摘要:

Nine α-amino acids, namely,dl-alanine,dl-α-aminobutyric acid,dl-α-ammoenanthic acid,dl-α-amino-γ-phenoxybutyric acid,dl-C-phenylglycine,dl-proline,dl-ornithine,dl-lysine and 2-aminoindane-2-carboxylic acid have been prepared from α-substituted cyanoacetic esters. Pyrrolidine or piperidine was isolated when it was attempted to prepare ornithine or lysine by hydrolysis of diurethanes with hydrochloric acid. When a mixture of formic and hydrochloric acids and water was used as hydrolyzing agent, ornithine or lysine was obtained in low yield in addition to traces of pyrrolidine or piperidine. The following compounds, as far as the authors are aware, have been prepared for the first time: α-cyanopropionhydrazide, benzal α-cyanopropionhydrazide, α-cyanopropionic azide, α-carbethoxyaminopropiononitrile, α-cyanobutyrhydrazide, benzal α-cyanobutyrhydrazide, α-cyanobutyric azide, α-carbethoxyaminobutyronitrile, ethyl α-cyanoenanthate, α-cyanoenanthic hydrazide, benzal α-cyanoenanthic hydrazide, α-cyanoenanthic azide, α-carbethoxyaminoenanthonitrile, 5-(n-amyl)-hydantoin, ethyl α-cyano-γ-phenoxybutyrate, ethylbis-β-phenoxyethylmalonate mononitrile, α-cyano-γ-phenoxybutyrhydrazide, benzal α-cyano-γ-phenoxybutyrhydrazide, α-cyano-γ-phenoxybutyric azide, α-carbethoxyamino-γ-phenoxybutyronitrile, 5-(β-phenoxyethyl)-hydantoin, α-cyano-α-phenylacethydrazide, benzal α-cyano-α-phenylacethydrazide, α-cyano-α-phenylacetic azide, ethyl δ-bromo-α-cyanovalerate, δ-bromo-α-cyanovalerhydrazide, benzal δ-bromo-α-cyanovalerhydrazide, δ-bromo-α-cyanovaleric azide, δ-bromo-α-carbethoxyaminovaleronitrile, dibenzal α-cyanoadipic dihydrazide, α-cyanoadipic diazide, α,δ-dicarbethoxyaminoadiponitrile, dibenzal α-cyanopimelic dihydrazide, α-cyanopimelic diazide, α, ϵ-dicarbethoxyaminocapronitrile, 2-cyano-2-carbethoxyindane, 2-cyano-2-carboxylindane hydrazide, benzal 2-cyano-2-carboxylindane hydrazide, 2-cyano-2-carboxylindane azide, 2-cyano-2-carbethoxyaminoindane, 2-aminoindane-2-carboxylic acid, 2-aminoindane-2-carboxylic acid hydrochloride.

ISSN:1923-4287    

DOI:10.1139/cjr48b-051

出版商:NRC Research Press    

年代:1948

数据来源: NRC

摘要:

The compounds 1-(methoxy)-1-(4-chlorophenyl)-2,2,2-trichloroethane, 1-(ethoxy)-1-(4-chlorophenyl)-2,2,2-trichloroethane, 1-(trichloroacetoxy)-1-(4-chlorophenyl)-2,2,2-trichloroethane, and 1-(4-chlorophenyl)-2,2,2-trichloroethyl methyl succinate have been prepared for the first time as outlined below. The toxicity of these compounds and several others againstDrosophila melanogaster(fruit fly) as compared to DDT is also reported. None of the compounds submitted was found to be superior to DDT as a contact insecticide.

ISSN:1923-4287    

DOI:10.1139/cjr48b-052

出版商:NRC Research Press    

年代:1948

数据来源: NRC

摘要:

The compounds 1,1,1,2-tetrachloro-2,2-bis(4-chlorophenyl)ethane and 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) are reported to rearrange to 4,4′-dichlorobenzil by the catalytic action of sulphuric acid. Two proposed mechanisms for this conversion are discussed. Attempts to rearrange other substituted alpha-diphenyltrichloroethanes to the corresponding benzils were unsuccessful.

ISSN:1923-4287    

DOI:10.1139/cjr48b-053

出版商:NRC Research Press    

年代:1948

数据来源: NRC

摘要:

In the homogeneous oxidation of mercaptans by potassium persulphate in concentrated acetic acid, the rate of disappearance of potassium persulphate during an experiment is first order with respect to the measured persulphate concentration. The rate constant is independent of the kind of mercaptan used, and is independent of mercaptan concentration over a wide range of mercaptan concentrations. The rate constant falls off, however, at low mercaptan concentrations, this falling-off being less pronounced if the rate is reduced by the addition of salts. The mercaptan concentration at which the rate constant, calculated from persulphate disappearance, becomes independent of mercaptan concentration increases as the temperature is increased. A salt effect prevails, the rate constant being decreased with increased potassium ion concentration. The equivalent conductance of solutions of potassium persulphate in the solvent used shows a behavior on dilution which indicates that potassium persulphate is incompletely ionized in the solvent. A mechanism is proposed for the reaction, in which it is assumed that dissociation of persulphate ions into sulphate free radicals is rate-controlling, with an activation energy of the order 26,000 cal. per mole.

ISSN:1923-4287    

DOI:10.1139/cjr48b-054

出版商:NRC Research Press    

年代:1948

数据来源: NRC

摘要:

Nickel carbonyl is adsorbed by respirator charcoals without decomposition in the absence of oxygen. The amount adsorbed is reduced if the charcoal has previously adsorbed nickel carbonyl, carbon tetrachloride, phosgene, or arsine and has not been degassed thereafter. The adsorbed nickel carbonyl is oxidized rapidly by oxygen, liberating carbon dioxide, carbon monoxide, and leaving an amorphous deposit on the charcoal. This deposit is slightly more than half nickel, and does not yield an X-ray diffraction pattern. Adsorbed nickel carbonyl is decomposed thermally to give metallic nickel and carbon monoxide. The nickel is deposited in sufficient amounts to give an X-ray diffraction pattern.

ISSN:1923-4287    

DOI:10.1139/cjr48b-055

出版商:NRC Research Press    

年代:1948

数据来源: NRC