摘要:

of the Society for roc. SOC. Anal. Chern. Vol. 2 No. 3 Pages 29-40 Analytical Chemistry CONTENTS Reports of Meetings . . . . 29 Papers accepted for The Analyst 3 I “Toxic Substances in Air” . . 32 Publications Received . .. 36 Membership changes . . . . 36 SAC Conference 1965 .. .. 37 Notices .. .. .. . . 38 Forthcoming Meetings . . Back Cover March 1965 Vol. 2 No. 3 March 1965 PROCEEDINGS THE SOCIETY FOR ANALYTICAL CHEMISTRY OF President of the Society A. A. Smales O.B.E. Hon. Secretary of the Society S. A. Price Hon. Treasurer of the Society D. T. Lewis C.B Hon. Assistant Secretaries of the Society B. S. Cooper; D. W. Wilson Secretary Miss P. E. Hutchinson 14 BELGRAVE SQUARE LONDON S.W.l Telephone BELgravia 3258 Editor J. B. Attrill Proceedings i s published by The Society for Analytical Chemistry and distributed t o members and all subscribers t o The Analyst without charge Single copies may be obtained direct from the Secretary The Society for Analytical Chemistry a t the above address (NOT through Trade Agents) price 2s.6d. post free. Remittances payable to “Society for Analytical Chemistry” MUST accompany orders THE SOCIETY FOR ANALYTICAL CHEMISTRY Particle Size Analysis Conference 1966 A Conference will be held at Loughborough College of Technology Leicestershire September 14th to 16th 1966 Papers and discussions will describe original work in the field covered by the review of particle size analysis published in The Analyst 1963 88 156-187. Critical comparison of methods and description o f new techniques will be welcome but review articles will be inappropriate Full details will appear shortly but in the meantime offers o f papers for the Conference will be welcomed by the Conference Secretary at the Society’s Offices preferably on the postcard distributed with this issue I

ISSN:0037-9697    

DOI:10.1039/SA96502FX008

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

THE SOCIETY FOR ANALYTICAL CHEiMISTRY Forthcoming Meetings-continued April “Centrally Acting Hypoteiisives,” by Ti. C. Elliott U.Sc. Ph.D. “Anti-(lepressc2nts,” by A. W. Tlessin 13.Sc. “Analgesics with Special Reference to llrug lkpendence,” by Ti. 15. Lister Closing remarks by Professor G. A. H. Euttle O.B.E. M.A. M.R.C.S. School o f Pharmacy Rrunswick Square Lonclon W.C. 1 ; 10 a.m. MICIIOCHEMICRL MriTHorx G R ~ U P and SPECIAL Tri;cHNIj]rrEs (;ROTJP Fviday ’Tour of the Tiniversity of Sussex; 2.15 p.m. “Some Advances and Trends in infra-red Spectroscopy,” by I). M. W. ‘The Study of Chelate Compounds by Infra-red Spectroscopy,” by Xi. J. “I nfra-red Spectroscopy Applied to Very Small Quantities,” by H. A. Willis. 1 .ecturc Theatre Room 102 Physics Building [Jniversity of Sussex l;almer Satuvday “lnfra-red Spectra of Inorganic Materials,” by 13.1;. Evans. “The Application of rmg-psth (40 m) Gas Cells to the Analysis of Atmospheric “Tnfra-red Analysis by Attenuated Total Reflectance,” by N . A. Puttnam 1,ecture Theatre lioom 102 Physics Building University of Sussex Falmer r3.sc. Ph.1). T,.IZ.C.P. l;riday 9th and Saturday 10th 13 II 1 G H T o N Joint Meeting on “ Infra-red Spectroscopy.” Anderson E.Sc. Ph.]). F.1i.I.C. Magee,M.Sc.,Ph.I). v.r.c.l. F.R.T.C. firighton ; 6.45 p.m. t)ollution,” by I,. C. Thomas H.Sc. Y.IZ.1.C. E3.Sc. 1’11.1 I . A.L;.Inst.Pet. A. 1Z.I.C. Brighton; 9.45 a.m. Wccliiesclay 1 4th ATOMIC-AI~SO KI’TION SPw’r Koscow GROUP One-day exhibition demonstra - Sheffield College o f Technology Pond Street Shefield 1. SH I S F I T 1 15LT> tion and discussion on “Commercial Atomic-Absorption Apparatus.” Wedncsclay 21st MIDLANDS SECTION jointly with the Lea Valley Section of the Boyal Speakers J.F. Marten Ph.D. A.R.I.C. and G. V. R. Mattock I3.Sc. Ph.I). 1,uton and South Red forclshire College of Further Education Park Square L~JTON Institute of Chemistry on “Automatic Methods of Analysis.” A. R. I. C. Luton ; 6.45 p.m. March ‘Tuesday 23rd BIRMINGHAM Friday 26th FALKIKK ’Tuesday 30th NOTTINGHAM Wednesday 3 1 st IdON130N April Friday 2nd SWANSXU Tuesday 6th T H E SOCIETY FOR ANALYTICAL CHEMISTRY Forthcoming Meetings MIDLANDS SECTION and SPECIAL TECHNIQUES GROUP on “Use of the Electron Microprobe. ’ “Electron-probe Analysis in Mineralogy,” by J. V. P. Long M.A. Pli.D. A. 1 nst . P. “Metallurgical Applications of the Electron-probe X-ray Microanalyser,” by M.J. Fleetwood M.A. Grad.1nst.P. Haworth Lecture Theatre The Tiniversity Edgbaston Birmingham 15 ; 6.30 p.m. 2.30 p.m. Visit to the International Nickel Co. (Mond) Ltd. Wiggin Street Birmingham 16. SCOTTISH SECTION. “Determination of Trace Constituents in Metallurgical Samples,” by W. T. Elu~ell F.R.1 .C. “The Principles of Radioactivation Analysis,” by H. W. Wilson 13.Sc. Ph.ll. F.Inst.P. F.R.S.E. Technical College Falkirk; 7.15 p.m. NORTH OF ENGLANI) SECTION and MII3LANDS SECTION. “Sugar Analysis,” by R. Butler. “The Application of Modern Techniques to Special Problems in Sugar Analy- “The Characterisation of Fats,” by C. B. Barrett B.Sc. Ph.D. A.R.I.C. “The Characterisation of Fats Examples of the IJse of Old and New Methods of Analysis,” by K.A. Williams B.Sc. PhD. F.R.I.C. A.Tnst.Y. M.1nst. Pet. Lecture Theatre Roots Pure Drug Co. Ltd. Pennyfoot Street Nottingham; 10.30 a.m. SocImy Meeting on “Food Analysis.” “A liapid Method for the Estimation of Benzoic Acid in Soft Drinks,” by M. A. “The Analysis of Orange Juice,” by I). R. Lisle B.Sc. l2h.D. “Determination of Cyclamates in Soft Drinks,” by 1). J. Hees M.Sc. Pli.D. Meeting Room of the Chemical Society Burlington House Piccxlilly sis,” by D. Gross Ph.D. Ford. A.1Z.I.C. London W.l; 7 p.m. WESTERN SECTION. “Some Applications of Nuclear Spectroscopy to Analysis,” by T. B. Pierce University College Swansea 6.34) p.m. NOIZTH OF ENGLAND SECTION and MIDLANDS SECTION. B.Sc. M.A.. D.Phil. SmKis-oN-TneN*r “ Inorganic Applications of Infra-red Spectroscopy,” by K. J. Magee M.Sc. Ph.Il. F.R.I.C. F.I.C.I. M.1I.S.H. “The Examination of Clays and Slag Materials,” by P. S. Keeling. Lecture Theatre North Staffordshire College of Technology Stoke-on-Trent ; BIOLOG~CAL MICTH~DS GI~OUP Symposium on “The Pharmacological Screening Introduction by F. Hartley K.Sc. Ph.T>. F.P.S. F.II.1.C. “Organisation of Pharmacological Screening Tests,” by J . 1I. Vane H.Sc. “Statistics for Pharmacological Screening,” by J. J. Grimshaw B.Sc. “Anti-fertility Agents,” by D. K. Vsllance B.Sc. Ph.D. 7.15 p.m. Wednesday 7th LONDON of New Drugs.” 1l.Phil. Continued inside back cover PRINTED BY w. n E w m dr SONS LTD.. CAMBRIDGE. ENGLAND.

ISSN:0037-9697    

DOI:10.1039/SA96502BX010

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

March 1965 PROCEEDINGS OF THE SOCIETY Vol. 2 No. 3 FOR ANALYTICAL CHEMISTRY Reports of Meetings EXTRAORDINARY GENERAL MEETING Ax Extraordinary General Meeting of the Society was held at 2.30 p.ni. in London on Friday March 5th 1965 the President occupying the Chair. A Special Resolution was proposed for altering certain Clauses in the Society’s Articles of Association amongst other matters altering the ex-oSJicio membership of the Council and after discussion this Resolution was carried nem. con. ANNUAL GENERAL MEETING ?’HE ninety-first Annual General Meeting of the Society was held at 2.45 p.m. on Friday March 5th 1965 in the Meeting Room of the Royal Society Burlington House Piccadilly London W.1. The Chair was occupied by the President Dr. D. C. Garratt Hon. M.P.S. F.R.I.C. The Financial Statement for the year ending October 31st 1964 was presented by the Honorary Treasurer and approved and the Auditors for 1965 were appointed.The Report of the Council for the year ending March 1964 (to be published next month) was presented by the Honorary Secretary and adopted. The Scrutineers Miss A. M. Jones and Mr. I3. Harris reported that the following I d been elected officers for the coming year- PresidePzt-A. A. Smales O.B.E. B.Sc. F.R.1 .C. Past Presidents serving on the Council-A. ,J. Amos 13. C. Chirnside D. C. Garratt and Vice-Preside?&-A. G. Jones and C. Whalley . Howorary Treasurer-D. T. Lewis C.R. Honorary Secretary-S. A. Price. Hofiorary Assistant Secretaries-R. S. Cooper (Programmes) and 1). W. Wilson. Other Members of Council-The Scrutineers further reported that 410 valid ballot papers tiad been received and that votes had been cast in the election of Ordinary Members of Council as follow- T.S. West 340; H. M. N. H. Irving 327; R. E. Stuckey 287; W. C. Johnson M.R.E. 285; H. E. Erookes 265; H. E. Stagg 225; S. Greenfield 213; D. I. Coomber 205. The President declared the following to have been elected Ordinary Members of Council H. E. Rrookes €3. M. N. H. Irving W. C. Johnson M.R.E. H. E. Stagg R. E. Stucltey and T. S. West. A. S. Beidas E. Hishop H. J Cluley C. A. Johnson G. W. C. Milner and F. H. Yollard having been elected members of the Council in 1963 will by the Society’s Articles of Associa- tion remain members ol the Council for 1964. J. F. Clark (Chairman of the North of England Section) ,I. K. McLellan (Chairman of the Scottish Section) E.A. Hontoir (Chairman of the Western Section) W. T. Elwell (Chairman- elect of the Midlands Section) I>. C. Garratt (Chairman of the Analytical Methods Committee) K. A. Williams (Chairman of The Analyst Editorial Committee) A. G. Jones (Chairman of Analytical Abstracts Committee) and L. Brealey (Chairman of the Programmes Committee) will be ex-oficio members of the Council for 1965. 29 ,I. H. Wamence. for the ensuing two years- 30 REPORTS OF MEETINGS [Proc. SOC. Anal. Cheqe. The retiring President Dr. Garratt thanked the Honorary Officers for their services to the Society during his term of office. Dr. Amos (immediate Past President) expressed the Society’s gratitude to Dr. Garratt who not only had carried out the duties of President for the past two years but also had continued to serve the Society as Chairman of the Analytical Methods Committee.Dr. Garratt then formally installed Mr. Smales in the Chair. After the business outlined above had been completed the meeting was opened to visitors and the retiring President delivered his Presidential Address (which will be published in a subsequent issue of Proceedings). The President MIL A. A. SMA12Es O.R.E. whose election to the Presidency of the Society is reported c~ 1 mve was a Vice-president in 1957-58 and again in 1964 and a member of Council in 1950-56 1954-56 and 1962-63. He was a committee mem- ber of the then Physical Methods Group for several years being Chairman of the Group in 1953-55. He has served on most of the Committees of the Society appointed by the Council to direct the Society’s activities.Mr. Smales is Head of the Analytical Chemistry Branch at the Atomic Energy Research Establish- ment at Harwell where he went in 1947. Before that he worked in the Analytical Department of I.C.I. (Billingham Division) from 1932 apart from a period in 1944-45 when he was attached to the Y-12 electromagnetic isotope-separation project at the Oak Ridge Laboratories in Tennessee U S A . He was a Founder Committee Member of the Nerks Bucks and Oxfordshire Sub-section (now the Thames Valley Section) of the Royal Institute of Chemistry is a member of the Rilineralogical Society’s Sub-committee on Isotope Geochemistry of the Sub-committee on Analytical Chemistry of the British National Committee for Chemistry and is active in international affairs of analytical chem- istry being a member of the Analytical Chemistry Division Committee of the International Union of Pure and Applied Chemistry and of the Geochemistry Commission of the Inorganic Chem- istry Division of I.U.P.A.C.NORTH OF ENGLAND SECTION THE fortieth Annual General Meeting of the Section was held at 2.30 p.m. on Saturday January 30th 1966 at the Old Nag’s Head Hotel Lloyd Street Manchester. The Chair was taken by the Chairman of the Section Mr. C. J. House B.Sc. A.R.C.S. F.II.1.C. The following appointments were made for the ensuing year Chairman-Mr. J. 17. Clark. Vice- Chairman-Dr. W. Cule Davies. Honorary Secretary and Treasurer-Mr. G. F. Longman Unilever Research Laboratory Port Sunlight Cheshire. Members of Committee-Dr. J. R. Edisbury Mr. R. N. Flynn (co-opted) Mr. R. Hulme Mr.A. 0. Jones Mr. C. A. Macdonald Mr. F. C. Shenton and Mr. €3. Sinar. Mr. H. Pritchard and Mr. C. E. Davis were appointed as Honorary Auditors. The Annual General Meeting was followed by an Ordinary Meeting o€ the Sectior; at which the retiring Chairman C. J. House l3.S~. A.R.C.S. F.R.I.C. gave an address on “Fat Extraction in the Analysis of Foodstuffs and Related Material.” The Chair at this meeting was taken by the new Chairman Mr. J. F. Clark M.Sc. A.R.C.S. D.I.C. F.R.I.C. F.R.S.H. SCOTTISH SECTION THE thirtieth Annual General Meeting of the Section was held at 1.45 p.m. on Friday January 22nd 1965. In the absence of the Chairman of the Section Dr. R. A. Chalmers B.Sc. F.R.I.C. the Chair was taken by the Vice-chairman and Chairman-designate Mr. J . K. McLellan. The following office bearers were elected for the forthcoming year Chairman- This vote of thanks was carried by acclamation.March l965] PAPERS ACCEPTED FOR PUBLICATTON 31 Mr. J. IT. McLellan. Honorary Secretary and Treaswer-Mr. J . W. Murfin Boots Pure Drug Co. Ltd. Airdrie Works Airdrie Eanarkshire. Mewzbers of Committee-Mr. W. A. Alexander Dr. IC. A. Chalmers Mr. W. Dunnett Mr. J . W. A. Ersltine Dr. J. A. Hunter and Mr. G. 72. Jamieson. Mr. J. S. Foster and Mr. 13. A. Sutter were re-appointed as Honorary Auditors. WESTERN SECTION THE tcnth Annual General Meeting of the Section was held at 5.30 p.m. on Friday January IZth 1965 at the College of Science and Technology Ashley Down 13risto1 7 . The Chair was taken by the. Chairman of the Section Mr. E. A. Hontoir 13.Sc. A.I.M. The following appointments were made for the forthcoming year Chairman-?r.E. A. Hontoir. Vice- Chairanma - -Dr. L. E. Coles. Homravy Secretary and ?‘reas.urer-Dr. T. 6. Morris Rrockleiglz Clevedon Avenue Sully Glamorgan. Members of Committee -Dr. I). Iktteridge Mr. W. Cassidy Dr. G. V. James Dr. F. 1%. Pollard and Mr. ,J. I). li. Thomas. Mr. S. Dixon and Mi-. C. H. Manley were re-appointed as Honorary Auditors. The Annual General Meeting was followed by an Ordinary Meeting of the Section at which the following paper was presented and discussed “Editing a Scientific Journal,” by ,I. 1;. httrill MA. F.R.I.C. MIDLANDS SECTION AN Ordinary IIeeting of the Section was held at 6.30 p.m. on Tuesday February 211~1 1965 at tlic Haworth Lecture Theatre Chemistry Department The University !<dgbaston Kirmingham 15.The Chair was talten by the Chairman of the Section Mr. W. H. Stephenson F.P.S. 1I.I3.A. F.R.I.C. 1 he following paper was presented and discussed “pH and its Significance,” by Professor Lord Wynne-Jones E.Sc. I).%. ];.Inst .F. F.R.I.C. Vice-Chairma.tz-Dr. D. M. W. Anderson. r\ MICRQCHEMICAI MIZTHODS GROUP THE forty-eighth London Discussion Meeting of the Group was held at 6.30 p.m. on Wednesday J anuary 27tl-I 3 905 at “The Feathers,” Tudor Street London E.C.4 The Chair was taken by the Chairmaiz of the Group Mr. 11. W. Wilson M.Sc. F.R.I.C. A discussion on “The Determination of Small Quantities of Water with Particular TCefcrcncc to the Meidel Cell Technique” was opened by Niss J. k. IXxon F.II.1.C. RIO1,OGICAL METHOI1S GROUP TING of the Group was held at 6.45 p.m. on Thursday February Ilth 1965 at “The The Chair was taken by the Chairman of the i\n address on “Methods of Estimating Activities of Commercial Enzymes” was given Featliers,” Tudor Street London E.C.4. Group Dr. M. W. Parkes I3.Sc. by 1:. Collier A.K.I.C. A.1C.C.T.S.

ISSN:0037-9697    

DOI:10.1039/SA9650200029

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

PAPERS ACCEPTED FOR PUBLICATTON 31 Papers Accepted for Publication in The THE following papers have been accepted for publication in The Afialyst and are expected to appclar in the near future. “The Determination of Carbon and Hydrogen in Organic Compounds Containing liIa!tethyltliymol Blue as a Reagent for the Spectrophotometric D&mnination of “The Determination of Small Amounts of Water in Some Organic Liquids,” by E. E. “The Colorimetric Determination of Ethanol in Blood with Vanadium Oxinate,” by “Radiometric Determination of Silver,” by J. van 12. Smit. “A Simplified Method for Determining Fibrous Residue in Wheat Meals and in 13rown and “The Identification and Determination of Cationic Surface-active Agents with Sodium Mercury,’’ by T. F. Holmes and A. 1,auder. Magnesium,” by J. Metcalfe. Archer and Ill. W. Jeater. P. I(. van Gent and ,I. 1.3. Merrich. Wholemeal Breads,” by H. Zentner. Tetrapheng~lboron,” by J. T. Cross.

ISSN:0037-9697    

DOI:10.1039/SA9650200031

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

32 TOXIC SIJBSTANCES I N AIR [I’Yoc. Soc. Aaal. C‘hem. Toxic Substances in Air The following are summaries of papers presented at the Ordinary Meeting of the Society held on November 4th 1964 and reported in the November 1964 issue of P~oceediags (p. 113). The Significance of Maximum Permissible Concentrations I3Y J . c. GAGE (Impevial Chemical Industvies Ltd. Indastvzal Hygiene JZescavch Labovatovies i? ldevley Pavk Ckr\lt wc) Yiz. GAGE said that the list of maximum permissible concentrations issued by the Factory Department of the Ministry of Labour was at present identical with the list of tlireshold limit values published annually by the American Conference of Governmental Industrial 1-1 ygicnists. It was stated that these figures were not to lie taken as a clear demarcation between saic arid dangerous concentrations but rather to be used as guides in the maintenance of satiskctory working conditions.In the latest list there was the suggestion that there might be a few hypersensitive individuals who might experience discomfort a6gravation of an disease or who might develop an industrial disease from concentrations at or below the thres- hold limit value. Moreover the figures might have to be modified if men were working excessive overtime or were involved in an unusual physical stress. 13efore 1963 all the American tlireshold limit values had been defined as time-wcighted average concentrations over an $-hour working day. The extent to which the transient con- centrations in an industrial atmosphere might be allowed to fluctuate around the av concentration would depend 011 several factors the site of action the nature of the toxic.and the rate of nietabolisni and excretion of the substance. It was to be expected that primary effect of a substance vvas a marked irritation or an acute toxic action a smaller excursion of its concentration above the average would be permitted than if its primary c+Fcct had been a slow curriulative action on the body. This had been taken into consideration in the 1963 list of American threshold limit values in which the concept of the ceiling value appmred for the first time although the allocation of these values did not always appear to correspi9ncl to the known toxic actions of the substances. When limits were so designated it was implied that the conccntration of tlie substance concerned should not exceed the limit even for short periods.Tlit measurement of an instantaneous concentration was something of an anal>-tical fiction since all methods required a finite sample of air and therefore yielded an avcragc result althouglr with direct instruments the degree of integration might be very small. The analyst had however a clear indication that when a ceiling value was involved he had to keep his air sample ;is small as possible and search for a method of high sensitivity. In recent years much attention had been directed towards the reliability of the methods by which maximum permissible concentrations were established. On the whole the figures made a notable contribution to the prevention of industrial disease though there was a tcndcmcy towards a progressive reduction of the figures from the experience gained through increased industrial usage and from the application of more refined toxicological and clinical mctlioils.As the evidence on which the figures wcre based was often incomplete and sometimes contra- dictory it was unnecessary for the analyst to elatncxate a method of high precision for de- termining atmospheric concentrations and an error of up to A20 per cent. was probably per- missil->le. The accuracy of the methods was more important and this applied particularly to commercial instrumental methods and indicator tubes which should not be used unless their reliability had been checked. 1 liere was a t present a tendency not to ascribe maximum permissible concentrations to those substances with a known or highly probable carcinogenic action on man.It was true that such substances should not he manufactured and used but until tlie manufacturc and use of such compounds was banned by international agreement some guidance sliould be given on how to maintain conditions that were as far as possible free from liaxard. One appToach might be tlie establishment of a limit at the lowest concentration that could be ach~evcd at an agreed level o f precision l->y the most sensitive available method; this was probably the basis of the two values for substances showing allergic-type sensitising pheno- mena tolylenecli-isocyanate and beryllium. It was probable that if challenged the analyst could measure concentrations as low as or even lower than the figure of 2 pg per cubic metre established for beryllium dust. c. March 1965] TOXIC SUBSTANCES IN AIK 3 3 Air Sampling for Industrial Hygiene T:Y S.G. LUXON MR. LUXON said that a heavy responsibility rested on the shoulders of those who carricd out the sampling of air for the purpose of deciding whether or not an industrial atmosphere was safe. It was imperative that in every instance all possible precautionary measures were applied i.e. automation enclosure and exhaust ventilation to prevent the contaminant entering the air of the workroom. The person making the test needed a knowledge of the process so that lie could select the correct places at which to take samples and could place a proper interpretation on the results so obtained. It might be necessary under difficult circumstances to take a sample with a respiratory device to determine the actual amount of contaminant inhaled.Various mcthocls for sampling and their limitations were discussed. In general large samples avoided errors caused by contamination and simplified analysis But could not be used with substances having a ceiling on the threshold limit value. It was desirable to calibrate the method with a standard atmosphere. In interpreting the results obtairied it was necessary to allow a margin for the deteriora- tion of the exhaust equipment when this was used. The possible presence of otlier contarni- nants had to be considered as they might interfere with the methods used for analysis and had (I1.M. 1;actov-y Inspectovate Ministry of Labour 19 St. James’s Squave Lovzdotz S . W . 1.) tn hn tqL6.n i n f r i c > ( \ c - f \ i i n t iii d o 4 J i n u whotlir~r f \ r nnf Q nQrtic,iilQr ~ + n o < n h m - c ~ WCIC cafrl Determination sf Toxic Substances in Air by Gas Chromatography HY S.KAMTNSKY ( I yylperirxl Chemical 1 ndustviea Idd. Ijyesti/lffS Ilivisiozi Blachlcy Mntzc hcstev 9) Mrt. KAMINSKY said that gas chromatograpl;iy with its sensitivity and selectivity was eminently suitable as a general means o f cletermining toxic substances in air eitlier alone or in admixture and was especially valuable for organic compounds most o f whicli had unti 1 then reciuircd fairly lengthy analytical methods lacking in selectivity. The Aamc ionisation detector which combined high sensitivity to organic compounds with insensitivity to air and atniosphcric moisture was preferred for most applications but otlier detectors might lie more suitablct in some instanc the elcctron-capture detector for determining tmlogcnated compounds.’The photo on detector had potential promise since it was extremely sensitive to both organic ganic compounds insensitive to air and watt.r and capablt. of bcing used for direct sarrqling of air. r . 1 lien were three main methods-- (1) Ilircct injection of the sample of air on the gas cliromatograph either from a sarupl- ing loop (if the cliromatograph could be brought into the actual atmosphere to be tested) or more usually froin a hypodermic syringe. ‘The syringe might also be used for storing the sample or this might be done in a gas- sampling bulb. The volume of the sample should be sufficiently small so tliat the injection corrcspondcd reasonably to a “plug” load otherwise separation might be impaired.?‘he method was usually suitable for lower-lmiling compounds (i.e. those having boiling-points below about 100°C) ; with highcr-bc ,mpounds there was a risk of substantial losses by adsorption on the walls of either th ling bulb or the syringe or h t h . (2) Sampling hy absorption of the atmosphere in ;L suitable solvent contained in a bubbler with subsequent injection of an aliquot of the solution on the column. The choice of solvent was important since both its main peak and any impurity p d t s had to be well separated from those of the toxic substance being determined; in certain instances the separation might be improved by converting the toxic substance in solution to a higher- boiling derivative (e.g. bromination of an unsaturated compound). Low-boiling ahsorption solvents that had been used (usually at OoC) included methanol and hexane; with these the main solvent peak was eluted before the toxic-substance peak.Water could sometimes be used as the ahsorption solvent with a subsequent extraction of the toxic substance into a small volume of carbon disulphidc ; this increased the concentration of toxic substance and simplified injection. 34 TOXIC SUBSTANCES I N AIR [PYOC. SOC. AnaZ. Chew. (3) Sampling with a small glass absorption tube containing a solid absorbent packing material with subsequent thermal desorption on to the column (F. I<. Cropper and S. Kaminsky Anal Chew. 1963 35 735). The main advantage of this method lay in its increased sensitivity since the tube acted as a concentrating device and thus usually permitted a much larger sample to be introduced on the column than in methods (1) and (2).Another advantage was the portability especially since the volume of the sample (usually between 100 and 1000 ml) was small enough for the sample to be taken with a hand-pump. The main disadvantage was that the retention volume was not as reproducible as that obtained by injection from syringe or solution. The absorption tube might contain an adsorbent e.g. silica gel or a conventional gas - liquid chromatographic packing material; the latter was usually preferred since under these condi- tions tlie toxic substance was almost always readily desorbed on heating whereas adsorption was frequently irreversible with solid adsorbents. The gas - liquid chromatographic packing matcrial favoured was 30 per cent. Silicone Elastomer 15301 - Celite mixture since this had good thermal stability and was sufficiently retentive to permit most of the toxic organic substances listed by the Ministry of 1,abour to be readily determined.The Conductirnetric Determination of Microgram Quantities of Phosphine in Air BY S. GREENI;IEI,I) 13. Y m r i y AND H. A. MOULE ( A lbvight & Wilson ( M f g ) TAul. Oldbwy Nivvuziizgham) Mn. MOIJLE suggested a conductimetric cell as a highly sensitive means of detecting and determining small amounts of phosphine in air. The method depended on the reaction between phosphine and mercuric chloride to give hydrogen chloride. The change in conductivity of a mercuric chloride solution that occurred as air containing pliosphine was passed through the solution was a measure of the amount of phosphine in the air.Among the aspects of tlie method that were discussed were the design of a suitable cell and tlie requirements for steady-flow conditions the effect of changes in temperature and compensa- tion for these changes factors governing tlie choice of electrolyte the calibration technique the app;~r;ttus for measuring the conductivity and the effects of other gases. Radioactive Fall-out Some Meteorological Aspects BY D. H. PEI'IISON ( I 1eaIth I'hysic s 6 Medical Division A tomzic Iinevgy Reseavch Estal'lishnzenf Havwell ljevks.) MR. P Z ~ ~ S O N divided the subject matter of his paper into three parts- PROGRAMME OF SAMPLING AND ANALYSIS- - He said that rain was collected from eight stations in the U.K. and from a total of 27 between 70" N and 75" S. Atmospheric dust was sampled near ground level at five U.K.stations and at Hong Kong over the eastern Atlantic at 1500 and 18,000 feet and occasionally in the lower stratosphere. Rain samples (mainly after chemical separation) were analysed for strontium-90 strontium-89 and caesium-137 and atmospheric dust (mainly a-fter automatic y-ray spectro- metry) for caesium-137 cerium-144 zirconium-95 barium-140 etc. l<P;SULTS OF FALL-OUT MEASUREMEWTS- The time for which nuclear debris remained in the troposphere was one month and longer in the stratosphere. Generally kiloton weapons injected debris into the troposphere and megaton weapons penotrated into the stratosphere. There was a pronounced seasonal variation of tropospheric fission-product concentration. Fission-product ratios indicated uni- form mixing in tlie stratosphere of debris from explosions widely separated in latitude and time.There was a pronounced variation with latitude of fission-product concentration in rain. hEODEL 01; ATMOSPHERIC TRANSPORT PROCESSES- It was possible to construct a model of the atmosphere based on fission-product observa- tions evidence from meteorological data and measurements of water vapour and ozone. March 19651 mxIc SUBSTANCES IN AIR The Behaviour and Analysis of Radio-iodine at Very Low Concentrations BY A. E. J. EGGLETON (Ilealth Physics i ? Medical Divisiouz Atomic I<~~ergy lZeseavch IZstablishmeuzt Hamell Nevizs.) 35 DR. EGGLETON stated that for various reasons radio-iodine was one of the most important isotopes that might be released in the event of an accident to a nuclear reactor.Because of the high specific activity of the iodine the mass released might be extremely small but the amount of radioactivity highly significant. Thus in the accident at Windscale in 1957 some 20,000 curies had been released but this had amounted to only 2 g of iodine and the concentration in the gases passing up the stack had been only 1 pg per cubic metre. It was of considerable interest therefore to study the physical and chemical beliaviour of iodine in air and other gases at this low concentration. Earlier experiments carried out at Warwell in the containment vessels of the DII>O and PLUTO reactors C. Chamberlain A. E. J. Eggleton LAJ. J . Megaw and J . It. Morris d)isczzss. Fwaday SOC. 4960 No. 30 p. 162 and l?. G. May and W. J. Megaw J. NmZ. Enev. Parts A[E 10638 16 427) had demonstrated the complex behaviour of elemental iodine labelled with iodine-132 when released at initial concentrations of I pg per cubic metre.TlJse of a rnulticomponeiit air-sampler had shown the presence of elemental iodine (adsorbed on fine copper gauze) particulate iodine (caught on a membrane filter) and some relatively unreactive compound form of iodine (captured on activated charcoal). The elemental iodine had rapidly disappeared from the gas phase by adsorption on surfaces leaving the other two forms as the predominant air-borne species after about 1 hour. The compound form of iodine had proved the most difficult to remove in an air-cleaning plant and therefore there was considerable interest in determining its identity. 1% technique for producing iodine compounds in the laboratory had been developed in which carrier-free sodium iodide-I31 had been oxidised in a stream of air at 490" C.The product had been mostly elemental iodine which had been removed on a knitted mesh of copper wire but sufficient radio-iodine in compound form had remained for investigation. Because of the small mass involved about g many conventional analytical techniques hat1 not been applicable. The first technique applied had becn solvent extraction which liad indicated the presence of two fractions one of which (fraction A) had been extracted readily into benzene whereas the other (fraction R) lrad been partitioned roughly equally between bcnzene and aqiieous phases. Further attempts to identify fraction 13 by oxidation retluction etc. lrad been unsuccessful.Fraction A when passed through a gas chromatograph containing a column of dinonyl phtlialate on Celite had been found to contain at least seven components but most of the activity had been found in the component first eluted from the column. A molecular-weight determination had becm performed on this component by using an adaption of the classical effusion technique. The component had been transferred after removal of permanent gases and water vapour to a 74)-ml bulh placed over a y-ray scintillation counter. "The gas had been allowed to effuse from the bulb through a O-003-inch diameter bole into ;t high vacuum. The rate of effusion was proportional to the pressure and inversely proportional to the square root of the molecular weight so that a semi-logarithmic plot of the aniount o E radioactivity remaining in the bulb versus time had yielded a straight line.From the slope of this line and from the calibration constants of the apparatus determined by calibration with krypton-% and xenon-133 the molecular weight of the iodine compound had been found to be 152. Froni a consideration of the molecular weights of known iodine com- pounds and ruling out inorganic compounds on the basis of the chemical properties of fraction A the liltely possibilities had been methyl iodide (molecular weight of methyl iodide-131 ;=; 146) and vinyl iodide (molecular weight of vinyl iodide-131 = 158). A precise comparison of the cliromatographic retention volume of methyl iodide with that of the unknown compound had shown that they were the same and this had been confirmed by measuring the molecular weight of labelled methyl iodide with the effusion apparatus and a value of 150 had been obtained.Thci other components of fraction A had been identified as higher-alkyl iodides up to the butyl isomers by measuring their rentention volnmes and this had been confirmed in some instances by molecular-weight measurements (A. E. J. Eggleton and D. H. F. Atkins Radiochim. Acta in Subsequently methyl iodide had been identified in the fraction comprised of the iodine compound formed when iodine was released in the DIDO containment vessel when irradiated tl1c press). 3 6 PUBLICATIONS RECEIVED /Proc. Soc. Anal. Chew. uranium metal was oxidised in air and when irradiated uranium dioxide was heated in carbon dioxide - carbon monoxide mixtures (R. D. Collins and A. E. J. Eggleton Yroc. 3rd Ifitern. C'maf. Peaccfd Uses Atomic Energy 1'/186 United Nations Geneva in the press). A sub- stantial part of the iodine released in this last situation which resembled possible accident conditions in a gas-cooled reactor had been found as methyl iodide.

ISSN:0037-9697    

DOI:10.1039/SA9650200032

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

Publications Received ‘17ie publications listed 1)clow have been received by thc I1:ditor of 7’he Analyst in which journal I3ook I<cviews will continue to appear. U N I ) ISRZISS. 13y Prof. Ilr. JOZSISF MILKA. Pp. 843. 12udapcst Akadhiai KiadO. 1%4. I’ricc $ 1 2.00. xiv + 1280. Washington I ).C. 0.S. Government I’rinting Office. 1964. I’rice $4.25. J . W. I<Ni(;FiT I<.%. P l i . l ) . 1;.1<.I.C. 1;. 1C.A C.I. 1965. Pricc 45s. I’rinccton (New Jcwc%y) ‘I’oronto New York and I,ontlon I ) . V a n Nostrand Company I nc. 1966. f’ricc 93s. I’m-is antl Hutltlcrsfield Editions Scientifiques Hermann. 1964. Price 59s. NUCLICAR ‘I’EC‘HNIQU~.:S I N ANALYTICAL CHISMISTI~Y. f3y ALIWI:I) J . Mosrss. Pp. viii 1 142. Oxford I,ontlon ISclinburgti New \'ark Paris rtnd Icrankfurt I’crgamon I ’rvss.1964. I’riccb 45s. 1 rchizi&mc Si-ric. Cie. 1964. I’ricc 66F. New York antl Frankfurt I’ergamon Press. hl ISTALLU 1<G1 SCHIS ANALYSEN CH 13M lSClI I3 I :N*t.El<SLJC€rU N<; VON TECHN ISCH WICHTT(XCN M ETA LLlCN ANALYSIS O F I k S E N T I A L NUCLEAR ICiSACTOI< MATKRIALS. $:ditd by CLlClflI~NT J . 1<OI)I)I*;N. I’p. ‘!’HI< C1i I<MlSTI<Y 0 1 ‘ W H E A T STARCH AN 1) (;LUTISN AN1) ‘rFi1CTR COXVIC1<SlON I:IZOI)UCTS. 13y T’p. xii 1- 156. I,ontlon 1,conard Hill. (;OLlf ~~l~;COVISl<Y ~’i<O€~iSl<TlES ANI) APIWCATIONS. ).:ditCd by l<i)MIJNl) M. bVlSf3. j’p. X 4 :$67. ’~‘ISTI<ACYCLIC ‘~’KITJSIZPiSNKS. J3y GUY OUIUSSON ~’115KK13 CI<AI<I<I? and o S C A l < J < . 1COI)lG. r’p. 237. MISICS ATJ I’OINT 1115 CH I M 115 ANALYTIQUIS oIZ(;AN lQKJt< ~’i-IAI<VACISUI‘IQU IS IST I3I<OMA’TOLOGI QLTIC.r. IGlitcd by J .-A. (;AIJTIKI< and 1’. MALANGISA~~. I’p. 236. I’nris M\il;Lsson ct Ac*11)-13 \sir TGjtiIidii%i<i.A. Hy lidwartl J . King. 1’1). xii 341. Oxford I,ontlon I<clinl~urgli The I iftev- Iitlitctl b y 15. ICutner 1’. (;oldfinger and J . 1’. Hii-tti. Proceedings of the International Symposiwn on Condcnsulion and Jiiiaporation of Solids llu-yton Ohio September 12th- 14th 1 !%2. AN IN’T1ZOI)IIC*l‘iON ‘ro ~ I C I < ~ I < I O I A ) ( ; Y . I3y W. 13. HUGO 13.Pharni. ph.l). F.I’.s. %“p. x 1 146. AN 1 N~IIZOI)UCTION 1-0 PAI~AS~~OLOGV. f3y J O H N M. WATSON l>.Sc. A.I<.C.Sc. I’p. viii 184. I’rice i 20s. I’olz4me 4 of Tofiic 1 6 “IGpdiOrium Propertaes of Ilfectrolyte Solutions,” of nutional Iincyclojwdiu cq Physical Chevnistvv nnd Chemical Physics. ” CONI)ICNSATION ANJ) 1‘:vAiwi:X-rioN 01’ SOI,II)S. I’p. xiv. -1 705. N e w York and 1,ontlon Gordon and I3rcw3i. 1964. Price $38. I ,r)ntlon William Heinemaim Medical t3ooks 1,imitecl. 1 965. Price 20s. I ,ondon William Heincmmn Medical 13ooks I .iniitetl. 1965. 20s. Changes in the Register of Members NEW MEMIZEKS OIWINARY MISMI~EI(S Ixonard ICalpli Ainsworth I1.Sc. (Sheff.) A.II.1.C. ; Ivan Austwiclc JZ.Sc. (Lond.) ; Keniietli Ivor Ikynon Ph.D. l3.S~. (Wales) ; Arthur William Rrown R.Sc. (Liv.) A.II.1.C. ; Michael Collard A.IC.1.C. ; David Andrew Forrest FI.Sc. (Edin.) ; Terence Hanna A.TI.1.C. ; William Elwyn .Jones M.Sc. (Wales) F.1I.I.C. ; ‘I‘hornas Manson A.H.-W.C. F.II.1.C. ; Malcolm Riley 13.S~. (Sheff .) ; I3arry Theohald Saunderson ; 13rian Edward Talbot ; Peter Charles Wildy 13.S~. (Lond.) ; Charles Ronald Worthing D.Phil. I<.Sc. M.A. (Oson.).

ISSN:0037-9697    

DOI:10.1039/SA9650200036

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

March J 9651 SAC CONFERENCE 1 !I65 3 ’7 SAG Conference 1965 This preliminary list of papers accepted for the SAC Conference 1965 is arranged alphabetically by first authors and will be supplemented in subsequent issues of 1’YoceediTzgs. ‘The Use of Thin-layer and Semi-preparative Gas - 1,iquid Chromatography in the Iletection Determination and Identification of Organo-phosphorus Pesticide Residues,” by D. C. Abbott N. T. Crosby and J . Thomson. “An Infrared Method for the Determination of Small Amounts of Acetaldehyde in Aqueous Solution,” by D. M. W. Anderson and J . 17. Stoddart. “Voltammetric Studies with Different Electrodc Systems. Part I Molybdenum as Rclference Electrode in Polarography,” by V. T. Athavale S. V. 13urangey and It. G. Dhanesliwar. “A New Reagent for the Determination of Microgram Amounts of Osmium,” by 1,.S. I3ark and 11. I-trandoii. “Studies in the Relationship between Molecular Structure and Cliromatographic Ikliaviour. Part IV The Ikhaviour of Some Nitrophenols Chrornatographed by l’artition Chromato- graphy,” by 1,. S. 1Sark and I<. J. T. Graham. “The Direct Conductimetric Titration o f Acidic and Hasic Compounds Resolved by Thin-laycr Chromatography,” hy W. I3onrdman and 13. Warren. “A Standard Biological Material for Elementary Analysis,” by H. J. M. I-towen. “The Detei-minatiou of T r x c Amounts of Silver with I>iphenylthiocarba;r,one in High Purity Cobalt Lead Nickel Zinc and other Metallurgical Products,” by K. Carson and E. (i. Walliczek. “Organic-phase Spectrophotometric Determination of IronLi1 with Thiocvanate aftcr Extraction with I>i-(2-ethylhexyl)orthophosphoric Acid,” by E.Cerrai and (i. Ghcrsini. “A Study of Silicon Determination in Organo-silicon Coinpouncls by X-ray B‘luorescencc with Vacuum Spectrograph,” by 1’. Id. Chan. “The Detcrmination o f Indium by Solvent Extraction Followed by ItStliylenedi~~minetc.tr~~- acetate Titration,” by ,I. A. Clements and T. Davies. “Encapsulation ;IS a. ‘Technique for the Iletermination of Hydrogen in Volatile Metals,” by I;. R. ( h e N. .Jenkins ;~nd IJ. €3. Parker. “Some Fundamental Aspects in the Practice of ’Thin-Iaycr Electrophoresis,” by ’147 - J. Criddle G. ,I. Moody and J. I). li. Thomas. “The Determination ol Micrograni Amounts of Fluoride by a Pyrohydrolytic 1,anthanuni - Alizarin Complexan Procedure Dcsigned for lt’lutonium-containing hlaterials,” by? A.(;. Davies a n d .J. I<. Forcman. “Aniinoanthracluinoiae Indicator Dyes and their Application,” by 1. Krausz and A. Endroi- Hav;~s. “’The Determination of ‘Tellurium in Gallium Arsenide and Germanium by Neutron Activation Analysis,” by K. W. Lloyd. ment of Systematic Errors by Ilioutine Analytical Work,” by D. I,. Lydersen. “Studies on Nickel“ Dioximes of Analytical Importance,” by Bi. J. Magee and 1,. Gorc?lon. “A Cri t i c d Evaluation of Differential Keact ion-rat e &I e t hods Employed for the Simult ancc )us Part I First-order and Pesudo First-ordcr Analysis of Closely Related Mixtures. Methods,” by H. 12. Mark K. A. Greinke and L. J. Papa. “Fundamental Studies in Automatic Digestion,” by ,J. 1;. Marten and (;. Catr-lnzaro. “The Examination and Determination of Cephaloridine,” by J .I,. Martin and W. H. C. Shaw. “A Rapid Method of Determining Soluble Silicates,” by 13. M. Milwidsky and S. Holtzman. “A Kinetic and Titrirnetric Study of the Determination of Iron with Potassium It-Sromatc.,” by J. M. Ottaway and E. I-Sisliop. 3a NOTICES [Proc. SOC. Anal. Chew. “Organic Trace Analysis by Measurement of Photoluminescence,” by C. A. Parker. “‘A Method for the Estimation of Commonly Used Non-ionic Detergents in Sewage EfAuents,” “’The Application of Controlled-potential Coulometry to the Determination of Plutonium,’D “’l’he Determination of Certain Trace Metals in Very Pure Waters by Automatic Analysis,” “Some Applications of Yolarogrzphy in Physiological Analysis,” by K. C. liooney. ‘‘ ICecent Advances in the Analysis of Polyvinyl Chloride Compositions,” by L. H. Ruddle “Analysis of Phosphatides by means of Potentiometric Titration in Non-aqueous Medium,” “‘hiialysis of Plastics Materials X-Ray Fluorescence Examination of Volatile Liquids with “Frictors Affecting thc Formation and Solvent Extraction of the Complex of Nickel with by S. J. Patterson E. C. Hunt and K. B. E. Tucker. by G. Phillips and G. W. C. Mjlner. by F. A. Pohl. S. D. Swift J. Udris and P. E. Arnold. by I?. Smits and J. Kuiper. the Philips PW1540 Spectrorneter,” by D. C. M. Squirrcll. Furil-a-Dioxime,” by A. I>. Wilson.

ISSN:0037-9697    

DOI:10.1039/SA9650200037

出版商:RSC    

年代:1965

数据来源: RSC

摘要:

NOTICES [Proc. SOC. Anal. Chem. Notices PHAKMACEUTICAL SOCIETY OF GTIEAT KIiITtZlN THE DESIGN 01; SPECIFICATIONS IWR T_)KTJGS* YT advances in analytical techniques have revealed the presence in some drugs of to unsuspected impurities with potent undesirable pharmacological effects. Many such drugs give a satisfactory assay result when examined by the usual quantitative methods. The Science Committee (Pharmaceutical Analysis) of the Department of Pharmaceutical Sciences lias discussed the design of specifications as set out in the current Itritish Pharma- copoeia and the British Pharmaceutical Codex and has formulated ideas for the iuture. Tlw Committee’s work has shown the need to apply a more critical approach to specifications for all drugs. This will involve a great deal of investigational work and it slmuld be started without delay.CIilTlClSMS 01; EXISTING SPECIFICATIONS- The present conventional form of specification which was acceptable at a time when the wc;tltli of modern analytical techniques was unavailable is inadequate for tlie potent and complex drugs now being produced. This i s particularly noticeable wlrcre in a group of drugs of a very similar chemical structure small differences in the composition or even the spatial arrangements of the molecule may alter the potency considerably. Compounds having such small differences in composition can often be produced simultaneously during syntliesis with the possible result that impurities generally of a lower potency but sometimes more toxic remain in the commercially purified drug. These im- purities are not necessarily detected or determined by tests included in the specifications with the result that the standards set €or the drug can he satisfied with such impurities present.The determination of the content of pure substances should be replaced by tests to limit the content of impurities. This change of emphasis is desirable even if a study of more fundamental physical properties enabled a better assessment of the purity of a commercial sample o f a drug to be made or if methods could be devised to give more exact determinations o f the percentage purity particularly when pure reference substances are available for comparative assays. Moreover tests for specific impurities can be applied to formulated In many instances it is unrealistic. * This statement is based on a document produced by the Science Committee (L’harmaceutical Analysis\ of the Department of Pharmaceutical Sciences of the I’harmaceutical Society o f Great Britain and which has been sent for comment t o various organisations.It is reproduced lrom The Phavwzaceutical Joumtal January 2nd 1965 p. 7. March 19651 NOTICES 39 products and thus give a better assessment of the quality of the drug used. Sensitive moclcrn techniques make this practicable ; formerly it was rarely possible. In future analytical assessment of the stability of the active ingredients of formulated products during storage must also be considered; limits for the content of decomposition products after a certain storage period should be included in monographs. For pharma- ceutical purposes formulated products often contain other substances in much larger quanti- t k s than the active ingredients and adequate standards for the purity of such substances must be specified especially as many of these materials are not well-defined substances.TOXICITY TESTS- Side-effects which are presumed to be due to the drug itself may subsequently be found to be caused by impurities; as clinical trials and toxicity investigations are normally carried out on material prepared by small-scale processes it is important that the impurity pattern of the material used in those trials should be compared with that of material prepared by large-scale manufacture. Variation both in the amount and the identity of the impurities present in the final product may arise from this change-over from pilot-scale to large-scale processes and also from the use of an alternative method of manufacture and from variation in the quality of the raw materials.During development of a drug toxicity tests should be done concurrently on a sample of the chemical obtained in the purest possible form and on a sample of the chemical taken at a certain stage of its preparation; this stage should be where impurities which i t is intended to eliminate during the final purification are still present. Attention may also have to be given to products not refined by crystallisation techniques such as those purified by washing under controlled conditions or by the use of distillation or sublimation met hods. For any subsequent control purposes biological tests would seldom be required since having established which of the impurities have to be controlled these can be determined satisfactorily by chemical or physical methods.A limit for non-toxic impurities such as non-active isomers or inactive hydrolysis products is also necessary since these will diminish the potency of the material. Nevertheless the possible necessity of permitting a certain amount of impurity-even toxic impurity-in the interest of economy of manufacture should be recognised provided that any toxicity per- mitted is clinically acceptable. CONCLUSIONS- From the foregoing it follows that in the future drug standards must include tests for all impurities in a drug which may be introduced during its manufacture. Clearly each drug standard must include specific quantitative tests for possible impurities with appropriate limits according to the toxicity of the impurity and the intended use of the drug.There should he a general test such as phase-solubility measurement thin-layer chromatography gas-liquid chromatography refractometry etc. to limit total organic impurities. There should also be a screening test for example by emission spectrography to detect any traces of toxic metal remaining in a purified drug as a result of the use of catalysts that a manu- facturer might be reluctant to disclose and limits should be laid down for any such contami- nation. In order to formulate suitable specifications the responsible committees must be pro- vided with all relevant information. The disclosure of adequate details of the chemistry of a process and the practical details of each synthetic step of the raw materials and solvents used and some indication of probable impurities will be essential.Although this ~vould be b:st achieved by the close co-operation between industry and standardising bodies which has for the most part existed in the past it may be necessary in fairness to all concerned to make such disclosure a legal requirement. Once a drug has been standardised every new manufacturer would also have to comply with the full requirements of disclosure considered necessary when the drug was first approved. 40 NOTICES jI-’yoc. Soc. ATaal. Chem. SPECIAL TECHNIQUES GICOUP THE Special Techniques Group is planning meetings on the following topics for the 1965-66 session- Gas Analysis. Automatic Analysis. Special Techniques in the Power Generating Industry. The Croup Committee will be pleased to consider applications to present papers at these meetings from anyone who can describe the use of new specialist techniques in the above fields.Offers of papers should be sent as soon as possible to the Honorary Secretary of the (iroup I k . T. L. Parkinson British Baking Industries’ Research Association Chorleywood Rickmansworth Hert s. BRITISH STANDARTX INSTITUTION DRAFT SPECII~ICATIONS A FEW copies of the following draft specifications issued for comment only are available to members of the Society and can be obtained from the Secretary The Society for Analytical Chemistry 14 Relgrave Square London S.W.1 Draft Standard prepared by Technical Committee DAC/25-Antibiotics in Dairy D 65/349-Draft 13.S. Method for The Estimation of Nisin in Processed Cheese. Draft Standard prepared by Technical Committee CIC/12-Pentachlorophenol.I> 6511 207-Draft B.S. Specification for Pentachlorophenyl Laurate. Draft Standard prepared by Sub-committee M/67/2-0ilseeds and Vegetable Oils Products a (International). DS5jl273-Draft R.S. Methods for sampling Oilseeds. D65/ 1274-T>raft K.S. Specification €or Rrominated Vegetable Oils €or ‘CJse in Food- Draft Standard prepared by Sub-committee M/S3/21--Emulsifiers etc. in Food. stuffs. IMPACT OF SCIENCE ON SOCIETY VOLUME 14 No. 2 1964 THIS issue contains articles on the National Academy of Sciences of the U.S.A. the dis- covery of artificial radioactivity and the social consequences thereof biochemistry and the production of proteins from petroleum ferment a t’ ion. Iw$act of Science 012 Society is published quarterly at 1%.$2.50 or 9 F per volume (4s. $0.75 or 3 F per single copy) by Unesco and may be purchased in the U.K. through H.M. Stationery Office P.O. 13ox 569 London S.E.1 or through the Government Hookshops in U.S.A. from Unesco Publications Center (NAIP) 317 East 34th St. New York N.Y. 10016 U.S.A. in France from Libraire de l’Unesco place de Fontenoy Paris-7” or elsewhere through appropriate National bookshop. Members of the Society may obtain a free specimen copy on request to I?. Esway Promotion Section Unesco Publications place de Fontenoy Paris-7e. I)UBLISHBD I3Y UNITED NATIONS EDUCATIONAL SCIENTIFIC AND CULTURAL OIIGANISATTON SYMPOSIUM ON APPLIED MICROSCOPY UNIVERSITY OF SHEFFIELD JULY ~ T H - ~ T H 1965 A SYMPOSIUM 011 Applied Microscopy under the title Micro ’65 will be held at the University o f Sheffield from July 6th to Rth 1965.It will emphasise the industrial and applied aspects of microscopy; in particular sessions will be arranged in the fields of metallurgical microscopy and small-particle studies including but not limited to air pollution clean-room atmospheres and industrial hygiene. Specialised papers will be presented in other areas of interest to microscopists. Intending delegates should send completed forms of application before April I Zth 1965 to Professor 13. Barer Department of Human Biology and Anatomy The University Western Bank Sheffield 10 from wl-rom further information may be obtained. THE SOCIETY FOR ANhLYTIC.4L CHEMISTRY GORDOS RESEAARCH CONFEREXCES 196.5 THIS year’s Gordon Research Conference on Analytical Chemistry will be held a t Ken- Hamp- ton School New Hampton X e x Hampshire U.S.-\.from August 9th to 13th 1965. &Applications must be received two months before the date of the Conference and must he submitted in duplicate on the standard apfilicatioiz .form obtainable with further informa- tion from the Director U‘. George Parks Department of Chemistry UniT-ersity of Rhode Island Kingston R.I. US..\. Lectures scheduled include “Applications of NMR to Polymer Structure Determination,” by IVilliam M. Ritchey ; “Cation Sensitive Electrodes Theory and Practice,” by Garry A. l<echnitz ; “Applications of Differential Thermal Analysis to Polymers,” by Bernard IVunder- lich ; “General Applications of Differential Scanning Calorimetry,” by Xllan P. Gray; “Applica- tions of Differential Thermal Analysis to Non-polymeric Systems,” by Paul D. Garn ; “Nodern- isation of Nicroanalytical Methods,” by Hans Irlalissa; ‘ T s e of Group Frequency Shifts in Interpreting Infrared Spectra,” by Ji7illiam J Potts; “Applications of Infrared Spectroscopy to Ria-medical Analytical Problems,” by Iluncan Erley ; “Advances in Spark Source Mass Spectroscopy,” by Arthur J. Ahearn (Open Session) ; “Analytical Problems in Drug Meta- bolism Studies,” by Anthony J . Glazko. ~. ~ ~ - ~- ~

ISSN:0037-9697    

DOI:10.1039/SA9650200038

出版商:RSC    

年代:1965

数据来源: RSC