摘要:
IntroductionSince the discovery of natural enediynes and their biological ability to act as antitumor antibiotics1through the formation of a cytotoxic benzenoid biradicalviaa Bergman cyclisation,2strong efforts have focused on the construction of simple enediyne compounds mimicking the natural specimen.1As 9 or 10membered ring enediynes3are extremely unstable, we are interested in the elaboration of simple acyclic enediynes.4Here, we describe the preparation and interesting solid state structure of the hitherto unknown enediyne3. Whereas linear or tetrahedral tectons have been extensively studied due to their role in the formation of 2D or 3D nets,5Vshaped tectons have received much less attention. The latter building blocks have been shownto form screwtype chains, mostly, however, in presence of other Vshaped counterparts.6To the best of our knowledge, enediyne3is the first example of a Vshaped tecton to form double screws in the solid state with itself.
ISSN:1466-8033
DOI:10.1039/b103307g
出版商:RSC
年代:2001
数据来源: RSC