摘要:

Phenothiazine caused a haemolytic anaemia in three dogs used in a total of eight experiments. In one animal a diet deficient in vitamin B greatly intensified the anaemia and jaundice. Addition of vitamin B complex to normal diets did not prevent the anaemia, but it did suppress Heinz body formation and stimulate reticulocytosis. It is indicated that the B complex is necessary for erythropoiesis, but that it may have no direct effect upon the anaemia.One animal died after four courses of the drug totalling 340 gm.; its liver revealed a portal cirrhosis.

ISSN:1923-4287    

DOI:10.1139/cjr44e-001

出版商:NRC Research Press    

年代:1944

数据来源: NRC

摘要:

A large series of dogs, subjected to severe muscle trauma, has been studied. Eighty-four per cent died or would have died of shock within 24 hr. had they not been treated with a blood substitute. Of these about half developed severe shock in less than five hours. A few, 3.7% of the series, died between 24 and 80 hr., and 12.3% were considered indefinite survivors either being well when killed at 24 hr. or appearing well at the end of three days after trauma.Repeated observations made on the blood pressure and heart rate made it possible to predict death some time in advance in a great majority of cases. Haemoconcentration, as evidenced by an increase in the volume of packed red blood cells, occurred in the majority of the animals. This is ascribed partly to the fact that the fluid loss into the damaged tissues was principally plasma rather than whole blood, and partly to the fact that the animals were not deeply anaesthetized for a long time and consequently reflex splenic contraction added cells to the circulation. The blood sugar in dogs dying within three hours of trauma was normal or elevated. In dogs dying later it was often low. In those in which life was prolonged a few hours by a blood substitute the terminal value was very low. In many dogs in which life was prolonged beyond 24 hr. the blood sugar values slightly before death were within normal limits.The significance of these findings is discussed.

ISSN:1923-4287    

DOI:10.1139/cjr44e-002

出版商:NRC Research Press    

年代:1944

数据来源: NRC

摘要:

In the normal dog continuous infusion of dilute posterior pituitary extract produces a maximal inhibition of the heart, i.e. slowing to about one-half of the resting rate, with usually a rise in blood pressure of 10 to 30 mm. of mercury.After bilateral thoracic sympathectomy, posterior pituitary extract also produces maximal inhibition. This inhibition, like that produced in the normal dog, is abolished by atropine.After bilateral vagotomy posterior pituitary extract produces a moderate but not maximal inhibition. This inhibition is not abolished by atropine.After bilateral thoracic sympathectomy and unilateral vagotomy, posterior pituitary extract produces a maximal effect.After total denervation of the heart, posterior pituitary extract produces no inhibition of the heart and the rate is unchanged.Characteristic changes are produced by posterior pituitarv extract in the electrocardiogram of normal dogs. After total denervation no change takes place.It is concluded that the slowing of the dog's heart that is produced by continuous intravenous infusion of posterior pituitary extract is entirely due to its action through the inhibitory fibres of the vagus and sympathetic nerves.

ISSN:1923-4287    

DOI:10.1139/cjr44e-003

出版商:NRC Research Press    

年代:1944

数据来源: NRC