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Proceedings of the Society for Proc. SOC. Anal. Chem. Vol. 2 No. 4 Pages 41-70 Analytical C hem is tr y CONTENTS Reports of Meetings . . . . 41 Thermal Analysis Group . . 41 Annual Report of the Council.. 43 Address of Retiring President.. 55 Anniversary Dinner . . .. 61 Obituary . . .. .. . . 64 Membership changes . . . . 64 Publications Received . . . . 65 SAC Conference 1965 . . . 66 Papers accepted for The Analyst 68 Contributions from Research Workers in Universities.. 69 Notices . . .. . . . . 69 Forthcoming Meetings . . . . a0 April 1965 Vol. 2 No. 4 PROCEED1 N GS OF April 1965 THE SOCIETY FOR ANALYTICAL CHEMISTRY President of the Society A. A. Smales O.B.E. Hon. Secretary of the Society S. A. Price Hon. Treasurer of tne Society D. T. Lewis C.B Hon. Assistant Secretaries of the Society B.S. Cooper; D. W. Wilson Secretary Miss P. E. Hutchinson 14 BELGRAVE SQUARE LONDON S.W.1 Telephone BELgravia 3258 Editor J. B. Attrill Proceedings is published by The Society for Analytical Chemistry and distributed t o members and all subscribers t o The Analyst without charge Single copies may be obtained direct from the Secretary The Society for Analytical Chemistry a t the above address (NOT through Trade Agents) price 2s. 6d. post free. Remittances payable to “Society for Analytical Chemistry” MUST accompany orders tandardised an R ~ ~ ~ r n r n ~ n d e ~ s of Analysis Coinpiled arid Edited for THE ANALYTICAL METHODS COMMITTEE OF THE SOCIETY FOR ANALYTICAL CHEMISTRY by S. C. JOLT,Y R.Pharm. B.Sc. A.R.I.C. M.P.S. PP. xx+577 Price %6 6s. net Members oC the Society for Analytical Chemistry are entitled to buy copies at the special Members’ price of l 4 4s. provided they order direct from The Editor The Analyst 14 Belgrave Square London S.W.1. Remittances made out to “Society for Analytical Chcmistry” must accompany Members’ orders. Published for the Society for Analytical Chemistry W. HEFFER & SONS LTD. PETTY CURY CAMBRIDGE by

ISSN:0037-9697    

DOI:10.1039/SA96502FX012

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

70 FORTHCOMING MEETINGS [YYOC. SOC. Anal. Chem. Forthcoming Meetings May ’Tuesday 4th PRESTON Wednesday 5th BRADFORD Wednesday 19th London Wednesday 26th LONDON Friday 28th LONDON Friday 28th t o Monday 31st SCARBOROUGH NORTH OF ENGLAND SEcrIoN jointly with the North Lancashire Section of the Royal Institute of Chemistry on “Some Problems in Water Con- servation. ” Speakers F. Law B.Sc. M.I.C.E. M.I.W.E. and L. R. Bays A.R.I.C. Harris Technical College Preston ; 7.15 p.m. SOCIETY Afternoon and Evening Meeting consisting of contributions from research workers in Universities and Colleges of Advanced Technology. “Khodizonic Acid as an Analytical Reagent,” by Ii. A. Chalmers B.Sc. Ph.T>. F.K.I.C. and G. M. Telling A.1I.I.C. “The Modification of a Thermobalance to Perform Simultaneous Thermo- gravimetric and Differential Thermal Analysis,” by E.L. Charsley B.Sc. and J. P. Redfern Ph.Lj. F.R.I.C. “Studies on Inorganic Systems of Aiialytical Interest Scandium S-hydroxy- quinolates,” by T. J. Cardwell B.Sc. “S-Llbstoicheiometric Jkterminatioii of Traces of Gold by Neutron Activation Analysis,” by D. A. Bcardsley Dip.Tech. “The Synthesis of Some New Complexones and a Discussion of the Problems that Arose in the Determination of their Acid Dissociation Constants,” by M. G. Miles B.Sc. I,. I). Pettit N.Sc. M.A. D.Phil. and Professor H. 54. N. H. Irving M.A. D.Phil. D.Sc. F.R.I.C. “l~evclopment of a Spectrophotometric Method for the Iletermination of Lead in Steel TI3rass and Bronze,” by I<. M. Ilagnall M.Sc. Ph.D. T. S. West TI.Sc. Ph.D. F.R.I.C. and P. Young Dip.‘Tech.A.C.T. (Birm.). “The Polarographic Iletermination of Lead in Steels and High-temperature Alloys,” by A. G. Hamza B.Sc. and J . B. Headridge R.Sc. Ph.D. I?. R. I. c . “Rapid Automatic Coulometric Titrations,” by D. Robinson M.Sc. A.R.I.C. Bradford Institute of Technology Bradford ; 2.30 1p.m. Society Special Meeting. “Analytical Aspects of Chronopotentiometry,” by Professor J. J. Meeting Room of The Chemical Society Burlington House Piccadilly MICROCHEMICAL METHODS GROUP Discussion Meeting. “The Feathers,” Tudor Street London E.C.4; 6.30 1p.m. THERMAL ANALYSIS GROUP Inaugural Meeting. Meeting Room of The Chemical Society Burlington House Piccadilly London W.l; 6.30 p.m. NORTH OF ENGLAND SECTION Summer Meeting. Price of Wales Hotel Scarborough. Ordinary Meeting Saturday morning. “The Examination of Cosmetics,” by A. S. Beidas R.Sc. F.R.I.C. Social programme. Lingane. London W.l; 6.30 p.m. PRINTED BY W HEFFER & S O N S LTD.. CAMBRIDGE. ENGLAND.

ISSN:0037-9697    

DOI:10.1039/SA96502BX014

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

April 1965 Vol. 2 No. 4 Reports of Meetings ORDINARY MEETING AN Ordinary Meeting of the Society was held at 7 p.m. on Wednesday March 31st 1965 in the Meeting Room of the Chemical Society Burlington House London W. 1. The Chair was taken by Mr. A. G. Jones B.Sc. F.R.I.C. (Vice-President). The subject of the rnecting was “Food Analysis,” and the following papers were presented and discussed “A Rapid Method for the Estimation of Benzoic Acid in Soft Drinks,” by M. A. Ford; “The Analysis of Orange Juice,” by D. K. Lisle K.Sc,. Ph.D.; “Determination of Cyclamates in Soft Drinli-s,” by D. I. Iiees M.Sc. Ph.D. A.R.I.C. NORTH OF ENGLAND SECTION A JOIST Meeting of the Section with the Newcastle upon Tyne and North-East Coast Section of the Royal Institute of Chemistry was held at 6.30 p rn on Tuesday February 16th 1965 in the Main Lecture Theatre Rutherford College of Technology Ellison Place Newcastle upon Tyne.The Chair was taken by Mr. L. HI. W. Hallett M.A. BSc. F.C.S. F.R.I.C. The following paper was presented and discussed “Thin-layer Chromatography,” by G. R. Crunip R.Sc. A.R.I.C. SCOTTISH SECTION AN Ordinary Meeting of the Section was held at 7.15 p.m. on Friday February 26th 1965 in Room M 405 University of Strathclyde George Street Glasgow. The Chair was taken by the Chairman of the Section Mr. J. K. McLellan M.A. R.Sc. A.R.I.C. The following paper was presented and discussed “Research Work at the Government Laboratory,” by D. T. Lewis C.B. Ph.D. D.Sc. M.R.S.H. F.R.I.C. 41 42 REPORTS OF MEETINGS [Proc. Soc. Anal. Chem. WESTERN SECTION AND THIN-LAYER CHROMATOGRAPHY GROUP A JOINT one-day Symposium of the Western Section the Thin-Layer Chromatography Group and the Welsh College of Advanced Technology was held at 9.30 a.m.on Friday February 19th’ 1965 in the Pharmacy Lecture Theatre Welsh College of Advanced Technology Cathays Park Cardiff. The Chair was taken by the Chairman of the Thin-Layer Chromatography Group Dr. E. V. Truter B.Sc. A.R.C.S. D.I.C. The following papers were presented and discussed “Principles of Thin-film Chromato- graphy,” by E. V. Truter BSc. Ph.D. A.R.C.S. D.I.C. ; “Quantitative Aspects of Thin-layer Chromatography,” by L. J. Morris B.Sc. Ph.D. ; “Thin-layer Electrophoresis,” by W. J. Criddle B.Sc. Ph.D. ; “Preparative Layer Chromatography,” by H. Halpaap Dr. Rer. Nat. ; “SF Values in Thin-layer Chromatography,” by E.J. Shellard B.Pharm. Ph.D. F.P.S. F.R.I.C. ; “Thin-layer Chromatography of Steroids,” by P. J. Stevens B.Sc. A.R.I.C. In the evening following the Symposium a Discussion Meeting was held on “Thin-layer Chromatography” The Chair at this meeting was taken by the Chairman of the IVestern Section Mr. E. A. Hontoir B.Sc. A.I.M. MIDLANDS SECTION AN Ordinary Meeting of the Section was held at 7 p.m. on Tuesday February 16th 1965 a t Loughborough College of Technology Loughborough. The Chair was taken by the Vice- Chairman of the Special Techniques Group Dr. G. F. Reynolds B.Sc. F.R.I.C. M.R.S.H. The following paper was presented and discussed “Precipitation from Homogeneous Solutions,” by M. Williams B.Sc. Ph.D. A.R.I.C. MICROCHEMICAL METHODS GROUP THE twenty-first Annual General Meeting of the Group was held at 6.45 p m on Friday February 19th 1965 in the Meeting Room of the Chemical Society Burlington House London W.l.The Chair was taken by the Chairman of the Group Mr. D. UT. Wilson M.Sc. F.II.1.C. The following Officers and Committee Members were elected for the forth- coming year Chairman-Mr. R. Goulden. Vice-Chairman-Mr. T. R. F. W. Fennel]. Honorary Treaszwer-Mr. F. H. Oliver. Honorary Secretary-Mrs. D. E. Rutterworth National Chemical Laboratory Teddington Middlesex. Members of Committee-Mr. P. R. W. Baker Mr. M. P. Mendoza Mr. R. Sawyer Dr. J. H. Thompson Dr. T. S. West and Mr. D. W. Wilson. Professor R. Belclier and Mr. H. Childs were re-appointed as Honorary Auditors. The Annual General Meeting was followed by the Address of the Retiring Chairman Mr.D. W. Wilson at which the Chair was taken by the new Chairman of the Group Mr. R. Goulden 17. R. I. C. RETIRING CHAIRMAN’S ADDRESS MR. WILSON considered various aspects of microchemistry. Although it was the chemistry of small quantities he preferred to regard it primarily as a matter of technique rather than of amount. Its methods were devised when conventional methods failed to operate satisfactorily with small quantities and they were often applicable to widely differing amounts of material. Methods that were not recognised and in some instances not devised when the Microchemistry Group was started had grown in importance and had superseded some of the original techniques. Mr. Wilson thought that the confusion in developments in automatic elemental analysis was due to lack of a clear concept of what was required.There was a danger of the development of methods that were more complicated than conventional ones without being correspondingly better. There was also a danger in accepting uncritical generalisations about the quantitative value of newer instrumental methods. Although these had their undoubted place and although it was the function of the Microchemical Methods Group to keep abreast of their application a critical look should also be taken at their limitations. Mr. Wilson emphasised the role of the Group in catering for the varied needs of micro- chemists; needs that could only be fully met by a combination of discussions formal lectures arPd occasional social activities. He paid tribute to the way the Group had done this from its inception and expressed his confidence in its future. A vote of thanks to Mr. Wilson for his address and for his contributions to the Group was moved by Mr. C. Whalley B.Sc. F.R.I.C. and was passed by acclamation. Microchemistry was a rapidly changing subject.

ISSN:0037-9697    

DOI:10.1039/SA965020041b

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

April 19651 ANNUAL REPORT OF THE COUNCIL 43 Annual Report of the Council March 1965 THE success of the Programmes Committee in its selection of topics for the Society’s meetings during the year has again been in evidence. The large attendances to which reference was made in last year’s Report have been maintained and sometimes exceeded; at no meeting were less than 80 members and guests present. A major change has been made in the Group structure of the Society in the light of a report by the Committee that as was recorded last year was appointed by Council to examine the position. The Committee under the Chairmanship of Dr. A. J. Amos found that the exist- ing Group structure consisting of three major Groups each with broad and overlapping interests and a number of satellite Panels was no longer realistic if the interests and activities of the Society were to keep pace with the advances of analysis in all its aspects.The Committee recommended and Council has accepted a more flexible and dynamic structure comprising a series -and possibly a changing series-of units each directly responsible to the parent Society which would provide for the needs of specialists and ensure that the main and the subsidiary meetings of the Society between them give adequate coverage to the latest develop- ments and trends in analysis. These units-still to be known as Groups-are initially five in number Special Techniques (dealing with very new developments and older but extremely specialised techniques) Microchemical Methods Biological Methods Atomic-Absorption Spectroscopy and Thin-Layer Chromatography.The formation of further Groups in the near future is under consideration. A Group Liaison and Policy Committee has been appointed by Council the Chairman of which will be an Honorary Assistant Secretary of the Society at present Mr. D. MT Wilson. The regional organisation of the Society into Sections is being similarly examined by a Committee again under the Chairmanship of Dr. Amos; its report is expected shortly. The Proceedi?zgs of the Society which first appeared in January 1964 has now completed its first volume. This innovation makes it possible to place on record the many excellent papers read before the Society and its Groups and Sections many of which are by their nature unsuitable for The AytaZyst which remains a journal for papers describing original work.It should enable members to keep in touch with the wider aspect of the Society’s activities and to read at least in summary reports of meetings they were unable personally to attend; it records also matters of domestic interest to members. The Publications Policy Committee is anxious to increase the size and scope of the new journal which it is confidently expected will increase in stature during the coming years. l h e Council attaches great importance to the Society’s publication AnaZyticaZ Abstracts which provides a unique service to analytical chemists throughout the world. Every year sees an increase in the volume of literature to be scrutinized and to meet this situation addi- tional staff and increased accommodation have been provided. The increased accommodation for Abstracts has meant a re-organisation of the Society’s premises at 14 Belgrave Square and the Council Room has been sacrificed to form an additional office and a Committee Room.Recent meetings of Council have been held in the premises of the Society of Chemical Industry. Membership of the Society continues to increase and now stands at 2225 which is 48 more than a year ago. It was with regret that Couricil found it necessary as a result of increased administrative costs and improved services to members to make modest increases in subscriptions during the year. I t is regretted that it has not yet been possible to finalise a design €or the Society’s Medal the inauguration of which was announced last year. The coming year will be an important one for the Society. In July the SAC Conference will be held in Nottingham-a function at which accounts of original investigations in many fields of modern analytical chemistry will be presented and discussed.Arrangements are in the hands of an Executive committee and an extremely live Local Committee in Nottingham. A detailed account of the arrangements to which reference is made elsewhere in this report has already been published. He has made a special point of attending many meetings of the Groups and Sections as well as those of the parent Society. He and the Honorary Treasurer were invited to represent the Society at the Annual llleeting of the Association of Official Agricultural Chemists in Washington in October when he read a paper on the Revision of British Drug Control. He was also Chairman at the Ramsay Dinner in Glasgow.The year has been a busy one for the President Dr. D. C. Garratt. 44 ANNUAL REPORT OF THE COUNCIL jYroc. SOC. Anal. Chest. The Conference of Secretaries was this year held in November when the Honorary Secretaries of all the Groups and Sections met under the Chairmaiiship of Mr. B. S. Cooper Programmes Secretary to co-ordinate programmes for the coming year. The Council records with pleasure the announcement that Dr. L. H. N. Cooper has been made a Fellow of the Royal Society and the award of the C.B.E. to Dr. A. M. Ward Dr. S. I<. Kon and Mr. L. C. Nickolls and the O.B.E. to Mr. R. A. Wells. LONG MEMBERSHIP-The congratulations and good wishes of the Council are extended to Mr. R. H. Coysh Mr. J. R. Heather Mr. T. Manii and Dr. H. J. Stern who have completed 40 years of membership.DEATHS-The Council records with regret the deaths of the undermentioned members. It is particularly regretted that the list includes Dr. Monier-Williams (President 1945-46) Mr. Allport (Honorary Secretary 1955-6) and Dr. Lessing (Honorary Secretary 1914). N. L. Allport W. E. Green K. Lessing J . L. Campbell H. J. Hardon G. W. Monier-Williams A. Charlesworth K. F. Hayns M. Robinson F. W. Edwards J. H. St. Johnston H. M. Thompson K. Gardner J. M. Leitch SOCIETY MEETINGs-Six meetings of the Society were held during the year; the papers read and discussed were- April 1964 in London ; contributions from Research Workers in Universities and Colleges of “The Automation of Anion-exchange Chromatography of Phosphorus Anions,” by G. Niclrless Ph. D. “Kinetic Studies in Bromate Titrimetry,” by J.M. Ottaway B.Sc. “Use of Liquid Anion Exchangers in Analytical Chemistry,” by A. D. Damoclaran 1LI.Sc. “Some Applications of Thermogravimetric Analysis,” by A. W. Coats B.Sc. “The Spectrographic Determination of Beryllium in Fluorite Minerals,” by D. N. Waters M. A. I). Phil. “The Gravimetric Determination of Iron by the Homogeneous Prccipitation of Tris(2-thiopyridine- N-oxide) IronlI1,” by J. A. W. Dalziel Ph.D. D.I.C. A.R.C.S. F.R.I.C. and M. Thompson B.Sc. A.R.C.S. A.R.I.C. H. C. S. de Whalley G. L. Hutchison A. Scott-Dodd Advanced Technology and D. Rogers B.Sc. May 1964 in London on Pyrolysis - Gas Chromatography “The Identification of Polymers and Other High Molecular Weight Compounds by a Conibined “Thc Application of Pyrolysis - Gas Chromatography to the Analysis of Polymeric Materials,” by Pyrolysis - Gas Chromatographic Technique,” by C.V. Gibson H.Sc. P. E. Arnold A.R.I.C. October 1964 in London F.R.S. “Analysis in Modern lnorganic Chemistry,” by Professor I-I. J. EmclCus C. B.E. D.Sc. F.R. I.C. November 1964 in London on Toxic Substances in Air “The Significance of Maximum I’ermissible Concentrations,” by J. C. Gage B.Sc. Ph.D. F.fi.1 .C“ “Air Sampling for Industrial Hygiene,” by S. G. Luxon F.II.1.C. “The Determination of Toxic Substances in Air by Gas Chromatography,” by S. Ihminsky R.Sc. “The Conductimetric Determination of Microgram Quantities of Phosphine in Air,” by S. Greenfield “Radioactive Fall-out-Some Meteorological Aspects,” by D. H. Peirson R.Sc. F.1nst.P. “The Behaviour and Analysis of Radio-iodine a t Very Low Concentrations,” by A.E. J. Eggleton A.R.C.S. D.I.C. L.I.M. K. Perry B.Sc. and H. A. Moule B.Sc. A.R.I.C. BSc. Ph.D. A.R.C.S. D.I.C. December 1964 in London on Solvent Extraction in Analytical Chemistry “Solvent Extraction Introductory Paper,’’ by Professor H. M. N. H. Trving M.A. D.Phil. D.Sc, “Back Extraction by Addition of Organic Liquids,” by W. rvlilkowski B.Sc. (presented by J. R. “The Determination of Long-chain Fatty Acids and Surface Active Reagents in Mineral Flotation “Some Analytical Applications of Solvent Extraction in the Atomic Energy Industry,” by T. B. F.R.I.C. L.R.A.M. Price B.Sc.) Liquors,” by G. It. E. C. Gregory. Pierce H.Sc. M.A. D.Phil. April 19651 ANNUAL REPORT OF THE COUNCIL 45 February 1965 in London ; Joint Meeting organised by the Special Techniques Group with the Spectroscopy Group of the Institute of Physics and the Physical Society on New Light Sources in Spectroscopy “Analytical Applications of a Hollow Cathode Source,” by G.P. Mitchell B.Sc. and C. I. Harris. “Spectroscopic Applications of Lasers,” by T. P. Hughes B.Sc. F.1nst.P. “Spectroscopic Sources Using Microwave Excitation ’ I by E. B. hf. Steers B-Sc. Ph.D. “The Plasma Torch-Some Facts Figures and Thoughts,” by S. Greenfield L.I.M. LLI. Jones D.L.C. A.R.I.C. C. T. Berry A.R.T.C.S. A.K.I.C. and L. G. Bunch BSc. SECTIONS AND GROUPS The present membership of the Sections and Groups is- North of England Section . . . . .. .. 419 Scottish Section * . . . . . .. .. 116 Western Section . . . * .. . . .. 140 Midlands Section . . . . . . . . . . 367 Microchemical Methods Group .. . . . . 869 Special Techniques Group . . .. .. . . 1026 Biological Methods Group . . . . . . . . 355 Thin-Layer Chromatography Group .. . . 412 NORTH OF ENGLAND sEcTrox-During the year a questionnaire was circulated to mem- bers to obtain their views on the type of lecture preferred meeting place and time of meeting they desired. From the 113 replies very useful information has been correlated which will he used in the €ormation of future programmes. Atomic-Absorption Spectroscopy Group . . . . 254 Ten meetings were held and the papers presented and discussed were- Manchester January 1964 Annual General Meeting “Thin-layer Chromatography,” by G. B. Crump B.Sc. A.R.I.C. Leeds February 1964 jointly with the Leeds University Union Chemical Society “Hydrolytic Studies of Phosphorus Compounds Using Chromatographic Methods,” by F.H. I’ollard D.Sc. Ph.D. Liverpool March 1964 “The Biocheniistry of Quinones,” by Professor I<. A. Morton Ph.D. D.Sc. F.R.I.C. F.R.S. Car-lisle April 1964 jointly with the Scottish Section “Fluorine and Tooth Decay,” by Professor G. N. Jenkins M.Sc. Ph.D. “Chemical Additives in Foods,” by J . Markland R.Sc. F.R.T.C. Salford May 1964 jointly with the Microchemistry Group the Manchester and District Section of the Iioyal Institute of Chemistry and the Chemical Society of the Royal College of Advanced Technology Salford on Organic Reagents for Metals “Organic Complexing Agents as Reagents for Metals,” by F. Holmcs B.Sc. F.R.1 .C. “A Precipitant Designed for the Precipitation of Palladium,” by 1,. S. Bark R.Sc. F.R.I.C.Llandudno June 1964 Summer Meeting “The Biodegradability of Detergents,” by D. W. G. Dicker. Liverpool September 1964 “’Developments in the Analysis of Ice Cream,” by K. A. Hyde B.Sc. F.R.I.C. M.R.S.H. Leeds October 1964 jointly with the Leeds University Union Chemical Society “Some Recent Developments in Analytical Chemistry,” by H. N. Wilson F.R.I.C. Chester November 1964 jointly with the Special Techniques Group “High-resolution Mass-spectrometry,” by W. Snedden B.Sc. Ph.D. Leeds December 1964 jointly with the Special Techniques Group “Some Aspects of Polarography,” by M. L. Richardson A.C.T. A.R.I.C. 46 ANNUAL REPORT OF THE COUNCIL [Proc. SOC. Aflal. Chem. Attendances were better than last year except for the Annual General Meeting. We were pleased to welcome the President of the Society on two occasions.The two-day meeting in Aberdeen held jointly with the Microchemical Methods Group was well attended and enjoyed by all. SCOTTISH SEcTIoN-During the year seven meetings were held. The papers presented and discussed were- Glasgow January 1964 Annual General Meeting. Glasgow February 1964 “Unconventional Approaches to Qualitative Analysis,” by W. Moser B.Sc. F.R.I.C. “Qualitative Analysis of Oils and Fats by Chromatographic Methods,” by Miss 12. H. Reid L.R.I.C. Ilundee March 19634 “Organic Analytical Reagents -A Survey of Some Recent Work,” by W. I. Stephen B.Sc. Ph.D. A. lC.1 .C. Carlisle April 1964 jointly with the North of England Section 1)ctails of the payers read a t this meeting arc given in the report on the North of England Section.Aberdeen September 1964 jointly with the Microchemical Methods Group on Automatic Methods of Analysis “Nomcnclatixre,” by T. R. 17. W. Fennell 13.A. “l’rocess Gas Chromatography,” by C. S. F. Pine B.Sc. I’h. D. A.R.C.S. “Automation in Clinical Chemistry,” by C. F. M. Rose F.IC.1.C. “Diftercntial Thermal Analysis,” by B. D. Mitchell B.Sc. A.1C.I.C. Glasgow November 1964 “Some Aspects of Chemical Toxicological Analysis,” by €1. V. Street M.Sc. Ph.D. I7.K.I.C. Glasgow December 1064 jointly with the Local Sections of the Chemical Society the Royal Institute of Chemistry and the Society of Chemical Industry “The Scientific Examination of Documents,” by Professor C. L. Wilson Ph.D. D.Sc. F.I.C.I. F. IC . r . C. WESTERN s~cTIoN-During 1864 the Section has met four times including the Annual A General Meeting.three-day Symposium on “Pollution” was held in Swansea during July. Attendances have varied but on the whole have been satisfactory. The papers presented and discussed were- January IO64 Cardiff Annual General Meeting “Gas Chroma tographic Investigations of Organo-metallic Compounds of Group ZV Elements,” by I;. H. Pollard D.Sc. 1’h.D. July 1964 Swansea on Pollution “Environmental Pollution,” by D. T. Lewis C. B. L).Sc, Ph.D. M.R.S.H. F.1C.T.C. “The Effects on Industry of Recent Legislation on the Discharge of Trade Effluents to Public Sewers “Water Pollution with liespect to Sewage,” by S. H. Jenkins M.Sc.Tech. Ph.ll. U.Sc. F.Inst.S.P. “Water Pollution of All Kinds,” by L. Iclein M.Sc. Ph.D. F.K.I.C. M.1nst.S.P. “Atmosphcric Pollution,” by S. G. Burgess B.Sc.Ph.D. F. 1Z.I.C “Eftccts of Pollution on Vegetation,” by J . Wcbber. “’Biological Effects of I>ollution,” by R. 0. Brinkhurst B.Sc. Ph.D. F.1Z.E.S. “Tjdal Pollution,” by C. tZ. Pearson and I?. N. S. Chippcrfield. Water Courses and Tidal Water,” by A. 1. Biggs M.Sc. F.K.T.C. F.R. I .C. November 1964 Newport jointly with the Cardiff and District Section of the Royal Institute of Chemistry “Complexometric Methods in Analytical Chemistry,” by T. S. West D.Sc. Ph. D. F.R.I.C. December 1964 Cardiff jointly with the Cardiff and District Section of the Royal Institute of Chemistry “Thin-layer Chromatography,” by E. V. Truter R.Sc. Ph.D. A.R.C.S. D.1.C. April 19651 ANNUAL REPORT OF THE COUNCIL 47 MIDLANDS SECTION.--A questionnaire was sent out to all members in April 1964 although only about one-third of the members returned completed questionnaires.The Committee thanks those members who did complete the questionnaire which has given the Committee great assistance in arranging future programmes. EZweZZ Awavd 1964-The winner was Mr. €3. Fleet of the University of ISirmingham for his paper entitled “The Determination of Olefinic Unsaturation on the Submicro-scale.” The runner-up was Mr. D. G. Willetts of Albright & Wilson (Mfg.) Ltd. for his paper entitled “The Determination of Dialkyl and Diary1 Phosphites by High Frequency Titration.” Nine in Birmingham two in Nottingham two in Luton and one each in Coventry Ipswich Leicester and Wolverhampton. Two social functions were held during the year. Seventeen meetings were organised during the year. The papers presented and discussed were- January 1964 Wolverhampton “Couloiiietry--Principles and Progress,” by 13.Bishop B.Sc. A.R.C.S.T. F. R.T.C. February 1064 Birmingham I3rains Trust Meeting on High Purity Chemicals TXscussion initiated by It. I?. Hersant 13,l’harm. Z’h.L>. F.P.S. F.lX.1.C.’ 13. Illingworth A. R.I.C. and F. M. Idever N.Sc. Ph.D. A.K.C.S. F.I.M. F.R.1.C. February 1964 Leicester jointly with the Physical Methods Group the East Midlands Section of the Royal Institute of Chemistry and the Leicester University Chemical Society on Atomic Absorption Spectroscopy “A Brief Review of Progress in the Field of Atomic Absorption Spectroscopy,” by J. 13. Ilawson “The Chemistry of Flames,” by T. M. Sugtlen Sc.D. P.R.S. B.Sc. Ph.l>. A.1nst.P. March 1964 Birmingham Annual General Meeting “The Analysis of Peroxv Compouncts,” by C.Whalley JLSc. 1;.11.1 .C. March 1964 Birmingham “JZecent Advances in the Analytical Chemistry o f EIWA and I<elated Compounds,” by l’rofessor I). I < . Pi-ibil. March 1964 Nottingham “The Work of a Public Analyst,” by I<. A. Ijalley F.Lt.1.C. April 1964 Luton jointly with the Lea Valley Sub-Section o f the Royal Institute of Chemistry “Alnalytical Chemistry Chemical Analysis and thc Analyst,” by I<. C. Chirnsitlc F.R.T.C. May 1964 Ipswicl? jointlv with the Physical Methods Group and the East Anglia Section of the Royal Institute of Chemistry on Some Physical Methods of Moisture Determin a t’ ion “l<cvicw of Methods o f Ihtermining iMoisturc in Paper,” by I,. A. Kirk I‘l.Sc.Tech. A.M. T.Chem.E. “The Application o f Nuclear Magnetic Iiesonancc to thc Measurement of the Moisture C‘ontcnt of “An Introduction t o Microwave niloisture Measurement,” by H.13. Taylor A. M . c. 1’. Coals and Colics,” by W. I<. L,aclner 13.S~. 1%. I). A .I<. I .C. June 1064 Birmingham jointly with the I3irmingham and Midlands Section o f the Royal Institute of Chemistry the Polarographic Society and the Guild of Associates of the Birmingham College of Advanced Technology “(hlvanic Analysis,” by Dr. 1’. Tlcrsch. September 1964 I3irminghnm jointly with the I3irmingham and Midlands Section of the Royal Institute of Chemistry “The Interpretation of Ionic ISquilibria by Graphical ?Methods,” by Professor €4. Freiser and Pro- fessor Q. Fernmdo. 48 ANNUAL REPORT OF THE COUNCIL [Proc. Soc. Anal. Chef%.September 1864 Birmingham Elwell Award Meeting “The Determination of Olefinic Unsaturation on the Submicro-Scale,” by B. Fleet M.Sc. A. 1t.T.C. “Volumetric Determination of Aluminium with EDTA,” by M. A. Jenkins. “The Determination of Dialkyl and Diary1 Phosphitcs by High Frequency Titration,” by D. G. Willetts L.IL1.C. October 1964 Nottingham Discussion Meeting- “Solvent Extraction,” opened by D. Bettericlgc R.Sc. Ph.1). October 1964 Birmingham jointly with the Atomic-Absorption Spectroscopy Group on Applications and Problems of Atomic-absorption Spectroscopy “Applications and Problems in Gas Analyses,” by A. I-3. J>enshani. “The Determination of 1,ead in Gasoline and the 1)etermination of Silver,” by T. S. West €’h.I>. ““Ipplications and Problems in Agricultural Analyses by Atomic-absorption Spectroscopy,” by T.R. “The 1)etcrmination of Magnesium in Iron and Nickel Based Alloys,” by G. 7‘. P. Humphreys and D.Sc. F.K.I.C. Williams. W. I3ryson. October 1964 I3irmiiigharn jointly with the Physical Methods Group and the Thin-Layer Chromatography Group and the Birmingham and Midlands Section of the Royal Institute of Chemistry on Thin-layer Chromatography “Thin-layer Chromatography in Clinical 13iochemistry,” by J. G. Lines J?h.D. M.Sc. “Exploitation of Thin-layer Chromatography in Plant Chcniistry,” by f.3. J . Shellard B. I’harm. “Some New Techniques and Apparatus in the Field o f Thin-layer Ctirorn~ttography,” by Professor “The Use of Thin-layer Chromatography in Eiosynthctic Studies,” by H . El. Davies 13.Sc. I’h.D. ‘‘ Recent Tkvelopmcnts in Thin-layer Chromatography Equipment,” by I<.1’. Hirsch. “Choice of Media for Thin layer Chromatography,” by V. C. Weaver H.Sc. A.R.C.S. Ph.D. F.P.S. F.L.S. F.R.I.C. Ilr. Egon Stahl. A. 1Z. 1. C. October 1964 Luton jointly with the Special Techniques Group and the Lea Valley Sub- Section of the Royal Institute of Chemistry on Training of the Analytical Chemist in Physical Met hods “Coursework Training in Physical Methods in Technical Colleges,” by F. It. Williams B.Sc. F. 1t.l.C. “Unit Apparatus for the Teaching of Physical Methods of Analysis,” by A. I,. Glenn B.Sc. B.Pharm. “The Training of Analytical Chemists in Physical Methods An Industrial Viewpoint,” by A. G. I’h . I). I;. P. S. Jones B.Sc. F. I t . I .C. November 1964 Coventry “I’hotomctric Titrations,” by J. 13. Headridge B.Sc.Ph. I>. R.K. 1.C‘. December 1964 Birmingham “Experiences in U.S.A. on Boilers,’’ by D. H. Johns K.Sc. A.R. 1 .C. A.M. Lnst.17. “Principles of Control of High Pressure Boilers,” by TS. C. Potter EE.Sc. Ph.D. F.K.I.C. D.1.C. ~!~ICROCHEMICAL METHODS GROUP-Following a re-organisation of the Groups of the Society the Microchemistry Group will be known in future as the Microchemical Methods Group. Alterations to the Rules of the Group have also been made but the objects of the Group i.e. “to encourage assist and extend the ltnowledge and study of microchemical methods of analysis” remain unchanged. A %tomated Instrwnepzts for C H N Determination. Following numerous enquiries about the development of automated instruments for determining C H and N a panel has been set up which will endeavour to correlate information on these instruments and to provide for members an up-to-date picture of progress.There has been a good response to the initial circular and it is hoped that the first report will have been circulated to members by the time of the Annual General Meeting. April 19651 ANNUAL REPOKT OF THE COUNCIL 49 Three Ordinary Meetings of the Group were held during 1964. The papers presented and discussed were- London February 1964 following the Annual General Meeting “Chemical Microscopy,” by N. H. Hartshorne M.C. M.Sc. €’h.D. F.R. I .C. Salford May 1964 jointly with the North of England Section and the ltlanchester and District Section of the Royal Institute of Chemistry on Organic Reagents for Metals Details of the papers read a t this meeting are given in the report on the North of England Section.Aberdeen September 1964 jointly with the Scottish Section on Automatic Methods of Analvsis Details of the papers read a t this meeting arc given in the report on the Scottish Section. Five informal Discussion Meetings were held in London during the year and one in Aber- “‘The i\ilcasurernent and Weighing of Small Quantities,” introduced by F. H. Oliver L.R.I.C. and “The lktermination of Silicon in Organic and Inorganic Materials,” introduced by D. A. Pantony “The Analysis of Organo-metallic Compounds,” introduced by G. lngram h.1i.I.C. “The Determination o f Phosphorus Applied to Organic Inorganic and Biological Materials,” intro- “The Characterisation of Organic Compounds,” introduced by T). W. Mathieson T3.Sc. Ph.D. “ilspects of Automation of Most Use to the Microanalyst,” introduced by D.W. Wilson M.Sc. cleen. The average attendance was 40 to 45. The topics discussed were as follows- Miss J . P. Dixon F. R.I.C. T.D. B.Sc. Ph.D. F.R.I.C. P. J. Moore H.Sc. A.I<.L.C. andT. I<. F. W. Fenncll B.A. duced by 11. Q. Laws H.Sc. F.R.1.C. F.K.I.C. and 1,. C. Cross T.D. B.Sc. Ph.D. F.R.I.C. r m 1 . c . SPE~CIAI TECHNryvEs ~~ou~-Following Council’s acceptance of the Group Structure Committee’s report the Physical Methods Group will now be called the Special Techniques Group. The two subsidiary Panels of the old Physical Methods Group on Atomic-Absorption Spectroscopy and Thin-Layer chromatography are now Groups in their own right and reports on their activities are listed separately. During the past year the Group has held eight Ordinary Meetings; three were held in London and one each in Leicester Ipswich Birmingham Luton and Chester.The papers presented and discussed were- T.,ondon November 1963 Annual General Meeting “Selection of a Physical Method,” by W. Culc Davies U.Sc. Ph.D. F.R.T.C. Leicester February 1964 jointly with the Midlands Section the East Midlands Section of the Royal Institute of Chemistry and the Leicester University Chemical Society on Atomic- absorption Spectroscopy 1)ctails of the papers read at this meeting are given in the report on the Midlands Section. London March 19364 on Physical Methods Applied to the Examination of Archeological Remains “Analytical Methods in Archaeologv,” by A. I?. A. Werner M.A. M.Sc. D.Phil. “Spectrographic Methods in Archaeomctry,” by E.T. Hall M.A4. J).Phil. Ipswich May 1964 jointly with the Midlands Section and the East hnglia Section of the Royal Institute of Chemistry on Some Physical Methods of Moisture Determination Details of the papers read a t this meeting are given in the report on the Midlands Section. Lontlon July 1964 jointly with the Polarographic Society “Controlled Potential D.C. Polarography,” by L3ale J. Fisher. Birmingham October 1964 jointly with the Midlands Section and the Thin-Layer Chromato- graphy Group and the 13irmingham and Midlands Section of the Koyal Institute of Chemistry on Thin-layer Chromatography Details of the papers read a t this meeting are given in the report on the Midlands Section. 50 ANNUAL REPORT OF THE COUNCIL [Proc. SOC. A.tznl. Chefiz. Luton October 1964 jointly with the Midlands Section and the Lea Valley Sub-Section of the Royal Institute of Chemistry on Training of the Analytical Chemist in Physical Methods Details of the papers read a t this meeting are given in the report on the Midlands Section.Chester November 1964 jointly with the North of England Section Details of the paper read at this meeting are given in the report on the North of England Section. BIOLOGICAL METHODS GRow-In the year ending October 31st 1964 the Group has held in addition to the Annual General Meeting one Ordinary Meeting one Discussion Meeting and made one laboratory visit. The papers read and discussed were- December 1963 London Annual General Meeting Discussion on “The Detection of Substances with Teratogenic Properties,” introduced by K. 13. V.Spencer B.Sc. April 1964 London on Immunoassay of Horixones “Outline of Principles and Methods Available,” by Professor 1’. G. €3. (;ell M.B. R.Chir. M.R.C.S. I,. R.C.P. “Immunoassay of Chorionic Gonadotrophin,” by A. J. Fulthorpe ,M.B. I3.S. T1.T.M. & H. “lrnrnunoassay of Insulin,” by C. N. Hales M.A. M.R. IK.Chir. ATOMIC-ABSORPTION SPECTROSCOPY GROUP- As outlined in the lteport in Proceediqp August 1964 the original Atomic-Absorption Spectroscopy Discussion Panel has now been re-constituted with full Group Status. Three meetings have been organised by the Group during the past year in London Leicester and Birmingham. The papers presented and discussed were- London December 1963 A4nnual General Meeting Discussion initiated by W. Slavin. Leicester February 1964 jointly with the Midlands Section the Physical Methods Group the East Midlands Section of the Royal Institute of Chemistry and the Leicester Univer- IJniversity Society on Atomic-absorption Spectroscopy Ijetails 01 the papers read a t this mceting are given in the report on the Midlands Section LT3irminghan1 October 1964 jointly with the Midlands Section on Applications and Problenis of Atomic-absorption Spectroscopy I>etails of the papers read at this meeting are given in the report on the Midlands Section.THIN-LAYER CHROMATOGRAPHY GiiouP-The ’Thin-Layer Chromatography Group IIOW established as a separate Group held its inaugural meeting in April 1964 at the Middlesex Hospital Medical School when over 400 people were present. Two subsequent meetings have been held one at Nottingham and a Joint Meeting in Birmingham.The Group is obviouslv filling a need in providing papers discussions and exhibitions of apparatus and future meetings have been arranged accordingly in other parts of the country. The papers read and discussed were- London April 1964 “Thin Layers of Sephadex and Their Application in Chromatography and ~llcctrophoresis,” by 11. ‘Won-adhering Thin-layer Chromatography,” by R. W. 13. Edwards B.Sc. Ph.Ll. F.K. I.C. “‘Toxicological Separations,” by M. S. Moss. “The Analysis of Pesticide Residues,” by 13. Bush. “Thin-layer Chromatography of Some Synthetic Dyes,” by F. 1-i. Sutcliffe. “Thin-layer Chromatography of the Clinically Important More Polar Adrenocorticosteroids,” by A. Cameron M.B. Ch.R. F.R.C.S.E. F.K.C.S. and J. D. €1. Slater M.A. M.R. BChir. M. It.C.1’.Determann Ilr. Phil. Xst. “Thin-layer Chromatography as an Aid to the Analysis of Additives in Plastic.; ” by J. T. Davies. April 19651 ANNUAL REPORT OF THE COUNCIL 51 Nottingham September 1964 “Lipids and Related Compounds,” by I?. V. Truter 13.Sc. Pli.D. D.I.C. A.R.C.S. “The Use of Thin-layer Chromatography in Assessing Purity of Synthetic Corticosteroids,” by J. S. “Aininoacid Separations on Cellulose,” by I. Smith B.Sc. Ph.D. F.R.I.C. M.l.Biol. “Thin-layer Electrophoresis,” by J. D. I<. Thomas M.Sc. F.R.I.C. Wragg B.Sc. F.R. l.C. JZirmingham October 1964 jointly with the Midlands Section and the Special Techniques Group and the Birmingham and Midlands Section of the Royal Institute of Chemistry on Thin-layer Chromatography Details of the papers read a t this meeting are given in the report on the Midlands Section.ANALYTICAL METHODS coMMITTEE-It is now 10 years since the Committee was re- organised and the permanent secretariat was established. Among the work completed during this time was that of the Joint Committee with the Association of British Chemical Manufacturers on Trade Effluents. The methods recommended by the Joint Committee were as they become available first published in The Aqzulyst and later collected in a single volume and published in 1958 under the title “Piecommended Methods for the Analysis of Trade Effluents.” This book became out of print during the year but as the Ministry of Housing and Local Government is to include in its proposed revised edition of “Chemical Analysis as Applied to Sewage and Sewage Effluent” a section on trade effluents the intended revision of the Trade EfAuents book by the Joint Committee has been abandoned.The recommended methods for trade effluents have however been reproduced in the Committee’s “Official Standardised and Recommended Methods of Analysis.” Sales of this book which was published in 1963 have been encouraging and the publication cost has been more than recovered. The Committee is now considering the preparation of a revised edition to be published in about 4 years’ time again under the Editorship of Mr. S. C. Jolly. No new Sub-committees were formed during the year although some suggestions for new work were examined a few of which are still being actively pursued. One new Panel of the Joint Committee with the Pharmaceutical Society has been set up this being to recommend a method for determing phenothiazine.The Joint Committee realising that some of the work taken on in recent years falls outside its original terms of reference has considered and pro- visionally accepted proposals for altering these terms of reference to broaden the scope of its work. The total number of Committees Sub-Committees and Panels in existence (16) remained the same as in 1963 and the number of meetings held (52) was not appreciably greater than in the previous year (51). Considerable progress has however been made in many aspects of the work being undertaken and nine individual publications-all in The Amdyst- appeared during the year ; these were “The Determination of Water-soluble Vitamins in Compound Feeding Stuffs,” by the Vitamins (Water-soluble) I’anel of the Additives in Animal Feeding Stuffs Sub-Committee (January).“The Determination of Fat-soluble Vitamins in Diet Supplements and Cornpound Feeding Stuffs,” by the Vitamins (Fat-soluble) Panel of the Additives in Animal Feeding Stuffs Sub-committee (Ja?Zuavy). “Drying Agents for Essential Oils,” by the Essential Oils Sub-Committee (Apvil). “The Determination of Amproliuni in ,hima1 Feeding Stufis,” by the Prophylactics in Animal Feeds “The Determination of Linalol in Essential Oils Amendment,” by the Essential Oils Sub-committee “Nitrogen Factors for Liver,” by the Meat Products Sub-committee (October). “The Determination of the Capssicin Content of C,apsicum and its Preparations,” by Panel 2 of the Joint Committee with the I’harniaceuitcal Society ( J u n e ) . “The Assay of Pyrethrum,” by Panel 6 of the Joint Committee with the Pharmacetical Society (ivovembev) .“The Determination of Citronellol in the Presence of Geraniol and Linalol Studies ol a Method Based on Reactions with p-Toluenesulphonic Acid,” by D. Holness (work undertaken on behalf of the Essential Oils Sub-committee) (December). These include the Report of the Analytical Standards Sub-committee on sodium carbonate as a primary standard the Report of the Metallic Impurities in Organic Matter Sub-committee on the determination of small amounts of mercury and the Report of the Meat Products Sub- Committee on a nitrogen factor for veal; all are expected to be published during 1965. Sub-committee ( A ugust). ( A ugust) . In addition to the published work several Reports are nearing completion.52 ANNUAL REPORT OF THE COIJNCII lProc. Soc. Anal. Chenz. Miss V. Lewis who joined the staff in 1962 resigned in October. Full details of the work of the Committee and of the Sub-Committees and Panels will be published in the Committee’s separate Annual Report. outside organisations including the Parliamentary and Scientific Committee (Dr. J. H. Hamence) the Summer Schools Organising Committee of the Koyal Institute of Chemistry (Mr. C. Whalley and RiIr. U. W. Wilson) and on various Committees of the British Standards Institution. LIAISON WITH OTHER SCIENTIFIC ORGANISATIONS-The Society is represented on many In addition the following appointments have been made during the year- R.S.I. Technical Committees Mr. H. Weatherall. Mr. A. A. Christie. Joint Library Committee Chemical Society The Council expresses its thanks to all these members for their services.HONORARY TREASURER’S IiEroIzT-Members of the Society will have been informed of the Council’s decision to increase the prices of the Society’s publications and to increase sirnultaneously the annual subscription of individual members to i 4 . 0s. Od. as from January lst 1965. For many years despite a number of heavy increases in the costs of publications and consistent increases in office expenditure in Falriries in the recruitment of additional personnel etc. the Council of the Society has strongly resisted any move to place the burden of these additional expenses on our members or on the purchasers o f oiir publications. So unceasing however have been the heavy financial pressures on the Society in more recent years that the Council has a t last reluctantly decided that it is in the best interests of all that the recommendations of the Finance Committee regarding future increases in the Society’s financial charges be implemented immediately.During 1964 our solicitors Messrs. Alsop Stevens and Beck made application to the Commissioners for tlie re-registration of the Society under the Charities Act 1960 the Analv- tical Methods Trust being included as a subsidiary trust of the parent Society. This has now been effected. The Commissioners will require a return to be made o f the Society’s financial transactions once in every five years. Investments or sales of stocks held by the Society have continued to be made under the advice of our brokers Messrs. Chance Cyr Co.The position of our holdings is generally satisfac- tory although the recent autumnal fluctuations on the Stock Exchange have naturally affected the market value of many holdings. The Society’s financial position is quite satisfactory and the recent measures taken by Council should improve matters during the next few years. The Society’s auditors Messrs. Kidley lir Co. h a w carried out an audit of the Society’s affairs and provided a balance sheet to October 31st 1964. A4rrangements have been agreed with our publkhers Messrs. M’. Heffer & Sons for the publication of the Decennial Index of Analytical Abstracts in 1965. The cost of this venture will be around Ll5,OOO and will considerably deplete those reserves which have been set aside for such activities. Council reels however that there is a pressing international need for such an index of analytical researches and it is believed that this publication will be well received by analytical laboratories and institutions all over the world.The Council of the Society have approved the funds necessary for the production by the Royal Mint of the Society’s Gold Medal. Unfortunately despite several approaches to various designers and a general approach to members of the Society no suitable design has yet been received. PROGRAMMES COMMITTEE-The general pattern of programme established during tlie preceding two years has continued. All the meetings of the Society during the past session listed elsewhere in this Report were held in London and were well attended. As in the previous year one meeting (April 1964) was devoted to contributions from Research Workers in Universities and Colleges of Advanced Technology.It is planned to hold a further meeting of this type in May 1965 in Bradford. The meeting in February 1965 on “New Spectro- scopic Light Sources” was organised for the Society by the Special Techniques Group; this meeting was held jointly with the Spectroscopy Group of the Institute of Physics and the Physical Society. Dr. J. G. A. Griffiths A special Committee has been set up by Council to advise on this matter. April 19651 ANNUAL REPORT OF THE COUNCIL 53 Over seventy papers have now been entered for the SAC Conference 1965 at Nottingham. The refereeing of the complete papers is the responsibility of The A~lalyst Editorial Committee ; the Programmes Committee is undertaking the planning of the scientific sessions and other arrangements in connection with the presentation of papers and the recording of the dis- cussions.A Sub-committee has now been formed in order to organise the Conference on Particle Size Analysis planned for 1966 a brief reference to which was made in last year’s Report. This Sub-Committee is under the Chairmanship of Nlr. E. Q. Laws with Mr. I>. C. Soul as Honorary Secretary. This Conference will be held at Loughborough College of Technology probably in September 1966. THE ANAI,YsT-’rhe 1964 volume of The ANalyst has been devoted in its entirety to the publication of scientific information and the appraisal of analytical techniques and of books. The ancilliary information that used to appear in this journal has been published in the new Pvoceedings.This re-orientation has permitted an effort to be made towards giving a broader coverage of scientific matter of interest to analysts. It has inevitably resulted in a slight decrease in the size of the volume to 814 pages. The volume contains 137 Original or Review Papers 9 Reports prepared by or on behalf of various Sub-Committees of the Analy- tical Methods Committee and 103 book reviews. The introduction of summaries in a form suitable for incorporation into card-indexes has been favourably received. The audited circulation (regular subscriptions) for 1964 was 7161 compared with 691 2 for 1963; to allow for casual sales 7500 copies of each issue were printed and this has been increased to 7750 for the current year (1965). The editorial staff of The Analyst which is also responsible for the Pmxediqags has been augmented during the year by an additional editorial assistant Mrs.S. M. McArthur. PROCEEDINGS OF THE SOCIETY FOR ANALYTICAL CHEMISTRY-The first volume of the new monthly journal recording the activities of the Society has been completed and consists of 142 pages. In it have been published statements of policy particularly in respect of the new Group Structure of the Society and the Annual Keports of the Council and the Analytical Methods Committee as well as formal reports of meetings and summaries of 41 papers pre- sented at those meetings. It also contains items of a more routine nature such as news of changes in the Society’s membership notices of forthcoming meetings of other organisations and information on publications that might be of interest to analysts.An innovation lras been the chronological listing of the forthcoming meetings of the Society and its constituent Sections and Groups on the back cover which can be detached from the journal and pinned to a notice board for publicity purposes. Some issues particularly at the beginning of the year and again in the late summer have been small; Volume 2 will not only be larger but should also be more evenly balanced from month to month. ANALYTICAL AI~sTRrZcTs-r~he number of abstracts published in. 1964 was 5835 (on 764 pages) compared with 5503 (on 720 pages) in 1 963 ; and was the highest in any one year since the inception of Analytical Abstvacts; the previous record was 5564 abstracts in 1962. In spite of this increase in numbers there is still a long delay between the publication of an original paper and its abstract but by being more selective in the choice of material to be published and by having the additional staff authorised last year it is hoped that this delay will be reduced.Sales have continued to rise the audited figure €or the monthly circulation for 1964 being 7956 copies compared with 7689 copies for 1963. Good progress is being made with the compilation of the Decennial Index by Dr. K. Evers and Mrs. E. M. Hulslten who are preparing respectively the Subject and Author sections. There have been several changes in the constitution of the Abstracts Committee during the year. Mr. K. S. Cooper Chairman of the Committee from August 1962 resigned after his appointment as the Society’s Programmes Secretary and was succeeded by Mr.A. G. Jones. Dr. J. E. Page was co-opted as a member to deal with the physical methods section of Anal-ytical A hstracts formerly covered by Mr. Cooper and Dr. H. J . Cluley was co-opted as an additional member to help with the inorganic field. 54 ANNUAL REPORT OF THE COUNCII [Proc. SOC. Anal. Chem. PURI,ICATIONS POLICY COMMITTEE-Growth in the services offered by the Society to its members together with increased printing and distributive costs associated with the Society’s publications has inevitably been accompanied by increased administrative costs. Con- sequently it became necessary during the early part of the year for the Committee to review the policy regarding members’ entitlements to journals and to consider very carefully the whole question of the cost of publications.As a result of these deliberations the Committee felt bound to recommend to the Finance Committee that certain increases in subscriptions should be made both for ordinary members and to outside subscribers. These recommenda- tions were endorsed by the Finance Committee and subsequently approved by Council and will take effect from the beginning of 1966. Arrangements have been made for the publication of a Decennial Index for Analytical Abstracts by Messrs. W. Heffer & Sons and it is hoped that the substantial financial outlay that this venture will entail will be more than off-set by a brisk demand for the Index from a large proportion of the subscribers to Abstracts. Volume 1 of the Society’s Proceedings has now been completed; it is the Committee’s intention that this should increase in stature in the years ahead and give a broad coverage to the reporting of meetings of Groups and Sections as well as of the parent Society and become the vehicle for news items and information of interest to members.The Committee has also been concerned with the question of giving increased publicity to the Society’s activities particularly in the Universities and Technical Colleges and active steps are being taken to keep them informed about meetings. (;IWUP LIAISON AND POLICY COMMITTEE -This Committee was formed during the year under the Chairmanship of Mr. D. W. Wilson following Council’s acceptance of the new Group structure. The Committee consists of the Chairman of all the Groups two members appointed by Council the Chairman of the Programmes Committee and the Honorary Officers of the Society. So far the Committee has only met once when the following terms of reference were agreed (a) To co-ordinate the activities of the Groups. (b) To act as a liaison between the Groups and Council. (c) To keep under constant review the need for new or the discontinuance of existing Groups. I>. C. GAKKA’TT President. S. A. PRICE Honorary Secretarj..

ISSN:0037-9697    

DOI:10.1039/SA9650200043

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

April 19653 ADDRESS OF THE RETIRING PRESIDENT 55 Address of the Retiring President D. C. GRRRATT Ph.D. D.Sc. F.R.I.C. Hon. N.P.S. (Delivered after the Anmwal General Meeting March 5th 1965) The Analyst in Pharmaceutical Industry THE analytical problems facing the pharmaceutical industry are mainly due to the hetero- geneity of the chemicals-mainly organic-which have pharmacological action the variety of materials used to incorporate the drugs in a form suitable for administration and the rapid change in the pattern of prescribing. Many drugs in common use are described and standards for their quality specified in either the British Pharmacopoeia or the British Pharmaceutical Codex and one only has to compare the monographs for each succeeding edition of either of these books to realise the changes that have taken place.However there are still many drugs marketed which have not been included in these official publications either because they are new and must wait for the next editions or because the claims for their therapeutic value have not been proved. Earlier pharmacy had to rely on drugs of natural origin most of which have gone out of use because of their relative toxicity compared with their therapeutic value; many could not justify any claim of therapeutic value. That was the age of polypharmacy where complex formulations were prescribed where “a little bit of every- thing might do you good.” The claims for many earlier chemotherapeutic agents were based on flimsy pharmacological evidence; some even have definite toxic properties and most of these natural products and earlier synthetic drugs have been replaced by synthetic chemicals of more specific action low toxicity and higher potency.The more obsolescent drugs tend to be retained in proprietary domestic remedies where the manufacturer is reluctant to change the established formula. However the dose given is generally relatively low so any possible harmful qualities are unlikely to cause serious effects. The skill of the analyst of the early days was no mean accomplishment and considerable experience was needed to standardise such preparations as those of opium cinchona aconite nux vomica or belladonna. It is interesting to note the amount of standardising that was done in earlier pharmacopoeias. For example in the 1864 edition-just 100 years ago- the monograph on Arsenical Solution requires that “441.5 grains by weight (1 fluid ounce) boiled for five minutes with ten grains of bicarbonate of soda and when cold diluted with six fluid ounces of water to which a little mucilage of starch has been added does notgive with the volumetric solution of iodine a permanent blue colour until 808 grain-measures have been added; corresponding to 4 grains of arsenious acid in one fluid once.” The volumetric solution of iodine contained 127 grains of iodine with 180 grains of potassium iodide in 10,000 grain-measures.The present official Arsenical Solution is standardised in exactly the same way. However for Eicarbonate of Potash the assay read “Fifty grains exposed to a low red heat leave thirty-four and a half grains of a white residue which requires for exact saturation 500 grain-measures of the volumetric solution of oxalic acid” and the analyst was left high and dry-he was not told how to assess “saturation.” The pattern of prescribing has changed rapidly and the modern medicine is usually in a single-dosage form such as a tablet capsule or injection and since the drugs are generally more potent than those used formerly the dose is small and has to be diluted with physio- logically inert material to bring the bulk up to a manageable size for easy handling.However with simplification of formulation other problems have arisen particularly in the pharma- ceutics associated with low-dosage forms. Although a few drugs fall into groups related both in chemical structure and pharmacological activity-such as barbitones sulphonamides and steroids-the drugs being introduced at present are generally very complex organic chemicals o f such variety that is has been quite impossible to devise specific assays for more than a fraction of them.For most the pattern of control has had to be suitable identity tests coupled with limit tests for chloride sulphate ash and metals to show adequate purification and a non-specific assay. In chemicals where a specific impurity is known to occur a limit test can be imposed. An interesting example of this is in the monograph on aspirin where for several editions of the B.P. a stringent limit of free salicylic acid has been imposed in this case with very little pharmacological justification. 56 ADDRESS OF THE RETIRING PRESIDENT [Proc. SOC. Anal. Ckzem Yet even this pattern of specification is changing which is partly due to the influence of tlie Committee on the Safety of Drugs recently set up to advise on the marketing of new drugs and also to the appreciation by analysts that the specification designed to show the “purity” of a drug is of less value than one able to detect and determine the impurities present whether these are of greater toxicity or not.For example many drugs could meet their present specifications when containing a large proportion of an isomeric compound of no therapeutic value. An important consequence of devising sensitive methods of test for specific impurities is that the quality as well as the quantitative determination of drugs made u p in dosage forms can be controlled. If a very impure drug is used in low dosage in a preparation the present official specifications do little to prohibit its use or detect its presence.PREPARATION OF SPECIFICATIONS- The preparation of the official specifications for medicinal chemicals and their formulated products in the R.P. and R.P.C. is a task of considerable magnitude and requires the voluntary co-operation of a number of senior members of technical staffs in the pharmaceutical industry. Without this co-operation the publication would be well-nigh impossible. When a drug which comes on to the market is found to be of sufficient value and importance the Rritish Pharmacopoeia Commission working under the authority of the General Medical Council will staridardise its quality by preparation of a monograph. Standardisation of drugs of lesser importance is similarly done by the Codex Revision Committee although the value oE this publication is particularly for the standardisation of the more complex pharmaceutical formulations.Generally one of the manufacturers of the substance will be asked to submit control methods which will include impurity limits and standards-these draft specifications usually include identity tests physical constants and a chemical assay together with quanti- tative tests to limit likely impurities especially of an undesirable nature. This information is usually first examined by an analytical committee drawn from experts in various fields of pharmaceutical analysis and may then be passed to a second committee to deal with other aspects of the specification such as formulation and sterility testing. Members of the analytical committees which include representatives of the laboratories of the Commission or the Codex and generally a member from the Government Laboratory critically examine the proposed monograph against a sample of the inaterial and report their findings.Often much analytical research is undertaken to make tlie methods acceptable and the adopted standards are as strict as possible bearing in mind a realistic appreciation o f the manufacturing problems. There has been frequent criticism of the methods of the R.P. and R.P.C. in my opinion unjustifiable in most cases and often due to the inexperience of the critic. It is always difficult to decide how much detail should be given in the description of the methods since it is not possible to anticipate the experience oi the various analysts who \vould be using them.This is particularly true when the active constituent has to be extracted from a natural product or a formulated preparation. Although the tests are examined critically with normal pharmaceutical materials no allowance is possible for the effect of newer indus- trial materials in formulation hencc there is some reason for allowing discretion by the analyst for any modification of the procedure. The accepted standards which form the monographs in the official publications are reviewed with each revision that is every 5 years and where possible more up-to-date methods substituted. I t can be expected that revision of any method will either reduce the time for analysis or more impostant give greater specificity to the method. The tolerances allowed in the proportion of active ingredients in official specifications for formulated products are based on an allowance for the variation in composition in manufacture tlie lowest permissible quality of the drug incorporated and the errors of determination.Thus the main consideration for the standard imposed is mainten- ance of good pharmaceutical practice. ANALYTICAL CONTROL METHODS- The newer techniques available to analysts have revolutionised the methods of analysis €or controlling medicinal products. In my opinion the use of EDTA titrations the flask combustion technique and flame photometry (with atomic absorption) have had a greater impact on quantitative pharmaceutical analysis in the last few years than all other improve- ments altogether. The sensitivity of paper and thin-layer chromatography has shown that many so-called pure drugs may contain small amounts of contaminants some of which are of undetermined toxicity and incidentally these methods have shown that organic chemicals April 19651 ADDRESS OF THE RETIRING PRESIDENT 57 are more difficult to purify than was previously believed.However British chemical reference substances of a high degree of purity are now being introduced for comparison assays; as well as thin-layer chromatography and paper-chromatography column and gas - liquid chromatography and phase solubility have all been used to establish the purity of these compounds. Generally ultraviolet absorption infrared absorption ultraviolet fluorescence and polarography have not been of great help in detection or determination of small amounts of impurities in synthetic medicinal chemicals but rather have found important use in quantitative assay work ; all offer considerable advantages of speed in routine analysis.Nuclear magnetic resonance has proved of value in confirmation of isomerism. Although inorganic chemicals are of considerably less importance in pharmaceutical practice in the inorganic field flame photometry and atomic-absorption spectroscopy have fully justified their replacement of classical quantitative analysis. EDTA titration does however compete with instrumental methods in certain circumstances. For instance some laboratories have to carry out repetitive assays of antacid mixtures such as combinations of calcium magnesium bismuth and aluminium salts; here the chemical method is quicker. As far as I am aware no modern technique has originated from the needs of pharma- ceutical analysis but it is surprising the number that have been adapted for this purpose and there is hardly one which does not find a use.In the adaptation much ingenuity has had to be used since the materials under test are usually very complex the medicament which is being determined often being diluted with heterogeneous materials which by their nature and use are intended to cause emulsification and resist separation; further the amount of drug is often quite small in relation to the finished product. Many reactions especially formation of colour complexes specific to chemical groupings have been used for the determina- tion of small amounts of drugs in formulations and much credit is due to pharmaceutical analysts for their researches into these methods to put them on a satisfactory basis and for investigating the factors which affect their accuracy.Recently published investigations in methods of this type which might be mentioned have been the use of 2,3,5-triphenyltetr- azoliurn chloride for the assay of 17,21-dihydroxy-20-oxosteroids the 4-aminophenazone method for phenolic substances and the iodic acid - nickel chloride colorimetric method for morphine. Although for speed and precision the pharmaceutical analyst prefers to use either chemical or physical methods it is necessary in his control of some products to use both biological and micro-biological techniques. Biological assay is required for control of the various insulin injections trophic hormones digitalis and many other purified natural products of indefinite composition.Microbiological assay is needed for many antibiotics isolated from mould cultures particularly when present in formulations only in low concentrations ; many prepara- tions containing vitamins are also assayed microbiologically. Much work has gone into analytical research to replace the biological tests which are usually expensive and time consuming. A paper-chromatographic technique can now be used to determine insulin in injection solutions instead of the lengthy mouse or rabbit test although for T.S.A. require- ments the chemical method is not recognised. Many antibiotics once assayed by- micro- microbiological methods are now determined chemically. Apart from their use for assay purposes microbiological and biological methods are also required for other control testing particularly for sterility testing and testing for absence of pyrogenicity in injection material.The pharmaceutical analyst should have had experience in this field to be able to appreciate the significance of the findings. Strict control of packaging materials such as bottles metal tubes and caps and rubber components is required for modern methods of manufacture and filling. Control methods are becoming more complex and exacting with the rapid rise in the use of plastic containers closures and components for aerosol packs. Earlier control of these plastic products was limited to physical measurements of dimensions and simple performance tests but with expri- ence of failure of components during use more assessment of the chemical nature of the plastics is being undertaken to provide a specification so that a uniform quality of container is maintained.However laboratory samples may not be representative of the bulk delivery and visual inspection of a new consignment by trained personnel is an essential part of pharmaceutical packaging control. A pharmaceutical company having overseas trade has an added problem of controlling foreign depdt stocks and the responsibility for any manufacture undertaken by subsidiary companies. It is often the control staff of the parent company who must assess and approve 58 ADDRESS OF THE RETIRING PRESIDENT [Proc. Soc. AnaE. Chem. these products made in other countries; here judgment is required both in maintaining the standard expected for the parent Company’s product while permitting the use of local materials for production-of course the general standard of merchandise in the country in question must also be a guiding factor.STA4NDARDS AND TOLERANCES- Apparent discrepancies in pharmaceutical specifications for the basic drugs need some explanation. As already mentioned most drugs are complex synthetic organic compounds and even allowing for small amounts of impurities being present such as inorganic matter moisture solvent left after crystallisation intermediates and analogues the minimum purity figure often 99 per cent. or 98.5 per cent. might not be the true answer. In many cases it reflects the difficulties of assay. Evidence is accumulating that many assays in the organic field are not so capable of the accuracy formerly ascribed to them as to justify the tight standards that are imposed.Now pharmaceutical analysts working on collaborative tests and inter-laboratory trials in the preparation of monographs on medicinal chemicals have accepted the unpleasant fact that there are many sources of errors yet to be uncovered. They have realised that differences of results may arise from small differences in technique even within the same laboratory; errors of observation and many other factors now being recognised as inherent to even precise analytical methodology are being brought to notice by collaborative trials and detailed analyti- cal research. Who would have anticipated that a Grade A works-certified burette in constant use over 2 years with N alkali could have developed an error of 0.6 per cent. from the solvent action of the reagent? This has been recently brought to light in a large laboratory where the trustworthiness of the personnel responsible for standardising volumetric solutions was questioned-the molarity seemed to be constantly changing; the work is to be published shortly.Some doubt is being cast on the presumed accuracy of physical methods since collaborative studies have shown the effects of instrumental variation-particularly between laboratories-to be much greater than was previously believed. A trial showed that for a simple determination of a pure chemical against a reference sample by ultraviolet absorption differences of up to 1.6 per cent. were possible between two determinations on one instrument and up to 4.2 per cent. variation between laboratories. The Analytical Standards Sub- Committee of the Society’s Analytical Methods Committee in their collaborative determina- tion of the purity of sodium carbonate as a standard had to standardise details of the directions of procedure to an exceptional extent to acquire the accuracy they attained.The tolerances permitted on formulated products may seem unnecessarily wide with JO per cent. variation allowed for the active ingredient present in small dosage forms and as much as 5 per cent. where quite large quantities of drug are present in the preparation. These wide tolerances are mainly allowances for pharmaceutical manufacture since allowance must be made for extemporaneous preparation in a pharmacy dispensary although most firms work within much narrower limits; again difficulties of analysis must be accepted and allowed for especially if microbiological assay has to be used.Any proposals for narrowing the tolerances should be considered cautiously. A reason for narrowing the tolerances is to make the practice of manufacturing to the lowest permissible limit of content in order to save the manufacturer expense less attractive-it is doubtful whether this is done; to attempt medical justification is in most cases untenable since the sensitivity of response of the human body is not normally sufficient to detect such differences in the administered dose. If or when the l3.P. and R.P.C. standards become legal requirements (which may arise if the Ministry of Health’s intention to assume responsibility for their publication comes about) it may be necessary to prohibit formulating products with materials which interfere with the official method of determination since for legal purposes it is not possible to allow variation in assay procedure and it may be necessary to stipulate as is required by the United States Pharmacopoeia that “unless otherwise specified in the individual monograph suitable sub- stances may be added to a pharmacopeial article or preparation to enhance its permanency or usefulness.Such substances may be regarded as suitable only if they . . . do not interfere with . . . the tests and assays prescribed.” This would be a distinct departure from present practice in which it has always been accepted as a principle that it is wrong to discourage technical advance in formulation for the convenience of the analyst. It is known that certain formulations do not give accurate assays of the medicament because of interference of the other ingredients present-usually incomplete extraction of the drug results.To modify April 19651 ADDRESS OF THE RETIRING PRESIDENT 59 the method of assay to overcome these difficulties presents no great problem to the experienced pliarmaceutical analyst but with the continuous introduction of new formulating materials it is unwise to expect the official assay or specification invariably to give the correct answer which in many instances without suitable modification it will not and may lead to an error of judgement on the quality of a product. The analyst must learn a considerable amount about the intricacies of methods of pharmaceutical production. Small departures from normal manufacturing technique or use of raw materials slightly off specification can affect the finished product the effect only being noticed long after packaging.Breaking of emulsions hardening of tablets discoloration of creams and precipitation in normally clear solutions are obvious manifestations. Other pharmaceutical know-how has also to be acquired such as a knowledge of the drug laws if the control analyst is to cover his duties adequately and accept the responsibility of assuring that all the products of his company on the market are beyond reproach. Quality control in the pharmaceutical field should not be thought to be confined to analytical examinations in the laboratory. “Good housekeeping” in the production depart- ments is essential with adequate supervision by qualified pharmacists. Clealiness must be maintained and accidental Contamination avoided.This is particularly necessary where aseptic filling of injections is undertaken since subsequent tests for sterility of the filled pro- duct can only be designed on the basis of a probability of freedom from undue contamination. However the control laboratory should carry out microbiological surveys of all factory areas whether aseptic conditions pertain or not in order to track dovlin and eliminate sources of contamination since many products may suffer deterioration-especially by fermentation- if made in bacteriologically dirty areas. Research in the field of pharmaceutical quality control is necessary in two directions. Firstly with the growing realisation of the need to revise the design for specifications of drugs it is desirable to look afresh at the now well established drugs to ascertain whether there is an impurity pattern and if so to provide methods and limits for the impurities.There is also a need for more specific identity tests and methods for assaying medicinal cliemicals parti- cularly with the marketing of drugs of closely similar chemical composition but different pharmacological activity or action two or more sometimes being formulated together ; these methods should be capable of differentiating between the drugs under examination and their decomposition products. The rapid widening in the scope of tlie Society’s activities reflects the multiplicity of techniques which are being harnessed for tlie use of the analyst in commerce; the position he has attained compares favourably with that of other branches of scientific and technical work.With his increased armoury his analysis can be more searching and only he can interpret the results to make the fullest use of them. With increased use of analysis pharmaceutical control laboratories are becoming larger and many analysts find themselves responsible for a considerable overhead in a Company’s production costs and must therefore appreciate the need for good laboratory organisation and high efficiency. To be of greatest service to his employers an analyst must always relate his departmental activities to the commercial needs. TRAINING FOR ANALYSTS- The pharmaceutical industry is being faced with the need for two distinct classes of analyst in the senior positions. One is required to have a general knowledge of all the fields of analysis which are involved in pharmaceutical control he is the man who must adjudicate on the quality of a product and by the very nature of his experience does assume the responsibility and has the administrative functions-such is the chief analyst; the other must have good specialised knowledge in one discipline such as instrumentation microbiology bio-assay packaging and even specialisation within a discipline is desirable.Although the monetary reward is generally higher for the chief analyst the value of the specialist is becoming more apparent and his salary is not far below that of the other. A specialist analyst must be avail- able to those firms producing new drugs since as has already been said the climate of opinion in the drug field now calls for a searching assessment of the purity of the chemical under investigation as well as its pliarmacological action and therapeutic value.It is well known that it is the intention of the Ministry of Health soon to tighten control on the manufacture dispensing and sale of medicines. A system of quality control for manufacturing will certainly be among the requirements and companies in the industry are already examining their organisation to ensure that the control in operation is adequate. 60 ADDRESS OF THE RETIRING PRESIDENT [PYOC. SOC. AyLd. ChtWZ. The various pressures put on the industry has led to a considerable expansion of control and the need for more trained analysts than are available. In all spheres of technology there are not enough analysts to meet the demands but the deficiency appears to be particularly acute in the field under discussion.Analytical chemistry as a career has far more opportunity and interest than it did say fifteen years ago. I would venture to say that for the majority it has as much to offer as pure research. There is some difference of opinion on the academic background required by the analyst. Some maintain that because of the increase in general scientific knowledge with a larger field of study the basic univeristy training must become even longer and specialisation is not desirable until post-graduate level. This special knowledge may be obtained in recognised courses of study or by experience in industry. Others argue that since university courses are becoming increasingly theoretical the student intending to become an analyst should have the opportunity to branch off in the later stages of the syllabus to gain more experience in his essentially practical career particularly since most general post-gradua te instruction is in pure research.On the whole the former opinion has the greater following but that course of action increases the time before the analyst becomes ready for absorption into industry. I am sure there is a need for both forms of training if the academic world is to supply a sufficiency for our needs since by earlier specialisation the graduate can go into industry or other scientific services sooner. The division between the two types of training cannot be so wide that the best of the latter trainees would not make as good analysts as some of those with the post-graduate academic knowledge. The Colleges of Advanced Technology with their new status of technological universities have the opportunity now better than at any other time to break with university tradition to introduce specialist first degrees and serve industry better.Apart from the shortage of qualified analysts there is also the unavailability of the less qualified type of person up to L.K.I.C. standard who is the back-bone of the general analytical control organisations. Deficiencies in the numbers of these technicians inevitably means that senior analysts will have to devote time to more routine work. ,4utomation in production lines and automatic analysis which has been introduced into some industries may release a sufficiency of analysts to fill the gaps in those particular fields. Automatic methods cannot be applied to pharmaceutical production to any great extent.There has been some application in controlling certain plant operations as for example the titres o f antibiotic brews. Most medicinal chemicals are produced in relatively small quantities-a kilogram batch of a potent drug with a 2-mg dose will provide half a million tablets; these drugs are usually costly materials and large stocks can lead to heavy financial investment. STATE COKTROL- The probable introduction of more rigorous control of the manufacture and sale of medicinal products has been mentioned. New drugs introduced on the market must of course be carefully watched because of the possible danger to health of substandard material. Opinion is divided as to how much authority in this respect should be assumed by the state; state control cannot function in the same way as control in the industry where inspection of material during manufacture enables the analyst to assess the significance of a small departure from standard.This does not mean that a certain measure of quality control by the state is not desirable but state legislation should be such that while adequately controlling the sale of medicinal products it would allow flexibility in production; it should also serve as a protection for the reputable manufacturer. In almost all European countries it is the state that is responsible for the inspection of factories and pharmacies and for the collection of samples for analysis by official laboratories. In this country the responsibility rests with local authorities and further the United Kingdom is now the only one o€ the EFTA countries that does not require registration of proprietary medicines.Control of the quality of drugs in this country over and above that exercised by the manufacturing and distributing companies is through the Food and Drugs Act and for labell- ing through the Pharmacy and Medicines Act. The Ministry of Health as purchaser of drugs dispensed under the National Health Service arranges through appointed analysts for the analysis of a small number of samples of medicines obtained on prescription. The hospital services as purchasers of a considerable volume of drugs are also tending to have April 19651 ANNIVERSARY DINNER 61 deliveries examined. Samples taken under the Food and Drugs Act tend to be restricted to those on display for over-the-counter sale-this is to be expected since Food and Drug samp- ling officers sample products bought in the normal course of retail trade; it might be argued that since the bulk of medicinal products are used for self-medication such a preponderance of samples should be in this quarter.However on the whole such products are relatively innocuous and for protection of the public health the more active preparations which cannot be obtained other than on prescription should be given a fair measure of control. The time has arrived when it is apparent that the present system is in need of revision; a number of factors have contributed to this state of affairs. There is at present public concern for an independent assessment of the safety and an assurance of the purity of all drugs placed on the market both home-produced and imported.Further the cost of supplying drugs under the National Health Service is high and the items with proportionately the highest cost are the proprietary drugs which at present are almost free from state control. These and many other factors including exporting to and importing from other countries have had an influence on the decision of the Ministry of Health to institute legislation for a revision and consolida- tion of the national drug laws which would include some form of quality control and they are shaping their policy now. In addition to the control of drugs at the point of sale to the public it is likely that requirements would be laid down for adequate quality control of manu- facture both in the pharmaceutical companies and in hospital pharmacies and supervision of the quality of imported drugs would be imposed.Official control over manufacturing n-ould imply a system of licensing and inspection of manufacturing premises and control 1 aborat ories. Full control of the quality of drugs and their formulations by the manufacturer is a necessity. Legislation should be of such a nature that it will allow the Pharmaceutical industry flexibility in its production but will adequately control the sale of drugs and serve as a protection for the ethical manufacturer. The pharmaceutical industry in this country has a high sense of its own responsibilities as is evidenced by the high quality of its products Ivith little outside control. In the time at my disposal I have briefly indicated the changing outlook on the control and standardisation of pharmaceutical products and the breadth of experience required by the analyst. ‘There is a need for a large amount of analytical research in the pharmaceutical and allied fields. 1 hope this Address has given those in other branches of the profession some insight into the scopc of work and the problems facing the analyst in pharmaceutical industry.

ISSN:0037-9697    

DOI:10.1039/SA9650200055

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

April 19651 ANNIVERSARY DINNER Anniversary Dinner THE Biennial Dinner celebrating the 91st anniversary of the Society was held at Merchant Taylors’ Hall Threadneedle Street London E.C.2 in the evening of Friday March Fith 1065 after the Annual General Meeting. The reception was by the President Dr. D. C. Garratt and 139 members and guests were present. Professor A. C. Frazer C.R.E. Professor of Medical Biochemistry and Pharmacology in the University of Birmingham was the Guest of Honour and other guests of the Society and of the President were Professor D. H. R. Barton F.R.S. Vice-President of The Chemical Society Professor I,. Young Vice-president of The Royal Institute of Chemistry and Mrs. Young Mr. C. IV. Maplethorpe President of The Pharmaceutical Society o€ Great Britain and Mrs.Maplethorpe Mr. A. I,. Williams President of l h e Association of Public Analysts and Mrs. Williams and Mr. I). Ducat Master of the Merchant Taylors’ Company and Mrs. Ducat. After the Loyal Toast proposed by the President Professor Frazer proposed the toast of The Society which he likened to a very active and fertile body whose offspring were the Geographical Sections in various parts of the country and the specialised Subject Groups. His associations with food drugs and agricultural products involved him in many matters that concerned the Society. Relatively recently it had been realised that in the fields of food additives and of drugs specification was a matter of vital importance Many people talked about the toxicology of drugs without full ltnowledge of the subject. The compositions of many commercially available products were not fully identified especially pesticides and this was an important factor from the point of view of the analytical chemist.It was always possible by the use of highly sensitive techniques to show the presence of minute portions of 62 ANNIVERSARY 1) INNER [Proc. SOC. Anal. Chem. some adventitious substances. Analysts were under some obligation to ensure that the results they had produced so skillfully should not be wasted by wrong use. For example pesticides residues detected in the bodies of birds and beasts were not necessarily the cause of death; toxicologists had to be encouraged to place a proper interpretation on the analytical results. Although analysis was an important step there should be in toxicology not perhaps some laws for the rich and others for the poor but certainly different laws for the fat and for the thin.He exhorted analysts not to allow anybody to use their very great achievements for improper objectives. They must be aligned with the achievements of scientists of other disciplines so that all were used to the best advantage of the community. I’vofessor Prazer being received by the Preside& DY. Gawatf. Dr. Garratt responding to the toast thanked Professor Frazer for the encouragement he had given to the Society. Its success was due to the unstinting efforts of voluntary workers allied to the work of the permanent staff. As a result of these efforts it kept abreast of de- velopments as demoatrated in tlie new Group Strncture. Attendances at meetings were very encouraging; one symposium had drawn an audience of over 500.He expected the forth- coming Congress in Nottinghain to be even more popular. Ilr. Garratt concluded with a special expression o€ thanks to the Master and the Merchant ‘Taylors’ Company for allowing the Society the privilege of dining in their Hall and for permitting guests to tour the Hall after dinner to inspect tlie liistoric Great Kitchen and the 14th century Crypt as well as the Corn- pany’s plate and collection of portraits. (I,-R) MY. R. C . Chirnside (Past Pyesident) MY. A. A . Smales and MYS. Smales April 19651 ANNIVERSARY DINNER 63 He made particular mention of Professor Frazer’s work as Consultant on metabolic diseases to the British Army and his Chairmanship of at least four national and international committees. Resides these distinctions lie had been the Society’s Bernard Dyer Memorial Lecturer and Medallist five years ago.Dr. Amos then spoke of Professor Barton’s pre-eminence in that on three occasions he had been the first to receive a newly introduced medal awarded by a Scientific Society or to give a newly introduced Memorial Lecture. He also mentioned the other guests including Mr. Ducat the Master of the Merchant Taylors’ Company. Finally he welcomed the Ladies who were as ever the graceful part of the occasion. Dr. Amos Past President proposed the toast of the Guests. Dv. Gavvatt with Pvofessov D. I$. R. Barton Professor Barton replying for the Guests said that analytical chemistry in the Universi- ties was regaining some of the recognition accorded to it in the nineteenth century. Then many Professors of Chemistry were practising analysts and it was generally recognised that sound analytical work was the basis of all chemistry. Views had changed and this century there had until recently been essentially no Professor of Analytical Chemistry. There were now two and the number of Chairs was shortly to be raised by 50 per cent. by the appointment of Dr. T. S. West at present Reader to be Professor in Analytical Chemistry at Imperial College. (I-R) Dv. and MYS. R. E . Stznckey M Y . and MYS. C . W . Maplethovfx and DY. Norman E 7 ~ s The proceedings concluded with Dr. Garratt investing Mr. Smales the incoming Presi- Mr. Smales presented Dr. Garratt with a replica of the dent with the Presidential Badge. Society’s Badge to wear as Past President.

ISSN:0037-9697    

DOI:10.1039/SA9650200061

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

64 MEMBERSHIP CHANGES [Proc. SOC. Anal. Chem. Changes in the Register of Members NEW MEMBERS ORDINARY MEMBERS Harold Bernard Raslter B.Sc. (Cape Town) ; James Albert Brammer A.1C.I.C. ; John Norman Brazier; Enrico Cerrai Dr.Chem. (Pisa) ; John Raymond Cooke RSc. Ph.D. (Manc.) ; Joseph David Curzon R.Sc. (Lond.) A.R.C.S. F.R.I.C. ; Hugh Trevor Delves A.R.I.C. A.C.T. (Liv.) ; Jahannes Pieter Goddijn; David Dollirnore B.Sc. P1i.D. (Lond.) F.R.I.C. J*P. ; Paul Edward Dudman L.R.I.C. ; Robert Ellerlter A.M.I.S.P. ; Richard Leyton Evans L.R.I.C. ; Eric Jesse Grayson B.Sc. (Tech.) Rii.Inst.F. M.I.Gas E. A.F.Inst.Pet. ; Peter Ernest Haywood; Kenneth Edwin Holmes BSc. (Lond.) F.R.I.C. F.R.A.C.T. ; David Ferguson Ingram M.Sc. (Otago) ; John Leonard Oliver Jones; Alan James Macfarlane €3.5~. (Wales) A.R.I.C. M.Inst.Pkg. ; Robert Cameron Mackenzie Ph.I>. D.Sc. (Edin.) F.R.I.C. F.G.S. F.1I.S.E. ; Wilmar Manz B.Sc. Ph.D. (Lond.) A.R.I.C. ; Robert Henry McKeown M.Sc. (N.Z.) M.P.S. ; Shingo Miyalte Dr.Tech. (Tokyo) ; Ronal Moss A.R.I.C. ; Teo Teng Poh R.Sc. (Malaya) A.R.I.C.; Stuart Austin Reed B.Sc. (Lond.) F.R.I.C.; Edmund Joseph Peter Schilling; Alan Sirne A.K.I.C. ; Francis Robert Soer B.Sc. (Lond.) M.Sc. (Sheff.) A.R.I.C. ; Ronald Ernest Starr ; David Frederick Stoker. JIJNIOR MEMBERS David Anthony Michael Edwards B.Sc. (Sheff .) ; Robert John Fryer; John Edward Fulleylove; Michael Arthur Potts; John Melvin Reid; Ian Charles Walker L.II.1.C. ; Thomas Edward Wallbank B.Sc. (Lond.) DEATH WE record with regret the death of James Charles Manuel.

ISSN:0037-9697    

DOI:10.1039/SA965020064b

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

April 19651 PUBLICATIONS RECEIVED 65 Publications Received The publications listed below have been received by the Editor of The Analyst in which journal Book Reviews will continue to appear. AN INTRODUCTION TO PARASITOLOGY. CONFERENCE ON THE VIBRATIONAL SPECTRA OF HIGH POLYMERS. By JOEIN M. WATSON D.Sc. A.R.C.Sc. Pp. viii 4- 184" Edited by GIULIO NATTA New York and London Interscience Publishers a London William Hejnemann Medical Books Limited. 1965. Price 20s. and GIUSEPPE ZERRI. division of John Wiley & Sons Inc. 1964. Price 75s. Pp. vi + 226. Repvinted fvom Journal of Polymer Science Pavt C Polymev Symposia No. 7. THEORETICAL BASIS OF INORGANIC CHEMISTRY. By A. K. BARNARD B.Sc. Ph.l>. F.1t.I.C. Pp. x + 372. New York London and Toronto McGraw-Hill Publishing Company 1.imited.1965. Price 50s. STANDARDMETHODEN DER PRAKTISCHEN CHEMIE PRAPARATIVE METHODEN DER ORGANLSCHEN CIIEMIE. PART 11. AZOFARBSTOFFE. Edited by ERNEST POULSEN NAUTRUP IRMA J~~RGING DIETER HOPPE and J ~ R G E N GOMANN. Pp. viii + 44 (loose leaf). Braunschweig Germany Friedr. Vieweg & Sohn. 1964. Price DM 5.90. PART I. LIST OF PAPERS WITH INDEX BY AUTHORS. Supplement No. 15. Edited by L. JELLICI and L. GRIGGIO. Pp. 108. Rome Consiglio Nazionale Delle Richerche. 1964. Price L. 1800; $3.60. BIBLIOGRAFIA POLAROGRAFICA (1962). PART 11. INDEX BY SUBJECTS. Supplement No. 15-A. Edited by L. JELLIC~ and L. GRIGGIO. Pp. 147. Rome Consiglio Nazionale Delle Richerclie. 1964. Price 1,. 2400; $4.80. Edited by 1)R. Id. T A N G . Pp. 416 + index pp. 417-444. Budapest Akademiai Kiad6. 1965. Price with index $18.00.CHEMISTRY I N BRITAIN. Editors F. MT. GIBBS Ph.l). 1).Sc. F.K.I.C. arid DIANA P. E. BOATMAN B.A. A.R.T.C. London The Royal Institute of Chemistry and The Chemical Society. BIBLIOGRAFIA POLAROGRAFICA (1922-1962). ABSORPTION SPECTRA IN THE TJLTRAVIOLET AND VISIBLE IZEGION. Volume v. Volume 1 No. 1 January 1965. Pp. 46. Annual subscription 100s. A New Jownal. RODD'S CHEMISTRY OF CAKBON COMPOUNJX. Volume 1 Part B. Edited by S. COFFEY M.Sc. D.Sc. F.R.I.C. Second Edition. Pp. xvi 4- 313. Amsterdam London and New York Elsevier Publishing Company. TITRATIONS IN NON-AQUEOUS SOLVENTS. T3y J ~Iii KUCHARSKT~ R.N. Tlr. and LJJDBK ~ A I ' A ~ ~ K Ph.Mr. Second Edition. Pp. xii $- 286. Amsterdam London and New York Elsevier Publishing Company. 1965. Price 70s. By S. lt. KAFIKOV S. A.PAVLOVA and I. I. TVERDOKHLEI~OVA. Jerusalem Israel Program for Scientific Translations. Distributed by Oldbourne Press London. 1964. Price 99s. INTERPRETED INi'RARED SPECTRA. Volume 1. By HERMAN A. SZYMANSKT. Pp. viii -+ 293. New York Plenum Press. 1964. Price $10.75. ANALYSIS INSTRUMENTATION-l964. Edited by 2. FOWLER li. J. HARMON and 1). I<. I<oe. Pp. x + 340. New York Plenum Press. 1964. Price $14.50. Pvoceedings of the Tenth National Analysis 1 nstvumentation Symposium held Jw6e 1-3 1964 at S a n Fvancisco Califovnia. GUIDE TO GAS CHROMATOGRAPHY LITERATURE. By AUSTIN V. SIGNEUII. Pp. vi + 351. Xew York Plenum Press. 1964. Price $12.50. PROGRESS m INFRARED SPECTROSCOPY. Volume 2. Edited by HERMAN A. SZYMANSKI. Pp. iv 4- 298. New York Plenum Press. 1964. Price $12.50. Rased on lectwes fvom the Sixth and Seventh Annual Infvaved Spectifoscopy Institzdes held at Canisizzs College BuJYalo New Yovk 1962 and 1963. 1965. Price 100s. ; (subscribers to the series) 90s. I~ETERMINATION OF MOLECULAR WEIGHTS AND POLYDISPERSITY OF HIGH POLYMERS. Pp. viii + 357.

ISSN:0037-9697    

DOI:10.1039/SA9650200065

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

66 SAC CONFERENCE 1965 [Proc. SOC. Anal. Chem. SAC Conference 1965 THE following programme subject to minor alterations has been arranged for the SAC Conference to be held at Nottingharn University in July. Monday July 19th 11 a.m. Opening Address by A. A. Smales O.B.E. R.Sc. F.R.I.C. (A.E.H.E. Haveuell 2.15 p.m.-3.20; 3.50-4.55 p.m. England) . “Analytical Chemistry-Science or Technology?” Session A “ A Standard Biological Material for Elementary Analysis,” by H. J. %I. Rowen (University of “The Examination and Determination of Cephaloridine,” by J. L. NIartin and W. H. C. Shaw “Analysis of Phosphatides by Means of Potentiometric Titration in Non-aqueom Medium,” “Fundamental Studies in Automatic Iligestion,” by J . I;. Marten and G. Catanzaro (Technicon Heading E n g l a d ) . (Glaxo Laboratories Ltd.England). by P. Smits and J . Kuiper (Unilever Research Laboratorium The Nethevlands) Instvumevzts Co. Ltd. England). Session B “A Prototype X-Ray Milliprobe Analyser,” by 12. W. J. Garton J. T. Campbell and J . Watling (Ti. K . A .E.A . England). “’The Determination of Microgram Amounts of Zirconium in IJranium and Steel by X-Ray Fluorescence Spectroscopy,” by 13. L. Tavlor ( A .E.R.E. Hnrwell Englavzd). “A Study of Silicon Determination in Organo-silicon Compounds by X-Ray Fluorescence with Vacuum Spectrograph,” by J;. T,. Chan (Aerospace Research Laboratories 7J.S.A .). “Analysis of Plastics Materials X-Tiay Fluorescence Examination of Volatile Liquids with the l’hilips PW1540 Spectrometer,” by D. C. M. Squirrel1 (Impevial Chemical JndustYies Ltd. Plastics Division England) .Tuesday July 20th Session A 9.30 a.rn.-10.35; 11.05-12.45 p.m. “Studies in the Relationship between Molecular Structure and Chromatographic Hehaviour. Part I V. The Bchaviour of Some Xitrophenols Chromatographed by Partition Chromato- graphy,” by L. S. Hark and E i . J. T. Graham (Royal College of Advnmed Technology Salfovd England). “The Use of Thin-layer and Semi-preparative Gas - Liquid Chromatography in the Detection Determination and Identification of Organo-phosphorus Pesticide Residues ” b y D. C. Abbott N. T. Crosby and J . Thomson (Laboratory of the Government Chemist Ministvy of Technology England). “Some Fundamental Aspects in the Practice of Thin-layer Electrophoresis,” by v\i. J . Criddle G. J . Moody and J . D. R. Thomas (WeEsh College ofAdvanced Technology Card@ Wales).“The Quantitative Analysis of Fatty Alcohol - Ethylene Oxide Adducts by ’Thin-layer Chromatography,” by T. D. Heyes ( Unilever Research Laboratory Port Sunlight England). “The Direct Conductimetric Titration of Acidic and Basic Compounds liesolved by Thin-layer Chromatography,” by W. Roardrnan and B. Warren (Hatfield College of Technology England). Session B “The Determination of Some Light Elements by Charged-particle Activation Analysis and Measurement of Prompt Radiation,” by T. B. Pierce and P. F. Peck (A.E.R.1;3, Havwell England) “The Determination of Microgram Amounts of Fluoride by a Pyrohydrolytic Iaithanum - Alizarin Complexan Procedure Designed for Plutonium-containina Materials,” by A. G. Davies and J . K. Foreman ( U . K . A . E . A . Production Group England).“The Determination of Tellurium in Gallium Arsenide and Germanium by Xeu tron Activation Analysis,” by K. W. Lloyd (Mullard Research Laboratories England) . ‘ ‘ Spectrochemical Analysis of Radioactive Materials. Part VIT I . The Spectrographic Analysis of Minute Samples,” by V. Svoboda (Institute for Reseavch Production and Use of Radioisotopes Czechoslovakia). “The Determination of Rare Earths in Substituted Yttrium Iroii Garnets by Neutron Activa- tion and yKay Spectrometry,” by K. W. Lloyd and E. J . Millett (Mullard Research Laboratories England). April 19651 SAC CONFERENCE 1965 67 2.15 p.m.-3.20; 3.50-4.55 p.m. Session A “The Analysis of n-Alcohol - Ethylene Oxide Adducts by Gas - Liquid Chromatography,” by W. Lazarus (Unilevev Reseavch Laboratory Povt Sunlight England).“Organic Trace Analysis by Measurement of Photoluminescence,” by C. A. Parker (A dwziralty Matevials Labovatovy England) . “Recent Advances in the Analysis of Poly(viny1 chloride) Compositions,” by 1,. H. liutldle S. I>. Swift J . Udris and P. E. Arnold (I~rnpevial Chemical Industvies Ltd. Plastics Division England). “An Infrared Method for the Determination of Small Amounts of A4cetaldehyde in Aqueous Solution,” by D. M. W. Anderson and J . I;. Stoddart (Univevsity of Edinbuvgh Scotland). Session B “The Application of Coi?tri>lled-potentiaI Coulouietry to the Determination of Plutonium,” by G. Phillips and G. W. C. Milner (A.E.R.E. Havwell Evlgland). “Electrophoresis on Cellulose Acetate Membrane in Strong Electrolytes Determination of the Electrophoretic Mobility of Some Actinide Elements in Hydrochloric and Nitric Acids ’ ’ by F.Clanet (Centve d’Etudes Nucleaives France). “Some Aspects of the Spectrochemical Analysis of the Actinide Elements,” by 17. T. 13irks (A.E.R.E. Harzuell Evtgland). “The Determination of Some Constituents of Rocks and Minerals by Fast-neutron Activation Analysis,” by J . M. Bakes P. G. Jeffery D. W. Downton and J. D. I,. H. Wood (Wavven Spying Labovatovy Ministvy of Technology England). Wednesday July 21st 9.30 a.m. Lecture by A. T. James U.Sc. Ph.13. (Unilevev Iieseavch Labovatovy Shavuzbvook E?gland). “Adventures in Chromatography. ” Thursday July 22nd 9.30 a.m.-10.35; 11.85-12.45 p.m. Session A ‘ “l’itrimetric Quality (Q) of and 1;easibility for Symmetrical Ion Combination Reactions having Products of Constant Activity,” by E.I3ishop (Univevsity of Exetev Epgland). “ Arninoanthraquinone indicator Dyes and their Application,” by I . Krausz and A. Endriii- Havas (IvLstitute of Inovganic avld Analytical Chemistry Hungavy) . “The 13etermination of Trace Amounts of Silver with Diphenylthiocarbazone in High-puri t y Cobalt Lead Nickel Zinc and Other Metallurgical Products,” b y 11. Carson and El. G. Walliczek (Kholzana Covpovation Ltd . Zambia). “The Determination of Tndium by Solvent Extraction Followed by EDTA Titration,” by J . A. Clements and T. Davies (Robevtson Research Co. Ltd. Wales). “A Kinetic and Titrirnetric Study of the Determination of IronII with Potassium Bromate,” by J . M. Ottaway and E. Bishop (Uniuevsity of Exctev England). Session B “ll‘henoyltrifluoroacetone a Fluorimetric Reagent for Europium and Samarium,” by I t .14:. I3allard and J . W. Edwards (A.E.K.E. Haywell England). ‘“l’he Determination of Commonly lised Non-ionic Detergents in Sewage Effluents by a Thin- layer Chromatographic Method,” by S. J. Patterson E. C. Hunt and K. 13. E. Tucker (I*abovatovy of the Govevvlment Chemist Ministvy of Technology England) . “The Determination of Total Chlorine Available in Waters,” by L. S. Hark and H. G. Higson (Royal College of Advanced Technology Salfovd England). “1;actors Affecting the Formation and Solvent Extraction of the Complex of Nickel with Vuril a-Dioxime,” by A. I,. Wilson (Centval Electvicity Reseavch Labovatovies England) . “The Determination of Certain Trace Metals in Very Pure Waters by Automatic Analysis,” by I;. A. Pohl (A llgevneine Elektvicitats-Cesellschaft Gevmany).2.15-3.20; 3.50-4.55 p.m. Session A “Studies on Nickel11 Dioximes of Analytical Importance,” by R. J . Magee and Id. Gordon (The Queen’s Univevsity of Belfast I yeland). “The Determination of Microgram Amounts of Osmium with N-(4-Aminophenyl) morpholine,” by I,. S. Bark and D. Brandon (Ro-yal College of Advanced Technology Salfoyd England). “Control and Assessment of Systematic Errors by Routine Analytical Work,” by I). L. Lydersen (SINTEF Novway). “Some Applications of Polarography in Physiological Analysis,” by R. C. Rooney (.5outhern Analytical Ltd. England). 68 SAC CONFERENCE 1966 [Proc. SOC. Anal. Chem. “Construction and Applications of an Electrolytic Hygrometer,’’ by H. J. Cluley and J. E. Still (The General Electric Co. Ltd. England).“Voltammetric Studies with Different Electrode Systems. Part 1. Molybdenum as Reference Electrode in Polarography,” by V. T. Athavale S. V. Rurangey and It. G. Dhaneshwar ( A tonzic Energy Establishment Trombay India). “Electroanalytical Chemistry of Hot-water Solutions,” by A. J . Ellis and G. J. Hills (Uniuev- sity of Southampton England) “llifferential Electrolytic Potentiometry. Part XVII. An Lnterpretation of DEP as a Linear Diffusion Process,” by E. Bishop (Univevsity of Exetev England). Session B Friday July 23rd Session A 9.30 a.m.-10.35; 11.05-12.45 p.m. ‘ “The Colorimetric Determination of Vanadate in the Presence of Chromate Molybdate Tungstate and Nitrate with 4-(2-Pyridylazo)-resorcinol,” by W. J . Geary and C. N . Larsson (Lanchester College of Technology Coventvy England).“Organic-phase Spectrophotometric Deterniination of Iron111 with Thiocyanate after Extrac- tion with Di-(2-ethylhexyl)orthophosplioric Acid from Chloride Solutions,” by E. Cerrai and G. Ghersini (Labovatovi C.I.S.E. I t a l y ) . “The Spectrofluorimetric Determination of Microgram Amounts of Scandium with Salicyl- aldehyde Semicarbazone,” by 6. F. Kirkbright ‘1. S. West and C. Woodward (lm$erial College of Science avLd Technology England) . “The Automation of Anion-exchange Chromatography of Phosphorus Anions,” by F. H. I’ollard C;. Kickless D. E. Liogers and I). L. Crone (Univevsity ofBvisto1 Ev~gland). ‘‘ A Crj tical Evaluation of Differential lieaction-rate Methods Employed for the Simultaneous Analysis of Closely Related Mixtures. Part I. First-order and Pseudo First-order Methods,”byH.B. Mark jun. K. A. Greinke and I,. J . Papa (Univevsityoff~ichiRan U.S.A .). Session B “A Study of the Mechanism Underlying the Separation of Rare-earth Elements by Paper Chromatography,” by I). I. Ryabchikov Cr. M. Varshal and M. M. Seniavin (Academy of Sciences of the U.S.S.K. Moscow). ncapsulation as a Technique for the Determination of Hydrogen in Volatile Metals,’’ by 1;. I<. Coe N. Jenkins and 11. H. t’arker (Hyztish Welding Reseavch Association England). ‘‘?‘he Spectrophotometric Determination of Sub-microgram Amounts of Impurities in Senii- conductor Materials,” by J . A . Roberts J . Winwood and E. J . Millett (Mullavd Neseavch T2abovatovies E n g l a d ) . “ I Jse of iiadionuclides to Study the Adsorption of Cations on Carboxycellulose Ion Ex- changers,” by E.Kiiriis Zs. liemport-Horvath A. Lasztity and E. Schulek (Institute of tnovganic a d A nalytical Chemistvy Huwgavy) . “A Rapid Method of Determining Soluble Silicates,” by R. M. Milwidsky and S. Holtzman (Zohav Soap and Detergent Factory Isvael) . 2.15 p.m. Closing Session. The time allotted to each paper will be strictly regulated so that interchange between the concurrent sessions will be possible. In addition to the scientific content of the Conference detailed above a full social programme has been arranged details of which are given on the descriptive brochure that may be obtained together with enrolment forms on application to the Secretary of the Local Committee Mr. A. S. Beidas Standards Department Roots Pure Drug Co. Ltd. Station Street Nottingham England. Further information on any other aspect of the Conference may be obtained by writing to the Secretary of the Executive Committee Mr. C. A. Johnson The Society for Analytical Chemistry 14 Belgrave Square London S.W.1.

ISSN:0037-9697    

DOI:10.1039/SA9650200066

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

April 19651 NOTICES 69 Notices CARCINOGENIC COMPOUNDS USED AS ANALYTICAL REAGENTS T H E Ministry of Labour is proposing by Statutory Instruments to prohibit the manufacture handling storage use and importation of certain carcinogens including benzidine base. Specific exceptions may be granted for research purposes but the wording of the draft regulations implies that such exceptions would not be extended to analytical reagents used for the detection of occult blood and hydrogen cyanide in effluents for which benzidine may now be used. Because the use of this material may be entrusted to those who may not be aware of the dangerous nature of the product every effort should be made to replace benzidine at once as a reagent by alternative non-toxic reagents. An alternative test for occult blood cxists in which the reagent is o-tolidine and a dye leuco patent blue can be used in place of henzidine in the Pickworth demonstration of haemoglobin.The Council of the Society wishes to publicise the view that non-toxic altern a t' ive reagents or alternative techniques should be used to replace benzidine as an analytical reagent in all its applications. BRITISH STANDARDS INSTI'TUTION A FEW copies of the following draft specifications issued for comment only are available to members of the Society and can be obtained from the Secretary The Society for Analytical Chemistry 14 Relgrave Square London S.W.1. Draft Specification prepared by Sub-committee NFE/23/4-Sampling and Analysis of Magnesium and Magnesium Alloys. Il65/1418-Draft I3.S. Methods for The Analysis of Magnesium and Magnesium Alloys Part 2 Iron (Photometric-1 10 Phenanthroline Method).I)65/1419-Draft R.S. Methods for The Analysis of Magnesium and Magnesium Alloys Part 3 Copper (Photometric). U65/1420-Draft K.S. Methods for The Analysis of Magnesium and Magnesium Alloys Part 4 Manganese (Photometric-Periodate Method). D65/1421--Draft B.S. Methods for The Analysis of Magnesium and Magnesium Alloys Part 5 Manganese (Photometric-Periodate Method) (low contents). Draft Specifications prepared by Sub-committee PVC/l /lo-Miscellaneous Pigments. D65/1596-T>raft B.S. Specification for Chromium Oxide Pigments (Revision of D65/1597-Draft B.S. Specification for Ultramarine Pigments (Revision of B.S. 314). D65/1879-Draft B.S. Methods of Test for Flow of Glass Fabric Impregnated with Synthetic Resin (B.S.2782-Method 105 D) Percentage of Volatile Matter in Glass Fabric Impregnated with Synthetic Resin (R.S. 2782-Method 207 H and Resin Content of Glass Fabric Impregnated with Synthetic Resin (R.S. 2782 -Method 107 J). DRAFT SPECIFICATIONS B.S. 318). Draft Specification prepared by Technical Committee PLC/l'I-Testing of Plastics. 70 FORTHCOMING MEETINGS [YYOC. SOC. Anal. Chem. Draft Specification prepared by Technical Committee CIC/20-Sulphur Hydrochloric and Sulphuric Acids. D65/1992-Draft B.S. Methods of Test for Sulphur. Draft Specifications prepared by Sub-committee CIC/l 1 /I-Food Colouring Matters D65/1993-Draft B.S. Specification for Eyrthrosine RS for Use in Foodstuffs. D65/1994-Draft B.S. Specification for Indigo Carmine for Use in Foodstuffs. D65/1995-Draft B.S. Specification for Green S for Use in Foodstuffs. D65/1996-Draft R.S. Specification for Blue VRS for Use in Foodstuffs. (Coal Tar).

ISSN:0037-9697    

DOI:10.1039/SA965020069b

出版商:RSC    

年代:1965

数据来源: RSC