452 650110 6791241 Steinbeck C. 405115 Steinborn A. 5151209 Steinbrecher R. 514160 Steinbuchel A. 356168 69 70 Steinegger E. 401127 Steinke M. 463182 Stelmach J. E. 428176 Stempf I. 5211696. 700 Stengele M. 51 3122 Stenzel H. 981171 Stepanichenko N. N. 255140 Stephan E. 384191 Stephen R. 218118 Stephens P. J. 5191572 Stephens R. E. 1811182 Steppuhn J. 142181 Stermer B. A. 141136 Stermitz F. R. 96117 2561106 371119 5211715 5221782 650128 29 651176 659142 660172 73 Sternbach D. D. 5901137 Sterner B. A. 602127 Sterner O. 14311 76 1601166 1811219 227 1821254 256178 Stetter K. O. 1811207 Stevens-Miles S. 1591101 Stevenson P.67811 71 Stevenson P. C. 97160 105 Stevenson R. J. 2561112 Steward D. 911127 Stewart J. 4091291 Stewart J. C. 241123 71 2431195 Sticher O. 255124 2971119 4281104 5 171348 5211682,5221750 798 802 803 611l106 6791219 Stierle A, 1431200 1441254 Stierle D. 1431200 1441254 Still I. W. J. 3011450 428139 Stille J. K. 1821317 Stille J. R. 651190 Stimac A. 1841496 Stipanovic R. D. 1431163 1601122 123 Stirling I. 331187 88 89 94 StirlingFranqois I. 3311122 Stitzer M. L. 4101429 431 435 St Laurent D. R. 651195 96 Stobyarova L. G. 5171375 Stock D. 241133 Stocker R. H. 981171 Stockigt J. 371147 48 58814 Stocklin G. 1841463 Stoddart J. L. 241171 Stoehr T. 4091308 Stoessl A. 5561182 Stoev G. 401101 Stoewsand G.S. 1621312 Stoilov I. L. 1811193 Stojakowska A. 1601200 Stokes D. H. 33017 Stokie G. J. 3001355 Stoller A. 1821292 1831362 363 Stolow D. T. 3581208 Stolting J. I611262 Stoltz 0. M. 4291117 119 120 Stonard R. J. 81110 9 Stonik V. A, 2991323 2991324 3011448 Stoof J. C. 4101403 Stoops J. K. 356114 15 16 3 5711 45 358121 6 Stoppini A. M. 5161260 Storer N. P. 721114 Stork A 971108 Stork G. 1621330 Storusel’skaya A. N. 4071126 Stothers J. B. 5561182 Stout M. J. 91/79 Stout T. J. 2971151 2981221 46216 8 Stout V. F. 1861648 St-Pierre B. 371145 St. Pyrek J. 96151 Stransky K. 1861670 Strathmann W. 405111 Stratmann D. 5561157 Straub M. 3571146 Strauss A. 6781154 Strecker R. E. 4071202 Street I.P. 141150 602129 76 79 94 60311 02 Street S. D. A. 6361102 Streeter M. N. 3919 63516 Strelenko Y. A. 159167 1601159 Stremler K. E. 602172 Strid A. 1601166 Strittmatter P. 3581234 Strobel G. 1431200 1441254 2571230 Stroh J. G. 3011446 Strohl W. R. 555147 Stronach M.S. 10180 Strong C. R. 3581227 Stropova S. 4101423 Strtori E. 109193 Struchkov Y. T. 1621297 298 325 2 18/79 Strumpel M. 383125 Stubbe J. A. 109155 64 76 Stubblefield P. 4101418 Stuchlik J. 4081241 Stuitje A. R. 356139 3511169 Stumpf P. K. 3561100 3571153 Stiimpfel J. 65912 Stuppner H. 659130 Sturbois B. 1801147 Sturtevant J. M. 356136 Sturtz G. 5141105 5151176 Stylianides N. A, 1821312 Stymne S. 1891900 3511155 Su E. 4511116 Su J.1621351 3001384 428161 5111310 SU,J.-D. 72167 Su J. Y. 158126 Su J.-Y.,2561108 2971132 2991274 3001352 Su M. 4081212 5151181 Su M. J. 4061104 SU,T.-L. 20161 Su W. C. 1611209 Su X. 384167 Su Z. 6781172 Suami T. 4511146 Suarez E. 384179 80 3851191 406144 Suarez G. 55611 70 Suau R. 406198 Subbaraju G. V. 3001371 Subbarao R. 1821286 307 1831345 1841495 508 1861674 Subhadhirasakul S. 588131 Subramanian L. R. 5201580 52 11669 Subramanian P. S. 731149 Subroto M. A. 203148 49 Suchy V. 158120 Sudakov S. K. 4091345 Sudmeier J. L. 2191119 Sudo K. 12150 Sue C. 4081210 Suemune H. 1821313 326 Suenaga K. 3001403 Suenaga T. 450136 Suerbaev K. A. 5181400 Suffert J. 5181412 Suffness M.11130 Sufi B. A. 588124 26 Suga H. 5201618 Suga S. 5201618 Suga T. 142158 95 241141 5161273 5171354 362 377 5211690 602137 63 Sugahara T. 3011438 Sugama K. 5211741 6111112 6781193 6791240 Sugama K. 741214 218 Sugano M. 296137 4631100 Sugawara S. 741241 Sugaya K. 3861222 Sughihara A. 1871797 1881830 Sugimura C. 731161 Sugimura H. 2971125 Sugino E. 3011461 462 427111 18 Sugino Y. 450181 Suginome H. 131174 175 1601151 384175 5171325 Sugioka T. 2991264 5561154 Sugisawa H. 513153 Sugita M. 44917 8 9 Sugiura M. 30 11441 Sugiura Y. 109178 Sugiyama H. 1431136 137 Sugiyama M. 5221775 7311 70 Sugiyama S. 3001350 Suh D. Y. 1591108 Suh E. M. 463146 Suh H. W. 4081272 Suh N. 20115 Sukcharoen O. 3581239 Sukhina 1.A. 676132 Suksaurarn A. 97190 203145 255121 3851203 Sukumar E. 650150 6191226 Sulikowski G. A. 6361126 Sullins D. W. 3011446 Sullivan K. A. 4291108 Sultana N. 82142 Sultanov S. Z. 4081227 Sumaryono W. 2981229 Sumi Y. 159140 Sumida A. 1621291 Sumida Y. 5191567 Summerheim-Sjoberg K. 91158 Summers C. B. 97182 Summers R. G. 554138 39 44 Sumner Jr W. C. 450180 Sun B. 406190 Sun C.-M. 5561199 Sun D. 256197 Sun F. 202114 16 Sun H. 2571156,165 6771111 Sun H. D. 2561123 124 125 126 2571166 Sun H. H. 297198 618155 56 Sun L. P. 676128 Sun N. J. 1811182 Sun P. 6781161 Sun S. 3581251 252 1-86 Natural Product Reports 1997 Sun T.-P. 1431212 241145 46 Szabo F. L. 4071163 4081222 4511171 5181441 444 Takikawa H.2971147 Sun W. Z. 4081278 Szabo L. 589187 94 6111113 114 Takimoto A. 12157 Sun X. L. 4011147 Szabo Z. 4081229 Takahashi M. 131206 1851547 Takio K. 1431213 241147 Sun Y. 3001351 406173 Szabo-Pusztay K. 4011163 241 199 100 24211 61 296161 Takita T. 109178 Sun Z. 5151211 Szalontai G. 384146 4101427 463152 589195 Takizawa T. 611l113 114 Sunaga R. 5561128 Szantay C. C. 650135 46 Takahashi N. 912 8 15 22 28 32 Takushi A, 5221786 Sunagawa M. 109126 Szantay Jr. C. 650135 46 33 34 35 39 40 41 42 45 51 Talamo B. 356148 Sunazuka T. 109189 90 Szantay Cs. 589187 92 94 56 57 58 60 62 10185 86 91 Talbot S. J. 39137 Sundar Rao K. 1811154 SAntay Jr. Cs. 589192 92 1431213 1441227 228 242l149 Talbot T. L. 4101384 Sundram H. 39144 Szczepanska B.1621323 Takahashi S. 1101102 296126 Talinli N. 5111323 Sung M. S. 4151100 Szczepek W. J. 383119 312192 5181420 Tallarico J. A. 159165 2991254 Sung T. S. 141231 141239 Szekeres M. 10198 Takahashi T. 1841462 485 5201652 Tallents S. 4081281 Sung T. V. 617180 Szendi Z. 383110 Takahashi Y. 2971134 45 11167 Talo A, 2561139 Sunkara P. S. 39154 60 Szeto P. 63414 5181429 5561135 67616 Taloa M. 41 11460 Supriyono A. 2981229 Szewczyk J. 303123 Takahata H. 635149 51 Talon M. 241185 2421139 155 159 Suprynowicz Z. 414119 Szilagyi L. 39132 45 4081238 Takai Y. 296139 24311 98 Surcheva S. 4081285 Szocs G. 96138 Takaishi K. 5221756 Tamagnan G. 6511110 Suresh G.,611167 Sztaricskai F. 39132. 45 Takaishi Y. 255125 616148 611149 Tamai H. 1851530 Surico G. 5161271 Sztejnberg A.981196 Takamatsu S. 401111 Tamaki H. 1621312 Surico N. 4101413 Szulwesky K. 618160 Takano I. 1621302 Tamariz J. 5 181483 Suriol R. 589160 Takano S. 3011438 5181460 473 Tamayo N. 372187 4511150 555156 Surkova A. A. 159167 589195 Tamm C. 451197 Surleraux D. 5 171335 T Takao K. I. 1611208 Tamogami S. 981193 1601192 Susanna A, 12179 Takao M. 312151 Tampion J. 82175 Suter P. J. 24012 Takao T. 296125 2981189 Tampion M. D. 82175 Sutherland A. 2191115 Tabakovic I. 384187 589183 Takaoka D. 13l131 297189 2991275 Tamura H. 513153 Sutherland G. 4101407 Tabakovic K. 384187 589183 Takaoka S. 20154 159168 1601126 Tamura K. 1841453 5221789 Sutherland J. D. 218169 372175 78 Tabaszewska A. 3861239 255120 2571229 618169 75 650113 Tamura M. 3851157 Sutherland R. 33016 7 19 Tabata M.255125 311135 5221789 Takara F. 513113 Tamura N. 6111119 Sutlupinar N. 4101442 Tabata N. 159142 428180 5561188 Takasaki M. 5211676 Tamura 0.J. 218144 45 49 Sutter B. 142155 602146 47 48 Tabe M. 3851197 Takasawa T. 1431168 1601124 Tamura T. 312153 Suttisri R. 61613 Taber D. F. 40182 88 1611241 Takashi K. 5221755 Tamura Y. 46219 Sutton S. C. 3011471 3851210 214 182l290 1841482 297193 5161296. Takashima K. 12147 Tan A. K. 3321136 Suvachittanont W . 141I24 297 5181464 Takasugi M. 981180 372153 54 Tan B. 180194 4081258 Suvesh G.,91/95 Tabet J.-C. 3581247 383115 Takasuto S. 3851200 Tan C.-T. 141134 Suzuki A. N. A. 3581201 Tabet J-C. E. 5191496 5561190 Takata H. 5211662 Tan L. 6181176 Suzuki E. 384198 Taborska E. 4011151 167 169 Takatsuji H. 602141 Tan N.256195 97 617153 Suzuki H. 9/18. 53 56 10185 87 Tabuchi H. 5561183 184 Takatsuki A, 635139 Tan N.-H. 6181175 89 90 92 93 40193 111 1601203 Tabuchi M. 731187 Takauchi K. 1851530 Tan P. 39147 5221794 405120 4081225 5201616 61 7 620 Tabuteau F. 410l411 Takaya H. 5161298 Tan P. L. 4101417 622 555182 635161 62 6111118 Tacchini L. 1601169 Takaya J. 618169 Tan R. 2981194 6191214 215 245 246 Tachibana A. 142176 89 Takayama H. 384149 5221762 Tan R. X. 1611225 234 Suzuki J. 1611261 Tachibana K. 296124 62 43/37 58814 15 27 31 Tan Y. 406190 Suzuki K. 2511229 450155 463127 Tachibana M. 384141 Takayama K. 356194 Tana S. 5221762 415182 555160 61 63 64 65 Tacket L. P. 2981194 218 240 Takayama T. 463190 Tanabe T. 356126 Suzuki M. 142185 255113 2911133 Tada A. 91l113 635159 Takayanagi H.1591113 3001350 Tanahashi T. 4011161 162 5211743 134 589195 61615 6 Tada M. 25513 428180 5221755 756 808 Suzuki O. 1851548 1861654,1881873 Tada T. 514168 5111379 Takayanagi I. 4081242 Tanaka A. 1431183 158134 Suzuki S. 428183 5221776 Tada Y. 589167 Takazawa M. 1841515 Tanaka D. 5211733 Suzuki T. 109160 78 1861700 Tadano K. I. 1611208 Takebayashi T. 513153 Tanaka H. 731189 1621335 336 1881820 4091293 4101420 Tadauchi K. 618178 Takebayashi Y. 2981184 218165 255148 296139 450138 40 Suzuki Y. 9115. 56 981194 1441231 Tadera K. 91193 611176 85 86 88 Takeda K. 3001349 462121 5551100 241160 2421129 130 154 2561142 Tafani J. A. M. 4081256 Takeda S. 71119 40512 Tanaka J. 29111 70 5201598 Taga N. 462120 463127 Takeda T. 12191 Tanaka K. 2511156 5201614 616 Suzutani T.428141 Taga S. T. 450140 Takeda Y. 141253 158115 16 617 620 622 616137 Svendsen I. 35516 372l65 Taga T. 2571156 5551100 255125 256198 101 127 2511165 Tanaka M. 721104 105 106 107 Svensson L. 1821279 1871768 Tagahara K. 611192 93 95 166 5221786 789 108 109 741219 223 224 Svetashev V. I. 1811178 1811181 Tagliaferri F. 415174 Takei H. 1611270 1621328 2991279 33 11115 52 1I741 2991324 Taglialatela-Scafati O. 2971139 6361110 Tanaka N. 296126 312151 611160 Svistunova N. Y. 218179 2981228 246 Takematsu T. 9/58 62 Tanaka O. 731148 5221784 611156 Svoboda K. P. 514199 Taguchi H. 741214 Takemori A. E. 4081247 57 Swain M. G. 4101384 Taguchi M. 1861646 Takemori N. 4011192 Tanaka R. 2991301 6791248 Swaminathan S. 3851188 Taguchi N. 2981222 Takemoto T. 2971126 Tanaka S.3581239 241 371135 Swanson S. J. 450119 555171 76 97 Taguchi T. 3851194 Takemoto Y. 651169 Tanaka T. 11/44 141248 142176 Swarts H. J. 5181475 476 477 Tahara S. 981183 1611224 601110 Takemura Y. 201.53 54 55 56 1851535 537 255162 2561131 132 Sweatman T. W. 109128 Tahara T. 131207 415165 117 618169 70 72 75 81 3851197 513134 5221777 617196 Swedlund B. D. 1421112 Tahvanainen J. 911114 Takenaka Y. 2571218 3001376 Tanaka Y. 1871798 799 860 Sweeney J. B. 218180 Tai A. 5181432 Takeno K. 2421163 I66 255125 2981219 Sweeney M. 5211675 Tai H. 3511165 Takeoka M. 18ll761 Tanaki H. 1431177 Sweet F. 383110 Tai M.-H. 3581222 Takeoka S. 255155 Tanase T. 3851177 Sweet M. P. 1821317 Tai T. 616118. 19 Takeshima H. 3571149 4281100 Tandon M. 1431159 160 161 Sweetman B.J. 1841482 Taira S. 2991316 Takeshita A. 142159 61 Tane P. 256178 Swenson L. 356139 Tajima K. 5171378 Takeshita H. 1611272 273 2581232 Taneda K. 131127 Swenton J. S. 5181402 Tak H. 1621310 2511224 5 111394 Taneja S. C. 6791225 Swersey J. C. 3011465 Takabayashi K. 3581212 Takeshita-Koike A. 142160 Taneja V. K. 1851606 Swiatek L. 5211714 5221768 Takacs J. M. 4071164 Taketa A. T. C. 6191232 Tang J. 617116 Swiezewska E. 601/6 Takada M. 109131 Takeuchi J. 651169 Tang L. 553118 Swinny E. 141264 Takada Y. 555182 Swithenbank C. 635147 Takagi K. 256189 475150 Takeuchi S. 2971162 163 650122 Tang S. 5201598 Syamala M. 39/14 63519 Takagi T. 1801110 1851543 Takeuchi T. 296129 449110 Tang T. S. 1841505 506 450115 46217 555167 5561134 Tang X. 203131 514159 616146 1861637 638 639 641 1811805 Syamasundar K.V. 6191223 Takahashi A. 46217 135 5891111 Tang X.-Y. 203146 Tang Y-X. 5171362 5211690 Syed Rahmatullah M. S. K. Takahashi C. 296139 40 41 42 Takeuchi Y. 9/62 142185 1811800 803 188/834 836 428154. 63 43/94 104 107 Takeya K. 1621302 329 337 Tang Z. 5201627 1891906 618157 58 38511 77 4081221 224 232 428150. Tange K. 602137 38 Tani H. 131131 Sykes R. B. 330120 21 331153 54 Takahashi I. 109189 296138 428162 51 52 611187 619l211 33 31204 45111 71 Takeya K. 131208 209 12/74 75 Tani K. 428160 51315 Syoha E. 5211746 Takahashi J. 2561134 Takeyama K.-I. I441249 Tani T. 58818 Syono K. 9151 Takahashi J. A, 2561122 129 Takhi M. 72168 Tanida S. 450181 Szabo E. 4081240 Takahashi K. 1881837 838 406143 Takiguchi T. 255156 Tanielyan S.K. 5891115 Index of authors cited Taniguchi M. 142176 1601203 Tepfer D. 6511111 Tanii K. 1851535 537 Terada H. 2561127 Tanikawa H. 41 11449 Terada S. 5191567 Tanikawa T. 651191 Teraguchi M. 427120 Tanino H. 3011486 589190 Terahara T. 9117 Taniue K. 5211746 Teramoto S. 109179 Tanker M. 401105 Teranishi K. 384160 Tanker N. 635171 Teranishi R. 514162 Tann C.-H. 3331213 Terao H. 5221789 Tanner U. 40191 Terao J. 1861617 Tanoury G. J. 5201610 Terenius L. 4091349 353 Tao C. 5201598 Terpin A. 3011453 650111 Tao T. 5211710 727 Terras F. R. G. 981167 169 Tao-Wiedmann T.-W. 741246 Terrero D. 1611221 475196 Tapiero C. 513121 Terriaga I. 5171371 Tapiolas D. M. 46216 8 Terui Y. 331155 Tapondjou A. L. 6781126 Testa R.T. 109156 Tappel A. L. 1841510 Teste T. 2971102 Taqui Khan M. M. 1841504 Tetas M. 4101388 Tarakanova A. V. 5161294 Tezuka Y. 20140 741216 217 Taran M. 5161292 1591104 255153 676118 19 Tarchevsky I. A, 1851561 Thacker R. 96151 Tarkanyi G. 589192 Thakur R. S. 82138 1431169 Tarnchompoo B. 5181485 5 161275 Tarshis L. C. 142167 Thakur S. 1821246 Tasdemir D. 255124 Thanh L. T. 514184 Tashkhodzhaev B. 1621324 20147 Thapliyal P. C. 4751114 48 49 618162 Thapliyal R. P. 6181152 Tashklodzhaev R. 1621308 Thappa R. K. 618161 Tasker T. C. G. 331163 That T. T. 513121 Tassignon P. 1811225 I831338 Thayumanavan S. 401154 6361111 Tatarova L. E. 5161305 Thebtaranonth C. 1591118 5181485 5 191574 52 11711 Thebtaranonth Y. 1591118 5181485 Tato M. 676131 Thelin A.142175 60116 Tatsuki S. 5211731 Then R. 3311119 Tatsuoka T. 2981231 Theodoraksi E. A. 109168 296173 Tatsuta K. 555178 74 463145 Tava A. 5141140 Thepenier P. 58813 Tavares 0. S. 677165 Therissen K. 981168 Tavares R. 2981208 Thermos K. 4091364 Tawara J. N. 371119 651176 Theron E. 514165 Tay L.-L. 650154 67614 Theurillat R. 4101398 Taylor D. 331159 Theuring C. 371120 659141 Taylor D. K. 39113 Thevenon G. 1851605 Taylor D. L. 39154 55 56 57 59 Thibault D. 372191 61 Thickitt C. 180183 Taylor D. R. 97194 Thiel J. 401149 Taylor F. 1851584 Thiel M. 384196 102 Taylor H. R. 109144 Thiele H. 6781130 Taylor K. M. 4091360 Thier H. P. 1851600 Taylor L. T. 1801111 Thiericke R. 1101108 4511144 156 Taylor N. J. 555157 6361112 161 555194 95 5561136 177 I78 Taylor N.L. 5561172 I73 Thiiborg S. T. 6781192 Taylor P. B. 555173 Thin N. N. 5141132 Taylor P. C. 40180 Thirkettle J. 3331228 Taylor S. L. 9123 Thirugnanasambantham P. 650150 Taylor W. C. 72171 731145 741220 Thoern S. E. 4091301 221 82/45 Thom C. 5201639 Tazaki H. 741273 1431166 Thomas A. F. 5191495 1621346 1821257 255172 Thomas A. P. 5191549 Tchapla A. 1851605 Thomas D. 1881883 4091294 Tchoumbougnang F. 5151205 Thomas G. 401103 71143 5201637 Tebben P. 401150 450179 80 Tedesco R. 384188 94 Thomas M. L. 5161297 Tejero T. 6361125 Thomas P. 3321181 Tejima I. 9116 Thomas P. T. 4101406 Tekelova D. 513139 Thomas R. 554133 34 Telezhanetskaya M. V. 20150 Thomas S. A. 25711 74 406166 Thomas S. R. 650139 Tellez A. N.1601201 Thomas T. L. 356166 Ternesvari-Major E. 650135 46 Thomi S. 218136 Tempe J. 3331199 Thommen W. 1611275 Tempel A. 4091339 Thompson A. S. 3861227 Ternpelman R. J. 63517 Thompson C. M. 39111 40181 Templeton J. F. 38316 Thompson J. 3331207 Tena M. 981184 475183 Thompson J. E. 181lIY3 194 Tenaga Y. 4101371 3001409 Tencheva Z. 4091347 Thompson J. R. 256177 Tenconi B. 4091324 Thompson Jr. D. L. 63517 Tene M. 256178 Thompson K. 981147 Teng C. M. 4011165 177 189 Thompson P. A. 383124 428145 474124 42 61 8134 52 Thompson R. 602174 Teng C.-Y. P. 4521186 Thompson R. C. 5201599 Tengi J. 3311114 Thompson T. E. 1861698 ten Hoopen H. J. G. 372150 Thorarensen A. 1891910 Tenius B. S. M. 5181467 Thorat S. N. 4101406 Teo C. K. H. 1601135 Thorburn P.5201631 Teodorovic A. V. 5191545 Thoreau E. 3841104 Te Paske M. R. 981189 Thormann W. 4 101398 1-88 Natural Product Reports 1997 Thornburg K. L. 2561107 Thornburg K. R. 741266 Thornton S. R. 39171 3011436 635146 Thornton-Pett M. 5211671 Thorpe P. C. 981147 Thorsen J. 5221749 799 Thorson J. S. 4511124 125 Thorsteinsson F. 1881810 Threlfall D. R. 601112 602115 25 6031125 134 135 137 Thumm M. 3571146 Thurman P. F. 356188 Tian J. 5 141111 6171111 Tian R. 6781188 Tian R. H. 203140 Tianasoa-Ramomojy M. 1621315 Tianhu L. 109161 Tianosoa-Ramomonjy M. 1601187 Tibirica E. V. 71143 Tie D. Y. 5151190 Tiebes J. 296173 74 463145 Tiekink E. R. T. 5211674 Tietze L. F. 1601128 5171317 5221814 Tillequin F. 20113 82136 474126 617111 618174 Tiller S.A. 981202 Tillman J. A. 96135 142194 Tilquin B. 513124 Tirnmerman B. N. 255119 Timmons D. W. 741266 2561107 Tinant B. 660156 Ting A. Y. 5891118 Tinkl M. 6361112 Tinto W. F. 159173 2971148 3001333 361 381 67618 617169 Tion G. H. K. 4091359 Tirillini B. 474111 5161260 Tischler M. 109149 6791206 Tisnes P. 4081256 Tisser R. 51319 Tits M. 58812 589155 Tius M. A. 5221813 Tjon G. H. K. 4091325 328 332 355 Toaima S. M. 676131 Toba M. 1841505 506 Tobe T. 651191 103 Tobe Y. 2971103 Tobin M. B. 372178 Tobinaga H. 72196 Tobinaga S. 72174 75 Tochtermann W. 1601172 Toda J. 20123 406169 4081225 41 11458 Todaro L. 3311114 Todd J. S. 296143 48 Todoroki Y. 158136 37 Todorova M.372168 Toepfer A. 10815 Toffel-Nadolny P. 47411 7 Toghiani H. 5191515 Togni A. 5181443 Tognoni A. 555183 Toh H. 356126 Tohma M. 3851156 192 Tohno M. 3331214 Toia R. F. 5561199 Toida T. 1611287 Toiron C. 676116 Tojo E. 255111 Tokar C. J. 5181442 Toki T. 428158 Tokimatsu J. 731198 Tokioka K. 721118 Tokiwa Y. 5561128 Tokoroyarna T. 72163 64 741251 255173 Tokuda H. 618181 Tokuda M. 5171325 Tokumaru S. 1841516 Tokunaga M. 5161298 Tokunaga Y. 1621353 3001341 428183 Tokuyama S. 4101427 Tokuyama T. 20134 Tolkachev 0.N. 4071155 Tollari S. 20119 618130 Tollsten L. 971126 133 138 Tolman R. L. 3861225 Tolman W. B. 5181442 Tolstikov G. A. 4081227 5161304 Tolvanen A. 589195 100 101 Toma L.475198 Tomas A. 3851143 Tomas M. C. 1851609 Tomaschko K. H. 97189 Tomassini L. 521171 7 5221752 Tome F. 4061114 4011166 Tomei P. E. 5161233 Tomer K. B. 1801117 Tomi F. 5171371 Tomikawa Y. 5 171320 Tomimori T. 6781151 Tominaga R. 10173 Torninaga Y. 1871797 1881830 Tomioka H. 554122 Tomita F. 4511171 Tomita S. 1441244 659111 Tomoda H. 159142 3571149. 428180 5561188 Tomszek T. 1841446 Tonali P. 4081208 Tonche E. M. G. 741271 Tonelli C. 5561196 Tong C. 40519 6361128 Tong X. J. 2571160 Toome V. 331181 Toong Y. C. 1821264 Tooptakong U. 255121 Top S. 3841104 Topcu G. 1621304 255168 256195 96 97 Topfer R. 3571170 Topiwala U. P. 741226 Toppo G. 428191 Torchinsky Yu. M. 218126 Toregozhina Z.R. I621307 Tori M. 159168 99 1601126 1621291 335 345 255120 55 2571229 6 5 0113 67 71122 67 9/20 7 Torigoe K. 463143 Torikata A. 296126 Toriya Y. 1441249 Tornus I. 450170 Torok D. S. 1601139 Torregiani E. 82120 2561151 2571152. 163 I70 Torrekens S. 981168 169 Torrenegra R. D. 1601201 Torres F. 981178 186 188 Torres J. M. 2561121 Torres R. 5 171353 554129 6791243 Torssell K. B. G. 20122 72199 Torti F. 554145 Torto B. 97198 677178 Toscane R. A, 2561104 Toscano R. A, 255163 Toshima H. 296158 Tosi B. 474112 Toske S. G. 296127 3011445 Toste F. D. 3011450 Tosun A. 401105 Tosun F. 401105 635170 71 659140 Totani Y.. 1851528 Toth G. 4081236 254 255 Toth M. 96138 Totoribe K. 3011428 Touchstone J.C. 179123 Tournois H. 1811225 Towers G. H. N. 91/94 981165 Townsend C. A. 3321148 150 152 153 158 171 172 177 183 184 185 186 3331203 208 210 216 218 221 222 225 227 229 372169 72 73 5561164 168 Toya T. 513117 Toyama S. 101104 I05 Toyoda T. 5151156 Toyoda Y. 3851193 Toyokuni T. 4511152 Toyooka N. 6361131 651186 Toyosaki K. 6791238 Toyota H. 109189 90 Toyota M. 1621335 348 1811230 5221810 618141 Trail S. 241192 Trainotti A, 1611229 Trakatellis A. G. 1851519 Tran Huu Pau E. 65015 Tran N. H. 15814 2991270 Tranchepain I. 1821318 Trang N. T. D. 5171351 Trani M. 1891908 61713 Trapp S. G. 3021495 3851169 Traquair J. A. 1811202 Trau M. A. 4081206 Traven V. 474138 Travert S. 20114 Trawager A, 96/19 Traynor J.R. 4081239 240 Trebert Y. 1851550 Tregubova I. N. 5181448 Trehan 1. R. 3861230 Treichler H. 451195 Treitner A, 474127 Trejo W. H. 331153 Tremblay M. R. 384171 99 Trendafilova A. B. 1601196 161I285 Trendel J.-M. 6791247 Trevien V. 406153 Triana J. 1601180 Triantaphylides C. 1881885 Trigo J. R.. 3911 659145 46 660153 54 Trincone A, 1811207 Tringali C. 1621341 25515 2571203 296181 297190 96 97 Trinh D. C. 5141127 Tripathi Y. C. 82128 31 Trischman J. A. 46218 Trivedi G. K. 72160 Trivedi R. K. 1841499 Trivellone E. 255115 2971154 3001408 412 413 Troconiz I. F. 406144 Trofimova N. N. 6781185 Trogolo. C. 5211742 Tropsha A. 71129 30 Trost B. M. 513111 650149 Trova M.P.. 475163 Trowitzsch W.. 4521187 5561149 Trowizsch-Kienast W. 61 7120 Trudykov K. M. 1621325 Trujillo J. M. 72149 123. 731160 Trumble J. T. 971120 Trundell M. L. 650145 Truneh A, 2981207 Truscheit E. 4511147 Truumees I.. 4291129 Tsai H.-F. 371137 Tsai I. L. 4071182 4081214 474124 42 Tsai I.-L. 20115 741270 428145 61 718 6 18134 6 18152 Tsai I. S. 405116 Tsai I.-W. 617119 Tsai J. 4101422 Tsai M.-D.. 4521194 Tsai W-J. 5201642 Tsamo E. 72169. 67617 Tsankova E. T. 1601196 1611285 514184 135 5151161 Tsanuo M. K. 97198 Tsao S. W. 450122 4511106 5561133 Tsay J.-T. 356145 Tsay S.-C. 109160 Tschesche R. 8112 3 82153 55 57 59 72 73 74 1601156 Tseng L. F.. 4081272 Tseng Y .-Y . 82133 Tseng. Y. Z..4071189 Tsevegsuren. N.. 1811155 Tsopelas C.. 65016 60 Tsubuki M. 39127 Tsuchiya T. 109129 Tsuchiya Y. 3331214 Tsuda M. 2971149 2981236 237 2991304 4091293. 428174 Tsuda T. 1861637 Tsuda Y. 4111458 459 Tsugi M. 4101420 Tsugoshi T. 46219 Tsui H.-C.. 635134 Tsuji J. 9811 74 Index of authors cited Tsuji K. 3011428 Tsuji M. 159143 Tsuji T. 4631103 Tsujibo H. 72148 Tsujii E. 635139 Tsujita M. 1441244 Tsujita T. 20134 Tsujiyama T. I621329 Tsukamoto S. 2971162 2981244 Tsukamoto Y. 3581219 Tsukamura M. 356190 Tsukanov I. A. 5181400 Tsukazaki N. 6361112 Tsukitani Y. 463137 Tsumuki H. 981146 Tsuno T. 555162 64 Tsunoda K. 1861655 Tsunoda T. 384159 5211731 732 Tsutsui C. 475182 Tsutsumi N. 3861222 Tsuyuki T.450165 Tsuzuki K. 109189 90 555189 Tsuzuki S. 1861700 Tsuzuki W. 1861700 Tsvetkov 0.Ya. 6781183 Tu C. C. 218129 Tu P. 5211748 Tu Y. 1611248 Tu Y. Q. 5181452 Tu Z. 617116 Tuba Z. 384146 47 48 Tubaki K. 20140 1591104 Tucker A. O. 5141105. 109 5151155. 176 180 223 Tucker D. J. 1841445 Tuladhar S. M. 3021494 3851198 Tulenov B. I. 401147 Tuleupov B. I. 636195 Tulyaganov T. S. 20143 44 Tumen G.,5141138 5151171 193 198 199 200 201 224 227 231 232 249 253 Tumlinson J. H. 97185 86 Tunac J. 330145 Tunsuwan K. 971100 Tuomisto L. 408/277 Turchan J. 4091352 Turcotte J. G. 1801104 107 1851590 603 604 Turdibekov K. M. 1621297 298 307 Turgeon R. 96150 Turgunov K. K. 20147 48 49 618162 Turk R.96119 Turkistani A, 406154 Turkiya M. A. 218123 Turlings T. C. J. 97185 Turmukhambetov A. Z. 1621297 297 Turnbull C. G. N. 241168. 101 102 Turnbull K. W. 6031120 Turner D. L. 356124 Turner J. M. 4511165 Turner M. A. 3581245 Turner M. L. 4101384 Turner N. J. 372184 85 385/205 Turnowsky F. 356155 Tutko D. 158138 Twitchen B. 2421168 Tyagi A. 255158 Tyagi 0. D. 721121 731125 144 741232 233 234 Tykhananov R. Y. 4091351 Tyler J. W. 331171 3321173 3331197 200 Tyler P. C. 39146 635135 Tyman J. H. P. 180157 Tyms A. S. 39154 55 56 57 58 59 61 Tyystjarvi E. 1811157 Tzakou O. 514181 Tzschentke T. M. 4081284 U Uang B-J. 5201642 Uberbacher E. C. 3581216 Ubik K. 158120 3851132 Ubukata M.428162 Ucciani E. 180190 Uchida A. 463150 Uchida H. 4071184 Uchida K. 218165 372192 406143 Uchida M. 142159 Uchida N. 1621291 Uchida Y. 4091335 Uchino H. 109138 Uchio Y. 1821256 3001365 Uchiumi T. 144121 7 Uchiyama M. 9111 26 27 48 49 Uchyama T. 218189 Ucknes S. 2421122 Uda H. 2991264 5561154 Udagawa H. 741240 Udovichenko V. I. 4101438 Udvarnoki G. 555155 59 Ueda S. 2561120 124 5161265 5211724 5221757 602155 56 69 Ueda T. 38511 77 5221766 677151 Ueda Y. 5211746 Uehara T. 1601149 256183 Uematsu N. 428140 Uemura D. 296132 3011426 463126 588125 6361128 129 Uemura M. 401155 741222 Uemura N. 450165 Uemura T. 1621340 Ueng C. H. 159144 Uenishi J. 5161295 Ueno A, 731172 6781131 163 166 173 174 Ueno H.2561148 Ueno M. 5561134 Ueno R. 218128 75 Ueno T. 6781153 178 179 Uenoyama K. 15811I Ughhetto G. 108110 Ugi I. 3861241 5181419 Uguen D. 5211701 Uhlig G. 463154 Uhlig H. 5201655 Uhlig J. W. 203147 Ukita T. 721101 103 115 Uknes S. 981204 1441226 Ulberth F. 1861623 Ulibarri G. 159163 Ullah A. H. J. 5561167 Ullman M. D. 1801106 Ullrich V. 3581237 Ullubelen A. 677153 Ulrich T. 141130 Ulshafer P. R. 588111 Ulubelen A. 72182 83 1621315 20219 13 255168 256195 96 97 Umarova R. U. 255128 Umasundari P. 731186 Umbacher G. 96119 Umehara K. 6781131 173 Umemura. M. 5171320 321 Umeyama A. 2991314 Umezawa B. 450165 Umezawa H. 109178 4511166 172 46219 Umezawa I. 449111 12 450113 Umezawa K. 5551118 Umezawa T.71113 72155,731155 Umurzakova R. Z. 4071126 Undeutsch B. 384197 Unelins C. R. 971128 135 5151207 5211736 Unger F. M. 450171 Ungerstedt U. 4091353 Ungur N. I). 514177 Unkefer C. J. 218/46 47 48 76. 219196 101 119 122 Uno H. 5201620 622 Uno M. 5181420 Untersteller E. 296173 74 463145 Unver N. 61717 Unwin N. 514176 Upadhaya S. P. 5141130 Upadhyay R. K. 5171368 Upper C. D. 240112 Upshon P. A. 331158 121 Uramoto M. 1601203 256111 7 52 1I689 Urbach J. 1441245 246 Urban E. 158132 1601131 Urban J. 38511 71 Urban S. 1611232 25519 2981215 216 269 282 Urchegui R. 5201644 Urgert R. 2561116 Urones J. G. 159158 60 102 25511 6 50 51 Urs M. K. 1811161 Urushihara M. 218165 Urzua A. 731142 1611284 255111 12 4061101 Usami M.296166 463144 Usami Y. 296141 618157 Uskokovic M. R. 1831368 Usmani S. B. 203134 Usui S. 3001365 Uszycka-Horawa T. 383123 27 Utsumi H. 296171 Utz W. 731141 741271 272 Uyanik C. 384151 Uyeo S. 303118 Uzan R. 635133 Uzawa J. 2561136 Uzio R. 5161288 V Vaciago A. 450175 Vaeaenaenen T. 3851133 Vagelos P. R. 3331206 356117 18 27 30 31 40 41 42 48 49 50 101 Vago I. 589187 Vahemets A. 3571129 Vahlensieck U. 40711 75 Vaillancourt V. 5201602 Vainiotalo P. 5191566 Vaishnov M. M. 6771104 Vaissermann J. 3841104 Vajna de Pava O. 1601167 Valcic S. 2581231 Valdeira M. L. 256193 Valencia E. 588111 61 7121 Valentekovich R. J. 2981188 Valentin H. E. 356168 Valentine B.P. 3331198 Valentini G. 5141104 5151194 Valera A, 721123 Valerga P. 1611257 Valka I. 4071151 Valle M. 1851557 Vallejo M. C. G. 97197 Vallejo M. I. G. 97197 Vallgaarda J. 5201646 Vallipuram K. 42716 Valls N. 589199 Valls R. 25516 8 297194 101 Valpuesta M. 406198 Valterova I.. 971135 137 513136 Van Aken H. 406148 Vanaman T. C. 356127 van Beek T. A. 971108 van Beeuman J. 330129 Van Burke N. T. 109127 Van Calsteren M. R. 109195. 16 11207 Vandais A, 2571193 van Dam N. M. 96155 371120 659141 van de Bovenkamp P. 2561116 Vandekerkhove O. 1811186 van den Berg E. M. M. 2191121 van den Berg J. H. 1441218 Vandenbergue D. R. 1601132 van den Brenck A. L. 3011443 Van den Eeckhout E. G. 1601132 Vanderah D.J. 2991291 3001397 3 99 van der Baan J. L. 2981186 5211665 van der Boom J. A,. 109119 Vanderhaeghe H. 21 718 van der Heide T. A. J. 5211665 van der Heijen R. 141123 371140 43 602123 64 89. 6031134 van der Helm D. 2991255 291 3001395 442 428190 463125 91 van der Heyden K. A. 1601177 Vassileva E. 428131 van der Hoeven R. A. M. 60119 Vassilopoulos V. N. 1851519 Van Der Laan J. W. 4091309 Vatela J. M. 1821295 296 Vanderleyden J. 981169 1831354 1841492 493 van der Maesen C. 218177 Vatele J. M. 5181413 van der Marel G. A. 109119 Vathy I. 4091302 Vandermeersch E. 406148 Vaughn S. F. 981163 514167 van der Meijdin E. 96/55 Vizzquez A. 1611211 van der Plas L. H. W. 5111370 Vazquez M. J. 3011439 Vanderschuren L. J. M.J. 4091297 Vazquez P. 1601204 325 332 Vazquez P. 6781129 Vanderveer D. G. 677178 Vazquez-Flota F. 371149 van der Velde D. G. 2571175 176 Vaccaro W. D. 82162 69 179 Vdovin A. D. 618132 Vanderwal D. 96/35’ 142194 Veale C. A, 1801124 van der Walle G. A. M. 218120 Vedana T. R. 46215 2 1911 II Vederas J. C. 3851161 4511129 130 van der Walt J. J. A. 5151203 5561160 van der Weg G. 2561116 Veen G. 635178 van der Wielen C. M. 2191116 Veih H. J. 11Ol102 van der Wildt J. 71/18 Veilleux R. 3841130 131 Van Duyne G. D. 3011437 Veit M. 401126 635169 Vanegas H. 4091331 Veit R. R. 96/41 van Engeland H. 4101408 412 Veitch J. A. 5561129 Van Engen D. 296172 Veith H. J. 650119 Van Epp J. E. 450173 Veith M. 1421128 2581231 van Esch J. H. 5161293 Velasco-Negueruela A.5151157 Van Etten R. L. 2191109 175 179 5 161226 Vangedal S. 3311108 Veleiro A. S. 3851150 Vanhaelen M. 406157 58 Velichkova A. 4091347 Vanhaelen-Fastre R. 406157 58 Velluz A. 1611275 van Haren E. R. 218178 Velten R. 159141 van Heijenoort J. 110l102 103 104 Veltkam D. J. 67611 105 106 107 Venanzi L. M. 5 181443 van Heijenoort Y. 1101102 103 Veng-Pedersen P. 4101375 104 105 106 107 Venkateswarlu R. 731137 van Hoof N. 5191498 Venkateswarlu S. 5181461 Vanhove A, 218142 43 Venkateswarlu V. 20218 9 Van Hove F. 3321127 Venkateswarlu Y. 2571228 van Hulst R. 4511151 297195 2981245 2991310 van Leuren F. 981168 169 Venkatraman G. 741268 van Loon J. J. A. 971108 Venkov A. P. 40511 7 4071156 Van Loveren H. 4091309 Venturelli F. 51 3/18 659112 Van Montagu M.1601132 Venugopal M. J. R. V. 1621334 van Nienkerken E. J. 96/38 2581239 3001339 van Oeveren A. 71 135 7211 I7 Vera R. R. 5151151 Van Ree J. M. 4091297 Verbiscar A. J. 241155 2421177 van Rensen I. 401126 Verbist J. F. 2991315 4641115 VanRollins M. 189/901 Verbree E. C. 356139 van Soest R. 2981229 Vercauteren J. 5221763 Van Soest R. W. M. 2981208 Verdaguer X. 5201632 van Tamelen E. E. 588125 Verde J. 741271 van Tilborg K. A. 4101386 Verde S. J. 731141 Van7 L C. W. 4511173 Verdegem P. J. E. 219l111 118 Vantrappen G. 109192 Verdoorn G. H. 635180 81 van Uden W. 7115 35 Vereshchagin A. D. 1861672 van Veldhuizen A. 971108 Vereshchagin A. G. 1851577 578 Van Vranken D. L. 4291115 116 Veretenov A. L. 1601159 Vanwetswinkel S.3321127 Verfurth C. 3571142 van Wijk C. A. M. 96/54 Verfuerth U. 5211670 van Winkle W. B. 1861697 Vergani L. 4091324 van Wyk B.-E. 635173 80 81 Vergauwe A. N. 1601132 Vanzanella F. 463199 Verheyden P. 38311I Vaquette J. 2015 474126 Verlarde K. 218176 Varaprasad C. V. N. S. 1821311 Verma A. K. 3861232 233 450180 Varavudhi P. 4091362 Vermeulen D. 1851588 Varea A. 731153 Vermeulen R. J. 4101403 Varese M. 2571163 185 Vernooij B. 981204 Varga E. V. 4101423 Verotta L. 82120 676131 Vargas C. 2561135 Verpoorte R. 371140 41 42 43 Vargas D. 256188 588140 60118 9 602114 Vargha E. 217116 23 64 89 6031134 Varghese B. 475158 Verpoorte R. 96/55 141123 Varim F. 4081259 Verrall M. S. 330140 Varin F. 406146 Verrier H. M. 650139 47 Varjas L. 1611250 Versace R.5891112 Varnerot A. 356187 Verstegen-Haaksma A. A. 5181475 Varoglu M. 2911159 4631102 476 477 Varvas K. 3571129 Vertommen J. D. 406148 Vasanth S. 1601188 6781127 Vervoort H. C. 3001375 Vasconcellos M. L. A. A. 72l110 Verwoert I. G. S. 356139 Vashchenko V. V. 5181436 Vesper T. 5221781 801 Vasilenko I. A. 218121 Vessieres A. 3841104 Vasishtha A. K. 1841499 Vetter W. 1861683 1811772 Vasquez A. 16011 48 Veuth M. 5211718 Vasquez C. 61711 Veyries M. L. 4091365 Vassalo N. 255164 Vezina C. 450141 Vassas A. 2991266 Viala J. 1821288 289 294 1841471 Vassilev V. P. 218189 Viallefont P. 5191553 1-90 Natural Product Reports 1997 Viana K. E. 4091350 Vice S. F. 4291111 Vicente F. 256177 Vichnewski W. 1601189 Vick B. A. 1811205 Victory S.F. 475174 Vidal B. 406199 589148 49 50 Vidal M . 1841489 Vidales P. 659121 23 Vidaller A. 41 11455 Vidari G. 25517 2581236 237 5 161289 291 67611 7 Viden I. 1821275 1851612 Vidigal M. C. S. 731136 Viehe H. G. 660155 56 Vieira I. J. C. 741238 Vieira P. C. 731164 15812 61719 677181 Vieira R. F. 203124 Viel C. 401120 635179 Vieville C. 180198 Vigevani A. 109124 Vijayakumar E. K. S. 1821276 Vijayalakshmi P. 1821286 1841495 1861674 Vikersveen L. 1881820 Vila R. 514187 5161229 Viladomat F. 30311 8 20 Vilagines P. H. 30316 Vilagines R. 30316 Vilar E. T. 5201580 5211669 Vilches C. 555184 Vilcheze C. 3851190 Vilegas W. 475187 Vilela E. F. 96/32 677181 Villa L. 1861643 Villaescusa L. 731168 Villagomez-Ibarra R.159187 Villalgordo J. M. 5201623 Villamizar J. 159157 3001410 Villani G.,255115 3001412 3011422 Villanueva M. A. 5171353 Villar A, 1621317 475184 Villarreal-Rosales E. 1811206 Villaseiior J. L. 659121 23 Villeneuve P. 1881806 861 Vincieri F. F. 12/85 Vinckier C. 5191498 Vines D. R. 5181463 Vining L. C. 24211 74 175 176 372193 45 1/96 Vinogradova V. I. 405132 Vinson S. B. 1611236 Violante F. A. 71/43 Vioque E. 1831343 Viossat B. 3851143 Virden R. 3321136 Virgil S. C. 676111 Virsik P. A. 4091312 Virtuani M. 676117 Visco A. M. 5161300 302 Viset G.,462117 Visser D. 4091355 Visser D. T. V. 4091328 Viswajanani R. 1611290 Viswanathan S. 650150 Vita-Finzi P. 25517 2581236 616117 Vitart V.10197 Vitek A. 1861670 Viterbo D. 2571152 Viveros M. P. 4101410 Vlad P. F. 514177 78 Vladimir V. 4081228 Vladimirov S. 383125 Vlaskova M. 4091349 Vlasova L. M. 401148 635192 636195 Vlietinck A. 427117 Voehler M. 203144 Voelker T. A. 3571160 Voelter W. 82/37 39 44 48 50 51 383120 21 4101439 Voerste A. A. W. 20160 474143 Vogel B. S. 1431198 208 210 Vogel P. 39/17 33 635111 14 Vogeli U. 6031131 132 133 Voges R. 21716 218150 Vogler B. 1621314 Vogtli M. 554119 Vogy P. K. 109168 Voigt B. 9/13 38 50 1Ol101 3 8 51200 Voinov V. G. 4641110 Voitekhovskouya G. I. 5191514 Vokac K. 97/91 Volcho K. P. 5161305 5111383 Volhardt J. 159188 Volk K. J. 5561129 Vollack K.-U. 141122 32 Vollhardt K.P. C. 303125 Vollmer J. J. 2991253 Volpe A. 4101413 Volpe J. J. 356117 18 Volterra L. 463169 von Daehne W. 3311108 110 von der Zeijden A. A. H. 5201582 von Holleben M. L. A, 5171389 von Nickisch-Rosenegk E. 9619 von Poser G. L. 5151212 Von Radloff M. 82/74 von Reisen C. 5891106 107 von Rudloff E. 4521193 Von Wettstein-Knowles P. 35516 Vonwiller S. C. 1601138 Vorbrueggen H. 241119 384161 Vornam B. 9811 71 Vorobjev A. V. 2571194 Voronina T. A. 4091342 Voss G.,296151 Vostrowsky O. 3581191 51 51146 Voyer N. 6361107 Vneling K. 96/54 Vu C. B. 3913 Vu P. 5201598 Vuilhorgne M. 5901134 Vujaklija D. 55311 7 Vul’fson S. G. 5171381 Vulpetti A. 5181418 Vuong A. 5901137 Vurro M. 981153 154 155 Vyas D.M. 4291113 Vyglazov 0. G.,5191514 Vysotskii M. V. 1811178 181 2991324 W Wabel R. 4081215 Wacharotayankun R. 3321125 Wachi Y. 3581242 Wada A. 5211708 Wada H. 35111 73 Watzig H. 635169 Waddell T. G. 1621327 Wadhams L. J. 96/30 31 Wadouachi A. 635133 Wadsworth D. J. 5181481 5551123 Waegell B. 5191502 Waehaeliae K. 3851133 Wagle R. D. 1851606 Wagman A. S. 428177 Wagner C. 555155 Wagner G. 5211670 Wagner G. J. 1431195 201 202 35517 Wagner H. 2971124 427124 6791201 Wagner K. 384184 Wagschal K. 5161272 Wagschal K. C. 142196 107 108 5191489 490 Wagstaff D. J. 660178 Wahala K. 71/17 18 Wahala K. T. 71/41 Wahl A. 25711 72 Wahlburg H. C. 5161269 Wahlqvist M. L. 71116 Waibel R. 677168 Waigh R.D. 96/12 618168 6771105 Waight E. S. 371139 Wajner M. 4071132 Wakabayashi M. 4081237 Wakamatsu K. 2971150 Wakamatsu T. 721104 105,106 107 108 109 741219 223 224 52 11741 Wakefield D. H. 474138 Wakelin L. P. G. 108115 Wang J. J. 1611272 273 450118 Waters S. M. 4081209 Weller D. D. 4511107 Wakil S. J. 356114 15 16 27 54 4511115 117 5111394 Waterson D. 218181 Wells J. S. 331153 3511143 144 145 3581205 208 Wang J. L. 159l110 3011442 Watson A. A. 96/12 6511112 Wells R. J. 291l121 128 2991290 209 216 219 222 Wang J.-P.,20129 Watson A. T. 159164 2991256 46211 7 Wakisaka G. 109138 Wang J. X. 406187 4011135 Watson D. G. 6031142 Welmar K. 1601156 Wakisaka T. 9/14 Wang J. Z. 202/4 203146 Watson W. A. 255168 Welniak M. 5201577 Waksmunski F.S. 109149 Wang K. 4081259 Watson W. H. 256197 Wels C. M. 241161 Wakui Y. 11119 40512 Wang K. T. 218129 Watson-Wright W. M. 3011427 Welzel P.,110l102 105 Wakuri S. 4631103 Wang L. 406170 4101377 Watt A. P. 650139 47 Wen L. 1891899 Walasek Z. 5 171390 Wang M. 1611247 2991289 Watt J. W. G. 4081273 Wen R. 588132 Walavalkar R. 40192 4061117 5 1511 74 Watters D. J. 3011443 Wen Y. 6181155 Walchli M. R. 2911146 Wang M. A. 1611247 5111327 Watts R. M. 39125 Wen Y. R. 4081278 Walchli M. R. 463153 Wang M.-L. 2016 42118 9 I0 Wattwil M. 4091301 Wendel J. D. 1881847 Waldmann H. 428136 Wang P. 351l112 450127 33 35 Watzig H. 635169 Wender P. A. 588134 Waldmeier P. C. 406178 415176 6191230 Wauters J.-N. 58812 589155 Wendisch D. 1601185 1621321 Walker A. E. 218171 Wang P.H. 405134 Wautier J. L. 41 11453 255114 Walker E. A. 4101428 Wang Q. 1611248 Wawrzenczyk C. 5 14155 Wendt J. A, 635191 Walker E. C. 4101384 Wang R. F. 4081256 Wax R. G. 450/49 5551111 Wendt-Pienkowski E. 554139 Walker G. 3311122 Wang S. F. 618126 Wazir V. 255157 58 Weng H. 5211678 Walker J. V. 351l121 5561143 Wang S. H. 5201594 Weaner L. E. 1861644 Weng S. 635123 Walker K. 450170 Wang S. Q. 2561124 Webb G. 5561174 Wengel J. 12l121 131125 141233 Walker R. B. 40515 Wang T. 218118 589164 89 Webb H. 82/69 234 Walker R. J. 5891109 Wang T. L. 5191508 Webb J. S. 450183 Weniger B. 428188 6181180 197 Walker R. W. 356199 Wang T.-Z. 2911100 Webb N. 1831403 Wenkert E. 81116 Walker S. L. 109157 59 66 Wang W. 2981182 5141111 Webber S. E. 1801124 Wensley W. Y. 2581234 Wall M.E. 6791205 206 Wang W. Z. 1611225 Weber D. S. 96148 2191105 Wenz K. 1851582 Wallace E. M. 3001363 Wang X. 401113 1621320 4101372 Weber K. 1851600 1861679 Wenzel A. 6361119 Wallace J. C. 356124 5 13127 Weber L. 5191503 5201655 Were S. O. 659124 Wallace K. K. 450135 49 50 Wang X.-D. 1441250 Weber N. 1881852 Wernau W. C. 5551111 5551103 Wang X. F. 4091320 Weber S. 555154 Werner C. 372168 Wallace P. A. 1821282 284 356182 Wang X. K. 20213 4081226 Weber T. 141121 22 218137 55 Werner G. 1811156 Wallace T. W. 4291109 Wang X. R. 2561124 60U21 Wernerowska D. 255117 Waller D. P. 731140 Wang X.-S. 9/68 Weber W. 44915 Wernstedt C. 1441241 Waller G. R. 514197 Wang Y. 1431172 173 159155 Webster J. M. 42113 Wertz P. W. 1821249 Wallis A. F. A. 141242 2991250 4011128 134 4081219 Weeks G.356154 Wesolowska W. 5211723 Wallner P. 356155 5 19/51I Weerasuriya Y. 981149 Wessjohann L. A. 82149 Walls F. 159185 Wang Y. L. 406187 401l135 Weersurija A. 6191216 West C. A. 1431196. 214 240112 Walls J. T. 296119 Wang Y. T. 4091329 Weertunga G. 555157 241128 29 34 36 43 44 54 56 Wallsgrove R. M. 91176 77 Wang Z. 1431172 421121 22 Weete J. D. 1881855 78 79 80 81 602196 14211 I4 5211675 61811 55 Wehrli S. 3011493 West F. G. 401145 Walsh C. T. 4521185 Wang Z.-Q. 3841101 Wei B. 406168 West J. 1621318 Walsh M. C. 3511164 Wani M. C. 6191205. 206 Wei C. 589176 78 West J. M. 1421114 1431134 Walsh S. L. 4101429 431 Wanner M. J. 5111351 6511101 Wei D. 741255 Westberg H. 514158 Walshe N. D. A. 4291109 Wannigama G. P. 6191216 Wei F. 6781160 Westerling D.4101393 Walter F. 39164 Wanning M. 331174 Wei H. C. 1591112 Westermann J. 384172 5111322 Walter H. 5561158 Wanwimolruk S. 5891109 Wei H. X. 1611228 5181462 Walter J. A. 1841448 296163 64 Ward B. 109169 6031127 Wei J. M. 2511184 Westley J. W. 1841446 2981207 65 3011427 463138 70 Ward D. A. 1441222 226 2421105 Wei J. X. 1611226 5561202 553115 555192 5561153 108 122 Wei L. 401113 Weston R. G. 330134 Walter M. 3321128 Ward J. L. 2431198 Wei X. 406168 Wetzel J. M. 383116 Walter-Perotte D. 4101411 Ward J. M. 3321167 Wei Y. 356139 65019 Wey J. H. 161/225 Walters E. C. 4101403 Ward K. A. 96136 Weidenhamer J. D. 91l141 143 Weyerstahl P. 158114 159156 114 Walters S. J. 4101375 Ward 0. P. 1881877 879 144 159170 514169 117 1611269 1621352 5141103 Walther W.1861683 Ward R. A. 29811 71 Weidinger H. 1821271 5161235 236 Walton D. C.. 1431192 Ward R. S. 7111. 2 12l113 114 Weiergang I. 14U118 Weyland H. 296130 428159 Walton E. 330144 119 137 181 195 204 Weigele M. 331181 Wez U. 6781157 Walton N. J. 371112 Wardeh G. 4091325 332 359 Weigle M. 3311114 Wezel P. 1101107 Walton T. J. 981203 Warner G. F. 44914 Weil J. 312181 Whalley A. J. S. 182/239 wa Muanda M. 1841.501 Warner K. 3571112 Weiland J. 3851172 Whalley W. B. 240114 Wan H. 513127 Warnhoff E. W. 8117 Weinberger D. R. 4011200 Wha-Son B. 3321176 196 Wan P. J. 1841501 Warr S. M. 450123 Weinbrenner S. 428157 Wheeler P. R. 1821283 356171 97 Wanauppathamkul S. 1591118 Warren H. S. 39/51 Weiner R. M. 462123 98 Wandrey C. 218122 Warren S. 6361118 Weiner S.W. 1431147 Wheless K. 384174 Wang A. H.-J. 108112 14 18 19 Warthen Jr J. D. 911 Weingarten B. 4081260 Whitaker D. 5191525 22 Wasiak J. 5201584 Weinges K. 5181469 472 478 White A. F. 241137 57 2431197 Wang A.-Y. 356158 Wasicky M. 514185 51 51164 214 5211735 White A. J. P. 255151 Wang B. 4011127 137 139 Wasserman H. H. 3913 Weinmann H. 1621295 White A. R. 33016 7 Wang C. 11138 4011137 Wapmuth-Wagner I. 1611237 Weinstock L. M. 1831425 White C. 5181404 Wang C. W. 1881821 Wastila W. B. 406147 Weinstock M. 4101414 White D. J. 331163 Wang D. 5181415 616139 Watanabe A. 3511149 Weintraub J. D. 96116 White J. D. 1611255 1811211 Wang D. X. 4101426 Watanabe E. 5221786 Weintraub P. M. 3851139 296145 46 2911112 2991331 Wang E. L. 4511166 Watanabe G. 142170 71 15816 Weintritt H.2981217 46Z.5 463195 659114 I5 Wang F. 203131 51 91491 Watanabe H. 159175 1821266 Weir J. 242l112 White I.F. 981189 Wang F. P. 20211. 4 18 203119 46 474122 5 171331 Weiser J. 1601150 White J. J. 82/75 Wang F. S. 616120 Watanabe K. 159143 1601193 Weisleder D. 981201 1821304 305 White K. K. 911120 Wang G. 4081283 5151162 5111309 299132 7 3001385 405112 1811719 1891899 3581195 196 White R. 5561176 6111103 6181161 Watanabe L. Y. 406l110 Weisner P. 3511151 White R. H. 60U44 Wang G.-J.,9168 Watanabe M. 1611264 5191531 Weiss D. 384183 84 White R. J. 450185 88 451189 Wang G.-S. 6711102 Watanabe N. 131133 1611274 Weiss H. P. 383119 White R. L. 2191103 312193 Wang G.-Y.-S.,296132 3001352 463l101 5 161263 264 266 Weiss J. 4091323 White S. L. 635127 463126 Watanabe S.11/17 41 401l192 Weiss R. A. 39/37 White W. L. 651l110 Wang H. 311137 5 161264 Weissbart D. 1891902 Whitehead I. M. 601112, Wang H.-B. 72154 Watanuki T. 2911165 Weissenberg M. 384164 602125 6031134 137 Wang H.-J. 108110 109120 1601138 Watanabe Y. 39/70 219199 I00 Weissenborn D. L. 141145 6031136 Whitfield P. J. 20111 Wang H. L. 255139 Waterman P. G. 96/12 981164 175 Weissman G. 41 11452 Whiting D. A. 141213 225 226 Wang H. P. 2561124 176 1621293 333 2012. 3 4 8 Weizel P. 1101106 203122 Wang H. Y. 741259 1811750 759 731184 255127 414126 415152 66 Welburn A. R. 602150 Whitman D. W. 96121 Wang J. 203131 78 92 5 1314 514199 618168 Welch M. J. 3841126 3851140 Whitney J. G. 33011 Wang J. B. 39175 76 611l55 105 Welle R. 142154 601l11 602/45 Whitney J.L. 428193 Index of authors cited 1-91 Whitsett J. F. 1851585 Whittaker D. 5191535 Whittern D. N. 555197 Whitting A. 5201637 Whittle E. 3581236 Whyman R. 5891116 Whyte B. S. 110199 Wicha J. 2991321 3851208 Wichlacz M. 1601181 197 Wicki P. 406178 Wickramaratne D. B. 40711 78 475167 Widdowson D. A. 384169 Widener R. K. 2991331 Widlanski T. 4511119 Widmaier R. 602186 Widoso A. A, 5 161303 Wieczorek W. 5181434 Wiedenfeld H. 2571157 171 659129 31 Wiedmann M. 142180 Wiegand S. 4071186 Wiegrebe W. 40191 Wieland F. 3571142 Wiemer D. F. 159164 2991256 5 181459 650153 Wieruszeski J. M. 6781158 Wiese T. E. 3841105 Wiese W. 981171 Wiesenfeld-Hallin Z. 4091336 337 Wiesner P. 5561157 Wiesner R.1821245 Wiessler M. 660177 Wiggers F. T. 1601136 Wijayagunasekera H. N. P. 971105 Wijekoon W. M. D. 2971156 Wijerathne E. M. K. 255153 Wijeratne E. M. K. 4081213 Wijesundera R. C. 1861675 Wijnberg J. B. P. A. 1431194 16011 77 16 11244 1621332 Wikfors G. H. 463174 Wilcox A. L. 1851556 428181 3571181 Wilcox G. 71116 Wild K. D. 4101373 Wild S. 660171 Wilde J. 141147 Wilen R. W. 10183 Wiley P. E. 109182 Wilhelm H. 82173 Wilhelm J. W. 4101375 Wilkening R. R. 109188 Wilkins A. L. 428179 Wilkins C. L. 513126 Wilkins D. G. 4101396 Wilkinson C. R. 1811193 Wilkinson R. E. 14119 514155 Wilkinson S. G. 1811210 602143 Willadsen P. 356123 Wille G. 4291114 Willem R. 383111 Willemsen S. H. N. 4101412 Willenborg D.O. 39152 53 Willer J. C. 4101434 Willetts A. J. 372185 William D. J. 971102 1601127 Williams B. 3581211 Williams D. E. 2981187 3011433 618122 Williams D. H. 2971144 Williams D. J. 255151 5191519 554133 34 Williams D. R. 109156 3001356 35711 I3 Williams H. J. 1611236 5171363 Williams J. 2421125 Williams J. D. 109185 Williams J. M. 3841129 Williams J. P. 651195 96 Williams J. R. 3841106 107 108 Williams L. 82170 Williams L. A. D. 971102 1601127 Williams M. 40515 Williams M. D. 203127 28 2971169. 2981193 194 240 3011483 Williams R. M. 1431199 21711 2 21 8132 2571168 428164 Williams R. P. 450183 Williams S. C. R. 1871744 Williams S. F. 635147 Williams S. G. 3571140 514169 Williamson G.B. 971141 143 144 Willis C. L. 217114 218118 19 67 2191115 2411103 2421135 183 2431198 202 Willis R. G. 1851597 Willis R. H. 296131 Willker W. 401138 635189 Wills M. 2971152 Willuhn G. 1621321 255114 Willumsen A. M. 71124 Willumsen N. 1831415 Wilson J. W. 303123 Wilson R. H. 1861694 Wilson S. R. 383126 Wilson T. M.. 2431198 Wilson W. K. 3851188 Wilton H. 1611232 2991269 Wimp J. 3321186 372172 Winchester B. G. 635135 Windsor M. 241192 4071197 Wing R. M. 297199 Wink J. 651168 Wink M. 9619 97168 139 40l110 121 122 129 635177 659133 37 Winkler F. J. 21719 Winkler J. 2981198 Winkler J. D. 428176 Winkler R. G. 1441220 241186 Winne R. P. 4081265 Winneroski L. L. 4291108 Winstanley D. J. 3311116 3321164 Winterfeldt E.1621295 Winterhalter P. 158119 21 5211685 688 705 Winterhoff H. 40711 75 Wintoch H. 5171326 Winton P. L. 218118 19 67 Wipf P. 2981174 Wise M. L. 1811169 296179 35711 33 136 Wise R. 3311111 Wisedale R. 6361117 Wissenbach M. 35516 Witham P. 635122 36 Wititsuwannakul R. 141124 Witkowski A. 3581206 211 Witschel M. C. 1611283 Wittancock R. E. 981165 Witte L. 401104 121 126 96110 2981229 30312 17 311120 635173 75 76 77 78 659133 37 41 46 Witter D. J. 5561160 Witters K. D. 2191118 Witting D. A. 331160 Wittke O. 255149 Wnuk R. J. 450177 Woelfel S. K.. 406150 Woerdenbag H. J. 7115 35 Woerner F. J. 39140 Woggon W.-D. 372167 Wojcik J. 3861239 Wojtusik M. J. 1801107 1851590 Woldemariam T.Z. 428147 Wolf C. F. 450183 Wolf D. H. 3571146 Wolf E. 218184 Wolf F. 141138 Wolf F. J. 330134 Wolfender J. L. 1621357 5211747 Wolff C. 1601172 Wolff L. 3001380 Wolff R. L. 1871714 Wolff T. 4091288 Wolkowicz P. E. 1861697 Wollenberg K. F. 1871724 725 Wollenweber E. 676116 Woloshuk C. P. 5561161 162 Wolska I. 401139 635184 85 Wolski T. 474119 Wolter-Filho W. 589197 Wolthuis W. N. E. 2191117 Wong A, 33/21 7 Wong C. 10814 Wong C. F. 1831347 1861703 Wong C.-H 218188 89 Wong K. C. 5151190 Wong K. P. 1821287 1831384 385 386 401 Wong M. Y. H. 356191 Wong S.-M. 5891109 Wong W. 450114 Wongpanich V. 405135 Woo S. J. 4071157 Wood A. 671183 Wood A. I. 296131 Wood D. L. 96135 Wood E.J. 1441242 Wood J. L. 4291117 119 120 450114 5901130 131 Wood K. 981149 384185 Wood K. V. 677174 Wood S. E. 971142 Wood S. G. 589180 Woodcock C. M. 96130 31 Woodgate P. D. 255144 2561112 Woodin T. S. 3571185 Woodruff H. B. 330133 43 4511167 Woods A. M. 4101385 Woods D. L. 142194 Woods J. H. 4091348 4101416 424 428 Woods N. 1621345 Woodside A. B. 602171 72 Woodward R. B. 331151 Woodward R. W. 2191108 Woodward W. R. 4081207 Woolley J. G. 371111 I2 Worden E. 513149 Workman J. 97/79 Worley J. F. 911 Wormald M. R. 6511112 Woroniecki S. R. 331170 3321162 163 173 3331215 Worsham L. M. S. 3571140 Wrasidlo W. 2571183 Wray G. A. 46213 Wray V. 2981229 4521187 553110 5561149 6781130 146 6791202 Wretensjo I.1871768 Wrigglesworth R. 650138 Wright A. D. 1591119 255124 297191 119 120 2991292 42712a 42811 04 5 171348 5221750 803 6771106 Wright A. E.. 159150 2981242 2991259 Wright D. A. 4511109 Wright J. J. 1821277 Wright J. L. C. 1841448 1871745 296163 64 65 3001392 3011427 463138 70 555192 5561153 Wright S. L. 1811172 Wright S. W. 1831335 Wu B. 2561123 5211710 Wu C. L. 1591103 112 2991276 Wu D. 1611246 2571213 6791218 Wu D. P. 159144 WU F.-E. 20216 Wu G. 5211710 Wu H. 2571209 2991294 3001357 428161 6781150 Wu H. M. 158126 2561108 2971132 2991274 6781137 139 I45 Wu J. 3851201 4071129 130 136 Wu J. B. 474135 475160 WU J.-P. 463141 Wu J. Z. 2561120 Wu K. 1441225 241192 2421121 123 Wu K. Y. 6771107 Wu L.5191552 Wu M. 5 17/33 7 Wu M. H. 4061104 WU P.-L. 20145 42718 9 10 61715 13 618153 71 Wu S. 5171313 6361103 105 Wu S. J. 4071165 WU S.-J. 20115 61718 19 Wu S. L. 1601199 Wu S. S. 72/51 71/27 Wu S. T. S. 4511156 Wu T.-K. 3331218 372169 WU T.-S. 2016 15 45 67 42718 9 10 5891127 61715 13 19 618153 73 650126 61 8/71 Wu T. S. 4071165 450122 Wu W. L. 1821332 1831333 651184 Wu Y. 1431172 5201654 Wu Y. C. 40111 77 WU Y.-C. 71142 Wu Y. L. 1821332 1831333 WU Y-L. 5181479 Wu Z. 1431141 148 150 450173 5171337 Wuerthwein E-U. 5211672 Wiinsche C. 4511147 148 Wurst K. 588130 Wurst M. 1851612 Wurz G. 731167 Wurzel G. 2971169 Wu-Won J. J. 2991329 Wyllie S. G. 5171356 Wynne B. 4071194 Wyns L.383111 32 Wysocka W. 401108. 137 140 149 635172 87 Wysokinska H. 513150 51 5211725 Wythes M. J. 218181 Wyvratt M. J. 109149 X Xavier M. T. 39134 Xi Y. 4071143 Xi Z. 5 181451 5 191524 Xia G. 406183 4071140 141 Xia G. J. 406188 Xia Y. 159155 2991250 514159 Xia Z. 1431172 173 406142 Xia Z.-Q. 371127 Xiang R. 406142 Xiang Y. 406175 Xiao C. 384177 Xiao P. 406170 Xiao P. G. 406159 616138 6781191 Xiao X. 5191552 5201613 Xiao Z. 5191575 Xie F. Z. 159171 Xie H. 406168 Xie S. 406170 Xie W. 2561146 Xie W.-G. 39129 635118 19 Xie X.-Q. 635164 Xie Y. S. 97194 Xie Z. 35517 5171307 Xing J. 406173 Xingwen W. 474147 Xiong Z. 1611245 Xu B. Q. 4101400 Xu C. R. 677152 63 Xu D. 5161290 Xu G.72191 4101391 Xu G. J. 741216 217 203143 Xu H. 47417 Xu J. 203127 28 2981191 192 193 3011483. 406142 6771103 6781161 170 XU J.-D. 6771102 6791212 240 XU J.-P. 3011484 5221761 Xu L. H. 1611253 256189 Xu M. 2561120 Xu Q. 406186 Xu R. 4071153 650143 44 676146 6781150 170 XU R.-S. 203133 475176 5221761 67711 07 Xu S. 474118 Xu S. X. 474131 32 XU S.-C. 650117 18 Xu X. 4641108 5171388 Xu X. X. 159181 Xu Y. 5151145 XU Y.-L. 1441225 241192 2421123 Xu Y. M. 256192 Xu Y. Z. 65017 Xu Z. 1821303 Xuan J. W. 602193 Xuan L. J. 256192 1-92 Natural Product Reports 1997 Xuang B. 4071128 161 163 165 166 167 168 170 Yang Y. 3311118 Yoon H. S. 1871778 Xue H. 741215 2561144 145 Yang Y. M. 1871752 756 475l100 Yoon K.3851147 Xue H. Z. 731140 Yamane S. 659113 Yang Z. 141145 463148 6031136 Yoon K. S. 618136 Xue Q. 1431151 152 Yamane T. 1881820 842 844 Yang 2. X. 1431171 Yopp J. H. 5/64 66 67 Xue Y. 4111461 5151202 589195 65 1/99 Yangisawa T. 10189 Yorita K. 731174 Xue Z. C. 406185 Yamasaki K. 731148 2571206 Yanniou C. 5 151194 Yosef R. 660148 5221784 58818 677156 57 Yano I. 356190 Yoshida H. 981146 6781132 147 Yano M. 1821328 Yoshida J. 5181401 Yamasaki N. 5181432 Yano S. 1601149 256183 Yoshida K. 731132 296167 Y Yamasaki Y. 255160 635137 Yao B. 159l110 Yoshida M. 72/87 93 731136 147 Yamashita K. 72/53 Yao M. 158115 16 741236 265 16 11233 3001393 Yabe K. 5561163 165 Yamashita M. 29711 70 2981222 Yao W. 406184 4071140 141 I42 Yoshida N. 2571159 428152 Yada Y.1431158 Yamashita Y. 255156 Yao W. K. 406188 Yoshida S. 721116 176 178 191 Yadav J. S. 180195 1821308 325 Yamauchi N. 372186 Yao X. 406175 90 474118 199 2561136 143 296125 5211676 1831344 5 171336 Yamauchi T. 40190 731150 Yao X. S. 474131 32 Yoshida T. 331155 463150 Yadav J. S. 72/68 80 1601183 2421165 168 170 255176 Yaoita Y. 1611281 282 5181440 5201593 6791242 Yadav M. R. 3861233 2561144 145 635159 60 Yaozu C. 20215 Yoshida W. 463162 Yadav N. S. 3571177 Yamauchi Y. 1861650 Yartseva I. V. 40711.55 Yoshida W. Y. 2981173 190 221 Yadav R. M. 3861234 Yamaura T. 1431144 Yarygin V. N. 4091345 283 300141 7 418 451 428192 Yadav S. J. 2571153 Yamaura Y. 5181424 Yasuda A. 218165 650113 Yoshida. Y. 3001402 4641116 Yadava R. 4751101 Yamazaki H. 1441230 2561140 Yasuda H.1621337 1861682 6361131 65 1/86 Yadava R. N.. 6791233 Yamazaki K. 6511103 Yasuda I. 1621302 Yoshihara K. 9/10 5 171355 Yadava V. S. 475148 Yamazaki M. 2421147 4751102 Yasumoto T. 296166 69 71 Yoshihara T. 1811220 Yafin Y. 241132 475194 2971115 167 3011428 429 492 Yoshii E. 3001349 Yagi A. 1611274 4631101 5161263 Yamazaki R. 41 11449 3571119 463142 43 44 77 Yoshikawa K. 741235 241 243 266 Yamazaki S. 513113 5561141 6781134 Yagihashi M. 1621353 3001341 Yamazaki T. 218185 3311115 Yasuta E. 911 7 Yoshikawa M. 5171347 5191488 Yaguchi E. 6781166 Yamazaki Y. 241173 Y atagai M. 5 14/61 5221766 677151 6781148 153 178 Yaguchi S. 5221804 Yan B. F. Y. 1841438 1871736 739 Yates J.. 5901137 179 Yahara S. 731161 203140 5221796 741 Yazaki K. 371135 Yoshikawa Y. 1851547 Yakhontova L.D. 4071155 Yan C. C. 660166 67 68 69 70 71 Yazawa K. 1881882 296132 463126 Yoshiki Y. 6771119 Yaksh T. L. 4081268 269 Yan G. 5201627 103 6361129 Yoshimitsu H. 203140. 676145 Yakushijin K. 65017 Yan H. D. 4091299 Ye T. 67811 71 Yoshimura E. 2581241 2991280 Yamabe S. 3311115 117 Yan M. 142167 Ye W.-C. 67811 71 Yoshimura H. 405112 Yamada F.. 2981214 428167 Yan R. N. 1591110 Ye Z. 5191538 Yoshimura T. 1851530 3851156 Yamada H. 1881869 870 871 872 Yan S. 475174 Ye Z. L. 6771120 Yoshinaga I. 5561134 874 875 876. 219l100 428134 Yan S.-T. 61718 Yeager M. P.. 4091323 Yoshino H. 2561131 132 Yamada J. 1861655 Yan W. 406183 Yee L. N. 5161282 Yoshino T. 5211733. 6771112 Yamada K. 981148 2571218 296132 Yan X. 406190 5 1511 73 Yefremov Y. J. 1851561 Yoshioka H.6031126 2971150 1.51 3001376 402 403 Yan Z. Q. 1611234 Yeh A. I. 1861651 Yoshioka K. 5171325 404 405 406. 407. 428150 463126 Yanagi K. 554122 Yeh H. J. C. 40/83 Yoshioka M. 1431216 4641116 588125 6361128 Yanaginuma E. 5181424 Yeh J.-H. 20145 617113 Yoshizawa Y. 1431144 145 Yamada M. 356144. 3571130 131. Yanagisawa T. 9154 10190 94 Yeh S.-T. 39/74 1441249 1611287 5561160 5171329 5561194 Yanagisawa Y. 411157 Yeh W. L. 2991295 5191522 523 Yoshizumi S. 6781153 Yamada O. 3011438 Yanaihara. N. 303118 Yeong S. K. 1881821 Yotsui Y. 6361131 Yamada S. 3011461 462. 3861219 Yanase N. 589167 Yesilada E. 255125 5221789 Yotsu-Yamashita M. 29711 15 427118 Yang A. 2981212 Yet L. 1611241 297193 5181464 30 1I492 Yamada T. 296140 384160 428154 Yang B. H. 1611253 256189 Yeung B.K. S. 159149 2981190 You K. 1821290 4631107 67711 12 6791212 240 2991260 428192 You K. K. 40182 88 Yamada Y. 1851587 2571211 Yang C. 5211726 5221756 757 765 Yeung C. H. 39/49 YOU,K.-S. 3581248 2971165,299l316 320 3001359 793 676139 6791218 Yeung C. M. 2571174 You M. 4071178 3011492 3581239 240 241 Yang C.-C. 555173 Yeung K.-S. 29811 71 You T. 5201654 3851207 Yang C.-J. 3841101 Yi D. K. 4091296 You X. 5161259 Yamagami K.. 731207 1881882 Yang C.-P. 39142 Yi N. 406142 YOU Y.-T. 401116 117 Yamagishi T.. 71/44 Yang C-R. 5221784 677159 Yi Y. 6781172 You Z. 3851148 4091353 Yamaguchi H.. 72/48 6781132 6791235 Yiannikas C.,4081210 Youji S. 408121 7 Yamaguchi I. 9115. 56 2421160 Yang C.-S. 741248 Yim H. Y. 4071157 Young B. Y. M. 4071124 161 170 Yang C.S. 159l110 Yin S. 1431143 Young D. C. 3841109 Yamaguchi K. 3011428 428153 Yang C. X. 1611253 Yin W. K. 5211737 Young D. W. 2 1717 2 18/60 61 62 463153 103 Yang C.-X. 6771112 6791212 Ying B. P. 158138 5211675 63 64 90 91 92 219193 94 106 Yamaguchi N. 158124 296176 Yang D. 108114 109118 Ying N. 5171307 107. 112 113 241121 296159 60 Yamaguchi. S.. 241148 Yang D.-J. 428180 Yocklovich S. G. 1861656 Young J. C. 1861653 Yamahara J. 5171347 5191488 Yang D-M. 5221777 Yoden K. 1851531 Young K. A. 296160 5221766 677151 6781148 153 178 Yang G. 1431151 5181482 5201613 Yoganathan K. 588138 39 589175 Young M. G. 331154 179 Yang G. C. 1851526 76 78 79 I03 Young R. N. 1801123 Yamakawa K.. 1611261 Yang H. 5221793 Yokochi T. 1851548 1861654 655 Young S. J. 4071135 Yamamiya Y.384159 Yang H. O. 741260 1591108 1881873 Young T. H. 406139 Yamamoto D. 3011441 Yang J. 159161 62 4061118 Yokoh M. 677194 Young W. B. 2561149 Yamamoto H.. 1431183 158134 35 408121 7 4091339 Yokoi T. 2571156 Yousefi M. J. 5191495 4101370 5201653 555163 64 Yang J.-P. 2971148. 3001381 67614 Yokoo C. 2991316 Yousif G. 7118 Yamamoto I. 405112 Yang J. S. 741259 Yokota T. 912 8 12 13 14 15 17 Yu C. 82/33 Yamamoto J. 5181428 Yang L. 731162 1611225 1621292 18 22 28 29 31 32 33 34 35 Yu C.-M. 3001392 Yamamoto K. 2 8 11151 152. 5 1 51163 5 191558 36 37 39 40 41 42 44 45 51 Yu C. T. 4091323 1871761 762 769 297192 3861219 Yang M. 5 171334 53 54 55 57 58 60 61 62 64 Yu D. Q. 159171 6781135 189 190 Yamamoto R. 514168 Yang P. R. 1601130 66 67 10185 86 87 89 90 91 Yu H.F. 406177 Yamamoto S. 555160 Yang S. 41 11461 92 93 94 218182 3851200 Yu J. 462114 Yamamoto T. 2981222 Yang S.-C. 6791220 Yamamoto Y.. 296175 3001335 Yang S. J. 406187 Yokouchi C. 109131 Yu M. 159173 85 3001333 650154 Yokoyama A. 296135 36 2981227 67618 677169 5 181430 5201636 463129 Yu Q. T. 1871748 749 750 751 Yamamura H. I.. 4101423 Yang S. S. 1831367 Yokoyama K. 142159 756 759 770 Yamamura S. 2971146 3011420 Yang T. 5201613 Yamamura T. 1431145 Yang T. J. 5191501 5201605 609 Yonaha K. 21715 Yu R. S. 5211727 Yoneda M. 450181 Yu S. 5191491 Yamamuro M.. 72157. 741240 611 612 Yoneda R. 428141 Yu S.-M.,72/67 Yamanaka J. 731159 Yang T.-K. 39/74 Yamanaka M.. 41 11449 Yang X. 406183 Yonemitsu M. 255161 Yu S. S. 6781189 190 Yamanaka T. 731178 Yang X.B. 159l110 6781176 Yonemitsu O. 5181424 YU S.-X. 65013 Yamanauchi T. 5221796 Yang X. S. 255154 YOO,H.-D. 296144 45 Yu T.-W. 4511123 127 Yamanchi T. 971113 Yang X.-S. 203120 YOO,I.-D. 618125 Yu X. 141145 6031136 Yamane H. 1431213 241147 48 60 Yang X. W. 74/21 7 474123 Yoo J. S. 2571169 4081272 Yu X. J. 1871750 759 2421114 128 149 152 153 160 Yang X.-W. 741216 Yoon C. H. 5211734 Yu Y. 5561166 Index of authors cited 1-93 Yu Z.-L. 677152 Yuan Y. 5191510 Yuan Z. 450134 Yuasa H. 6111113 114 Yuasa K. 158115 5221786 Yue E. W. 5561126 Yue Q. 25711 67 Yue X. 3001351 Yuen K. H. 1601135 Yuhara T. 65913 Yuksel I. 635171 Yulizar Y. 6791207 Yun J. S. 3001396 Yun S.-J. 618136 Yun Y. 428150 51 Yunes R. A. 61113 Yunker M.B. 67611 Yunusov M. S. 4011180 Yunusov S. Y. 6511100 Yurawecz P. 1851526 Yurdaydin C. 4101384 Yuruker A. 5221750 751 803 Yusem G. J. 1841502 Yusuf A. 514176 Yusupov M. K. 4011176 4101440 Yusupov M. M. 406160 65 111 Yuthavong Y. 1591118 5181485 Yuumoto Y. 651171 Z Zabriskie T. M. 602173 Zacchino S. A. 141249 Zading J. E. 4091313 321 Zaghoul M. G.,5221802 Zagorski M. G. 4521190 5561148 Zaharia O. 3331202 Zahir A. 428149 Zahner H. 331174 75 44915 4511140 169 170 5561132 65912 Zaidi N. A. 1881822 Zaidlewicz M. 5171390 Zajac J. M. 4081256 Zajicek J. 1431198 Zakaria A. D. D. 4091338 Zakomyrdina L. N. 218126 Zakszewski T. B. 4101375 Zalewska T. 4101423 Zalkin H. 4511112 113 114 Zalkow L. H. 407l191 659138 39 Zalman F.G. 96137 Zamir L. O. 2511154 155 Zamora R. 1831343. 402 1851557 Zamorano G. 1601184 Zampanella A. 4641115 Zampella A. 18 11213 29811 79 Zanardi F. 63413 Zanatta N. 82143 Zang G. L. 4071148 Zang H. 4111450 Zangerl A. R. 97171 72 Zanirato V. 650140 Zanocchi A. M. 25517 Zanoni G. 5161291 Zapardiel A. 40511 Zaparucha A. 3851143 Zapp J. 1601175 1611246 255172 Zaragoza R. J. 5211698 Zarapkar S. S. 1611267 Zarga M. A. 1611256 Zasloff M. 3011493 Zauner I. 5561157 Zavarin E. 513138 Zavodnik N. 2991308 Zavozin A. G. 4751108 Zav’yalov S. I. 41511 08 Zaw K. 6791205 Zawadowski T. 415180 Zdero C. 1611278 Zeches M. 20112 82126 47 Zedk U. 617159 Zeeck A. 331174 44915 6 44916 4511140 143 144 156 157 161 555187.93 5561132 651168 65912 Zeevaart J. A. D. 1431193 1441225 241184 85 90 92 2421119 121 123 139 140 141 155 159 2431198 Zefiro N. S. 1591109 Zeikus J. G. 1811185 Zeiler S. 141122 Zen R.,384191 Zeng L. 428161 676115 671171 72 73 74 Zeng L. M. 158126 1621351 2561108 2911132 2991274 3001352 384 Zeng T. 4071142 Zeng W. 4011140. 141 Zeng X. 6181136 Zeng Z. 109161 Zenk M. H. 371121 26 27 28 29 30 31 33 36 602158 Zennie T. M. 65012 Zepeda 1. G. 1601145 Zepeda L. G. 5181483 Zerbes R. 82174 Zerlin M. 555195 Zerng T. 406184 Zernig G. 4101428 Zgombic-Knight M. 1441237 238 Zha Z. 5211710 Zhabinskii V. N. 3851202 Zhai D. 218132 Zhai Y. 1441239 240 Zhai Z-X. 5201618 Zhakina A.K. 401146 147 Zhamyansan Y. 401101 Zhan B. 5191513 Zhang A. 96140 Zhang B. 514159 Zhang C. 650145 Zhang D. 142186 87 88 463130 602167 6781131 173 Zhang D.-C. 741246 Zhang F. 4081283 Zhang G. L. 405115 Zhang H. 2571165 3001389 390 5151202 21 I 5 181453 58911 09 6 17112 Zhang H. C.,406174 Zhang H.-C. 2981185 Zhang H. J. 2511166 676121 Zhang H. L. 428189 Zhang H.-L. 731183 Zhang H.-P. 3001393 Zhang J. 406176 90 5191491 5201647 67811 72 6791218 Zhang J. S. 4061109 4071152 153 Zhang J. Y. 1811748 749 750 751. 752 756 759 770 Zhang J.-X. 203133 Zhang J. Z. 2571162 Zhang L. 141242 Zhang M. 2561120 2511209 3001357 406180 89 4091329 611112 6181128 Zhang M. H. 406181 Zhang M. Z. 616121 Zhang P.428137 55 56 5201598 Zhang Q. 4091336 Zhang R. 20214 203131 46 676115 6171115 6781159 I76 Zhang R.-M. 401112 116 117 Zhang S. 3581246 406190 5 151166 Zhang S.-X. 141246 Zhang S-Z. 5151168 169 170 Zhang W. 5111309. 310 51 81466 ~!21793 Zhang X. 108116 14311 71 45 111 II 5191511 Zhang X.X. 4011145 Zhang Y. 2991288 4071134 41 11461 Zhang Y.-J. 6791235 Zhang Y.-L. 11128 29 Zhang Z. 82170 255154 Zhang Z.-H. 3321181 Zhang Z. P. 2571157 171 Zhao A. H. 1611226 Zhao B.-T. 203120 Zhao C. 6111103 Zhao D. 1621351 618123 Zhao G. 5151210 Zhao J. 1891899 Zhao L. 406175 Zhao M. 4061118 Zhao M-W. 5221761 Zhao P. 677159 Zhao R. 5901136 Zhao R-B. 5181479 Zhao S K. 4081220 Zhao S+X. 4081219 6781171 175 Zhao T.F. 20213 Zhao W. 676146 6181170 Zhao W. M. 5211727 Zhao Y. 1611277 1621292 406170 Zhao Y-F. 5181479 Zhao Y. Y. 6711111. 115 6781159 Zharova E. V. 4091345 Zhavsan S. 401101 Zhen Q. T. 2561123 Zheng H. 635156 67811 72 Zheng K. 5191513 Zheng L. 5171309 310 Zheng N. 463171 Zheng Q. 3001362 406188 Zheng Q. Y. 741266 2561107 2571181 Zheng S. 3011426 618123 Zheng S. Z. 676128 Zheng W. 463141 Zheng Y. F. 1831364 365 1841436. 43 7 Zheng Y. L. 1611254 Zherdev V. P. 4091342 Zhernosek E. V. 3851202 Zhgenti N. Zh. 218123 Zhi B. X. 1601158 Zhi Y. P. 2511212 Zhi-da M. 255162 Zhmyrko T. G. 1821262 263 Zhong M. 4751116 Zhong Y. 428161 Zhong Y. L. 158126 1621351 2561108 2971132 2991274 Zhonkhozhaeva F.B. 1621324 Zhou B.-N. 6181137 138 139 140 141 142 143 144 145 Zhou C. 218140 5201627 Zhou D. 602144 Zhou F. 14311 72 173 Zhou J. 109179 67811 75 Zhou J. Y. 2571160 5171313 Zhou J.-B. 677176 Zhou L. 255119 Zhou P. 4511116 5201648 Zhou Q. 406185 5551116 Zhou Q.-L. 121111 Zhou Q. T. 4071143 Zhou R.-H. 6791222 Zhou T. 5 151145 Zhou W. 4081283 41 11450 Zhou W.-S. 39129 5211697 635118 Zhou W.-Z. 635119 Zhou X. 5551116 Zhou X.-M. 11127 Zhou Y. 5151173 635165 676130 Zhou Z. 4071134 Zhou Z. H. 2571154 155 47417 Zhou Z. L. 2561120 Zhu C.-B. 555147 Zhu D. Y. 4011152 Zhu G.-D. 386121 7 Zhu J. 96139 91167 Zhu M. 406168 Zhu Q. 141131 Zhu T. R. 474144 5171345 Zhu W. 617116 Zhu X. 650144 Zhu X.X. 3851155 Zhu Y. 5141111 Zhu Y-X. 241166 2421138 Zhu Z. Y. 677164 6781135 Zhuang H. 1851558 Zhuang Z.-P. 5901130 I31 Zhubanov K. A. 5181400 Zhurinov M. Z. 401146 147 635193 Zian Q. 5151202 Ziboh V. A. 1801138 Ziegler G. 1821267 Ziegler H. 1821267 514160 5211735 Ziegler J. 5 181399 Ziering D. L. 3571125 Ziffer H. 1601139 Zijlstra R. W. J. 5181409 Zimmer H. 721100 Zimmer R.,635120 Zimmerly V. A. 450180 Zimmerman S. B. 330133 45 Zimmerman W. 33 1/61 Zimmermann M. P. 1841451 452 3571127 128 Zina C. 5171389 Zinchenko S. V. 6181185 Zing G. F. 5211687 Zini G. 2561151 Zink D. L. 15817 1591101 256177 Zinsmeister H. D. 475190 91 Zivanov-Stakic D. 383125 Zmitrovich A. C. 4101430 Zoebelein H.180191 Zoghbi M. D. G. B. 72181 Zolke C. 555154 Zoller U. 5211679 Zollo F. 296118 2991315 3011476 479 480 481 ZOIIO,P-H. A. 514186 5151205 Zoltewicz J. A. 3011488 489 Zomaya I. I. 331189 97 101 103 Zonno M. C. 981153 Zook M. 981174 Zook M. N. 6031129 Zoorob G. K. 5221812 Zoretic P. A. 2991288 289 Zorumski C. F. 3851151 152 Zou K. 6781159 Zou P. 5191.558 Zu Z. Q. 475172 Zuanazzi J. A. 58817 6511102 Zubaidha P. K. 5181445 Zuccaro P. 4091318 Zuckerman L. A. 4091289 Zucolotto M. 5171389 Zulaica E. 588126 43 44 Zulueta M. C. A. 25513 Zurek D. M. 10170 77 78 81 Zuurbier K. W. M. 60118 Zvartau E. E. 4091290 Zwagerman D. Q. 406196 Zyabhtskii V. M. 4071126 Zydowsky T. M. 452i192 Zyglado J. A. 5151157 175 179 5161228 238 240 1-94 Natural Product Reports 1997

ISSN:0265-0568    

DOI:10.1039/NP99714000I1

出版商:RSC    

年代:1997

数据来源: RSC

ISSN:0265-0568    

DOI:10.1039/NP997140X003

出版商:RSC    

年代:1997

数据来源: RSC

ISSN:0265-0568    

DOI:10.1039/NP99714BX007

出版商:RSC    

年代:1997

数据来源: RSC

摘要:

Quinoline quinazoline and acridone alkaloids Joseph P. Michael Centre for Molecular Design Department of Chemistry University of the Witwatersrand Wits 2050 South Africa Covering July 1994 to June 1995 Previous review 1995 12 465 1 Quinoline alkaloids 1.1 Occurrence 1.2 Non-terpenoid quinoline and quinolinone alkaloids 1.3 Prenylquinolines and hemiterpenoid tricyclic alkaloids 1.4 Monoterpenoid and sesquiterpenoid quinoline alka- loids 1.5 Furoquinoline alkaloids 1.6 Dimeric quinolinone alkaloids 1.7 Decahydroquinoline alkaloids 2 Quinazoline alkaloids 2.1 Isolation 2.2 Structural and synthetic studies 3 Acridone alkaloids 3.1 Occurrence and structural studies 3.2 Synthesis and biological studies 4 References 1 Quinoline alkaloids 1.1 Occurrence Five new quinoline alkaloids were reported during the period covered by this review.Table 1 lists these alkaloids together with known alkaloids isolated from new sources.'-16 In a study of the alkaloidal content of about thirty Penicillium species isolated from food sources the occurrence of viridicatin 1 was confirmed in only two organisms P. palitans and P. viridicaturn.' 1.2 Non-terpenoid quinoline and quinolinone alkaloids A new quinolin-2-one alkaloid 3,4,8-trimethoxyquinolin-2-one 4 has been isolated from the aerial parts of the Australian shrub Eriostemon gardneri.' The compound which was fully characterized with the aid of IR UV 'H NMR and I3CNMR spectroscopies is unique amongst the trimethoxyquinolin-2- ones in having an oxygen substituent at C-3 a position that is normally either unsu bsti tuted or prenylated.Ph 0 H 1 viridicatin 2 R=H; n=14 5 R=OMe; n=6 6 R=OMe; n=5 7 R=OMe; n=4 8 R=OMe; n=12 3 4 9 toddaquinoline The three homologous 2-alkylquinolin-4( 1H)-ones 5-7,iso-lated from the trunk bark of the Amazonian plant Esenbeckia almawillia,' were fully characterized with the aid of standard spectroscopic techniques. The only other 2-alkylquinolin-4-one alkaloid known to possess an 8-methoxy substituent is 1-methyl-2-tridecyl-8-methoxyquinolin-4( 1H)-one 8 reported in 1990 from another Esenbeckia species E. leiocarpa. Several new syntheses of 2-arylquinolin-4( 1 H)-one alkaloids are summarized in Scheme 1.The carbonylation of the 2-nitrochalcone 10 catalysed by triruthenium dodecacarbonyl and the new bis(imine) ligand 11 gave mixtures of 2-arylquinolin-4-ones and their 2,3-dihydro analogues 12.l9 The twelve examples reported include two alkaloids Table 1 Isolation and detection of quinoline alkaloids" Species Alkaloid Ref. Aralia biuinnata Dictamnine 51 1 Skimmianine 52 Boronia algida 1-Methyl-2- pentadecylquinolin-4-one 2 Boronia coerulescens spp. Dictamnine 51 spinescens Boronia inornata Dictamnine 51 Evolitrine 53 Isodictamnine 54 Citrus macroptera Isoplatydesmine 40 5 ( f)-Ribalinine 41 Dictamnus dasycarpus 7,8-Dimethoxymyrtopsine 6 42 7,8-Dimethoxyplatydesmine 43 y-Fagarine 55 Platydesmine 44 Ephedra spp.' 6-Hydroxykynurenic acid 3 7 Eriostemon gardneri 3,4,8-Trimethoxyquinolin- 8 2-one' 4 Esenbeckia almawillia 2-Heptyl-8-methoxy-1- 9 methylquinolin-4-one" 5 2-Hexyl-8-methoxy- 1 - methylquinolin-4-one" 6 8-Methoxy-1-methyl-2- pentylquinolin-4-one' 7 Evodia fatraina Evolitrine 53 10 Evodia rutaecarpa Atanine 45 11 Fagara zanthoxyloides y-Fagarine 55 12 (cell cultures) Skimmianine 52 Sarcomelicope megistophylla Acronycidine 56 13 Acronydine 57 ( -)-Sarcomegistine' 58 Vepris heterophylla Evolatine 60 14 Kokusaginine 61 Tecleaverdoornine 62 Zanthoxylum simulans Toddaquinoline 9 15 Zanthoxylum usambarense (+)-N-Methylplatydesmine 16 46 "Only new alkaloids and new records for a given species are listed.'Ephedra altissima E. distachya E. foeminea E. foliata and E. fragilis. 'New alkaloids. Michael Quinoline quinazoline and acridone alkaloids 2-phenylquinolin-4-one 13 and norgraveoline 14. Both 13 and 14 were amongst five 2-arylquinolin-4-ones prepared by a high-yielding oxidation of the 2,3-dihydro analogues 12 with iodobenzene diacetate.20 The cyclization of 0x0-amide 15 with a low-valent titanium reagent generated in situ from titanium trichloride and zinc afforded 2-phenylquinolin-4-one 13 in 56% yield probably via a titanium enolate." The hydrochloride salt of the same alkaloid was produced in two steps by hydrog- enolysis of the isoxazole 16 over Raney nickel followed by heating of the resulting vinylogous amide 17 in acidic ethanol- water solution.22 Vinylogous urethanes 18 underwent thermal cyclization at 300 "C to yield analogues of 13 bearing methoxy substituents in ring B.23 0 10 0 OCOMe R=H 57:43 R,R=OCH20 40:60 11 / 13 R=H 12 14 R,R=OCH20 It 85% for 13 78% for 14 v 65% for 13.HCI c- \ \NHCOMe 89% \ NHCOMe 17 16 EtOZC 11 ArNH% 18 Scheme 1 Reagents i CO (30atm) Ru~(CO),~ (l%) 11 (3%) EtOH-H,O 170°C; ii PhI(OAc), KOH MeOH 60°C; iii TiCl, Zn THF reflux; iv Raney Ni H3BO3 dioxane; v 1 M HCl in EtOH-H2O (1 :2) 90 "C Two short routes to the anti-leishmania1 quinoline alkaloid chimanine D 19 are illustrated in Scheme 2.24 Since direct epoxidation of 2-(prop- 1-enyl)quinoline 20 was complicated by formation of the heterocyclic N-oxide an indirect method for epoxidation was investigated.Treatment of 20 with N-bromosuccinimide (NBS) and water produced a bromo-hydrin which underwent cyclization to chimanine D 19 in 44% yield upon reaction with sodium hydroxide in propan-2-01. The dibromide 21 was formed as a by-product (22%). In an alternative synthesis of the alkaloid the reaction between quinoline-2-carbaldehyde 22 and the sulfonium ylide derived from triethylsulfonium tetrafluoroborate yielded a mixture of chimanine D (51%) and its cis isomer 23 (42%). New synthetic 12 Natural Product Reports 20 I i ii 44% + 22% 1 19 chimanine D Br 21 aCHO 22 I iii 51% + 42% 1 19 23 24 R=CeHs 25 R=CO*Et 26 R = COzCHzC02Et Scheme 2 Reagents i NBS dioxane-H,O room temp.; ii Pr'OH NaOH (1 M); iii Et3S' BF,- KOH MeCN-H,O 60 "C then 22 MeCN 60 "C analogues of chimanine D include the phenyl compound 24 obtained in 45% yield by the bromohydrin route and the two esters 25 and 26 prepared in 32.5% and 14% yields respect- ively by Darzens condensation between aldehyde 22 and ethyl chl~roacetate.~~ 1.3 Prenylquinolines and hemiterpenoid tricyclic alkaloids In last year's review an important new approach to the enantioselective synthesis of hemiterpenoid quinoline alkaloids involving the resolution of bromohydrins via their correspond- ing (+)-methoxy(trifluoromethy1)phenylacetyl esters (MTPA or Mosher's esters) was described.'*' Boyd and co-workers have now applied this resolution procedure to bromohydrins derived from 3-prenylquinolines 27 (Scheme 3)." Bromohy-drins 28 were made by opening the corresponding racemic epoxide derivatives of 27 with gaseous hydrogen bromide.Compounds 29 and 30 the diastereomeric Mosher's esters of 28 were then separated by multiple elution preparative thin- layer chromatography. The 2'R absolute stereostructure of the crystalline isomer (+)-29 was determined crystallographically. Compound 29 was converted in four steps into (+)-(2'R)- lunacridine 31 thereby confirming a tentative assignment of the alkaloid's absolute configuration made over 20 years ago.26 The non-crystalline Mosher's ester 30 was converted in analo- gous fashion into ( -)-lunacridine ent-31.When the pre- nylated quinoline 32 was subjected to the above procedure the outcome was more complex. The 2-benzyloxy group of the initally formed racemic epoxide was also cleaved on treatment with hydrogen bromide giving the racemic quinolin-2-one bromohydrin 33. Mosher esterification of this product yielded not only the expected diastereomers (+)-(R)-34 and ( -)-(9-35 but also the tricyclic derivatives (+)-(S)-36 and ( -)-(R)-37. Transformations of some of these products into (R)-8-methoxyplatydesmine 38 (3-8-methoxyplatydesmineent-38 and (+)-(S)-9-methoxygeibalansine 39 are illustrated in Scheme 3. OMe OMe OMe OMe OMe OMe OMe OMe 27 28 29 30 v-viii 16% v-viii 15% 1 1 e,::!l-..i,i1dr-\ @w \ 51% OH \ OH \ OH OBn I I I OMe OMe H OMe Me OMe Me 32 33 31 (+)-(2'R)hnacridine ent-31 (-)-(2's)-lunacridine I iii iv ix 42% 21Yo ,-I-? r--l \ \ @r+ OMTPA e\ r OMTPA + q\ y y P A + @JyyA I I OMe H OMe H OMe OMe 34 35 36 37 v iv 31% v iv 34% 1 1 OMe OMe OMe OMe OMe OMe 38 enf-38 39 Scheme 3 Reagents i MCPBA CH2Cl, sodium hydrogen phosphate buffer (1 M pH 8) 0 "C to room temp.; ii HBr (g) Et20 0 "C; iii (+)-MTPA-chloride DMAP (cat.) pyridine room temp.; iv multiple elution preparative TLC; v KOBut THF reflux; vi BH,.THF LiBH, 0 "C then H,SO,-THF room temp.; vii HCl (g) Et,O room temp.; viii MeI K,CO, Me,CO reflux; ix semi-preparative HPLC (Zorbax sil); x KOH MeOH room temp.The known alkaloid atanine 45 has been isolated for the first time from Evodia rutaecarpa a plant used in the traditional Chinese medicine 'wuzhuyu'.' The alkaloid was located by activity-guided fractionation against the sheep nematode Ostertagia circumcincta; the purified alkaloid was also shown Me to be active against larvae of the human parasite Schistosoma H 46 mansoni and against the soil nematode Caenorhabditis elegans.45 atanine These are the first reports of atanine's antiparasitic and anthelmin tic activity . 1.4 Monoterpenoid and sesquiterpenoid quinoline alkaloids The cytotoxicity of the new monoterpenoid quinolinone alka- loids zanthosimuline 47 and huajiaosimuline 48 which were described in last year's review,'" has been in~estigated.'~ Zanthosimuline elicited a general cytotoxic response when evaluated with a variety of cultured human cancer cell lines and cultured P-388 cells.Huajiaosimuline produced a Me Me more selective profile of cytotoxic activity and was especially 40 isoplatydesmine 41 ribalinine R' @-OH R' 42 R1 =OMe; R2=OH 43 R1 = OMe; R2 = H Me Me 44 platydesmine R1 = R2 = H 47 zanthosimuline 48 huajiaosimuline Michael Quin0 line qu inazoline and acr idone alkaloids effective with the estrogen receptor-positive breast cancer cells ZR-75-1. Both compounds were able to induce the expression of cellular markers associated with cell differentia- tion in cultured HL-60 cells but only huajiaosimuline showed significant antiplatelet aggregation activity. Cytochromes bo and bd two terminal respiratory oxidases found in Escherichia coli and many other bacteria catalyse the oxidation of ubiquinol by molecular oxygen.It has recently been shown that the sesquiterpenoid quinolinone alkaloid aurachin C 49 is an extremely potent inhibitor of the quinol oxidation sites of both enzymes; binding appears to be far tighter than that of any previously described inhibitors known to affect the quinone binding Aurachin D 50 is also a highly effective inhibitor of cytochrome bd. I R 49 aurachinC R=OH 50 aurachin D R = H 1.5 Furoquinoline alkaloids ( -)-Sarcomegistine 58 occurs with several known furoquino- line and acridone alkaloids in the aerial parts of the New Caledonian tree Surcomelicope megistophyllu. ' The structure of this new alkaloid was established with the aid of spectro- scopic data that included COSY DEPT heteronuclear multi- ple quantum correlation (HMQC) and heteronuclear multiple bond correlation (HMBC) NMR experiments and by corre- lating the chemical shifts of I3C NMR signals with those of related dihydrofuroquinoline alkaloids such as perfamine 59.The presence of a free hydroxy group was confirmed by the formation of a monoacetate derivative on treatment with acetic anhydride in pyridine. The absolute configuration was not determined. The isolation of sarcomegistine is inter- esting from a chemotaxonomic viewpoint because the only other known alkaloids possessing the rare ring B oxidized furo[2,3-b]quinoline system occur in the genus Huplophyllum. In vitro cell culture of Fugaru zunthoxyloides a West African tree used in traditional medicine has been reported for the first time.Both benzophenanthridine and furoquinoline alkaloids were isolated from cultures the levels of the latter remaining high even after several months of subculture. Levels of y-fagarine 55 which has apparently never been isolated from intact I; zanthoxyloides plants decreased with time as levels of skimmianine 52 increased thus supporting the notion that 55 is a biosynthetic precursor of 52. The production of furoquinoline alkaloids as well as acri- done epoxides can be elicited in in vitro cultures of Rutu graveolens by challenging the cultures with a homogenate of the yeast Rhodotorulu rubra2* Alkaloid promotion seems to occur by stimulation of anthranilate synthase which biases the biotransformation of chorismate towards the branch of the shikimic acid pathway responsible for the production of anthranilic acid-derived metabolites.Oxymercuration of acrophylline 63 with mercuric acetate in water-THF followed by treatment with sodium borohydride yielded acrophyllidine 64 (73%).29 When tested for antiallergic responses both compounds were found to reduce the volume of plasma exudate in mice suffering from oedema of the ear though apparently by different mechanisms. Skimmianine 52 and to a lesser extent kokusaginine 61 and confusameline 65 act as antagonists at the 5-HT2 receptor site for the neurotransmitter 5-hydroxytryptamine (serotonin) in isolated membranes of the rat cerebro~ortex.~' 14 Natural Product Reports OMe I R3 51 dictamnine R1 = R2 = R3 = H 52 skimmianine Ri = H; R2 = R3 = OMe 53 evolitrine R1 = R3 = H; R2 = OMe 55 y-fagarine R1 = R2 = H; R3 = OMe 60 evolatine R1 = OMe; R2 = OCH2CH(OH)C(OH)Me2; R3 = H 61 kokusaginine R1 = R2 = OMe; R3 = H 65 confusameline R1 = R3 = H; R2 = OH 0 OMe OMe \ I I Me OMe MeO-54 isodictamnine 56 acronycidine 57 acronydine R OMe OMe OMe 58 sarcomegistine R = OH 62 tecleaverdoor nine 59 perfamine R=H 0 0 1 OH 63 acrophylline 64 acrophyllidine 1.6 Dimeric quinolinone alkaloids The synthesis of dimeric quinolinones by Diels-Alder cycloaddition of dienes such as 66 was previously described in a comm~nication~~ [cf ref.18(d)]. An amplified report of this work has now been published with full experimental details.32 Palladium-catalysed coupling of iodoquinolin-2-one 67 with 2-methylbut-3-en-2-01 has been improved by strict temperature control to yield diene precursor 68 (73%) rela- tively free of the by-products that were isolated in the earlier work (Scheme 4).Dehydration of 68 with acetic acid con- taining concentrated sulfuric acid for 2 h at room tempera- ture yielded viu the detectable diene 66 a mixture of the Diels-Alder dimer 69 (27%) a previously undescribed dimer 70 (34%) and N-methylflindersine 71 (12%). When the reac- tion time was increased to 48 h 69 was no longer found; instead 70 (34.5%) was accompanied by the dimer 72 (33%). It was shown in a separate experiment that dimer 69 could be converted quantitatively into 72 on leaving it to stand in the acidic medium for one day.The stereochemistry of 72 previously undetermined was elucidated with the aid of X-ray crystallography. Compound 70 underwent base-induced hydrolysis and rearrangement probably via the ring opened intermediate 73 to give 74 (97%) the structure of which was also determined crystallographically. Me Me I I - I I Me Me 67 68 I 66 ii or/iii -Me -\ I IV Me J OAc 0 V I 97% 70 74 Me 71 Scheme 4 Reagents i H,C=CCMe,OH Pd(PPh,),Cl, CuI NEt, DMF 85-90 "C 3 h; ii HOAc H,SO, 2 h; iii HOAc H,SO, 48 h; iv HOAc H,SO, 24 h; v aq. NaOH (1 M) EtOH room temp. 1.7 Decahydroquinoline alkaloids Analysis of 'Bohlmann bands' which occur in the IR region between 2800-2600cm-' has been used to elucidate the relative stereochemistry at three of the four stereogenic centres in several decahydroquinoline alkaloids isolated from the skins of dendrobatid frogs.33 The technique works because 2,6-cis- disubstituted piperidine rings show significant Bohlmann bands whereas the trans isomers do not.The effect depends on the dihedral angle between the nitrogen lone pair and a-CH bonds and on the number of a-hydrogen atoms that are trans-antiparallel to the lone pair. Using cis-fused alkaloid 195A 75 -also known as pumiliotoxin C -and three of its synthetic epimers as reference compounds the authors were able to assign the stereochemistry of a new alkaloid extracted from the skin of the Peruvian frog Epipedobates bassleri as trans-195A 76.The relative stereochemistry at C-5 remains unknown. The relative stereochemistries of five other recently isolated34 decahydroquinoline alkaloids from amphibian skin were similarly determined. A new synthesis of ( f)-pumiliotoxin C rac-75 by Mehta and Praveen makes use of regioselective Haller-Bauer cleav-age of the readily available Diels-Alder dimer 77 with sodium hydroxide solution (Scheme 5).35 Esterification of the cleaved products afforded a 3:7 mixture of the epimers 78 and 79 without competitive isomerization of the double bond into conjugation. After a sequence of standard functional group transformations on 79 Beckmann rearrangement of the oxime derived from ketone 80 gave the bicyclic lactam 81 containing three of the four stereogenic centres of the target alkaloid.The remaining stereogenic centre was introduced by treatment of imino ether 82 with propylmagnesium bromide followed by a facially selective reduction with diisobutyl- aluminium hydride. The final product was characterized as its hydrochloride salt. Michael Quinoline quinazoline and acridone alkaloids The synthesis of ( -)-pumiliotoxin C 75 by Kibayashi and co-~orkers~~ took advantage of an intramolecular Diels-Alder cycloaddition that occurred spontaneously when the chiral hydroxamic acid 83 was oxidized with periodate (Scheme 6). In non-aqueous medium the acylnitroso inter- mediate 84 was converted into a mixture of two adducts 85 and 86 with relatively poor diastereoselectivity (1:1.4).How- ever the ratio of the latter product was increased substan- tially (1:4.5) in aqueous medium. After catalytic hydrogena- tion of 86 the propyl side chain adjacent to nitrogen was introduced completely stereoselectively by addition of propyl- magnesium bromide followed by reduction with sodium cyanoborohydride. The oxazine ring of 87 was cleaved by hydrogenolysis to give the 2,6-cis-dialkylpiperidine 88 after which functional group interconversions and aldol condensa- tion afforded the enone 89. Catalytic hydrogenation of 89 occurred exclusively from the less hindered p face to establish the cis-fused decahydroquinoline ring system in 90. Unfortu-nately the C-5 methyl substituent emerged with the incorrect configuration.On the basis of finely argued conformational arguments the N-benzoyl protecting group was reduced to the corresponding N-benzyl equivalent before base-induced epimerization was attempted. The best ratio of the ensuing products 91 and 92 was 1.2:l. Prolonged heating with zinc trifluoromethanesulfonate followed by ethanedithiol induced further epimerization and a single thioacetal 93 was isolated in 66% yield. The synthesis of (-)-pumiliotoxin C 75 was completed as illustrated. The first asymmetric synthesis of a trans-decahydroquinoline alkaloid (+)-2 19A 94 has been reported by Comins and Dehghani (Scheme 7).37In this new variation of the well-known Comins methodology for alkaloid syn- thesis the chiral N-acylpyridinium salt 95 was converted in five steps into the 2,6-cis-disubstituted piperidinone 96.The trL HI H 76 trans-1 95A 0 65% (3:7) 0 77 78 79 iii-viii 24% J xi- ix x - 65% HI H 82 81 80 xii xiiil45% HI H rac-75 pumiliotoxin C Scheme 5 Reagents i NaOH (aq. l%) (36 room temp.; ii CH,N, Et,O 0 "C; iii HOCH,CH,OH p-TsOH C,H, Dean-Stark appara- tus then chromatography on SiO,; iv LiAlH, THF reflux; v CBr, PPh, CH,Cl, 0 "C to room temp.; vi H (1 atm) 10% Pd-C EtOAc room temp.; vii NaBH,CN HMPA 80 "C; viii aq. HCl; ix NH,OH.HCl NaOAc MeOH room temp.; x p-TsC1 NaOH H,O- dioxane 5 "C to room temp.; xi Me,O' BF,- Et,NPr' CH,Cl, 10 "C; xii PrMgBr C6H6 reflux; xiii DIBAL CH,Cl, -78 "C bicyclic nucleus was created by oxidative cleavage of the alkenyl group of 96 followed by intramolecular aldol con-densation to yield 97.The stereogenic centre at C-5 was introduced by stereoselective conjugate addition of a higher- order cuprate followed by trapping of the resulting enolate as the vinyl trifluoromethanesulfonate 98. The alkene 99 derived from 98 by palladium-induced hydrogenolysis followed by deacylation underwent stereoselective hydrogenation to give a mixture of trans-and cis-fused quinolines 100. Separation of the isomers was left until after replacement of the OH groups by phenylseleno substituents the major product being the trans compound 101 (87:13). From this isomer the synthesis of (+)-trans-219A 94 was completed as illustrated.2 Quinazoline alkaloids Developments in the chemistry of quinazoline alkaloids over the period 1986 to July 1993 have been reviewed by Johne in a recent supplementary volume to Rodd's Chemistry of Carbon Compounds.38The same supplement includes a review of recent syntheses and reactions of pyrimidines and quina~olines.~~ 2.1 Isolation 2-Acetylquinazolin-4(3H)-one102 has been isolated from a culture broth of the mycoparasitic fungus CZadobotryum varium together with several a-pyrone and amino acid derivative^.^' 83 84 85 + 96% \ \ 87 86 I Me ,..A I HI OH COPh COPh 88 89 71% xi xii 4 73% (1.2:l)'&..,A HI COPh 91 90 + n CH2Ph ' ' CH2Ph 92 93 xiv vil 63% Me IH m.-.-HI H 75 (-)-pumiliotoxin C Scheme 6 Reagents i Pr,NIO, H,O-MeOH (6:1) 0 "C; ii H, 10% Pd-C THF room temp.; iii PrMgBr THF O"C then NaBH,CN AcOH THF 0°C; iv Zn AcOH (aq.85%) 60°C; v PhCOC1 CH,CI, K2C03 (aq. lo%) then KOH; vi H, 10% Pd-C MeOH room temp.; vii PCC CH,Cl, room temp.; viii KOH MeOH 0 "C; ix KHSO, MeOH room temp.; x H, 10% Pd-C 1 M HC1 room temp.; xi LiAlH, THF reflux; xii (COCI), DMSO CH,CI, -90 'C then NEt, room temp.; xiii Zn(OTf), CH,Cl, reflux 4d then (CH,SH), reflux 4 d; xiv Raney Ni dioxane reflux A new investigation on a well-studied Indian medicinal plant Adhatoda vasica has yielded four known alkaloids ( -)-vasicine 103 ( -)-vasicinone 104 ( -)-vasicol 105 and anisotine 106 as well as two new natural prod-ucts 3-hydroxyanisotine 107 and vasnetine 108.4' 3-Hydroxyanisotine was previously known as a synthetic com- pound prepared by oxidation of anisotine with potassium permanganatee4* All the compounds isolated in this study were characterized with the aid of an unusually comprehensive range of 'H and I3C NMR experiments.In fact this publica- tion indubitably contains the definitive NMR data (S and J values) for pyrrolo[2,1 -b]quinazoline alkaloids. The authors 16 Natural Product Reports 9 X C02R C02R C02Ph 95 R = (+)-frans-2-102 103 (-)-vasicine R = OH X = H,H I (a-cumyl)cyclo hexyl V 79% 104 (-)-vasicinone R = OH; X = 0 111 deoxyvasicine R = H; X = H,H 113 peganol R = H; X = H,OH 114 deoxypeganidine R = H; X = H,CH2COMe I I C02Ph C02Ph 97 96 viii ix 182% C02Ph H 98 99 I 'H ArAe W S e A r xiii-xv 63% (+ 10% cis) HI HI C02Bn H 101 100 xvi xvii 187% HI H 94 (+)-219A Scheme 7 Reagents i H2C=CH(CH,),MgBr toluene-THF -78 OC then radial PLC; ii NaOMe MeOH then aq.HCl (10%); iii BuLi; iv PhOCOCl; v BnO(CH,),MgBr CuBr BF,-OEt, -78 "C; vi OsO (cat.) NaIO,; vii p-TsOH C,H, 52 "C;viii [BnO(CH,),],CuCNLi,; ix N-(5-chloro-2-pyridyl)triflimide; x HCO,H Bu,N (Ph,P),Pd(OAc),; xi KOH Pr'OH reflux; xii H, 5% Pt-C Pd(OH), EtOH; xiii BnOCOCI NaOH; xiv K,CO, MeOH; xv o-NO,PhSeCN Bu,P CH,Cl,; xvi H,O (30%) THF; xvii Na NH, THF ascribed the variability in published optical rotations for ( -)-vasicine to oxidative conversion into vasicinone.Investigation of the epigeal parts of Nitraria komarovii has yielded two new pyrrolo[2,1 -b]quinazoline alkaloids deoxy- peganine N-oxide 10943 and peganine N-oxide l10.44 In addition to the customary spectroscopic characterization chemical confirmation of the structure of 109 was provided by reduction with zinc and hydrochloric acid which afforded a compound identical in all respects to authentic deoxypeganine (=deoxyvasicine) 111. Similarly reduction of 110 yielded peganine (=vasicine) 103 and a small quantity of deoxypega- nine. Other quinazoline N-oxides from the same plant were described in last year's review.I8" A new quinazolinocarboline alkaloid (+)-7-hydroxy-rutaecarpine 112 has been isolated from the heartwood ,of Tetradium glabrifolium (=Evodia meliaefolia) and the fruit of T.r~ticarpum.~~ The gross structure was elucidated by means of full spectroscopic analysis. The axial orientation of the 7-hydroxy group was inferred from the small coupling con- Michael Quinoline quinazoline and acridone alkaloids dqR OH OH QC02Me KQ NHMe 105 vasicol 106 anisotine R = H 107 3-hydroxyanisotine R = OH q/Q R 0 108 vasnetine 109 R=H 110 R=OH BrqcDQd& HO H -OMe 115 112 stants between H-7 and the adjacent hydrogen atoms on C-8. The absolute configuration of the new alkaloid was not determined. 2.2 Structural and synthetic studies Unambiguous 'H and 13C NMR assignments for a range of quinazolin-4(3H)-ones and their corresponding 4-thiones should be useful in future structural elucidations of quin- azolinone alkaloids of this class.46 X-Ray crystallographic analyses have been reported for dehydroxypeganine and hydrochloride dih~drate~~ the peganine-zinc chloride complex,48 as well as for several tetramethylene and pentam- ethylene analogues and their derivative^.^^ Peganolll3 has been converted into deoxypeganidine 114 in 30% yield upon heating with anhydrous copper sulfate and acetone." In view of the pharmacological potential of vasicine analogues the novel brominated analogue 115 of deoxyvasi-cine was synthesized from 2-amino-5-bromovanillin and 4-aminobutyraldehyde for studies on structure-activity relationships.5' Danishefsky and co-workers have devised a three-step syn- thesis of the reverse-prenylated hexahydropyrroloindole sys- tem 116 from bis(tert-butoxycarbony1)tryptophanmethyl ester 117.52Compound 116 was an intermediate in the synthesis of several alkaloids including the quinazolinones ardeemin 118 and N-acetylardeemin 119 the latter having importance as a potent agent for reversal of multiple drug resistance in human tumour cell lines.The central feature of these syntheses was an efficient (72%) intramolecular variant of the aza-Wittig reac- tion as exemplified by the conversion of 120 into ardeemin 118 (Scheme 8). Boc 117 116 i ii/71yo 120 v 72% 1 118 ardeemin R = H 119 5-Kacetylardeernin R = Ac Scheme 8 Reagents i FCN pyridine CH2CI, -15 “C; ii D-Ala- OMe-HCl NaHCO, H20 CH,C12; iii TMSI MeCN O’C then NH, DMAP MeOH; iv KHMDS o-N,C,H,COCI THF -78 “C; v Bu,P C,H,; vi LDA THF -78 “C to room temp.then AcCI reflux 3 Acridone alkaloids 3.1 Occurrence and structural studies The new alkaloids isolated during the review period (Table 2) include four members of the rapidly growing family of acridonexoumarin dimers. Roots of the Citrus hybrid ‘Yalaha’ (a cross between the Duncan grapefruit C. paradisi and C. tangerina the Dancy tangerine) yielded representative examples of three distinct classes of dimer.53 Acrimarine-N 121 was isolated as an optically inactive oil. Like all the other acrimarines it incorporates the coumarin suberosin linked in this case through C-1’ of its prenyl side chain to C-2 of the known acridone alkaloid citpressine-I1 122.In ( -)-neoacrimarine-E 123 the acridone moiety is natsucitrine-I1 124. The most interesting new compound is (+)-dioxinoacrimarine-A 125 which is the first doubly-bridged acridone-coumarin dimer to have been isolated from a natural source. The 1,4-dioxane ring connecting the acridone and coumarin nuclei has been encounted previously only in the acridone-lignan dimer acrignine-A 126.Isf All the new alka- loids were characterized spectroscopically with HMBC 18 Natural Product Reports Table 2 Isolation and detection of acridone alkaloids“ Species A1 kaloid Ref. Citrus hybrid ‘Yalaha’ Acrimarine-Nb 121 53 (+)-Dioxinoacrimarine-A’ 125 ( -)-Neoacrimarine-E’ 123 Citrus paradisi ( f)-Citbismine-A’”127 54 (+)-trans-Dihydroxycitracridone-55 Ib 129 Furoparadine’” 128 55 Marshdineb 130 56 ( -)-Marshmine’ 131 56 Sarcomelicope Melicopidine 132 13 megistophylla 1,2,3-Trimethoxy-N-methylacridone 133 “Only new alkaloids and new records for a given species are listed.’New alkaloids. 0 OH A Me0 OMe Me 121 acrirnarine-N OMe k 122 R=Me 124 R=H 0 OH 123 neoacrirnarine-E experiments proving especially valuable in establishing con- nectivities through 2J and 3J correlations. The absolute configurations were not determined. Five new alkaloids have been isolated from the roots of the grapefruit variety Citrus paradisi. Citbismine-A 127 is the first example of a bis(acridone) alkaloid in which the two units are linked by a C-C bond between aromatic and dihydrofuran rings.54 Its gross structure and relative stereochemistry were unequivocally established by X-ray crystallographic analysis after NMR experiments failed to reveal the positions of all substituents.Furoparadine 128 is the first example of an acridone alkaloid possessing the rare furo[2,3-c]acridone nucleus to have been found in the genus Structures for the remaining new alkaloids (+)-trans-dihydroxy-citracridone-I 129,55 marshdine 13056 and ( -)-marshmine 131,56were relatively easily determined by modern spectro- scopic methods. The absolute configurations of 129 and 131 were not established. 0 OH OMe ? %0 Me 125 dioxinoacrimarine-A 0 OH OMe 126 acrignine-A 0 OH OMe H 127 citbismine-A 0 OH 0 OH \ / 0 N OMe Lo he 130 marshdine 131 marshmine 0 OMe Me OMe 132 melicopidine The X-ray crystal structure of the prototypical acridone alkaloid 9( 1OH)-acridone has been determined.57 Intermo- lecular hydrogen bonding between NH and O=C groups and Michael Quinoline quinazoline and acridone alkaloids 7c-7c interactions are the dominant factors controlling the packing of molecules in the crystal lattice.3.2 Synthesis and biological studies Treatment of the acridone alkaloid noracronycine 134 with lithium aluminium hydride or alkyl- and aryl-lithiums in diethyl ether at room temperature or above yielded the 7-substituted o-quinone methides 135 (9-750/0) as blue solids.58 When 1-hydroxy-3-methoxy-N-methylacridone136 was the substrate the analogous purple o-quinone methides 137 were isolated (25-90%).Since neither acronycine 138 nor the dimethoxy compound 139 reacted with alkyllithiums it is likely that lithiated intermediates such as 140 are involved the subsequent reaction presumably then proceeding by addition of the nucleophile to the carbonyl group followed by dehydration. The quinone methide products have potential as alkylating agents for antitumour therapy; their reactivity towards nucleophiles was demonstrated by the formation of 141 (60%) and 142 (74%) when 137 (R=Bu) was treated with methyllithium and lithium aluminium hydride respectively. Thio thioacetyl oxime hydrazone and azine derivatives of acronycine 138 have been prepared from the parent alkaloid and the configurations about the C=N bond in the nitrogen derivatives have been elucidated by NMR spectroscopy.59 Several acronycine analogues obtained by methylation of the corresponding noracronycine precursors with iodomethane- sodium hydride showed weak activity against a variety of tumour cell lines.60 The experimental antitumour activities chemical synthesis and structure-activity relationships of the alkaloids acronycine 138 and glyfoline 143 have been described in a review that highlights their activity against leukaemia and three different murine solid tumours.61 0 OR Me Me 133 R' = R* = OMe 134 noracro nycine R = H 136 R' =OH; R2 = H 138 acronycine R = Me 139 R' = OMe; R2= H RO I II 135 R = H,Me Bu Ph 4-Me2N-C6H4 (CH2)3NMe2 I Me 137 R = Bu 4-Me2N-C6H4 (CH&NMe2 140 Bu R OH 0 OH \ / OMe HO OMe Me Me0 Me OMe 141 R=Me 142 R=H 143 glyfoline 4 References 1 J.-J.Hsaio H.-T. Liu and H.-C. Chiang Chin. Pharm. J. (Taipei) 1994 46 199 (Chem. Abstr. 1995 122 51 360). 2 S. D. Sarker J. A. Armstrong and P. G. Waterman Phytochem-istry 1995 39 801. 3 M. Ahsan J. A. Armstrong S. Gibbons A. I. Gray and P. G. Waterman Phytochemistry 1994 37 259. 4 M. Ahsan J. A. Armstrong A. I. Gray and P. G. Waterman Phytochemistry 1995 38 1275. 5 E. Gaillard F. Muyard F. Bevalot A. Regnier and J. Vaquette Ann. Pharm. Fr. 1995 53 75 (Chem. Abstr. 1995 122 286 672). 6 T.-S. Wu M.-L. Wang H.-J. Shyur Y.-L. Liu Y.-Y. Chan C.-M.Teng and S.-C. Kuo Chin. Pharm. J. (Taipei) 1994 46 447 (Chem. Abstr. 1995 122 235 236). 7 S. Caveney and A. Starratt Nature 1994 372 509. 8 S. D. Sarker P. G. Waterman and J. A. Armstrong J. Nut. Prod. 1995 58 574. 9 G. M. S. P. Guilhon A. C. S. Baetas J. G. S. Maia and L. M. Conserva Phytochemistry 1994 37 1193. 10 N. Ravelomanantsoa P. Rasoanaivo and M. Delmas Biochem. Syst. Ecol. 1995 23 339. 1I S. Perrett and P. J. Whitfield Planta Med. 1995 61 276. 12 E. Couillerot C. Caron L. Comoe J.-C. Audran P. Molinatti M. Zeches L. Le Men-Olivier J.-C. Jardillier and J.-C. Chenieux Phytochemistry 1994 37 425. 13 A,-L. Skaltsounis L. Sedrati F. Tillequin M. Koch J. Pusset and T. Sevenet Nut. Prod. Lett. 1995 5 281. 14 E. T. Gomes S.Travert J. Gleye C. Moulis 1. Fouraste and E. Stanislas Planta Med. 1994 60 388. 15 1.-S. Chen S.-J. Wu 1.-L. Tsai T.-S. Wu J. M. Pezzuto M. C. Lu H. Chai N. Suh and C.-M. Teng J. Nut. Prod. 1994 57 1206. 16 A. Kato M. Moriyasu M. Ichimaru Y. Nishiyama F. D. Juma J. N. Nganga S. G. Mathenge and J. 0.Ogeto Phytochem. Anal. 1995 6 89. 17 T. A. Reshetilova T. F. Solovyeva B. P. Baskunov and A. G. Kozlovsky Food Addit. Contam. 1995 12 461. 18 J. P. Michael Nut. Prod. Rep. (a) 1992 9 25; (b) 1995 12 468; (c) 1995 12 470; (d) 1995 12 82; (e) 1995 12 472; (f)1995 12 86. 19 S. Tollari S. Cenini F. Ragaini and L. Cassar J. Chem. Soc. Chem. Commun. 1994 1741. 20 0. Prakash D. Kumar R. K. Saini and S. P. Singh Synth. Commun. 1994 24 2167.21 A. Fiirstner A. Hupperts A. Ptock and E. Janssen J. Org. Chem. 1994 59 5215. 22 S. Jensen and K. B. G. Torssell Acta Chem. Scand. 1995 49 53. 23 J. Toda T. Fuse E. Kishikawa N. Ando R. Negishi Y. Horiguchi and T. Sano Heterocycles 1994 38 2091. 24 M.-H. Munos J. Mayrargue A. Fournet J.-C. Gantier R. Hoc- quemiller and H. Moskowitz Chem. Pharm. Bull. 1994 42 1914. 25 S. A. Barr D. R. Boyd N. D. Sharma T. A. Evans J. F. Malone and V. D. Mehta Tetrahedron 1994 50 11 219. 26 R. M. Bowman G. A. Gray and M. F. Grundon J. Chem. Soc. Perkin Trans. I 1973 1051. 27 B. Meunier S. A. Madgwick E. Reil W. Oettmeier and P. R. Rich Biochemistry 1995 34 1076. 28 J. Bohlmann and U. Eilert Plant Cell Tissue Organ Cult. 1994 38 189. 29 A.-C.Huang T.-P. Lin S.-C. Kuo and J.-P. Wang J. Nut. Prod. 1995 58 117. 30 J.-T. Cheng T. K. Chang and I.-S. Chen J. Auton. Pharmacol. 1994 14 365. 31 C. F. Neville S. A. Barr and M. F. Grundon Tetrahedron Lett. 1992 33 5995. 32 S. A. Barr C. F. Neville M. F. Grundon D. R. Boyd J. F. Malone and T. A. Evans J. Chem. SOC. Perkin Trans. I 1995,445. 33 H. M. Garraffo L. D. Simon J. W. Daly T. F. Spande and T. H. Jones Tetrahedron 1994 50 11 329. 34 T. Tokuyama T. Tsujita A. Shimada H. M. Garraffo T. F. Spande and J. W. Daly Tetrahedron 1991 47 5401. 35 G. Mehta and M. Praveen J. Org. Chem. 1995 60 279. 36 M. Naruse S. Aoyagi and C. Kibayashi Tetrahedron Lett. 1994 35 9213. 37 D. L. Comins and A. Dehghani J. Org. Chem. 1995 60 794. 38 S.Johne in Rodd’s Chemistry of Carbon Compounds ed. M. F. Ansell Elsevier Amsterdam 1995 Suppl. to the Second Edn. vol. IV parts I/J ch. 46 p. 223ff. 39 D. T. Hurst in Rodd’s Chemistry of Carbon Compounds ed. M. F. Ansell Elsevier Amsterdam 1995 Suppl. to the Second Edn. vol. IV parts I/J ch. 43 p. 63ff. 40 Y. Tezuka Q. Huang T. Kikuchi A. Nishi and K. Tubaki Chem. Phurm. Bull. 1994 42 26 12. 41 B. S. Joshi Y. Bai M. S. Puar K. K. Dubose and S. W. Pelletier J. Nut. Prod. 1994 57 953. 42 R. R. Arndt S. H. Eggers and A. Jordaan Tetrahedron 1967 23 3521. 43 T. S. Tulyaganov Chem. Nut. Cmpds. Engl. Transl. 1993 73. 44 T. S. Tulyaganov Chem. Nut. Cmpds. Engl. Transl. 1994 30 727. 45 T.-S. Wu J.-H. Yeh P.-L. Wu K.-T. Chen L.-C. Lin and C.-F.Chen Heterocycles 1995 41 1071. 46 M. Chakrabarty A. Batabyal M. S. Morales-Rios and P. Joseph- Nathan Monatsh. Chem. 1995 126 789. 47 B. Tashkhodzhaev L. V. Molchanov K. K. Turgunov M. K. Makhmudov and K. N. Aripov Khim. Prir. Soedin. 1995 421. 48 K. K. Turgunov B. Tashkhodzhaev L. V. Molchanov M. K. Makhmudov and K. N. Aripov Khim. Prir. Soedin. 1995 426. 49 B. Tashkhodzhaev K. K. Turgunov A. L. D’yakonov G. A. Belova and K. M. Shakhidoyatov Khim. Prir. Soedin. 1995 410. 50 M. V. Telezhanetskaya and A. L. D’yakonov Chem. Nut. Cmpds. Engl. Transl. 1995 31 146. 51 B. Ojo and B. K. Chowdhury Synth. Commun. 1995 25 569. 52 S. P. Marsden K. M. Depew and S. J. Danishefsky J. Am. Chem. Soc. 1994 116 11 143. 53 Y. Takemura M. Ju-ichi M.Omura M. Haruna C. Ito and H. Furukawa Heterocycles 1994 38 1937. 54 Y. Takemura M. Ju-ichi T. Hashimoto Y. Kan S. Takaoka Y. Asakawa M. Omura C. Ito and H. Furukawa Chem. Pharm. Bull. 1994 42 1548. 55 Y. Takemura Y. Matsushita S. Onishi T. Atarashi J. Kunitomo M. Ju-ichi M. Omura C. Ito and H. Furukawa Heterocycles 1995 41 187. 56 Y. Takemura J. Kuwahara N. Nagareya M. Ju-ichi M. Omura I. Kajiura C. Ito and H. Furukawa Heterocycles 1994 39 315. 57 G. D. Potts and W. Jones Actu Crystallogr. Sect. C 1995 51,267. 58 C. Jolivet C. Rivalle and E. Bisagni J. Chem. Soc. Perkin Trans. I 1995 511. 59 Y. A. Geewananda P. Gunawardana and G. A. Cordell Arch. Pharmacal Rex 1995 18 195 (Chem. Abstr. 1995 123 144 334). 60 J. Reisch and A. A. W. Voerste Sci Pharm. 1994 62 255 (Chem. Abstr. 1995 123 187 836). 61 T.-L. Su and T.-C. Chou Chin. Pharm. J. (Taipei) 1994 46 371 (Chem. Abstr. 1995 122 229 849). 20 Natural Product Reports

ISSN:0265-0568    

DOI:10.1039/NP9971400011

出版商:RSC    

年代:1997

数据来源: RSC

摘要:

ISSN 0265-0568 NPRRDF 14 1-1-1-94 (1997) Natural Product Reports A journal of current developments in bioorganic chemistry Volume 14 Indexes CONTENTS ... 111 Preliminary pages for Volume 14 1-1 Subject index 1-47 Index of authors cited ISSN 0265-0568 Coden NPRRDF Natural Product Reports A journal of current developments in bioorganic chemistry Volume 14 1997 The Royal Society of Chemistry Cambridge Natural Product Reports (ISSN 0265-0568) 0 The Royal Society of Chemistry 1998 All Rights Reserved No part of this publication may be reproduced stored in a retrieval system or transmitted in any form or by any means electronic mechanical photographic recording or otherwise without the prior permission of the publishers.Printed in the UK by Henry Ling Ltd at the Dorset Press Dorchester Dorset ISSN 0265-0568 NPRRDF 14 1-1-1-94 (1997) Natural Product Reports A journal of current developments in bioorganic chemistry Volume 14 CONTENTS 1 Brassinosteroids Shozo Fujioka and Akira Sakurai 11 Quinoline quinazoline and acridone alkaloids Joseph P. Michael Reviewing the literature published between July 1994 and June 1995 21 Indolizidine and quinolizidine alkaloids Joseph P. Michael Reviewing the literature published between July 1994 and June 1995 43 Lignans neolignans and related compounds Robert S. Ward Reviewing the literature published between January 1994 and December 1995 75 Cyclopeptide alkaloids Dimitris C. Gournelis Gregory G. Laskaris and Robert Verpoorte Reviewing the literature published between January 1985 and December 1995 83 Recent advances in chemical ecology Jeffrey B.Harborne Reviewing the literature published between July 1992 and December 1995 99 The role of carbohydrates in biologically active natural products Alexander C. Weymouth-Wilson 111 The biosynthesis of C5-CZ5 terpenoid compounds Paul M. Dewick Reviewing the literature published between 1993 and 1995 145 Natural sesquiterpenoids Braulio M. Fraga Reviewing the literature published in 1995 163 Fatty acids fatty acid analogues and their derivatives Marcel S. F. Lie Ken Jie Mohammed Khysar Pasha and M. S. K. Syed-Rahmatullah Reviewing the literature published between 1988 and 1995 191 Diterpenoid and steroidal alkaloids Atta-ur-Rahman and M.Iqbal Choudhary Reviewing the literature between mid-1994and the beginning of 1996 205 Synthesis of amino acids incorporating stable isotopes Nicholas M. Kelly Andrew Sutherland and Christine Willis Reviewing the literature published between 1990 and mid 1996 221 The biosynthesis of the gibberellin plant hormones Jake MacMillan Reviewing the literature published up to September 1996 245 Diterpenoids James R. Hanson Reviewing the literature published in 1995 259 Marine natural products D. John Faulkner Reviewing the literature published in 1995 303 Amaryllidacae alkaloids John R. Lewis Reviewing the literature published in 1995 309 Chemistry and biosynthesis of clavulanic acid and other clavams Keith H.Baggaley Allan Brown and Christopher J. Schofield 335 Biosynthesis of fatty acids and related metabolites Bernard J. Rawlings Reviewing the literature published up to the end of 1994 359 Biosynthesis of plant alkaloids and nitrogenous microbial metabolites Richard B. Herbert Reviewing the literature published in 1995 373 Steroids reactions and partial synthesis James R. Hanson Reviewing the literature published in 1995 387 Phenethylamine and isoquinoline alkaloids Kenneth W. Bentley Reviewing the literature published between July 1995 and June 1996 413 Recent progress in the chemistry of non-monoterpenoid indole alkaloids Masataka Ihara and Keiichiro Fukumoto Reviewing the literature published between July 1995 and June 1996 43 1 Book review Analysis of steroids by L.John Gould and Toshihiro Akihisa (reviewed by James R. Hanson) 432 Corrigendum 433 Natural products derived from unusual variants of the shikimate pathway Heinz G. Floss 453 Secondary metabolites from marine microorganisms bacteria protozoa algae and fungi Francesco Pietra 465 Coumarins Ana Estkvez-Braun and Antonio G. Gonzalez Reviewing the literature published between January 1995 and December 1996 477 Monoterpenoids David H. Grayson Reviewing the literature published in part of 1993 all of 1994 and part of 199.5 523 Biosynthesis of polyketides Bernard J. Rawlings Reviewing the literature published from mid 1993 to the end of 1994 557 Book review Biochemical aspects of marine pharmacology eds. P. Lazarovici M.E. Spira and E. Zlotkin (reviewed by John Mann) 558 Corrigendum 559 Recent progress in the chemistry of the monoterpenoid indole alkaloids J. Edwin Saxton Reviewing the literature published in 1996 591 Isopentenyl diphosphate isomerase a core enzyme in isoprenoid biosynthesis. A review of its biochemistry and function Ana C. Ramos-Valdivia Robert van der Heijden and Robert Verpoorte 605 Quinoline quinazoline and acridone alkaloids Joseph P. Michael Reviewing the literature published between July 1995 and June 1996 619 Indolizidine and quinolizidine alkaloids Joseph P. Michael Reviewing the literature published betweerz July 1995 and June 1996 637 Pyrrole pyrrolidine pyridine piperidine azepine and tropane alkaloids Reviewing the literature published between 1995 and 1996 653 Pyrrolizidine alkaloids J.Richard Liddell Reviewing the literature published in 1995 66 1 Triterpenoids Joseph D. Connolly and Robert A. Hill Reviewing the literature published between July 1995 and June 1996 David O’Hagan 681 Book review Phytochemical diversity. A source of new industrial products eds. S. Wrigley M. Hayes, R. Thomas and E. Chrystal (reviewed by David O’Hagan) The Royal Society of Chemistry Natural Product Reports Editorial Board International Advisory Board Professor T. J. Simpson (Bristol) Chair Dr S. J. Gould (Rahway NJ) Dr S. L. Flitsch (Edinburgh) Professor H. G. Floss (Washington OR) Dr J. R. Hanson (Sussex) Professor L. N. Mander (Canberra) Dr R. B. Herbert (Leeds) Professor K.Mori (Tokyo) Professor G. Hofle (GBF Germany) Professor J. Mann (Reading) Dr D. O’Hagan (Durham) Professor D. J. Robins (Glasgow) Dr C. J. Schofield (Oxford) Professor J. C. Vederas (Edmonton Canada) Dr D. A. Whiting (Nottingham) ~~~~~ Editorial Staff Publishing Editorial Staff Production Dr Sheila R. Buxton Managing Editor Miss Nicola P. Coward Editorial Production Dr Roxane M. Owen Deputy Editor Coordinator Mrs Dawn J. Webb Editorial Secretary Dr Camel M. McNamara Technical Editor Editorial Office The Royal Society of Chemistry Tel +44 (0) 1223 420066 Thomas Graham House Fax +44(0) 1223 420247 Science Park Cambridge E-mail perkin@rsc.org UK CB4 4WF RSC Server http://chemistry.rsc.org/rsc/ Advertisement sales Tel +44(0) 1223 432240.Fax +44 (0) 1223 426017 Information for Authors Natural Product Reports is a bimonthly journal of critical reviews. It aims to foster progress in the study of bioorganic chemistry by providing regular and comprehensive reviews of the relevant literature published during well-defined periods. Topics include the isolation structure biosynthesis biological activity and chemistry of the major groups of natural products -alkaloids terpenoids and steroids aliphatic aromatic and O-heterocyclic compounds. This is augmented by frequent reviews of the wider context of bioorganic chemistry including developments in enzymology nucleic acids genetics chemical ecology primary and secondary metabolism and isolation and analytical techniques which will be of general interest to all workers in the area.Articles in Natural Product Reports are generally commissioned by members of the Editorial Board but the Society is always prepared to consider offers of articles for publication. In such cases a short synopsis rather than the completed article should be submitted to the Managing Editor ar the address given above. Contributors to Volume 14 Atta-ur-Rahman 191 Baggaley Keith H. 309 Bentley Kenneth J. 387 Brown Allan 309 Grayson David H. 477 Hanson James R. 245 373 431 Harborne Jeffrey B. 83 Herbert Richard B. 359 Pasha Mohammed Khyser 163 Pietra-Valdivia Ana C. 591 Rawlings Bernard J. 335 523 Sakurai Akira 1 Choudhary M. Iqbal 191 Connolly Joseph D. 661 Dewick Paul M. 111 EstCvez-Braun Ana 465 Faulkner D. John 259 Floss Heinz G. 433 Fraga Braulio M.145 Fujioka Shozo 1 Fukumoto Keiichiro 413 Hill Robert A. 6 Ihara Masataka 41 3 Kelly Nicholas M. 205 Laskaris Gregory G. 75 Lewis John R. 313 Liddell J. Richard 653 Lie Ken Jie Marcel S. F. 163 MacMillan Jake 22 1 Mann John 557 Saxton J. Edwin 559 Schofield Christopher J. 309 Sutherland Andrew 205 Syed-Rahmatullah M. S. K. 163 van der Heijden Robert 591 Verpoorte Robert 591 Ward Robert S. 43 Weymouth-Wilson Alexander C. 99 Willis Christine 205 Gonzalez Antonio G. 465 Gournelis Dimitris C. 75 Michael Joseph P. 11 21 605 619 O’Hagen David 637 681 Nomenclature It is the policy of The Royal Society of Chemistry to en- courage the use of IUPAC* and IUBMB* Recommendations on nomenclature. Many of the appropriate nomenclature documents are included in the following compilations.Compilations 1 Nomenclature of Organic Chemistry Sections A B C D E F and H 1979 edition a 550-page hardcover volume published in 1979 available from Pergamon Press Oxford. Section F of this volume covers general principles for the naming of natural products. 2 A guide to IUPAC Nomenclature of Organic Compounds (Recommendations 1993) a 182-page softcover volume published in 1993 available from Blackwell Scientific Publications Oxford to be used in conjunction with item 1. 3 Biochemical Nomenclature and Related Documents A Compendium 2nd edition 1992 a 348-page softcover manual published in 1992 by Portland Press Ltd for IUBMB and available from the publisher (59 Portland Place London W1N 3AJ UK). 4 Compendium of Chemical Terminology IUPAC Recommendations a 456-page volume published in 1987 available in hardcover and softcover from Blackwell Scientific Publications Oxford.Specific Recommendations A selection of specific recent recommendations [many of which are included in Biochemical Nomenclature and Related Documents see above] that will be of particular interest to those who investigate bioorganic chemistry or the chemistry occurrence or biosynthesis of natural products includes Extension of Rules A-1.1 and A-2.5 concerning numerical terms used in organic nomenclature (Recommendations 1986) Pure Appl. Chem. 1986 58 1693-1696. [The original versions of these Rules are in Nomenclature of Organic Chemistry 1979 edition see above] Nomenclature of steroids (Recommendations 1989) Eur.J. Biochem. 1989 186 429-458. Nomenclature of tetrapyrroles (Recommendations 1986) Pure Appl. Chem. 1987 59 779-832. Nomenclature and symbols for folic acid and related compounds (Recommendations 1986) Pure Appl. Chem. 1987 59 833-836; Eur. J. Biochem. 1987 168 251-253. Nomenclature of prenols (Recommendations 1986) Pure Appl. Chem. 1987 59 683-689; Eur. J. Biochem. 1987 167 181-184. Nomenclature of retinoids (Recommendations 198 l) Pure Appl. Chem. 1983 55 721-726; Eur. J. Biochem. 1982 129 1-5. Nomenclature of vitamin D (Recommendations 1981) Pure Appl. Chem. 1982 54 1511-1516; Eur. J. Biochem. 1982 124 223-227. Nomenclature of tocopherols and related compounds (Recommendations 1981) Pure Appl.Chem. 1982 54 1507-1510; Eur. J. Biochem. 1982 123 473-475. Recommendations for the presentation of thermodynamic and related data in biology (1985) Eur. J. Biochem. 1985 153 429434. Enzyme Nomenclature (Recommendations 1984) Supplement 1 Corrections and additions Eur. J. Biochem. 1986 157 1-26. Enzyme Nomenclature 1992 (Recommendations of the Nomenclature Committee of the International Union of Biochemistry on the nomenclature and classification of enzyme- catalysed reactions) Academic Press Orlando Florida 1992. Nomenclature for multienzymes (Recommendations 1989) Eur. J. Biochem. 1989 185 485-486. Symbolism and terminology in enzyme kinetics (Recommendations 1981) Eur. J. Biochem. 1982 128 281-291. Symbols for specifying the conformation of polysaccharide chains (Recommendations 1981) Pure Appl.Chem. 1983 55 1269-1272; Eur. J. Biochem. 1983 131 5-7. Polysaccharide nomenclature (Recommendations 1980) Pure Appl. Chem. 1982 54 1523-1526; Eur. J. Biochem. 1982 126 439-441. Abbreviated terminology of oligosaccharide chains (Recommendations 1980) Pure Appl. Chem. 1982 54 1517-1522; Eur. J. Biochem. 1982 126 433-437. Nomenclature of glycoproteins glycopeptides and peptidoglycans (Recommendations 1985) Eur. J. Biochem. 1986 159 1-6. Nomenclature and symbolism for amino acids and peptides (Recommendations 1983) Pure Appl. Chem. 1984 56 595-624; Eur. J. Biochem. 1984 138 9-37 (see also Eur. J. Biochem. 1985 152 1 and the Newsletter 1985 of NC-IUB and JCBN ibid.1985 146 pp. 238 and 239 and the Newsletter 1986 ibid. 1986 154 pp. 485 and 486). Nomenclature for incompletely specified bases in nucleic acid sequences (Recommendations 1984) Eur. J. Biochem. 1985 150 1-5 (see also Eur. J. Biochem. 1986 157 1). Abbreviations and symbols for the description of conformations of polynucleotide chains (Recommendations 1982) Pure Appl. Chem. 1983 55 1273-1280; Eur. J. Biochem. 1983 131 9-15 (see also the Newsletter 1984 of NC-IUB and JCBN Eur. J. Biochem. 1984 138 p. 7). A list of restriction endonucleases and their isoschizomers (updated annually) is given in R. J. Roberts and D. Macelis Nucleic Acids Res. 1991 19 2077-2109. Glossary for chemists of terms used in biotechnology Pure Appl. Chem.1992 64,143. Selection of terms symbols and units related to microbial processes Pure Appl. Chem. 1992 64 1047. Organism Nomenclature Recent codes of nomenclature for organisms include International Code of Nomenclature of Bacteria and Statutes of the International Committee on Systematic Bacteriology (I989 Revision) ed. P. H. A. Sneath V. B. D. Skerman and V. McGowan American Society for Microbiology Washington DC USA 1976. [Appendix 2 of this publication (Approved Lists of Bacterial Names) appeared in Int. J. Syst. Bacteriol. 1989 39.1 International Code of Botanical Nomenclature (1988) ed. W. Greuter H. M. Burdett W. G. Chaloner V. Demoulin R. Grolle D. L. Hawksworth D. H. Nicholson P. C. Silva F. A. Stafleu E. G. Voss and J. McNeill Koeltz Scientific Books Konigstein Germany 1988.International Code of Zoological Nomenclature 3rd edn ed. W. D. L. Ride C. W. Sabrosky G. Bernardi R. V. Melville J. 0. Corliss J. Forest K. H. L. Key and C.W. Wright International Trust for Zoological Nomenclature in association with the British Museum (Natural History) London UK and the California Press Berkeley and Los Angeles USA 1985. * IUPAC International Union of Pure and Applied Chemistry. IUBMB International Union of Biochemistry and Molecular Biology.

ISSN:0265-0568    

DOI:10.1039/NP99714FP015

出版商:RSC    

年代:1997

数据来源: RSC

摘要:

Indolizidine and quinolizidine alkaloids Joseph P. Michael Centre for Molecular Design Department of Chemistry University of the Witwatersrand Wits 2050 South Africa Covering July 1994 to June 1995 Previous review 1995 12 535 1 General reviews 2 Slaframine 3 Hydroxylated indolizidine alkaloids 3.1 Monohydroxyindolizidines and dihydroxyindolizi-dines 3.2 Swainsonine and related compounds 3.3 Castanospermine and related compounds 4 Alkaloids from ants and amphibians 4.1 3,5-Disubstituted indolizidines 4.2 5-Monosubstituted and 5,8-disubstituted indolizidines 4.3 Alkaloids of the pumiliotoxin class 4.4 Cyclopenta[h]quinolizidine alkaloids 5 Polycanthisine 6 Phenanthroindolizidine and phenanthroquinolizidine alkaloids 7 Lythraceae alkaloids and myrtine 8 Alkaloids of the lupinine-cytisine-sparteine-matrine-Ormosia group 8.1 Occurrence detection and analysis 8.2 Chemotaxonomy chemical ecology and biological studies 8.3 Structural and spectroscopic studies 8.4 Synthesis and other chemical studies 9 Petrosin 10 References 1 General reviews The dynamic in vivo activity of alkaloids in ecosystems and the underlying reasons for alkaloid production and accumu- lation have been probed in an important and wide-ranging review in which indolizidine and quinolizidine alkaloids amongst many other classes fall under the spotlight.' The 1 3 4 XI c- 99% lupin quinolizidines are well represented in this review which also features chemoecological studies on indolizidines from ants and frogs and plant metabolites such as swainsonine and castanospermine.An important review describing recent progress in both asymmetric and non-asymmetric synthesis of piperidine and indolizidine alkaloids covers the period January 1990 to June 1993.* Included in this review are selected syntheses of slaframine amphibian and ant indolizidine alkaloids Elaeo-carpus alkaloids indolizomycin and septicine as well as certain quinolizidine alkaloids such as myrtine lupinine and epilupinine and Lythraceae alkaloids. 2 Slaframine Wasserman's use of the vicinal tricarbonyl compound 1 as a building block for pyrroles has been put to good use in a new synthesis of ( f)-slaframine 2 (Scheme l).' Condensation between 1 and amine 3 yielded the 3-hydroxypyrrole 4 the inherent enolic nucleophilicity of which was exploited in alkylative cyclization to form the indolizidine nucleus.Although product 5 was formed as an equal mixture of two separable racemic diastereoisomers reduction of either fol- lowed by hydrogenolysis and decarboxylation yielded the same ketone 6 probably via a common enol intermediate. The pivotal acetoxy alcohol 7 was then transformed in two steps into oxime 8 hydrogenation of which yielded slaframine 2 as the sole product. However when the methanesulfonate of 7 was treated with azide ion the leaving group was displaced with retention of configuration; reduction of equatorial azide 9 then resulted in the formation of 6-epi-slaframine 10.Gmeiner and co-workers have used vicinal tricarbonyls akin to 1 in the synthesis of slaframine isomers. For instance an analogue of amine 3 derived from malic acid was converted by similar methodology to that shown in Scheme 1 into OH 5 v 75% 1 ix x v i-vi ii c--52% RNH HON HO' Bu%le2SiO*' 2 (*)-slafrarnine R = H a 7 6 11 R=Ac 1 xii. xiii 75% 12 13 10 9 Scheme 1 Reugents i CH2C12 Et20 SO2 room temp.; ii PPh, CBr, THF room temp.; iii NaH THF room temp. then separate; iv BF,-Et,O Super-Hydride THF -78 "C; v H (55 psi) 10% Pd-C EtOAc room temp.; vi L-Selectride THF -78 "C; vii Ac,O NEt, DMAP CH,C12 room temp.; viii aq. HF MeCN room temp.; ix (COCI), DMSO NEt, CH,Cl, -78 "C; x NH,OH.HCl py EtOH reflux; xi H (40psi) PtO, EtOH aq.HC1 room temp.; xii mesylation; xiii NaN,; xiv H, Pd-C Michael Indolizidine and quinolizidine alkaloids PhS02 (1 S,6S,8aS)-N-acetylslaframine1 1,4 while an amino alcohol derived from L-aspartic acid was the precursor in syntheses of (+)-8a-epi-slaframine 12 and (+)-1,8a-di-epi-slaframine 13.5 PhS02 OCH20Bn PhSO2 OCH20Bn Livestock foraging on crops contaminated with the fungus Rhizoctonia legurninicola the source of both slaframine and i,ii + swainsoinine develop a disorder known as 'the slobbers'. The involvement of these two alkaloids in slobbers syndrome has 27% (2:1) OH OH 0 0 17 15 iii 84% I iv v 98-1 00% (4840%conversion) vi vii 36% 14 19 Scheme 2 Reagents i 15 BF,-Et,O THF -78 "C added to 16 BuLi (2 equiv.) THF -78 "C to 0 "C; ii TFAA 0 "C; iii BH,.THF THF 0 "C; iv MsCl NEt, K2C03 CH2C12 room temp.; v H (39 psi) Pd(OH), MeOH; vi H (10-20 psi) 10% Pd-C MeOH TFA room temp.; vii 6% Na-Hg MeOH room temp.21 22 \+ -OH --OH L 20 (-)-lentiginosine 0 Scheme 3 Reagents i BnOCOCl NaOH (4~),room temp.; ii BH,.Me,S THF 0 "C to room temp.; iii py-SO, DMSO 0 "C to room temp.; iv Ph,P=CHCO,Et C,H, room temp.; v AD-mix-P Bu'OH-H,O room temp. then separation of acetonides by chroma- tography; vi H (1 atm) 10% Pd-C NaOAc MeOH; vi BH,.Me,S THF room temp. i ii 70% (1:12) or i iii iv 43% (1 0O:O) 0 0 (S)-23 vi vii 59% + 29% been reviewed in a comprehensive article that deals with the known physiological activity of the individual alkaloids and presents a hypothesis for the involvement of multiple agents.6 Continuing investigations on the deliberate administration of slaframine to steers in order to alter salivation and hence perhaps improve digestion and ruminal function (e.g.by raising the ruminal pH) have been reported in three publication^.^^^ 3 Hydroxylated indolizidine alkaloids The use of 2-trialkylsilyloxypyrroles in the enantioselective synthesis of polyhydroxylated pyrrolizidines indolizidines and quinolizidines amongst other compounds has been reviewed.lo 3.1 Monohydroxyindolizidines and dihydroxyindolizidines (+)-(1S,8aS)- 1-Hydroxyindolizidine 14 a putative biosyn-thetic precursor of slaframine 2 has been prepared by a route in which the key step is a stereocontrolled addition reaction between the imine 15 made in six steps from (5')-malic acid and the dianion of sulfone 16." A 2:l mixture of lactams 17 and 18 was formed in 27% yield.These isomers were taken separately through the reaction sequence shown in Scheme 2. After the final desulfonylation step both yielded the same product 14 in greater than 95% optical purity. 8-Hydroxyindolizidine has been prepared as the racemic 8,8a-trans isomer 19,12 and as a mixture of racemic diastereoisomers. The first reported synthesis of ( -)-lentiginosine 20 (Scheme 3) began with (R)-pipecolic acid 21 and introduced the remaining two stereogenic centres by Sharpless asymmet- ric dihydroxylation of intermediate 22 with AD-mix+ l4 The final (lR,2R,8aR) product 20 ([aID-2.6 c 1.0 MeOH) appeared to correlate with natural ( -)-lentiginosine ([aID-3.3 c 0.33 MeOH) thereby supporting previous argument^'^ that the (lS,2S,8aS) absolute configuration assigned to the laevorotatory natural product on biogenetic grounds when it was first isolatedI6 may have been incorrect [cJ ref.18(a)]. For comparison (+)-lentiginosine was pre-pared in a similar fashion from (S)-pipecolic acid. However a very recent publication (to be discussed fully in next year's report) provides evidence that natural lentiginosine is almost certainly the (+)-(1 S,2S,8aS) enantiomer 20 and that the + @*~ 0 14 ---1'I: 54% H OBZ OH viii viii -OBZ -OBz + -OH 98% 100% ent-20 (+)-lentiginosine 0 24 0 Scheme 4 Reagents i K-Selectride (1 M in THF) Et,O -78 to 0 OC; ii H,O (as.JO%) HCO,H 23 OC; iii NBS H,O-THF H,PO, 0 to 23 OC; iv K,CO, MeOH 23 "C; v BH,.THF LiBH, THF 0 "C then aq. HCl 0 to 60 C; vi H,SO (as. l%) acetone (l:l) 70 "C; vii PhCOC1 py DMAP CH,Cl, 23 "C; viii LiAlH, Et,O 0 to 23 "C 22 Natural Product Reports negative rotation originally recorded for the alkaloid may have been due to an impurity." Last year's review highlighted a publication in which compound 23 available as either enantiomer was introduced as a potential precursor for hydroxylated indolizidine alkaloids.18" Several uses for this building block have now been published." Scheme 4 shows conversions of (3-23 into (1S,8a3-1-hydroxyindolizidine 14 (+)-lentiginosine ent-20 and (+)-1,2-di-epi-lentiginosine 24.3.2 Swainsonine and related compounds The occurrence of swainsonine 25 in a higher plant belonging to a family other than the Leguminosae has been established for the first time.20 When grazed by livestock the Australian plant Ipomoea sp. Q6 [aff. calobra] (Weir vine) a member of the Convolvulaceae causes a nervous derangement indicative of a lysosomal storage disease. GC-MS analysis of the trimeth- ylsilylated alkaloid fraction from seeds of the plant revealed the presence of two structurally different principal compo- nents swainsonine and the hydroxylated nortropane alkaloid calystegine B 26. The former made up 0.048% of the mass of dried plant material -far more than the 0.001% known to produce neurological damage in livestock grazing on loco- weeds.Insufficient material was obtained to establish the absolute stereochemistries but the fact that alkaloid extract from the seeds inhibited a-mannosidase J3-glucosidase and a-galactosidase suggested that the enantiomers obtained were the expected ones ( -)-swainsonine and (+)-calystegine. Both alkaloids were also found to be present in seeds of Ipomoea polpha swainsonine at a level of 0.107% of dry mass. OH HN ' CI QH IL & hl QH OH -OH HO V'1.J HO 25 (-)-swainsonine 26 (+)-calystegineB2 Substantial improvement in swainsonine levels from fed- batch fermentations of the fungus Metarhizium anisopliae has been achieved in a complex medium based on oatmeal extract fed intermittently with D-glucose and ( f)-lysine.21 Titres of swainsonine were elevated to 500 mg 1 -after 550 h of fer- mentation a dramatic increase over the previously reported22 18 mg 1-' after 170 h of fermentation [cJ ref.18(a)]. The production of swainsonine by both untransformed and transformed root cultures of Swainsona galegijolia discussed in last year's review,"" has been described again in published conference proceeding^.^^ Included in the same volume is a description of the analysis and identification of swainsonine from Astragalus and Oxytropis species found in Asia and South America and which have been found to cause poisoning in goats and horses.24 The species in which swainsonine has been detected for the first time include A.pehuenches and A. illini from Argentina A. garbancillo and A. junin from Peru A. strictus from Tibet A. variabilis and 0. deflexa from Inner Mongolia and 0.ochrocephala 0.kansuensis 0. caerulea and 0. imbricata from China. A quantitative bioassay for swain- sonine based on the inhibition of jack bean a-mannosidase has shown that the alkaloid is apparently present in the seeds of several Swainsona Astragalus and Oxytropis species notably S. canescens S. galegijolia S. kingii S. procumbens A. boeticus and A. garban~illo.~~ Three syntheses of ( -)-swainsonine have been published during the review period. The anti-diastereoselective (9 1) 'matched' alkylation of epoxy aldehyde 27 with tartrate-modified allylboronate 28 is the central feature in Hunt and Roush's synthesis of ( -)-swainsonine 25 shown in Scheme Michael Indolizidine and quinolizidine alkaloids 5.26 The unusual substituent on silicon favours oxidative replacement of Si by OH with retention of configuration in the transformation of intermediate 29 into diol 30.The formal route developed by Honda et al.,' (Scheme 6) involving radical cyclization of alkynylsilane 31 to 32 as well as Beck- mann rearrangement of oxime 33 to give lactam 34 concluded with the formation of ( -)-swainsonine acetonide 35 which has been synthesized several times in the past.28 Another formal synthesis of ( -)-swainsonine also shown in Scheme 6 began with the kinetic resolution of the furan derivative 36 under Sharpless epoxidation conditions the more reactive enantiomer undergoing conversion into the (2S,6S)-dihydropyridinone 37.29 Sharpless asymmetric dihydroxyla- tion on the subsequent intermediate 38 introduced the remain- ing two stereogenic centres and yielded the (7S,8R)-diol39 and its (7R,8S) isomer in a 1O:l ratio.This formal synthesis terminated with the preparation of benzyloxy acetonide 40 whose conversion into ( -)-swainsonine has been described by Kibayashi and co-~orkers.~' 27 28 30 29 iv v 84% 1 I vi vii ___) Br CHO 65% 25 (-)-swainsonine Scheme 5 Reagents i 48 molecular sieves toluene -78 "C; ii TFA THF 0 to 23 "C; iii KF KHCO, H202 (30%) THF-MeOH 23 "C; iv Me,C(OMe), PPTS CH,C12; v O, CH2CI, -78 "C then PPh,; vi NH,OAc 3 A molecular sieves MeOH reflux then NaBH,CN; vii HCI (6 M) THF The unnatural (+)-enantiomer of swainsonine ent-25 has been synthesized for the first time by Hirama and co-workers from the enantiomerically pure L-glutamic acid derivative 41 .31 Scheme 7 shows the stereochemically significant steps in this synthesis.Base-initiated intramolecular conjugate addition of amide 42 gave anti-lactam 43 as the sole product. Once chain elongation and cyclization had been achieved the bicyclic lactam 44was converted into the cis-diol45 by simple osmyla- tion which occurred preferentially from the (3 face (6.9:1). Interestingly when osmylation was performed in the presence of various chiral ligands the la,2a-diol was favoured. In a curious corollary to this work the isomeric bicyclic lactam 46 underwent preferential dihydroxylation at its a face irrespec- tive of the osmylation conditions.The transformation of the resulting product 47 into ( -)-8,8a-di-epi-swainsonine 48 was straightforward. Other new swainsonine analogues reported during the review period are the five optically active 1,2,6-trihydroxyindolizidines (+)-49 and its enantiomer and ( -)-50 (-)-51 and (-)-52 made by a route involving hetero- Diels-Alder cycloaddition between carbohydrate-derived imines and oxygenated dienes.'2 Compound 49 was a moder- ate inhibitor of Lupinus luteus a-mannosidase (K,=4.75 Im 92% 40% 83% 94% 0 OEE OSiMe2Bu' I 35 Me3SiCrCCH2 OH 0 32 33 34 Ref. 28 ; 31 i &-OH 25 (-)-swainsonine Ref.30 tj 0 36 OH 38 39 40 37 Scheme 6 Reagents i Bu,SnH AIBN C,H, reflux; ii SOCl, 0 "C; iii Ti(OPr'), D-( -)-DIPT Bu'OOH SiO, CaH, CH,Cl, 25 "C; iv OsO (cat.) NMO MeSO,NH, DBQN-CLB acetone-H,O ultrasound 0 .8steps+-.- - .-15% Bu'Me2Si0 C02Me Bu%le2Si0 -i (;:1-'-CO&k NH2 80% NH ii,iii 54% Bu'Me2Si0 Bu'Me2Si0flMeOMe iv-ix ~ NH 41% OH OH 0 0 0 0 41 42 43 44 10 steps j 25% I X 82% (6.9:l) I Bu'Me2Si0 xi xii OH c-OH 71% N H Boc ent-25 (+)-swainsonine 45 + 1a,2aisomer (6.9:l) Bu'Me2Si0 Bu'Me2SiO Bu'Me2Si0 H oH Ho H OH C02Me ___) ___) xvii-xviii xiii-xvi -OH -a-oH 63% 87 /o 32% Boc @0 xo 0 46 47 48 Scheme 7 Reagents i Bu'OK THF -55 "C; ii LiCHBr, THF -90 "C then BuLi -90 "C; iii K2C03 MeOH; iv MsCl NEt, CH,Cl,; v KH THF; vi p-TsOH acetone; vii NaBH, MeOH 0 "C; viii NaH THF CS2 then MeI; ix 180 "C; x OsO (cat.) NMO acetone H,O room temp.; xi TFA THF H,O then Ac20 py CH,Cl,; xii BH3.THF reflux then K2C03 MeOH then HCl (2 M) reflux; xiii Na (10 equiv.) TMSCl (14 equiv.) toluene reflux; xiv K2C03 MeOH; xv LDA PhSeBr THF; xvi H,O, py; xvii 2-methoxypropene CSA CH,CI,; xviii BH,.THF then HCl(1 M) reflux x lop4M) and compound ent-49 inhibited P-glucosidase activity in insect cell^.'^ Swainsonine a known inhibitor of (Ki=1.6 x loF4M).However compound 50 expected on the Golgi mannosidase 11 stimulated in vitro growth of root cul- basis of literature analogies to be a potent a-mannosidase tures of Lupinus albus perhaps by altering the glycosylation inhibitor failed to inhibit mannosidases from jack bean or L.processes that affect cell wall extensibility and hence cell elon- The alkaloid increased the susceptibility of various luteus. The pentahydroxylindolizidine 53 reported in last gati~n.~~ year's review,lSb is a better inhibitor of P-galactosidase than CD4-human cell lines to infection by the LAV-2/B strain swainsonine while its isomer 54 is a potent inhibitor of jack of human immunodeficiency virus type 2 (HIV-2) suggesting bean a-mannosidase but not P-galactosida~e.~~ the existence of an alternative CD4-independent receptor for Swainsonine is now so common a tool for probing the HIV-2.37 structure and function of specific glycosidases and for unrav- Rats treated with the locoweed Astragalus mollissirnus and elling the intricacies of glycoprotein processing that most with swainsonine displayed virtually identical neurophysiolog- recent publications in which the alkaloid is used for these ical responses and suffered very similar vacuolar degeneration purposes no longer merit individual mention in this review.of renal thyroid lymph spleen lung liver and thymus cells. Unusual mannosidase activities found to be inhibited by swain- All swainsonine-induced vacuoles contained mannose-rich Cattle and sheep ingesting the locoweeds sonine include in microsomes of the parasite Trypanosoma oligo~accharides.~~ cruzi a membrane-bound activity not involved in protein-Oxytropis sericea and Astragalus lentiginosus showed high and a-D-mannosidase 11 serum concentrations of swainsonine and decreased serum linked Man,GlcNAc proce~sing,~~ 24 Natural Product Reports a H O OH HO.-& ?H -OH OH 49 ent-49 H ?H HOD y ?H H oHr?H HO..a n -OH -OH -OH 50 51 52 H O .. S -OH HOS-oH HO" HO 53 54 a-mannosidase activity during the treatment but levels re- turned to normal after treatment.39 The results suggest that these values might be used as sensitive indicators of locoweed intoxication in livestock. 3.3 Castanospermine and related compounds No new syntheses of castanospermine 55 have been published during the review period. However diastereoisomers and other structurally modified analogues of this important glycosidase inhibitor continue to be popular synthetic targets. The reaction of substituted allyldiisopinocampheylboranes with pentose derivatives has opened up a new route to castanospermine analogues as illustrated by syntheses of 6,8a-di-epi-castanospermine 56 and 8a-epi-castanospermine 5740.Racemic malic acid was the precursor in syntheses of rac-56 rac-57 rac-1,6-di-epi-castanospermine58 and rac-6-deoxy-8a-epi-castanospermine 59.41During the course of a new synthesis of l-deoxy-8,8a-di-epi-castanospermine60 a compound pre-viously thought to be 1-deoxy-8a-epi-castanospermine 6142 was shown to be 1-deoxy-8-epi-castanospermine 62.43Further structural variations on the castanospermine theme are repre- sented by the 5-hydroxymethylindolizidine 6344and the quino- lizidine analogues ( -)-64 ( -)-65 and ( -)-66 which were made by a similar route to that described for swainsonine analogues 49-52 (Section 3.2).45 When allowed to stand at room temperature in phosphate buffer at pH 7 for a week 6-chloro-6-deoxycastanospermine 67 decomposed to a 5:l mixture of castanospermine-6-phosphate 68 and castanospermine probably via the aziridin- ium ion 69.46 Oxidation of castanospermine with sodium periodate followed by borohydride reduction and acylation yielded the pyrrolidine 70 while oxidation of castanospermine 6-acetate 71 with lead tetraacetate followed by reduction and acylation gave pyrrolidine 72 by a pathway involving a novel degradati~n.~' Recent publications in which castanospermine has been used as a routine probe for glycosidase activity have become too numerous for individual discussion and only a few interesting results are given here.The alkaloid has proved to be an effective competitive inhibitor (Ic5,=2.5 x lop6M) of pig kid- ney trehalase an enzyme involved in sugar transport across the brush border membranes and whose control is thus of thera- peutic interest in the regulation of carbohydrate ab~orption.~' In adult male rats castanospermine inhibited epididymal a-glucosidase (an enzyme that apparently facilitates the stor- age of spermatozoa in the animal); it did not affect motility and kinematics of spermatozoa but seemed to induce infertility during the period of drug admini~tration.~~ The antiinflam- matory effect of castanospermine appears to arise from inhibition of leukocyte passage through the subendothelial basement membrane rather than from prevention of adhesion Michael Indohidine and quinolizidine alkaloids H O'? aOH HO& '? OH H '0 OOH ~ HO.HO HO 55 (+)-castanospermine 56 P-OH 57 a-OH rac-58 rac-59 60 P-OH 62 61 a-OH ""-c-;. HO,' HokH \OH HO HO 63 64 a-OH 66 65 P-OH 67 X=CI 69 68 X = OPO(OH)2 71 X=OAc 73 X = OCO(CH2)2Me 70 72 between leukocytes and endothelial cells or interruption of transmigration events. 50 Antiinflammatory effects have also been observed in murine models where castanospermine inhibited rejection of thyroid allografts and thioglycollate-elicited leukocyte migration into the peritoneal ~avity.~' In studies of heart allograft survival in rats the alkaloid was found to suppress cell-to-cell interactions by interrupting intracellular processing of oligosaccharides and hence 'downregulating' the expression of adhesion molecules (vide infra) on cell membranes.52 Synergism between castano- spermine and the effective but toxic immunosuppressant FK 506 was illustrated both in vitro and in rats with heart allografts thus opening the way for combined therapy that might reduce dose-dependent side effects of both agents.53 The growing importance of 6-butanoylcastanospermine73 (the Merrell Dow drug MDL 28574) which is over thirty times as active as castanospermine in inhibiting the replication of human immunodeficiency virus (HIV) is reflected in the substantial number of papers describing aspects of its biologi- cal activity.It is considerably more effective than the parent compound in inhibiting the glycoprotein-processing enzyme a-glucosidase I in HIV-infected T cells probably because its lipophilic nature facilitates uptake into the cell where it is rapidly hydrolysed to castanospermine itself.54 Furthermore by altering glycoprotein processing MDL 28574 affects the structure of the 'adhesion molecules' responsible for phenom- ena such as antibody-antigen interaction and virus-induced cell fusion (syncytium formation) which is a pivotal feature in the cell-to-cell transmission of HIV infe~tion.~~,~~ Studies performed with various human and murine cell lines in vitro and in live mice have provided evidence for alteration of both virus ligands and host cell adhesion molecules.A synergistic 25 effect of MDL 28574 with other anti-AIDS drugs including AZT has been observed.57 Antiviral effects of MDL 28574 on the herpes simplex types 158and 259 viruses have also been published. In the latter case conclusive evidence was provided for the intracellular conversion of MDL 28574 into castano- spermine. The Merrell Dow group and their associates have also tested no fewer than 35 derivatives of castanospermine (mostly 6-acyl derivatives but also 6,7-diacylcastanospermines and some hydroxymethyl and quinolizidine analogues) as inhibitors of a-glucosidases from porcine kidney and mouse melanoma B,6F1 cells; lipophilic side chains once again appear to facilitate penetration of membranes after which cellular esterases probably release castanospermine as the active metabolite.60 A noteworthy patent describes the combi- nation of castanospermine esters including MDL 28574 with short peptide analogues for treating retroviral infections such as AIDS and the AIDS-related complex.61 4 Alkaloids from ants and amphibians A short colloquium paper by Daly contains a review on the occurrence structure and chemical ecology of poisons isolated from amphibian skins and summarizes the evidence for a dietary source of at least some of these alkaloids.62 An interesting general article in a popular magazine contains full-colour pictures of several neotropical frogs and provides fascinating detail on the traditional uses of frog poisons and the methods of harvesting the skin alkaloids.63 4.1 3,5-Disubstituted indolizidines Two new indolizidine alkaloids ( -)-myrmicarin 237A 74 and (+)-mynnicarin 237B 75 have been isolated from the poison glands of the African ant Myrrnicaria eumenoides (Myrmici- nae).64 The two alkaloids could be separated by column chromatography on neutral alumina but equilibrated to mix- tures of the two compounds within a few hours at ambient temperature.This observation suggested the presence of an easily epimerizable stereogenic centre. Although the gross structures were in due course deduced from NMR spectra on both the separated compounds and the equilibrated mixture the assignment of relative and absolute configurations required total synthesis. When a first synthesis yielded racemic diaster- eoisomers rac-76 and rac-77 having spectroscopic and chroma- tographic properties quite different from those of the alkaloids a second synthesis was required to establish the reI-(3R,5S,9R) and rel-(3R,5R,9R) relative configurations of rac-74 and rac-75 respectively.A third route the enantioselective synthesis illustrated in Scheme 8 used (2S)-2-butyloxirane as the source of chirality and produced pure samples of the four isomers (-)-74 (+)-75 (+)-76 and (-)-77 in better than 98% diastereomeric and enantiomeric excess. The synthetic (3R,5S,9R)-74 and (3R,5R,9R)-75 were shown to be identical with natural ( -)-myrmicarin 237A and (+)-myrmicarin 237B respectively by gas chromatography on a chiral stationary phase.Several syntheses of 3,5-disubs ti tuted indolizidine a1 kaloids reported during the period under review exploit reductive alkylations in which the cyclization of keto pyrrolidines such as 78 is followed by the well-precedented and highly diastere- oselective reduction of iminium ion intermediates such as 79. The iterative reductive alkylation shown in Scheme 9 for instance while unselective in the formation of intermediate 79 showed complete stereochemical control during the reduction of this bicyclic iminium ion intermediate with sodium cyan~borohydride.~~ A 1:l ratio of the ant venom alkaloid ( f)-monomorine I rac-80 and the frog skin alkaloid ( f)-indolizidine 195B rac-81 was formed; the isolated yields after separation were 34% and 27% respectively.In the synthesis shown in Scheme 10 an enantiomerically pure precursor 82 was converted in eleven steps and 8% overall yield into 26 Natural Product Reports 86% OH vi 99% (3:2) J A OH 1 1 ix 86% ix 90% H H 3 74 (-)-myrmicarin 237A (3R,5 R,9S)-76 1 viii x I 27% + 42% 74 xi x 45% + 48% 76 H 75 (+)-myrmicarin 2378 (3R,5s,9S)-77 Scheme 8 Reagents i EtMgBr Et,O -10 to 0°C; ii DMSO (COCI), CH,CI, -50 to -10 "C then NEt, -78 to 20 "C; iii HOCH,CH,OH p-TsOH toluene reflux; iv BuLi THF -15 'C; v (2S)-2-butyloxirane DMPU -50 to 0 "C; vi H (50 atm) 10% Pd-C EtOH; vii p-TsC1 DMAP py -10 to 0 "C; viii chromatography on SiO,; ix HCI (2 M) acetone reflux; x chromatography on neutral alumina (activity grade 111); xi SO, Et,O rt then NEt (+)-indolizidine 195B 81.66 The key step in this case was catalytic hydrogenation over palladium on carbon of the iminium ion intermediate formed after hydrogenolysis of the keto pyrrolidine 83.Compound 81 was accompanied by 84 (88:12 ratio) which is also a known amphibian alkaloid. The synthesis of (3R,5R,8aR)-( -)-indolizidine 195B ent-81 by Lhommet and co-~orkers~~ (Scheme 1 l) used L-proline 85 as -MH the source of chirality and set up the 2,5-trans stereochemistry bo 45% i-iii of the pyrrolidine 86 by Lewis acid-induced reaction of the iminium ion derived from 87 with pent-4-enylcopper. The intramolecular reductive alkylation of keto pyrrolidine 88 performed by hydrogenation over a palladium-barium sulfate catalyst was completely stereoselective.In a slightly different modification of this synthetic route the transformation of 88 into ( -)-indolizidine 223AB 89 and of the cis-disubstituted pyrrolidine 90 into (+)-monomorine I 80 was achieved by hydrogenation over palladium on charcoal.68 This latter paper is a good source of reliable 'H and I3CNMR data for the two alkaloids. 1 78 H H n4H9 79 rac-81 (*)-indolizidine 1958 + H Me fa080 (*)-monomorine I Scheme 9 Reagents i 0, MeOH pH 5 -78 "C; ii NaBH,CN MeOH pH 5 48 molecular sieves room temp. In the synthesis of (+)-monomorine 80 by Munchhof and Meyers reductive alkylation was performed on a keto piperi- dine 91 (Scheme 12).69 This synthesis is interesting for several reasons it demonstrates a new variation on Meyers's use of enantiomerically pure bicyclic oxazolidines in alkaloid synthesis; it presents optimized and potentially general condi- tions for achieving Eschenmoser sulfide contraction in diffi- cult circumstances in this case the conversion of 92 into 93; and it shows a neat use of concomitant hydrogenation and hydrogenolysis of 93 in the creation of the 2,6-cis-disubstituted piperidine 94.The final reductive alkylation of 91 to the target alkaloid 80 carried out by hydrogena- tion over palladium on charcoal as reported previously by Kibayashi and co-~orkers,~~ is a comparatively unimportant feature in the synthesis! Stereoselective hydrogenation of a pyrrole ring is the crucial process in two recent syntheses of monomorine I 80.Jefford et al. who have made a fine art of transforming pyrroles derived from amino acid derivatives such L-glutamic ester 95 into indolizidine alkaloids [cf Section 4.2 below] demonstrated the remarkable stereocontrol that can be Michael Indolizidine and quinolizidine alkaloids 82 OH - c OTIPS 64% OTIPS C4H9 vii viii 78% fl OTIPS C4H9 0 C4H9 83 xi I64% + 9% H H A *% Me Me 'w 81 (+)-indolizidine 195B 84 Scheme 10 Reagents i BuMgBr; ii TPAP NMO; iii DIBAL; iv MeCH(OTIPS)(CH,),MgBr Et,O 0 "C to room temp.; v 500 OC 10-Torr; vi H (1 atm) 5% Pt-C EtOAc; vii MeSO,Cl NEt, CH,Cl, 0°C; viii PhCH,NH, 50°C; ix Bu,NF THF 0°C to room temp.; x DMSO (COCI), NEt, CH,Cl, -78 "C to room temp.; xi H (1 atm) 10% Pd-C MeOH-CO achieved in the catalytic hydrogenation of 96 over palladium on charcoal in acidic ethanol (Scheme 13).71 Product 97 was formed quantitatively and could be converted into (3S,5R,SaR)-(-)-monomorine I ent-80 the unnatural anti- pode of the alkaloid in three simple steps.The novel feature in the synthesis of ( f)-monomorine I by Echavarren and i-iii iv v ~ r...? 69% 63% Bn02CAN Bn02C/N C02H C02Me CH20H 85 87 86 vi vii 72% 1 viii R = Me R 78% C4H9 C4H9 88 ent-81 (-)-indolizidine 80 (+)-monomorine 90 195B R=Me 89 (-)-indolizidine 223AB R=Pr Scheme 11 Reagents i PhCH,OCOCl NaOH 0 "C; ii BF,.Et,O MeOH reflux; iii electrochemical oxidation MeOH -20 "C; iv H,C=CH(CH,),Cu BF,.Et,O Et,O -78 "C; v NaBH, CaCl, THF EtOH -5 "C; vi p-TsC1 NEt,; vii Pr,CuLi -40 "C; viii PdCl,(PhCN), CuCl, O, H,O DMF 70°C; ix H, Pd-BaSO, MeOH; x H, 10% Pd-C MeOH 27 i ii Ill C02Me -80% 60-80% pc6 S Me C02Me 94 93 iv-viiii 75% 0 I Me 91 Me xi 170% H Me iL 80 (+)-monomorine I Scheme 12 Reagents i BrCH,CO,Me (10 equiv.) CHCI, room temp.; ii P(OMe) (4 equiv.) NEt (10 equiv.) CHCI, reflux 2-3 d; iii H2 (3 atm) Pd(OH),-C; iv BnOCOCl NaOH; v hydrolysis; vi (COCI),; vii CH,N, Et,O; viii Ago EtOH; ix HN(Me)OMe; x BuMgBr; xi H, 5% Pd-C co-~orkers~~ the palladium-mediated coupling of the was acid chloride derived from 98 with (E)-vinylstannane 99 to form the 1'4-diketone 100 subsequently used in a modified Paal-Knorr pyrrole synthesis to give 101 (Scheme 14).Cata- lytic hydrogenation over rhodium on charcoal yields a 2:2:1 mixture of ( f)-monomorine I rac-80 and the two diaster- eomers rac-102 and rac-84 both of which are known skin alkaloids of dendrobatid frogs. Condensation between a trimethylsilyl enol ether and a cyclic iminium ion is the key event in the synthesis of (-)-indolizidine 223AB 89 by Pilli et al. (Scheme 15).7' Using (9-( -)-pyroglutamic acid as the chiral educt for 2-ethoxypyrrolidine 103 the iminium ion precursor these workers showed that reaction with the trimethylsilyl enol ether prepared in situ from hept-3-en-2-one yielded in one pot a 2:3 mixture of indolizidinones 104 and 105. Equilibra-tion with base swung the ratio in favour of isomer 104 which was converted via its tosylhydrazone into the target alkaloid.The synthesis of ( f)-indolizidine 223AB illustrated in Scheme 16 involved successive stereocontrolled additions of Grignard reagents to no fewer than three disguised imi- nium ion intermediates formed in situ from a-cyanoamines 106 107 and Thus 107 was the precursor of the cis-2,6-disubstituted piperidine 109 (7 1 % yield) which was accompanied by only 8% of its trans isomer; while treating the 3-cyanoindolizidine 108 with butylmagnesium bromide yielded racemic indolizidine 223AB (rac-89) in 60% yield together with the epimer 110 (18%)' which is itself a known alkaloid from a bufonid toad [cJ ref. 18(c)]. 4.2 5-Monosubstituted and 5,ti-disubstituted indolizidines Jefford and Wang's previously published of the frog skin alkaloid ( -)-indolizidine 209D 111 via a pyrrole intermediate derived from L-aspartic acid has been recapitu- lated in a conference paper.76 The new approach to ( -)-indolizidine 209D shown in Scheme 17 showcases a base-initiated aza-[2,3]-Wittig rearrangement of vinylaziridine 112 to the unsaturated cis-2,6-disubstituted piperidine 113 28 Natural Product Reports Eto2c> i 62% Eto2cLN) NH3+ CI- C02Et C02Et 95 ii 68% 1 f Eto2cLq 81Yo C02Et C4H9 iv I96% > 99% ee 0 kV 100% ___) r1.3 C02Et c4H9 C02Et C4H9 96 97 vi 100% i vii viii 76% Me CH20H C4H9 'w ent-80 (-)-monomorine I Scheme 13 Reugents i 2,5-dimethoxytetrahydrofuran,H,O 80 "C; ii PrCOCl(5 equiv.) toluene reflux; iii NaBH,CN ZnI, ClCH,CH,Cl 50°C; iv BBr, CH,Cl, 25°C; v H (55psi) Pd-C EtOH-H,SO (97:3); vi LiAlH, THF; vii SOCl reflux; viii Bu,SnH AIBN toluene.reflux Me 0 Me 98 0 101 100 rac84 rac-102 rac-80 (*)-monomorine I Scheme 14 Reugents i RuCl (cat.) NaIO,; ii H,O heat; iii SOCl,; iv stannane 99 Pd(PPh,), dioxane 100 'C; v Cd AcOH-DMF (1 :l) 23 "C; vi H (1 atm) Rh-C EtOH 25 "C which possesses the correct relative and absolute stereochem- istry required for the target alkaloid lll.77Also shown in this Scheme are key steps in another synthesis of (-)-indolizidine 209D from the previously mentioned unsaturated 103 (2:3) vi vii 70% 89 (-)-indolizidine 223AB 104 105 t I V 64% + 30% Scheme 15 Rrugents i Pr,Cu(CN)Li, THF -40 "C to room temp.; ii LDA THF -78"C then (Boc),O THF -78 "C to room temp.; iii NaBH, EtOH -23"C then HC1 EtOH; iv 2-trimethylsilyloxyhepta-1,3-diene(made in situ) TMSOTf CH,Cl, -78 to 25 "C; v NH,OH MeOH room temp.; vi p-TsNHNH, EtOH room temp.; vii NaBH, EtOH 0 "C to reflux CN 106 f 107 iii 71Yo+ 8% trans H 1 108 109 110 rac-89 (*)-indolizidine 223AB Scheme 16 Reagents i PrMgBr THF room temp.; ii electrolysis Pt electrode 3.50 V KCN MeOH room temp.; iii 3-oxopropylmagnesium bromide propylene acetal THF 0 "C; iv HOCH,CH,OH HCl; v H (50 psi) Pd(OH),-C EtOH room temp.; vi KCN HCI (1 M) MeOH; vii BuMgBr indolizidinone 23 (see Section 3.1) this time as the (R) enantiomer.l9 The related alkaloid ( -)-indolizidine 167B 114 has been synthesized by means of methodology similar to that described in Section 4.1 for ( -)-indolizine 223AB (see Scheme 11).68 The recent synthesis of 5-cyanoindolizidine 1 1578 also repre- sents a formal synthesis of ( f)-indolizidines 167B and 209D since this compound featured in a previous synthesis by Polniaszek and Belm~nt.~~ Similarly studies culminating in the synthesis of 5-methoxycarbonylindolizidine 116*' and 5-methoxycarbonylmethylindolizidine 11781pave the way for Michael Indolizidine and quinolizidine alkaloids i-iii 87% C6H13 C6H13 iv-vii 49% I c- 78% 98% I C6H13 C6H13 CGH13 vi xi 50%i 113 U 112 H C6H13 \/\r\ 0 11 1 (-)-indolizidine 209D (R)-23 Scheme 17 Reagents i NaN, NH,C1 MeOCH,CH,OH-H,O; ii Bu'Me,SiCl CH,Cl, NEt, DMAP; iii Ph,P toluene reflux; iv BrCH,CO,Bu' K,CO, 18-crown-6 THF; v Bu,NF THF; vi DMSO (COCI), NEt, CH,Cl, -78 "C; vii Ph,P=CH, THF; viii LDA THF -78 "C; ix H, 5% Pd-C EtOH; x LiAlH, THF 0 "C to room temp.; xi Ph,P=CHCO,Et; xii H (4 psi) 5% Pd-C EtOH; xiii Me,Al C,H,; xiv LiAlH, THF reflux; xv H, PtO, EtOAc; xvi C,H,,Li CeCl, THF -78 to -30 "C; xvii NaBH,CN MeOH HC1 new approaches to the 5-alkylindolizidine alkaloids.The former publication provides valuable insights into the choice of conditions for chemoselective reduction of pyrrole-based precursors for indolizidines. i./ CN C02 Me \C02Me 114 (-)-indolizidine 1678 115 116 117 The only 5,8-dialkylindolizidine alkaloid to have been syn- thesized in the period covered by this review is (-)-indolizidine 207A 118 (Scheme 1 8).82 Commencing with gera- niolll9 Taber and co-workers exploited Sharpless asymmetric epoxidation followed by diastereoselective epoxide cleavage to form diol 120 in which the desired stereochemistry of the target alkaloid is latent.Intramolecular dipolar cycloaddition of azido diene 121 followed by reduction with diisobutyl- aluminium hydride provided the key to subsequent stereocon- trol; the all-equatorially trisubstituted piperidine 122 was isolated free of isomers in 63% yield. The synthesis was completed conventionally as illustrated. 4.3 Alkaloids of the pumiliotoxin class Skin extracts of the Ecuadoran dendrobatid frog Epipedobates tricolor have yielded several alkaloids of the pumiliotoxin and allopumiliotoxin classes including pumiliotoxins 237A 123 251D 124 and 307A 125 and allopumiliotoxins 267A 126 323B 127 341A and 357 (structures unknown) as well as indolizidine 203A 128 quinolizidines 217A 129 231A 130 and 23 1B 131 and the highly topical chlorinated tropane-like alkaloid epibatidine 132.83The extracts have also yielded a trace alkaloid deoxypumiliotoxin 25 1 H 133 belonging to a hitherto unknown pumiliotoxin subclass.This compound was characterized by MS IR and NMR analysis and its relative 29 Me R, p 9 Me 119 120 pumiliotoxins v "il57% 123 237A R = MeCH2 124 2510 R = Me(CH2)* vii-ix 125 307A R = 4 p\ OH OH OH R*Me Me allopumiliotoxins 126 267A R=Me(CH2)2 127 3238 R = OH 134 339A R = * OH CH2R' I quinolizidines 121 xii xiii 63% \/\// w 122 118 (-)-indolizidine 207A Scheme 18 Reagents i Sharpless asymmetric epoxidation; ii NaBH,CN BF,.Et,O; iii p-TsC1 CH2C1, NaOH (aq.50%) 0 "C to room temp.; iv H,C=CHCH,MgCI THF 0°C to room temp.; v MsCl NEt, Et 0 0 "C; vi NaN, HMPA 40 "C; vii MCPBA CH,CI, -10 'Cf viii 03,MeOH Sudan 111 indicator -78 "C then NaBH, room temp.; ix HCIO (aq. 5%) THF; x NaI0,-SiO, CH,CI,; xi H2C =CH(CH,),CH =PPh, THF -78 "C to room temp.; xii 1,2-C12C6H4 160 "C; xiii DIBAL CH,CI2 -65 to 0 "C then NaF; xiv PPh, NEt, CCI, MeCN room temp. stereostructure was deduced from Bohlmann bands in the IR spectrum and from coupling constants and NOE effects in the NMR spectrum.The 2 configuration of the alkylidene side chain could not be determined unambiguously but was inferred by analogy with the known pumiliotoxins. Kibayashi's approach to the synthesis of (+)-allopumiliotoxin 267A 126 and (+)-allopumiliotoxin 339A 134 highlighted in previous reviews in these pages'8d3' has been reprised in published conference proceeding^.^^ A new route27 to indolizidinone 135 used a cyclization similar to that outlined for compound 44 in Scheme 7 (Section 3.2) thereby completing a formal synthesisg5 of (+)-pumiliotoxin 251D 124. Pumiliotoxin 251D and 13 synthetic isomers in which the configuration at C-8 and C-2' was varied or in which the side chain was modified have been prepared86 by simple variations to a route described by Overman and Sharp in 1988.87 Testing these compounds for toxicity towards the cotton pest Heliothis virescens (the tobacco budworm) has revealed that a substitu- ent having the (R)absolute configuration at C-2' in the side chain is critical; computational studies suggested that this substituent may control the active conformation of the side chain.The natural product was found to be the most active neurotoxin in the group causing convulsions in 50% of larvae at a concentration of 0.01 pg per larva and having an LD, of 0.15 pg per larva. This appears to be the first study of the toxicity of pumiliotoxins towards insects. 4.4 Cyclopenta(b]quinolizidine alkaloids This relatively recently discovered class of amphibian alka- loids [see ref.18(f)] has now succumbed to total synthesis at the hands of Taber and You who achieved the convergent enantioselective synthesis of alkaloid 251F 136 shown in part in Scheme 19.88 The principles invoked in the synthesis of the enantiomerically pure 2,5-trans-disubstituted piperidine 137 30 Natural Product Reports &/ -128 indolizidine 203A 129 217A R' = H; R2 = CH*CH=CHC=CH 130 231A R1 = Me; R2= CH2CH=CHC~CH 131 231B R1 = H; R2= hexenyl Me 0 132 epibatidine 133 deoxypumiliotoxin 251H 135 are similar to those described in their synthesis of indolizi- dine 207A (Scheme 18 Section 4.2). The other enantiomeri- cally pure building block was the highly substituted cyclopentane 138 formed from 6-methylhept-5-en-2-one in several steps that included asymmetric hydrogenation of a P-keto ester over a Ru-BINAP catalyst.Once 137 had been alkylated with 138 it was necessary to activate the OH group of the coupled product 139 in such a way that the ester enolate could be generated before competing azetidine formation interfered. This was achieved via the unstable benzenesulfonate ester of 139 which cyclized to 140 on treatment with lithium bis(trimethylsily1)amide at -78 "C. Most gratifyingly the ester group in the product was found to have the correct configuration for the target alkaloid. Defunctionalization of the ester was accomplished somewhat unusually by reduction to the alcohol followed by conver- sion into a sulfide and hydrogenolysis with sodium in ammo- nia While the absolute configuration of natural 251F remains unknown this synthesis has provided confirmation of its relative stereostructure.5 Polycanthisine Astragalus polycanthus the source of several structurally diverse indolizidine alkaloids [see ref. 18(g)] has yielded another surprising new metabolite (+)-polycanthi~ine.~~ Comprehensive spectrosopic data were used in formulating the structure illustrated in 141 the skeleton of which is unprecedented amongst naturally occurring indolizidines. The most noteworthy feature well supported by spectro- scopic evidence is the existence of the substituent at C-6 in a free enolic form stabilized by strong intramolecular hydrogen bonding with nitrogen.This enol resisted acetylation but formed a trimethylsilyl derivative that gave essentially the same mass spectral fragmentation pattern as the parent alkaloid. The absolute configuration of polycanthisine remains undetermined. vii-ix I68% + cis isomer (5.51) 137 X 4 56% BnO \ 139 TsO OH 138 C02Et 140 136 alkaloid 251F Scheme 19 Reagmrs i Sharpless asymmetric epoxidation; ii NaBH,CN BF,.Et,O; iii NaI0,-SO, CH,Cl, room temp.; iv NaBH, MeOH 0 "C; v p-TsC1 py CH,Cl, room temp.; vi NaN, DMF 60 "C; vii 0, CH,Cl, -75 "C then PPh, -75 "C to room temp.; viii EtO,CCH,PO(OEt),-NaHMDS THF 0 "C to room temp; ix PPh, H,O -60°C to room temp.; x Bu,NI K,CO, toluene reflux; xi PhSO,Cl py CH,Cl, room temp.; xii LiHMDS THF -78 "C to room temp.; xiii LiAlH, THF 50 "C; xiv (PhS), PPh, (CH,OMe), reflux; xv Na NH, EtOH-THF -78 "C to ambient temperature 6 Phenanthroindolizidine and phenanthroquinolizidine alkaloids The leaves of Tylophora tanakae a previously unexplored species from the Japanese Ryukyu Islands has been shown to contain two well-known phenanthroindolizidines (+)-isotylocrebrine 142 and ( -)-tylophorine 143 along with eight new compounds whose structures were determined with the aid of FAB-MS and UV IR and NMR spectroscopie~.~~ The new compounds are (+)-3-demethylisotylocrebrine 144 (+)-3-demethyl-14a-hydroxyisotylocrebrine 145 ( -)-7-demethyltylophorine 146 and (+)-6-demethyltylocrebrine 147; and four new N-oxides (+)-isotylocrebrine N-oxide 148 (+)-14a-hydroxyisotylocrebrine N-oxide 149 (+)-3-demethyl-1411-hydroxyisotylocrebrine N-oxide 150 and (+)-tylophorinine N-oxide 151.The structure of ( -)-146 was confirmed by its conversion into tylophorine 143 on treat- ment with diazomethane. The (13aS) absolute configurations of all the dextrorotatory alkaloids were inferred from the presence of a positive Cotton effect in their CD curves which correlates with a similar effect in synthetic (+)-(13aS)-tylophorine ent-143. Efficient HPLC-UV and HPLC-MS analysis of extracts of the above-ground parts of Cynanchurn vincetoxicum has revealed the presence of four previously detected [cJ ref. 18(g)] alkaloids tylophorine 143 antofine 152 6-0-desmethylantofine 153 and vincetene 154.91 Over twenty other minor alkaloids were also detected and partially char- acterized according to their UV and MS behaviour.About Michael Indolizidine and quinolizidine alkaloids p 0-H OMe 141 PolYcanthisine 142 (+)-isotylocrebrine R' = Me; R2 = H 144 R' = R2= H 145 R' = H; R2 =OH OMe OMe R2 143 (-)-tylophorine R1 = Me; R2 = OMe 147 146 R1 =Me; R2=OH 152 antofine R' = Me; R2 = H 153 R' = R2 = H (?Me OMe 148 R1 =Me; R2 =OMe; R3= H 154 vincetene 149 R1 = Me; R2 = OMe; R3 = OH 150 R' = H; R2 =OMe; R3=OH 151 R1 = Me; R* = H; R3 = OH half appeared to be phenanthroindolizidines one was tenta- tively identified as a naphthoindolizidine and the rest eluded identification altogether.An unusual new route to ( f)-tylophorine rac-143 commenced with oxidative dimerization of the dianion of homoveratric acid 155 followed by esterification and oxi- dative aromatic coupling with vanadium oxyfluoride to yield the phenanthrene diester 156 (Scheme 20).92 A further six steps were required to elaborate the azido chloride 157 which underwent intramolecular dipolar cycloaddition and subsequent alkylative ring closure on heating to give the iminium ion intermediate 158. Reduction with sodium boro- hydride in situ produced the target alkaloid 143 in an overall yield of 4.7% from homoveratric acid. The proline-derived hydrazine 159 has been used as a chiral auxiliary in Kibayashi and co-workers' enantioselective synthesis of (R)-(-)-cryptopleurine 160 shown in Scheme 2 1.93 Key steps included Lewis acid-catalysed condensation between the acyliminium ion derived from lactam 161 and silyl enol ether 162; reduction of the product 163 which in a one-pot sequence also removed the auxiliary to yield pip- eridine 164 as a mixture of diastereomers; intramolecular aldol condensation in which the keto amide 165 was con- verted into quinolizidinone 166; and the construction of the phenanthrene nucleus of oxocryptopleurine 167 either by photocyclization (54% yield) or intramolecular radical cyclization (87%) of 166.The homochiral alkaloid itself was obtained by hydride reduction of 167. OMe MeO& / C02H 25% Me0sco2Me i-iv I \ C02Me 155 MeOv OMe 156 v-xi 23% 1 7 I OMe xii -Me0 I OMe L 158 157 xiii 82% 1 OMe OMe rac-143 (*)-tylophorine Scheme 20 Reagents i LDA (2 equiv.) THF -78 "C to room temp.; ii I (0.5 equiv.) -78 "C to room temp.; iii CH2N2 EtOH; iv VOF (4.4 equiv.) TFA TFAA CH,Cl, EtOAc 0 "C;v LiAlH, THF 0 "C to room temp.; vi NaH THF then Bu'Me,SiCl; vii PCC on Celite NaOAc CH,Cl,; viii Ph,P=CH(CH,),Cl THF -78 "C to room temp.; ix NaN (3.5 equiv.) NaI (0.1 equiv.) DMSO-Me,CO (l:l) 40°C; x Bu,NF THF 0°C to room temp.; xi MsCl 2,6-lutidine LiCl DMF 0 "C; xii C,D, 130 "C; xiii NaBH, MeOH 0 "C to room temp.7 Lythraceae alkaloids and myrtine In vitro incorporation studies on Heimia salicifolia with labelled lysine phenylalanine and p-coumaric acid have shown that the three major classes of Lythraceae alkaloids (phenyl- quinolizidinols phenylquinolizidinyl p-coumarates and bi-phenylquinolizidine lactones) are formed from different precursor pools but cis- and trans-fused alkaloids within each class originate from a common metabolic The synthesis of ( f)-myrtine 168 ( f)-epimyrtine 169 and ( f)-lasubine I1 170 by Pilli and co-workers previously reported as a communicationg5 [see ref.18(h)] has now been published with full experimental detail^.^' The construction of the quinolizidine system uses principles similar to those illustrated in Scheme 15 (Section 4.2). 8 Alkaloids of the lupinine-cytisine-sparteine-matrine-Ormosia group The first volume of a new annual publication devoted to fundamental studies on leguminous plants contains papers dealing with methods of lupin alkaloid analysis.96 The first paper in the new volume presents an overview of the 32 Natural Product Reports O-$/\ Meo* I I I OBn OBn OBn 159 161 OMe I 162 + ?Me OMe MeoaOH 164 OBn 163 vii viii 42% from 163 OMe OMe 0 I66 x or xi 54% or 87% 1 ?Me Meek xij 55% L167 = O 160 (R)-(-)-cryptopleurine X = 2 H Scheme 21 Reagents i glutaric anhydride CH,Cl, room temp.then Ac,O NaOAc (cat.) reflux; ii LiEt,BH THF -78 "C; iii MeOH PPTS (cat.) room temp.; iv BF,.Et,O CH,Cl, room temp.; v BH,-THF THF reflux; vi NaOH (lo%) reflux; vii p-MeOC,H,CH,COCl NaOH (5%) CH,Cl, 0 "C to room temp. then K2C03 MeOH-H,O reflux; viii PDC CH,Cl, 4 8 molecular sieves room temp.; ix KOH EtOH reflux; x h v (high pressure Hg lamp) NEt, dioxane; xi Bu,SnH AIBN C,H, reflux; xii LiAlH, THF reflux Me0Q OMe 168 myrtine R1 =Me; R2 = H 170 lasubine I1 169 epimyrtine R1 = H; R2 = Me occurrence structure biogenesis bioactivity and biotoxicity of lupin alka10ids.~~ Other relevant papers will be described in the appropriate sections below.Progress on the isolation characterization biosynthesis synthesis and biotechnology of lupin alkaloids during the period 1985-1 993 has been comprehensively reviewed by Ohmiya Saito and Murakoshi in the latest volume of the Academic Press monograph The Alkaloids.'' Saito and Murakoshi have also summarized the occurrence and struc- tural characteristics of lupin alkaloids discovered during their own recent researches in a short review that includes work with plant tissue cultures and isolated enzymes chemotaxonomy and pharmacological ~ignificance.'~ The biosynthesis of quino- lizidine and pyrrolizidine alkaloids forms the focus of an extensive survey by Robins."' 8.1 Occurrence detection and analysis The three new lupin alkaloids reported during the period under review are listed in Table 1 together with known alkaloids isolated from or detected in new plant sources.IoI-'I3 Unspecified alkaloids have also been detected in the previously unexplored Argentinian species Lupinus bracteatus' l4 but not in L.paraguariensis.I I5 A report on the alkaloidal constituents of Oxytropis ochrocephala previously published in the Chinese literatureIt6 [see ref.18(i)] has now appeared in a more accessible journal.' l7 An efficient method for extracting alka- loids from the seeds of Lupinus albus and L. angustifolius without hydrolysing the lactam group of alkaloids such as lupanine 171 has been devised."' Chemical biochemical and spectroscopic methods for the qualitative and quantitative analysis of lupin alkaloids have been critically reviewed."' On the basis of alkaloid ratios found in seeds of a variety of lupin plants a theoretical formula has been devised for extrapolating total alkaloid content in Lupinus polypyllus from a determination of the content of a single alkaloidal component. '' A multi-variate analysis of chromatographic data reported for 87 quinolizidine alkaloids in 40 publications has been per-formed in order to establish the optimal choice of con-ditions for achieving separation by planar chromatographic techniques."') 8.2 Chemotaxonomy chemical ecology and biological studies A study that justifiably claims to be 'the most comprehensive alkaloid survey of lupins which exists so far' has documented the occurrence of ca. 100 quinolizidine piperidine and dipipe- ridine alkaloids in 56 species (embracing 90 subspecies and chemotypes) of the genus Lupinus.'2* Capillary GLC and GLC-MS were used to determine the alkaloid profiles in all known Old World lupins as well as 6 taxa from South America and 36 taxa from North America. Tetracyclic quinolizidine alkaloids with the lupanine 171 sparteine 172 and hydroxy- lupanine 173 skeletons were found in virtually all lupins.Bicyclic alkaloids of the lupinine 174 class occurred mainly in Old World species as did alkaloids of the multiflorine 175 group. This finding was supported by genetic evidence'22 for a close relationship between and probably a common ancestry for lupins of the lupinine and multiflorine complexes. 10-Oxosparteines such as aphylline 176 were characteristic of North American lupins while a-pyridones such as cytisine 177 and anagyrine 178 were rare in all lupins. Large intraspecific variations in alkaloid profiles were found for North American species. Genetic differences have been invoked to rationalize the distinct geographical variation in the alkaloid profiles of Lupi-nus argenteus collected from seven different sites in western Colorado.' lo The alkaloid profiles indicated five different chemotypes of the plant with further differences between alka- loid content in leaf and seed being noted for each chemotype.The most remarkable difference between the chemotypes re- lates to the stereochemistry at C-11; two chemotypes are rich in Michael Indolizidine and quinolizidine alkaloids 0 X 171 lupanine R = H 172 (-)-sparteine X = H,H 173 R=OH 176 aphylline X = 0 184 cineverine R = OCOC6H3-3,4-(OMe)2 174 (-)-lupinhe 175 rnultiflorine 0 0 177 cytisine R = H 178 (-)-anagyrine P-H 186 rhornbifoline R = (CH2)2CH=CH2 179 (-)-thermopsine a-H H 0 182 P-isosparteine 183 5,6-dehydrolupanine 185 retarnine 187 (-)-angustifoline '1 1S isomers' such as sparteine lupanine and anagyrine while three are rich in '1IR isomers' such as thermopsine 179 and a-isolupanine 180.The alkaloid patterns of the wild plants persisted in plants grown from seed under greenhouse condi- tions reinforcing the notion of a genetic basis for the variation. The authors speculate that differences in the alkaloid content of the chemotypes and between seed and leaf may reflect natural selection arising from an allelochemical response to feeding by specialist herbivores. The seeds of 49 genotypes of white lupin (Lupinus albus) from different countries and locations have been analysed for their alkaloid content by TLC and GC-MS.123 This study showed a positive correlation between high alkaloid content and 'bitter' plant varieties; 'sweet' varieties important as ani- mal feeds had alkaloid levels within the safe limit of toxicity (0.04?&0.05%) for animal and human consumption.The principal alkaloid in the bitter varieties was lupanine and other significant components included albine 181 13-hydroxylupanine a-isolupanine and multiflorine. High levels of quinolizidine alkaloids in bitter varieties and cultivars of L. albus appear to be a dominant genetic character.'24 The alkaloid content of L. albus and L. luteus seeds the latter containing lupinine lupanine and sparteine did not change appreciably after germination for up to 96 h.'25 Table 1 Isolation and detection of alkaloids of the lupinine-cytisine-sparteine-matrine-Ormosia groupa ~~~ ~ Species Alkaloid Ref.Ammopiptanthus mongolicus ( f)-Homoormosanine Gamine) 101 ( -)-Homopiptanthine ( f)-3 P-Hydroxylupanine a-Isolupanine 180 17-Oxolupanine 190 17-Oxosparteine Anagyrus foetida (+)-5,6-Dehydrolupanine 183 102 ( -)-Rhombifoline 186 Bowdichia virgilioides ( -)-Podopetaline 103 Chamaecytisus hirsutus Anagyrine 178 104 Dehydrolupanine (position uncertain) Dehydrosparteine (position uncertain) Hydroxyoxosparteine (position uncertain) a-Isolupanine 17-Oxolupanine Cytisus praecox Dehydrosparteines (position uncertain four isomers) 104 a-Isosparteine 225 Lupanine 171 17-Oxosparteine Sparteine 172 Genista aucheri Cytisine 177 105 1Oa-Hydroxymethylsparteine N-Methylcytisine Retamine 185 Genista carinalis Baptifoline 198 105 Lupanine Sparteine Lupinus albus (=L.termis) (+)-15P-Hydroxy-17-oxolupanineb 188 106 ( -)-13a-Hydroxysparteine 107 17-Oxolupanine 106 ( -)-Termineh 191 107 (+)-Tetrahydrorhombifoline 189 106 Lupinus albus cv. BAC 17-Oxolupanine 108 1 1,12-Seco- 12,13-didehydromultiflorine 196 Sparteine Tetrah ydrorhombifoline Lupinus angustifolius cv. Mirela Angustifoline 187 108 5,6-Dehydrolupanine 13-Hydroxylupanine 173 Lupanine Oxolupanine (unspecified) Lupinus arcticus subsp. subalpinus Anagyrine 109 5,6-Dehydrolupanine P-Isosparteine 182 Lupanine Multiflorine 175 Sparteine Lupinus argenteus Aph yllidine 110 Argyrolobine 11,12-Dehydrosparteine 3-H ydroxylupanine Hydroxysparteine (position uncertain) a-Iso-5,6-dehydrolupanine a-Isosparteine Lupinus hirsutus ( -)-(3-Methoxy-4-a-~-rhamnosyloxycinnamoyl)epilupinine~ 111 192 Lupinus polyphyllus var.polyphyllus Anagyrine 109 5,6-Dehydrolupanine P-Isosparteine Lupanine Sparteine Oxytropis kansuensis Anagyrine 112 Sparteine Thermopsine 179 Petteria ramentacea Dioxosparteine (position uncertain) 104 17-Oxolupanine Sophora vicifolia Matrine 113 Matrine N-oxide Sophoramine Sophoridine Spartium junceum Dehydrosparteine (position uncertain) 104 Dioxosparteine (position uncertain) "Only new alkaloids and new records for a given species are listed. bNew alkaloids. Structures of most known alkaloids may be found in previous reviews in this series.34 Natural Product Reports The alkaloidal components of two species of Lupinus found in central British Columbia have been analysed by capillary GLC and identified by GC-MS.Io9 The most interesting find- ing of this research was that while L. arcticus was rich in P-isosparteine 182 multiflorine and the acutely toxic sparteine and L. polyphyllus in lupanine 5,6-dehydrolupanine 183 and the teratogenic alkaloid anagyrine there was an intergrading of alkaloid content in the contact zone in which the two species overlapped. The risk of increased toxicity towards livestock in the ranges in which the species overlap thus appears to be substantial. A comparative study on the alkaloids found in eleven species of Genista native to Turkey has been published.Io5 Greinwald et al.have uncovered further evidence for a chemical di- chotomy amongst the alkaloidal constituents of section Spar-tioides of the genus Genista'26 [see ref. lS(j)]. An investigation of most known members of this section revealed that four species (G. cinerea G. majorica G. ramosissima G. sericea) contained 13-hydroxylupanine and several of its esters -nota-bly the rare alkaloid cineverine 184 -as principal constituents while a further nine species (G. albida G. cinerascens G. florida G. obtusiramea G. pilosa G. pseudopilosa G. subcapitata G. teretifolia G. villarsii) preferen tially produced a-pyridone alka- loids such as cytisine N-methylcytisine and anagyrine.Reta- mine 185 previously claimed127 to be a marker alkaloid for the genus was not detected perhaps because it was incorrectly identified in the earlier work. The authors make the interesting observation that the dichotomous distribution of alkaloids seems to be correlated with soil properties ester alkaloids come mainly from basophilic taxa whereas species containing a-pyridone alkaloids are acidophilic. Spartiumjunceum is a shrub that plays an important part in recolonization of abandoned fields in Italy. Alkaloid profiles of four dynamically related populations of the shrub in different stages of colonization have been determined with the aid of GC-MS.'28 The alkaloid content -mainly cytisine N-methylcytisine anagyrine and rhombifoline 186 -in a 'pio- neer' population was found to be higher than in mature popu- lations a fact ascribed to the need for the vulnerable invaders to be protected against predators and parasites.A similar argument was used to rationalize high alkaloid levels in plants at an early stage of growth and in growing twigs and repro- ductive organs. The transfer of quinolizidine alkaloids from host plants of the Fabaceae to parasites of the genus Cuscuta (dodder) has been commented on in a previous review.lgk In the latest study on this topic of the 34 alkaloids of the sparteine and lupanine types detected by capillary GLC in four different leguminous hosts (Cytisus praecox Chamaecytisus hirsutus Petteria ramen- tacea and Spartium junceum) 26 were transferred to the parasites Cuscuta reflexa and C.platyl~ba.'~~ In general the alkaloid pattern in the parasite's haustorial region resembled that in the infested stems of the host plant although alkaloid composition changed with distance from the haustoria. The pharmacological and toxicological properties of quino-lizidine alkaloids serve a vital ecological function in the protec- tion of plants against herbivores microorganisms and compet- ing plants. In an attempt to elucidate the mode of action of these allelochemicals the affinities of 14 quinolizidine alkaloids for nicotinic and muscarinic acetylcholine receptor sites in membranes from the porcine brain have been assayed by displacement of specifically bound radiolabelled ligands.129 Cytisine and N-methylcytisine showed good affinity for the nicotinic receptor site but were the least active alkaloids at the muscarinic site with which quinolizidine alkaloids in general interacted rather moderately. The most effective muscarinic binding agents were 13a-tigloyloxylupanine sparteine angus- tifoline 187 albine and multiflorine (IC50 1147 p~).The al- most ubiquitous alkaloid lupanine showed good nicotinic and fair muscarinic receptor affinity (ICs0 5 PM and 114 p~, respect-ively). Pharmacokinetic studies with human volunteers have shown that lupanine and 13-hydroxylupanine unlike sparteine Michael Indolizidine and quinolizidine alkaloids are not metabolized in vivo but are excreted largely unchanged in a short time (t1,2 ca.6 h).130 The protection conferred by lupin quinolizidines against competing plants has been evaluated in a study of their ability to suppress germination of useful crops such as pea wheat and tomato as well as weeds such as winter wi1d-0at.l~' Lupanine showed the greatest antigermination effect especially against the weed while both lupanine and sparteine affected post- germination stages. In general effects of purified alkaloids were greater than those of crude alkaloidal extracts from a variety of Lupinus cultivars and varieties some of them not previously investigated for alkaloid content. The herbicidal effect of the alkaloids has economic implications especially since the large quantities potentially available by 'debittering' seeds used as fodder could find agricultural use.8.3 Structural and spectroscopic studies 13C NMR data have been published apparently for the first time for (+)-5,6-dehydrolupanine 183 and (-)-rhombifoline 186.Io2 These compounds isolated from Anagyrus foetida have not been found previously in the genus Anagyrus. The absolute stereochemistry of 183 was correlated with that of (-)-(7R,9R)-lupanine 171 into which it was converted by hydrogenation over 10% palladium on carbon. (-)-Lupanine and several other known (7R,9R)-tetracyclic and (7R,9S)- tricyclic quinolizidine alkaloids were also isolated in the present study. Continuing investigations on the alkaloidal constituents of Egyptian Lupinus albus L. (=Lupinus termis Forsk.) have revealed another two new natural products.(+)-15p-Hydroxy- 17-oxolupanine 188 constituting 0.017% of the fresh mass of seeds was thoroughly characterized by spectroscopic tech- niques. In particular NMR spectroscopy allowed the deter- mination of relative stereochemistry and also suggested chair conformations for rings C and D. Compound 188 was accompanied by (+)-tetrahydrorhombifoline 189 and very small quantities of (+)-17-oxolupanine 190 from which it is presumably biosynthesized by oxidation. The second new alkaloid (-)-termine 191 also received full spectroscopic characteri~ation.'~~ The chair-chair conformation of rings C and D inferred from chemical shift data and NMR correlation techniques was confirmed by energy minimization using the MM2 molecular mechanics program.A new glycosidic alkaloid (-)-(3'-methoxy-4'-a-~-rhamnosyloxycinnamoy1)epilupinine192 has been isolated as a 5:l mixture of cis and trans isomers from the aerial parts of Lupinus hirsutus. l1 In addition to the customary spectro- scopic evidence the structure of 192 was corroborated by hydrolysis with 3% aqueous hydrochloric acid to rham-nose and the known compound (+)-(4'-hydroxy-3'-methoxycinnamoy1)epilupinine. The latter was hydrolysed in turn with 7% hydrochloric acid to (+)-epilupinine 193. The preferred conformation of sparteine 172 in solution is one in which ring C is a boat. However 13C NMR studies have demonstrated that mono-protonated sparteine and some C-2 and C-15 substituted derivatives exist in the all- chair proton-bridged conformation shown in 194.'32This is in line with recent findings by other workers [see ref.lS(l)]. Dications of 2-substituted A1.2-sparteinium systems on the other hand adopt conformations 195 similar to those of the parent free bases with ring C in the boat form.'33 The same research team has also published further I3C NMR studies on unnatural sparteine derivatives bearing substituents on C-2,'34 as well as a short review describing the synthesis structure and properties of some of these bis-quinolizidine systems.135 13C NMR analysis of eight sparteine derivatives has shown a boat conformation for ring C and axial and equatorial orientations for alkyl substituents on C-6 and C- 17 respectively. 36 A preferred all-chair conformation 187 for (-)-angustifoline a tricyclic lupin alkaloid has been demon- strated with the aid of extensive 'H and I3C NMR studies; product obtained showed no optical activity indicating that minor contributions from other conformations involving epimerization was probably accompanied by a base-induced deformation of rings A and/or C are also involved.'37 Accu- retro-Michael/Michael reclosure process.rate determination of the "HH coupling constants in angusti- foline has been facilitated by a new refinement of the TOCSY experiment.' 38 Recently determined X-ray crystal structures include those of 2-cyan0-2-rnethylsparteine'~~ and the perchlorate hydrate of 11,12-seco-12,13-didehydrornultiflorine196,I4O an alkaloid whose structure has been rather uncertain up to now.The absolute stereostructure of (+)-13P-hydroxymamanine 197 a possible oxidation product of ( -)-baptifoline 198 with which it co-occurs in Maackia amurensis has been established as (7R,9S,11R,13R) by X-ray analysis of its hydrated hydrobro- mide ~a1t.l~' X-Ray analysis of two different crystalline modifications of the ( -)-sparteine-copper(I1) nitrate complex showed mixed four- and five-coordinate geometries around copper in one phase and only a four-coordinate pseudo- tetrahedral geometry in the other.'42 OR H foH aH 199 c ___) 71% + 12% Boc 200 201 202 ii-iv 60% I OH t ent-174 (+)-lupinine 203 204 vii HiA 1 0 0 {OH H H: 188 R=OH 189 ___) (aa 190 R=H ix x (n= 2,rac) 207 n=l rac-193 epilupinine 210 n=2 doTm=cH3 Me + 'OH OH OH 191 termine 192 193 (+)-epilupinine 194 l5 195 R = Me Ph pTol fi HO' 0 197 (+)-1 3P-hydroxymamanine 198 baptifoline 8.4 Synthesis and other chemical studies (9-( +)-Piperidin-2-ylethanol 199 obtained by resolution of the commercially available racemate with (+)-camphorsulfonic acid was used by Knight and co-workers in syntheses of the unnatural (+)-enantiomer of lupinine ent-174 and epilupinine (Scheme 22).143 Stereoselective allylation of the enolate of 200 gave an 84:16 mixture of diastereomers 201 and 202. Isomer 201 was readily converted into (+)-lupinine as illustrated via the bicyclic ester 203. It was expected that epimerization of 203 to the thermodynamically more stable ester 204 would provide access to the epilupinine enantiomer ent-193.However the 36 Natural Product Reports 206 n=l 205 n=l 209 n=2 208 n=2 Scheme 22 Reagents i LiHMDS THF -78 "C then H,C=CHCH,Br -78 "C to room temp.; ii BH,.Me,S hexane 0 "C; iii H,O (30%) NaOH (aq. l%) EtOH reflux; iv MsCl NEt, CH,Cl, 0 "C; v LiAIH, THF-Et,O reflux then recrystallization; vi NaOMe MeOH reflux; vii LiAIH,; viii 9,lO-dicyanoanthracene hv (>320 nm) MeCN N,; ix PhMgBr; x PPTS H,SO,; xi 0, MeOH-CH,Cl,; xii NaBH Irradiation of the a-silylamines 205 in the presence of a sensitizer 9,lO-dicyanoanthracene7 induced a single-electron transfer process that led via the a-amino radical to the forma- tion of a mixture of the isomeric indolizidines 206 and 207 in 43 and 42% yields respe~tive1y.l~~ With the homologous substrate 208 quinolizidines 209 and 210 were produced in yields of 18 and 81YO,respectively.Stereochemical confirmation was pro- vided by conversion of 210 into epilupinine rac-193 (Scheme 22). Presumably 209 could be transformed into lupinine and 207 into tashiromine by the same route. The diazo ketone 211 prepared by alkylating the benzyl ester of L-proline with 5-bromo- 1-diazopentan-2-one7 has been shown to undergo N-alkylation and subsequent [1,2]-Stevens rearrangement via the ammonium ylide 212 to give a mixture of quinolizidinones 213 and 214 (Scheme 23). 145 With copper(I1) acetylacetonate as catalyst the ratio of 213 to 214 was 5:95;but some racemization must have occurred since 214 had an enantiomeric excess of only 75%.A synthesis of (-)-epilupinine ent-193 was completed from 214 by a sequence involving the unusual defunctionalization of thioacetal 215 with sodium and hydrazine in hot ethylene glycol. 21 1 21 2 ent-193 (-)epilupinine 215 21 4 Scheme 23 Reagents i Cu(acac) (5 mol%) toluene reflux; ii HSCH,CH,SH BF,.Et,O; iii LiAlH,; iv Na N,H, HOCH,CHOH heat Few chemical transformations of the lupin quinolizidine alkaloids have been reported during the review period. Esters of the known alkaloid cytisine-12-acetic acid 216 have been prepared by N-alkylation of cytisine 177 with alkyi chloro- acetates in the presence of potassium carbonate 146 while phosphorylation with a variety of reagents yielded com-pounds of type 217.147 The reaction of cytisine with acetone and dimethyl phosphite gave a 55% yield of phosphonate 218.148Addition of methyllithium to multiflorine 175 in diethyl ether at -60 "C yielded predominantly the 1,2-addition product 219 while reaction with methylmagnesium iodide gave largely (4 1) the 1,4-addition product 220.'49The stereochemical preferences in these reactions and the boat conformations of ring C were determined with the aid of 'H and 13C NMR spectroscopy.0 0 216 R = CH2C02H 218 217 R = P(=X)(OR')2; X = 0,S Me H& 219 220 I BuLi 221 x=o 223 222 x=s 224 225 a-isosparteine Michael Indolizidine and quinolizidine alkaloids Uses of ( -)-sparteine 172 as a chiral chelating agent for the lithium cation in asymmetric deprotonations with sec-butyllithium as base continue to proliferate.Hoppe and co-workers' enantioselective deprotonation of the pro3 hydrogen c1 to the oxygen atom of achiral carbamates fol- lowed by reaction with electrophiles provided a highly enan- tioselective (>%YO ee) synthesis of substituted alcohols largely because the lithiated intermediates 221 are configura- tionally stable. 50 The configurationally more labile sulfur analogues 222 led to enantiomeric excesses of 40-60% after reaction with electrophiles (Me,SiCl CO, MeOD). 151 Sparteine-assisted enantioselective deprotonation of oxazolidine-based bis-carbamates prepared from 1,3-diols' 52 and 2-amin0-1,4-diols,' 53 and of the benzylic position in various ortho-alkyl N,N-diisoproprylbenzamides ' 54 was also generally enantioselective; but the sparteine-assisted o-lithiationlsubstitution of the tricarbonylchromium complex of the masked phenol 223 was less impressive (ee 17%)).155 Amongst other enantioselective reactions induced by alkyllithium-( -)-sparteine combinations examples of asym- metric (and frequently helix-selective) polymerization of monomers such as methacrylate have now grown too numer- ous for individual mention.Enantioselective addition reac-tions of organolithium nucleophiles to various imines derived from 4-methoxyaniline (ee 72-9 I YO) have been demon-~trated.'~~ Perhaps the most interesting use of ( -)-sparteine has been as a modifier in the electrocatalytic oxidative coupling of 2-naphthol 2-methoxynaphthalene and 10-hydroxyphenanthrene on a TEMPO-modified graphite felt electrode to give (5')-biaryls such as 224 (ee 91-980/0).157 ( -)-Sparteine's almost-but-not-quite C2 symmetry in the all-chair conformation when coordinated to cations (cf dia-gram 221) has been pointed out as a contributing factor in its successful application to asymmetric transformations.'50 It was thus only a matter of time before the related alkaloid that actually has C symmetry ( -)-a-isosparteine 225 was tested in similar applications. The Korean team of Kang et al. have now demonstrated three quite different uses for this alkaloid (prepared incidentally from ( -)-sparteine rather than being used from a natural source) nucleophilic substitu- tion of racemic allylic acetates by malonate anion with [Pd(x-allyl)isosparteine]' PF -as catalyst (ee 19-880/;1);'58 addition of 2-lithio- 1,3-dithiane to aliphatic and aromatic aldehydes (ee 6-70'240); 59 and [2,3]-Wittig rearrangement of ally1 prop-2-ynyl ethers with sec-butyllithium which proved to be diastereoselective (de 74-100Y0) but only moderately enantioselective (ee 29-71%).9 Petrosin In an audacious approach to the synthesis of the naturally racemic sponge alkaloid petrosin 226 Heathcock and co-workers chose to disregard the alkaloid's stereochemis-try.',' They reasoned that structure 226 represented the most thermodynamically stable diastereomer and was therefore likely to predominate if an acid-catalysed equilibration were to form the final step of the synthesis.They accordingly embarked on the synthesis outlined in Scheme 24 commencing with ozonolysis of methyl oleate to form methyl azelaldehyde 227. A series of homologations and functionalizations yielded cyanoacid 228 one half of which was converted into the amino ester 229. The two moieties were then coupled with DCC to produce amide 230 which after further functional group manipulation was transformed into activated amino ester 231. Macrocyclization under conditions of high dilution afforded the 28-membered bis-lactam 232 in a remarkable 78% yield. This compound contains all the skeletal atoms of the target alkaloid. Once the amide linkages had been reduced and the ensuing amine groups protected the scene was set for con- struction of the quinolizidine rings.Oxidation of all four alcohol groups of 233 with Dess-Martin periodinane followed 37 Me02C-CHO 227 0 xi-xv ___) 230 NH2-HCI 231 xvi 57% from 230 1 !!; OH 229 HO !!H HO xviii-xx xvii xii OH- t- 62% 90% I Boc 234I 233 0 232 236 petrosin B 235 petrosin A 226 petrosin \ I xxi-xxiii 80% J petrosin + petrosin isomers (2 1) Scheme 24 Reagents i pyrrolidine K2C03; ii H,C=CHCN MeCN; iii H,O; iv NaBH, MeOH; v TBDMS-Cl imidazole DMF; vi DIBAL CH,Cl, -95 "C; vii dianion of propanoic acid THF; viii CH,N, Et,O; ix H, PtO, EtOAc HOAc; x DCC hydroxybenzotriazole THF; xi H, PtO, HCl EtOH; xii (BOC),O dioxane H,O; xiii NaOH MeOH THF; xiv DCC C,F,OH THF; xv HCl(6 M) dioxane; xvi high dilution into dioxane-py 90 "C; xvii LiAIH, THF; xviii Dess-Martin periodinane CH,Cl,; xix HCl (1 M) EtOH H,O; xx HOAc (0.2 M) EtOH; xxi Bu'NH, 3 molecular sieves; xxii PrNH3+ OAc- Cl(CH,),Cl; xxiii H20 by deprotection and in situ Mannich reaction yielded via unsuccessful with protic or Lewis acids.However conversion intermediates of type 234 a mixture of isomers (62%) that of the petrosin isomers into the tert-butyl imines provided a included not only crystalline petrosin 226 itself (23%) but also substrate which underwent the desired equilibration. 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Olesker and G. Lukacs Tetrahedron 1995 51 2969. 46 R. H. Furneaux J. M. Mason and P. C. Tyler Tetrahedron Lett. 1995 36 3055. 47 W. K. Anderson and P. Tan Synth. Commun. 1994 24 3081. 48 S. V. Kyosseva Z. N. Kyossev and A. D. Elbein Arch. Biochem. Biophys. 1995 316 821. 49 C. H. Yeung and T. G. Cooper J. Reprod. Fert. 1994 102 401. 50 M. R. Bartlett W. B.Cowden and C. R. Parish J. Leukocyte Biol. 1995 57 207. 51 M. R. E. Bartlett H. S. Warren W. B. Cowden and C. R. Parish Immunol. Cell Biol. 1994 72 367. 52 A. D. Hibberd P. M. Grochowicz Y. C. Smart K. M. Bowen D. A. Clark B. Purdon D. 0. Willenborg and W. B. Cowden Transpl. Proc. 1995 27 448. 53 P. M. Grochowicz A. D. Hibberd K. M. Bowen D. A. Clark G. Pang L. K. Grochowicz D. 0. Willenborg and W. B. Cowden Transpl Proc. 1995 27 355. 54 D. L. Taylor M. S. Kang T. M. Brennan C. G. Bridges P. S. Sunkara and A. S. Tyms Antimicrob. Agents Chemother. 1994 38 1780. 55 C. G. Bridges T. M. Brennan D. L. Taylor M. McPherson and A. S. Tyms Antiviral Rex 1994 25 169. 56 C. G. Bridges D. L. Taylor M. S. Kang T. M. Brennan and A. S. Tyms Glycobiology 1995 5 243.57 D. L. Taylor T. M. Brennan C. G. Bridges M. S. Kang and A. S. Tyms Antiviral Chem. Chemother. 1995 6 143. 58 C. G. Bridges S. P. Ahmed M. S. Kang R. J. Nash E. A. Porter and A. S. Tyms Glycohiology 1995 5 249. 59 S. P. Ahmed R. J. Nash C. G. Bridges D. L. Taylor M. S. Kang E. A. Porter and A. S. Tyms Biochem. Biophys. Res. Commun. 1995 208 267. 60 M. S. Kang P. S. Liu R. C. Bernotas B. S. Harry and P. S. Sunkara Glycobiology 1995 5 147. 61 A. S. Tyms and D. L. Taylor PCT Int. Appl. WO 9419008 A1 940901 (Chem. Abstr. 1994 121 292 767). 62 J. W. Daly Proc. Natl. Acad. Sci. USA 1995 92 9. 63 M. W. Moffett National Geographic 1995 187 98. 64 W. Francke F. Schroder F. Walter V. Sinnwell H. Baumann and M. Kaib Liebigs Ann.Chem. 1995 965. 65 T. T. Shawe C. J. Shiels S. M. Gray and J. L. Conard J. Org. Chem. 1994 59 5841. 66 R. Bloch C. Brillet-Fernandez P. Kiihn and G. Mandville Heterocycles 1994 38 1589. 67 C. Celimene H. Dhimane M. Le Bail and G. Lhommet Tetra-hedron Lett. 1994 35 6105. 68 A. Fleurant C. Saliou J. P. CelCrier N. Platzer T. V. Moc and G. Lhommet J. Heterocycl. Chem. 1995 32 255. 69 M. J. Munchhofand A. I. Meyers J. Am. Chem. Soc. 1995 117 5399. 70 Y. Watanabe H. Iida and C. Kibayashi J. Org. Chem. 1989,54 4088. 71 C. W. Jefford K. Sienkiewicz and S. R. Thornton Tetrahedron Lett. 1994 35 4759. 72 A. M. Castafio J. M. Cuerva and A. M. Echavarren Tetrahedron Lett. 1994 35 7435. 73 R. A. Pilli L. C. Dias and A. 0.Maldaner J.Org. Chem. 1995 60 717. 74 T.-K. Yang S.-T. Yeh and Y.-Y. Lay Heterocycles 1994 38 1711. 75 C. W. Jefford and J. B. Wang Tetrahedron Lett. 1993 34 3119. 76 C. W. Jefford Z.-H. Lu and J. B. Wang Pure Appl. Chem. 1994 66 2075. 77 J. Ahman and P. Somfai Tetrahedron Lett. 1995 36 303 78 G. D. Cuny and S. L. Buchwald Synlett 1995 519. 79 R. P. Polniaszek and S. E. Belmont J. Org. Chem. 1990 55 4688. 80 T. J. Bond R. Jenkins and P. C. Taylor Tetrahedron Lett. 1994 35 9263. 81 J. J. Kiddle D. L. C. Green and C. M. Thompson Tetrahedron 1995 51 2851. 82 D. F. Taber M. Rahimizadeh and K. K. You J. Org. Chem. 1995 60 529. 83 P. Jain H. M. Garraffo T. F. Spande H. J. C. Yeh and J. W. Daly J. Nut. Prod. 1995 58 100.84 C. Kibayashi Pure Appl. Chem. 1994 66 2079. 85 D. N. A. Fox D. Lathbury M. F. Mahon K. C. Molloy and T. Gallagher J. Am. Chem. Soc. 1991 113 2652. 86 T. M. Bargar R. M. Lett P. L. Johnson J. E. Hunter C. P. Chang D. J. Pernich M. R. Sabol and M. R. Dick J. Agric. Food Chem. 1995 43 1044. 87 L. E. Overman and M. J. Sharp Tetrahedron Lett. 1988,29,901. 88 D. F. Taber and K. K. You J. Am. Chem. Soc. 1995 117 5757. 89 R. K. Gupta J. Singh and D. D. Santani Ind. J. Chem. 1995 34B 76. 90 F. Abe Y. Iwase T. Yamauchi K. Honda and N. Hayashi Phytochernistry 1995 39 695. 91 E. Eibler U. Tanner K. K. Mayer W. Wiegrebe and H. Reger Acta Pharm. Zagreb 1995 45 487 (Chem. Abstr. 1995 123 310 403). 92 W. H. Pearson and R. Walavalkar Tetrahedron 1994 50 12 293.93 H. Suzuki S. Aoyagi and C. Kibayashi Tetrahedron Lett. 1995 36 935. 94 A. Rother and J. M. Edwards Phytochemistry 1994 36 911. 95 R. A. Pilli L. C. Dias and A. 0. Maldaner Tetrahedron Lett. 1993 34 2729. 96 The Science of Legumes ed. T. Aniszewski 1994 1. 97 T. Aniszewski Sci. Legumes 1994 1 1 (Chem. Abstr. 1995 123 251 130). 98 S. Ohmiya K. Saito and I. Murakoshi in The Alkaloids. Chem- istry and Pharmacology ed. G. A. Cordell Academic Press San Diego 1995 vol. 47 ch. 1 p. Iff. 99 K. Saito and I. Murakoshi in Studies in Natural Product Chem- istry ed. Atta-ur-Rahman Elsevier Science Amsterdam 1995 vol. 15 p. 519ff. 100 D. J. Robins in The Alkaloids. Chemistry and Pharmacology ed. G. A. Cordell Academic Press San Diego 1995 vol.46 ch. 1 p. Iff. 101 V. Christov H. Dutschewska G. Stoev D. Selenghe S. Zhavsan and Y.Zhamyansan Dokl. Bulg. Akad. Nauk 1994,47,27(Chem. Abstr. 1995 123 52 360). 102 M. M. Al-Azizi M. S. Al-Said M. M. El-Olemy E. Abdel Sattar and A. S. Khalifa Arch. Pharmacal Res.. 1994 17 393 (Chem. Abstr. 1995 122 261 133). 103 L. C. Marinho M. T. M. Carneiro da Cunha G. Thomas and J. M. Barbosa-Filho Fitoterapia 1994 65 475. 104 P. Baumel L. Witte F.-C. Czygan and P. Proksch Biochem. Syst. Ecol. 1994 22 647. 105 F. Tosun A. Tosun M. Tanker and T. Ozden J. Fac. Pharm. Gazi 1994 11 197 (Chem. Abstr. 1995 122 286 581). 106 M. H. Mohamed Z. Z. Ibraheim 0. M. Abdallah and I. Murakoshi Phytochemistry 1994 37 175 1. 107 M.H. Mohamed A. M. P. Koskinen and M. S. Kamel Bull. Pharm. Sci. Assiut Univ.,1995 18 55 (Chem. Abstr. 1996 124 4886). 108 W. Wysocka and A. K. Przybyl Sci. Legumes 1994 1 37 (Chem. Abstr. 1995 123 192 835). 109 W. Majak W. J. Keller Z. Duan D. Munro R. A. Smith A. M. Davis and R. T. Ogilvie Phytochemistry 1994 36 883. 110 M. Wink and D. B. Carey Biochem. Syst. Ecol. 1994 22 663. 111 H. Suzuki Y. Koike S. Takamatsu T. Sekine K. Saito and 1. Murakoshi Phytochemistry 1994 37 59 1. 112 X.-Z.Meng and R.-M. Zhang Acta Prataculturae Sinica 1995,4 6. 113 X. Wang J. Li L. Wei and S. Omiya Zhongguo Zhongyao Zazhi 1995 20 168 (Chem. Abstr. 1995 122 310 740). 114 E. F. Merino and A. M. Planchuelo Sci. Legumes 1994 1 86 (Chem. Abstr. 1995 123 222 742).115 A. M. Planchuelo Sci. Legumes 1994 1 81 (Chem. Abstr. 1995 123 222 741). 40 Natural Product Reports 116 X.-Z. Meng X.-Q. Hu R.-M. Zhang and Y.-T. You Zhong-caoyao 1994 25 61 (Chem. Abstr. 1994 121 53 916). 117 X.-Z. Meng X.-Q. Hu R.-M. Zhang and Y.-T. You Biochem. Syst. Ecol. 1994 22 858. 118 T. Aniszewski Sci. Legumes 1994,1,25 (Chem. Abstr. 1994,123 196 806). 119 T. Aniszewski Sci. Legumes 1995 1 111 (Chem. Abstr. 1995 123 192 939). 120 J. Pothier J. C. Dore N. Galand and C. Viel Analusis 1995 23 71. 121 M. Wink C. Meissner and L. Witte Phytochemistry 1995 38 139. 122 E. Kass and M. Wink Botanica Acta 1995 108 149. 123 M. Muzquiz C. Cuadrado G. Ayet C. de la Cuadra C. Burbano and A. Osagie J. Agric. Food Chem.1994 42 1447. 124 M. Fritea Sci. Legumes 1994 1 97 (Chem. Abstr. 1995 123 223 047). 125 C. de la Cuadra M. Muzquiz C. Burbano G. Ayet R. Calvo A. Osagie and C. Cuadrado J. Sci. Food Agric. 1994 66 357. 126 R. Greinwald I. van Rensen M. Veit P. Canto and L. Witte Biochem. Syst. Ecol. 1995 23 89. 127 R. Bernasconi S. Gill and E. Steinegger Pharm. Acta Helv. 1965 40 275. 128 L. Barboni A. Manzi B. Bellomaria and A. M. Quinto Phyto-chemistry 1994 37 1197. 129 T. Schmeller M. Sauerwein F. Sporer M. Wink and W. E. Miiller J. Nat. Prod. 1994 57 1316. 130 D. S. Petterson B. N. Greirson D. G. Allen D. J. Harris B. M. Power L. J. Dusci and K. F. Ilett Xenobiotica 1994 24 933. 131 M. Muzquiz C. de la Cuadra C. Cuadrado C. Burbano and R.Calvo Ind. Crops and Prod. 1994 2 273 (Chem. Abstr. 1995 122 3454). 132 W. Boczon J. Skolik and B. Koziol J. Mol. Struct. 1994 328 1. 133 J. Skolik W. Boczoii and B. Koziol J. Mol. Struct. 1994,328 11. 134 B. Koziol and W. Boczon Sci. Legumes 1994 1 51 (Chem. Abstr. 1995 123 286 360) 135 W. Boczon and B. Koziol Sci. Legumes 1994 1 63 (Chem. Abstr. 1995 123 286 346). 136 U. Majchrzak-Kuczyiiika P. Pietrzak and J. Skolik Pol. J. Chem. 1995 69 25 (Chem. Abstr. 1995 122 291 247). 137 W. Wysocka A. Przybyl and T. Brukwicki Monatsh. Chem. 1994 125 1267. 138 W. Willker and D. Leibfritz J. Magn. Reson. Ser. A 1994 110 95. 139 I. Wolska and T. Borowiak Acta Crystallogr. Sect. C 1995 51 1158. 140 G. Dutkiewicz M. Kubicki T. Borowiak and W.Wysocka Acta Crystallogr. Sect. C 1995 51 1182. 141 H. Kubo S. Ohmiya K. Higashiyama K. Kawai K. Saito and I. Murakoshi Chem. Pharm. Bull. 1994 42 1706. 142 S.-N. Choi M.-A. Kwon Y. Kim R. D. Bereman P. Singh B. Knight and K. Seff J. Coord. Chem. 1995 34 241. 143 C. Morley D. W. Knight and A. C. Share J. Chem. Soc. Perkin Trans. I 1994 2903. 144 S. E. Hoegy and P. S. Mariano Tetrahedron Lett. 1994,35 8319. 145 F. G. West and B. N. Naidu J. Am. Chem. Soc. 1994,116 8420. 146 0. A. Nurkenov A. M. Gazaliev A. K. Zhakina and M. Z. Zhurinov Izv. Nats. Akad. Nauk Resp. Kaz. Ser. Khim. 1994 74 (Chem. Abstr. 1995 123 56 346). 147 A. M. Gazaliev B. 1. Tulenov K. D. Mukanova 0. A. Nurk- enov A. K. Zhakina and M. Z. Zhurinov Izv. Nats.Akad. Nauk Resp. Kaz. Ser. Khim. 1994,80 (Chem. Abstr. 1995,123 56 347). 148 S. D. Fazylov A. M. Gazaliev L. M. Vlasova and R. Z. Kasenov Zh. Obshch. Khim. 1995 65 877 (Chem. Abstr. 1995 123 228 605). 149 J. Thiel W. Wysocka and W. Boczon Monatsh. Chem. 1995 126 233. 150 D. Hoppe F. Hintze P. Tebben M. Paetow H. Ahrens J. Schwerdtfeger P. Sommerfeld J. Haller W. Guarnieri S. Kolc-zewski T. Hense and I. Hoppe Pure Appl. Chem. 1994,66 1479. 151 B. Kaiser and D. Hoppe Angew. Chem. Int. Ed. Engl. 1995 34 323. 152 M. Paetow M. Kotthaus M. Grehl R. Frohlich and D. Hoppe Synlett 1994 1034. 153 W. Guarnieri M. Grehl and D. Hoppe Angew. Chem. Int. Ed. Engl. 1994 33 1734. 154 S. Thayumanavan S. Lee C. Liu and P. Beak J. Am. Chem. Soc. 1994 116 9755.155 M. Uemura Y. Hayashi and Y. Hayashi Tetrahedron Asym- metry 1994 5 1427 156 S. E. Denmark N. Nakajima and 0.J.-C. Nicaise J. Am. Chem. 159 J. Kang J. I. Kim and J. H. Lee Bull. Korean Chem. SOC.,1994 SOC.,1994 116 8797. 15 865 (Chem. Abstr. 1995 122 105 786). 157 T. Osa Y. Kashiwagi Y. Yanagisawa and J. M. Bobbitt 160 J. Kang W. 0.Cho H. G. Cho and H. J. Oh Bull. Korean Chem. J. Chem. SOC., Chem. Commun. 1994 2535. SOC.,1994 15 732 (Chem. Abstr. 1995 122 160 741). 158 J. Kang W. 0. Cho and H. G. Cho Tetrahedron Asymmetry 161 R. W. Scott J. R. Epperson and C. H. Heathcock J. Am. Chem. 1994 5 1347. SOC.,1994 116 8853. Michael Indolizidine and quinolizidine alkaloids

ISSN:0265-0568    

DOI:10.1039/NP9971400021

出版商:RSC    

年代:1997

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The Royal Society of Chemistry Perkin Division and Bioorganic Group International interdisciplinary Conference Polyketides I1 Chemistry Biochemistry and Molecular Genetics RRIS'WL 1998 University of Bristol 8-10 July 1998 The Royal Society of Chemistry's Perkin Division and Bioorganic Group are pleased to extend an invitation to all interested parties to attend the second cross-disciplinary International Conference on Polyketides- Chemistry Biochemistry and Molecular Genetics. This meeting follows the highly successful conference which was held in Bristol in April 1996. The following persons have agreed to give keynote or invited lectures at the conference John Cronan Universityof Illinois USA Eric Cundliffe Universityof Leicester UK Hans von Dohren Technical University of Berlin Germany Heinz Floss Universityof Washington,USA Melvyn Gill Universityof Melbourne Australia David Hopwood John lnnes Centre UK J un'ichi Kobayashi Hokkaido University Japan Richard Hutchinson Universityof Wisconsin USA Peter Leadlay Universityof Cambridge UK Leonard Katz AbbotfLaboratories USA Haideh Motamedi Merck Research Laboratories USA Michio Murata Universityof Tokyo Japan Jurgen Rohr University of South Carolina USA Elisabeth Schneider-Scherzer Biochemie GmbH Austria Joe Schroder University of Freiburg Germany Michael Schweizer Institute of Food Research UK Tom Simpson Universityof Bristol UK Stuart Smith Oakland Research Institute USA Jim Staunton University of Cambridge UK Bill Strohl Merck Research Laboratories USA Craig Townsend John Uopkins University USA Sali h Wakil Baylor College of Medicine USA Chris Walsh Harvard University USA Paul Williams Universityof Nottingham UK Polyketides comprise a major group of natural products which display a wealth of structural variety and a diverse range of important biological activities.Major advances have been stimulated by work in several areas including chemical synthesis structure elucidation biosynthesis and molecular genetics. The aim of this conference is to bring together leading experts from different disciplines to provide a comprehensive update of recent progress and to discuss future developments and priorities in polyketides research and closely related areas of fatty acid metabolism. In addition downstream tailoring of polyketides e.g.glycosylation and biosynthesis of deoxysugars structure and biosynthesis of marine toxins and relationships with non-ribosomal peptide syntheses will be featured. The programme will consist of keynote and other invited lectures a limited number of offered oral contributions and a poster session with the posters forming an integral part of the meeting. Persons wishing to offer an oral or a poster contribution should contact Dr Gerry Montgomery at the address given below. The closing date for the submission of all abstracts is Monday 19 January 1998 Further Information from Dr Gerry Montgomery Polyketides II,The Royal Society of Chemistry Burlington House Piccadilly London W1V OBN UK Fax t44(0)171 734 1227 Email montgomeryg @rsc.org (using the subject header 98PW1CC) Web http://chemistry.rsc.org/rsc/confs.htm Organic Process Research & DeveIopment KEY FEATURES 0Substantive articles and reports from leading researchers 0Reports on original work in process chemistry 0Reports on scale up of processes to pilot plant with discussions of safety and environmental issues 0 Special focus on the design of chemical processes and their development and scale up from laboratory to manufacture 0 Current R&D in the fine organic and speciality chemical industries 1998 PricinE ~ 6 issues a year ISSN 1083-6160 UK & Europe f289.00 Customers outside of Europe should obtain dollar prices and order from the ACS ’ “At last a journal covering an area which we*in industrial Process R&Dare very much involved in ...~-the issues presented so far have met all my expecta- tions with regard to topics quality of papers and size. The editors are to be congratulated for suc- ceeding in such a formidable way by simply saying what a wonderful start!” H-J Federne4 Associate Professor Senior Manager Process Chemisfry Development Asfra froduction Chemicals Sweden. “OPR&D is the long missing platform for industrial and academic chemists to exchange specific results in the field ... Iwould like to wish the editors and the journal further success and an ever growing com-munity of readers.” Professor B Kutscher Director Chemical Research ASTA Medica Germany ”A dedicated high quality journal covering all aspects of the discipline.Congratulations to the whole team at the first anniversary of OPR&D. Industry has subscribed massively but also universi-ties and schools should not miss this opportunity. OPR&D is valuable and real life feedback from industry and can help bridge the gap. I wish you lots of success for many years to come.” F De Knaep Director Process Research Janssen Pha rmaceutica Belgium To order please contact *&UK & Europe USA & Rest of World For further information on this or The Royal Society of Chemistry The American Chemical Society any other RSC product or z; Turpin Distribution Services Ltd Customer Service and Sales service,visit our website on 6 CHEMISTRY d Blackhorse Rd Letchworth 1155 Sixteenth Street NW http://chemistry.rsc.org/rsc/ Y Herts SG8 1HN Wahington DC 20036 USA e-mail sak@rsc.org c: 9 Tel+44 (0)1462 672555 Tel +1 202-776-8100 5 Fax +44 (0)1462 480947 Fax +1 202-872-6067 7 k! 4 Information 8 Services N RSC & ACS Members are entitled to a discount. Please contact your society for further details

ISSN:0265-0568    

DOI:10.1039/NP99714BP023

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年代:1997

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The Royal Society of Chemistry Natural Product Reports Editorial Board Professor T J Simpson (Bristol) Chair Dr S L Flitsch (Edinburgh) Dr J R Hanson (Sussex) Dr R B Herbert (Leeds) Professor G Hofle (GBF Germany) Professor J Mann (Reading) Dr D O’Hagan (Durham) Professor D J Robins (Glasgow) Dr C J Schofield (Oxford) Professor J C Vederas (Edmonton Canada) Dr D A Whiting (Nottingham) Editorial Staff Publishing Dr Sheila R Buxton Managing Editor Dr Roxane M Owen Deputy Editor Mrs Dawn J Webb Editoriul Secretary Editorial Office The Royal Society of Chemistry Thomas Graham House Science Park Cambridge UK CB4 4WF International Advisory Board Dr S J Gould (Rahway NJ) Professor H G Floss (Washington OR) Professor L N Mander (Canberra) Professor K Mori (Tokyo) Editorial Staff Production Miss Nicola P Coward Editoriul Production Coordinator Dr Carmel M McNamara Technical Editor Tel+44 (0) 1223 420066 Fax +44 (0) 1223 420247 E-mail perkin@rsc.org RS C Server http //c hemis try.rsc .org/rsc/ Advertisement sales Tel+44 (0) 1223 432240.Fax +44 (0) 1223 426017 Information for Authors Nutural Product Reports is a bimonthly journal of critical reviews. It aims to foster progress in the study of bioorganic chemistry by providing regular and comprehensive reviews of the relevant literature published during well-defined periods. Topics include the isolation structure biosynthesis biological activity and chemistry of the major groups of natural products -alkaloids terpenoids and steroids aliphatic aromatic and 0-heterocyclic compounds.This is augmented by frequent reviews of the wider context of bioorganic chemistry including developments in enzymology nucleic acids genetics chemical ecology primary and secondary metabolism and isolation and analytical techniques which will be of general interest to all workers in the area. Articles in Natural Product Reports are generally commissioned by members of the Editorial Board but the Society is always prepared to consider offers of articles for publication. In such cases a short synopsis rather than the completed article should be submitted to the Managing Editor at the address given above. Natural Product Reports (ISSN 0265-0568) is published bimonthly by The Royal Society of Chemistry Thomas Graham House Science Park Milton Road Cambridge UK CB4 4WF.1998 Annual subscription rate 2380.00. US$685.00. Customers in Canada will be charged the sterling price plus a surcharge to cover GST. Change of address and orders with payment in advance to The Royal Society of Chemistry Turpin Distribution Services Limited Blackhorse Road Letchworth Herts. UK SG6 1HN. Air freight and mailing in the USA by Publications Expediting Service Inc. 200 Meacham Avenue Elmont NY 11003. US Postmaster send address changes to Natural Product Reports Publications Expediting Service Inc. 200 Meacham Avenue Elmont NY 11 003. Periodicals postage paid at Jamaica NY I 143 1-9998. All other despatches outside the UK are by Bulk Airmail within Europe and Accelerated Surface Post outside Europe. The RSC primary and review journals are now available electronically via the Internet. If you take a full price institutional subscription to any RSC primary or review journal you are entitled to free site-wide electronic access to that journal. To access the electronic versions as soon as possible please contact Avril Ross at TDSL Turpin@rsc.org to register your IP addresses. PRINTED in the UK by Henry Ling Ltd at the Dorset Press Dorchester Dorset. 0The Royal Society of Chemistry 1998. All Rights Reserved. No part of this publication may be reproduced stored in a retrieval system or transmitted in any form or by any means electronic mechanical photographic recording or otherwise without the prior permission of the publishers.

ISSN:0265-0568    

DOI:10.1039/NP99714FX029

出版商:RSC    

年代:1997

数据来源: RSC

ISSN:0265-0568    

DOI:10.1039/NP99714BX031

出版商:RSC    

年代:1997

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~ Lignans neolignans and related compounds Robert S. Ward Chemistry Department University of Wales Swansea Singleton Park Swansea UK SA2 8PP Covering January 1994 to December 1995 Previous review 1995 12 183 1 Introduction 1.1 Analysis and identification 1.2 Biological activity 1.3 Biosynthesis and metabolism 2 Lignans 2.1 Dibenzylbutanes and dibenzylbutanediols 2.2 Dibenzylbutyrolactones 2.3 Substituted tetrahydrofurans 2.4 2,6-Diaryl-3,7-dioxabicyclo[3.3. Oloctanes 2.5 Arylnaphthalene derivatives 2.6 Dibenzocyclooctene derivatives 2.7 Miscellaneous lignans 3 Neolignans 4 Oligomeric lignans and neolignans 5 Hybrid lignans 6 Norlignans 7 References 1 Introduction This report is presented in essentially the same style and format as the previous two reports in the series.',2 In addition the abbreviations used for different aryl groups are continued (Fig.1). Although with hindsight a more logical classification is conceivable for the sake of continuity and ease of cross referencing the previous practice is retained. A regrettable feature of the literature coverage of this and presumably other areas of natural product chemistry is the proliferation of incorrect names and structures which lead not only to con- fusion but also result in several names often being assigned to the same compound. In an effort to collect together the names given to known members of some of the main lignan series a number of charts are included in this report which list known members of some lignan classes.Others can be added in future reports and notification of any errors or omissions would be appreciated for inclusion at that time. Two recent reviews deal with the occurrence and distri- bution of lignans and the evolution of lignan and neolignan biochemical pathway^.^,^ A strong case is made to support the idea that the phenylpropanoid pathway and associated meta- bolic routes can be used as an aid to the classification of plant OH LOMe species. Based on existing chemotaxonomic data organisms can be distinguished by differences in the degree and extent of phenylpropanoid metabolism. It is proposed that these differ- ences could be of considerable importance in cataloguing the biodiversity of plant life and in charting metabolic evolution.Two further reviews survey the lignans isolated from Linurn and Fursythia species with particular emphasis on in vitro cell culture studies including their use for the production of cytotoxic lignans and in defining biosynthetic pathway^.^,^ A further recent review covers the occurrence and distribution of lignans in ~oniferae.~ 1.1 Analysis and identification Increasing attention is being focused on finding appropriate methods for the analysis of lignans and neolignans from plant sources and in body fluids. A comparison of different methods applied to lignan analysis of seed oils from sesame seeds has been publi~hed.~,~ It concluded that although GC was good for qualitative analysis it has a number of limitations for quantita- tive work most notably the preparative steps involved the difficulty of finding a suitable internal standard and the mark- edly different response factors of the compounds studied.In contrast HPLC was found to be a better method for rapid quantitative analysis although both normal-phase and reverse- phase columns were necessary to deal with the varied compounds present. Reverse-phase HPLC has been used in combination with photodiode array detection to analyse neo- lignans isolated by supercritical CO extraction from Magnolia virginiana flowers.lo Reverse-phase HPLC has also been used to provide a rapid and reliable method for the routine analysis of podophyllotoxin and related compounds in Podophyflum extracts.11,12 Chiral HPLC combined with FAB mass spectrometry has been used to study the enantioselective formation of (-)-secoisolariciresinol in cell-free extracts of Forsythia koreana. l3 Both LC-MS and GC-MS have been applied to analysing samples containing the mammalian lignans enterolactone and enterodiol and their precursors matairesinol and secoisolar- iciresinol. These studies are particularly important in view of the claimed protective effects of these compounds against breast prostate and colon cancer (see Section 1.2).Thus HPLC coupled with either ionspray or continuous-flow FAB mass spectrometry provides a rapid method for the detection and identification of secoisolariciresinol diglucoside in flaxseed extracts.14,15 Interestingly two isomers presumed to be OMe OMe OMe \ Med OMe Fig. 1 Abbreviations used for different aryl groups Ward Lignans neolignans and related compounds diastereoisomers were revealed by this work. It is claimed that identification and characterisation of such samples can be carried out on crude extracts with minimal sample manipu- lation since there is no need for preparative isolation of each component. So far GC-MS using single ion monitoring would seem to be the method of choice for analysing the mammalian lignans and isoflavonoid phytoestrogens in human plasma. l6 The combi- nation of isotope dilution GC-MS using the deuteriated com- pounds as internal standards provides a powerful tool for quantitative determination of plasma phytoestrogen levels as low as 0.2-1.0 nmol 1 -'.l77l8 A simple and reliable method involving single ion monitoring with GC-MS has also been developed for the determination of schizandrin in human plasma." It is anticipated that this will be invaluable in monitoring pharmacokinetic studies on this compound.A comprehensive compilation of I3C NMR data for lignans and neolignans has been published which will be especially useful for establishing the parent skeleton and substitution pattern of the side chains.20 1.2 Biological activity Analogues and derivatives of podophyllotoxin continue to be investigated in an effort to improve upon the antitumour activity of the clinical drug etoposide. A wide range of derivatives have been ~repared.~'-~' Some which show particu- lar promise in terms of improved activity or have other advantages are shown in Fig.2. Aa 1 R = CHO (ref. 23) 3 R = N3 (ref. 24) 2 R = CH=NNHPh (ref. 23) 4 R = NH2 (ref. 24) NHAr 5 (refs. 25,26) 6 Ar = 4-FCeH4 (refs. 27,29) 7 Ar = 4-N02C6H4 (ref. 27) n 8 (ref. 28) 9 Ar = 4-N02C6H4 (ref. 31) Fig. 2 Biologically active podophyllotoxin analogues Thus 4-O-butanoyl-4'-demethylpodophyllotoxin5 is cyto- toxic at concentrations 100-1000 times lower than conven-tional drugs and is active against several drug resistant tumour cell line^.^^,^^ Similarly the 4-arylamino derivatives 6 and 7 are up to 100 times more active than etoposide and also show activity against etoposide resistant while compounds such as 8 which can form water soluble salts have increased antitumour activity and improved drug resistance,28 and compounds such as 9 which probe the 'intercalating domain of the pharmacophore' exhibit improved activity and have a novel mechanism of action.31 Both forcefield calculations and a three-dimensional QSAR study have been implemented in the quest for compounds based on podophyllotoxin with enhanced acti~ity.*~>~' The antitumour activity of the foliage of Libocedrus plumosa has been shown to be due to the presence of b-peltatin (Section 2.5).32 Although often overlooked due to the considerable atten- tion devoted to podophyllotoxin derivatives it is worth remembering that other classes of lignans also exhibit anticancer activity.According to a recent paper some 36 naturally occurring lignans having anticancer activity have been reported.33 They include arctigenin and trachelogenin (Section 2.2) burseran (Section 2.3) liriodendrin and styraxin (Section 2.4) diphyllin (Section 2.5) and steganacin and steganangin (Section 2.6). Although the figure of 36 is probably a conservative estimate even based on current data it emphasises the need to broaden the scope of current investigations. A recent study has shown that four com-pounds machilin A 10 matairesinol 11 arctigenin 12 and honokiol 13 from a group of eleven lignans and neolignans studied had activity comparable to that of current anticancer agents.34 The menthyloxy substituted dibenzylbutyrolactones 14a and 14b also showed activities comparable to etoposide teniposide and ~isplatin,~~ whereas a series of chloro and iodo di benzyl butyrolac tone derivatives showed diminished activity when compared with yatein or podophyll~toxin.~~ Ar2 Ar5 Ar3 10 11 Ar=Ar3 12 Ar=Afl RO AS 0 13 14a R=H 14b R = CH2CHPOEt Meanwhile there is growing evidence that the consumption of foods rich in lignans can decrease the risk of contacting certain forms of Various mechanisms have been suggested whereby these compounds exert their protective effects.For example the lignans may contribute towards the prevention of breast cancer as a result of their antiestrogenic properties whereby they interact with the estrogen receptor and modulate the action of estrogen.Alternatively they may act as antioxidants and prevent the production of carcino- gens from estrogen or they may inhibit aromatase enzyme activity and thereby contribute to the prevention of hormone dependent cancers. Several other examples of useful biological activity have been reported. Thus both syringaresinol and yangambin (Section 2.4) show significant antiplatelet aggregation The Na and K salts of 15 and 16 which are known tetramers of caffeic acid have been isolated from Arnebia euchroma and shown to possess potent anti-HIV activity.44 A number of lignans isolated from Larrea tridentata including 3- O-methyl- nordihydroguaiaretic acid also display anti-HIV activity.45 Analogues of justicidin E (Section 2.5) have been shown to be potent inhibitors of leukotriene biosynthesis and non-redox inhibitors of 5-lipoxygenase As such they could form the basis of a new class of therapeutic agents for the treatment of disease states such as asthma inflammatory bowel disease 44 Natural Product Reports and rheumatoid arthritis.Some 4-hydroxyarylnaphthalene lig- nans are hypolipidemic agent^.^' The most potent which have greater activity than other known agents not only reduce serum cholesterol levels but also increase high-density lipoprotein levels in rats. HO 15 16 The inhibitory activity of podophyllotoxin derivatives on the root growth of Brassica campestris has been ascribed to the presence of the methylenedioxy group and the configur-ation of the lactone ring while the activity of matairesinol was enhanced by methylation of the two phenolic groups.48 Mean- while there is evidence that bis(methy1enedioxy)cinnanic acid derivatives inhibit the lignin peroxidase from Phanerochaete chryso~poriurn.~~ These results support the hypothesis that the accumulation of lignans at the site of a wound may inhibit the fungal enzymes involved in lignin degradation.The corre- sponding tetrahydro derivatives and the corresponding 3,4-dimethoxy compounds were considerably less active. The lignan components of Schizandra chinensis fruits which have been used in traditional Chinese medicine for many years have been shown to have a protective effect against liver damage caused by toxic chemicals. Gomisin A in particular induces liver microsomal enzymes accelerates liver regenera- tion and inhibits the promotion of hepatocarcinogene~is.~~~~~ The biological activities of several lignans and flavonoids iso- lated from traditional medicines have been summarised in a recent paper.s2 Finally the antioxidative properties of sesame seeds which have long been used as a health food to prevent ageing appear to be related to their lignan component^.^^ It has now been shown that the lignans act synergistically with a-tocopherol leading to an enhancement of vitamin E activity.1.3 Biosynthesis and metabolism A clear picture of the principle pathways of lignan biosynthesis in For~ythia,~.~~,~~ is emerging and also now in Zantho~ylum,~~ from studies using labelled precursors and cell free extracts.The sequence from coniferyl alcohol to (+)-pinoresinol (+)-lariciresinol ( -)-secoisolariciresinol and ( -)-matairesinol seems to be clearly established and the occurrence of ( -)- pinoresinol and ( -)-lariciresinol in these species is probably due to the intervention of a second non-selective pathway. The promotive effect of high intensity light on the induction of flowering of Morning Glory seedlings by low temperature treatment has been correlated with enhanced phenylpropanoid biosynthesis and may be due to an increase in hydrogen peroxide production in response to stress induced by the low temperature.57 Model experiments using isolated enzymes and inorganic reagents continue to be of interest in a biomimetic context Ward Lignuns neolignans and related compounds particularly when they yield novel and interesting products.For example oxidative coupling of methyl sinapate using horseradish peroxidase and H,O in methanol affords the dimeric products 17 and 18 whereas in aqueous acetone 19 is the major pr~duct.~' Treatment of 17 and 18 with aqueous acid gives 20. This is of interest in that it rules out the possibility of 17 and 18 being involved in the formation of 19 which must therefore be formed by direct cyclisation. Mb$*;;Me C02Me Me:hy*;;Me C02Me Me0 0 OMe 0 OMe 17 18 w MeOpCO2Me H OOMe 0 2 M e HO \ . C02Me Me0 \ . C02Me OMe Ar7 A17 19 20 Oxidation of the biphenyl derivatives 21 with horseradish peroxidase (HRP) and H202in the presence of an equimolar amount of coniferyl alcohol gave the novel eight-membered ring products 22 [reaction (l)].59 This ring structure has been identified as a component in softwood lignins.Me0 OH R R wR Ar3ZCHZ01 HRP R HO OMe Me0 21 R = Pr or CH20H APt-( CH20H 22 Silver oxide oxidation of isoeugenol in dichloromethane affords a dimeric quinone-methide which on quenching with methanol or water affords the neolignans 23 and 24 the latter being closely related to the natural product viriolin which has antileukaemic properties.60 In benzene solution oxidation yields the dihydrobenzofuran 25. Me OMe 23 R=Me 25 24 R=H Silver oxide oxidation of coniferyl alcohol in dry dichloro- methane or acetone affords dehydrodiconiferyl alcohol 26 while in 1:1 dichloromethane-water pinoresinol is the major product.61 Once again there is good evidence for the involve- ment of quinone-methide intermediates since reactions over shorter periods followed by quenching with aqueous acid or reaction in aqueous acidic solution leads to the formation of a-and P-linked aryl ethers 27 and 28.CH20H HO OMe A r3 OMe 26 27 CH20H Me0-Q o~~H~cH20H A r3 28 Silver oxide oxidation of ethyl ferulate gives the ethyl ester of dehydrodiferulic acid 29.62In fact seven dehydrodimers of ferulic acid (29-35) have been synthesised and shown to be present in extracts from saponified cell walls of various grasses. They are forrned in nature by dimerisation of ferulic acid residues which are esterified to grass cell wall polysaccharides.They have the potential to cross-link polysaccharides to lignin in the cell wall perhaps providing a template for lignification. Oxidative coupling of the 4-hydroxycinnamic acid esters 36a and 36b affords the dihydronaphthalenes 37a and 37b respectively as the major products [reaction (2)].63 The 2-hydroxycinnamic acid esters 38a and 38b in contrast yield OMe OMe 29 30 'O2'V $H o\ I I OMe AP C02H 31 32 OMe OMe 33 the enol acetate derivatives 39a and 39b respectively after acetylation [reaction (3)]. C02Me HO C02Me R2& 02Me MOMOR i C02Me ~ i. [O] ii. Ac20 MOM0 OH 2 Lignans 2.1 Dibenzylbutanes and dibenzylbutanediols Characterisation of the lignans from Larrea tridentata which display anti-HIV activity has led to the isolation of new compounds 4@-43.45 The absolute configurations of oleiferins A-C (4446) have been confirmed by acid-catalysed Friedel- Crafts cyclisation to (+)-isogalcatin ( -)-galcatin and ( -)-cagayanin re~pectively.~~ Anolignans A and B (47 and 48) are newly reported lignans which have been isolated from the stems of Anogeissus acuminata.66 Two further new lig- nans in this group are cinnamophilin 49 from the root of Cinnamonum philippinen~e~~ and 4"-O-methyl-3'-O-demethyl-secoisolariciresinol 50 from the needles of Taxus baccata.68 Fig.3 shows the structures of symmetrically substituted members of the dibenzylbutane and dibenzylbutanediol series.As illustrated by the names of some compounds already mentioned (e.g. 50) workers have often chosen to A P T Af'T Ar2F Ar27 A14 Ar16 Ari6 Ar' 40 41 42 43 Ar5 Ar 44 oleiferin A 45 Ar = Af' oleiferin 6 46 Ar = Ar5 oleiferin C Ar'T Ar2T:; HO A$f A14 "X Meomco2H HO C02H H02C A13 Ar' Ar' A+ 34 35 47 48 49 50 46 Natural Product Reports assign names to compounds based upon their structural relationship to supposedly well known parent compounds. It is not always obvious especially to newcomers to this field what the origins of such names are or what relationship exists between compounds with apparently similar trivial names. In the hope of providing clarification some examples of this practice are highlighted in this report.Thus the guaiaretic acid family are shown in Fig. 4 and the lariciresi- no1 family appear in a later figure (Fig. 11). Ar = Arl conocarpol Ar = Ar2 mesenordihydroguaiareticacid Ar = Ar3 mesedihydroguaiaretic acid Ar = Ar5 rnachilin A Ar = At7 meso-5‘,5-dimethoxydihydroguaiareticacid Ar Ar = Arlo pregornisin Ar = Ar2 (-)-nordihydroguaiaretic acid Ary Ar = A$ (-)-dihydroguaiaretic acid Ar = Ar5 (-)-austrobailignan-5 Ar Ar = Arl (-)-3’,3”-dernethoxysecoisolariciresinol OH Ar = AP (-)-secoisolariciresinol -..,,,,OH Ar = Ar5 (-)-dihydrocubebin Ar = Ar7 5’,5”-dimethoxysecoisolariciresinol Ar Ar = Ar2l enterodiol Fig. 3 Symmetrically substituted dibenzylbutanes and dibenzyl-butanediols Ar3 A13 (-)-guaiaretic aci d (-)-dihydroguaiaretic acid A13 Ar2 mesedihydroguaiaretic acid mesenordihydroguaiaretic acid The oxidative coupling of dibenzylbutanes to give tetrahydro- dibenzocyclooctene derivatives can be achieved using a wide- variety of reagents.For example treatment 53 and 54 with NH(CH2)2Ar1 NH(CH&Arl 0 52 DDQ in trifluoroacetic acid (TFA) gives 55 and deoxyschizan- drin 56 respectively [reactions (4)and (5)].71 Oxidation with ruthenium dioxide or thaflium(rrr) oxide in a mixture of TFA TFAA and BF etherate on the other hand gives a mixture of the dibenzocyclooctene (55 or 56) and an aryltetralin (57 or 58).72 The formation of 56 is accompanied by a small amount of the isomer 59 which is taken as evidence for the involvement of a spirodienyl intermediate in the reaction.AS 7 DDQ (4) TFA AS 53 Me0 55 Me0 \ A@p;;;@ Me0 (5) AP 54 Me0 56 NMR evidence indicates that both deoxyschizandrin 56 and its isomer 59 adopt a twist-boat-chair conformation 60. Of Meopq HO more interest is the fact that two stable conformers of 55 are formed and can be isolated. However while it seems generally AP agreed that the minor conformer is the twist-boat-chair dehydroguaiaretic acid Meow Fig. 4 The guaiaretic acid family One of the few known examples of a meso-2,3-dibenzylbutanediol 51 (c$ meso-secoisolariciresinol)has been isolated from the bark of Zanthoxylum heit~ii.~~ Cannabisin G 52 which occurs in Cannabis sativa fruits is one of the more highly functionalised lignans of this type.70 APT: “$7: AP A$ 51 mesesecoisolariciresinol Ward Lignans neolignans and related compounds Me0 Me0 OMe AP OMe A@ 57 58 Me0 OMe MeO@ Me H Me0 Me0 / Me0 \ \ Me0 Me0 OMe 59 60 R1 or R2 = OMe (?Me ?Me Me0 Me0 Me0 Me Me0 Me0 OMe OMe 61 Ri =Me; R2 = H 63 62 R1 = H; R2 = Me conformer 61 in which both methyl groups are axial opinion is divided between the twist-boat conformation 62 and the die- quatorial twist-boatxhair conformer 63 for the structure of the major ~onformer.~ 1,72 Oxidation of the phenolic dibenzylbutane 64 using the ru- thenium or thallium reagent gives mainly the para-coupled prod- uct 65 with a minor amount of the corresponding ortho isomer 66 [reaction (6)].73 Oxidation of 67a and 67b using iron(II1) perchlorate affords schizandrin 68a and gomisin A 68b respect-ively [reaction (7)] along with minor amounts (20%) of the corresponding steroisomer 69.74 Similarly 70a affords iso-schizandrin 71a along with the stereoisomer 72a while 70b gives 71b and 72b along with the aryltetralin 73 [reaction (S)].75 Me0 \ TI203 or Ru02 Me0 CH2CI2 R10 (6) TFA-TFAA BF3.Et20 R20 65 R1 = Me; R2 = H 66 R1 = H; R2 = Me R20 Me6 68a R1 = R2 = Me 68b R1R2= CH2 i.Fe(CIO4)3 -+ 171 \’ I ii. KOH Ars 67a Ar=AS 67b Ar=A$ Me0 69a R1 = R2 = Me 69b R1R2=CH2 2.2 Dibenzylbutyrolactones New lignans in this series include salicifoline 74 and iso- salicifoline 75 from the leaves of Bupleurum sali~ifolium,~~ 4’-O-demethylyatein 76 from the branch wood of Thuja occidentali~,~~ the aglycones haplodocin 77 and cappodocin 48 NaturaI Product Reports Me0 Me0 71a R1 = R2 = Me 7ib ~ 1= CH~ ~2 i.Fe(C104)3 w + (8) 11. KOH A6 70a Ar=AS 70b Ar=A$ Me0 Me0 Me0 72a R1 = R2 = Me 72b R1R2=CH2 78 from Haplophyllum c~ppadocium,~~ and compounds 79 80 and 81 from Cheirolophus species,79 Taxus baccata” and Protium tenuifolium,*’ respectively. In addition isopentenyl ethers of haplomyrfolin and pluviatolide and a dihydroxy-geranyl ether of matairesinol have been isolated from Haplo-phy llum pt ilosty lum .82 A short review of naturally occurring dibenzylbutyrolac- tones isolated since 1977 has been published.84 A complete analysis of the ‘H and I3C NMR spectra of matairesinol dimethyl ether has also been published.85 73 74 salicifoline 75 isosalicifoline 76 4’-Qdemethylyatein Ark0Ark0 / / 0 0 77 haplodocin 78 cappadocin Ar = $$o OH A$ h0 / Ar5&0 Ar5ko 0 0 Ar5 79 80 81 Ar = A$ (-)-matairesinol ArA ArB Ar = Ar" buplerol (ref.86) Ar5 I Ar5 (-)-gadain (isohibalactone) (refs. 95-97) Ar = Ar5 (-)-haplomyrfolin Ar5 / Ar" isosuchilactone Ar33 Ar = Ar7 thujaplicatin methyl ether ArB Ar16 I Ar5 isoguamarol Ar 0 Ar = Ar9 (-)-thujaplicatin A14 I Ar5 isokaerophyllin (chisulactone) (refs. 86,90) A r A Ar9 I Ar3 y-thujaplicatene Ar = A6 (-)-arctigeninin Ar = Ar" (-)-dimethyl matairesinol Ar5 / Ar5 (-)-savinin (hibalactone) (refs.95,96) Ar = Ar5 (-)-kusunokinin Ar5 / Ar" jatrophan (suchilactone) Ar = Ar6 thujaplicatin trimethyl ether Ar16/ Ar5 guamarol (ref. 90) 82 Ar = Ar7 (ref. 87) Ar" I Ar5 (-)-kaerophyllin (ref. 90) Ar 83 Ar = Arlo (ref. 87) (ref. 98) Ar = Ar16 prestegane A ArA 86 Arlo I A$ (ref. 98) 87Ar"lAr" (ref. 87) Ar = Ar3 (-)-pluviatolide A6 I Ar5 nemerosin Ar = Ar" (-)-methyl pluviatolide (bursehernin) 88 Afi I A@ Ar5 x Ar = Ar5 (-)-hinokinin Ar = Ar6 (-)-yatein Ar = AP (-)-methoxy-hinokinin (dehydrotrichostin) 89 Ar3 I AS (ref. 49) Ar Ar = Arlo (-)-3'-OdemethyI-yatein (refs. 88,89) Ar5 I Ar5 dihydrotaiwanin A (ref. 99) Ar = Ar16 guarmarolin (ref. 90) Ar5 I Ar" guayadequiene (ref.86) Ar = Ar3 (-)-traxillagenin (ref. 91) Ar = Ar5 (-)-isoyatein Ar = A6 (-)-cordigerine (cubebininolide) Ar 0 Ar=Ar7 hernolactone Ar = Are (-)-cubebinone (+)-calocedrin chasnarolide methyl chasnarolide (ref. 90) Fig. 6 Unsaturated butyrolactones guayarol 5"-methoxy-yatein Ar Ar Ar = Ar16 prestegane B HO ,OMe Ar = Ar21 (-)-enterolactone gnidifolin Ar =$*OH -(-)-wikstromol (-)-epiwikstromol meridinol epimeridinol (nortrachelogenin) (epinortrachelogenin) (ref. 100) (ref. 100) Fig. 5 Dibenzylbutyrolactones A large number of dibenzylbutyrolactones are known. The parent compounds are shown in Fig. 5. Recent references are Ar3 A13 included where available but for references prior to 1990 benchequiol guayadequiol (-)-trachelogenin (-)-epitrachelogenin readers are referred to the monograph on lignans published (ref.90) (refs. 86,101) (refs. 102,103) (refs. 101,102) at that time,92 to the review published by Gottlieb and Yoshida," or to the more recent database,94 for those with access to it. A r\\\" " 3 A f\\\" l 3 A r\\\" " 3 A r\\"' " 3 As indicated above an increasing number of unsaturated lac- tones are being discovered. Previously reported examples of OH 0 OH 0 OH 0 OH 0 this type are listed in Fig. 6. Another coherent group of com- Ar" Ar" AF AF pounds are the a-hydroxy lactones such as wikstromol and tra- 90 91 92 93 chelogenin. These are compounds shown collectively in Fig. 7. Several recent syntheses involve the preparation of a,p-OH unsaturated lactones of the savinin or gadain type (Fig.7). Such compounds are readily prepared from the corres-ponding monobenzylbutyrolactone by condensation. Hydro- genation affords the cis-disubstituted lactone 94 [reaction Ar7 (9)].72Wakamatsu and co-workers have used direct oxidative hydroxythujaplicatin dihydroxythujaplicatin coupling of the unsaturated lactones 95 to give precursors for methyl ether methyl ether the asymmetric synthesis of a variety of tetrahydrodibenzo- cyclooctene derivatives (Scheme 1).'O4-Io9 OH OH Such syntheses are based upon the availability of chiral non-racemic monobenzylbutyrolactones. A new route to such compounds involves the enantioselective deprotonation of an achiral cyclobutanone 96 (X= H) (Scheme 2).96 Interestingly continuation of this scheme affords mainly the (a-unsaturated thujastandin dihydroxythujaplicatin lactone 99 which can be converted into ( -)-savinin 100 in high yield by treatment with tributyltin hydride.Fig. 7 a-Hydroxybutyrolactones Ward Lignans neolignans and related compounds 49 i. Ac20ArCHO-Ar ,’r 2 ii. LDA A iii. DBU 0 0 (Ar = AP or A@) 95 R20 Me0 I ii. ButOOH Mg MeOH R20 R10@CH20H Me0 Me0 CH20H R’o&o V,O ~30 1330 0 I R4d ~40 steps Isteps Me0 R20 Me0 ~30 R40 (-)-kadsurin R1 = R2 = R3 = R4 = Me (-)-deoxyschizandrin R’ R2 = R3R4= CH2 (-)-wuweizisu C R’ = R2 = Me; R3R4 = CH2 (-)-gomisin N R’ R2 = CH2; R3 = R4 = Me (*)-y-schizandrin Scheme 1 ci2c=c=o Ar5 3: chiral~Ar5-Ar5- Li base OSiEt3 96 X=CI 97 X=H i.O3 ii. NaBH4 Ar5 iii. H+ 0 Ar5 0 iii.~& 0 100 99 98 (80% ee) Scheme 2 50 Natural Product Reports Two other new routes for the synthesis of homochiral monobenzylbutyrolactones such as 98 have been reported. The first involves diastereoselective alkylation of the esters 101 or 102 followed by reductive removal of the chiral auxiliary and oxidative cleavage of the vinyl group [reaction (lo)].’lo The second involves enantioselective C-H insertion by a carbene [reaction (ll)].”’ /LDA 98 (86%ee) Ar5CH21 C02R2 0 98 (94% ee) Ar (Ar = Ar’ AS Ar7) R 0 H+ Me0 Me0 d’ 103 104 R’ = R2 = H 8a 12 R1 = OMe; R2 = H 50 50 R1 = R2=OMe 87 13 Scheme 3 The oxidative coupling of trans-dibenzylbutyrolactonesto tetrahydrodibenzocyclooctene derivatives is now well estab-lished but can be brought about by a wide variety of reagents.73”12,’ l3 For compounds containing a para-phenolic group the sequence using hypervalent iodine reagents gives high yields (75-87%) and can be carried out in one step (Scheme 3).'13 trans-Disubstituted butyrolactones are valuable not only as precursors for tetrahydrodibenzocyclooctene derivatives but also for a wide range of other lignan types.For example the keto lactones 105-108 which have all been prepared by tandem conjugate addition reactions provide key inter- mediates for the synthesis of lignans of the aryltetralin and furofuran type [reactions (12)-(1 5)].116117 OH 105 (R' = (-)-menthyl) NaBH4 EtOH 1 M eOMe oAr5 w TFA - \ '.*#, Me0 HO OH OH 0 106 (racemic) i L-Selectride 1;.TMSCI Et3N iii. KHMDS MoOPH I OTMS ,,/ iii. H2 Pd-C-(13) HO AP Ar' OH 0 (*)-cycloolivil 0 107 (racemic) i. L-Selectride ii. LiAIH4 1 HO 108 (R' = (+)-menthyl) LiAIH4 1 OH )/+,,. OH ;y CH20H Ar" (*)-eudesmin An alternative route to trans-2,3-dibenzylbutyrolactones, in addition to alkylation or conjugate addition involves oxidat- ive coupling of optically active acyl oxazolidinones [reaction (16)]. '* i. LDA ii. TiCI4 1 i. LiOOH A r 5 x ~ ii. Ac20 I cox' iii. NaBH4 I Ar5 Ar5 0 (-)-hinokinin cis-Disubstituted butyrolactones have been investigated less extensively than their trans-isomers.They can however be prepared by hydrogenation of a,p-unsaturated lactones as illustrated above. An alternative route to such compounds involves the diastereoselective opening of a rneso-anhydride 110 [reaction (17)].1'9 The meso-anhydride was prepared by a route involving consecutive Stobbe condensations. Doubly unsaturated lactones such as taiwanin A 111 can be prepared stereoselectively by cross-coupling of vinyl stannanes with vinyl bromides [reaction (1 8)]. '20 The vinyl 0 109 I steps '0 Ar"$ I Ar" (*)-methyl piperitol Ward Lignans neolignans and related compounds stannanes which in turn are used to prepare the vinyl *'h-Ar APb-AG OH bromides are obtained by stereoselective hydrostannation of acetylenic esters.0 OH 0 OR 120 Ar=Ar7 121 R=H 126 Ar = AP 122 R = Me Ar5yc02Me + Ar5y C02MOM Aflb-Ar5 APFj'*" EtO HO HO APhsAP SnBu3 Br OMe 0 123 124 125 0 111 127 Ar = Ar5 128 2.3 Substituted tetrahydrofurans 133 Ar =Ar3 Tetrahydrofuran derivatives are a prolific group of lignans and many new examples have been reported. Compound 112 from H4 the stems of Piper wightii,'" jacpaniculine 113 and isojacpani- Ar1C02-+ ..i-Ar7 r5yAfl culine 114 from the fruits of Jacquemontia paniculata,122 115 Ar\'I"' Ar7 !\"' 0 anolignan C 117 0 and 116 and the leaves of Ocoteaf~etus,'~~ 0 0 from Anogeissus acuminata,66 118 from the leaves of Machilus 129 130 Ar = Afl; R = H 132 japoni~a,'~~ and 119 from the leaves and stems of Piper 131 Ar = Afl; R = Me ~larkii"~are all members of the 2,5-diaryltetrahydrofuran 134 Ar=A$; R=H type.Compound 120 from the roots of Pyacantha coccinea,'26 todolactol A (=isoliovil) 121 from the heartwood of Abies marie~ii,'~~ koreanol 122 from the wood of Abies koreana,'28 busaliol 124 and busalicifol 125 from the leaves Key members of each of these series are listed in Figs. of Bupleurum sali~ifolium,~~,'~~ 126 from the wood 8-10. Once again only references later than 1990 are and of Abies pinsapo' 30 are examples of the 3,4-dibenzyltetra- included. The parent members of the lariciresinol olivil and hydrofuran category. liovil series are shown together in Fig. 11. Finally parabenzoinol 127 from the leaves of Parabenzoin tril~bum,'~' sesaminone 128 which is a metabolite of Strepto-myces species,'32 129 from the wood of Salix sachalinensis,'33 bionidin B 130 and E 131 from the flower buds of Magnolia b jondjj 134,135 132 from kernels of germinated seeds of Virola-michelii,136 and 5-hydroxylariciresinol 133 and 7-hydroxy-Ar = AP (-)-shonanin Ar = Ae (-)-brassilignan lariciresinol 134 from the wood of Abies pin~apo'~~ Ar = Ar5 (-)-dehydroxycubebin (refs.137,138,139) are members of the 2-aryl-4-benzyltetrahydrofuranfamily. AFyAr5 AB-%dAr5 Ar3A,dA$ OH HO 0 0 0 (+)-cis-b u rse ran (-) -trans-bu rse ran liovil Al.4-5 Ar = Afl (-)-kusunokinol Ar = Ar5 (-)-dihydrokusukinin do: Ar5-$ 135 Ar = Afl Ar = A6 (-)-cubebin 114 116 Ar = AB (-)-clusin '15 Me0 Ar = A$ (-)-tricostin (ref.139) A$-+ Ar = A6 (-)-cubebinin do: 0 117 118 Ar=Ar5 119 Ar=Afl Fig. 8 Key members of the 3,4-dibenzyltetrahydrofuranseries 52 Natural Product Reports Ar = Arl larreatricin (ref. 140) Ar = AP zuonin C henricine 136 Ar = Ar' (ref. 141) Ar = Ar3 3',3"-dimethoxylarreatricin (chicanine) Ar = AP nectandrin B (malabaricanol) (machilin I) Ar = Afl machilusin tetrahydrofuroguaiacin A Ar = Afl ganschisandrine Ar = Afl galgravin Ar = Ar5 zuonin A Ar = Ar5 zuonin B 137 Ar = A$ (ref. 143) Ar = Ar7 fragansin B1 Ar5 i"* \tf 0 0 Ar3 A r 0 "'IIAr A$ \$". H'IttAfl Ar!!l'~'fllA$ Ar 0 Ar Ar = A6 3-epi-austrobailignan-7 nectandrin A Ar = A$ fragansin D1 Ar = AP verrucosin Ar = Ar5 (+)-austrobailignan-7 (machilin F) (ref.142) Ar = Ar7 fragansin C1 Ar = Afl veraguensin Ar = Ar7 fragansin C3a Ar = Afl machilin G (ref. 144) (machilin H) 138 Ar = Ar5 Ar = Ar7 fragansin B3 Ar7 Ar Ar = Ar3 fragansin C3b eupobennettin Ar = AP astrolignin Ar = Arl 4-epilarreatricin (ref. 140) Ar = Afl fragansin D3 (ref. 145) Ar = Ar5 (+)-calopiptin Ar = AS fragansin A2 (ref. 144) Ar = Afl (-)-galbelgin Ar = Ar5 (-)-galbacin Ar = A$ (-)-grandisin Ar = Ar7 fragansin 82 A6 &Ar fragansin C2 demethylgrandisin 3-hydroxyd-epilarreatricin saucer netin 139 Ar = A6 tetrahydrofuroguaiacin B (ref. 140) Ar = AF fragansin D2 Fig. 9 Key members of the 2,5-diaryltetrahydrofuranseries Ar = Ar3 (+)-lariciresinol Ar = A6 (+)-lariciresinol @-methyl ether Ar = A$ (+)-acuminatin 140 Ar = Ar3 (ref.147) Ar = Afl (+)-lariciresinol Ar = Afl (+)-lariciresinol dimethyl ether Ar = Ar5 (+)-dihydrosesamin 141 Ar = Afl (ref. 147) 4"-methyl ether Ar = A$ dihydroyangambin Ar = Ar5 (+)-sanshodiol 142 Ar = Arlo (ref. 147) HOWAS HOyAF HOyAr7 Ar7 \$I" Ar2 A$\$'*' A$ \\'" ""\-IAr 0 0 0 Ar = AP (+)-5'-methoxylariciresinol (justiciresinol) taxiresinol di hydrosesartemin jusglaucinol Ar = Ar7 (+)-5',5"-dimethoxylariciresinol (ref. 148) (ref. 149) HOh:--APH9 HOh:-APHq HOwAr5Hq HOsAflHO HOwAr3 HOyAr3 .*~IIOH ..~IIOH Ar7 \I"' 0 A$ \I"' 0 Ar5 \\'" 0 Afl 0 Afl \\" 0 Ar3 \$I*. 0 143 tanegool 7-hydroxydi hydrosesamin fargesol 144 (-)-olivil (ref. 150) (ref. 150) (ref. 151) (ref. 152) (-)-berchemol 2-hydroxyolivil (-)-massoniresinol (vladinol A) (ref.153) Fig. 10 Key members of the 2-aryl-4-benzyltetrahydrofuran series Ward Lignans neolignans and related compounds (+)-lariciresinol (+)-isolariciresinol (-)-secoisolariciresinol (cyclolariciresinol) ""CH20H A13 (-)-oiivil (+)-isoolivil (cycloolivil) HO-d0H A GOH HO A 6 A13xAr3 v OH '"liAr3 0 0 0 OH neoolivil (-)-iiovii isoliovil Fig. 11 Parent members of the lariciresinol olivil and liovil series A useful review of the synthesis of tetrahydrofuran lignans has been p~b1ished.l~~ Two new syntheses of lignans of the lariciresinol'dihydrosesamin type have appeared. The first involves a straightforward reduction of a dibenzylbutyrolac- tone followed by acid-catalysed cyclisation [reaction (19)I.l 55 The second involves a radical cyclisation step which proceeds with high stereoselectivity [reaction (20)].156,'57 ILiAIH4 Ar Hol;j -" O Bu3SnH VA' AIBN Art$\" Ar (Ar = Ar5 or Ar") 2.4 2,6-Diaryl-3,7-dioxabicyclo[3.3.O]octanes New lignans in this series are 145 from Festuca argentina,I5* epimagnolin A 146 from flower buds of Magnolia fargesii,'59 demethylpiperitol 147 from leaves of Apollonias barbujana 2'-hydroxyasarinin 148 from Cuscuta chinensis,16' 6'-hydroxypiperitol 149 produced by Streptomyces species,132 crellisin A which is the diangeloyl ester of 150 from Cre-manthodium ellisii,'62 and graminones A and B 151 54 Natural Product Reports 145 146 1 47 150 153 154 and 152 from rhizomes of Imperata cylindrica.'63 In addition a hydroxyisopentenyl ether of piperitol has been isolated from the stems and leaves of Zanthoxylum pet jolare.164 Epimagnolin A 146 has been converted into the 4'- and 4"-demethyl derivatives 153 and 154 by microbial oxi-dation.'65 A full analysis of the NMR spectra of sesamolin and sesangolin has been published. 166 Fig. 12 shows the symmetrically substituted members of the furofuran series while Fig. 13 lists the known unsymmetrically substituted compounds and Fig. 14 con-tains the monohydroxy and dihydroxy derivatives. Ar = Arl ligballinol ..,,,Ar Ar = A$ (+)-pinoresinol Ar = Afl (+)-eudesmin ..kIl~ Ar = Ar5 (+)-sesamin Hi188 Ar = A$ (+)-yangambin Ar\""' 0 Ar = Ar7 (+)-syringaresinol (lirioresinol 6) Ar = A@ (+) -excelsin Ar = A9 (+)-epipinoresinoi Ar Ar = Ar" (+)-epieudesmin Ar = Ar5 (+)-episesamin (asarinin) Ar = A$ (+)-epiyangambin Ar = Ar7 (+)-episyringaresinol (lirioresinol A) Ar = A@ (+)-epiexcelsin Ar Ar = Ar" (+)-diaeudesmin Ar = Ar5 (+)-diasesamin Ar = A$ (+)-diayangambin Ar = Ar7 (+)-diasyringaresinol (lirioresinol C) Fig.12 Symmetrically substituted furofurans Pinoresinol has been synthesised by oxidative coupling of the P-keto ester 160 using potassium persulfate fol-lowed by DIBAL reduction and acid-catalysed cyclisation (Scheme 4).'73 The diketo diester 161 is obtained as a 1:l mixture with the meso isomer 162. Reduction of the latter compound followed by cyclisation gives the unnatural 2,4- diary1 isomer 164. HIIO..R..*,\A@.-OIIH HIIS...**IIHA@ A$ \\"' 0A$ \\'" 0 HI,,*.$.+\A@ .*~IIH AB 0 Hfl:fl AS 0 Ar\\I"'Hl,,a:i:r5 0 AT\'>"HI8 Ig:r5 0 (+)-sesartemin (+)-episesartemin A (+)-episesartemin B (+)-diasesartemin Ar = A$ (+)-piperit01 Ar = A$ (+)-xanthoxylol (ref. 167) Ar = Ar" (+)-methyl piperitol (kobusin spinesin) Ar = Ar" (+)-methyl xanthoxylol Ar = A$ aschantin Ardo/ Ar = A$ (+)-pluviatilol magnolin epimagnolin membrin demethyl magnolin pinoresinol (+)-phillygenol Ar = A@ (+)-methyl pluviatilol (ref. 168) monomethyl ether forsythigenol (fargesin) Ar = A$ (+)-epiaschantin (+)-medioresinol demethoxypinoresinol (+)-demethoxyexcelsin horsfieldin R = H (+)-sesaminol (justisolin) (ref. 170) (ref. 171) (5'-methoxysesamin) R = Me sesangolin 155 (+)-methoxypiperitol praderin (ref.172) Fig. 13 Unsvmmetricallv substituted furofurans Ar = AP 1-hydroxypinoresinol Ar = A14 gmelinol Ar = Ar" neogmelinol 157 (+)-fraxiresinol arboreol Ar = Ar" isogmelinol Ar = Ar5 isopaulownin Ar = Ar5 neopaulownin Ar = Ar5 paulownin Ar = Ar7 1-hydroxysyringaresinol isoarboreol epiphrymarol isophrymarol lePtostachYol Ar = A$ (-)-prinsepiol 158 Ar = A$ Me0 Ar = A6 (-)-wodeshiol Ar = Ar5 (+)-4-hydroxysesamin (kigeliol) (aptosimol) Me0 Ward Lignans neolignans and related compounds Full details of the synthesis of eudesmin and sesamin 0 by a route involving selective radical fragmentation (Scheme 5) have appeared.'74 The same method has also been applied to the synthesis of yangambin and methyl piperitol.174,175 LC02Me + Ar' MeCN Arl1 Arl 160 C02Me 0 161 i. DIBAL ii. HCI MeOH ..,,\Arl Arl lot,,. 0 0 0 K2S208 Arll $C02Me Arl 3C02Me 0 i C02Me v0 (Ar = Ar" Ar5 A$) 162 Scheme 5 i. DlBAL ii. HCI MeOH (*)-pinoresin01 c-HII-. .-IIH Art 1 \I". 8 0 163 Scheme 4 An asymmetric syntheses of (+)-sesamin and ( -)-asarinin 8:;"" HIIC-.0 following the route reported earlier involving a Heck reaction (Scheme 7) has also been rep~rted.'~~ In this case the Z-vinyl 164 Syntheses of methyl piperitol and methyl xanthoxylol and the corresponding diaxial isomer have been achieved by selective reduction of the 0-keto ester 165 (Scheme 6).'76,'77 The P-keto ester 165 itself was prepared by conjugate addition of an acyl anion equivalent to dimethyl maleate.Further reaction of the anhydrides 166 and 167 under carefully controlled conditions affords the dilac- tones 168 169 and 170 reduction of which gives the parent lignans. A variation on this strategy employing a homochiral analogue of dimethyl maleate has been used to synthesise (+)-methyl pluviatilol.17' Ar5 5 C02Me Hz Pd-C Ar5 NaHMDS or AeCHO THF -100°C C02Me L-Selectrideefc. 165 167 1 Zn(BH4)2etc. Ar5 sic 0 166 (90% de) 169 KHMDS AFCHO J iodide 171 is converted into 172 which by treatment with either a titanium or a silicon Lewis acid affords 173 or 174 which are utilised as precursors for the lignans. The radical cyclisation route utilised for the synthesis of tetrahydrofuran lignans [eqn.(20) see Section 2.31 has been extended to the synthesis of sesamin and eudesmin (Scheme 8).I8O A review of the acrobatic rearrangement reactions of furofurans which attempts to rationalise the mechanisms of many of the acid-catalysed oxidative and reductive reactions they undergo has been published.18' 2.5 Arylnaphthalene derivatives The phyllamyricins A-C (175-177) from Phyllanthus myrti-folius182and koelreuterin- 1 (178) from Koelreuteria henryi' 83 i. LiAIH4 ii. H+ ii. MsCI py H02C A+ (62% de) 170 methyl xanthoxylol (73% de) 168 methyl piperitol Scheme 6 56 Natural Product Reports OMe 0 Me0 Ar5 175 OMe 171 172 TBSOTN Ti(0Pr')~Clp I * 1 77 178 ToOa /fooo I I 174 i.NaBH4 iii. NaI04 ii. Os04,NMO iv. NaOMe I Ar5.%OH \'" 0 (61Oh ee) 1 (-)-asarinin Scheme 7 i. (COC1)2 OMSO HI~,Q:~:~ ii. TBAF 4 Ar\l'" 0 (Ar = Afl or Ar5) Scheme 8 173 179 180 i. NaBH4 iii. NaI04 ii. Os04 NMO iv. NaOMe OH I HI!,.. .-,IIH Ar5 \i'" R..""" 0 (62% ee) I (-)-sesamin R = C02Et R = CH20H i. TBSCI Et3N ii. B2H6 I 181 182 0 HO Aa OH Ar' 183 184 are listed in Figs. 16 and 17 while the conidendrin and retrodendrin series are displayed in Fig. 18. Routes for the synthesis of arylnaphthalene lignans frequently involve either the Diels-Alder reaction or Michael addition even for the synthesis of the fully aromatic compounds. Two new variations on the Diels-Alder approach are shown in Schemes 9 and 10.The first is not unusual in using an isobenzofuran as the diene but is Ar\W 0 unusual in adding the pendant aryl group at a late stage in RHcHo R = CH20TBS the ~ynthesis.''~ The second also involves an isobenzofuran but uses a Pummerer reaction to generate this component (Scheme 1 0). 90 Michael addition by an acyl anion equivalent to butenolide or methyl acrylate forms the basis for routes leading to either the nonphenolic or phenolic lignan lactones [Scheme 1 l(a) and (b)].I9l The synthesis of a wide variety of lignans utilising addition by anions of cyanohydrin silyl ethers has been reviewed.192 The twin themes of Diels-Alder reactions and Michael addition also account for most of the recent developments in the syntheses of the di- and tetra-hydronaphthalene deriva-tives such as podophyllotoxin.Jones et al. have continued to probe the stereochemical aspects of the Diels-Alder reac-ti~n.'~~ They have confirmed that addition of the a-aryl-o- quinodimethane 187 to dimethyl fumarate proceeds with exo addition adjacent to the aryl group to give 188. They also provide strong evidence to suggest that addition to dimethyl maleate also proceeds with exo selectivity to give 189 (Scheme 12). Full details of their synthesis of ( -)-podophyllotoxin from the o-quinonoid pyrone 190 involving endo addition to the menthyloxy butenolide 191 have been published [Scheme 13(~)].'~~ An alternative scheme involving an endo addition of the isobenzofuran 192 with the same dienophile leads to 57 are new arylnaphthalene lactones.The latter compound shows significant cytotoxicity against human tumour cells. Five reduced arylnaphthalene lactones have been reported. 2~-Hydroxy-4'-demethyldeoxypodophyllotoxin 179 and 4'-demethyldeoxypicropodophyllin 180 have been isolated from the stems and leaves respectively of Casearia clarkii. Todolactol B 181 has been isolated from the heartwood of Abies mariesii,127 isopolygamain 182 from Haplophyllum ptilostyl~rn,'~~'~ and hyptinin 183 from Hyptis verti~illata.''~ The aryltetralin 184 has been isolated from Larrea trident at^.^^ No attempt is made here to catalogue all of the known arylnaphthalene derived lignans. However some well known groups of compounds are displayed in Figs.15-18. Some complimentary pairs of so-called 'normal' and 'retro' lactones are shown in Fig. 15. The principal members of the justicidin series and the podophyllotoxin and peltatin group Wurd Lignans neolignans and related compounds Me0 I Ar Ar Ar5 Ar = Ar" dehydrodimethylretrodendrin Ar = Ar" dehydrodimethylconidendrin R = H diphyllin R = Me justicidin C Ar = Ar5 justicidin 6 Ar = Ar5 retrojusticidin 6 R = Me justicidin A 185 Ar = A16 (ref. 186) 186 Ar = A16 (ref. 186) 0 OR OR 0 I I I 0 I I Ar Ar Ar5 Ar = Afi chinensin Ar = A14 retrochinensin R = H taiwanin E R = H retrotaiwanin E Ar = Ar5 taiwanin C Ar = Ar5 justicidin E R = Me justicidin F R = Me justicidin D Ar = A16 dehydrodeoxypodophyllotoxin 0 OH 0 0 LO Ar5 Ar retrohelioxanthin helioxanthin Ar = Afi isodiphyllin (chinensinaphthol) Ar = A16 dehydropodophyllotoxin Fig.15 Complimentary pairs of 'normal' and 'retro' arylnaphthalene lactones OMe ?Me 0 I Ar5 justicidin A justicidin B justicidin C 0 OMe I I Ar5 Ar5 justicidin D justicidin E justicidin F Fig. 16 Principal members of the justicidin series of arylnaphthalenes OH OH I 1 0 0 A16 A16 0 (-)-podophyllotoxin (-)-epipodophyllotoxin (+)-isopodophyllotoxin (+)-epiisopodophyllotoxin (+)-picropodophyllin (Om; (OqQ 0 0 0 i \\ AS A16 O AS A16 0 AB isopicropodophyllin (-)-deoxypodophyllotoxin (-)-isodeoxypodophyllotoxin deoxypicropodophyllin isodeoxypicropodophyllin (ref.187) OH OR OMe OMe OR I Ar = Ar7 (-)-a-peltatin R = H iso-p-peltatin (-)$-peltatin A methyl ether (-)$-peltatin 6 methyl ether R = H iso-a-peltatin Ar = A16 (-)$-peltatin R = Me iso-p-peltatin (ref. 188) (ref. 188) R = Me iso-a-peltatin methyl ether methyl ether Fig. 17 Principal members of the podophyllotoxin and peltatin series of arylnaphthalene derivatives 58 Natural Product Reports 0 0 (-)-a-conidendrin D-conidendrin a-retrodendrin P-retrodendrin 0 0 Af' dimethyl-a-conidendrin dimethyl-P-conidendrin (-)-dimethyl-a-retrodendrin (-)-dimethyl-P-retrodendrin (Om0 0 0 (OmQqqI AP 0 AP O AP a-apopicropodophyllin P-apopicropodophyllin y-apopicropodophyllin Fig. 18 The conidendrin and retrodendrin series of arylnaphthalene derivatives FlI <acH(oMe)2 z [(Om] ?-r1 <Go CH2s+EtAqO CH20H 0 DPAD I Ar5 L Ar5 1 OH C02Me i.Me] NaH ii. KOH C02Me 1 (qco2H :; B2H6 CH20MOM ~ (q 11. MOMCI C02Pr' iii. ArMgCl C02Pri OMe kr DPAD = P$02C=C02Pri 1 Ar = Ar5 taiwanin C Ar = Ae chinensin Scheme 9 ( -)-isopodophyllotoxin [Scheme 13(b)].lg5 Meanwhile Charlton et al. have synthesised ( -)-deoxypodophyllotoxin by reacting the a-hydroxy-a-aryl-o-quinodimethane193 with the fumarate of methyl mandelate 194 which also proceeds endo to the adjacent aryl group [Scheme 13(~)].'~~ Michael initiated ring closure reactions have been used to prepare the isopicropodophyllone analogues 195 (Scheme 14). 97 A similar strategy has been applied to the synthesis of dihydronaphthalene derivatives such as collinusin 196b which on dehydrogenation can be converted into the fully aromatic compounds such as justicidin B (Scheme 15).19* Magnoshinin 197 has been synthesised by a tandem conjugate addition sequence (Scheme 16).'99 Treatment of podophyllotoxone 198 with base converts it initially into picropodophyllone 199 which on further base treatment yields thuriferic acid 200.200-202 Indeed it has subsequently been shown that whereas treatment of 198 with base gives 199 which is converted into 200 under acidic conditions epimerisation occurs at C-3 to give isopicropodo- phyllone 201 which on treatment with base gives epithuriferic acid 202 (Scheme 17).203 Ward Lignans neolignans and related compounds A r5 Ar5 i.Ra-Ni ii. KOSiMea (q I >I' -(OqC"" LiEt3BH 0 C02Me Ar5 AP X = H taiwanin C NaH. LiBH4 I X = OH taiwanin E justicidin E Scheme 10 Reaction of 4-bromo-4'-demethyl-4-deoxypodophyllotoxin 203 with ethanol or glycerol affords the corresponding 4-0-ethyl and 4-0-(2,3-dihydroxypropyl)derivatives 204 and 205 respectively.204 Treatment of 204 with phenyliodonium dia- cetate (PIDA) in methanol gives the quinone-methide monoketal 206 which undergoes transkelalisation by ethylene glycol to give 207. Hydrolysis of the dimethyl ketal with aqueous acid gives the corresponding o-quinone 208 (Scheme 18). 59 (4 TBSO ,CN sRl0q \ R20 MeO@ S i. LHMDS iii. ArCHO Ar Me0 Me0 Ar 0 iii.ArCHO 0 TBSO CN OTBS i. LDA ArACN ii. @CO,M~ C02Me iii. ArCHO Ar 1 95 (Ar = A+ Ar5 AS Ar7) TFAI reflux Scheme 14 TBSO CN ii. HC02Me R20 NaOMe R20 . C02Me Ar /ir R1 = R2 = Me; Ar = Ar5 diphyllin R1R2= CH2; Ar = Ar5 taiwanin E R' R2 = CH2; Ar = Afl isodiphyllin Scheme 11 Me0 Meowo Ar i. LDA ii.? I liii. AKHO Ar 1 88 0 187 C02Me E = C02Me Ar 1 89 Me0 Scheme 12 Ar 196a Ar = Afl 196b Ar=Ar5 Scheme 15 (4 Omenthyl ___ * (-)-podophyllotoxin The 4-azidopodophyllotoxin derivatives 209a and 209b AS 0 undergo a photochemical ring expansion in cyclohexene to 190 191 give the azepines 210 (Scheme 19).205In dicyclopentadiene or cyclopentene the triazenes 211 and 212 were obtained.(b) Omenthyl A number of heterocyclic analogues of lignans have been prepared. These include the fully aromatic phenolic com-(0 O 1q + Q0 --+(-)-isopodophyllotoxin pounds 21S216 prepared by Diels-Alder reactions from dimethyl acetylene dicarboxylate.206 Of greater interest are AS the diaza oxaza and thiaza analogues of podophyllotoxin 192 191 (217-219) details of which have now been p~blished.~'~-~'~ (4 pqAS +R*02cl --+(-)-deoxypodophyllotoxin 2.6 Dibenzocyclooctene derivatives 0 C02R* Eight new dibenzocyclooctene derivatives have been OH reported all of which belong to previously established series. 193 194 Thus schisantherins P and Q 220 and 221 which have been Ph isolated from seeds of Kadsura coccinea are new members of A'VH the schisantherin series (Fig.19).2'0 Kadsulignans L-N R*=\ C02Me 222-224 which were isolated from the same source are Scheme 13 new members of the kadsulignan family and differ from 60 Natural Product Reports OTBS i. LDA Ar15/jCN ii. *CO2M iii. ArISCH2Br OMe a H20H TFA ~ Me0 I= OMe Ar15 i. TsCI,Et3Niii! !gBu OMe Me0 11 OMe Ar15 197 Scheme 16 0 I1 198 0 199 1 base 0 TBSO ,CN Br OTOH 1 glycerol 0 C02Me (O&o Ar7 0 Ar15 Ar157 Ar7 0 i. TBAF Iii. LiAIH4 ?H Ar153c02Me I Ar’5 0 201 1 base 0 203 205 I EtOH OEt OEt I 1 PlDA e MeOH-0 204 0 OEt 1 e&o 0 Me0Q.. Me0go 0 0 0 207 208 Scheme 18 0 Ar 0 0 209a Ar=AS 210a Ar = A6 209b Ar=ArI7 210b Ar = Ar17 h \ N% NyJ N N T*O0 Aa 0 21 1 21 2 Scheme 19 schizandrin-wuweizisu group in Fig.24.218,219 With so many separate series established it is not surprising that some compounds have been given more than one name when isolated from different sources and that close structural relationships exist between members of different series. Some examples which illustrate these points are shown in Fig. 25. A closely related series of compounds the eupodienones are shown in Fig. 26.220 An alternative synthesis of deoxyschizandrin 56 involves reductive coupling of the diketone 228 followed by 61 . C02H 0 ‘“‘C02H Ars Aa 200 202 Scheme 17 previous members of the series in that they do not contain a cyclohexadienone unit but instead contain an oxygen bridge (Fig.20).21 ’ Indeed they could equally be regarded as members of the tetrahydrofuran series of lignans (Section 2.3). Kadsulignan L is diastereoisomeric with neokadsuranin. O-Benzoylgomisin 0 225 is a new member of the gomisin series isolated from the fruits of Schizandra chinensis.212 Since members of the gomisin series were listed in an earlier report they are not included here.213 Angeloylbinankadsurin B 226 and the corresponding acetyl derivative 227 isolated from the fruits of Kadsura japoni~a~’~ are new members of the kadsurin group (Fig. 21).215 The heteroclitins are a further series of dibenzocyclooctene derivatives shown in Fig.22,2167217 while the more well known stegane series are shown in Fig. 23 and the Ward Lignans neolignans and related compounds Ar Afl Afl 213 Ar = Afl or Ar5 214 215 OH C02Me Me0 Me0 Me0 Me0 Me0 Me0 schisantherin A schisantherin B schisantherin C schisantherin D schisantherin E (gomisin C) (gomisin B) ro\ To\ roj Me0 Me0 '%/ 0 0-angel \ schisantherin L schisantherin M schisantherin N (and acetyl) Fig. 19 The schisantherin series of hydrogenation of the C-C double bond produced [reaction (21) cf reaction (5)].221 ( -)-Steganone has been formally synthesised by a palladium-catalysed cross-coupling of an arene-chromium tricarbonyl complex with an arylboronic acid [reaction (22)].222 A number of functionalised tetra-hydrodibenzocyclooctene derivatives have been prepared starting from the corresponding a,P-unsaturated lactones which are readily prepared by oxidative coupling (cf Scheme 1).'07-'09 Some examples of the further transformations which have been carried out are shown in Scheme 20.223,224 It has been suggested that the unusual spirodienone subunit present in kadsulignans C-J may arise through cyclisation of a carbon radical derived from a methoxy group.A similar subunit is present in the heteroclitins D-F (Fig. 23) and in the interiorins A-D. Circumstantial evidence in favour of this pathway has been provided by carrying out a biomimetic radical cyclisation starting from the 2,4-dinitrophenyl ether 229 [reaction (23)].225,226 Finally an aza analogue of stegane (230) has been synthesised in optically active form by oxidative coupling of a dibenzylpiperidine derivative using VOF,.227 An aryl- benzoquinolizidine 231 was unexpectedly obtained when the 62 Natural Product Reports To\ ro Me0 Me0 HO '"I/ Me0 0 OH \ Me0 schisantherin 0 220 schisantherin P dibenzocyclooctene derivatives r0\ Lcl 221 schisantherin Q corresponding a-hydroxybenzylpiperidine was treated with RuO,.2.7 Miscellaneous lignans (-)-Padocin 232 is a lignan with a most unusual structure isolated from Hapluphyllum cappadocicum a Turkish herb.228 Formally it can be related to a 3,4-dibenzyltetrahydrofuran (Section 2.3) in which an extra cyclisation has occurred.Hydrogenation leads to cleavage of the benzylic C-0 bond to give 233 [reaction (24)]. The aryl benzocyclooctadiene 234,which has been synthe- sised by arylation of the parent benzocyclooctadiene 235,can be regarded as a bis-homo analogue of either the aryltetralin lactone or dibenzocyclooctene lignan series and as such might be expected to show interesting biological properties [reaction (25)].229No naturally occurring compounds with this structure have been reported. 3 Neolignans As in previous reports there is no shortage of new neolig- nans to include. Structures 236247 show new benzofuran 216 217 X=NH 218 X=O 219 X=S Me0 Me0 Me0 Me0 Me0 0 Me0 kadsulignan A kadsulignan B kadsulignan C kadsulignan D kadsulignan E 0 Me0 Me0 Me0 Me0 0 0 Me0 Me0 Me0 kadsulignan F kadsulignan G kadsulignans HJ kadsulignan K 222 kadsulignan L R = Pr Et Bus (heteroclitinG) rO\ Me0 \ angel = angeloyl= $ -Me0 ''P tigloyl= $-co )=\ H0 Me0 223 kadsulignan M 224 kadsulignan N Fig.20 The kadsulignan family Me0 Me0 Me0 225 Me0 LO Me0 Med Me0 (-)-kadsurin kadsuranin isokadsuranin (+)-kadsutherin (-)-kadsurarin Me0 r ro\ \ Me0 Me0 \ Me0 Me0 Me0 neokadsuranin binankadsurin A (R = H) binankadsurin B (R = H) 226 R = angeloyl 227 R=acetyl Fig. 21 The kadsurin group of dibenzocyclooctene derivatives Ward Lignans neolignans and related compounds I-? Me0 0 Me0 \ Me0 Me0 Me0 Me02C’ MeO’ heteroclitin A R = isovaleryl heteroclitin D heteroclitinE heteroclitin F heteroclitinG heteroclitin B R = angeloyl heteroclitin C R = tigloyl (kadsulignan K) Fig.22 The heteroclitins series c&o Me0 ,.P2 r$o\ Me0 $o Me0 Me0 / / ‘‘Y{ Me0 \ 0 Me0 I 0 Me0 \ 0 Me0 --Me0 Me0 Me0 Me0 R1 = R2 = H (-)-stegane R’ = R2 = H (+)-isostegane R’ = R2= H (-)-picrostegane R’ = R2 = H (+)-isopicrostegane R1R2= 0 (-)-steganone R’ R2= 0 (-)-isosteganone R1= H; R2= OH (-)-picrosteganol R1 = H; R2= OH (-)-steganol R’ = H; R2= OAc isosteganacin R’ = OH; R2= H (-)-epipicrosteganol R’ = H; R2= OAc (-)-steganacin R‘ = H; R2 = O-angel steganangin R’ = OH; R2 = H (-)-episteganol R1= OAc; R2 = H (-)-episteganacin R’ = O-angel; R2= H episteganangin Fig.23 The stegane series of dibenzocyclooctenes Me0 Me0 Me0 Me0 Me0 Me0 Me0 Me0 Me0 Me0 (+)-schizandrin (+)-isoschizandrin (+)-deoxyschizandrin y-schizandrin (-)-wuweizisu C (wuweizisu A) (wuweizisu 6) Fig. 24 The schizandrin-wuweizisu group of dibenzocyclooctenes Me0 Me0 Me0 Me0 Me0 Me0 Me0 isokadsuranin kadsuranin deoxygomisin A (-)-gomisin L2 deoxygomisin S deoxyschizandrin = deoxygomisin 0 = gomisin M methyl ether = y-schizandrin methyl ether methyl ether = gomisin K3 = gomisin N = wuweizisu B deoxygomisin U methyl ether methyl ether Fig. 25 Some Examples of overlap between the different series of dibenzocyclooctene derivatives 64 Natural Product Reports Meoq<g,,,l, .11111 <g,,lil M e O g PhCOO PhCOO .11,l1 \ \ \ Me0 Me0 Me0 Me0 I Me0 I Me0 I Me0 / Me0 I Me0 Me0 Me0 Me0 Me0 OMe OMe OMe OMe 0 OMe 0 0 0 0 eupodienone-3 eupodienone-4 eupodienone-5 eupodienone-1 eupodienone-2 PhCOO q .11111 e 0 OMe 0 0 0 0 eupodienone-6 eupodienone-7 eupodienone-8 eupodienone-9 Fig.26 The eupodienone series of dibenzocyclooctene derivatives OMe R1O \ Me0 Me0 Me0 Me0 OMe Me0 228 RIR1 = CH2; R2 = Bn TiCI4 Mg-Hg R1 =Me; R2=Bn 1 Me0 Me0 Rh(PPh&I /Et3SiH 02 PhSiHAMn(acac)z J RIO H2 -Pd-C Me0 Me0 Me0 Me0 56 Me0 Me0 i. DIBAL iii. MsCl steps ii. Os04 Ivi. LiAIH4 R1O ro 0 Me0 + d+ CHO RIO MeO$cHo CH20H Me0 Me0 Me0 Me0 “‘“$jrCH20H (CO)3C; OMe (CO)3Cr OMe OH t (-)-steganone Me0 Scheme 20 Ward Lignans neolignans and related compounds 65 Me0 Me0 229 Ar = 2,4-dinitrophenyl i.Na NH3 ii. MsCI py iii. LiAIH4 R20 R20 i. LiAIH4 ii. MsCI,py * Me0 iii. LiAIH4 Me0 Me0 Me0 Me0 Me0 R1= R2 = Me (+)-schizandrin Me0 OMe Ar5 R1R2= CH2 (+)-gomisin A 230 231 Scheme 21 Meom -H2 Meo~cH20H (24) derivatives isolated from various plant sources. The structure of schmiditin isolated from Piper schmidtii has been revised to 241b (=kadsurin B).233 Woorenogenin 242 was isolated along HO 232 A13 Pd-C HO \ 233 Ar3 with a number of glycosides in which it is the aglycone from Coptis japoni~a.~~~ p-Hydroxybenzoate esters of 248a and 248b have been isolated from Chosenia arb~tifolia,~~~ and ferulic acid esters (containing cis-and trans-ferulic acid residues boehmenans B-D) of 249a and 249b have been isolated from Ochroma lagop~s.~~~ A full analysis of the NMR spectra of eupomatenoids 3-6 and 13 has been published,239 and the Me0 MeS03H Me0 I 0 (25) absolute configuration of dehydrodiconiferyl alcohol has been established.240 HO 235 Ar4 234 _CH20H 236 237a Ar = Arl (ref.231) 238a Ar = A+ (ref. 232) 239a Ar = A+ (ref. 125) 240 (ref. 230) 237b Ar = AS (ref. 231) 238b Ar = AP (ref. 125) 239b Ar = AP (ref. 234) (ref. 233) 237c Ar = A6 (ref. 231) OMe 241a Ar = AP (ref. 234) 242 243 244 245 241 b Ar = AP (ref. 233) (ref. 235) (ref. 236) (ref. 236) (ref. 236) CH20H HocH2~..u>iAr OMe OMe OMe 246 247 248a Ar = AP (ref. 237) 249a Ar = AP (ref.238) (ref. 236) (ref. 236) 248b Ar = Ar7 (ref. 237) 249b Ar = Ar7 (ref. 238) 66 Natural Product Reports M~OTCH~OH Me10CH2OH CH20H HOq'. Ar7 OMe OH "'I A6 OHHoY5OMe A$ Ar3 250 251 252 253 Me0TcH20H (ref. 241) Me;TcH20H (ref. 242) Me;* (ref. 242) 0 NH Ar' (ref. 243) HN-Ar' H O Ar A R OH H O A6 A R OH "Ag-Ar1 AS 0 0 0 -Ar1 254a Ar = A$; R = H (ref. 244) 254b Ar = Ar7; R = OMe (ref. 244) 255a R = H (ref. 238) 255b R = OMe (ref. 238) 256 (ref. 70) 257 (ref. 70) \\ P 258 259 260 261 262 (ref. 232) (ref. 125) (ref. 236) (ref. 236) (ref. 236) 0-I ? \\ 263 264 265a Ar = A+ (ref. 246) 266 (ref. 236) (ref. 245) 265b Ar = Ar5 (ref. 246) (ref. 246) Structures 250-255 show new compounds of the alkyl aryl ether type.Ehletianol D is a glucoside of 253 isolated from Ehretia o~alifolia.~~~ p-Hydroxybenzoate esters of 2541 have been isolated from Salix sachalinensis24 and ferulic acid esters (containing cis and trans residues carolignans A-F) have been isolated from Ochroma lagopu~.~~~ Cannabisins E and F 256 and 257 isolated from the fruits of Cannabis sativa contain the 4-hydroxyphenylethylamine residues which characterise other members of this series (cf 52)." Compounds 258-266 are new neolignans of the bicyclo[3.2. lloctane type. Examples include iso-ocobullenone 264 from Ocotea b~llata~~~ and puberulins A-C 265a 265b and 266 from Piper puberul~m.~~~ Compounds 267-271 con-tain a diarylethane skeleton; nitidanin 272 from Xanthoxyhm nitidum is a further example of a benzodioxin derivative;247 isomagnolone 273 from IlZicium simonsii is a biaryl ether; and biondinin A 274 from Magnolia biondii is of a unique structural type.'35 ( -)-Viriolin 276 has been synthesised by a route involving an enzyme catalysed kinetic resolution of the acetate 275 (Scheme 22).249 Magnolol 279 has been synthesised by Ward Lignans neolignans and related compounds palladium catalysed coupling of the aryl iodide 277 and the zinc reagent 278 (Scheme 23).250 It can also be prepared by treating the dibromobiphenyl derivative 280 with allyltributy ltin .Schizotenuin D 282 the parent lignan of the schizotenuins has been synthesised from the dimethyl ester of dehydrod- iferulic acid (281) which can be readily prepared by oxidative coupling of methyl ferulate (cf Section 1.3).25' The same starting material was also used in a synthesis of 3',4-di-0-methylcedrusin 284.252Both enantiomers of 284 were pre- pared by resolving 283 on a chiral column prior to reduction (Scheme 24).An eleven step synthesis of porosin 285 has also been reported.253 This was then converted into 5-demethoxy- megaphone acetate 286 [reaction (26)]. Engler and co-workers have continued their detailed study of Lewis acid catalysed reactions of arylpropenes with quinones and have used these reactions to synthesise a number of neolignans including compounds of the kad-surenone 287 burchellin 291 and guianin (cf 292 293) type (Schemes 25 and 26).254,255 Of particular note is the subtle control which can be exercised over the outcome of such II 267 268 (ref.121) (ref. 121) 272 (ref. 247) 0 OAc OH i. NaBH4 Rhizopus- ii. Ac20 py * A+* Af'* Br Br Br 275 (79% ee) 1NaOH 276 Scheme 22 MOMO MOMO i ZnCl 277 278 DIBAL HOq AoH HOqBr Br&OH 280 Scheme 23 reactions by careful choice of the Lewis acid and the reaction conditions. A number of benzodioxin derivatives of the eusiderin type have been prepared using the general method outlined in the 68 Natural Product Reports A$& Ar5&OMe \ 3 I 269 270 271 (ref. 121) (ref. 245) (ref. 236) 273 274 (ref. 248) (ref. 135) i. Ac20 py ii DDQ/ iii. BBr3 iv. aq. NH3 OH I OMe CH20H 281 Ar=AB 283 Ar=Ar" .,,IIA+ HOCH2-y$ OMe 284 Scheme 24 MeO,,,, i.DIBAL MeO,,,. ii. MsCl * .-SIIA+ iii. Et3N H20 (26) 0 ' 0 iv. Ago py 285 286 0 i. Tf20 py ii. allylSnBu3 Pdo iii. BF3.Et20 Me.$ 287 kadsurenone (a-OMe) 289 liliflol-B 288 denudatin (P-OMe) Scheme 25 last report.256 The structure of megacerotonic acid 295 has been finally clarified by an independent synthesis by Brown and co-workers (Scheme 27).257,258 Sesquipinsapols A-C 298-300 have been isolated from the wood of Abies pinsapo,' 303261 and sesquimarocanols A and B -Ariint..hOR rnarocana.262 have been isolated from isolated from of bark &OR SnC,4 301 and 302Ehletianol C 303 has been the wood theAbies A r w / 1 equiv. + 0 (R = En) (Ar = A+ or Ar5) (R = Me or Bn) 290 R=H 291 = Me (burchellin) SOR Ar 0 I OR 292 R=H 294 (R = Me or Bn) 293 R=Me Scheme 26 HO Me Ar5CH0 piperidine i.NaOH ii. MeOH H' I Ar13CH0 Ar5 Ar'3T,yzMe * NaOMe Ar5 4. Oligomeric lignans and neolignans A number of new sesquimeric and dimeric lignans and neolig- nans have been isolated. Neoarctin B 296 and diarctigenin 297 which have been isolated from the seeds of Arctiurn lappa have very symmetrical structure^.^^^^^^^ The biphenyl link in 296 is difficult to justify on biogenetic grounds and may warrant further investigation. On the basis of the NMR data provided it would be difficult to exclude a 3"-3" link as found in 297. 296 297 Ward Lignans neolignans and related compounds of Ehretiu ov~tifolia,~~~ and simonsinol 304 has been isolated from the bark of Illicium ~imonsii.~~' Finally 305 (both erytho and threo isomers) has been isolated from the wood of Choseniu arb~tifolia,~~~ and the same compound has also been isolated from the wood of SaIix ~acha1inensi.s.~~~ Ar3-0 A-o CH20H CH20H 298 299 OMe Ar3 OH OH 300 301 CH20H 0 ""CH20H Ar3 it II OH OH OH OH 302 303 ri OHil 304 Me0 Ar'CO2CH2 I OMe 305 69 5 Hybrid lignans A new flavonolignan 306 has been isolated from the heartwood of Distemonanthus benthamian~s,~~~ while iryantherins G-J (307-310) have been isolated from the fruits of Iryanthera grandi~.~~~ Brevitaxin 311 is a diterpenelignan found in the bark of Taxus brevifolia,266 while 5'-demethoxycadensin G 312 is a new xanthonolignan isolated from Cratoxylurn cochinchi- nese.267,268Maackoline 313 is a stilbenolignan isolated from the heartwood of Maackia arnunen~is.~~~ &A Me0 OMe OMe OMe OH 306 %.,F p Arl),,,, OH A0 r / '..r 't, OH 0 A r Arl Ar' 307 Ar=Arl3 309 Ar = Ar13 308 Ar=Ar5 310 Ar = Ar5 OH CH20H 311 31 2 HO I 31 3 ( -)-Monoterpenylmagnolol 318 has been synthesised in eight steps from (+)-3,9-dibromocamphor 314.250The key step involves coupling the arylzinc reagent 315 with the iodide 316 leading to the tricyclic product 317 (Scheme 28). 6 Norlignans Ailanthondol 319 and the related 2-arylbenzofurans 320 and 321 have been isolated from Zanthoxylum ailanthoides Krame- ria grayi and K.paucifolia re~pectively.~~'-~~~ Of greater interest from a structural point of view are the pyrones 322-325 which have been isolated along with 326 from cultures A of Jamesoniella aut~mnalis.~~~biosynthetic pathway accounting for the formation of 322-325 has been proposed. The diastereoisomeric glucosides curculigine and isocur-70 Natural Product Reports MoMo? I 314 I R=H 315 R = MOM MoMo~ 1 316 1 I 4 31 8 317 R = MOM R=H NPSP = K(phenylse1eno)phthalimide Scheme 28 319 Ar=A?; R=OMe 320 321 Ar = 2-HO-CMeOphenyl; R = H HOWCO2R' HOWCO2H HO '"'C02R2 HO C02H 325 Hoqco2H HO Ar2 C02H 326 327 R=H 328 R=H 329 R=Me 330 R=Me culigine 327 and 328 and their 0-methyl ethers 329 and 330 have been isolated from Curculigo recur~ata.~~~ Ailanthoidol 319 has been synthesised from the alkyne 331 which was prepared by a palladium catalysed coupling reac- tion [reaction (27)].275 Egonol 334 and machicendiol 335 have also been prepared using a palladium catalysed coupling reaction but this time on the benzofuran 336 (Scheme 29).276 I Pdo OMe 331 OMe OMe 336 OMe 333 R=H R = TBDMS BuLi ZnClp ArSBr WPPbh OR I I I OMe OMe 335 R = TBDPS or TBDMS 334 R=THP R=H R=H Scheme 29 References 1 R.S. Ward Nat. Prod. Rep. 1993 10 1. 2 R. S. Ward Nut. Prod. Rep. 1995 12 183. 3 N. G. 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ISSN:0265-0568    

DOI:10.1039/NP9971400043

出版商:RSC    

年代:1997

数据来源: RSC